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Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
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Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co LtdfiledCriticalDaiichi Pharmaceutical Co Ltd
Priority to JP63-25136ApriorityCriticalpatent/JPH0186A/en
Priority claimed from JP63-25136Aexternal-prioritypatent/JPH0186A/en
Publication of JPS6486ApublicationCriticalpatent/JPS6486A/en
Publication of JPH0186ApublicationCriticalpatent/JPH0186A/en
Publication of JPH059436B2publicationCriticalpatent/JPH059436B2/ja
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
NEW MATERIAL:A compound expressed by formula I {A represents identicalC-A' [A' represents H or (halogeno) lower alkyl] or identicalN-; R represents (halogeno) lower alkyl, (halogeno) alkenyl, (substituted) cycloalkyl or (substituted) cycloalkenyl; X represents single bond, (substituted) alkylene or (substituted) alkenylene} and salt thereof. EXAMPLE:6-(2-Cyclohexylethyl)-[1,3,4]thiadiazolo [3,2,a] [1,2,3]triazole [4,5- d]pyrimidin-3(1H)-one. USE:An antiallergic agent. PREPARATION:A compound (salt) expressed by formula II is added into an appropriate amount of an acidic solvent to form an acidic solution or acidic suspension, which is then reacted with a nitrite normally which being coold with ice - at ambient temperature for 30min - 1 day.
7-substituted-3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5,6-dihydro-5-methyl-6-oxo-4h-imidazo(1,5-a)-(1,4)-benzodiazepines,pharmaceutical compositions containing them and method of preparing them