KR101582822B1 - Fluid injection device for skin irritation - Google Patents

Abstract

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fluid injecting apparatus for skin irritation and, more particularly, to a fluid injecting apparatus for skin irritation which allows an immunologically active drug such as a therapeutic agent or a vaccine or a skin- .
According to the present invention, since a fluid injecting device for skin irritation, which is made up of an opening / closing rod, an opening and closing member, and an elastic member, the fluid transmitting means is relatively simple in structure and easy in operation and low in manufacturing cost, The opening and closing of the fluid reservoir having the diameter is relatively opened and closed but the supply and blocking of the fluid supplied from the fluid reservoir is relatively easy since the fluid reservoir is coupled to open and close the fluid path formed in the relatively small micro needle housing as compared with the inlet of the fluid reservoir. One effect can be obtained.

Description

[0001] FLUID INJECTION DEVICE FOR SKIN IRRITATION [0002]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a fluid injecting apparatus for skin irritation and, more particularly, to a fluid injecting apparatus for skin irritation which allows an immunologically active drug such as a therapeutic agent or a vaccine or a skin- .

In general, oral administration methods or injecting administration methods are used to inject immunosuppressive drugs such as therapeutic agents or vaccines or skin-elasticity drugs for skin care into the body. However, in the oral administration method, various drugs are not directly absorbed into the blood stream due to the action of digestive enzymes in the gastrointestinal tract, etc., and they do not exhibit full efficacy. Injection administration method is such that various drugs are injected into the bloodstream through the skin or vein It can be injected into the bloodstream without being deformed by digestive enzymes. However, since the needle penetrates into the dermal layer of the skin during injection, it may cause pain and pathogenic infection.

In order to overcome such disadvantages of the oral administration method or the injection administration method, recently, a transdermal administration method in which various drugs are administered through the skin into a local tissue or systemic circulation system has been proposed. The transdermal administration method is a method of administration using a microneedle device. In the microneedle device, the microneedles act to pierce the skin layer including the stratum corneum of the skin physically without causing pain when the drug is administered. Accordingly, when the drug is administered to the micro needle device, the skin layer is penetrated through the plurality of micro-needles, and the drug delivered to the dermal layer of the skin is improved in speed.

An example of a micro needle device according to the prior art is disclosed in Korean Patent No. 10-1032298 (Registered on Apr. 25, 2011), Korean Patent No. 10-1017392 (Registered on Feb. 17, 2011) 10-0972800 (registered on July 22, 2010).

Prior art microneedle devices including the above prior arts include a fluid storage for storing various medicines, a plurality of microneedles arranged to protrude outwardly, a medicine stored in the fluid storage part, And the medicine stored in the fluid reservoir is transmitted to the dermal layer of the skin along the micro needle, when the micro needle is brought into contact with the skin, And is configured to rapidly transfer the drug stored in the fluid storage portion to the dermal layer of the skin through the micro needles.

However, the prior art microneedle devices including the above-mentioned prior arts are relatively inconvenient to operate the opening / closing means for transferring the drug stored in the fluid storage portion to the plurality of micro needles, or the structure of the transfer means is complicated, can do.

Korean Patent Registration No. 10-0972800 discloses a fluid selection means for selectively supplying a fluid stored in a fluid storage portion. Since the user must directly operate the fluid selection means to supply the fluid stored in the fluid storage portion, It can be inconvenient.

Korean Patent No. 10-1032298 discloses a medical device which includes a blocking rod exposed frontward to open a fluid reservoir through the blocking rod when the micro needles come in contact with the skin so that the drug stored in the fluid reservoir is supplied to the micro needles The user can easily supply the drug stored in the fluid storage unit to the micro needles without any operation. However, since the open / close structure using the shut-off bar is somewhat complicated, there is a problem that the manufacturing cost of the micro needle device is increased have.

