JPS6466197A - 3'-substituted-triazole-2',3'-dideoxy-5-substituted pyrimidine nucleoside derivative - Google Patents

3'-substituted-triazole-2',3'-dideoxy-5-substituted pyrimidine nucleoside derivative

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Publication number
JPS6466197A
JPS6466197A JP22477987A JP22477987A JPS6466197A JP S6466197 A JPS6466197 A JP S6466197A JP 22477987 A JP22477987 A JP 22477987A JP 22477987 A JP22477987 A JP 22477987A JP S6466197 A JPS6466197 A JP S6466197A
Authority
JP
Japan
Prior art keywords
substituted
dideoxy
pyrimidine nucleoside
triazole
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP22477987A
Other languages
Japanese (ja)
Other versions
JP2587647B2 (en
Inventor
Kazuharu Noguchi
Junichi Yamashita
Sanji Yasumoto
Toru Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Priority to JP22477987A priority Critical patent/JP2587647B2/en
Publication of JPS6466197A publication Critical patent/JPS6466197A/en
Application granted granted Critical
Publication of JP2587647B2 publication Critical patent/JP2587647B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound of formula I (W is H, Br, I, methyl, trifluoromethyl; R<1>, R<2> are H, lower alkyl, lower alkoxycarbonyl). EXAMPLE:3'-(1-Triazolyl)-2',3'-dideoxyuridine. USE:Antitumor agent, or antiviral. PREPARATION:The reaction between 3'-azide-2',3'-dideoxy-5-substituted pyrimidine nucleoside of formula II and an acetylene derivative of the formula: R<1>-CidenticalC-R<2> is carried out usually at 50-150 deg.C, when needed, in a sealed tube, in some cases in a solvent.
JP22477987A 1987-09-07 1987-09-07 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives Expired - Lifetime JP2587647B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP22477987A JP2587647B2 (en) 1987-09-07 1987-09-07 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22477987A JP2587647B2 (en) 1987-09-07 1987-09-07 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives

Publications (2)

Publication Number Publication Date
JPS6466197A true JPS6466197A (en) 1989-03-13
JP2587647B2 JP2587647B2 (en) 1997-03-05

Family

ID=16819079

Family Applications (1)

Application Number Title Priority Date Filing Date
JP22477987A Expired - Lifetime JP2587647B2 (en) 1987-09-07 1987-09-07 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives

Country Status (1)

Country Link
JP (1) JP2587647B2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6914052B2 (en) 2001-03-15 2005-07-05 The Trustees Of Boston College Selective anti-viral nucleoside chain terminators
JP2016500101A (en) * 2014-02-12 2016-01-07 アダム ミツキエビツ ユニバーシティ Cytotoxic 2 ', 5'-dideoxy-5-fluorouridine derivatives, process for their production and use thereof
JP2016500100A (en) * 2014-02-12 2016-01-07 アダム ミツキエビツ ユニバーシティ 2 ', 3'-dideoxy-5-fluorouridine derivatives, their production process and their use

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6914052B2 (en) 2001-03-15 2005-07-05 The Trustees Of Boston College Selective anti-viral nucleoside chain terminators
JP2016500101A (en) * 2014-02-12 2016-01-07 アダム ミツキエビツ ユニバーシティ Cytotoxic 2 ', 5'-dideoxy-5-fluorouridine derivatives, process for their production and use thereof
JP2016500100A (en) * 2014-02-12 2016-01-07 アダム ミツキエビツ ユニバーシティ 2 ', 3'-dideoxy-5-fluorouridine derivatives, their production process and their use

Also Published As

Publication number Publication date
JP2587647B2 (en) 1997-03-05

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