JPS6468359A - Novel benzimidazole derivative, manufacture and remedy for central nervous system disease - Google Patents

Novel benzimidazole derivative, manufacture and remedy for central nervous system disease

Info

Publication number: JPS6468359A
Authority: JP; Japan
Prior art keywords: remedy; manufacture; nervous system; central nervous; system disease
Prior art date: 1987-08-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP63207486A

Other languages

English (en)

Other versions

JP2818170B2 (ja

Inventor

Shierukopufu Kurausu

Buahateru Herumuuto

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer Pharma AG

Original Assignee

Schering AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-25

Filing date

1988-08-23

Publication date

1989-03-14

1988-08-23 Application filed by Schering AG filed Critical Schering AG

1989-03-14 Publication of JPS6468359A publication Critical patent/JPS6468359A/ja

1998-10-30 Application granted granted Critical

1998-10-30 Publication of JP2818170B2 publication Critical patent/JP2818170B2/ja

2013-10-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
208000015114 central nervous system disease Diseases 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
IWPAPERMAWYYDD-UHFFFAOYSA-N 4-(2-aminoethyl)-1,3-dihydrobenzimidazol-2-one Chemical compound NCCC1=CC=CC2=C1NC(=O)N2 IWPAPERMAWYYDD-UHFFFAOYSA-N 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

JP63207486A 1987-08-25 1988-08-23 新規ベンズイミダゾール−誘導体及びその製法 Expired - Lifetime JP2818170B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3728695.1		1987-08-25
DE19873728695 DE3728695A1 (de)	1987-08-25	1987-08-25	Neue benzimidazol-derivate

Publications (2)

Publication Number	Publication Date
JPS6468359A true JPS6468359A (en)	1989-03-14
JP2818170B2 JP2818170B2 (ja)	1998-10-30

Family

ID=6334659

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP63207486A Expired - Lifetime JP2818170B2 (ja)	1987-08-25	1988-08-23	新規ベンズイミダゾール−誘導体及びその製法

Country Status (17)

Country	Link
US (1)	US4925854A (ja)
EP (1)	EP0304789B1 (ja)
JP (1)	JP2818170B2 (ja)
AT (1)	ATE86982T1 (ja)
AU (1)	AU615939B2 (ja)
CA (1)	CA1330440C (ja)
DD (1)	DD274215A5 (ja)
DE (2)	DE3728695A1 (ja)
DK (1)	DK169701B1 (ja)
ES (1)	ES2054752T3 (ja)
FI (1)	FI99013C (ja)
HU (1)	HU201746B (ja)
IE (1)	IE63283B1 (ja)
IL (1)	IL87561A (ja)
NO (1)	NO170852C (ja)
PT (1)	PT88326B (ja)
ZA (1)	ZA886336B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE914003A1 (en) *	1990-11-20	1992-05-20	Astra Pharma Prod	Biologically Active Amines
US5371102A (en) *	1992-03-11	1994-12-06	University Of Hawaii	Compositions and methods of inhibiting thyroid activity
PE27997A1 (es)	1994-04-29	1997-09-20	Lilly Co Eli	Antagonistas de receptores de taquicininas
US5565454A (en) *	1995-05-31	1996-10-15	Ergo Science, Incorporated	Method for preventing intervention-associated stenosis and other symptoms associated with stenosis of blood vessels following non-bypass, invasive interventions
TW356468B (en) *	1995-09-15	1999-04-21	Astra Pharma Prod	Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
GB9526511D0 (en) *	1995-12-23	1996-02-28	Astra Pharma Prod	Pharmaceutically active compounds
WO2004032861A2 (en) *	2002-10-11	2004-04-22	Bristol-Myers Squibb Company	Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
BR112014014629B1 (pt)	2011-12-16	2018-03-27	Colgate-Palmolive Company	Composição de higiene oral e método de limpeza dos dentes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3813409A (en) *	1972-07-31	1974-05-28	Squibb & Sons Inc	Benzimidazolinone compounds
DE3042481A1 (de) *	1980-11-11	1982-06-16	A. Nattermann & Cie GmbH, 5000 Köln	(omega)-(2-oxo-benzazolinyl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
US4367337A (en) *	1981-01-05	1983-01-04	The Sherwin-Williams Company	Process for conversion of benzimidazolones to benzotriazoles
WO1986001204A1 (en) *	1984-08-15	1986-02-27	Schering Aktiengesellschaft	New dopamine derivatives, process for their production, and their use as medicinal products
US4554287A (en) *	1984-09-12	1985-11-19	Smithkline Beckman Corporation	Antihypertensive 7-[2-(dialkylamino)ethyl]-4-hydroxy-1,3-benzimidazol-2-ones