In addition, in the prior art micro needle devices including the aforementioned prior arts, the drug stored in the fluid storage portion is administered to the dermal layer of the skin along the surface of the micro needles inserted into the skin. At this time, The surface of the needles is pressed so that the drug delivered along the surface of the micro needles can not be delivered to the dermal layer of the skin due to the elasticity of the skin and the drug delivered to the dermal layer of the skin also flows backward The micro-needles were discharged to the outside and the effect of administering the drug was practically insignificant.

KR 10-1032298 B1, 2011. 04.25. KR 10-1017392 B1, 2011. 02. 17. KR 10-0972800 B1, 2010. 07. 22. KR 10-1080034 B1, Oct. 31, 2011.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made in order to solve the problems of the prior art, and it is an object of the present invention to provide a fluid injecting apparatus for skin irritation which is simple in structure and operation, easy to use, The purpose is to provide.

According to one aspect of the present invention, there is provided a medical device comprising: a fluid reservoir in which a fluid containing a drug to be administered to a skin is stored; A plurality of coupling grooves for coupling the head portions of the plurality of microneedles are formed in one side portion and a first coupling groove portion in which the upper portion of the fluid reservoir is inserted and coupled into the other side portion, A microneedle housing having a plurality of fluid passages formed therein to supply fluid stored in the fluid reservoir to the microneedles; A plurality of fluid discharge holes are formed at one side of the micro needle housing so as to penetrate the insertion portions of the micro needles and are exposed to the outside and are formed at one side of the micro needle housing at the other side, A second concave portion communicating with the fluid discharge holes so as to face the first concave portion communicating with the fluid passage is formed so as to form a fluid chamber together with the first concave portion so that the fluid introduced from the fluid passage is temporarily accommodated An upper cap for transferring the fluid to the fluid discharge holes; A first hollow formed in a first concave portion of the microneedle housing and a second hollow formed in a central portion of a second concave portion of the upper cap in alignment with the first hollow and connected at one end to the outside of the upper cap An opening / closing member for opening and closing the fluid passage, one side of which is coupled to the other end of the opening / closing rod, the other side of which is inserted into the fluid reservoir and moves up and down in conjunction with the opening / And an elastic member provided inside the first and second hollows to surround the outer surface and elastically supporting the opening and closing rod inside the first and second hollows, A fluid injection device for a fluid is provided.

Preferably, the insertion portion of the microneedle is formed with a threaded or helical fluid discharge groove continuously connected to the outer circumferential surface.

Preferably, the insertion portion of the microneedle further includes a hollow formed at a center of the end portion at a predetermined depth, and a communication hole connecting the hollow and the fluid discharge groove.

Preferably, the opening / closing member has a circular structure at one side corresponding to the inner circumferential surface of the first engaging groove, and has an outside diameter smaller than the inside diameter of the first engaging groove so that the outer circumferential surface is not in close contact with the inner circumferential surface of the first engaging groove, As shown in FIG.

Preferably, the stationary ring is coupled to the second hollow so as to surround the outer circumferential surface of the open / close rod to block the fluid from flowing into the second hollow along the surface of the open / close rod when the open / close rod moves up and down .

As described above, according to the present invention, since a fluid injecting device for skin irritation, which comprises an opening / closing rod, an opening and closing member, and an elastic member, is provided with a fluid transmitting means, the structure is relatively simple, The opening and closing member is not opened or closed at the inlet of the fluid reservoir having a relatively large diameter but is connected to open and close the fluid passage formed in the relatively small microneedle housing relative to the inlet of the fluid reservoir, It is possible to obtain an effect that supply and shut-off is relatively easy.

According to the present invention, since the fluid discharge groove is formed on the outer circumferential surface of the insertion portion of the microneedle, the fluid discharge groove is formed so that even when the surface is pressed by the elastic force of the skin when the insertion portion is inserted through the skin, The fluid to be delivered into the skin along the fluid discharge groove is supplied to the skin along the fluid discharge groove without being affected by elasticity of the skin, thereby minimizing the loss of the fluid and improving the dose of the drug.

