JPS644454B2 - - Google Patents
Info
- Publication number
- JPS644454B2 JPS644454B2 JP57166226A JP16622682A JPS644454B2 JP S644454 B2 JPS644454 B2 JP S644454B2 JP 57166226 A JP57166226 A JP 57166226A JP 16622682 A JP16622682 A JP 16622682A JP S644454 B2 JPS644454 B2 JP S644454B2
- Authority
- JP
- Japan
- Prior art keywords
- blood collection
- collection tube
- stopper
- tube according
- gas barrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008280 blood Substances 0.000 claims description 51
- 210000004369 blood Anatomy 0.000 claims description 51
- 230000004888 barrier function Effects 0.000 claims description 21
- 229920001971 elastomer Polymers 0.000 claims description 16
- 230000035699 permeability Effects 0.000 claims description 12
- 239000000806 elastomer Substances 0.000 claims description 7
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 7
- 229920000219 Ethylene vinyl alcohol Polymers 0.000 claims description 6
- 229920001169 thermoplastic Polymers 0.000 claims description 5
- 229920000298 Cellophane Polymers 0.000 claims description 3
- 239000004677 Nylon Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 claims description 3
- 229920001893 acrylonitrile styrene Polymers 0.000 claims description 3
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 229920001778 nylon Polymers 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 229920002239 polyacrylonitrile Polymers 0.000 claims description 3
- 229920000728 polyester Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 229920006124 polyolefin elastomer Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- SCUZVMOVTVSBLE-UHFFFAOYSA-N prop-2-enenitrile;styrene Chemical compound C=CC#N.C=CC1=CC=CC=C1 SCUZVMOVTVSBLE-UHFFFAOYSA-N 0.000 claims description 3
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 claims description 3
- 229920003169 water-soluble polymer Polymers 0.000 claims description 3
- 229920001328 Polyvinylidene chloride Polymers 0.000 claims description 2
- 230000002093 peripheral effect Effects 0.000 claims description 2
- 239000005033 polyvinylidene chloride Substances 0.000 claims description 2
- 229920002545 silicone oil Polymers 0.000 claims description 2
- 239000004416 thermosoftening plastic Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 description 13
- 239000005060 rubber Substances 0.000 description 9
- 229920005549 butyl rubber Polymers 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 238000004073 vulcanization Methods 0.000 description 3
- RAHZWNYVWXNFOC-UHFFFAOYSA-N Sulphur dioxide Chemical compound O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229920005601 base polymer Polymers 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- -1 for example Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000012815 thermoplastic material Substances 0.000 description 1
- 239000004636 vulcanized rubber Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
この発明は採血管に係り、特に栓体部分を改良
した減圧採血管に関する。
〔従来技術〕
減圧採血管はできるだけ長時間に亘り、内部減
圧度を維持するため並びに針刺通後の自己シール
性を確保するため、栓体としてガス透過係数の比
較的低いイソブチレン−イソプレンゴム（IIR）
等のゴム栓が従来使用されている。
〔従来技術の問題点〕
しかし、このゴムのベースとなるポリマーはそ
れ自身では製品として必要な物性を持つていない
ために以下に記すような加工を施して欠点を補つ
ている。まず、ベースポリマーを素練りして硫
黄、加硫促進剤、充填剤、老化防止剤等の助剤を
添加して塑性混合物となし、これを金型に入れて
加熱および加圧して加硫し、打抜きして得られた
ゴム成形体を洗浄し、採血管に挿入し易いように
シリコーンコートが施されている。このように、
従来のゴム栓の製造には、大がかりな設備で複雑
