JPS645497A - Collection of peptide - Google Patents
Collection of peptideInfo
- Publication number
- JPS645497A JPS645497A JP16035687A JP16035687A JPS645497A JP S645497 A JPS645497 A JP S645497A JP 16035687 A JP16035687 A JP 16035687A JP 16035687 A JP16035687 A JP 16035687A JP S645497 A JPS645497 A JP S645497A
- Authority
- JP
- Japan
- Prior art keywords
- trypsin
- casein
- peptide
- angiotensin
- fraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004142 Trypsin Human genes 0.000 abstract 3
- 108090000631 Trypsin Proteins 0.000 abstract 3
- 239000005018 casein Substances 0.000 abstract 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 3
- 235000021240 caseins Nutrition 0.000 abstract 3
- 239000012588 trypsin Substances 0.000 abstract 3
- 108010064733 Angiotensins Proteins 0.000 abstract 2
- 102000015427 Angiotensins Human genes 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000000413 hydrolysate Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 230000001131 transforming effect Effects 0.000 abstract 2
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE:To enable the collection of a large amount of a peptide inhibiting enzyme transforming angiotensin simply and rapidly, by hydrolyzing casein with trypsin and dialyzing the hydrolysate against a dialyzing membrane of less than 8,000 fraction mol.wt. CONSTITUTION:Bovine casein is hydrolyzed with trypsin and the hydrolysate is treated with heat or acid to remove trypsin and unhydrolyzed casein by precipitation. The solution is dialyzed in a membrane tube of less than 8,000 fraction mol.wt. against flowing water at room temperature in a usual manner. The dialysate is centrifuged to remove insoluble fraction, freeze-dried to give a white powder of peptide inhibiting enzyme transforming angiotensin (ACE- inhibitor peptide). This process gives the protein simply, rapidly with separation of contaminants improved in high yield. The product originates from nature, thus having high safety and can be practically used as an oral preparation having hypotensive action.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16035687A JPS645497A (en) | 1987-06-27 | 1987-06-27 | Collection of peptide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16035687A JPS645497A (en) | 1987-06-27 | 1987-06-27 | Collection of peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS645497A true JPS645497A (en) | 1989-01-10 |
Family
ID=15713204
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16035687A Pending JPS645497A (en) | 1987-06-27 | 1987-06-27 | Collection of peptide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS645497A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995028425A1 (en) * | 1994-04-19 | 1995-10-26 | Kanebo, Ltd. | Preventive for circulatory diseases |
| US6232438B1 (en) | 1996-01-11 | 2001-05-15 | Nong Shim Co., Ltd. | Angiotensin converting enzyme inhibitors |
| KR100470456B1 (en) * | 2001-07-02 | 2005-02-05 | 대한민국 | Antihypertensive casein protein hydrolysate and manufacturing method thereof |
| WO2006114193A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having an ace inhibiting effect |
| WO2006114194A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having a health benefit and compositions comprising them |
| WO2006114192A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having an ace inhibiting effect |
| JP2010539029A (en) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | Use of gluten exorphin C as a therapeutic agent |
-
1987
- 1987-06-27 JP JP16035687A patent/JPS645497A/en active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995028425A1 (en) * | 1994-04-19 | 1995-10-26 | Kanebo, Ltd. | Preventive for circulatory diseases |
| US6232438B1 (en) | 1996-01-11 | 2001-05-15 | Nong Shim Co., Ltd. | Angiotensin converting enzyme inhibitors |
| KR100470456B1 (en) * | 2001-07-02 | 2005-02-05 | 대한민국 | Antihypertensive casein protein hydrolysate and manufacturing method thereof |
| WO2006114193A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having an ace inhibiting effect |
| WO2006114194A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having a health benefit and compositions comprising them |
| WO2006114192A1 (en) * | 2005-04-28 | 2006-11-02 | Unilever N.V. | Peptides having an ace inhibiting effect |
| JP2010539029A (en) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | Use of gluten exorphin C as a therapeutic agent |
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