KR102785809B1 - 이중특이성 항체 및 이의 제조 및 사용 방법 - Google Patents

이중특이성 항체 및 이의 제조 및 사용 방법 Download PDF

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KR102785809B1
KR102785809B1 KR1020207009543A KR20207009543A KR102785809B1 KR 102785809 B1 KR102785809 B1 KR 102785809B1 KR 1020207009543 A KR1020207009543 A KR 1020207009543A KR 20207009543 A KR20207009543 A KR 20207009543A KR 102785809 B1 KR102785809 B1 KR 102785809B1
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카트리나 비코바
빌 브래이디
블레어 렌쇼
동 시아
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브라이언 코바세비치
조나단 케이. 팰론
필 탄
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시스트이뮨, 인코포레이티드
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Abstract

본 개시 내용은 적어도 2개의 인간 CTLA4, PD-1 또는 PD-L1에 대한 결합 특이성을 갖는 이중특이성 항체를 제공한다. 한 실시양태에서, 이중특이성 항체는 중쇄 및 경쇄를 갖는 IgG 도메인, 및 중쇄의 C-말단 또는 경쇄의 N-말단에 연결되어있는 2개의 scFv 성분을 포함하고, 여기서 IgG 도메인은 제1 항원에 대한 결합 특이성을 갖고, 여기서 scFv 성분은 제2 항원에 대한 결합 특이성을 가지며, 여기서 제1 항원 및 제2 항원은 상이하고 CTLA4, α-PD-1 및 α-PD-L1으로부터 독립적으로 선택된다.

Description

이중특이성 항체 및 이의 제조 및 사용 방법
관련 출원에 대한 상호 참조
본 출원은 2017년 11월 2일에 출원된, "이중특이성 항체 및 이의 제조 및 사용 방법"이라는 명칭의 미국 가특허 출원 제62580845호에 대한 이익을 주장하며, 이는 그 전문이 본원에 참조로 명확히 포함된다.
기술분야
본 개시내용은 일반적으로 생물학적 치료제의 기술 분야에 관한 것이며, 보다 특히 이중특이성 항체(bispecific antibody)를 제조하고 사용하는 방법에 관한 것이다. 모든 참고문헌은 그 전문이 본원에 포함된다.
암 세포는 면역감시(immunosurveillance)를 피하기 위한 다양한 전략을 개발한다. 특정 종양 항원의 부재 및 주 조직적합성 복합체(major histocompatibility complex; MHC) 분자의 발현 손실은 T 림프구에 의한 암 세포의 인식을 방해한다. 면역억제 종양 미세환경 또한 면역계에 의한 종양 세포의 감소된 인식에 기여한다. 종양 미세환경은 조절 T 세포, 골수 유래 억제 세포, 종양 관련 대식세포, 억제 B 세포, TGF-베타 또는 IL-10과 같은 종양 또는 기질 세포에 의해 생산되는 면역억제 사이토카인, 및 T 세포 기능을 조절하는 면역 체크포인트(checkpoint) 분자로 구성되어있는 면역억제 세포 집단에 의해 나타난다(문헌[Marshall HT et al., Front Oncol 2018, 8:315]).
환자 자신의 면역계를 관여(engaging)시키는 것이 정상 조직을 손상시키지 않으면서, 종양 성장 제어 및 종양 세포의 특이적인 제거에 효과적이라는 것이 밝혀졌다. 면역요법(immunotherapy)이 암 치료에 대해 추가적인 관점을 제공했다(문헌[Khalil DN et al., Adv Cancer Res 2015, 128:1-68]).
면역계의 다수의 조절인자(modulator)를 조합하는 것은 면역-종양학(immuno-oncology) 분야의 빠르게 발전하는 새로운 영역이다. 다수의 경로를 통해 종양 세포에 대한 면역 반응을 조절할 수 있는 새로운 치료제는 환자 반응률을 증가시키고 일부 경우에는 독성을 감소시킴으로써 암 환자에게 매우 유익할 수 있다.
면역계를 표적화하는 하나 이상의 단일클론 항체와의 조합 요법은 암의 치료에 있어서 단일 제제에 의한 치료보다 더 효력이 있다는 것이 밝혀졌다(문헌[Hellman MD et al., Adv Immunol 2016, 130: 251-77]). 증가된 효능 및 반응률 이외에, 조합 요법은 종종 단일 제제 치료보다 더 큰 독성을 가진다. 면역계를 조절하는 이중특이성 제제는 환자에게 덜 독성일 수 있고/있거나 더욱 강력할 수 있고, 동일한 특이성을 갖는 단일클론 항체의 조합으로 구성된 치료에 비해 추가적인 작용 기전을 갖는다.
요약
본 개시내용은 이중특이성 항체, 특히, IgG 성분을 포함하여 BiTE 분자의 빠른 클리어런스(clearance)를 극복하고, 환자의 면역 세포의 생체외 확장을 필요로하지 않는 오프-더-셀프(off-the-shelf) 요법으로서 CAR-T 세포 요법보다 이점을 갖는, 이중특이성 항체에 관한 것이다. 이중특이성 항체의 다른 이점은 2개의 체크포인트 수용체의 동시 관여에 의해 억제 종양 미세환경을 극복하는 향상된 능력이다.
본 개시내용의 이중특이성 항체는 다른 제제, 예를 들어 T-세포 관여항체(T-cell engager)와 조합할 수 있고, 그의 활성을 추가로 향상시킬 수 있다.
본 개시내용은 면역 및 종양 세포 상에 발현된 2개의 구별된 표적에 결합하는 이중특이성 항체에 관한 것이다. 두 표적 모두 체크포인트 항원일 수 있다. 한 실시양태에서, 두 표적 모두 면역 세포 상의 체크포인트 항원일 수 있다. 한 실시양태에서, 두 표적 모두 종양 세포 상의 체크포인트 항원일 수 있다. 한 실시양태에서, 하나의 표적은 면역 세포 상의 체크포인트 항원이고 다른 표적은 종양 세포 상의 체크포인트 항원이다. 한 실시양태에서, 체크포인트 항원은 PD-1, PD-L1 및 CTLA4로부터 선택될 수 있다. 한 실시양태에서, 표적은 PD-1, PD-L1 및 CTLA4의 임의의 조합을 포함할 수 있다.
본 개시내용은 이중특이성 제제의 조성물, 및 암 및 자가면역 결핍증의 치료를 위한 이의 치료적 용도를 추가로 제공한다.
한 실시양태에서, 본 출원은 IgG 중쇄 및 경쇄, 및 중쇄의 C 말단 또는 경쇄의 N 말단에 연결되어있는 2개의 scFv 성분을 포함하는 이중특이성 항체로서, 여기서 IgG는 제1 항원에 결합 특이성을 갖고, 여기서 scFv 성분은 제2 항원에 결합 특이성을 가지며, 여기서 제1 항원 및 제2 항원은 상이하고 α-CTLA4, α-PD-1, 및 α-PD-L1으로부터 독립적으로 선택되는, 이중특이성 항체를 개시한다.
한 실시양태에서, 이중특이성 항체는 중쇄의 C 말단에 연결되어있는 2개의 scFv 성분을 갖는다. 한 실시양태에서, 제1 항원은 α-CTLA4을 포함하고 제2 항원은 α-PD-1 또는 α-PD-L1을 포함한다. 다른 실시양태에서, 제1 항원은 α-PD-1 또는 α-PD-L1을 포함하고 제2 항원은 α-CTLA4를 포함한다.