な工程を経て長時間を要するばかりか、添加剤の
調整管理および生産に多くの人手を要するため
に、ゴム栓の生産性が悪く、高価なものとなつて
いた。また、この方法では再生利用のできないバ
リ部分が多く、生産ロスも大きくなつており、こ
の加硫ゴム栓の廃棄処理に際して燃焼処分すると
亜硫酸ガスを発生するという公衆衛生上の問題も
あつた。ゴム栓の形状設計上の点では、IIR等の
ガス透過係数により必然的に形状および体積が決
定され、その形状上の選択範囲は極めて狭かつた
のである。
さらに、このゴム材ベースポリマーに添加され
る上記種々の薬剤は極く微量であるが、経時的に
製品表面に移行し、減圧採血管内薬品の変質、ガ
ラス管表面状態の変質、ゴム表面への血餅の付
着、加硫促進剤および酸化亜鉛、酸化マグネシウ
ムの添加による血漿の生化学分析への妨害等、多
くの弊害を伴うという問題があつた。
発明の目的
本発明の目的は上述した従来のゴム栓に伴う多
くの欠点を解消し、製造が簡単で短時間で行わ
れ、加硫におけるような添加剤を使用せず、減圧
度の保持性が良く、採血血液の分析に悪影響を及
ぼさない信頼性の大きな採血管を提供することで
ある。
すなわち、この発明は管体の一端が開口し、他
端が閉塞した採血管本体と、該管本体の開口部を
密封する熱可塑性エラストマー製栓体と；上記栓
体の底面と上記管本体の上端縁部との間、又は上
記栓体の底面と上記管本体の上記開口部の管内壁
を横切る面に設けられた水平もしくは勾配をなす
段部との間に、該栓体と該管本体内部雰囲気とが
全く接触しないようにして、実質的に平坦状に保
持され、栓体と該管本体内部雰囲気とを気密的に
隔離するガスバリヤー性フイルム体と；
を具備してなることを特徴とする採血管を提供す
るものである。
さらに、この発明は上記ガスバリヤー性フイル
ム体が上記栓体の底面と上記管本体の上記開口部
の管内壁を横切る面に設けられた水平又は勾配を
なす段部との間に挾持されてなる上記採血管を提
供するものである。
さらに、この発明は上記ガスバリヤー性フイル
ム体が上記栓体底面に一体的に形成されている上
記採血管を提供するものである。
さらに、この発明は上記開口部がその外周面に
段部が形成され、この段部に栓体のすそ部が嵌合
してガスバリヤー性フイルムを管本体方向に押圧
するようにした上記採血管を提供するものであ
る。
さらに、この発明は上記栓体が硬度（シヨアー
Ａ）65以下、圧縮永久歪（70℃、22時間）60％以
下の熱可塑性エラストマー、たとえばポリオレフ
イン系エラストマー、スチレンブタジエンスチレ
ンエラストマー又は軟質塩化ビニル系エラストマ
ーがつくられている上記採血管を提供するもので
ある。
さらに、この発明は上記ガスバリヤー性フイル
ム体がガス透過係数（O2、30℃）が0.1×10-10
（c.c.・cm／cm2・sec・cmHg）以下のフイルム、た
とえばエチレンビニルアルコール共重合体、セロ
ハン、ポリビニルアルコール、サツカライド系水
溶性ポリマー又は塩化ビニリデンからつくられ、
その厚みが10〜400μｍである上記採血管を提供
するものである。
さらに、この発明は上記採血管本体が熱可塑性
プラスチツク材料、たとえば、熱可塑性プラスチ
ツクがポリメチルメタクリレート、アクリロニト
リルスチレン共重合体、ポリアクリロニトリル、
エチレンビニルアルコール共重合体、ナイロン又
はポリエステルからつくられているもので上記採
血管を提供するものである。
発明の具体的説明
以下、この発明の採血管を図示の実施例を参照
して説明する。
図中、１は採血管本体であつて、一端が閉塞す
るとともに他端が開口した管体をなし、その開口
端に熱可塑性エラストマーからなる栓体２が嵌挿
されている。この栓体２の底面にはガス透過係数
の小さいガスバリヤー性フイルム体３が一体的に
被着されていて、その周縁部が採血管本体１の開
口部近傍の内壁に設けられた段部４上に圧着され
ている。採血管内は減圧されてなくとも使用可能
であるが、減圧されていることが操作上より好ま
しい。
このような構成に係わる減圧採血管においては
管本体１内の真空度の維持は管本体１の壁面を除
外して考えると、ガスバリヤー性フイルム体３の
みによつて十分に果すことができるので、栓体２
の材質としては穿刺が容易であつて、かつ適当な
弾性を有し、自己シール性があればよく、ガス透
過係数については特に制限を受けないので広い範
囲の熱可塑性エラストマーを使用することができ
る。したがつて、栓体２として、硬度（シヨアー
Ａ）65以下、圧縮永久歪み（70℃、22時間）60％
以下のもの、たとえばポリオレフイン系エラスト
マー、スチレンブタジエンスチレンエラストマ
ー、軟質塩化ビニル系エラストマー等を使用する
ことができる。
管本体１内の真空度を維持するためのガスバリ
ヤー性フイルム体３はガス透過係数ができるだけ
小さく、血液に対して悪影響を与えず、かつ採血
針を容易に刺通させ得るものであればよい。具体
的には、このフイルム体３はガス透過係数（O2、
30℃）が0.1×10-10（c.c.・cm／cm2・sec・cmHg）以
下、好ましくは0.01×10-10（c.c.・cm／cm2・sec・cm
Hg）以下のものを選ぶ。具体的にはエチレンビ
ニルアルコール共重合体、セロハン、ポリビニル
アルコール、サツカライド系水溶性ポリマー、ポ
リ塩化ビニリデンから選ばれる材質がフイルム体
３として用いることができる。フイルム体３の厚
みは使用する材質のガス透過度、針穿刺性等を考
慮して決めればよいが、一般的には10〜400μｍ
の範囲のものが使用される。
採血管本体１の材質としては従来の如きガラス
のほか、熱可塑性プラスチツクを使用することも
できる。熱可塑性プラスチツクを使用する場合は
成形性、製造費等の点で有利であるが、その場
合、ガス透過率の比較的小さいものを使用するこ
とが望ましい。その具体的材料としてはポリメチ
ルメタクリレート、アクリロニトリルスチレン共
重合体、ポリアクリロニトリル、エチレンビニル
アルコール共重合体、ナイロン、ポリエステル等
を挙げることができる。
なお、ガスバリヤー性フイルム体３は上述の如
く栓体２の底面に必ずしも一体的に接着させる必
要はなく、単に栓体２の底面と採血管１本体の段
部４との間に上下方向からの押圧により挟持させ
るようにしてもよい。また、ガスバリヤー性フイ
ルム体３はその特性上、比較的固く、弾性に乏し
いものが用いられるので、シリコーンオイル等の
不乾性の液状シール材を該フイルム体３と段部４
との間に塗布してガスバリヤー性を一層向上させ
るようにしてもよい。
次に、第１図に示す構造の減圧採血管であつて
内径12mm、内部容積11.9mlのものを、下記表の材
料の組合せで構成し、０時間10mlの吸収量（20
℃）として１年後（20℃）の吸収量を測定し、減
圧採血管の内部圧力の経時変化を調べた。
The present invention relates to a blood collection tube, and more particularly to a reduced pressure blood collection tube with an improved stopper portion. [Prior art] In order to maintain the degree of internal vacuum for as long as possible and to ensure self-sealing properties after needle penetration, vacuum blood collection tubes are made of isobutylene-isoprene rubber (with a relatively low gas permeability coefficient) as a stopper. IIR)
