JPS6479190A - Production of gamma-substituted-alpha-siloxy-butenolide derivative - Google Patents

Production of gamma-substituted-alpha-siloxy-butenolide derivative

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Publication number
JPS6479190A
JPS6479190A JP23787087A JP23787087A JPS6479190A JP S6479190 A JPS6479190 A JP S6479190A JP 23787087 A JP23787087 A JP 23787087A JP 23787087 A JP23787087 A JP 23787087A JP S6479190 A JPS6479190 A JP S6479190A
Authority
JP
Japan
Prior art keywords
alpha
acid
gamma
trialkylsiloxy
aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP23787087A
Other languages
Japanese (ja)
Inventor
Hideyuki Sugimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noguchi Institute
Original Assignee
Noguchi Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noguchi Institute filed Critical Noguchi Institute
Priority to JP23787087A priority Critical patent/JPS6479190A/en
Publication of JPS6479190A publication Critical patent/JPS6479190A/en
Pending legal-status Critical Current

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Abstract

PURPOSE:To obtain the titled compound useful as a synthetic intermediate for sialic acid, etc., from readily available raw materials by a simple method, by carrying out reaction in specific three steps using a (trialkylsiloxy)acrylic acid and aldehyde as starting raw materials. CONSTITUTION:An aldehyde and 2-(trialkylsiloxy)acrylic acid ester are initially reacted in the presence of a Lewis acid, preferably using dichloromethane as a solvent, normally at 0 deg.C and the resultant gamma-hydroxy-alpha-keto ester is lactonized in the presence of an acid catalyst (e.g., hydrochloric acid), normally at ambient temperature to afford an alpha-hydroxy-butenolide derivative, which is then preferably silylated with a tert-butyldimethylchlorosilane-imidazole based silylating agent to provide the aimed compound.
JP23787087A 1987-09-22 1987-09-22 Production of gamma-substituted-alpha-siloxy-butenolide derivative Pending JPS6479190A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP23787087A JPS6479190A (en) 1987-09-22 1987-09-22 Production of gamma-substituted-alpha-siloxy-butenolide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23787087A JPS6479190A (en) 1987-09-22 1987-09-22 Production of gamma-substituted-alpha-siloxy-butenolide derivative

Publications (1)

Publication Number Publication Date
JPS6479190A true JPS6479190A (en) 1989-03-24

Family

ID=17021636

Family Applications (1)

Application Number Title Priority Date Filing Date
JP23787087A Pending JPS6479190A (en) 1987-09-22 1987-09-22 Production of gamma-substituted-alpha-siloxy-butenolide derivative

Country Status (1)

Country Link
JP (1) JPS6479190A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017165845A (en) * 2016-03-15 2017-09-21 株式会社日本触媒 Method for producing lactone ring-containing polymer, polymer and lactone ring-containing polymer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017165845A (en) * 2016-03-15 2017-09-21 株式会社日本触媒 Method for producing lactone ring-containing polymer, polymer and lactone ring-containing polymer

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