JPWO2012128363A1 - Ｐｅｄｆマイクロニードルアレイ及びその製造方法 - Google Patents

Ｐｅｄｆマイクロニードルアレイ及びその製造方法 Download PDF

Info

Publication number: JPWO2012128363A1
Authority: JP; Japan
Prior art keywords: pedf; microneedle; microneedle array; peptide; array according
Prior art date: 2011-03-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP2013506042A

Other languages

English (en)

Japanese (ja)

Inventor

英淑権

文男神山

彩子母里

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

UP WELL CO. LTD.

CosMED Pharmaceutical Co Ltd

Original Assignee

UP WELL CO. LTD.

CosMED Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-03-24

Filing date

2012-03-23

Publication date

2014-07-24

2012-03-23 Application filed by UP WELL CO. LTD., CosMED Pharmaceutical Co Ltd filed Critical UP WELL CO. LTD.

2014-07-24 Publication of JPWO2012128363A1 publication Critical patent/JPWO2012128363A1/ja

Status Pending legal-status Critical Current

Links

108090000102 pigment epithelium-derived factor Proteins 0.000 title claims abstract description 93
102100035846 Pigment epithelium-derived factor Human genes 0.000 title claims abstract description 85
238000004519 manufacturing process Methods 0.000 title description 11
239000003814 drug Substances 0.000 claims abstract description 31
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 30
229940079593 drug Drugs 0.000 claims abstract description 29
239000000463 material Substances 0.000 claims abstract description 29
230000036961 partial effect Effects 0.000 claims abstract description 16
230000003779 hair growth Effects 0.000 claims abstract description 13
201000004384 Alopecia Diseases 0.000 claims abstract description 9
150000004676 glycans Chemical class 0.000 claims abstract description 9
208000024963 hair loss Diseases 0.000 claims abstract description 9
230000003676 hair loss Effects 0.000 claims abstract description 9
229920001282 polysaccharide Polymers 0.000 claims abstract description 9
239000005017 polysaccharide Substances 0.000 claims abstract description 9
229920003169 water-soluble polymer Polymers 0.000 claims abstract description 6
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 4
230000001629 suppression Effects 0.000 claims abstract 2
238000000034 method Methods 0.000 claims description 36
239000000203 mixture Substances 0.000 claims description 25
238000003466 welding Methods 0.000 claims description 9
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 8
239000000853 adhesive Substances 0.000 claims description 8
230000001070 adhesive effect Effects 0.000 claims description 8
229920002674 hyaluronan Polymers 0.000 claims description 8
229960003160 hyaluronic acid Drugs 0.000 claims description 8
OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims description 5
101710176384 Peptide 1 Proteins 0.000 claims description 5
VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 claims description 3
150000002016 disaccharides Chemical class 0.000 claims description 2
150000002772 monosaccharides Chemical class 0.000 claims description 2
230000001172 regenerating effect Effects 0.000 claims 1
210000003491 skin Anatomy 0.000 abstract description 37
210000000434 stratum corneum Anatomy 0.000 abstract description 7
239000002344 surface layer Substances 0.000 abstract description 6
230000000717 retained effect Effects 0.000 abstract 1
239000000758 substrate Substances 0.000 description 23
239000007864 aqueous solution Substances 0.000 description 12
238000002347 injection Methods 0.000 description 9
239000007924 injection Substances 0.000 description 9
239000002313 adhesive film Substances 0.000 description 8
229960001231 choline Drugs 0.000 description 8
230000002950 deficient Effects 0.000 description 8
235000005911 diet Nutrition 0.000 description 8
230000037213 diet Effects 0.000 description 8
239000000243 solution Substances 0.000 description 8
OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 7
125000003275 alpha amino acid group Chemical group 0.000 description 6
230000000694 effects Effects 0.000 description 6
