JPS6494A - Novel organoplatinum complex - Google Patents

Novel organoplatinum complex

Info

Publication number
JPS6494A
JPS6494A JP63051178A JP5117888A JPS6494A JP S6494 A JPS6494 A JP S6494A JP 63051178 A JP63051178 A JP 63051178A JP 5117888 A JP5117888 A JP 5117888A JP S6494 A JPS6494 A JP S6494A
Authority
JP
Japan
Prior art keywords
formula
substituted
compound
amino
heteromonocyclic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63051178A
Other languages
Japanese (ja)
Other versions
JPH0194A (en
Inventor
Kenji Tsujihara
Osamu Otsuki
Tadashi Nakatani
Yoshihisa Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP63051178A priority Critical patent/JPS6494A/en
Publication of JPH0194A publication Critical patent/JPH0194A/en
Publication of JPS6494A publication Critical patent/JPS6494A/en
Pending legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [R1 is H or lower alkyl; R2 is H, (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy lower alkanoyl, amino, (substituted) nitrogen-containing heteromonocyclic group or oxygen-containing heteromonocyclic group; Alk is lower alkylene; X is carbonyl or sulfonyl; n is 1 or 2].
EXAMPLE: [2-[{N-(Chloroacetyl)glycyl}amino]malonato](trans-l-1-2-diaminocyclo hexane)platinum (II).
USE: An antitumor agent being preferably parenterally administered.
PREPARATION: A 1,2-diaminocyclohexane platinum complex shown by formula II (X1 and X2 are reactive residue ) is reacted with a 2-(substituted) aminomalonic acid (salt) shown by formula III. The compounds shown by formu la III is a novel substance and is obtained by reacting a compound shown by formula IV (h does not exceed n and is 0W2) with a compound by formula V.
COPYRIGHT: (C)1989,JPO&Japio
JP63051178A 1987-03-06 1988-03-03 Novel organoplatinum complex Pending JPS6494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63051178A JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-52823 1987-03-06
JP5282387 1987-03-06
JP63051178A JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Publications (2)

Publication Number Publication Date
JPH0194A JPH0194A (en) 1989-01-05
JPS6494A true JPS6494A (en) 1989-01-05

Family

ID=26391713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63051178A Pending JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Country Status (1)

Country Link
JP (1) JPS6494A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530317A (en) * 2000-01-04 2003-10-14 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidomalonate platinum complex
JP2007522244A (en) * 2004-02-13 2007-08-09 アクセス ファーマシューティカルズ， インコーポレイテッド O, O'-amidmalonate and N, O-amidmalonate platinum complexes
JP2023523039A (en) * 2020-04-22 2023-06-01 オンコヴォリューション エル・エル・シー Peptide platinum complexes and methods of use thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530317A (en) * 2000-01-04 2003-10-14 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidomalonate platinum complex
JP2011137046A (en) * 2000-01-04 2011-07-14 Access Pharmaceuticals Inc N, o-amidomalonate platinum complex
JP5025062B2 (en) * 2000-01-04 2012-09-12 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidmalonate platinum complex
JP2007522244A (en) * 2004-02-13 2007-08-09 アクセス ファーマシューティカルズ， インコーポレイテッド O, O'-amidmalonate and N, O-amidmalonate platinum complexes
JP2011105736A (en) * 2004-02-13 2011-06-02 Access Pharmaceuticals Inc O,o'-amidomalonate and n,o-amidomalonate platinum complex
JP2023523039A (en) * 2020-04-22 2023-06-01 オンコヴォリューション エル・エル・シー Peptide platinum complexes and methods of use thereof

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