KR101502912B1 - Mask pack using temperature-responsive sol-gel transfer hydro-gel - Google Patents

Abstract

The present invention relates to a mask pack using a thermosensitive sol-gel transition gel, and more particularly, to a mask pack comprising a hydrophilic polymer or amphipathic polymer containing two or more phosphate groups and a polyvalent cation corresponding to the negative charge of the phosphate group, And a temperature responsive mask pack comprising the skin active ingredient, wherein the sol-gel transition hydrate gel is thermally sensitive to transition from a sol state to a gel state in a temperature range of 10 to 50 ° C.
Since the mask pack using the thermosensitive sol-gel transition hydrogel according to the present invention uses a thermosensitive hydrogel in which a state transition is made in a sol state at a low temperature and a state transition to a sol state at a body temperature range, It is possible to minimize the evaporation of the skin active ingredient and to improve the absorption power and the utilization ratio of the skin active ingredient by continuing the water retention ability by applying the skin rapidly and forming the film by gelation of the hydrogel after the skin temperature .

Description

(Mask pack using temperature-responsive sol-gel transfer hydro-gel) using a thermosensitive sol-

The present invention relates to a mask pack using a thermosensitive sol-gel transition hydrogel, and it relates to a mask pack using a temperature-sensitive sol-gel transition hydrate gel, which is capable of rapidly transferring skin active ingredients to the skin, To a mask pack which can be improved.

In general, the pack is used for a predetermined period of time by using a nutritional ingredient or a skin active ingredient, which can affect the skin, at a desired site so that a desired effect can be seen on the skin. The pack has been used for a long time as a main cosmetic which keeps the skin healthy and beautiful by performing moisturizing action to keep moisture on the skin, adsorption and removal of skin contaminants, and cleansing action and blood circulation promoting action. Among them, a mask pack can be said to be manufactured for use on facial skin.

Conventional manufacture of a cosmetic mask pack is performed by applying a cosmetic liquid or a cosmetic such as natural or synthetic material known to be functional to a nonwoven fabric support made of synthetic fibers such as polyester or nylon, Studies have been actively conducted on a support on which the cosmetic ingredients contained in the mask pack are changed or added or on which the cosmetic ingredients are applied. The cosmetic component of the mask pack and the type of the support to which the cosmetic component is applied are various, and the support is cut into a face shape, and the cosmetic component is coated on one side thereof.

However, since the nonwoven fabric is often added with a synthetic polymer according to the manufacturing process, the addition of a cosmetic liquid may cause stiffness, resulting in poor feeling of use and poor skin compatibility. In addition, in the case of a formulation in which the nonwoven fabric is soaked in an additive such as a solution containing the active ingredient to induce absorption of the active ingredient, the skin adhesion is poor. In the early stage, too high concentration of the skin active ingredient comes into contact with the skin, And 10 minutes to 15 minutes, the moisture is evaporated and dried, and the mask pack drops from the face.

In order to overcome the disadvantages of such conventional mask packs, research and development on hydrogel mask packs have been actively conducted.

Hydrogel is a three-dimensional hydrophilic polymer network with purified water as a dispersion medium. It has the ability to absorb a large amount of water and has the same flexibility as a natural tissue. In addition, hydrogels can be added with new features such as controlled release that can control the delivery of the contained material and sensitivity to the pH, temperature, electric field and light stimulated expansion or contraction. Hydrogels having such properties are widely used in the pharmaceutical industry as well as cosmetics and biomedical medical care due to advantages similar to the structure of the human cell, inert biocompatibility, elasticity such as rubber, and excellent permeability of oxygen and nutrients. In recent years, a mask pack has been developed which is improved in moisturizing, nutritional supply or exfoliation effect by utilizing elasticity, skin adhesion, and soft touch of a hydrogel. A hydrogel is used to improve the appearance of the skin, such as wrinkle improvement, skin whitening, ultraviolet ray shielding, nutritional supply, skin elasticity, moisturizing etc. by adding various functional cosmetic ingredients, moisturizing agents, Various effects can be delivered to the skin.