한 실시양태에서, 이중특이성 항체는 경쇄의 N 말단에 연결되어있는 2개의 scFv 성분을 갖는다. 한 실시양태에서, 제1 항원은 α-PD-1 또는 α-PD-L1을 포함하고 제2 항원은 α-CTLA4를 포함한다. 다른 실시양태에서, 제1 항원은 α-CTLA4를 포함하고 제2 항원은 α-PD-1 또는 α-PD-L1을 포함한다.
한 실시양태에서, 이중특이성 항체는 단리된 단일클론 항체이다.
한 실시양태에서, 이중특이성 항체는 본원에 개시된 바와 같은 서열을 갖는 항원 펩타이드 서열을 포함한다. 한 실시양태에서, 이중특이성 항체는 개시된 아미노산 서열과 적어도 70%, 80%, 90%, 95%, 98%, 또는 99% 유사성(similarity)을 갖는 항원 펩타이드 서열을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 본원에 개시된 바와 같은 서열을 갖는 항원-결합 단편을 포함한다. 한 실시양태에서, 이중특이성 항체는 개시된 항체 서열과 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 지닌 서열을 갖는 항원-결합 단편을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 70nM, 50nM, 40nM, 30nM, 20nM, 10nM, 또는 5nM 이하의 Kd로 α-CTLA4, α-PD-1 또는 α-PD-L1에 대한 결합 친화성을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 70nM, 50nM, 40nM, 30nM, 20nM, 10nM, 또는 5nM 이하의 Kd로 α-CTLA4 및 α-PD-1에 대한 결합 친화성을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 70nM, 50nM, 40nM, 30nM, 20nM, 10nM, 또는 5nM 이하의 Kd로 α-CTLA4 및 α-PD-L1에 대한 결합 친화성을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 70nM, 50nM, 40nM, 30nM, 20nM, 10nM, 또는 5nM 이하의 Kd로 α-CTLA4, α-PD-1, 또는 α-PD-L1 중 2개에 대한 결합 친화성을 가질 수 있다.
한 실시양태에서, 이중특이성 항체는 α-CTLA4, α-PD-1, 또는 α-PD-L1에 대한 고 친화성 결합, PD-1에 대한 PD-L1의 결합 억제, T 세포 활성화 향상, 항체 반응을 자극하는 능력 및/또는 면억억제 세포, 예를 들어 T 조절 세포의 억제 기능을 역전시키는 능력으로부터 선택된 하나 이상의 기능적 특성(functional property)을 나타낼 수 있다.
한 실시양태에서, T-세포 활성화를 향상시키는 것은 T-세포 증식, IFN-γ 및/또는 IL-2 분비, 또는 이의 조합을 포함한다.
한 실시양태에서, 이중특이성 항체는 인간 프레임워크(framework) 영역을 포함한다.
한 실시양태에서, 이중특이성 항체는 인간화 항체, 키메라 항체(chimeric antibod), 또는 재조합 항체일 수 있다.
한 실시양태에서, 이중특이성 항체는 IgG1 불변 영역(constant region)을 포함하여 이중특이성 분자의 순환 반감기를 연장시킨다. 한 실시양태에서, 이중특이성 항체의 IgG1 불변 영역은 서열번호 136과 적어도 98% 유사성을 갖는 아미노산 서열을 포함한다.
한 실시양태에서, 본 출원은 기재된 또는 본원에 개시된 바와 같은 기재된 특성을 갖는 클론들로 구성된 군으로부터 선택된 단리된 이중특이성 항체를 개시한다.
한 실시양태에서, 본 출원은 본원에 개시된 바와 같은 서열로부터 선택된 아미노산 서열을 포함하는, 이중특이성 항체를 위한 IgG1 중쇄를 개시한다. 한 실시양태에서, IgG1 중쇄는 서열번호 02, 06, 08, 10, 12, 14, 16, 18, 20, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 72, 92, 96, 100, 104,108, 112, 116, 120, 124, 128, 또는 132와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 가질 수 있다.
한 실시양태에서, 본 출원은 이중특이성 항체를 위한 카파 경쇄를 개시한다. 한 실시양태에서, 카파 경쇄는 서열번호 04, 28, 32, 36, 40, 44, 48, 52, 56, 60, 및 64와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 가질 수 있다.
한 실시양태에서, 본 출원은 본원에 개시된 바와 같은 아미노산 서열을 포함하는, 이중특이성 항체를 위한 가변 경쇄를 개시한다. 한 실시양태에서, 가변 경쇄는 서열번호 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 또는 134와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 가질 수 있다.
한 실시양태에서, 본 출원은 본원에 개시된 바와 같은 아미노산 서열을 포함하는, 이중특이성 항체를 위한 가변 중쇄를 개시한다. 한 실시양태에서, 가변 중쇄는 서열번호 92, 96, 100, 104,108, 112, 116, 120, 124, 128, 또는 132와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 가질 수 있다.
한 실시양태에서, 본 출원은 본원에 개시된 IgG1 중쇄, 본원에 개시된 카파 경쇄, 본원에 개시된 가변 경쇄, 또는 본원에 개시된 가변 중쇄를 포함하는, 이중특이성 항체를 암호화하는 단리된 핵산을 개시한다. 한 실시양태에서, 본 출원은 서열번호 02, 06, 08, 10, 12, 14, 16, 18, 20, 22, 26, 30, 34, 38, 42, 46, 50, 54, 58, 62, 72, 92, 96, 100, 104,108, 112, 116, 120, 124, 128, 또는 132와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 갖는 IgG1 중쇄, 서열번호 04, 28, 32, 36, 40, 44, 48, 52, 56, 60, 및 64와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 갖는 카파 경쇄, 서열번호 94, 98, 102, 106, 110, 114, 118, 122, 126, 130, 또는 134와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 갖는 가변 경쇄, 또는 서열번호 92, 96, 100, 104, 108, 112, 116, 120, 124, 128, 또는 132와 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 아미노산 서열을 갖는 가변 중쇄를 포함하는, 이중특이성 항체를 암호화하는 단리된 핵산을 개시한다.
한 실시양태에서, 본 출원은 본원에 개시된 단리된 핵산을 포함하는 발현 벡터를 개시한다. 한 실시양태에서, 발현 벡터는 본원에 개시된 핵산 서열과 적어도 70%, 80%, 90%, 98%, 또는 99% 유사성을 갖는 서열을 갖는 단리된 핵산을 포함한다.
한 실시양태에서, 발현 벡터는 세포 내에서 발현가능하다.
한 실시양태에서, 본 출원은 본원에 개시된 핵산을 포함하는 숙주 세포를 개시한다.
한 실시양태에서, 본 출원은 발현 벡터를 포함하는 숙주 세포를 개시한다.
한 실시양태에서, 본 출원은 숙주 세포를 개시하고, 여기서 숙주 세포는 원핵 세포 또는 진핵 세포이다.
일부 실시양태에서, 본 출원은 항체가 생산되도록 이의 제공된 숙주 세포를 배양하는 단계를 포함하는 항체를 생산하는 방법을 개시한다.
일부 실시양태에서, 본 출원은 이중특이성 항체 및 세포독성제(cytotoxic agent)를 포함하는 면역접합체(immunoconjugate)를 개시한다. 일부 실시양태에서, 세포 독성제는 화학치료제, 성장 억제제, 독소, 또는 방사성 동위원소이다.
