JPS645567B2 - - Google Patents
Info
- Publication number
- JPS645567B2 JPS645567B2 JP456884A JP456884A JPS645567B2 JP S645567 B2 JPS645567 B2 JP S645567B2 JP 456884 A JP456884 A JP 456884A JP 456884 A JP456884 A JP 456884A JP S645567 B2 JPS645567 B2 JP S645567B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- carbon dioxide
- dioxide gas
- nourishing
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 55
- 239000001569 carbon dioxide Substances 0.000 claims description 27
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- 239000011159 matrix material Substances 0.000 claims description 15
- 239000012190 activator Substances 0.000 claims description 11
- 230000012010 growth Effects 0.000 claims description 5
- 230000003779 hair growth Effects 0.000 description 14
- 230000000694 effects Effects 0.000 description 10
- 239000007788 liquid Substances 0.000 description 5
- 210000004761 scalp Anatomy 0.000 description 4
- 230000000304 vasodilatating effect Effects 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- 208000024963 hair loss Diseases 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000002826 placenta Anatomy 0.000 description 2
- 229930002330 retinoic acid Natural products 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N 1,1-Diethoxyethane Chemical compound CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- 125000005274 4-hydroxybenzoic acid group Chemical class 0.000 description 1
- 238000011735 C3H mouse Methods 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000011354 acetal resin Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- TUFYVOCKVJOUIR-UHFFFAOYSA-N alpha-Thujaplicin Natural products CC(C)C=1C=CC=CC(=O)C=1O TUFYVOCKVJOUIR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960005261 aspartic acid Drugs 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 229930002875 chlorophyll Natural products 0.000 description 1
- 235000019804 chlorophyll Nutrition 0.000 description 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- -1 etc. Substances 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- VUOLWBPDWWANLX-FJXQXJEOSA-M potassium 3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [K+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O VUOLWBPDWWANLX-FJXQXJEOSA-M 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
本発明は養毛・育毛料に関し、更に詳しくは毛
母細胞賦活剤及び炭酸ガスを配合した養毛・育毛
料に関する。
従来より養毛・育毛料には毛母細胞賦活作用を
有する合成又は天然物抽出エキス等が適用されて
いるが、少量の添加では充分な効果が得られず、
また多量に配合するとある程度効果が得られるも
のの適用部位に不快な刺激感を与え、さらに連続
使用すると皮膚炎を起こす等の欠点があつた。
一方炭酸ガスは血管拡張作用を有することが知
られており、臨床的にも炭酸ガス浴としてリハビ
リテーシヨンなどに使用されている。