According to the present invention, a hollow is formed in the central portion of the insertion portion of the micro needle, and fluid communicated along the fluid discharge groove by communicating the fluid discharge groove and the hollow through the communication hole is discharged from the end portion of the insertion portion And the medicament is delivered through the hollow through the hollow and then through the hollow to the skin, thereby minimizing the effect of skin elasticity, thereby improving the dose of the drug.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an assembled perspective view illustrating a fluid injection device for skin irritation according to an embodiment of the present invention; FIG.
Fig. 2 is a view showing a state in which the main body and the protective cap shown in Fig. 1 are separated. Fig.
3 is an exploded perspective view of the main body shown in Fig.
4 is a cross-sectional view of the body shown in Fig.
5 is an enlarged view of the microneedles shown in Fig.
6 is an enlarged cross-sectional view of an insertion portion of a micro needle according to another embodiment of the present invention;
FIG. 7 is a cross-sectional view illustrating an operation characteristic of a fluid injector for skin stimulation according to an embodiment of the present invention; FIG.
8 is a cross-sectional view showing a path through which fluid is administered to the skin.

BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention, and how to accomplish them, will become apparent by reference to the embodiments described in detail below with reference to the accompanying drawings. However, the present invention is not limited to the embodiments described below, but may be embodied in various other forms.

The present embodiments are provided so that the disclosure of the present invention is thoroughly disclosed and that those skilled in the art will fully understand the scope of the present invention. And the present invention is only defined by the scope of the claims. Thus, in some embodiments, well known components, well known operations, and well-known techniques are not specifically described to avoid an undesirable interpretation of the present invention.

Like reference numerals refer to like elements throughout the specification. Moreover, terms used herein (to be referred to) are intended to illustrate the embodiments and are not intended to limit the invention. In the present specification, the singular form includes plural forms unless otherwise specified in the specification. Also, components and acts referred to as " comprising (or comprising) " do not exclude the presence or addition of one or more other components and operations.

Unless defined otherwise, all terms (including technical and scientific terms) used herein may be used in a sense commonly understood by one of ordinary skill in the art to which this invention belongs. Also, commonly used predefined terms are not ideally or excessively interpreted unless they are defined.

The term 'fluid' as used throughout the specification refers to a liquid or gel-like substance which is easy to deform and has a flowing property and an undefined shape. In the present invention, an immunologically active drug such as a therapeutic agent or a vaccine, And all drugs that can be administered to the skin for skin treatment and cosmetics, such as drugs.

Hereinafter, the technical features of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 is a perspective view showing an assembly of a fluid injector for skin irritation according to an embodiment of the present invention, FIG. 2 is a view showing a state where the body and the protective cap shown in FIG. 1 are separated, Fig. 4 is a cross-sectional view of the main body shown in Fig. 2. Fig.

1 to 4, a device 1 for injecting a fluid for skin stimulation according to an embodiment of the present invention includes a main body 10 and a protective cap 20 covering and protecting the top of the main body 10 .

The body 10 includes a fluid reservoir 11, a microneedle housing 12, a plurality of microneedles 13, an upper cap 14 and a fluid delivery means 15, as shown in Figs.

As shown in FIGS. 3 and 4, the fluid reservoir 11 is formed in a cylindrical shape so as to receive and store the fluid. One side of the fluid reservoir 11 having the inlet is inserted into the first coupling groove 121 of the microneedle housing 12, do. The fluid reservoir 11 has a multi-divided structure partitioned independently of each other to accommodate a variety of different drugs at the same time.

3 and 4, the microneedle housing 12 is provided with a plurality of coupling grooves 122 to which a plurality of microneedles 13 are coupled at one side (an upper side in the drawing), and the other side The fluid stored in the fluid reservoir 11 is passed through the microneedles 13 from the one side to the other side of the first fluid channel 11, A plurality of fluid passages 123 are provided. A first recess 124 communicating with the fluid passage 123 is formed at one side.

