JPS6475433A - Remedy for herpes simplex virus infection - Google Patents
Remedy for herpes simplex virus infectionInfo
- Publication number
- JPS6475433A JPS6475433A JP22987087A JP22987087A JPS6475433A JP S6475433 A JPS6475433 A JP S6475433A JP 22987087 A JP22987087 A JP 22987087A JP 22987087 A JP22987087 A JP 22987087A JP S6475433 A JPS6475433 A JP S6475433A
- Authority
- JP
- Japan
- Prior art keywords
- acyclovir
- monoclonal antibody
- remedy
- herpes simplex
- simplex virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000009889 Herpes Simplex Diseases 0.000 title 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 abstract 4
- 229960004150 aciclovir Drugs 0.000 abstract 4
- 102000003886 Glycoproteins Human genes 0.000 abstract 2
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 241000700584 Simplexvirus Species 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 102000008100 Human Serum Albumin Human genes 0.000 abstract 1
- 108091006905 Human Serum Albumin Proteins 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000011812 mixed powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940124272 protein stabilizer Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 229910000162 sodium phosphate Inorganic materials 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PURPOSE:To obtain the title remedy which is also effective against resistant strains and has a low toxicity, by using IgG human monoclonal antibody reacting with the glycoprotein of herpes simplex virus and acyclovir as active ingredients. CONSTITUTION:The title remedy includes, as active ingredients, an IgG human monoclonal antibody of about 160,000mol.wt. which reacts with the glycoprotein B in herpes simplex virus I or II, and acyclovir of the formula. The forms of the preparation are, for example, a mixed powder for injection, a combination kit of separately prepared monoclonal antibody and acyclovir, in which the content of the monoclonal antibody is 1-10mg/ml, while acyclovir, 10-1,000mg. The salts to be added to the solution for dissolution are 0.9w/v% of NaCl, 0.02M of sodium phosphate, and human serum albumin is added as a protein stabilizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22987087A JPS6475433A (en) | 1987-09-16 | 1987-09-16 | Remedy for herpes simplex virus infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP22987087A JPS6475433A (en) | 1987-09-16 | 1987-09-16 | Remedy for herpes simplex virus infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6475433A true JPS6475433A (en) | 1989-03-22 |
Family
ID=16898994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22987087A Pending JPS6475433A (en) | 1987-09-16 | 1987-09-16 | Remedy for herpes simplex virus infection |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6475433A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022136A2 (en) | 1996-11-19 | 1998-05-28 | Roche Diagnostics Gmbh | Stable lyophilized pharmaceutical substances from monoclonal or polyclonal antibodies |
| KR20130010466A (en) * | 2010-03-22 | 2013-01-28 | 제넨테크, 인크. | Compositions and methods useful for stabilizing protein-containing formulations |
-
1987
- 1987-09-16 JP JP22987087A patent/JPS6475433A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998022136A2 (en) | 1996-11-19 | 1998-05-28 | Roche Diagnostics Gmbh | Stable lyophilized pharmaceutical substances from monoclonal or polyclonal antibodies |
| EP0852951A1 (en) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stable lyophilized monoclonal or polyclonal antibodies containing pharmaceuticals |
| KR20130010466A (en) * | 2010-03-22 | 2013-01-28 | 제넨테크, 인크. | Compositions and methods useful for stabilizing protein-containing formulations |
| JP2013527832A (en) * | 2010-03-22 | 2013-07-04 | ジェネンテック， インコーポレイテッド | Compositions and methods useful for stabilizing protein-containing formulations |
| JP2016193909A (en) * | 2010-03-22 | 2016-11-17 | ジェネンテック， インコーポレイテッド | Compositions and methods useful for stabilizing protein-containing formulations |
| US9662395B2 (en) | 2010-03-22 | 2017-05-30 | Genentech, Inc. | Compositions and methods useful for stabilizing protein-containing formulations |
| KR101878369B1 (en) * | 2010-03-22 | 2018-07-16 | 제넨테크, 인크. | Compositions and methods useful for stabilizing protein-containing formulations |
| KR20190104254A (en) * | 2010-03-22 | 2019-09-06 | 제넨테크, 인크. | Compositions and methods useful for stabilizing protein-containing formulations |
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