241000699670 Mus sp. Species 0.000 description 5
230000002401 inhibitory effect Effects 0.000 description 5
238000012360 testing method Methods 0.000 description 5
101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 description 4
241000700159 Rattus Species 0.000 description 4
238000003491 array Methods 0.000 description 4
238000004090 dissolution Methods 0.000 description 4
239000011782 vitamin Substances 0.000 description 4
229940088594 vitamin Drugs 0.000 description 4
229930003231 vitamin Natural products 0.000 description 4
235000013343 vitamin Nutrition 0.000 description 4
150000003722 vitamin derivatives Chemical class 0.000 description 4
229920002307 Dextran Polymers 0.000 description 3
241001465754 Metazoa Species 0.000 description 3
238000011156 evaluation Methods 0.000 description 3
238000010438 heat treatment Methods 0.000 description 3
229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
239000001267 polyvinylpyrrolidone Substances 0.000 description 3
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
230000001681 protective effect Effects 0.000 description 3
235000018102 proteins Nutrition 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
108090000623 proteins and genes Proteins 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
LVWIJITYHRZHBO-IXOXFDKPSA-N His-Leu-Thr Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LVWIJITYHRZHBO-IXOXFDKPSA-N 0.000 description 2
MJVAVZPDRWSRRC-UHFFFAOYSA-N Menadione Chemical compound C1=CC=C2C(=O)C(C)=CC(=O)C2=C1 MJVAVZPDRWSRRC-UHFFFAOYSA-N 0.000 description 2
WWPAHTZOWURIMR-ULQDDVLXSA-N Phe-Pro-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CC1=CC=CC=C1 WWPAHTZOWURIMR-ULQDDVLXSA-N 0.000 description 2
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
238000005227 gel permeation chromatography Methods 0.000 description 2
239000008103 glucose Substances 0.000 description 2
235000021552 granulated sugar Nutrition 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000011707 mineral Substances 0.000 description 2
GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
-1 polyethylene Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
230000002829 reductive effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
229920001059 synthetic polymer Polymers 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
FZWBNHMXJMCXLU-UHFFFAOYSA-N 2,3,4,5-tetrahydroxy-6-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxyhexanal Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OCC(O)C(O)C(O)C(O)C=O)O1 FZWBNHMXJMCXLU-UHFFFAOYSA-N 0.000 description 1
ROGIWVXWXZRRMZ-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1 ROGIWVXWXZRRMZ-UHFFFAOYSA-N 0.000 description 1
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
FUHFYEKSGWOWGZ-XHNCKOQMSA-N Asn-Gln-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)N)C(=O)O FUHFYEKSGWOWGZ-XHNCKOQMSA-N 0.000 description 1
ZQFZEBRNAMXXJV-KKUMJFAQSA-N Asp-Tyr-His Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC2=CN=CN2)C(=O)O)NC(=O)[C@H](CC(=O)O)N)O ZQFZEBRNAMXXJV-KKUMJFAQSA-N 0.000 description 1
229920002799 BoPET Polymers 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
229920001661 Chitosan Polymers 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
241000725101 Clea Species 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
241001391944 Commicarpus scandens Species 0.000 description 1
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
235000019393 L-cystine Nutrition 0.000 description 1
239000004158 L-cystine Substances 0.000 description 1
SENJXOPIZNYLHU-UHFFFAOYSA-N L-leucyl-L-arginine Natural products CC(C)CC(N)C(=O)NC(C(O)=O)CCCN=C(N)N SENJXOPIZNYLHU-UHFFFAOYSA-N 0.000 description 1
RFUBXQQFJFGJFV-GUBZILKMSA-N Leu-Asn-Gln Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O RFUBXQQFJFGJFV-GUBZILKMSA-N 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
BWTKUQPNOMMKMA-FIRPJDEBSA-N Phe-Ile-Phe Chemical compound C([C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 BWTKUQPNOMMKMA-FIRPJDEBSA-N 0.000 description 1