한 실시양태에서, 본 출원은 이중특이성 항체 및 약학적으로 허용되는 담체를 포함하는 약학 조성물을 개시한다. 한 실시양태에서, 본 출원은 면역접합체 및 약학적으로 허용되는 담체를 포함하는, 약학 조성물을 개시한다. 한 실시양태에서, 약학 조성물은 방사성동위원소, 방사성핵종, 독소, 치료제, 화학치료제 또는 이의 조합을 추가로 포함한다.
한 실시양태에서, 본 출원은 본원에 개시된 이중특이성 항체의 유효량을 대상체에게 투여하는 단계를 포함하는, 암을 가진 대상체를 치료하는 방법을 개시한다. 한 실시양태에서, 암은 유방암, 결장직암, 췌장암, 두경부암, 흑색종, 난소암, 전립선암, 비소세포폐암, 소세포폐암, 신경교종, 식도암, 비인두암, 신장암, 위암, 간암, 방광암, 자궁경부암, 뇌암, 림프종, 백혈병, 골수종을 포함한다.
한 실시양태에서, 본 출원은 암을 가진 대상체를 치료하는 방법을 개시하며, 여기서 암은 PD-L1을 발현하는 세포를 포함한다.
한 실시양태에서, 본 출원은 치료제의 유효량을 공동 투여하는 단계를 추가로 포함하는, 암을 가진 대상체를 치료하는 방법을 개시한다. 일부 실시양태에서, 치료제는 항체, 화학요법제, 효소, 또는 이의 조합을 포함한다.
일부 실시양태에서, 치료제는 카페시타빈(capecitabine), 시스플라틴(cisplatin), 트라스투주맙(trastuzumab), 풀베스트란트(fulvestrant), 타목시펜(tamoxifen), 레트로졸(letrozole), 엑세메스탄(exemestane), 아나스트로졸(anastrozole), 아미노글루테티미드(aminoglutethimide), 테스톨락톤(testolactone), 보로졸(vorozole), 포르메스탄(formestane), 파드로졸(fadrozole), 레트로졸(letrozole), 에를로티닙(erlotinib), 라파티닙(lafatinib), 다사티닙(dasatinib), 게피티닙(gefitinib), 이마티닙(imatinib), 파조피닙(pazopinib), 라파티닙(lapatinib), 수니티닙(sunitinib), 닐로티닙(nilotinib), 소라페닙(sorafenib), 납-팔리탁셀(nab-palitaxel), 이의 유도체 또는 조합을 포함한다.
한 실시양태에서, 본 출원은 암을 가진 대상체를 치료하는 방법을 개시하며, 여기서 대상체는 인간이다.
한 실시양태에서, 본 출원은 본원에 개시된 이중특이성 항체의 유효 농도를 포함하는 용액을 개시하며, 여기서 용액은 대상체 내의 혈장이다.
본 출원의 또 다른 실시양태는 본 출원을 수행하기 위해 위해 고려되는 최상의 모드를 예시하는 방식으로 본 출원의 실시양태를 기재한, 하기의 상세한 설명으로부터 당해 분야의 숙련가에게 용이하게 명백해질 것이다. 알 수 있는 바와 같이, 본 출원은 다른 및 상이한 실시양태가 가능하며 이의 몇몇 세부 사항들이 모두 본 출원의 사상 및 범위를 벗어나지 않고, 다양하고 명백한 측면에서 수정될 수 있다. 따라서, 도면 및 상세한 설명은 제한적인 것이 아니라 사실상 예시적인 것으로 간주되어야 한다.
본 개시내용의 상기 및 다른 특징들은 첨부 도면과 관련하여, 하기의 설명 및 첨부된 청구범위로부터 보다 완전히 명백해질 수 있다. 이들 도면이 본 개시내용에 따라 배열된 몇몇 실시양태만을 묘사하므로, 그의 범위를 제한하는 것으로 고려되지 않아야한다는 것을 이해하고, 본 개시내용은 하기의 첨부 도면을 사용하여 추가의 특이성 및 세부 사항과 함께 기재될 수 있다:
도 1은 CTLA4, PD-1 및 PD-L1 항원을 표적화하는 예시적인 이중특이성 항체의 다어그램을 나타낸다;
도 2는 CHO 세포주의 표면 상에 발현된 PD-1 항원에 대한 예시적인 항-PD-1 항체의 결합을 나타낸다;
도 3은 CTLA4와 CD80 사이의 상호작용을 차단하는 대표적인 이중특이성 항체의 능력을 평가하는 생화학적 분석으로부터의 결과를 묘사한다.
도 4는 슈퍼 항원 SEB에 의한 PBMC의 자극을 나타내고; 도 4a는 PD224D1 x CT4 IgG1 널(null) 및 PL230C6 x CT4 IgG1 널에 의한 치료를 나타내고; 도 4b는 CT4 x PD224D1 IgG1 널, CT4 x PL221G5 IgG1 및 CT4 x PL221G5 IgG1 널에 의한 치료를 나타낸다;
도 5는 PD-1/PDL-1 경로에 대한 신호전달 분석으로부터의 결과를 나타낸다;
도 6은 수지상 세포 혼합된 림프구 반응(Dendritic Cell Mixed Lymphocytes Reaction) 연구로부터의 결과를 나타낸다;
도 7은 조절 T 세포 억제 분석으로부터의 결과를 나타내고; 도 7a는 CD8+ T 세포의 증식을 나타내고; 도 7b는 IFNg 생산을 나타낸다;
도 8은 예시적인 이중특이성 항체에 의한 치료에 대한 반응으로 CD8 T 세포 탈과립화(degranulation)를 나타낸다;
도 9는 MiXeno HCC287 마우스 종양 모델로부터의 결과를 나타낸다;
도 10은 Flu-특이적 CD8 T 세포의 증식에 대한 예시적인 이중특이성 항체의 효과를 나타낸다;
도 11은 CEFT 펩타이드 풀(pool)에 대한 PBMC 기억 반응으로부터의 결과를 나타낸다; 및
도 12는 예시적인 이중특이성 항체에 의한 방향전환된 T 세포 세포독성(Redirected T Cell Cytotoxicity)의 향상을 나타낸다.
본 출원의 실시양태에 대한 하기의 상세한 설명에서, 첨부 도면에 참조(reference)가 있고, 여기서 유사한 참조는 유사한 요소를 나타내며, 여기서 본 출원이 실시될 수 있는 구체적인 실시양태를 예시로써 나타낸다. 이들 실시양태는 당해 분야의 숙련가가 본 출원을 실시 할 수 있도록 충분히 상세하게 기재된다. 다른 예에서, 공지된 회로, 구조, 및 기술은 본 설명의 이해를 모호하게 하지 않기 위해 상세하게 나타내지 않았다. 따라서, 하기의 상세한 설명은 제한적인 의미로 받아들여지지 않아야하고, 본 출원의 범위는 첨부된 청구범위에 의해서만 한정된다.
본 개시내용은 인간 CTLA4, PD-1 또는 PD-L1에 특이적으로 결합하는 이중특이성 항체에 관한 것이다. 일부 실시양태에서, 이중특이성 항체는 CTLA4에 결합하는 제1 아암(arm) 및 PD-1 또는 PD-L1에 결합하는 제2 아암을 포함한다. 일부 실시양태에서, 이중특이성 항체는 PD-1 또는 PD-L1에 결합하는 제1 아암 및 CTLA4에 결합하는 제2 아암을 포함한다. 아암을 포함하는 도메인의 예는 Fab 및 scFv 도메인을 포함하나, 이에 제한되지는 않는다. 각 아암은 2개의 항원-결합 도메인을 함유하고 Fc 도메인을 통해 다른 아암에 연결된다. Fc 도메인은 인간 IgG1, IgG2, IgG3, IgG4 또는 조작된 동형(isotype)의 것일 수 있다.