However, the conventional technique of applying the hydrogel to the skin has only the function of slowly releasing the active component of the skin contained in the supported hydrogel to the skin while maintaining the gel state as it is, A relatively long time is required to penetrate the skin to allow the active substance to be applied to the skin while maintaining the same, and the drug is delivered only to a limited region where the hydrogel contacts the skin. In addition, there is a problem that the skin active ingredient is not easily injected into the hydrogel.

In order to solve such a problem, Korean Patent No. 10-0506543 discloses a hydrogel composition, which is used to rapidly and evenly transfer a skin active ingredient into the skin, Sensitive hydrogel having a function of allowing the skin active ingredient to penetrate into the skin quickly and uniformly so that the hydrogel composition having flowability is changed evenly and the skin is uniformly coated on the skin. In this technique, the affinity between the skin and the hydrogel is improved by using the gelated polymer and the gelated polymer having the characteristic of changing from the solid state gel state to the liquid state state at the temperature near the body temperature, and by adding the affinity enhancing agent Describes a technique whereby a large amount of cosmetic ingredients can be rapidly transferred from the hydrogel composition to the skin. However, since the solid phase gel is phase-changed by the body temperature, the phase change takes time and the liquid phase is mostly evaporated, so that the active ingredient evaporates after the liquid phase change, And as a result, the use efficiency of the skin active component is lowered.

Accordingly, there has been a great need to develop a mask pack technology capable of sustaining moisture retaining ability so that a skin active ingredient can be rapidly delivered to the skin, but the skin active ingredient is not easily evaporated to the outside.

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide a method for preparing a skin active ingredient, which comprises applying a skin active ingredient onto a skin by a transition from a sol state to a gel state, The present invention provides a mask pack capable of sustaining moisture retention by forming a film, minimizing evaporation of the skin active ingredient, and thus improving the absorption power and utilization of the skin active ingredient.

As a means for solving the above-mentioned problems,

A hydrophilic polymer or amphipathic polymer containing two or more phosphate groups on a mask pack support and a polyvalent cation corresponding to the negative charge of the phosphate group and then aging and aging in a temperature range of 10 to 50 ° C to form a gel state The present invention provides a mask pack using a sol-gel-transferred hydrogel having a temperature-responsive temperature sensitivity and a temperature-sensitive sol-gel transition hydrogel containing a skin active ingredient.

The characteristics and advantages of the mask pack using the thermosensitive sol-gel transferred hydrogel according to the present invention will be described below.

First, the mask pack according to the present invention is applied to the skin in a wet state on a support. Since the mask pack maintains a liquid state sol state at first, it promotes permeation of skin active ingredients to the skin, .

In addition, when the moisture of the skin is not maintained after the initial skin permeation, the active ingredient of the skin is evaporated to the outside. In the temperature-sensitive sol-gel transition gel used in the present invention, To form a film, it is possible to prevent external evaporation of the skin active ingredient. Therefore, it has an effect of maximizing the absorption rate and utilization rate of the skin active ingredient.

Fig. 1 schematically shows the LCST behavior of the thermosensitive sol-gel transition gel according to an embodiment of the present invention.
FIG. 2 is a graph showing the sol-gel phase transition according to pH change of the polymer included in the thermosensitive sol-gel transition gel according to an embodiment of the present invention.
3 is a graph showing the sol-gel phase transition according to calcium ions added to the thermosensitive sol-gel transition gel according to an embodiment of the present invention.
4 is a graph showing the sol-gel phase transition according to the kind of additives contained in the thermosensitive sol-gel transition gel according to an embodiment of the present invention.
FIG. 5 is a graph showing the sol-gel phase transition of a thermosensitive sol-gel transferred hydrogel according to an embodiment of the present invention. FIG.

Hereinafter, the present invention will be described in detail.

The mask pack according to the present invention is prepared by mixing a hydrophilic polymer or an amphipathic polymer containing two or more phosphate groups on a mask pack support and a polyvalent cation corresponding to the negative charge of the phosphate group and then aging, Gel-transferred hydrogel having a temperature sensitivity to transition from a sol state to a gel state, and a skin active component.

More specifically, it comprises 1 to 30% by weight of the thermosensitive sol-gel transition gel, 1 to 20% by weight of a skin active ingredient, 1 to 30% by weight of various additives, and residual water on the mask pack support Thereby providing a mask pack.

The present inventors have developed a hydrogel containing a polymer having an anion and a cation through a patent (Korean Patent Application No. 10-2012-0111691), and by controlling the phase transition temperature and mechanical properties of the hydrogel, gel persistence is improved, A hydrogel having reactivity has been proposed. The present invention proposes a technique for improving the water retention ability of a mask pack by applying the technique proposed in the above-mentioned patent application, thereby increasing the utilization rate and absorption rate of the skin active ingredient and solving the problems of the conventional mask pack .

The mask pack support which can be used in the present invention may widely include a mask pack support in the form of a nonwoven fabric using conventional synthetic resins or natural fibers as well as a hydrogel sheet type mask pack support. However, since the sol-gel-transferred hydrogel and the skin active component are required to be absorbed in the support in the initial state, a mask pack support in the form of a nonwoven fabric is more preferable.

In the present invention, the thermosensitive sol-gel transition hydrate gel is prepared by mixing a hydrophilic polymer or amphipathic polymer containing two or more phosphate groups and a polyvalent cation corresponding to the negative charge of the phosphate group and then aging for a certain period of time, Deg.] C, more preferably in a temperature range close to the body temperature of 30 to 40 [deg.] C, from the sol state to the gel state.

In the present invention, the phosphate (PO ₄ ^2- ) group may be located at the end portion of the hydrophilic polymer or the amphipathic polymer. For example, the phosphate (PO ₄ ^2- ) group may be positioned at both ends of the polymer have. By mixing the polymer with a cation that provides a positive charge corresponding to the negative charge originating from the two or more phosphate groups contained in the polymer, a hydrogel having external stimulus sensitivity, specifically temperature sensitivity, can be obtained.

The hydrophilic polymer may be selected from the group consisting of polyethyleneglycol (PEG), poly N-isopropylacrylamide (PNIPAM), polymethylacrylate (PMA), polymethylmetacrylate (PMMA) (PVA), polyvinylpyrrolidone (PVP), polyethylene oxide (PEO), polyvinyl alcohol (PVA), polyacrylic acid Block, graft, or dendrimer hydrophilic polymers including those selected from the group consisting of cellulose, cellulose, collagen, alginate, chitosan, and combinations thereof. .

Also, in the present invention, the amphipathic polymer may be selected from the group consisting of polyethyleneglycol (PEG), poly N-isopropylacrylamide (PNIPAM), polymethylacrylate (PMA), polymethylmetacrylate (PMMA), polyacrylamide, polyacrylic acid (PAA), polymethacrylic acid (PMAA), polyvinylpyrrolidone (PVP), polyvinyl alcohol Block, graft or dendrimer hydrophilic polymer block comprising a polymer selected from the group consisting of methyl cellulose, polyethylene oxide (PEO), collagen, alginate, chitosan, and combinations thereof. ; And polypropylene oxide (PPO), polylactic acid (PLA), poly lactide-coglycolide (PLGA), polycaprolactone, polyvinylacetate (PVAc) A block, a graft, or a dendrimer hydrophobic polymer block including a polymer block selected from the group consisting of a polymer, a polypeptide, and a combination thereof.

The amphipathic polymer may comprise, for example, (PPO) x- (PEO) y- (PPO) z wherein each of x, y and z is independently 3 to 10000. Here, the PPO refers to polypropylene oxide, and the PEO refers to polyethylene oxide. In the above (PPO) x- (PEO) y- (PPO) z, PEO and PPO can be contained in a weight ratio of 1: 1 to 9.

In the present invention, the polyvalent cation is a metal cation having a valence of +2 or more; ^{_{-NH 3 +, -N + H 2}} (CH 3), -N + H (CH 3) 2 , and -N ⁺ (CH ₃₎ or a low molecular cationic polymer comprising at least two cations selected from ₃ (e.g. A chitosan or a bipyridine cation containing at least two of the above cations); And combinations thereof. Here, the metal cation having a valence of +2 or more may be selected from the group consisting of Mg ²⁺ , Ca ²⁺ , Fe ²⁺ , Fe ³⁺ , Al ³⁺ , Cu ²⁺ , Zn ²⁺ , .

When mixing with the polymer, a salt containing the metal cation having a valence of +2 or more may be used. Such a metal salt may be selected from known ones without any particular limitation. For example, a halogen salt, a carbonate salt, a nitrate salt, a sulfate salt, an acetate salt, etc. of the polyvalent metal cation can be used. The +2 or higher metal cation may be added, for example, from about 1 equivalent to about 3 equivalents.

The thermosensitive sol-gel transferred hydrogel according to the present invention is prepared by mixing a hydrophilic polymer having two or more phosphate groups or an amphipathic polymer with a polyvalent cation corresponding to the negative charge of the phosphate group and then aging. The aging time may be about 1 hour or more, preferably about 1 to 5 days.

The skin active ingredient used in the present invention may be a skin active ingredient which can function as a skin aging prevention, skin elasticity enhancement, wrinkle removal, whitening effect, moisture and nutrient supply, skin sedative action, circulatory action improvement, skin relaxation and exfoliation Active ingredients may be used. For example, natural materials extracted from plants, animals or minerals can be used. More specifically, there can be used aloe, green tea, ginseng, vinegar, pine leaf, propolis, ginkgo leaf, silkworm, mulberry leaf, And natural extract components extracted from at least one natural product selected from the group consisting of alfalfa, peanut, peanut, doe, mallow, licorice, safflower and licorice. It is preferable that the content is in the range of 1 to 10 parts by weight relative to 100 parts by weight of the thermosensitive sol-gel transition hydrated gel.

The additive that can be used in the present invention may be at least one selected from skin-affinity enhancers, polyhydric alcohols, gel stabilizers, and phase transition temperature adjusting agents.

The skin-affinity enhancer enhances affinity with the skin to rapidly transfer a large amount of the skin active ingredient to the skin, examples of which include, but are not limited to, chitosan, phthaloglycan, chitosan Polysaccharide or protein such as starch, starch, starch, starch, starch, starch, starch, starch, starch, starch, derivative, elastin, collagen or hyaruronic acid is contained in 0.5-5 parts by weight .

The polyhydric alcohol is a water-soluble liquid propylene glycol, glycerin, or the like, which is capable of penetrating the skin active component in close contact with the skin. The content of the polyhydric alcohol is in the range of 100 parts by weight to 100 parts by weight of the thermosensitive sol- 1 to 30 parts by weight.

The gel stabilizer is useful as an additive for imparting stability and functionality to a hydrogel such as methylparaben, propylparaben, kojic acid, -hydroxy acid, imidazolidinyl urea, retinol, etc. The content of the gel- It may be contained in the range of 1 to 10 parts by weight relative to 100 parts by weight of the transition hydrogenated gel.

The phase transition temperature controlling agent may be one or more selected from the group consisting of salts such as NaCl, CaCl ₂ and NaCSN and polymers such as PEG. The content may be in the range of 0.1 to 20 parts by weight relative to 100 parts by weight of the thermosensitive sol-gel transition hydrated gel.

In the present invention, the temperature-sensitive sol-gel-transferred hydrogel may be mixed with phosphate buffer or physiological saline, and may be adjusted to a suitable pH by adding a basic substance.

In the present invention, when a hydrophilic polymer or an amphipathic polymer containing two or more phosphate groups is mixed with a polyvalent cation corresponding to the negative charge of the phosphate group and then aged for a certain period of time, When exposed to a temperature stimulus in the skin temperature range, it contracts to form a gel. As a result, the lower critical solution temperature (LCST) is obtained, which decreases the solubility in water with increasing temperature. In the case of a polymer having such an LCST, when the temperature rises above the LCST, it is condensed and phase transition occurs from the soluble sol to the insoluble gel. At low temperature, the hydrogen bonding force between the hydrophilic group and the water molecule of the polymer predominates, so that it is dissolved in water and becomes a sol state. However, when the temperature is increased, the bonding power of the hydrophobic part of the polymer becomes higher than the hydrogen bonding force. Phase transition occurs in the gel state.

Fig. 1 schematically shows the LCST behavior of the thermosensitive sol-gel transition gel according to an embodiment of the present invention.

As shown in FIG. 1, when the temperature is elevated, the polymer chains are aligned in the same direction to form a rigid structure, thereby causing gelation and curing (B).

The temperature-sensitive sol-gel hydrogel according to the present invention is applied to a mask pack support in a state of being mixed with a skin active ingredient or layered below the skin active ingredient. After the skin active ingredient is appropriately applied to the skin, The gel is transformed into a gel to form a coating film, thereby enhancing water retention, thereby preventing the skin active component from evaporating out, thereby increasing the absorption rate to the skin and the utilization rate of the skin active ingredient.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the scope of the present invention should not be construed as being limited by the following Examples.

[Example 1]

Polymer PO ₄ ^2- -PPO-PEO-PPO-PO ₄ ^2- Synthesis of

Triethylamine (74.0 mmol, 10.4 mL) was added to the water-removed methylene chloride (100 mL) and stirred well. The flask was immersed in an ice water bath and phosphoryl chloride (POCl ₃ , 222.3 mmol, 20.7 mL) was slowly added over 30 minutes. A solution of Pluronic-R (7.41 mmol, 20 g) in methylene chloride (100 mL) with water removed was dropped dropwise at 0 ° C. The ice bath was left to stand for 24 hours so that the temperature gradually rose to room temperature. After 24 hours, the reaction solution was immersed in an ice water bath, cooled, and then the solvent was removed by distillation under reduced pressure. Then, cold water was added and the mixture was stirred at 60 ° C for 24 hours. After the reaction was completed, the reaction product was extracted with chloroform and vacuum-dried to obtain a product. An example of the synthesis scheme of the polymer is as follows.

The types of polymers used and the yields of the resulting materials are shown in Table 1 below.

Polymer PO ₄ ^2- -PPO-PEO-PPO-PO ₄ ^2- Structure analysis of

It was confirmed by the synthesized polymer ^{_{PO 4 2- -PPO-PEO-PPO-}} PO 4 2- one ¹ H NMR (400MHz, Bruker) to CDCl ₃ as a solvent and ^{measurement, 31 P NMR (500 MHz,} Bruker) measurement .

17R4-BDHP:

^{1 H NMR (400 MHz NMR,} CDCl 3) δ3.634 (s, -O CH 2 CH 2 -, ethylene), 3.605-3.468 (m, PO (OH) 2 OCH (CH 3) CH2 -, methylene), _{3.456-3.344 (m, -CH 2 CH (} CH 3) O-, methine), 1.146 (s, -CH 2 CH (CH 3) O-, methyl)

³¹ P NMR (500 MHz NMR, CDCl ₃ )? 1.616 (s, PO (OH) ₂ OCH (CH ₃ ) -, phosphate)

[Preparation Example 1] Production of 25 wt% hydrogel

(Mg ²⁺ , Ca ²⁺ , Fe ²⁺ , Fe ³⁺ , Al ³⁺ , and Cu ² O) were added to 0.75 mL of distilled water in a solution of 0.75 mL of distilled water and 0.5 g of 17R4- ⁺ , Zn ²⁺ ; 2 eq. Or 1.3 eq.) Was added thereto, followed by thorough mixing using a voltex mixer.

Measurement of sol-gel phase transition temperature

The phase transition temperature of the hydrogel was measured by increasing the temperature by 1 ° C by the vial tilt method.

?

Measurement result

1. Changes due to changes in pH

The pH of the polymer itself was controlled by the amount of sodium hydroxide (NaOH) in the hydrogel prepared in Preparation Example 1, and the change of the sol-gel phase transition temperature was investigated. The results are shown in Table 2 and FIG. As shown in the results, only the polymer having pH 6.0 or higher was able to form a gel, and the polymer having pH 5.5 to pH 5.9 did not form a gel. At the same concentration, the sol - gel phase transition temperature tended to decrease as the pH of the polymer increased. However, when the polymer had a pH value of 13.0 or higher, the phase transition temperature was rapidly increased.

2. Changes due to calcium ion addition

The amount of calcium ion was varied in the hydrogel prepared in Preparation Example 1 to prepare a sol-gel phase transition

I examined the temperature change. 0.5 to 2.0 equivalents of calcium chloride, which provides calcium ions, was added, and the pH of the resulting polymer did not change greatly. When 0.5 equivalent of calcium chloride was added at the same concentration, the gel was not formed and the gel was formed from 1.0 equivalent or more of calcium chloride. The phase transition temperature was increased by 10 ° C or more as compared with the polymer added with 1.5 and 2.0 equivalents of calcium chloride, The width of the phase separation temperature was greatly narrowed (Table 3 and Fig. 3).

3. Changes due to multivalent metal cations

The polyvalent metal cation was changed in the hydrogel prepared in Preparation Example 1 to prepare a sol-

The gel phase transition temperature was measured. The salts containing polyvalent metal cations include calcium chloride (CaCl ₂ ), zinc chloride (ZnCl ₂ ), magnesium chloride (MgCl ₂ ), copper chloride (CuCl ₂ ), iron chloride (II) (FeCl ₂ ) FeCl ₃ ) and aluminum chloride (AlCl ₃ ) were used. The sol - gel phase transition temperature and phase separation temperature were controlled by the concentration of the polymer in each polyvalent metal cation. The sol - gel phase transition temperature, phase separation temperature, and critical concentration Of the patients. Calcium ion (Ca ²⁺ ) was added as a multivalent metal cation, and the critical concentration for gel formation could be controlled to 1 wt%.

4. Changes due to additives

Sodium chloride, calcium chloride, sodium thiocyanate, and the like are added to a 25 wt%

And the polymers such as salts and PEG were added in an amount of 2 wt% or more and 10 wt% or less, respectively, to measure the sol-gel phase transition temperature and elastic modulus. The results are shown in FIG. It was found that sodium thiocyanate and PEG increased the sol - gel phase transition temperature as the concentration of polymer increased, whereas sodium chloride and calcium chloride decreased the sol - gel phase transition temperature as the concentration of polymer increased.

5. Changes due to aging time

25 wt% Ca ₂ (17R4-BDHP) hydrogel was prepared and aged in a constant temperature water bath at 37 ° C., and the change in sol-gel phase transition temperature with aging time was measured. The results are shown in Table 4 and FIG. The phase transition temperature decreased as the aging time of 25 wt% Ca ₂ (17R4-BDHP) at 29 ° C was longer and the sol-gel phase transition at 24 ° C was observed at 4.5 ° C.

Manufacture of mask pack

Using the hydrogel prepared in Preparation Example 1, the natural extract components were mixed and applied to a nonwoven mask pack support to prepare a mask pack. It was confirmed that the mask pack thus prepared was applied to the face skin, and a film was formed on the lower part of the mask pack support after about 30 minutes elapsed. This indicates that the hydrogel according to the present invention, which was in a sol state, after the skin active ingredient was first adhered to the skin, undergoes phase transition to a gel state at a body temperature range to form a thin film on the surface, It is possible to prevent evaporation.