JTKGCYOOJLUETJ-ULQDDVLXSA-N Phe-Val-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](N)CC1=CC=CC=C1 JTKGCYOOJLUETJ-ULQDDVLXSA-N 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
229920003078 Povidone K 12 Polymers 0.000 description 1
MHBSUKYVBZVQRW-HJWJTTGWSA-N Pro-Phe-Ile Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O MHBSUKYVBZVQRW-HJWJTTGWSA-N 0.000 description 1
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
229920002385 Sodium hyaluronate Polymers 0.000 description 1
FBHBVXUBTYVCRU-BZSNNMDCSA-N Tyr-His-Leu Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CN=CN1 FBHBVXUBTYVCRU-BZSNNMDCSA-N 0.000 description 1
OTJMMKPMLUNTQT-AVGNSLFASA-N Val-Leu-Arg Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)NC(=O)[C@H](C(C)C)N OTJMMKPMLUNTQT-AVGNSLFASA-N 0.000 description 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
229930003451 Vitamin B1 Natural products 0.000 description 1
229930003471 Vitamin B2 Natural products 0.000 description 1
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
239000003522 acrylic cement Substances 0.000 description 1
238000007792 addition Methods 0.000 description 1
239000012790 adhesive layer Substances 0.000 description 1
239000002390 adhesive tape Substances 0.000 description 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
230000004888 barrier function Effects 0.000 description 1
229920006167 biodegradable resin Polymers 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
238000005520 cutting process Methods 0.000 description 1
229960003067 cystine Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000000593 degrading effect Effects 0.000 description 1
238000012217 deletion Methods 0.000 description 1
230000037430 deletion Effects 0.000 description 1
229960002086 dextran Drugs 0.000 description 1
229940119743 dextran 70 Drugs 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
239000006260 foam Substances 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000012634 fragment Substances 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
238000007542 hardness measurement Methods 0.000 description 1
108010025306 histidylleucine Proteins 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
108010000761 leucylarginine Proteins 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000010369 molecular cloning Methods 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229940105631 nembutal Drugs 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
244000052769 pathogen Species 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
108010084572 phenylalanyl-valine Proteins 0.000 description 1
229920006267 polyester film Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
229920006264 polyurethane film Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
150000003248 quinolines Chemical class 0.000 description 1
239000002994 raw material Substances 0.000 description 1
230000003763 resistance to breakage Effects 0.000 description 1
229960002477 riboflavin Drugs 0.000 description 1
229940010747 sodium hyaluronate Drugs 0.000 description 1
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
CCEKAJIANROZEO-UHFFFAOYSA-N sulfluramid Chemical group CCNS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F CCEKAJIANROZEO-UHFFFAOYSA-N 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229920002725 thermoplastic elastomer Polymers 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
230000003813 thin hair Effects 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000010374 vitamin B1 Nutrition 0.000 description 1
239000011691 vitamin B1 Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
235000019158 vitamin B6 Nutrition 0.000 description 1
239000011726 vitamin B6 Substances 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
235000012711 vitamin K3 Nutrition 0.000 description 1
239000011652 vitamin K3 Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940011671 vitamin b6 Drugs 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Medical Informatics (AREA)
Anesthesiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