そこで、本発明者は、炭酸ガスを養毛・育毛料
に配合することに着目し種々研究を行なつた結
果、養毛・育毛料に毛母細胞賦活剤と炭酸ガスを
併用すれは、頭皮の毛細血管が拡張し、毛母細胞
賦活剤が効率よく毛母に到達し、毛母細胞の働き
を活発化し、頭髪の脱毛の減少及び頭髪の成長を
促進できることを見出し、本発明を完成した。
すなわち、本発明は毛母細胞賦活剤を含有する
養毛・育毛料に炭酸ガスを配合して耐圧容器に密
着した養毛・育毛料を提供するものである。
本発明に使用される毛母細胞賦活剤としては、
合成又は天然成分である、ビタミンＡ酸、パント
テン酸及びその誘導体、パントテニールアルコー
ル及びその誘導体、ｌ−アスパラギン酸及びその
誘導体、感光素301号、エチニルエストラジオー
ル、プラセンタエキス、鉄クロロフイルなどが挙
げられるが、このうち、ビタミンＡ酸、パントテ
ン酸カリウム、パントテニールアルコール、プラ
センタエキスが特に好ましい。この毛母細胞賦活
剤は、水又は水−低級アルコール等の溶媒に配合
して使用される。毛母細胞賦活剤は本発明の養
毛・育毛剤中に0.001〜５重量％（以下単に％で
示す）配合するのが好ましい。0.001％以下では
充分な効果が得られず、また５％以上配合すると
頭皮に不快な刺激感を与え好ましくない。
ところで、炭酸ガスは、これが溶解している溶
液のPHが酸性の場合にはCO2分子として存在し、
血管拡張作用を示すことが知られている。従つ
て、本発明の養毛・育毛料の液性はPH７以下、特
にPH4.5〜6.5に調整するのが好ましい。なお、養
毛・育毛料のPHは炭酸ガスが圧入され、これが養
毛・育毛料中に溶け込むと更に酸性度が強くなる
が、最終PHが上記範囲にるように調節すればよ
い。このPH調節剤としては、例えばクエン酸、酒
石酸、乳酸等の有機酸又はこれらの塩、あるいは
リン酸又はその塩が好適に使用される。炭酸ガス
を養毛・育毛料に配合するには、養毛・育毛料を
耐圧容器に入れ、これに高圧ガスを封入する方
法、耐圧容器に炭酸水素ナトリウム等の炭酸塩を
含ませた養毛・育毛料を入れ、これにPH調節剤を
加えて炭酸ガスを発生させ、直ちに密封する方
法、あるいはドライアイスペレツトを容器内に入
れて密封する方法等が採用されるが、就中特に高
圧ガスを封入する方法が好ましい。
このようにするとき、炭酸ガスの一部は養毛・
育毛料中に溶解して配合され、また一部は容器中
に気体として存在する。本発明においては炭酸ガ
スが養毛・育毛料中に溶けて配合されていること
が重要であり、この配合量は炭酸ガス濃度が
60ppm以上であることが好ましく、これより少な
いと充分な血管拡張作用を期待できず、本発明の
効果は得られない。炭酸ガスの配合量の調節は、
炭酸ガスの注入（圧入）量によつて行うことがで
き、一般には容器中の圧力が35℃の温度で1.2〜
８Kg／cm2（ゲージ圧）になるようにするのが好ま
しい。
また、本発明で使用される耐圧容器は、調製後
使用されるまで上記圧力に耐えて養毛・育毛料を
密封状態で保持できるものであることが必要であ
り、例えばアルミ、ブリキ等の金属容器、アセタ
ール系樹脂、ポリカーボネート系樹脂等の合成樹
脂容器及びガラス容器が用いられる。
一方吐出ノズルはその径が小さいと充填液は霧
状に、大きいと泡状又は液状に噴射される。噴射
形態は、また缶内圧によつても異なるが、一般に
エアゾール噴霧容器の吐出ノズルの径は0.3mm以
下であり、これを本発明の養毛・育毛料に適用し
た場合、霧状に噴霧されて炭酸ガスがすぐ飛散し
てしまうので充分な効果が得られない。本発明の
効果をより高めるためには、養毛・育毛料中の炭
酸ガスの滞留時間を長くする必要があり、本発明
養毛・育毛料を頭髪に付着することなく、頭皮に
直接泡状又は液状で塗布し、頭皮上で発泡させる
のが好ましい。このため、吐出ノズルの径を0.3
〜1.5mm、長さを１〜15cmにすることが好ましい。
更に使用に伴なう缶内圧の減少による炭酸ガスの
溶解量の減少を防ぎ、又噴射状態を一定に保つた
めに、容器中に炭酸ガスのミニボンベを内蔵し、
使用時圧力が低下した場合に、新たに炭酸ガスを
供給する特開昭57−153752号のようなエアゾール
噴射装置と組み合わせることが好ましい。斯くす
れば、使用当初から使用終了まで炭酸ガス濃度を
一定に維持することができる。
本発明の養毛・育毛料には上記必須成分のほか
に、通常の化粧料に使用される油性基剤、エモリ
エント剤、ゲル化剤、各種乳化剤、香料、パラヒ
ドロキシ安息香酸エステル等の防腐剤、ブチルヒ
ドロキシアニソール等の酸化防止剤、染料等の着
色剤、メントール等の清涼剤、ヒノキチオール等
の殺菌剤、プロピレングリコール等の湿潤剤を添
加配合することができる。
叙上の如く、本発明の養毛・育毛料は、炭酸ガ
スの血管拡張作用で毛母細胞賦活剤を効率よく毛
母に到達させることができ、優れた養毛・育毛効
果及び脱毛抑止効果を示す。また炭酸ガスを併用
することにより刺激性の強い毛母細胞賦活剤の配
合量を少なくできるので、連続使用が可能とな
り、上記効果をより高めることができる。更に、
炭酸ガスの発泡効果により頭皮に快適な刺激感及
びマツサージ効果を与えることができ、また養
毛・育毛料自体のPHが弱酸性であるので皮膚のPH
に近くなり、皮膚に好ましい影響を与えることが
できる。
次に実施例を挙げて本発明を説明する。
参考例 １
C3Hマウス（〓）の休止期にある背部皮膚の
毛を皮膚を傷つけないように刈り、次期成長期毛
の成長を観察した。皮膚表面上に毛の成長を認め
た部位の面積を経日的に測定し、その刈毛部の面
積に対する割合（ｒ）を求めた。結果を第１表に
示す。
