JPS6461494A - Production of 5'-0-acyl-5-fluorouridine derivative - Google Patents

Production of 5'-0-acyl-5-fluorouridine derivative

Info

Publication number
JPS6461494A
JPS6461494A JP62216147A JP21614787A JPS6461494A JP S6461494 A JPS6461494 A JP S6461494A JP 62216147 A JP62216147 A JP 62216147A JP 21614787 A JP21614787 A JP 21614787A JP S6461494 A JPS6461494 A JP S6461494A
Authority
JP
Japan
Prior art keywords
fluorouridine
derivative
amino acid
group
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62216147A
Other languages
Japanese (ja)
Inventor
Kunio Sanada
Yoshitaka Inamoto
Takeshi Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fuji Chemical Industries Co Ltd
Original Assignee
Fuji Chemical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Chemical Industries Co Ltd filed Critical Fuji Chemical Industries Co Ltd
Priority to JP62216147A priority Critical patent/JPS6461494A/en
Publication of JPS6461494A publication Critical patent/JPS6461494A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

PURPOSE:To obtain the titled derivative useful as an agent for alleviating malignant tumors, an antiviral agent and an intermediate thereof, by esterifying a specific fluorouridine derivative with an amino acid and eliminating the protecting group. CONSTITUTION:(A) A 5'-deoxy-5'-halo-5-fluorouridine having protected saccharide part is esterified with (B) an N-substituted amino acid, then the protecting group of the saccharide part is eliminated and optionally the amino acid-N- substituent group is eliminated to give the aimed derivative [e.g. 5'-0-(N- benzyloxycarbonylvalyl)-5-fluorouridine] shown by the formula (A is N- substituted-aminoacyl group or aminoacyl group).
JP62216147A 1987-08-28 1987-08-28 Production of 5'-0-acyl-5-fluorouridine derivative Pending JPS6461494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62216147A JPS6461494A (en) 1987-08-28 1987-08-28 Production of 5'-0-acyl-5-fluorouridine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62216147A JPS6461494A (en) 1987-08-28 1987-08-28 Production of 5'-0-acyl-5-fluorouridine derivative

Publications (1)

Publication Number Publication Date
JPS6461494A true JPS6461494A (en) 1989-03-08

Family

ID=16684016

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62216147A Pending JPS6461494A (en) 1987-08-28 1987-08-28 Production of 5'-0-acyl-5-fluorouridine derivative

Country Status (1)

Country Link
JP (1) JPS6461494A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012259A1 (en) * 1990-02-08 1991-08-22 Sankyo Company, Limited 5-fu derivative
US5783689A (en) * 1996-11-12 1998-07-21 University Of Notre Dame Antibacterial and antifungal nucleosides
US5808049A (en) * 1994-05-20 1998-09-15 Director-General Of Agency Of Industrial Science And Technology Stereospecific 5-fu esters and methods for preparing same

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991012259A1 (en) * 1990-02-08 1991-08-22 Sankyo Company, Limited 5-fu derivative
US5808049A (en) * 1994-05-20 1998-09-15 Director-General Of Agency Of Industrial Science And Technology Stereospecific 5-fu esters and methods for preparing same
US5783689A (en) * 1996-11-12 1998-07-21 University Of Notre Dame Antibacterial and antifungal nucleosides

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