JPS6442472A - Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient - Google Patents

Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient

Info

Publication number
JPS6442472A
JPS6442472A JP62200510A JP20051087A JPS6442472A JP S6442472 A JPS6442472 A JP S6442472A JP 62200510 A JP62200510 A JP 62200510A JP 20051087 A JP20051087 A JP 20051087A JP S6442472 A JPS6442472 A JP S6442472A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
derivative
brain function
improving agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62200510A
Other languages
English (en)
Inventor
Ryuichi Iemura
Manabu Hori
Hiroshi Otaka
Takayuki Sukamoto
Hideaki Hara
Keizo Ito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP62200510A priority Critical patent/JPS6442472A/ja
Priority to ES87118691T priority patent/ES2044908T3/es
Priority to AT87118691T priority patent/ATE69049T1/de
Priority to EP87118691A priority patent/EP0302967B1/en
Priority to DE8787118691T priority patent/DE3774273D1/de
Publication of JPS6442472A publication Critical patent/JPS6442472A/ja
Priority to GR91401837T priority patent/GR3003232T3/el
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP62200510A 1987-08-10 1987-08-10 Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient Pending JPS6442472A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP62200510A JPS6442472A (en) 1987-08-10 1987-08-10 Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient
ES87118691T ES2044908T3 (es) 1987-08-10 1987-12-16 Procedimiento para la produccion de derivados de quinazolina.
AT87118691T ATE69049T1 (de) 1987-08-10 1987-12-16 Chinazolin-derivat, verfahren zu dessen herstellung und mittel zur behandlung von cerebraler disfunktion als aktiver inhaltsstoff.
EP87118691A EP0302967B1 (en) 1987-08-10 1987-12-16 Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient
DE8787118691T DE3774273D1 (de) 1987-08-10 1987-12-16 Chinazolin-derivat, verfahren zu dessen herstellung und mittel zur behandlung von cerebraler disfunktion als aktiver inhaltsstoff.
GR91401837T GR3003232T3 (en) 1987-08-10 1991-11-28 Quinazoline derivative, processes for its production, and cerebral dysfunction remedying agent comprising it as active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62200510A JPS6442472A (en) 1987-08-10 1987-08-10 Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient

Publications (1)

Publication Number Publication Date
JPS6442472A true JPS6442472A (en) 1989-02-14

Family

ID=16425510

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62200510A Pending JPS6442472A (en) 1987-08-10 1987-08-10 Quinazoline derivative, production thereof and brain function disorder improving agent containing said derivative as active ingredient

Country Status (6)

Country Link
EP (1) EP0302967B1 (ja)
JP (1) JPS6442472A (ja)
AT (1) ATE69049T1 (ja)
DE (1) DE3774273D1 (ja)
ES (1) ES2044908T3 (ja)
GR (1) GR3003232T3 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031171A1 (ja) 2002-10-01 2004-04-15 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041443A (en) * 1989-02-21 1991-08-20 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
US5185338A (en) * 1989-02-21 1993-02-09 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
HU214331B (hu) * 1992-06-17 1998-03-02 Gyógyszerkutató Intézet Kft. Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
US7019012B2 (en) 2000-12-20 2006-03-28 Boehringer Ingelheim International Pharma Gmbh & Co. Kg Quinazoline derivatives and pharmaceutical compositions containing them
DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
CA2833706C (en) 2005-11-11 2014-10-21 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
CA2663599A1 (en) 2006-09-18 2008-03-27 Boehringer Ingelheim International Gmbh Method for treating cancer harboring egfr mutations
SI2451445T1 (sl) 2009-07-06 2019-07-31 Boehringer Ingelheim International Gmbh Postopek za sušenje BIBW2992, njegovih soli in trdnih farmacevtskih formulacij, ki obsegajo to aktivno sestavino
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
DE102015012049A1 (de) * 2015-09-15 2017-03-16 Merck Patent Gmbh Verbindungen als ASIC-Inhibitoren und deren Verwendungen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1062357A (en) * 1965-03-23 1967-03-22 Pfizer & Co C Quinazolone derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031171A1 (ja) 2002-10-01 2004-04-15 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途

Also Published As

Publication number Publication date
EP0302967B1 (en) 1991-10-30
ES2044908T3 (es) 1994-01-16
DE3774273D1 (de) 1991-12-05
ATE69049T1 (de) 1991-11-15
EP0302967A2 (en) 1989-02-15
EP0302967A3 (en) 1989-05-03
GR3003232T3 (en) 1993-02-17

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