In the present invention, it is preferable that the fluid passage 123 is formed in a rectangular or bar shape so that a large amount of fluid supplied from the fluid reservoir 11 is transmitted to the first concave portion 124.

5 is an enlarged view of the microneedles shown in FIG.

3 to 5, the microneedle 13 includes a head part 131 inserted and coupled to the coupling groove 122 of the microneedle housing 12, an insertion part inserted into the skin through the skin And a connecting portion 133 connecting the head portion 131 and the inserting portion 132.

The head portion 131 is larger than the insertion portion 132 and the connection portion 133 in order to stably connect the microneedles 13 to the microneedle housing 12 while preventing the microneedles 13 from being broken easily. Diameter. The head 131 may be coupled to the coupling groove 122 of the microneedle housing 12 by bonding, gluing, press fitting, or screw fastening.

The insert 132 penetrates the skin and forms a pore in the skin to allow the fluid to penetrate into the skin. In order to minimize the pain when inserted into the skin, the insertion portion 132 is preferably formed to have an outer diameter within a range of about 1 to 100 mu m, and the insertion portion 132 is cut at an angle of about 25 to 45 degrees toward the end portion, .

Further, in order to prevent the fluid, which is pressurized by the elastic force of the skin and transmitted along the surface, from being transmitted to the dermal layer of the skin when the fluid is applied to the dermal layer of the skin along the surface, A fluid discharge groove 132-1 having a threaded or helical shape continuously connected from one end to the other end may be formed.

That is, since the fluid discharge groove 132-1 is formed in the outer peripheral surface of the insertion portion 132, the surface of the insertion portion 132 is pressed by the elastic force of the skin when the insertion portion 132 is inserted through the skin The fluid delivered to the skin along the fluid discharge groove 132-1 due to the step with the skin is supplied to the skin along the fluid discharge groove 132-1 without being affected by the elasticity of the skin, The dose can be improved by minimizing the loss.

6 is an enlarged cross-sectional view of an insertion portion of a micro needle according to another embodiment of the present invention.

6, the insertion portion 132 'of the microneedle according to another example of the present invention includes a fluid discharge groove 132-1' and a hollow 132-2 'formed at a predetermined depth in the center of the end portion. And a communication hole 132-3 'for communicating the hollow 132-2' and the fluid discharge groove 132-1 '.

As shown in FIG. 5, when the insertion portion 132 is inserted through the skin, the fluid transferred to the skin along the fluid discharge groove 132-1 due to the step difference with the skin is not affected by elasticity of the skin, And is transmitted to the skin along the groove 132-1, thereby minimizing the loss of fluid.

However, since the insertion portion 132 is formed to have a relatively small outer diameter in order to minimize the pain, it is practically impossible to form the fluid discharge groove 132-1 deep on the outer peripheral surface thereof. Accordingly, depending on the degree of elasticity of the skin, the skin may affect the fluid delivered along the fluid discharge groove 132-1. Particularly, since elasticity of the skin becomes greater toward the dermal layer than the skin layer, the fluid discharge groove 132-1 alone has a limitation in preventing fluid loss.

Therefore, in the other example of the present invention, the hollow 132-2 'is formed at a predetermined depth in the center of the insertion part 132', and the fluid discharge groove 132-1 ' Fluid communicated along the fluid discharge groove 132-1 'by mutually communicating the hollow 132-2' is discharged from the end portion of the insertion portion 132 'through the communication hole 132-3' To the skin 132-2 'and then to the skin through the hollow 132-2', thereby minimizing the effect of skin elasticity.

3 and 4, the upper cap 14 is coupled through the bolt B to cover one side of the microneedle housing 12. A plurality of fluid discharge holes 141 are formed at one side of the upper cap 14 to penetrate the insertion portion 132 of the microneedles 13 and exposed to the outside, and a microneedle housing 12, A second concave portion 142 communicating with the fluid discharge holes 141 is formed so as to face the first concave portion 124 of the first concave portion 124 to form a fluid chamber together with the first concave portion 124, And transfers it to the fluid discharge hole 141.

3 and 4, the fluid delivery means 15 includes a first hollow 125 formed at the center of the first recess 124 of the microneedle housing 12 and a second hollow 125 aligned with the first hollow 125 An opening / closing rod 151 penetrating through the second hollow 143 formed at the center of the second concave portion 142 of the upper cap 14 and having one end protruding outward of the upper cap 14, An opening and closing member 152 which is coupled to the other end of the rod 151 and whose other side is inserted into the fluid reservoir 11 to move up and down in conjunction with the movement of the opening and closing rod 151 to open and close the fluid passage 123, And the opening and closing rod 151 is installed inside the first and second hollows 125 and 143 so as to enclose the outer surface of the opening and closing rod 151. The opening and closing rod 151 is inserted into the first and second hollows 125 and 143, And an elastic member 153 for supporting the elastic member 153.

The fluid transmission means 15 may further include an engaging member 154 that engages the other side of the opening and closing rod 151 by inserting the other side of the opening and closing rod 151 into the engaging groove 152-1 provided at the center of one side of the opening and closing member 152 have. At this time, the other side of the opening / closing rod 151 is inserted into the inside through the one side of the engaging member 154. The engaging member 154 has a cylindrical shape and an engaging groove 154-1 is formed on an outer circumferential surface of the engaging member 154 so that the engaging protrusion provided inside the engaging groove 152-1 of the opening and closing member 152 can be engaged.

3, the opening / closing member 152 has a circular shape at one side in correspondence with the inner circumferential surface of the first engaging groove 121, and has an outer diameter larger than the first diameter so that the outer circumferential surface does not come into close contact with the inner circumferential surface of the first engaging / Is smaller than the inner diameter of the coupling groove 121. The fluid stored in the fluid reservoir 11 is separated from the first engagement groove 121 by the opening and closing member 152 when the opening and closing member 152 is separated from the fluid passage 123 to open the fluid passage 123, And the outer circumferential surface of the opening and closing member 152. The fluid passage 123 is provided with a through-hole (not shown).

On one side of the opening / closing member 152 in contact with the fluid passage 123, a rubber pad having excellent adhesion is preferably attached to stably seal the fluid passage 123.

The fluid injecting apparatus 1 for skin irritation according to the present invention is relatively simple in structure since the fluid transmitting means 15 is composed of the opening and closing rod 151, the opening and closing member 152 and the elastic member 153, The opening and closing member 152 does not open or close the inlet of the fluid reservoir 11 having a relatively large diameter but opens the fluid passage 123 formed in the microneedle housing 12 relatively smaller than the inlet of the fluid reservoir 11 It is possible to obtain an advantage that the fluid supplied from the fluid reservoir 11 can be supplied and blocked relatively easily.

Meanwhile, a fixing ring (not shown) may be further coupled to the second hollow 125 of the micro needle housing 12 to surround the outer circumferential surface of the opening and closing rod 151. At this time, the fixing ring may be fixed to the outer circumferential surface of the opening and closing rod 151. In order to prevent the fluid from flowing into the second hollow 125 along the surface of the opening and closing rod 151 during the vertical movement of the opening and closing rod 151 . Such a fixing ring may have a constant elasticity and be made of a harmless silicon material.

FIG. 7 is a cross-sectional view illustrating an operation of a fluid injector for skin stimulation according to an embodiment of the present invention, and FIG. 8 is a cross-sectional view illustrating a path through which fluid is administered to the skin.

