KR102722950B1 - 수포성 표피박리증의 치료를 위한 방법 및 조성물 - Google Patents

수포성 표피박리증의 치료를 위한 방법 및 조성물 Download PDF

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KR102722950B1
KR102722950B1 KR1020207010214A KR20207010214A KR102722950B1 KR 102722950 B1 KR102722950 B1 KR 102722950B1 KR 1020207010214 A KR1020207010214 A KR 1020207010214A KR 20207010214 A KR20207010214 A KR 20207010214A KR 102722950 B1 KR102722950 B1 KR 102722950B1
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microvesicles
cells
delete delete
isolated
pharmaceutical composition
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Korean (ko)
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KR20200088799A (ko
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에반젤로스 브이. 바디아바스
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더 유니버시티 오브 마이애미
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Priority claimed from US15/712,294 external-priority patent/US12558316B2/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Water Treatments (AREA)
  • Medicinal Preparation (AREA)
KR1020207010214A 2017-09-22 2018-09-21 수포성 표피박리증의 치료를 위한 방법 및 조성물 Active KR102722950B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/712,294 2017-09-22
US15/712,294 US12558316B2 (en) 2013-03-13 2017-09-22 Methods and compositions for the treatment of epidermolysis bullosa
PCT/US2018/052213 WO2019060719A1 (en) 2017-09-22 2018-09-21 METHODS AND COMPOSITIONS FOR THE TREATMENT OF BULLETIN EPIDERMOLYSIS

Publications (2)

Publication Number Publication Date
KR20200088799A KR20200088799A (ko) 2020-07-23
KR102722950B1 true KR102722950B1 (ko) 2024-10-28

Family

ID=65810503

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207010214A Active KR102722950B1 (ko) 2017-09-22 2018-09-21 수포성 표피박리증의 치료를 위한 방법 및 조성물

Country Status (10)

Country Link
EP (1) EP3684336A4 (de)
JP (1) JP7525396B2 (de)
KR (1) KR102722950B1 (de)
CN (1) CN111182890A (de)
AU (1) AU2018335788B2 (de)
CA (1) CA3076610A1 (de)
EA (1) EA202090814A1 (de)
IL (1) IL273407B2 (de)
MX (2) MX2020002777A (de)
WO (1) WO2019060719A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
WO2014159662A1 (en) 2013-03-13 2014-10-02 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US12558316B2 (en) 2013-03-13 2026-02-24 University Of Miami Methods and compositions for the treatment of epidermolysis bullosa
IL322149A (en) * 2019-05-03 2025-09-01 Cellphire Inc Materials and methods for manufacturing blood products
KR102125567B1 (ko) 2019-07-02 2020-06-22 한양대학교 에리카산학협력단 식물 엑소좀의 대량 생산 방법
AU2020459825A1 (en) * 2020-07-22 2023-03-16 Osaka University Therapeutic agent for dystrophic epidermolysis bullosa
AU2021327376A1 (en) * 2020-08-21 2023-04-20 University Of Miami Compositions and methods of treatment using microvesicles from bone marrow-derived mesenchymal stem cells
EP3971440B1 (de) 2020-09-21 2023-12-27 Brembo S.p.A. Bremsband einer scheibenbremsscheibe sowie scheibenbremsscheibe
CA3217654A1 (en) * 2021-04-23 2022-10-27 Spot Biosystems Ltd. Extracellular vesicles loaded with biomolecules
JP2024531238A (ja) * 2021-08-12 2024-08-29 オンコノヴァ セラピューティクス， インコーポレイテッド がんを処置するための方法および組成物
US12589120B2 (en) 2021-10-12 2026-03-31 Eliksa Therapeutics, Inc. Methods of treating epidermolysis bullosa with cell-free amniotic fluid compositions
EP4694903A1 (de) * 2023-04-11 2026-02-18 Eliksa Therapeutics, Inc. Verfahren zur erhöhung des therapeutischen proteinspiegels und/oder zur verbesserung der zellfunktion mit fruchtwasserzusammensetzungen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518109A (ja) 2013-03-13 2016-06-23 ユニバーシティ・オブ・マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ 細胞培養上清および生体液からの微小胞の単離および精製のための方法
WO2017122095A1 (en) 2016-01-15 2017-07-20 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
US20170258845A1 (en) 2013-09-16 2017-09-14 Agency For Science, Technology And Research Methods of Treating Graft Versus Host Disease (GVHD) or Epidermolysis Bullosa (EB)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015138878A1 (en) * 2014-03-13 2015-09-17 Research Institute At Nationwide Children's Hospital, Inc. Methods of delivering heparin binding epidermal growth factor using stem cell generated exosomes
WO2016172598A1 (en) * 2015-04-22 2016-10-27 The Broad Institute Inc. Exosomes and uses thereof
US20190133922A1 (en) * 2016-01-12 2019-05-09 Kangstem Biotech Co., Ltd. Stem Cell-Derived Exosomes Containing a High Amount of Growth Factors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518109A (ja) 2013-03-13 2016-06-23 ユニバーシティ・オブ・マイアミＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍｉａｍｉ 細胞培養上清および生体液からの微小胞の単離および精製のための方法
US20160184363A1 (en) 2013-03-13 2016-06-30 University Of Miami Method for isolation and purification of microvesicles from cell culture supernatants and biological fluids
US20170258845A1 (en) 2013-09-16 2017-09-14 Agency For Science, Technology And Research Methods of Treating Graft Versus Host Disease (GVHD) or Epidermolysis Bullosa (EB)
JP2017526723A (ja) 2013-09-16 2017-09-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 移植片対宿主病（ｇｖｈｄ）または表皮水疱症（ｅｂ）のエキソソームによる治療方法
WO2017122095A1 (en) 2016-01-15 2017-07-20 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use

Also Published As

Publication number Publication date
AU2018335788B2 (en) 2024-08-15
CA3076610A1 (en) 2019-03-28
IL273407B2 (en) 2025-09-01
IL273407A (en) 2020-05-31
MX2020002777A (es) 2020-09-17
JP2020534344A (ja) 2020-11-26
MX2022015753A (es) 2023-01-19
CN111182890A (zh) 2020-05-19
EP3684336A4 (de) 2021-06-02
AU2018335788A1 (en) 2020-03-19
JP7525396B2 (ja) 2024-07-30
IL273407B1 (en) 2025-05-01
WO2019060719A1 (en) 2019-03-28
EA202090814A1 (ru) 2020-08-07
KR20200088799A (ko) 2020-07-23
EP3684336A1 (de) 2020-07-29

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