JPS649997A - Serine protease inhibitor - Google Patents
Serine protease inhibitorInfo
- Publication number
- JPS649997A JPS649997A JP62165901A JP16590187A JPS649997A JP S649997 A JPS649997 A JP S649997A JP 62165901 A JP62165901 A JP 62165901A JP 16590187 A JP16590187 A JP 16590187A JP S649997 A JPS649997 A JP S649997A
- Authority
- JP
- Japan
- Prior art keywords
- medullasin
- subjected
- formula
- protease inhibitor
- serine protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940122055 Serine protease inhibitor Drugs 0.000 title abstract 2
- 101710102218 Serine protease inhibitor Proteins 0.000 title abstract 2
- 239000003001 serine protease inhibitor Substances 0.000 title abstract 2
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- 102100033174 Neutrophil elastase Human genes 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 108010017026 medullasin Proteins 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- PBCJIPOGFJYBJE-UHFFFAOYSA-N acetonitrile;hydrate Chemical compound O.CC#N PBCJIPOGFJYBJE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000000066 myeloid cell Anatomy 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 238000010257 thawing Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A serine protease inhibitor having amino acid sequence expressed by the formula (X is H or H-Val-Cys). USE:A remedy for inflammation having medullasin inhibiting ability. PREPARATION:For example, human myeloid cell is subjected to freeze thawing and 70% acetone is added to centrifuge supernatant thereof to the resultant precipitation, which is then extracted and the extract liquid is charged into a dialyzing membrane to carry out dialysis to water. Then the dialyzed outer liquid is concentrated and subjected to lyopilization and the dried product is dissolved in 20% acetonitrile containing 0.1% trifluoroacetic acid and purified using water-acetonitrile based linear gradient with reverse phase high speed liquid chromatography and fraction having medullasin inhibiting activity is collected to provide the compound expressed by the formula.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62165901A JPS649997A (en) | 1987-07-02 | 1987-07-02 | Serine protease inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62165901A JPS649997A (en) | 1987-07-02 | 1987-07-02 | Serine protease inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS649997A true JPS649997A (en) | 1989-01-13 |
Family
ID=15821143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62165901A Pending JPS649997A (en) | 1987-07-02 | 1987-07-02 | Serine protease inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS649997A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006018431A3 (en) * | 2004-08-18 | 2006-06-08 | Ipf Pharmaceuticals Gmbh | Peptides for the treatment of herpes virus infections |
-
1987
- 1987-07-02 JP JP62165901A patent/JPS649997A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006018431A3 (en) * | 2004-08-18 | 2006-06-08 | Ipf Pharmaceuticals Gmbh | Peptides for the treatment of herpes virus infections |
| JP2008509969A (en) * | 2004-08-18 | 2008-04-03 | イーペーエフ ファルマシューティカルス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Peptides for the treatment of herpes virus infection |
| US7741287B2 (en) | 2004-08-18 | 2010-06-22 | Ipf Pharmaceuticals Gmbh | Peptides for the treatment of herpes virus infections |
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