JPS6483092A - Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component - Google Patents
Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active componentInfo
- Publication number
- JPS6483092A JPS6483092A JP23925587A JP23925587A JPS6483092A JP S6483092 A JPS6483092 A JP S6483092A JP 23925587 A JP23925587 A JP 23925587A JP 23925587 A JP23925587 A JP 23925587A JP S6483092 A JPS6483092 A JP S6483092A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- carcinostatic
- dimethyladenosine
- novel
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003327 cancerostatic effect Effects 0.000 title abstract 3
- WVGPGNPCZPYCLK-WOUKDFQISA-N N(6),N(6)-dimethyladenosine Chemical class C1=NC=2C(N(C)C)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O WVGPGNPCZPYCLK-WOUKDFQISA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 abstract 2
- MUZIZEZCKKMZRT-UHFFFAOYSA-N 1,2-dithiolane Chemical group C1CSSC1 MUZIZEZCKKMZRT-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- -1 carboxylic acid halides Chemical class 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The N<6>,N<6>-dimethyladenosine sugar ester derivative of formula I (R is >=4C alkyl >=2C halogenated alkyl, >=4C alkyl having 1,2-dithiolane ring at the terminal, >=4C alkenyl or alkynyl) or its isopropylidene derivative at 2,3-sites of the sugar part. USE:A carcinostatic agent. PREPARATION:2',3'-0-isopropylidene-N<6>,N<6>-dimethyladenosine of formula II is made to react with carboxylic acids or carboxylic acid halides of formula III (X is OH or halogen) and, as necessary, removing the isopropylidene group by acid hydrolysis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23925587A JPS6483092A (en) | 1987-09-24 | 1987-09-24 | Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23925587A JPS6483092A (en) | 1987-09-24 | 1987-09-24 | Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6483092A true JPS6483092A (en) | 1989-03-28 |
Family
ID=17042041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP23925587A Pending JPS6483092A (en) | 1987-09-24 | 1987-09-24 | Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6483092A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06511249A (en) * | 1991-10-07 | 1994-12-15 | ノルスク・ヒドロ・アーエスアー | Compound |
| US5958309A (en) * | 1996-03-06 | 1999-09-28 | Idemitsu Petrochemical Co., Ltd. | Method for manufacturing thermoplastic sheets bearing embossed patterns thereon and an apparatus therefor |
| US6153594A (en) * | 1993-04-05 | 2000-11-28 | Norsk Hydro As | 5'-O-acylated antiviral nucleosides |
| USRE38495E1 (en) * | 1996-03-06 | 2004-04-13 | Idemitsu Petrochemical Co., Ltd. | Method for manufacturing thermoplastic sheets bearing embossed patterns thereon and an apparatus therefor |
| EP2711008A1 (en) | 2012-09-19 | 2014-03-26 | Institut Univ. de Ciència i Tecnologia, S.A. | N6,N6-dimethyladenosine for use in treating or preventing primary and metastatic breast cancer |
-
1987
- 1987-09-24 JP JP23925587A patent/JPS6483092A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06511249A (en) * | 1991-10-07 | 1994-12-15 | ノルスク・ヒドロ・アーエスアー | Compound |
| US6548486B1 (en) | 1991-10-07 | 2003-04-15 | Norsk Hydro A.S. | Fatty acid esters of nucleoside analogs |
| US6153594A (en) * | 1993-04-05 | 2000-11-28 | Norsk Hydro As | 5'-O-acylated antiviral nucleosides |
| US5958309A (en) * | 1996-03-06 | 1999-09-28 | Idemitsu Petrochemical Co., Ltd. | Method for manufacturing thermoplastic sheets bearing embossed patterns thereon and an apparatus therefor |
| USRE38495E1 (en) * | 1996-03-06 | 2004-04-13 | Idemitsu Petrochemical Co., Ltd. | Method for manufacturing thermoplastic sheets bearing embossed patterns thereon and an apparatus therefor |
| EP2711008A1 (en) | 2012-09-19 | 2014-03-26 | Institut Univ. de Ciència i Tecnologia, S.A. | N6,N6-dimethyladenosine for use in treating or preventing primary and metastatic breast cancer |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IE873288L (en) | Derivatives of bicyclic aminocarboxylic acids. | |
| IL66151A (en) | Preparation of optically pure d-or l-lactic acid by fermentation | |
| JPS6483092A (en) | Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component | |
| ES8101610A1 (en) | 7-Methoxy-5-oxo-5H-thiazolo(2,3-b)quinazolin-2-carboxylic acid and its pharmaceutically acceptable salts, process for their preparation and medicines containing them. | |
| PT84597A (en) | Process for the preparation of compositions for increasing crop yield containing malonic acid derivatives as well as of novel malonic acid derivatives | |
| EP0103320A3 (en) | Acetylsalicylic acid thioesters, a process for their preparation and pharmaceutical compositions containing them | |
| ES8600751A1 (en) | Oxazoleacetic acid derivatives, process for their production and compositions containing said derivatives. | |
| IE45178L (en) | Phenothiazine derivatives | |
| ES8101592A1 (en) | Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates. | |
| IE832787L (en) | Polyether compounds. | |
| GB1530872A (en) | Derivatives of 7-(2-amino-4-thiazolylacetamido)-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them | |
| JPS559060A (en) | Thia(oxa)zolidinecarboxylic acid derivative and its prepatation | |
| JPS5553291A (en) | Naphthylidine derivative and its preparation | |
| UA5590A1 (en) | Process for preparation of propileneglycol ester of substituted 1,4-dihydropyridyl-5-phosphonic acid, or pharmaceutically acceptable salt or solvate thereof | |
| JPS5414983A (en) | Tunicamine derivative and its preparation | |
| JPS53108983A (en) | Preparation of 5-fluorouracil | |
| JPS55145669A (en) | 8,10-diazaprostanoic acid derivative and its preparation | |
| JPS5653678A (en) | Preparation of 1,10-phenanthroilnes | |
| JPS5321170A (en) | Preparation of branched 2-deoxy-alpha-glycosides | |
| JPS5459270A (en) | (n-alkylpyrryl-2)acetthioamide derivative and its preparation | |
| ES8502429A1 (en) | Bronchial secretion promotive, mucus fluidization active and antitussive novel compound, manufacture and pharmaceutical composition | |
| JPS54122281A (en) | 5-fluorouracil derivative and its preparation | |
| JPS56125339A (en) | Preparation of phenylacetic acid derivative | |
| JPS5573690A (en) | Novel penicillin derivative and antibacterial comprising it | |
| IE45365L (en) | N-(6-CHLORONICOTINOYL)-d,l-HOMOCYSTEINE THIOLACTONE |