JPS6470437A - Novel secoprostaglandins - Google Patents
Novel secoprostaglandinsInfo
- Publication number
- JPS6470437A JPS6470437A JP63202737A JP20273788A JPS6470437A JP S6470437 A JPS6470437 A JP S6470437A JP 63202737 A JP63202737 A JP 63202737A JP 20273788 A JP20273788 A JP 20273788A JP S6470437 A JPS6470437 A JP S6470437A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- oxo
- compound
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000000748 cardiovascular system Anatomy 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 210000004994 reproductive system Anatomy 0.000 abstract 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I (A is O; B is double bond of formula II; Y is 1-10C univalent hydrocarbon group; R is H, 1-6C alkyl or pharmaceutically permissible cation; Z is H, trimethylsilyl, t-butyldimethylsilyl or tetrahydropyranyl). EXAMPLE:9-Oxo-14 (S)-t-butyldimethylsilyloxynonadeca-5-cis-12-transdienoic acid methyl ester. USE:A drug. It is expected to be applicable to cardiovascular system, kidney, digestive tracts and genital system, to suppress lipid metabolism, inflammation, blood coagulation, blood platelet, dermatopathy and certain kind of cancer and to control immunity function. PREPARATION:A compound of formula I wherein A is oxo, Z is protecting group and R is 1-6C alkyl can be produced by alkylating ketones of formula III (Z' is protecting group) with a halide of formula IV (X is halogen; R' is 1-6C alkyl) at -78-+40 deg.C for 10min-3hr.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63202737A JPS6470437A (en) | 1988-08-16 | 1988-08-16 | Novel secoprostaglandins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63202737A JPS6470437A (en) | 1988-08-16 | 1988-08-16 | Novel secoprostaglandins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6470437A true JPS6470437A (en) | 1989-03-15 |
| JPH046696B2 JPH046696B2 (en) | 1992-02-06 |
Family
ID=16462330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63202737A Granted JPS6470437A (en) | 1988-08-16 | 1988-08-16 | Novel secoprostaglandins |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6470437A (en) |
-
1988
- 1988-08-16 JP JP63202737A patent/JPS6470437A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPH046696B2 (en) | 1992-02-06 |
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