Conventionally, rubber stoppers such as [Problems with the Prior Art] However, the polymer that is the base of this rubber does not have the necessary physical properties as a product by itself, so the following processing is performed to compensate for the drawbacks. First, the base polymer is masticated and auxiliary agents such as sulfur, vulcanization accelerators, fillers, and anti-aging agents are added to form a plastic mixture, which is then placed in a mold and vulcanized by heating and pressure. The rubber molded body obtained by punching is washed and coated with silicone so that it can be easily inserted into a blood collection tube. in this way,
Conventional manufacturing of rubber stoppers not only requires large-scale equipment and complicated processes and takes a long time, but also requires a lot of manpower to adjust and manage additives and produce, making rubber stoppers low in productivity and expensive. It had become a thing. In addition, this method has many burrs that cannot be recycled, resulting in large production losses, and there is also a public health problem in that sulfur dioxide gas is generated when the vulcanized rubber stopper is disposed of by combustion. When designing the shape of a rubber stopper, the shape and volume are inevitably determined by the gas permeability coefficient such as IIR, and the range of choices regarding the shape is extremely narrow. Furthermore, although the amount of the various drugs added to the rubber material base polymer is extremely small, they migrate to the product surface over time, causing changes in the quality of the chemicals in the vacuum blood collection tube, changes in the surface condition of the glass tube, and damage to the rubber surface. There have been many problems with this method, including adhesion of blood clots and interference with biochemical analysis of plasma due to the addition of vulcanization accelerators, zinc oxide, and magnesium oxide. OBJECTS OF THE INVENTION The objects of the present invention are to eliminate many of the drawbacks associated with the conventional rubber stoppers mentioned above, to be simple and quick to manufacture, to avoid the use of additives as in vulcanization, and to maintain the degree of reduced pressure. To provide a highly reliable blood collection tube that has good performance and does not adversely affect the analysis of collected blood. That is, the present invention includes a blood collection tube body with one end open and the other end closed; a stopper made of thermoplastic elastomer that seals the opening of the tube body; or between the bottom surface of the plug and a horizontal or sloped step provided on a surface that crosses the inner wall of the opening of the tube body, the plug and the tube body. a gas barrier film body that is held substantially flat without any contact with the internal atmosphere and airtightly isolates the stopper from the internal atmosphere of the tube body; The purpose of the present invention is to provide blood collection tubes with the following functions. Further, in the present invention, the gas barrier film body is sandwiched