The present invention relates to a hair nourishing/growth agent, and more particularly to a hair nourishing/hair growing agent containing a hair matrix cell activator and carbon dioxide gas. Conventionally, synthetic or natural product extracts that have a hair matrix activation effect have been applied to hair nourishing and restoring products, but adding a small amount does not provide sufficient effects.
In addition, although it is effective to some extent when added in large amounts, it gives an unpleasant irritating feeling to the application site, and furthermore, continuous use causes dermatitis. On the other hand, carbon dioxide gas is known to have a vasodilating effect, and is clinically used as a carbon dioxide gas bath for rehabilitation. Therefore, the present inventor focused on incorporating carbon dioxide gas into hair nourishing and hair growth products, and as a result of conducting various researches, the inventor found that the combination of a hair matrix cell activator and carbon dioxide gas in hair nourishing and hair growth products is effective for the scalp. The present invention was completed based on the discovery that the capillaries of the hair expand, the hair matrix cell activator efficiently reaches the hair matrix, activates the function of the hair matrix, reduces hair loss, and promotes hair growth. . That is, the present invention provides a hair nourishing and hair restoring material which is made by blending carbon dioxide gas into a hair nourishing and hair restoring material containing a hair matrix cell activator and which is adhered to a pressure-resistant container. The hair matrix cell activator used in the present invention includes:
Synthetic or natural ingredients such as vitamin A acid, pantothenic acid and its derivatives, pantothenyl alcohol and its derivatives, l-aspartic acid and its derivatives, photosensor No. 301, ethinyl estradiol, placenta extract, iron chlorophyll, etc. Among these, vitamin A acid, potassium pantothenate, pantothenyl alcohol, and placenta extract are particularly preferred. This hair matrix cell activator is used by blending it with a solvent such as water or water-lower alcohol. The hair matrix cell activator is preferably blended in the hair nourishing and restoring agent of the present invention in an amount of 0.001 to 5% by weight (hereinafter simply expressed as %). If it is less than 0.001%, a sufficient effect cannot be obtained, and if it is more than 5%, it gives an unpleasant irritation to the scalp, which is undesirable. By the way, carbon dioxide gas exists as CO 2 molecules when the pH of the solution in which it is dissolved is acidic.