본 출원의 이중특이성 항체(도 1)는 인간 CTLA4, 인간 PD-1 및 인간 PD-L1을 표적화한다. 이러한 표적화된 이중특이성 항체 각각은 항-CTLA4 (서열번호 91, 93) 및 항-인간 PD-1 (서열번호 95, 97, 131, 133) 또는 PD-L1 결합 도메인(서열번호 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129)을 지닌다. 결합 도메인 중 어느 하나는 C-말단에 배치하기 위해 scFv(VH-VL 배향)로, 또는 N-말단에 배치하기 위해 scFv(VL-VH 배향)로 전환되었다(각각 도 1a 및 도 1b).
일부 실시양태에서, 본원에 기재된 scFv 분자는 V-영역 배향(LH 또는 HL)에 상관 없이, VH 및 VL을 작동적으로 연결하는 20-아미노산 가요성 gly-gly-gly-gly-ser (G4S) X4 링커를 함유한다. 이중특이성 항체의 나머지 위치는 인간 IgG1 Fc 또는 IgG1 널 Fc 중쇄, VH-CH1-힌지(Hinge)-CH2-CH3, 및 이의 상응하는 카파 경쇄, VL-CL로 구성될 수 있다. scFv 도메인은 10-아미노산 (G4S) x 2 링커를 통해 IgG1 중쇄의 N-말단 또는 C-말단에 유전적으로 연결되어 있어서, 연속적인 ~ 100kDa의 중쇄 단량체 펩타이드를 생성한다. 적합한 경쇄와 공동 형질감염된 경우, 최종 대칭적 이중특이성 분자는 인간 IgG1 Fc (단백질 A)를 통해 정제되어 기능 활성을 평가하기 위해 분석될 수 있다.
중쇄 및 경쇄 유전자 "카세트(cassette)"는 V-영역이 제한 효소 부위를 사용하여 클로닝(cloning)될 수 있도록 이전에 작제되었다(도 1a 예: 중쇄의 경우 HindIII/NotI 및 경쇄의 경우 HindIII/BsiWI). 한 실시양태에서, "제한-없는(restriction-free) 클로닝" NEBuilder (NEB, 미국 매사추세츠주 입스위치(Ipswich, MA) 소재)가 사용되었다.
이중특이성 항체는 무손상 분자의 설계, 각각의 도메인에 대한 뉴클레오타이드 서열의 합성 및 클로닝, 포유동물 세포에서의 발현 및 최종 산물의 정제를 수반하는 공정을 통해 생산된다. 뉴클레오타이드 서열은 Geneious 10.2.3 소프트웨어 팩키지(Biomatters, 뉴질랜드 오클랜드(Auckland, NZ) 소재)를 사용하여 조립되었고 유전자 합성을 위해 그들의 성분 도메인으로 해체되었다(Genewiz, 미국 뉴저지주 사우쓰 플레인스필드(South Plainsfield, NJ) 소재). 하나의 예에서(도 1a), CT4 x PD224D1 IgG1 널 이중특이성 항체 (서열번호 2)의 중쇄는 인간 IgG1 널 Fc 도메인에 융합된 항-CTLA4 VH 도메인으로 구성되어있고(힌지, CH1, 및 CH2), 항-PD-1 scFV 도메인에 융합된 10-아미노산 (G4S) x 2 링커(클론 PD224D1)가 뒤따른다. NEBuilder 웹-기반 도구를 사용하여, 각각의 도메인이 이의 인접 도메인(flanking domain)을 20-30개의 뉴클레오타이드에 의해 겹치도록(overlap) 5' 및 3' 뉴클레오타이드를 각각의 도메인에 첨부하였고, 이는 부위-특이적인 재조합을 지시하므로, 단일 유전자 조립(assembly) 단계에서 각각의 도메인을 유전적으로 융합시킨다.
CT4 x PD224D1 IgG1 널의 경쇄는 인간 C 카파 도메인에 융합된 항-CTLA4 VL 도메인으로 구성되어 있다. 합성된 유전자 단편은 제한 효소 HindIII 및 BsiWI에 의해 분해된 후, 인간 C 카파 도메인과 함께 프레임-내 결찰되었다. 두 작제물 모두에 대해, 소량의 분취물을 이. 콜라이 DH10b (Invitrogen, 미국 캘리포니아주 칼스배드(Carlsbad, CA) 소재)로 형질전환시키고 TB + 카르베니실린(carbenicillin) 100㎍/ml 플레이트(Teknova, 미국 캘리포니아주 홀리스터(Hollister, CA) 소재)에 플레이팅하고 37℃에서 밤새 배양(incubating)하였다. 생성된 콜로니를 선택하고 2ml의 밤샘 배양물을 TB + 카르베니실린에 접종하였다. 밤샘 배양물로부터 DNA를 제조하고(Thermo-Fisherm, 미국 캘리포니아주 칼스배드 소재) 후속적으로 각각의 도메인에 인접한 서열분석 프라이머(Sigma, 미국 미주리주 세인트루이스(St. Louis, MO) 소재)를 사용하여 서열분석하였다(Genewiz, 미국 뉴저지주 사우쓰 플레인스필드 소재). 모든 DNA 서열은 Geneious에서 조립하고 분석하였다.
실시예
실시예 1: PD-L1 항원에 대한 항-PD-L1 항체의 결합
PD-L1 재조합 단백질에 대한 항-PD-L1 항체의 결합 친화성 및 동역학을 ForteBio Octet RED96 기기 상에서 표면 플라스몬 공명(Surface Plasmon Resonance)을 통해 평가하였다. 항원을 센서 칩 표면에 고정화하고 시험된 항체를 고정화된 항원 위에 흘렸다. 모든 분자는 예를 들어 표 1에 나타낸 바와 같이 항원에 대한 강한 결합을 나타냈다.
실시예 2: PD-1 항원에 대한 항-PD-1 항체의 결합
CHO 세포주의 표면에 발현되는 PD-1 항원에 대한 이중특이성 항체 및 이의 성분의 결합을 FACS 방법을 사용하여 평가하였다. 이중특이성 항체를 PD-1 항원을 발현하는 CHO 세포주와 배양시킨 후 Alexa Fluor 647 형광색소(fluorochrome)에 직접 접합된 2차 항-인간 항체로 검출하였다. 시험 항체의 세포 결합을 유동 세포분석기 BD LSRFortessa 상에서 분석하였다. 시험된 모든 항체가 한 자릿수의 나노몰 범위의 KD로 항원에 결합하였다(도 2).
실시예 3: CTLA4와 CD80 사이의 상호작용의 차단
CTLA4와 이의 리간드 CD80 사이의 상호작용을 차단하는 이중특이성 항체의 능력을 생화학적 상호작용 분석(Cisbio)에서 시험하였다. 요약하면, 이중특이성 항체를 CTLA4 및 CD80 단백질과 함께 배양하였다. CTLA4 및 CD80 단백질을 인식하고 HTRF 공여체/수여체 형광 쌍으로 표지한 검출 항체를 이후에 혼합물에 첨가하였다. CTLA4와 CD80 사이의 상호작용을 FRET 효율을 통해 평가하였다. 시험된 모든 이중특이성 항체가 CTLA4와 CD80 사이의 상호작용을 차단할 수 있었다(도 3).
