JPS6494A - Novel organoplatinum complex - Google Patents

Novel organoplatinum complex

Info

Publication number
JPS6494A
JPS6494A JP63051178A JP5117888A JPS6494A JP S6494 A JPS6494 A JP S6494A JP 63051178 A JP63051178 A JP 63051178A JP 5117888 A JP5117888 A JP 5117888A JP S6494 A JPS6494 A JP S6494A
Authority
JP
Japan
Prior art keywords
formula
substituted
compound
amino
heteromonocyclic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP63051178A
Other languages
Japanese (ja)
Other versions
JPH0194A (en
Inventor
Kenji Tsujihara
Osamu Otsuki
Tadashi Nakatani
Yoshihisa Arai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP63051178A priority Critical patent/JPS6494A/en
Publication of JPH0194A publication Critical patent/JPH0194A/en
Publication of JPS6494A publication Critical patent/JPS6494A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [R1 is H or lower alkyl; R2 is H, (substituted) lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy lower alkanoyl, amino, (substituted) nitrogen-containing heteromonocyclic group or oxygen-containing heteromonocyclic group; Alk is lower alkylene; X is carbonyl or sulfonyl; n is 1 or 2].
EXAMPLE: [2-[{N-(Chloroacetyl)glycyl}amino]malonato](trans-l-1-2-diaminocyclo hexane)platinum (II).
USE: An antitumor agent being preferably parenterally administered.
PREPARATION: A 1,2-diaminocyclohexane platinum complex shown by formula II (X1 and X2 are reactive residue ) is reacted with a 2-(substituted) aminomalonic acid (salt) shown by formula III. The compounds shown by formu la III is a novel substance and is obtained by reacting a compound shown by formula IV (h does not exceed n and is 0W2) with a compound by formula V.
COPYRIGHT: (C)1989,JPO&Japio
JP63051178A 1987-03-06 1988-03-03 Novel organoplatinum complex Pending JPS6494A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63051178A JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-52823 1987-03-06
JP5282387 1987-03-06
JP63051178A JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Publications (2)

Publication Number Publication Date
JPH0194A JPH0194A (en) 1989-01-05
JPS6494A true JPS6494A (en) 1989-01-05

Family

ID=26391713

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63051178A Pending JPS6494A (en) 1987-03-06 1988-03-03 Novel organoplatinum complex

Country Status (1)

Country Link
JP (1) JPS6494A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530317A (en) * 2000-01-04 2003-10-14 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidomalonate platinum complex
JP2007522244A (en) * 2004-02-13 2007-08-09 アクセス ファーマシューティカルズ， インコーポレイテッド O, O'-amidmalonate and N, O-amidmalonate platinum complexes
JP2023523039A (en) * 2020-04-22 2023-06-01 オンコヴォリューション エル・エル・シー Peptide platinum complexes and methods of use thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003530317A (en) * 2000-01-04 2003-10-14 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidomalonate platinum complex
JP2011137046A (en) * 2000-01-04 2011-07-14 Access Pharmaceuticals Inc N, o-amidomalonate platinum complex
JP5025062B2 (en) * 2000-01-04 2012-09-12 アクセス ファーマシューティカルズ， インコーポレイテッド N, O-amidmalonate platinum complex
JP2007522244A (en) * 2004-02-13 2007-08-09 アクセス ファーマシューティカルズ， インコーポレイテッド O, O'-amidmalonate and N, O-amidmalonate platinum complexes
JP2011105736A (en) * 2004-02-13 2011-06-02 Access Pharmaceuticals Inc O,o'-amidomalonate and n,o-amidomalonate platinum complex
JP2023523039A (en) * 2020-04-22 2023-06-01 オンコヴォリューション エル・エル・シー Peptide platinum complexes and methods of use thereof

Similar Documents

Publication Publication Date Title
GR3001889T3 (en) Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
ZA793150B (en) 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphanes,processes for their preparation,and pharmaceutical compositions thereof
DE2964211D1 (en) Complexes of 9-hydroxyalkyl-purines, processes for preparing them and therapeutical compositions containing the complexes as active ingredients
DE3570437D1 (en) 1-hydroxy-1,1-diphosphonic-acid derivatives, process for their preparation and pharmaceutical preparations, especially for the treatment of bone tumours
EP0281412A3 (en) Novel organic platinum complex pharmaceutical compositions containing same and a process for the preparation thereof
JPS56103168A (en) Thiazole derivative, its preparation, and antihistaminic agent containing the same
JPS6494A (en) Novel organoplatinum complex
ES2045067T3 (en) PROCEDURE FOR PREPARING NEW TIAZOL COMPOUNDS.
GB1434323A (en) N-acylated substituted piperazine or homopiperazine derivatives and processes for their preparation
IL125926A0 (en) Compounds related to the amidinium family pharmaceutical compositions containing them and uses thereof
IL66789A (en) 6-amino-benzocyclo-pentane,-hexane,and-heptane derivatives,processes for their preparation and pharmaceutical preparations containing them
IL95762A0 (en) Benzanilides,their preparation and pharmaceutical compositions containing the same
JPS57163369A (en) Novel geldanamycin derivative, its preparation, and drug comprising it as active ingredient
JPS6413083A (en) Streptonigrin derivative and medicinal composition
JPS6493A (en) Novel organoplatinum complex
CA2134560A1 (en) Anti-obesity drugs
CA2335394A1 (en) Aerothricin analogs, their preparation and use
GB8515212D0 (en) Thiazolidine derivatives
MY105374A (en) A process for the preparation of 7-amino-3-methoxymeth- yl-ceph-3-em-4-carboxylic acid.
ES8106147A1 (en) 1,2,4-Triazole-3-thiols as antisecretory agents
GB8330731D0 (en) Chemical compounds
JPS6438062A (en) Novel alkylenediamine derivative and glutamic acid blocking agent
JPS5524127A (en) 3,6-endomethylene-delta4-1,2,3,6-tetrahydrophtalimide derivative
ZA877851B (en) 1-hydroxyalkylxanthines,processes for their preparation and medicaments containing them
JPS5515457A (en) Dithiocarbamic acid derivative