between the bottom surface of the stopper body and a horizontal or sloped stepped portion provided on a surface crossing the inner wall of the tube of the opening of the tube body. The present invention provides the blood collection tube described above. Furthermore, the present invention provides the blood collection tube described above, in which the gas barrier film is integrally formed on the bottom surface of the stopper. Furthermore, the present invention provides the blood collection tube in which the opening has a step formed on its outer circumferential surface, and the base of the stopper fits into the step to press the gas barrier film toward the tube body. It provides: Furthermore, the present invention provides that the plug body is made of a thermoplastic elastomer having a hardness (Shore A) of 65 or less and a compression set (70°C, 22 hours) of 60% or less, such as a polyolefin elastomer, a styrene-butadiene styrene elastomer, or a soft vinyl chloride elastomer. The present invention provides the above-mentioned blood collection tube in which the above blood collection tube is manufactured. Furthermore, the present invention provides that the gas barrier film has a gas permeability coefficient (O 2 , 30°C) of 0.1×10 -10
(cc・cm/cm 2・sec・cmHg) The following films are made from ethylene vinyl alcohol copolymer, cellophane, polyvinyl alcohol, saccharide water-soluble polymer or vinylidene chloride,
The present invention provides the above blood collection tube having a thickness of 10 to 400 μm. Furthermore, the present invention provides that the blood collection tube body is made of a thermoplastic material, for example, the thermoplastic is polymethyl methacrylate, acrylonitrile styrene copolymer, polyacrylonitrile,
The blood collection tube is made of ethylene vinyl alcohol copolymer, nylon, or polyester. DETAILED DESCRIPTION OF THE INVENTION The blood collection tube of the present invention will be described below with reference to illustrated embodiments. In the figure, reference numeral 1 denotes a blood collection tube main body, which is a tubular body with one end closed and the other end open, and a stopper 2 made of thermoplastic elastomer is fitted into the open end. A gas barrier film body 3 having a small gas permeability coefficient is integrally attached to the bottom surface of the stopper body 2, and its peripheral edge forms a step portion 4 provided on the inner wall near the opening of the blood collection tube body 1. It is crimped on top. Although it is possible to use the blood collection tube even if the pressure is not reduced, it is more preferable from the viewpoint of operation that the pressure be reduced. In a vacuum blood collection tube with such a configuration, the degree of vacuum within the tube body 1 can be sufficiently maintained only by the gas barrier film body 3, excluding the wall surface of the tube body 1. , plug body 2
The material only needs to be one that is easy to puncture, has appropriate elasticity, and has self-sealing properties, and there are no particular restrictions on the gas permeability coefficient, so a wide range of thermoplastic elastomers can be used. . Therefore, the plug body 2 has a hardness (Shor A) of 65 or less and a compression set (70°C, 22 hours) of 60%.