실시예 4: 슈퍼항원 SEB에 의한 PBMC의 자극
슈퍼 항원 SEB에 의한 자극 후에 인간 말초 혈액 단핵 세포(PBMC)로부터 사이토카인 방출을 향상시키는 이중특이성 항체의 능력을 평가하였다. 도 4a 및 도 4b에서 나타낸 바와 같이, 모든 이중특이성 분자는 SEB에 의한 자극 시에 PBMC에 의한 IL-2의 생산을 유의적으로 향상시킬 수 있었다.
실시예 5: PD-1/PD-L1 경로 신호전달
PD-1/PD-L1 경로를 차단하는 능력에 대해 이중특이성 항체를 시험하였다. 요약하면, 시험 분자를 PD-1 수용체 및 루시퍼라아제(luciferase) NFAT 리포터를 발현하는 Jurkat 리포터 세포주 및 CHO-PD-L1 세포주 (Promega)와 함께 배양하였다. PD-1/PD-L1 경로를 통한 신호전달을 차단하는 시험 항체의 능력을 NFAT 신호절달에서의 증가를 통해 평가하였다. 결과적으로 NFAT 신호전달을 루시퍼라아제 리포터 유전자의 활성을 통해 모니터링하였다. 분석을 플레이트 판독기(plate reader)(Clariostar, BMG) 상에서 판독하였다. 시험된 모든 이중특이성 항체 및 단일클론 항체 대조군은 PD-1/PD-L1 신호전달을 차단할 수 있었다(도 5).
실시예 6: 수지상 세포 혼합된 백혈구 반응
수지상 세포 혼합된 백혈구 반응(MLR)을 향상시키는 능력에 대해 이중특이성 항체를 시험하였다. 시험 분자를 하나의 공여체로부터의 수지상 세포 및 다른 공여체로부터 단리된 T 세포와 함께 6일 동안 함께 배양하였다. 수지상 세포를 GM-CSF 및 IL-4의 존재 하에서 단핵구로부터 시험관내 분화시켰다. StemCell 단리 키트로 단핵구 및 T 세포 집단을 PBMC로부터 단리시켰다. MLR을 향상시키는 시험 분자의 능력을 분비된 IFNγ를 통해 평가하였다. 도 6에 나타낸 바와 같이, 시험된 모든 이중특이성 항체는 IFNγ의 생산을 증대시킬 수 있었다.
실시예 7: 조절 T 세포에 의한 CD8 T 세포의 억제
효과기(effector) CD8 T 세포 증식 및 사이토카인 생산에 대한 조절 T 세포의 억제 효과를 차단하는 능력에 대해 이중특이성 항체를 시험하였다. CD8 T 세포를 StemCell 단리 키트로 단리하고 셀트레이스(CellTrace) 염료(써모피셔)로 표지하였다. 수지상 세포를 상기 MLR 연구에서 기재한 바와 같이 제조하였다. 조절 T 세포를 StemCell 단리 키트에 의해 PBMC로부터 단리하고 시험관 내 확장시켰다. 이중특이성 항체를 효과기 CD8 T 세포, 수지상 세포 및 조절 T 세포와 함께 4일 동안 배양하였다. 조절 T 세포의 존재 하에서 효과기 CD8 T 세포 기능을 구출하는 이중특이성 항체의 능력을 효과기 CD8 T 세포의 증식(도 7a) 및 분비된 IFNγ(도 7b)를 통해 평가하였다.
실시예 8: CD8 T 세포 탈과립화(degranulation)
세포독성 CD8 T 세포에 영향을 끼치는 이중특이성 분자의 능력을 본 연구에서 평가하였다. 요약하면, CD8 T 세포를 StemCell 단리 키트로 정제하고 이중특이성 시험 분자의 존재 하에 CEFT 펩타이드 풀(pool)(JPT Peptide Technologies)로 자극시켰다. 배지를 IL-7 및 IL-21로 보충하였다. 11일째에 CD8 T 세포를 브레펠딘(Brefeldin) 및 모넨신(Monensin) 및 형광색소로 직접 표지된 항-CD107a 항체의 존재 하에 펩타이드로 재자극시켰다. 24시간 후 CD8 T 세포를 형광색소에 직접 접합된 항-IFNγ 항체로 염색하고 유동 세포분석기 BD LSRFortessa 상에서 평가하였다. 도 8에 나타낸 바와 같이, 시험된 모든 이중특이성 항체는 세포독성 IFNγ 양성 T 세포의 수를 증가시킬 수 있었다.
실시예 9: 믹세노(MiXeno) 마우스 종양 모델
인간화 마우스 모델을 사용하여 생체내 종양 성장을 억제하는 이 부류의 이중특이성 항체의 능력을 평가하였다. 요약하면, NOG 마우스를 인간 PBMC (마우스 당 5x106개 세포)로 재구성하였다. 3일째에 동물에게 인간 폐암 세포주 HCC827 (0.5E6 세포/동물)를 피하 접종하고 이중특이성 항체 및 대조군 항체로 격주 치료를 시작하였다. 종양 용적을 2-3일 마다 측정하였다. 동물 중량을 모니터링하였다. 시험된 이중특이성 항체는 대조군 항체보다 종양 성장을 더 우수하게 억제할 수 있었다(도 9).
실시예 10: Flu-특이적 T 세포의 증식
항원 특이적 CD8 T 세포의 증식을 증대시키는 이중특이성 항체의 능력을 본 연구에서 평가하였다. CD8 T 세포를 StemCell 단리 키트로 PBMC로부터 정제하고, 인플루엔자 특이적 펩타이드(JPT Peptide Technologies)로 펄스(pulse)시키고 이중특이성 항체의 존재 하에서 14일 동안 배양하였다. 배지를 IL-7 및 IL-21로 보충하였다. 15일째에 세포를 펩타이드 특이적 MHC 덱스트라머(dextramer)(Immudex)로 염색시키고 유동 세포분석기 BD LSRFortessa 상에서 평가하였다. 시험된 모든 이중특이성 항체는 항원 특이적 CD8 T 세포의 수를 증가시킬 수 있었다(도 10).
실시예 11: CEFT 펩타이드 풀에 대한 PBMC 기억 반응
T 세포 기억 반응을 증대시키는 이중특이성 항체의 능력을 평가하였다. 요약하면, PBMC를 CMV, EBV, 인플루엔자 및 테타너스(Tetanus)(JPT Peptide Technologies)에 특이적인 펩타이드의 존재 하에 4-5일 동안 배양하였다. 분비된 IFNγ의 양을 정량화하였다. 도 11에 나타낸 바와 같이, 이중특이성 CT4 x PD224D1는 대조군 치료에 비해 IFNγ의 생산을 수배 향상시킬 수 있었다.
실시예 12: 방향전환된 T 세포 세포독성의 향상
종양 세포주 표적에 대한 방향전환된 T 세포 세포독성(Redirected T cell Cytotoxicity; RTCC)을 향상시키는 능력에 대해 이중특이성 항체를 평가하였다. 종양 세포주는 렌티바이러스 형질도입(Sartorius)을 통해 전달된 핵-국재화된 적색 형광 단백질(nucleus-localized Red Fluorescent Protein ;RFP)을 안정적으로 발현하였다. 종양 세포를 PBMC 및 주어진 종양 세포주에 대해 특이적인 T 세포 관여항체 분자와 함께 공동 배양하였다. 이중특이성 항체를 공동 배양물에 첨가하였다. 종양 세포의 분해를 RFP 표지된 종양 세포 핵을 계수함으로써 평가하였다. 이미지(image)를 살아있는 세포 이미저(imager) 인큐사이트(IncuCyte)(사르토리우스) 상에서 획득하였다. 항체의 활성을 96 시간의 배양 후 평가하였다. 4개의 PBMC 공여체를 본 연구에서 시험하였다. 시험된 모든 이중특이성 항체는 적어도 하나의 시험된 PBMC 공여체 내에서 RTCC 활성을 향상시킬 수 있었다(도 12).