JP2013506042A 2011-03-24 2012-03-23 Ｐｅｄｆマイクロニードルアレイ及びその製造方法 Pending JPWO2012128363A1 (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP2011087736		2011-03-24
JP2011087736		2011-03-24
PCT/JP2012/057598 WO2012128363A1 (fr)	2011-03-24	2012-03-23	Réseau de micro-aiguilles en pedf et procédé pour produire celui-ci

Publications (1)

Publication Number	Publication Date
JPWO2012128363A1 true JPWO2012128363A1 (ja)	2014-07-24

Family

ID=46879501

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2013506042A Pending JPWO2012128363A1 (ja)	2011-03-24	2012-03-23	Ｐｅｄｆマイクロニードルアレイ及びその製造方法

Country Status (2)

Country	Link
JP (1)	JPWO2012128363A1 (fr)
WO (1)	WO2012128363A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN111526918A (zh) *	2017-12-26	2020-08-11	三岛光产株式会社	微针阵列

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP6323975B2 (ja) *	2012-06-22	2018-05-16	凸版印刷株式会社	針状体の製造方法
JPWO2014142135A1 (ja) *	2013-03-12	2017-02-16	武田薬品工業株式会社	マイクロニードルパッチ
US20160279401A1 (en)	2015-03-27	2016-09-29	Allergan, Inc.	Dissolvable microneedles for skin treatment
JP6970954B2 (ja)	2016-03-16	2021-11-24	コスメディ製薬株式会社	フコイダン育毛剤
WO2018043574A1 (fr) *	2016-09-01	2018-03-08	久光製薬株式会社	Feuille à micro-aiguilles
JP7116430B2 (ja)	2016-12-12	2022-08-10	株式会社メドレックス	マイクロニードル貼付剤
AU2018222745B2 (en)	2017-02-17	2021-02-18	Allergan, Inc.	Microneedle array with active ingredient
WO2019088315A1 (fr) *	2017-11-01	2019-05-09	주식회사 엘지생활건강	Patch de micro-aiguilles solubles pour transférer un agent de prévention de la chute des cheveux et un agent de traitement stimulant la pousse des cheveux
ES3034959T3 (en)	2018-03-13	2025-08-27	Medrx Co Ltd	Adhesion member and microneedle patch
AU2021209105B2 (en) *	2020-01-16	2026-02-12	Kansas State University Research Foundation	Microneedle, microcone, and photolithography fabrication methods
JP2023523952A (ja)	2020-04-28	2023-06-08	ティコナ・エルエルシー	マイクロニードルアセンブリ
US20250121168A1 (en) *	2021-08-20	2025-04-17	Cosmed Pharmaceutical Co., Ltd.	High-performance microneedle array

Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050148508A1 (en) *	2002-01-03	2005-07-07	Shmuel Shaltiel	Pigment epithelium derived factor from human plasma and methods of use thereof
JP2007197330A (ja) *	2006-01-23	2007-08-09	Seitai Shigen Laboratory Inc	脱毛抑制または発毛促進用組成物
JP2007291009A (ja) *	2006-04-25	2007-11-08	Seitai Shigen Laboratory Inc	血管内膜肥厚抑制剤
WO2008139648A1 (fr) *	2007-05-15	2008-11-20	Hisamitsu Pharmaceutical Co., Inc.	Procédé de revêtement d'une micro-aiguille
JP2009522269A (ja) *	2005-12-30	2009-06-11	ニューロテックユーエスエー，インコーポレイテッド	生物活性分子の送達のための微粒子化デバイスおよびその使用方法
JP2009535371A (ja) *	2006-05-04	2009-10-01	フォベア、ファルマスティカル、ソシエテ、アノニム	血管新生性疾患の治療のための方法
WO2011002034A1 (fr) *	2009-07-01	2011-01-06	凸版印刷株式会社	Matériau de type aiguille
JP2011508611A (ja) *	2007-10-08	2011-03-17	オセルスリミテッド	生物学的障壁を通した薬剤送達用の無針装置

2012
- 2012-03-23 WO PCT/JP2012/057598 patent/WO2012128363A1/fr not_active Ceased
- 2012-03-23 JP JP2013506042A patent/JPWO2012128363A1/ja active Pending

