JPS6463394A - Novel chimera polypeptide - Google Patents

Novel chimera polypeptide

Info

Publication number
JPS6463394A
JPS6463394A JP22175887A JP22175887A JPS6463394A JP S6463394 A JPS6463394 A JP S6463394A JP 22175887 A JP22175887 A JP 22175887A JP 22175887 A JP22175887 A JP 22175887A JP S6463394 A JPS6463394 A JP S6463394A
Authority
JP
Japan
Prior art keywords
immunoglobulin
cell
chimera polypeptide
variable region
mammal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP22175887A
Other languages
Japanese (ja)
Inventor
Yoshihisa Kuwana
Yoshikazu Kurosawa
Seiga Itou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujita Health University
KH Neochem Co Ltd
Original Assignee
Fujita Health University
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujita Health University, Kyowa Hakko Kogyo Co Ltd filed Critical Fujita Health University
Priority to JP22175887A priority Critical patent/JPS6463394A/en
Publication of JPS6463394A publication Critical patent/JPS6463394A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE:To produce the above-mentioned chimera polypeptide, by synthesize a recombinant wherein DNA coding chimera polypeptide containing variable region of mammal immunoglobulin and constant region of mammal T cell receptor are integrated. CONSTITUTION:A chimera polypeptide consisting of a variable region or immunoglobulin of mammal animal is produced in T cell by a recombinant technique. In the chimera polypeptide, variable region of mammal animal immunoglobulin is heavy chain variable region of mouse T15 immunoglobulin or light chain variable region of mouse S107 immunoglobulin and constant region of mammal animal T cell receptor comes preferably from chain constant region of mouse T cell. Antitumor activity is provided to a cell by integrating the chimera polypeptide into the T cell.
JP22175887A 1987-09-04 1987-09-04 Novel chimera polypeptide Pending JPS6463394A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22175887A JPS6463394A (en) 1987-09-04 1987-09-04 Novel chimera polypeptide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22175887A JPS6463394A (en) 1987-09-04 1987-09-04 Novel chimera polypeptide

Publications (1)

Publication Number Publication Date
JPS6463394A true JPS6463394A (en) 1989-03-09

Family

ID=16771745

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22175887A Pending JPS6463394A (en) 1987-09-04 1987-09-04 Novel chimera polypeptide

Country Status (1)

Country Link
JP (1) JPS6463394A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996003883A1 (en) * 1994-08-02 1996-02-15 The General Hospital Corporation Cells bearing cd4 decoy receptors and related molecules and methods
US5843728A (en) * 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5851828A (en) * 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5906936A (en) * 1988-05-04 1999-05-25 Yeda Research And Development Co. Ltd. Endowing lymphocytes with antibody specificity
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US6004811A (en) * 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
JP2017529841A (en) * 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Chimeric antigen receptor

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906936A (en) * 1988-05-04 1999-05-25 Yeda Research And Development Co. Ltd. Endowing lymphocytes with antibody specificity
US5843728A (en) * 1991-03-07 1998-12-01 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US5851828A (en) * 1991-03-07 1998-12-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US5912170A (en) * 1991-03-07 1999-06-15 The General Hospital Corporation Redirection of cellular immunity by protein-tyrosine kinase chimeras
US6004811A (en) * 1991-03-07 1999-12-21 The Massachussetts General Hospital Redirection of cellular immunity by protein tyrosine kinase chimeras
US7049136B2 (en) 1991-03-07 2006-05-23 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
US7094599B2 (en) 1991-03-07 2006-08-22 The General Hospital Corporation Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells
US7320787B2 (en) 1991-03-07 2008-01-22 The General Hospital Corporation Redirection of cellular immunity by protein tyrosine kinase chimeras
WO1996003883A1 (en) * 1994-08-02 1996-02-15 The General Hospital Corporation Cells bearing cd4 decoy receptors and related molecules and methods
JP2017529841A (en) * 2014-09-19 2017-10-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Chimeric antigen receptor

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