본 개시내용은 특정 실시양태 또는 실시예를 참조하여 기재되었지만, 실시양태가 예시적이라는 것과 개시 범위가 이에 제한되지 않는다는 것이 이해될 수 있다. 본 개시 내용의 대안적인 실시양태는 본 개시 내용이 속하는 당해 분야의 숙련가에게 명백해질 수 있다. 이러한 대안적인 실시양태는 본 개시내용의 범위 내에 포함되는 것으로 고려된다. 따라서, 본 개시 내용의 범위는 첨부된 청구범위에 의해서 한정되고 상기 설명에 의해 뒷받침된다. 본 개시내용에 인용되거나 언급된 모든 참고문헌은 그 전문이 본원에 참고로 포함된다.
서열번호 01: CT4 x PD224D1 뉴클레오타이드 서열 (nt)
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCCTCAGTAGCTATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTACATCGGCTACATTGGTGATACTACTGGCATAGCCTACGCGAGCTGGGCGAATGGCAGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGGCTGGTCCTACTTAGACATCTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCCCTTGTGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATCAGGCCTCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATATGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAGGCGGTTATTATAGTGCTGCCCTTAATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 02: CT4 x PD224D1 아미노산 서열 (aa)
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCTASGFSLSSYAMSWVRQAPGKGLEYIGYIGDTTGIAYASWANGRFTISKDNTKNTVDLQMNSLRAEDTAVYYCARGWSYLDIWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSALVMTQSPSSLSASVGDRVTITCQASQNIYSNLAWYQQKPGKVPKLLIYQASTLASGVPSRFSGSGYGTDFTLTISSLQPEDVATYYCQGGYYSAALNTFGGGTKVEIK
서열번호 03: CT4 카파 경쇄 nt
GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
CGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 04: CT4 카파 경쇄 aa
EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 05: CT4 x PL230C6 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGTCGGTGGAGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACCGCCTCTGGAATCGACCTTAATACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTTGGAATCATTACTTATAGTGGTAGTAGATACTACGCGAACTGGGCGAAAGGCCGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTATATGAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCCGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGTCAGGCCAGTGAGGACATTTATAGCTTCTTGGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCATTCTGCATCCTCTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATGGTAAAAATAATGTTGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 06: CT4 x PL230C6 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQSVEESGGGLVQPGGSLRLSCTASGIDLNTYDMIWVRQAPGKGLEWVGIITYSGSRYYANWAKGRFTISKDNTKNTVYLQMNSLRAEDTAVYYCARDYMSGSHLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSVSASVGDRVTIKCQASEDIYSFLAWYQQKPGKAPKLLIHSASSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYGKNNVDNAFGGGTKVEIK
서열번호 07: CT4 x PL221G5 널2 Fc nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 08: CT4 x PL221G5 널 Fc aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVEIK
서열번호 09: CT4 x PL231H2 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCCAGCCTGGGGGCTCCCTGAGACTCTCCTGTACAACTTCTGGAATCGACCTTAGTACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGGAATCATTAGTTATGTTGGTAACACATACTACGCGAGCTGGGCGAAAGGCCGATTCACCCTCTCCAAAGACAATACCTCGACCACGGTGGATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTTTATTAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGTCAGGCCAGTGAGAGCATTAGTAGCTTCTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTTTTCTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATAGTAAAAGTAATGTGGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 10: CT4 x PL231H2 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGLVQPGGSLRLSCTTSGIDLSTYDMIWVRQAPGKGLEWVGIISYVGNTYYASWAKGRFTLSKDNTSTTVDLQMNSLRAEDTAVYYCARDFISGSHLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSVSASVGDRVTINCQASESISSFLSWYQQKPGKAPKLLIFSASTLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYSKSNVDNAFGGGTKVEIK
서열번호 11: CT4 x PL004B5 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCCTCAGTAGCTACTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTGATACTAATGTTTATATATACTACGCGAACTGGGCAAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGATATGTGGGTAATAATGATGATTATATTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATAATGGCTACTGGTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCTAGGCAGTTATACTAGTAGTACTGAGAACTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 12: CT4 x PL004B5 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFSLSSYWMSWVRQAPGKGLEWIGVIDTNVYIYYANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYVGNNDDYINLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQSSQSVYNGYWLSWYQQKPGKAPKLLIYGASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLGSYTSSTENSFGGGTKVEIK
서열번호 13: CT4 x PL004B9 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGTGTCTGGAATCGACCTCAGTGTCATCAATATGGGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAACCATTACTTATGTTGGTAACACATATTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAAAACCTCGACCACGGTGGATCTTAAAATCACCAGTCCGACAACCGAGGACACGGCTGTGTATTACTGTGCGAGAGAATCTGGTACTATTTATTACAGTTACTTTAACTTGTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCATTCGAATTGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGCCAGGCCAGTGAAAGCATTAGCAACTACTTATCCTGGTATCAGCAGATTCCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCAATCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAAGCTATTATGGTGGTGGTAGTGCCTATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 14: CT4 x PL004B9 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCTVSGIDLSVINMGWVRQAPGKGLEWIGTITYVGNTYYASWAKGRFTISKTSTTVDLKITSPTTEDTAVYYCARESGTIYYSYFNLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAFELTQSPSSLSASVGDRVTIKCQASESISNYLSWYQQIPGKVPKLLIYYASNLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQSYYGGGSAYTFGGGTKVEIK
서열번호 15: CT4 x PD206F12 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCGACTTCAGTAGCGGCTACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTTGATCGCATGCATTTATGCTGGTACTAGTGGTAGTACTTCCTACGCGAGCTGGGCGAGAGGCAGATTCACCATCTCCGAAACCTCCAAGAACACGGTGACTCTTCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAATCTTTACACTTACAATAGCTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATGATAACAACTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATACAGTATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCACTTATTATAGTAGTGGTTGGAACTTTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 16: CT4 x PD206F12 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFDFSSGYWICWVRQAPGKGLELIACIYAGTSGSTSYASWARGRFTISETSKNTVTLQMNSLRAEDSAVYYCARNLYTYNSLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQSSQSVYDNNWLAWYQQKPGKAPKLLIYTVSTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGTYYSSGWNFAFGGGTKVEIK
서열번호 17: CT4 x PD215A1 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAGGAGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCTTTAGCAGCTACTGGATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTACGACTGGTAGTGGTAGCACTTACTACGCGAGCTGGGCGAAGCGCCGGTTCACCATCTCCAAAGACAATTCCAAGAACACGGTGACTCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTACGAGAGCATTTGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTTACAGCTACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAAGATTTTGCAACTTACTACTGTCAAAGCAGTTGGTTGAGTGGTGCTGTTGGTAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 18: CT4 x PD215A1 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQEQLLESGGGLVQPGGSLRLSCTASGFSFSSYWMCWVRQAPGKGLEWIGCITTGSGSTYYASWAKRRFTISKDNSKNTVTLQMNSLRAEDTAVYYCTRAFDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCQASQSIYSYLNWYQQKPGKAPKLLIYGASNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQSSWLSGAVGNAFGGGTKVEIK
