JPS6474A - Benzimidazole derivative - Google Patents

Benzimidazole derivative

Info

Publication number
JPS6474A
JPS6474A JP3859687A JP3859687A JPS6474A JP S6474 A JPS6474 A JP S6474A JP 3859687 A JP3859687 A JP 3859687A JP 3859687 A JP3859687 A JP 3859687A JP S6474 A JPS6474 A JP S6474A
Authority
JP
Japan
Prior art keywords
formula
alkyl
compound expressed
agent
hydroxyalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3859687A
Other languages
Japanese (ja)
Other versions
JPH0174A (en
JPH054386B2 (en
Inventor
Kiyoto Goto
Kinji Hashimoto
Kenichi Kanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Factory Inc
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Priority to JP3859687A priority Critical patent/JPS6474A/en
Publication of JPH0174A publication Critical patent/JPH0174A/en
Publication of JPS6474A publication Critical patent/JPS6474A/en
Publication of JPH054386B2 publication Critical patent/JPH054386B2/ja
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound expressed by formula I [R1 is alkyl, hydroxyalkyl, alkoxycarbonylalkyl, carboxylalkyl, (alkylsubstituted)phenyl, amino, alkylamino or alkoxycarbonylamino; R2 are R3 are alkyl] and salt thereof.
EXAMPLE: 1-(3,5-di-tert.-Butyl-4-hydroxyphenyl)-2-(2-methoxycarbonylethyl)benzi midazole.
USE: Useful as an antiphlogistics, antiallergic agent, antirheumatics, analgesic, diuretic, antithrombic agent, hypotensive agent, etc.
PREPARATION: A 1,4-benzoquinone derivative expressed by formula II is con densed with o-phenylenediamine to afford a compound expressed by formula III, which is then reduced and condensed with the formula R1a-COOH (R1a is alkyl or hydroxyalkyl) to provide the aimed compound expressed by formula I.
COPYRIGHT: (C)1989,JPO&Japio
JP3859687A 1987-01-29 1987-02-20 Benzimidazole derivative Granted JPS6474A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3859687A JPS6474A (en) 1987-01-29 1987-02-20 Benzimidazole derivative

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1975787 1987-01-29
JP3859687A JPS6474A (en) 1987-01-29 1987-02-20 Benzimidazole derivative
JP62-19757 1987-05-20

Publications (3)

Publication Number Publication Date
JPH0174A JPH0174A (en) 1989-01-05
JPS6474A true JPS6474A (en) 1989-01-05
JPH054386B2 JPH054386B2 (en) 1993-01-19

Family

ID=26356609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3859687A Granted JPS6474A (en) 1987-01-29 1987-02-20 Benzimidazole derivative

Country Status (1)

Country Link
JP (1) JPS6474A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993007124A1 (en) * 1991-09-30 1993-04-15 Eisai Co., Ltd. Nitrogenous heterocyclic compound
EP0520200A3 (en) * 1991-06-24 1993-05-12 Neurosearch A/S Imidazole compounds, their preparation and use
WO2004000817A3 (en) * 2002-06-24 2004-05-21 Pfizer Prod Inc Benzimidazole compounds and their use as estrogen agonists/antagonists
JP2008303211A (en) * 2003-03-13 2008-12-18 Idemitsu Kosan Co Ltd Novel nitrogen-containing heterocyclic derivative and organic electroluminescence device using the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520200A3 (en) * 1991-06-24 1993-05-12 Neurosearch A/S Imidazole compounds, their preparation and use
AU653816B2 (en) * 1991-06-24 1994-10-13 Neurosearch A/S Imidazole compounds, their preparation and use
WO1993007124A1 (en) * 1991-09-30 1993-04-15 Eisai Co., Ltd. Nitrogenous heterocyclic compound
WO2004000817A3 (en) * 2002-06-24 2004-05-21 Pfizer Prod Inc Benzimidazole compounds and their use as estrogen agonists/antagonists
JP2008303211A (en) * 2003-03-13 2008-12-18 Idemitsu Kosan Co Ltd Novel nitrogen-containing heterocyclic derivative and organic electroluminescence device using the same

Also Published As

Publication number Publication date
JPH054386B2 (en) 1993-01-19

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees