JPS6485272A - Adhesive - Google Patents
AdhesiveInfo
- Publication number
- JPS6485272A JPS6485272A JP62311418A JP31141887A JPS6485272A JP S6485272 A JPS6485272 A JP S6485272A JP 62311418 A JP62311418 A JP 62311418A JP 31141887 A JP31141887 A JP 31141887A JP S6485272 A JPS6485272 A JP S6485272A
- Authority
- JP
- Japan
- Prior art keywords
- component
- solution
- dissolved
- silk fibroin
- metal salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000853 adhesive Substances 0.000 title abstract 2
- 230000001070 adhesive effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 108010022355 Fibroins Proteins 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229940106780 human fibrinogen Drugs 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 108010013296 Sericins Proteins 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 239000012153 distilled water Substances 0.000 abstract 1
- 239000012510 hollow fiber Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Materials For Medical Uses (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
PURPOSE:To obtain an adhesive excellent in biocompatibility and adhesiveness and useful for surgical operation, by mixing human fibrinogen with silk fibroin. CONSTITUTION:Silk fibroin (B) which has optionally been freed from sericin and treated with an enzyme is dissolved in 2-50pts.wt., per pt.wt. (B), 5-80wt.% aqueous solution of an alkali (alkaline earth) metal salt, and said metal salt is removed from the solution with a dialyzer in which a dialyzing membrane or a hollow fiber is used. A salt is optionally added to the dialyzate to obtain an aqueous solution of component B. Human fibrinogen (A) is dissolved in distilled water at 32-35 deg.C, and the resulting solution is mixed with an aqueous component B solution containing 5-90wt.%, preferably, 20-70wt.%, based on the mixture of components A and B, component B.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62311418A JPS6485272A (en) | 1986-12-10 | 1987-12-09 | Adhesive |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29414886 | 1986-12-10 | ||
| JP62311418A JPS6485272A (en) | 1986-12-10 | 1987-12-09 | Adhesive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6485272A true JPS6485272A (en) | 1989-03-30 |
Family
ID=26559695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62311418A Pending JPS6485272A (en) | 1986-12-10 | 1987-12-09 | Adhesive |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6485272A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06507376A (en) * | 1990-07-27 | 1994-08-25 | バース、ローレンス・サミュエル | Tissue joining and sealing compositions and methods of use thereof |
| JP2010511426A (en) * | 2006-12-04 | 2010-04-15 | アボット、カーディオバスキュラー、システムズ、インコーポレーテッド | Tissue treatment method and composition using silk protein |
| JP2010259767A (en) * | 2009-05-08 | 2010-11-18 | Industry Academic Cooperation Foundation Hallym Univ | Artificial eardrum using silk protein and method for producing the same |
| JP2013536737A (en) * | 2010-09-01 | 2013-09-26 | トラスティーズ・オブ・タフツ・カレッジ | Biomaterials based on silk fibroin and polyethylene glycol |
-
1987
- 1987-12-09 JP JP62311418A patent/JPS6485272A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06507376A (en) * | 1990-07-27 | 1994-08-25 | バース、ローレンス・サミュエル | Tissue joining and sealing compositions and methods of use thereof |
| JP2010511426A (en) * | 2006-12-04 | 2010-04-15 | アボット、カーディオバスキュラー、システムズ、インコーポレーテッド | Tissue treatment method and composition using silk protein |
| JP2010259767A (en) * | 2009-05-08 | 2010-11-18 | Industry Academic Cooperation Foundation Hallym Univ | Artificial eardrum using silk protein and method for producing the same |
| JP2013536737A (en) * | 2010-09-01 | 2013-09-26 | トラスティーズ・オブ・タフツ・カレッジ | Biomaterials based on silk fibroin and polyethylene glycol |
| US9566365B2 (en) | 2010-09-01 | 2017-02-14 | Trustees Of Tufts College | Silk fibroin and polyethylene glycol-based biomaterials |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2059456T3 (en) | PROCEDURE TO MANUFACTURE AND USE USEFUL POLYAMID MEMBRANES TO SOFTEN WATER. | |
| DE60035016D1 (en) | Active oxygen containing solution for promoting tissue growth at wound sites | |
| DK0777768T3 (en) | Cellulose solutions and products made therefrom | |
| DE69939871D1 (en) | DEVICE AND METHOD FOR PRODUCING STABLE LIME THROMBIN FROM PLASMA AND THROMBIN MADE THEREOF | |
| CA2236262A1 (en) | Room temperature sterilant for medical devices | |
| DE69419324D1 (en) | METHOD FOR PRODUCING A BIOLOGICAL ADHESIVE CONTAINING FIBRINOGEN, FACTOR XIII AND FIBRONECTIN | |
| DE59210000D1 (en) | Process for the preparation of a stable fibrinogen solution | |
| ES8600613A1 (en) | Body implants of extracellular matrix and means and methods of making and using such implants. | |
| ATE218365T1 (en) | STABILIZED FIBRINOGEN-BASED MIXTURE | |
| CA2113663A1 (en) | Process for the obtention of a biological adhesive made of concentrated coagulation factors by acidic precipitation | |
| DE19748290B8 (en) | Solution for peritoneal dialysis | |
| DE3783282D1 (en) | VARIANTS OF LAV VIRUSES, THEIR DNA AND PROTEIN COMPONENTS AND THEIR USE, IN PARTICULAR FOR DIAGNOSTIC PURPOSES AND FOR THE PRODUCTION OF IMMUNOGENOUS COMPOSITIONS. | |
| DE69017453D1 (en) | ARTIFICIAL BIOLOGICAL MEMBRANE. | |
| ATE245629T1 (en) | CRYSTALLIZATION OF LEVOBUPIVACAINE AND THEIR ANALOGUES | |
| UA29462C2 (en) | cellulose-acetate semi-permeable membrane in form of hollow fiber (variants), method for production of hollow fiber cellulose-acetate semi-permeable membrane (variants), hemodialyzer with cellulose-acetate semi-permeable membranes, device for treatment | |
| YU55891A (en) | PROCEDURE FOR SEPARATION OF WATER FROM DILUTED AQUEOUS SOLUTION OF N-METHYLFORMOLIN-N-OXIDE, N-METHYLFORMOLIN, MORPHOLINE OR MIXTURES THEREOF | |
| MX9206335A (en) | EX VIVO TISSUE DIFFUSION COMPOSITION FOR THE DIFFUSION OF TISSUES AND ORGANS. | |
| UA13377A (en) | Method for preparing antiviral composition | |
| ES2014438B3 (en) | DERIVATIVES OF THE ACID 2-PHOSPHONOBUTANE-1,2,4 TRICARBOXILICO, AS EMULSIVE AGENTS. | |
| DE59303997D1 (en) | FLUE GAS DESULFURATION | |
| DK135588A (en) | INACTIVATION OF HIV IN PROTEINAL SOLUTIONS USING PHENOLES | |
| JPS5361576A (en) | Preparation of sterilized dialyzer | |
| KR920006008A (en) | Preparation method of bone formation promoting substance | |
| ES2056657T3 (en) | DERIVED FROM BETA-PHENYLISOSERINE, ITS PREPARATION AND ITS USE. | |
| DE59805246D1 (en) | TISSUE FACTOR INFLUENCING VASOCULAR FORMATION |