서열번호 19: CT4 x PD220F6 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAGGAGCAGGTGAAGGAGACCGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGCAGCTATGGAGTGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGCATTGATTTTTCCCGGGATTGGTTTCAAAGACTACGCGAGCTGGGTGAATGGCCGGTTCACCCTCTCCAGCGACAACGCCCAGAACACTGTGGAACTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGATTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCCGAGTGTTTATAGTAACTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTGCAGGCGGTTATAGTAGTAGTACTCGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 20: CT4 x PD220F6 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQEQVKETGGGLVQPGGSLRLSCAASGFTISSYGVSWVRQAPGKGLEWVALIFPGIGFKDYASWVNGRFTLSSDNAQNTVELQMNSLRAEDTAVYYCARDLDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCQSSPSVYSNYLSWYQQKPGKVPKLLIYYASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCAGGYSSSTRAFGGGTKVEIK
서열번호 21: CT4 x PD225G11 nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCAGCCACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTTATACTGGTAGTATTGATGTCTTTTACTACGCGAGCTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGCCGCTAATACTGATACTACCTACTTTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCCTATGATATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAGGCCAGTCAGAGCATTAACAACCAACTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCACCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCATGTTCATTATTGCAGTGGTGGTAGTTGTTTTTGGGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 22: CT4 x PD225G11 aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGGLVQPGGSLRLSCAASGFTFSSSHWICWVRQAPGKGLEWIACIYTGSIDVFYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARAANTDTTYFNLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSLSASVGDRVTINCQASQSINNQLSWYQQKPGKVPKLLIYGASTLASGVPSRFTGSGSGTDFTLTISSLQPEDVATYYCHVHYCSGGSCFWAFGGGTKVEIK
서열번호 23: G4S x 4 nt
GGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCT
서열번호 24: G4S x 4 aa
GGGGSGGGGSGGGGSGGGGS
서열번호 25: PL230C6 x CT4 nt
CAGTCGGTGGAGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACCGCCTCTGGAATCGACCTTAATACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTTGGAATCATTACTTATAGTGGTAGTAGATACTACGCGAACTGGGCGAAAGGCCGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTATATGAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 26: PL230C6 x CT4 aa
QSVEESGGGLVQPGGSLRLSCTASGIDLNTYDMIWVRQAPGKGLEWVGIITYSGSRYYANWAKGRFTISKDNTKNTVYLQMNSLRAEDTAVYYCARDYMSGSHLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 27: PL230C6 카파 경쇄 nt
GCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGTCAGGCCAGTGAGGACATTTATAGCTTCTTGGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCATTCTGCATCCTCTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATGGTAAAAATAATGTTGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
CGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 28: PL230C6 카파 경쇄 aa
AYDMTQSPSSVSASVGDRVTIKCQASEDIYSFLAWYQQKPGKAPKLLIHSASSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYGKNNVDNAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 29: PD224D1 x CT4 nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCCTCAGTAGCTATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTACATCGGCTACATTGGTGATACTACTGGCATAGCCTACGCGAGCTGGGCGAATGGCAGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGGCTGGTCCTACTTAGACATCTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 30: PD224D1 x CT4 aa
EVQLVESGGGLVQPGGSLRLSCTASGFSLSSYAMSWVRQAPGKGLEYIGYIGDTTGIAYASWANGRFTISKDNTKNTVDLQMNSLRAEDTAVYYCARGWSYLDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 31: PD224 경쇄 nt
GCCCTTGTGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATCAGGCCTCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATATGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAGGCGGTTATTATAGTGCTGCCCTTAATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA CGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 32: PD224 경쇄 aa
ALVMTQSPSSLSASVGDRVTITCQASQNIYSNLAWYQQKPGKVPKLLIYQASTLASGVPSRFSGSGYGTDFTLTISSLQPEDVATYYCQGGYYSAALNTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 33: PL221G5 x CT4 널 Fc nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 34: PL221G5 x CT4 널 Fc aa
EVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 35: PL221G5 경쇄 nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 36: PL221G5 경쇄 aa
DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 37: PL231H2 x CT4 널 Fc nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCCAGCCTGGGGGCTCCCTGAGACTCTCCTGTACAACTTCTGGAATCGACCTTAGTACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGGAATCATTAGTTATGTTGGTAACACATACTACGCGAGCTGGGCGAAAGGCCGATTCACCCTCTCCAAAGACAATACCTCGACCACGGTGGATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTTTATTAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 38: PL231H2 x CT4 널 Fc aa
QVQLVESGGGLVQPGGSLRLSCTTSGIDLSTYDMIWVRQAPGKGLEWVGIISYVGNTYYASWAKGRFTLSKDNTSTTVDLQMNSLRAEDTAVYYCARDFISGSHLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 39: PL231H2 경쇄 nt
GCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGTCAGGCCAGTGAGAGCATTAGTAGCTTCTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTTTTCTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATAGTAAAAGTAATGTGGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 40: PL231H2 경쇄 aa
AYDMTQSPSSVSASVGDRVTINCQASESISSFLSWYQQKPGKAPKLLIFSASTLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYSKSNVDNAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 41: PL004B5 x CT4 nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCCTCAGTAGCTACTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTGATACTAATGTTTATATATACTACGCGAACTGGGCAAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGATATGTGGGTAATAATGATGATTATATTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 42: PL004B5 x CT4 aa
EVQLVESGGGLVQPGGSLRLSCAASGFSLSSYWMSWVRQAPGKGLEWIGVIDTNVYIYYANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYVGNNDDYINLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 43: PL004B5 경쇄 nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATAATGGCTACTGGTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCTAGGCAGTTATACTAGTAGTACTGAGAACTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 44: PL004B5 경쇄 aa
DIQMTQSPSTLSASVGDRVTITCQSSQSVYNGYWLSWYQQKPGKAPKLLIYGASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLGSYTSSTENSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 45: PL004B9 x CT4 nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGTGTCTGGAATCGACCTCAGTGTCATCAATATGGGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAACCATTACTTATGTTGGTAACACATATTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAAAACCTCGACCACGGTGGATCTTAAAATCACCAGTCCGACAACCGAGGACACGGCTGTGTATTACTGTGCGAGAGAATCTGGTACTATTTATTACAGTTACTTTAACTTGTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 46: PL004B9 x CT4 aa
EVQLVESGGGLVQPGGSLRLSCTVSGIDLSVINMGWVRQAPGKGLEWIGTITYVGNTYYASWAKGRFTISKTSTTVDLKITSPTTEDTAVYYCARESGTIYYSYFNLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 47: PL004B9 경쇄 nt
GCATTCGAATTGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGCCAGGCCAGTGAAAGCATTAGCAACTACTTATCCTGGTATCAGCAGATTCCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCAATCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAAGCTATTATGGTGGTGGTAGTGCCTATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 48: PL004B9 경쇄 aa
AFELTQSPSSLSASVGDRVTIKCQASESISNYLSWYQQIPGKVPKLLIYYASNLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQSYYGGGSAYTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 49: PD206F12 x CT4 nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCGACTTCAGTAGCGGCTACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTTGATCGCATGCATTTATGCTGGTACTAGTGGTAGTACTTCCTACGCGAGCTGGGCGAGAGGCAGATTCACCATCTCCGAAACCTCCAAGAACACGGTGACTCTTCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAATCTTTACACTTACAATAGCTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 50: PD206F12 x CT4 aa