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050148508A1 (en) *	2002-01-03	2005-07-07	Shmuel Shaltiel	Pigment epithelium derived factor from human plasma and methods of use thereof
JP2009522269A (ja) *	2005-12-30	2009-06-11	ニューロテックユーエスエー，インコーポレイテッド	生物活性分子の送達のための微粒子化デバイスおよびその使用方法
JP2007197330A (ja) *	2006-01-23	2007-08-09	Seitai Shigen Laboratory Inc	脱毛抑制または発毛促進用組成物
JP2007291009A (ja) *	2006-04-25	2007-11-08	Seitai Shigen Laboratory Inc	血管内膜肥厚抑制剤
JP2009535371A (ja) *	2006-05-04	2009-10-01	フォベア、ファルマスティカル、ソシエテ、アノニム	血管新生性疾患の治療のための方法
WO2008139648A1 (fr) *	2007-05-15	2008-11-20	Hisamitsu Pharmaceutical Co., Inc.	Procédé de revêtement d'une micro-aiguille
JP2011508611A (ja) *	2007-10-08	2011-03-17	オセルスリミテッド	生物学的障壁を通した薬剤送達用の無針装置
WO2011002034A1 (fr) *	2009-07-01	2011-01-06	凸版印刷株式会社	Matériau de type aiguille

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN111526918A (zh) *	2017-12-26	2020-08-11	三岛光产株式会社	微针阵列

Also Published As

Publication number	Publication date
WO2012128363A1 (fr)	2012-09-27

Legal Events

Date	Code	Title	Description
2015-03-02	A621	Written request for application examination	Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150302
2015-11-25	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20151124
2015-12-15	A521	Written amendment	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151215
2016-01-07	A521	Written amendment	Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20151215
2016-01-25	A521	Written amendment	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160125
2016-07-05	A02	Decision of refusal	Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160705

Publication	Publication Date	Title
JPWO2012128363A1 (ja)	2014-07-24	Ｐｅｄｆマイクロニードルアレイ及びその製造方法
JP4427691B2 (ja)	2010-03-10	マイクロニードルアレイ
US11419816B2 (en)	2022-08-23	Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP6865524B2 (ja)	2021-04-28	治療剤を送達するためのマイクロアレイおよび使用方法
AU2013219321B2 (en)	2017-07-20	Microneedle of short-time dissolution type
CA3067660C (fr)	2022-11-15	Reseau de micro-aiguilles d'anesthesie locale dentaire
JP4521492B2 (ja)	2010-08-11	マイクロニードルアレイ及びその製造方法
JP2016511014A5 (fr)	2017-02-09
JP2010082401A (ja)	2010-04-15	マイクロニードルアレイ
CN107349175A (zh)	2017-11-17	一种负载脂肪褐变剂的微针贴片及其制备方法
JP2009254756A (ja)	2009-11-05	マイクロニードルアレイ
US20240366921A1 (en)	2024-11-07	Microneedle patch for immunostimulatory drug delivery
TW201836658A (zh)	2018-10-16	微針裝置
CN121313849A (zh)	2026-01-13	用于治疗婴幼儿血管瘤的系统及其微针和应用
CA3218769A1 (fr)	2022-11-24	Timbre a micro-aiguilles pour administration de medicament immunostimulant
US20260027041A1 (en)	2026-01-29	Formulations and Methods for a GLP-1 Agonist Microneedle Patch
Yaturu et al.	2013	Insulin therapy for diabetes
EP4403202A1 (fr)	2024-07-24	Réseau de micro-aiguilles revêtu de médicament
Abbasi et al.	2020	Transdermal delivery of metformin using microneedle and iontophoresis for combating obesity
CN118750435A (zh)	2024-10-11	一种舒芬太尼微针贴片及其制备方法和应用
Queiroz et al.	2020	Microneedles as an alternative technology for transdermal drug delivery systems: a patent

JPWO2012128363A1 - Ｐｅｄｆマイクロニードルアレイ及びその製造方法 - Google Patents

Info

Links

Images

Classifications

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=46879501

Family Applications (1)

Country Status (2)

Cited By (1)

Families Citing this family (12)

Citations (8)

Patent Citations (8)

Cited By (1)

Also Published As

Similar Documents

Legal Events