JPS649938A - Oral ingestive composition - Google Patents
Oral ingestive compositionInfo
- Publication number
- JPS649938A JPS649938A JP62163510A JP16351087A JPS649938A JP S649938 A JPS649938 A JP S649938A JP 62163510 A JP62163510 A JP 62163510A JP 16351087 A JP16351087 A JP 16351087A JP S649938 A JPS649938 A JP S649938A
- Authority
- JP
- Japan
- Prior art keywords
- oral
- ingestive
- oral administration
- peptide
- mentioned
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003382 ingestive effect Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 241000283690 Bos taurus Species 0.000 abstract 1
- 206010025476 Malabsorption Diseases 0.000 abstract 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 239000005018 casein Substances 0.000 abstract 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract 1
- 235000021240 caseins Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PURPOSE:To obtain an oral ingestive composition containing a compound peptide or acid addition salt thereof as an active ingredient, having high safety and effective in oral administration. CONSTITUTION:An oral ingestive composition containing a peptide expressed by the formula or acid addition salt thereof as an active ingredient. The above- mentioned peptide is a partial structural substance of bovine casein and obtained by hydrolyzing the above-mentioned protein with trypsin. An organic chemical synthetic technique can be more advantageously used. Although physiologically active peptides are difficult to exhibit effective physiological activity by oral administration because of hydrolysis and inactivation by digestive tract juice or malabsorption from digestive tracts, etc., the afore-mentioned peptides exhibit powerful hypotensive action by oral administration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62163510A JPS649938A (en) | 1987-06-30 | 1987-06-30 | Oral ingestive composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62163510A JPS649938A (en) | 1987-06-30 | 1987-06-30 | Oral ingestive composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS649938A true JPS649938A (en) | 1989-01-13 |
Family
ID=15775236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62163510A Pending JPS649938A (en) | 1987-06-30 | 1987-06-30 | Oral ingestive composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS649938A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999039730A1 (en) * | 1998-02-09 | 1999-08-12 | Kaken Pharmaceutical Co., Ltd. | Oral preparations containing peptides promoting the secretion of growth hormone |
| US8748573B2 (en) | 2009-08-06 | 2014-06-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| US8802628B2 (en) | 2008-08-15 | 2014-08-12 | Ironwood Pharmaceuticals, Inc. | Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration |
| US8933030B2 (en) | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| US10675325B2 (en) | 2010-08-11 | 2020-06-09 | Ironwood Pharmaceuticals, Inc. | Stable formulations of linaclotide |
-
1987
- 1987-06-30 JP JP62163510A patent/JPS649938A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999039730A1 (en) * | 1998-02-09 | 1999-08-12 | Kaken Pharmaceutical Co., Ltd. | Oral preparations containing peptides promoting the secretion of growth hormone |
| US8802628B2 (en) | 2008-08-15 | 2014-08-12 | Ironwood Pharmaceuticals, Inc. | Stable solid formulation of a GC-C receptor agonist polypeptide suitable for oral administration |
| US8748573B2 (en) | 2009-08-06 | 2014-06-10 | Ironwood Pharmaceuticals, Inc. | Formulations comprising linaclotide |
| US8933030B2 (en) | 2010-02-17 | 2015-01-13 | Ironwwod Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| US10675325B2 (en) | 2010-08-11 | 2020-06-09 | Ironwood Pharmaceuticals, Inc. | Stable formulations of linaclotide |
| US10702576B2 (en) | 2010-08-11 | 2020-07-07 | Ironwood Pharmaceuticals, Inc. | Stable formulations of linaclotide |
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