The following materials can be used, such as polyolefin elastomers, styrene-butadiene styrene elastomers, and soft vinyl chloride elastomers. The gas barrier film body 3 for maintaining the degree of vacuum within the tube body 1 may be any material as long as it has a gas permeability coefficient as low as possible, does not have an adverse effect on blood, and can be easily penetrated by a blood collection needle. . Specifically, this film body 3 has a gas permeability coefficient (O 2 ,
30℃) is 0.1×10 -10 (cc・cm/cm 2・sec・cmHg) or less, preferably 0.01×10 −10 (cc・cm/cm 2・sec・cm
Hg) Select the following. Specifically, a material selected from ethylene vinyl alcohol copolymer, cellophane, polyvinyl alcohol, saccharide water-soluble polymer, and polyvinylidene chloride can be used as the film body 3. The thickness of the film body 3 may be determined by considering the gas permeability of the material used, needle puncture resistance, etc., but it is generally 10 to 400 μm.
range is used. As the material for the blood collection tube body 1, in addition to conventional glass, thermoplastic plastic can also be used. The use of thermoplastic plastics is advantageous in terms of moldability, manufacturing costs, etc., but in that case, it is desirable to use a material with relatively low gas permeability. Specific examples of the material include polymethyl methacrylate, acrylonitrile styrene copolymer, polyacrylonitrile, ethylene vinyl alcohol copolymer, nylon, and polyester. Note that the gas barrier film body 3 does not necessarily have to be integrally adhered to the bottom surface of the stopper body 2 as described above, but is simply attached from the top and bottom between the bottom surface of the stopper body 2 and the stepped portion 4 of the main body of the blood collection tube 1. Alternatively, the material may be held by pressing the material. Furthermore, since the gas barrier film body 3 is relatively hard and has poor elasticity due to its characteristics, a non-drying liquid sealing material such as silicone oil is applied to the film body 3 and the stepped portions 4.
The gas barrier property may be further improved by coating between the two. Next, a vacuum blood collection tube with the structure shown in Figure 1, with an inner diameter of 12 mm and an internal volume of 11.9 ml, was constructed using the combination of materials shown in the table below, and the absorption capacity (20
The absorption amount was measured after one year (at 20°C) and the change over time in the internal pressure of the vacuum blood collection tube was investigated.
【表】【table】
【表】
上記第１図に示す実施例においては採血管本体
１の開口部内壁の段部４をほぼ水平にしたものに
ついて述べたが、これに限らず第２図に示す如
く、内側に向つて下降する勾配を形成させた段部
４ａ、あるいは第３図に示す如く、外側に向つて
下降する勾配を形成させた段部４ｂとしてシール
性を改善するようにしてもよい。また、第４図に
示す如く採血管本体１の開口部内壁に段部を特に
設けずに、その上端縁部５上にガスバリヤー性フ
イルム体３を載置するとともに採血管本体１の開
口部外周に段部６を設け、栓体２にも、これと対
応する鉤部７を設けて、これを段部６に係合させ
て、フイルム体３を上記縁部５上に圧着させるよ
うにしてもよい。
発明の具体的作用効果
この発明によればガスバリヤー性フイルム体を
用いて栓体を採血管本体内部から隔離するように
したから、栓体としてガス透過性に劣るが自己シ
ール性の良好な熱可塑性エラストマーを使用する
ことができ、したがつて、再生利用が可能とな
り、また透明な栓体も可能となり針刺通部を観察
することもできる。さらにブチルゴムを使用した
場合のように栓体から溶出物が出ることがなく検
査値に与える影響がない。また、ガスバリヤー性
フイルム体を採血管本体開口部の段部を利用して
栓体底部と採血管本体との間で押圧するようにし
たから減圧採血管の真空度の経時的変化を著るし
く抑制することができる。
また、栓体への針の刺通抵抗も従来のブチルゴ
ム等に較べ小さいため穿刺操作が容易となる。
さらにガスバリヤー性フイルム体はガス透過度
の抑制のみの役割を果せる材質であればよいか
ら、採血された血液への溶出物の混入等の悪影響
を著るしく改善することが可能となる。[Table] In the embodiment shown in FIG. 1, the stepped portion 4 of the inner wall of the opening of the blood collection tube body 1 is made almost horizontal, but this is not limited to this, and as shown in FIG. The sealing performance may be improved by forming a stepped portion 4a with a slope that descends toward the outside, or a stepped portion 4b with a slope that slopes downward toward the outside as shown in FIG. Further, as shown in FIG. 4, the gas barrier film body 3 is placed on the upper edge 5 of the opening of the blood sampling tube main body 1 without particularly providing a step on the inner wall of the opening of the blood sampling tube main body 1. A stepped portion 6 is provided on the outer periphery, and a corresponding hook portion 7 is provided on the plug body 2, which is engaged with the stepped portion 6 to press the film body 3 onto the edge portion 5. You can. Specific Effects of the Invention According to the present invention, since the gas barrier film is used to isolate the stopper from the inside of the blood collection tube body, the stopper has poor gas permeability but has good self-sealing properties. A plastic elastomer can be used, thus allowing recycling, and a transparent plug is also possible, allowing the needle penetration site to be observed. Furthermore, unlike when butyl rubber is used, eluates do not come out from the plug, so there is no effect on test values. In addition, since the gas barrier film is pressed between the bottom of the stopper and the blood collection tube body using the stepped part of the opening of the blood collection tube body, the degree of vacuum in the vacuum blood collection tube changes over time. can be effectively suppressed. Furthermore, the resistance to needle penetration into the stopper is smaller than that of conventional butyl rubber, making the puncturing operation easier. Furthermore, since the gas barrier film body only needs to be made of a material that can play the role of suppressing gas permeability, it is possible to significantly improve adverse effects such as contamination of collected blood with eluate.