It is known to exhibit vasodilatory effects. Therefore, it is preferable that the liquid nature of the hair nourishing/restorer of the present invention is adjusted to pH 7 or lower, particularly pH 4.5 to 6.5. Note that the pH of the hair nourishing/hair growing agent becomes even more acidic when carbon dioxide gas is pressurized and dissolved in the hair nourishing/hair growing agent, but the final pH may be adjusted to be within the above range. As the PH regulator, organic acids such as citric acid, tartaric acid, and lactic acid or salts thereof, or phosphoric acid or salts thereof are preferably used. To incorporate carbon dioxide gas into a hair growth product, put the hair growth product into a pressure-resistant container and fill it with high-pressure gas.・Putting a hair growth agent, adding a PH regulator to generate carbon dioxide gas, and immediately sealing the container, or placing dry ice pellets in a container and sealing the container, are used, but especially high-pressure gas A method of encapsulating is preferred. When doing this, some of the carbon dioxide gas is used for hair growth and
It is dissolved and blended into the hair growth agent, and a portion is present in the container as a gas. In the present invention, it is important that carbon dioxide is dissolved in the hair nourishing and hair growth agent, and the amount of carbon dioxide gas to be added is determined by adjusting the carbon dioxide concentration.
It is preferable that the amount is 60 ppm or more; if it is less than this, a sufficient vasodilatory effect cannot be expected and the effects of the present invention cannot be obtained. To adjust the amount of carbon dioxide gas,
This can be done by adjusting the amount of carbon dioxide gas injected (injected), and generally the pressure in the container is 1.2 to 1.2 at a temperature of 35℃.
It is preferable to adjust the pressure to 8 Kg/cm 2 (gauge pressure). In addition, the pressure-resistant container used in the present invention must be able to withstand the above-mentioned pressure and keep the hair growth agent in a sealed state until it is used after preparation, and for example, it must be made of metal such as aluminum or tin. Containers, synthetic resin containers such as acetal resin, polycarbonate resin, etc., and glass containers are used. On the other hand, if the diameter of the discharge nozzle is small, the filling liquid is sprayed in the form of mist, and if the diameter is large, the filling liquid is sprayed in the form of foam or liquid. The spray form also differs depending on the internal pressure of the can, but generally the diameter of the discharge nozzle of an aerosol spray container is 0.3 mm or less, and when this is applied to the hair nourishing/growth agent of the present invention, the spray is atomized in the form of a mist. Since the carbon dioxide gas immediately scatters, the sufficient effect cannot be obtained. In order to further enhance the effects of the present invention, it is necessary to lengthen the residence time of carbon dioxide gas in the hair nourishing and restoring agent. Alternatively, it is preferable to apply it in liquid form and foam it on the scalp. For this reason, the diameter of the discharge nozzle was set to 0.3
~1.5 mm, preferably 1 to 15 cm in length.
Furthermore, in order to prevent the amount of dissolved carbon dioxide gas from decreasing due to the decrease in the internal pressure of the can due to use, and to maintain a constant injection condition, a mini cylinder of carbon dioxide gas is built into the container.
It is preferable to combine it with an aerosol injection device such as that disclosed in JP-A-57-153752, which supplies new carbon dioxide gas when the pressure during use decreases. In this way, the carbon dioxide concentration can be maintained constant from the beginning of use until the end of use. In addition to the above-mentioned essential ingredients, the hair nourishing and restoring agent of the present invention contains oil bases, emollients, gelling agents, various emulsifiers, fragrances, and preservatives such as parahydroxybenzoic acid esters, which are commonly used in cosmetics. , an antioxidant such as butylhydroxyanisole, a coloring agent such as a dye, a cooling agent such as menthol, a bactericidal agent such as hinokitiol, and a wetting agent such as propylene glycol can be added. As mentioned above, the hair nourishing and restoring agent of the present invention can efficiently deliver the hair matrix cell activator to the hair matrix due to the vasodilatory action of carbon dioxide gas, and has excellent hair nourishing and hair growth effects and hair loss inhibiting effects. shows. Furthermore, by using carbon dioxide gas in combination, the amount of the highly irritating hair matrix cell activator can be reduced, allowing continuous use and further enhancing the above-mentioned effects. Furthermore,
The bubbling effect of carbon dioxide gas can provide a comfortable stimulation sensation and pine surge effect to the scalp, and since the PH of the hair growth agent itself is slightly acidic, it can reduce the PH of the skin.