1987
- 1987-08-25 DE DE19873728695 patent/DE3728695A1/de not_active Withdrawn
1988
- 1988-08-17 DE DE8888113339T patent/DE3879322D1/de not_active Expired - Lifetime
- 1988-08-17 EP EP88113339A patent/EP0304789B1/de not_active Expired - Lifetime
- 1988-08-17 ES ES88113339T patent/ES2054752T3/es not_active Expired - Lifetime
- 1988-08-17 AT AT88113339T patent/ATE86982T1/de active
- 1988-08-22 IE IE255288A patent/IE63283B1/en not_active IP Right Cessation
- 1988-08-23 JP JP63207486A patent/JP2818170B2/ja not_active Expired - Lifetime
- 1988-08-23 DD DD88319141A patent/DD274215A5/de not_active IP Right Cessation
- 1988-08-24 HU HU884447A patent/HU201746B/hu not_active IP Right Cessation
- 1988-08-24 NO NO883776A patent/NO170852C/no unknown
- 1988-08-24 PT PT88326A patent/PT88326B/pt not_active IP Right Cessation
- 1988-08-24 CA CA000575617A patent/CA1330440C/en not_active Expired - Fee Related
- 1988-08-25 FI FI883930A patent/FI99013C/fi not_active IP Right Cessation
- 1988-08-25 US US07/236,383 patent/US4925854A/en not_active Expired - Fee Related
- 1988-08-25 ZA ZA886336A patent/ZA886336B/xx unknown
- 1988-08-25 IL IL87561A patent/IL87561A/xx not_active IP Right Cessation
- 1988-08-25 AU AU21498/88A patent/AU615939B2/en not_active Ceased
- 1988-08-25 DK DK474288A patent/DK169701B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA886336B (en)	1989-04-26
NO170852C (no)	1992-12-16
ATE86982T1 (de)	1993-04-15
EP0304789A3 (en)	1989-10-04
AU2149888A (en)	1989-03-02
DK169701B1 (da)	1995-01-16
DE3728695A1 (de)	1989-03-09
FI99013C (fi)	1997-09-25
PT88326A (pt)	1989-06-30
EP0304789B1 (de)	1993-03-17
IL87561A (en)	1993-02-21
HUT49589A (en)	1989-10-30
IL87561A0 (en)	1989-01-31
US4925854A (en)	1990-05-15
IE882552L (en)	1989-02-25
EP0304789A2 (de)	1989-03-01
DE3879322D1 (de)	1993-04-22
NO883776D0 (no)	1988-08-24
AU615939B2 (en)	1991-10-17
JP2818170B2 (ja)	1998-10-30
DK474288D0 (da)	1988-08-25
HU201746B (en)	1990-12-28
IE63283B1 (en)	1995-04-05
NO170852B (no)	1992-09-07
DD274215A5 (de)	1989-12-13
ES2054752T3 (es)	1994-08-16
FI99013B (fi)	1997-06-13
FI883930A0 (fi)	1988-08-25
NO883776L (no)	1989-02-27
DK474288A (da)	1989-02-26
FI883930L (fi)	1989-02-26
CA1330440C (en)	1994-06-28
PT88326B (pt)	1995-03-31

Publication	Publication Date	Title
ATE83659T1 (de)	1993-01-15	Verwendung von indolon-derivaten zur herstellung von arzneimitteln zur behandlung des parkinsonismus.
BG47033A3 (en)	1990-04-16	Method for preparing of derivatives of imidazolamine
ES2041705T3 (es)	1993-12-01	Procedimiento para la preparacion de 1-(4-hidroxi-3,5-di-terc-butil-benzoil)-homopiperazina y sus derivados.
JPS6468359A (en)	1989-03-14	Novel benzimidazole derivative, manufacture and remedy for central nervous system disease
TR199700206A2 (xx)	1997-10-21	Floralkil- ve floralkoksi ikame edilmi� heterosiklik bradikinin-antagonistleri, bunlar�n imal edilmesine mahsus usul ve bunlar�n kullan�lmalar�.
CS135189A2 (en)	1990-08-14	Method of 1-acyl-3-/4-/2-pyrimidinyl/-1-piperazinyl/propanes production
SE8704979D0 (sv)	1987-12-14	New furanuronic acid derivatives, process for their production and their use
PT92234A (pt)	1990-05-31	Processo para a preparacao de 1,2,3,4-tetraidro-1,9-acridinodiaminas
NO864635L (no)	1987-06-15	Nye krystallinske salter av aryloksypropanolaminer, deres fremstilling og anvendelse.
ATE121388T1 (de)	1995-05-15	3- oder 4-substituierte oxotremorin-derivate.
IT1225483B (it)	1990-11-14	Protesi ortopedica, particolarmente per la testa del femore.
PT88242A (pt)	1989-06-30	Processo para a preparacao de eteres e tioeteres tendo actividade terapeutica
FR2353531A2 (fr)	1977-12-30	Nouveaux derives de l'indoline, leur preparation et leur application comme medicaments
CS553488A2 (en)	1989-04-14	Method of new substituted 2-phenyl-7h-thiazolo (3,2-b) (1,2,4)triazine-7-ons production