第１図ないし第４図は本発明に係わる減圧採血
管の種々の具体例を示す断面図である。
図中、１……採血管本体、２……栓体、３……
ガスバリヤー性フイルム体、４，４ａ，４ｂ……
段部、５……上端縁部、６……段部、７……鉤
部。
1 to 4 are cross-sectional views showing various specific examples of reduced pressure blood collection tubes according to the present invention. In the figure, 1... Blood collection tube body, 2... Stopper body, 3...
Gas barrier film body, 4, 4a, 4b...
Stepped portion, 5... Upper edge portion, 6... Stepped portion, 7... Hooked portion.
Claims (1)
本体と、 該管本体の開口部を密封する熱可塑性エラスト
マー製栓体と； 上記栓体の底面と上記管本体の上端縁部との
間、又は上記栓体の底面と上記管本体の上記開口
部の管内壁を横切る面に設けられた水平もしくは
勾配をなす段部との間に、該栓体と該管本体内部
雰囲気とが全く接触しないようにして、実質的に
平坦状に保持され、栓体と該管本体内部雰囲気と
を気密的に隔離するガスバリヤー性フイルム体
と； を具備してなることを特徴とする採血管。 ２ 該ガスバリヤー性フイルム体が上記栓体底面
に一体的に形成されている特許請求の範囲第１項
記載の採血管。 ３ 該ガスバリヤー性フイルム体の少なくとも該
管本体との接触部にシリコーンオイルが介在して
いる特許請求の範囲第１項記載の採血管。 ４ 上記開口部はその外周面に段部が形成され、
この段部に栓体の対応するすそ部が嵌合してガス
バリヤー性フイルム体を管本体方向に押圧するよ
うにした特許請求の範囲第１項記載の採血管。 ５ 栓体が硬度（シヨアーＡ）65以下、圧縮永久
歪（70℃、22時間）60％以下の熱可塑性エラスト
マーからつくられている特許請求の範囲第１項記
載の採血管。 ６ 熱可塑性エラストマーがポリオレフイン系エ
ラストマー、スチレンブタジエンスチレンエラス
トマーおよび軟質塩化ビニル系エラストマーから
選ばれるものである特許請求の範囲第５項記載の
採血管。 ７ ガスバリヤー性フイルム体はガス透過係数
（O2、30℃）が0.1×10-10（c.c.・cm／cm2・sec・cm
Hg）以下のフイルムからつくられている特許請
求の範囲第１項記載の採血管。 ８ 該フイルムがエチレンビニルアルコール共重
合体、セロハン、ポリビニルアルコール、サツカ
ライド系水溶性ポリマー、ポリ塩化ビニリデンか
ら選ばれるものである特許請求の範囲第７項記載
の採血管。 ９ 該フイルムの厚みが10〜400μｍである特許
請求の範囲第７項記載の採血管。 １０ 採血管本体が熱可塑性プラスチツクからつ
くられている特許請求の範囲第１項記載の採血
管。 １１ 熱可塑性プラスチツクがポリメチルメタク
リレート、アクリロニトリルスチレン共重合体、
ポリアクリロニトリル、エチレンビニルアルコー
ル共重合体、ナイロン、ポリエステルから選ばれ
るものである特許請求の範囲第１０項記載の採血
管。 １２ 該採血管本体内部雰囲気が減圧されてなる
特許請求の範囲第１ないし第１１項のいずれかに
記載の採血管。[Scope of Claims] 1. A blood collection tube body with one end open and the other end closed; a stopper made of thermoplastic elastomer that seals the opening of the tube body; a bottom surface of the stopper and the tube; between the top edge of the main body or between the bottom surface of the stopper and a horizontal or sloped step provided on a surface that crosses the inner wall of the opening of the pipe body. a gas barrier film body that is held substantially flat without any contact with the internal atmosphere of the tube body, and airtightly isolates the stopper from the internal atmosphere of the tube body; A blood collection tube featuring: 2. The blood collection tube according to claim 1, wherein the gas barrier film is integrally formed on the bottom surface of the stopper. 3. The blood collection tube according to claim 1, wherein silicone oil is present at least in the contact portion of the gas barrier film with the tube body. 4 The opening has a step formed on its outer peripheral surface,
2. The blood collection tube according to claim 1, wherein a corresponding base portion of the stopper fits into the stepped portion to press the gas barrier film toward the tube body. 5. The blood collection tube according to claim 1, wherein the stopper is made of a thermoplastic elastomer having a hardness (Shore A) of 65 or less and a compression set (70° C., 22 hours) of 60% or less. 6. The blood collection tube according to claim 5, wherein the thermoplastic elastomer is selected from polyolefin elastomers, styrene-butadiene styrene elastomers, and soft vinyl chloride elastomers. 7 The gas barrier film has a gas permeability coefficient (O 2 , 30℃) of 0.1×10 -10 (cc・cm/cm 2・sec・cm