7 (a), when the opening and closing member 152 of the fluid transmitting means 15 is brought into close contact with the fluid passage 123 and the fluid passage 123 is closed, as shown in FIG. 7 (b) Closing member 151 moves downward in association with the opening / closing rod 151 when the opening / closing member 151 moves downward in the drawing due to a force applied after the contact with the skin 3, , The fluid passage 123 is opened and connected to the fluid reservoir 11, the first engagement groove 121, the fluid passage 123, the first and second recesses 124 and 142, and the fluid discharge hole 141 A fluid path is formed. The fluid 2 stored in the fluid reservoir 11 flows through the first engagement groove 121, the fluid passage 123, the first and second recesses 124 and 142, and the fluid discharge hole 141 Is transferred to the micro needle 13 and then into the skin 3 along the fluid discharge groove 132-1 of the insertion part 132. [

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

1: fluid injection device for skin irritation
2: Fluid
3: Skin
10: Body
20: Protective cap
11: fluid reservoir
12: Micro needle housing
13: Micro needle
131:
132, 132 ': insertion portion
132-1, 132-1 ': fluid discharge groove
132-2 ': hollow
132-3 ': communicating ball
133: Connection
14: upper cap
15: fluid delivery means
151: opening / closing rod
152:
153: elastic member
154:

Claims (5)

A fluid reservoir in which a fluid containing a drug to be administered to the skin is stored;
A plurality of coupling grooves for coupling the head portions of the plurality of microneedles are formed in one side portion and a first coupling groove portion in which the upper portion of the fluid reservoir is inserted and coupled into the other side portion, A microneedle housing having a plurality of fluid passages formed therein to supply fluid stored in the fluid reservoir to the microneedles;
A plurality of fluid discharge holes are formed at one side of the micro needle housing so as to penetrate the insertion portions of the micro needles and are exposed to the outside and are formed at one side of the micro needle housing at the other side, A second concave portion communicating with the fluid discharge holes so as to face the first concave portion communicating with the fluid passage is formed so as to form a fluid chamber together with the first concave portion so that the fluid introduced from the fluid passage is temporarily accommodated An upper cap for transferring the fluid to the fluid discharge holes; And
A first hollow formed in a first concave portion of the microneedle housing and a second hollow formed in a central portion of a second concave portion of the upper cap in alignment with the first hollow and connected at one end to the outside of the upper cap An opening / closing member for opening and closing the fluid passage, one side of which is coupled to the other end of the opening / closing rod, the other side of which is inserted into the fluid reservoir and moves up and down in conjunction with the opening / An elastic member provided inside the first and second hollows to surround the outer surface and elastically supporting the opening / closing rod inside the first and second hollows, and a second side portion of the opening / And a coupling member which is inserted into and engaged with the coupling groove provided in the coupling member. ≪ / RTI >
Wherein the inserting portion of the microneedle is provided with a threaded or helical fluid discharge groove continuously connected to the outer circumferential surface, a hollow formed at a predetermined depth in the center of the end portion, and a hollow formed in the fluid discharge groove, A communicating hole is formed,
Wherein the fluid passage is formed in a rectangular or bar shape so that a large amount of fluid supplied from the fluid reservoir is transmitted to the first concave portion,
Wherein the opening and closing member has a circular shape at one side in correspondence with the inner circumferential surface of the first engaging groove and has an outer diameter smaller than the inner diameter of the first engaging groove so that the outer circumferential surface is not in close contact with the inner circumferential surface of the first engaging groove, Wherein the fluid stored in the fluid reservoir is discharged through the gap between the inner circumferential surface of the first engaging groove and the outer circumferential surface of the opening and closing member when the opening and closing member interlocks with the opening and closing rod and is separated from the fluid passage, Is transferred to the fluid passage,
And a fixing ring is coupled to the second hollow to enclose the outer circumferential surface of the opening and closing rod so that the fluid is prevented from flowing into the second hollow along the surface of the opening and closing rod when the opening and closing rod moves up and down.
And the fluid is injected into the skin. delete delete delete delete

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