JPS649982A - 1,5-benzothiazepine derivative - Google Patents

1,5-benzothiazepine derivative

Info

Publication number
JPS649982A
JPS649982A JP16421187A JP16421187A JPS649982A JP S649982 A JPS649982 A JP S649982A JP 16421187 A JP16421187 A JP 16421187A JP 16421187 A JP16421187 A JP 16421187A JP S649982 A JPS649982 A JP S649982A
Authority
JP
Japan
Prior art keywords
lower alkyl
formula
halogen
compound
vasodilator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16421187A
Other languages
Japanese (ja)
Inventor
Hirozumi Inoue
Mitsunori Gaino
Hiroshi Nagao
Sakae Murata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP16421187A priority Critical patent/JPS649982A/en
Publication of JPS649982A publication Critical patent/JPS649982A/en
Pending legal-status Critical Current

Links

Landscapes

  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [R<1> is lower alkyl or lower alkoxy; R<2> is lower alkyl, aryl or aralkyl; R<3> is di- lower alkylamino; Alk is lower alkylene; R<4> is H, halogen, OH or lower alkyl or lower alkoxy; n is 1 or 2; with the proviso that R<4> is not H when R<2> is lower alkyl) or an acid addition salt thereof. EXAMPLE:(+ or -)-cis-2-(4-Methoxyphenyl)-3-(phenoxycarbonyl)oxy-5-[2-(dimethylami no)ethyl]2,3-dihydro-1,5-benzothiazepin-4(5H)-one. USE:A hypotensor, cerebrovascular vasodilator, coronary vasodilator, a drug for alleviating calmodulin and an inhibitor of blood platelet aggregation. PREPARATION:A compound (salt) shown by formula II is reacted with a com pound shown by the formula R<2>COOX (X is halogen) in a solvent such as methyl ene chloride in the presence of a deoxidizer at 0-60 deg.C.
JP16421187A 1987-06-30 1987-06-30 1,5-benzothiazepine derivative Pending JPS649982A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16421187A JPS649982A (en) 1987-06-30 1987-06-30 1,5-benzothiazepine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16421187A JPS649982A (en) 1987-06-30 1987-06-30 1,5-benzothiazepine derivative

Publications (1)

Publication Number Publication Date
JPS649982A true JPS649982A (en) 1989-01-13

Family

ID=15788777

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16421187A Pending JPS649982A (en) 1987-06-30 1987-06-30 1,5-benzothiazepine derivative

Country Status (1)

Country Link
JP (1) JPS649982A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0390072A (en) * 1989-08-31 1991-04-16 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative
JPH06206819A (en) * 1992-10-23 1994-07-26 Tanabe Seiyaku Co Ltd Peripheral circulation improving agent
JP2016011095A (en) * 2014-06-30 2016-01-21 日立オートモティブシステムズ株式会社 Brake device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60202871A (en) * 1984-03-10 1985-10-14 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative and its preparation

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0390072A (en) * 1989-08-31 1991-04-16 Tanabe Seiyaku Co Ltd 1,5-benzothiazepine derivative
JPH06206819A (en) * 1992-10-23 1994-07-26 Tanabe Seiyaku Co Ltd Peripheral circulation improving agent
JP2016011095A (en) * 2014-06-30 2016-01-21 日立オートモティブシステムズ株式会社 Brake device

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