Hg) The blood collection tube according to claim 1, which is made from the following film: 8. The blood collection tube according to claim 7, wherein the film is selected from ethylene vinyl alcohol copolymer, cellophane, polyvinyl alcohol, saccharide water-soluble polymer, and polyvinylidene chloride. 9. The blood collection tube according to claim 7, wherein the film has a thickness of 10 to 400 μm. 10. The blood collection tube of claim 1, wherein the blood collection tube body is made of thermoplastic plastic. 11 The thermoplastic is polymethyl methacrylate, acrylonitrile styrene copolymer,
The blood collection tube according to claim 10, which is selected from polyacrylonitrile, ethylene vinyl alcohol copolymer, nylon, and polyester. 12. The blood collection tube according to any one of claims 1 to 11, wherein the internal atmosphere of the blood collection tube body is reduced in pressure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57166226A JPS5955240A (en) | 1982-09-24 | 1982-09-24 | Blood sampling tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57166226A JPS5955240A (en) | 1982-09-24 | 1982-09-24 | Blood sampling tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5955240A JPS5955240A (en) | 1984-03-30 |
| JPS644454B2 true JPS644454B2 (en) | 1989-01-25 |
Family
ID=15827445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57166226A Granted JPS5955240A (en) | 1982-09-24 | 1982-09-24 | Blood sampling tube |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5955240A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0328866A (en) * | 1989-06-26 | 1991-02-07 | Fujitsu Ltd | Developing device |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61128944A (en) * | 1984-11-27 | 1986-06-17 | テルモ株式会社 | Vacuum blood sampler |
| JPS61176328A (en) * | 1985-01-29 | 1986-08-08 | 積水化学工業株式会社 | Vacuum blood sampling tube |
| JPS63315033A (en) * | 1987-06-18 | 1988-12-22 | Terumo Corp | Method and apparatus for collecting blood specimen |
| US5494170A (en) * | 1993-05-06 | 1996-02-27 | Becton Dickinson And Company | Combination stopper-shield closure |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5759536A (en) * | 1980-09-27 | 1982-04-09 | Terumo Corp | Rubber gasket for vacuum blood sampling tube |
-
1982
- 1982-09-24 JP JP57166226A patent/JPS5955240A/en active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0328866A (en) * | 1989-06-26 | 1991-02-07 | Fujitsu Ltd | Developing device |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5955240A (en) | 1984-03-30 |
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