, and can have a positive effect on the skin. Next, the present invention will be explained with reference to Examples. Reference Example 1 The hair on the dorsal skin in the telogen phase of C3H mice (〓) was clipped without damaging the skin, and the growth of the next anagen hair was observed. The area of the area where hair growth was observed on the skin surface was measured over time, and the ratio (r) to the area of the shaved area was determined. The results are shown in Table 1.
【表】
成長期毛成長面積
＊ r＝[Table] Anagen hair growth area
*r＝
Claims (1)
酸ガスを配合して耐圧容器に密封したことを特徴
とする養毛・育毛料。 ２ PHが７以下である特許請求の範囲第１項記載
の養毛・育毛料。 ３ 毛母細胞賦活剤の配合量が0.001〜５重量％
である特許請求の範囲第１項記載の養毛・育毛
料。 ４ 炭酸ガスの配合量が60ppm以上である特許請
求の範囲第１項記載の養毛・育毛料。[Scope of Claims] 1. A hair nourishing and hair restoring agent, which is characterized in that a hair nourishing and restoring agent containing a hair matrix cell activator is blended with carbon dioxide gas and sealed in a pressure-resistant container. 2. The hair nourishing/growth agent according to claim 1, which has a pH of 7 or less. 3 The amount of hair matrix cell activator is 0.001 to 5% by weight
The hair nourishing/hair growing agent according to claim 1. 4. The hair nourishing/growth agent according to claim 1, wherein the amount of carbon dioxide gas is 60 ppm or more.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP456884A JPS60149514A (en) | 1984-01-13 | 1984-01-13 | Hair-tonic and hair-restorer |
| DE8484106744T DE3480171D1 (en) | 1983-06-20 | 1984-06-13 | Hair growth promoting composition |
| EP84106744A EP0129197B1 (en) | 1983-06-20 | 1984-06-13 | Hair growth promoting composition |
| AT84106744T ATE47310T1 (en) | 1983-06-20 | 1984-06-13 | HAIR GROWTH STIMULATING AGENT. |
| KR1019840003432A KR910002666B1 (en) | 1983-06-20 | 1984-06-19 | Hair growth promoting composition |
| PH31271A PH19430A (en) | 1984-01-13 | 1984-09-27 | Hair growth promoting composition |
| MYPI87000273A MY100758A (en) | 1983-06-20 | 1987-03-11 | Hair growth promoting composition |
| HK341/91A HK34191A (en) | 1983-06-20 | 1991-05-02 | Hair growth promoting composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP456884A JPS60149514A (en) | 1984-01-13 | 1984-01-13 | Hair-tonic and hair-restorer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60149514A JPS60149514A (en) | 1985-08-07 |
| JPS645567B2 true JPS645567B2 (en) | 1989-01-31 |
Family
ID=11587638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP456884A Granted JPS60149514A (en) | 1983-06-20 | 1984-01-13 | Hair-tonic and hair-restorer |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS60149514A (en) |
| PH (1) | PH19430A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220354761A1 (en) * | 2021-04-30 | 2022-11-10 | L'oreal | Compositions and methods for treating keratin fibers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6011884B2 (en) * | 1979-03-12 | 1985-03-28 | ユルゲン・タム | Cosmetics for hair and skin care |
| JPS5747377A (en) * | 1980-09-02 | 1982-03-18 | Tokyo Aerosol Kagaku Kk | Aerosol spray composition for application to human body |
| EP0257342B1 (en) * | 1986-08-13 | 1992-01-02 | Siemens Aktiengesellschaft | Squid magnetometer for a single or multiple channel, very weak magnetic field measuring apparatus |
-
1984
- 1984-01-13 JP JP456884A patent/JPS60149514A/en active Granted
- 1984-09-27 PH PH31271A patent/PH19430A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220354761A1 (en) * | 2021-04-30 | 2022-11-10 | L'oreal | Compositions and methods for treating keratin fibers |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60149514A (en) | 1985-08-07 |
| PH19430A (en) | 1986-04-15 |
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| EXPY | Cancellation because of completion of term |