Claims (12)

A hydrophilic polymer or an amphipathic polymer containing two or more phosphate groups on a mask pack support and a polyvalent cation corresponding to the negative charge of the phosphate group and then aging, and is prepared by aging in a gel state at a temperature range of 10 to 50 캜 And a temperature responsive sol-gel transition hydrate gel containing a skin active component.
The method according to claim 1, comprising 1 to 30% by weight of the thermosensitive sol-gel transition gel, 1 to 20% by weight of a skin active ingredient, 1 to 30% by weight of additives and residual water on a mask pack support Mask pack using temperature sensitive sol - gel transition hydrogel.
[5] The method of claim 1, wherein the hydrophilic polymer is selected from the group consisting of polyethyleneglycol (PEG), poly N-isopropylacrylamide (PNIPAM), polymethylacrylate (PMA), polymethylmetacrylate Polyacrylamide, polyacrylic acid (PAA), polymethacrylic acid (PMAA), polyvinylpyrrolidone (PVP), polyethylene oxide (PEO), polyvinyl alcohol Block, graft, or dendrimer hydrophilic polymer comprising a polymer selected from the group consisting of polyvinyl alcohol (PVA), methyl cellulose, collagen, alginate, chitosan, and combinations thereof Wherein the temperature-sensitive sol-gel transition hydrate gel is used.
The method of claim 1, wherein the amphiphilic polymer is selected from the group consisting of polyethyleneglycol (PEG), poly N-isopropylacrylamide (PNIPAM), polymethylacrylate (PMA), polymethylmetacrylate (PMMA), polyacrylamide, polyacrylic acid (PAA), polymethacrylic acid (PMAA), polyvinylpyrrolidone (PVP), polyvinyl alcohol Block, graft or dendrimer hydrophilic polymer block comprising a polymer selected from the group consisting of methyl cellulose, polyethylene oxide (PEO), collagen, alginate, chitosan, and combinations thereof. ; And polypropylene oxide (PPO), polylactic acid (PLA), poly lactide-coglycolide (PLGA), polycaprolactone, polyvinylacetate (PVAc) Block, graft, or dendrimer hydrophobic polymer block comprising at least one selected from the group consisting of a polymer, a polypeptide, and a combination thereof.
[3] The method of claim 1, wherein the polyvalent cation is a metal cation having a valence of +2 or more; A low molecular weight or high molecular weight cation comprising at least two cations selected from -NH ₃ ⁺ , -N ⁺ H ₂ (CH ₃ ), -N ⁺ H (CH ₃ ) ₂ and -N ⁺ (CH ₃ ) ₃ ; And a combination thereof. ≪ RTI ID = 0.0 > 21. < / RTI >
[6] The method according to claim 5, wherein the +2-valent metal cation is selected from the group consisting of Mg ²⁺ , Ca ²⁺ , Fe ²⁺ , Fe ³⁺ , Al ³⁺ , Cu ²⁺ , Zn ²⁺ , Wherein the temperature-sensitive sol-gel-transferred hydrogel is used as a mask.
The composition according to claim 1, wherein the skin active ingredient is selected from the group consisting of aloe, green tea, ginseng, wood vinegar, pine needles, propolis, ginkgo leaf, silkworm, mulberry leaf, And a natural extract component extracted from at least one natural product selected from the group consisting of licorice; and a temperature responsive sol-gel transfer hydrate gel.
The mask pack according to claim 2, wherein the additive is at least one selected from a skin affinity enhancer, a polyhydric alcohol, a gel stabilizer, and a phase transition temperature regulator.
[Claim 9] The mask pack according to claim 8, wherein the skin affinity enhancer is selected from chitosan, porphyoglycan, chitosan derivatives, elastin, collagen, and hyaruronic acid.
[Claim 9] The mask pack according to claim 8, wherein the polyhydric alcohol is selected from propylene glycol and glycerin.
The mask pack according to claim 8, wherein the gel-stabilizing agent is selected from methylparaben, propylparaben, kojic acid, -hydroxy acid, imidazolidinyl urea and retinol.
The method according to claim 8, wherein the phase change temperature controlling agent is temperature sensitive, characterized in that the sol is selected from NaCl, CaCl _2, NaCSN, PEG - gel transition mask pack using the hydrogels.

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