EVQLVESGGGLVQPGGSLRLSCAASGFDFSSGYWICWVRQAPGKGLELIACIYAGTSGSTSYASWARGRFTISETSKNTVTLQMNSLRAEDSAVYYCARNLYTYNSLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 51: PD206F12 경쇄 nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATGATAACAACTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATACAGTATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCACTTATTATAGTAGTGGTTGGAACTTTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 52: PD206F12 경쇄 aa
DIQMTQSPSTLSASVGDRVTITCQSSQSVYDNNWLAWYQQKPGKAPKLLIYTVSTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGTYYSSGWNFAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 53: PD215A1 x CT4 nt
CAGGAGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCTTTAGCAGCTACTGGATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTACGACTGGTAGTGGTAGCACTTACTACGCGAGCTGGGCGAAGCGCCGGTTCACCATCTCCAAAGACAATTCCAAGAACACGGTGACTCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTACGAGAGCATTTGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 54: PD215A1 x CT4 aa
QEQLLESGGGLVQPGGSLRLSCTASGFSFSSYWMCWVRQAPGKGLEWIGCITTGSGSTYYASWAKRRFTISKDNSKNTVTLQMNSLRAEDTAVYYCTRAFDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 55: PD215A1 경쇄 nt
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTTACAGCTACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAAGATTTTGCAACTTACTACTGTCAAAGCAGTTGGTTGAGTGGTGCTGTTGGTAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 56: PD215A1 경쇄 aa
DIQMTQSPSSLSASVGDRVTITCQASQSIYSYLNWYQQKPGKAPKLLIYGASNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQSSWLSGAVGNAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 57: PD220F6 x CT4 nt
CAGGAGCAGGTGAAGGAGACCGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGCAGCTATGGAGTGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGCATTGATTTTTCCCGGGATTGGTTTCAAAGACTACGCGAGCTGGGTGAATGGCCGGTTCACCCTCTCCAGCGACAACGCCCAGAACACTGTGGAACTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGATTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 58: PD220F6 x CT4 aa
QEQVKETGGGLVQPGGSLRLSCAASGFTISSYGVSWVRQAPGKGLEWVALIFPGIGFKDYASWVNGRFTLSSDNAQNTVELQMNSLRAEDTAVYYCARDLDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 59: PD220F6 경쇄 nt
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCCGAGTGTTTATAGTAACTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTGCAGGCGGTTATAGTAGTAGTACTCGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 60: PD220F6 경쇄 aa
DIQMTQSPSSLSASVGDRVTITCQSSPSVYSNYLSWYQQKPGKVPKLLIYYASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCAGGYSSSTRAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 61: PD225G11 x CT4 nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCAGCCACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTTATACTGGTAGTATTGATGTCTTTTACTACGCGAGCTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGCCGCTAATACTGATACTACCTACTTTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 62: PD225G11 x CT4 aa
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSSHWICWVRQAPGKGLEWIACIYTGSIDVFYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARAANTDTTYFNLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 63: PD225G11 경쇄 nt
GCCTATGATATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAGGCCAGTCAGAGCATTAACAACCAACTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCACCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCATGTTCATTATTGCAGTGGTGGTAGTTGTTTTTGGGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGT
서열번호 64: PD225G11 경쇄 aa
AYDMTQSPSSLSASVGDRVTINCQASQSINNQLSWYQQKPGKVPKLLIYGASTLASGVPSRFTGSGSGTDFTLTISSLQPEDVATYYCHVHYCSGGSCFWAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
서열번호 65: CT4 중쇄 신호 펩타이드 뉴클레오타이드 서열 nt
ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGGGTCCTGTCC
서열번호 66: CT4 중쇄 신호 펩타이드 뉴클레오타이드 서열 aa
MKHLWFFLLLVAAPRWVLS
서열번호 67: PL230/PD224 중쇄 신호 펩타이드 nt
ATGGCTGTCTTGGGGCTGCTCTTCTGCCTGGTGACATTCCCAAGCTGTGTCCTATCC
서열번호 68: PL230/PD224 중쇄 신호 펩타이드 aa
MAVLGLLFCLVTFPSCVLS
서열번호 69: PL230/PD224 경쇄 신호 펩타이드 nt
ATGAGGGCCCCTGCTCAGTTTCTTGGCTTCTTGCTTTTCTGGATTCCAGCCTCCAGAAGT
서열번호 70: PL230/PD224 경쇄 신호 펩타이드 aa
MRAPAQFLGFLLFWIPASRS
서열번호 71: CT4 scFv nt
CAGGTGCAATTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 72: CT4 scFv aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 73: PD224D1 scFv nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGC
CTCTGGATTCTCCCTCAGTAGCTATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTACATCGGCTACATTGGTGATACTACTGGCATAGCCTACGCGAGCTGGGCGAATGGCAGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGGCTGGTCCTACTTAGACATCTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCCCTTGTGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATCAGGCCTCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATATGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAGGCGGTTATTATAGTGCTGCCCTTAATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 74: PD224D1 scFv aa
EVQLVESGGGLVQPGGSLRLSCTASGFSLSSYAMSWVRQAPGKGLEYIGYIGDTTGIAYASWANGRFTISKDNTKNTVDLQMNSLRAEDTAVYYCARGWSYLDIWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSALVMTQSPSSLSASVGDRVTITCQASQNIYSNLAWYQQKPGKVPKLLIYQASTLASGVPSRFSGSGYGTDFTLTISSLQPEDVATYYCQGGYYSAALNTFGGGTKVEIK
서열번호 75: PD206F12 scFv nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCGACTTCAGTAGCGGCTACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTTGATCGCATGCATTTATGCTGGTACTAGTGGTAGTACTTCCTACGCGAGCTGGGCGAGAGGCAGATTCACCATCTCCGAAACCTCCAAGAACACGGTGACTCTTCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAATCTTTACACTTACAATAGCTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATGATAACAACTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATACAGTATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCACTTATTATAGTAGTGGTTGGAACTTTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 76: PD206F12 scFv aa
EVQLVESGGGLVQPGGSLRLSCAASGFDFSSGYWICWVRQAPGKGLELIACIYAGTSGSTSYASWARGRFTISETSKNTVTLQMNSLRAEDSAVYYCARNLYTYNSLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQSSQSVYDNNWLAWYQQKPGKAPKLLIYTVSTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGTYYSSGWNFAFGGGTKVEIK
서열번호 77: PD215A1 scFv nt
CAGGAGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCTTTAGCAGCTACTGGATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTACGACTGGTAGTGGTAGCACTTACTACGCGAGCTGGGCGAAGCGCCGGTTCACCATCTCCAAAGACAATTCCAAGAACACGGTGACTCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTACGAGAGCATTTGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTTACAGCTACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAAGATTTTGCAACTTACTACTGTCAAAGCAGTTGGTTGAGTGGTGCTGTTGGTAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 78: PD215A1 scFv aa
QEQLLESGGGLVQPGGSLRLSCTASGFSFSSYWMCWVRQAPGKGLEWIGCITTGSGSTYYASWAKRRFTISKDNSKNTVTLQMNSLRAEDTAVYYCTRAFDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCQASQSIYSYLNWYQQKPGKAPKLLIYGASNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQSSWLSGAVGNAFGGGTKVEIK
서열번호 79: PD225G11 scFv nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCAGCCACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTTATACTGGTAGTATTGATGTCTTTTACTACGCGAGCTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGCCGCTAATACTGATACTACCTACTTTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCCTATGATATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAGGCCAGTCAGAGCATTAACAACCAACTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCACCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCATGTTCATTATTGCAGTGGTGGTAGTTGTTTTTGGGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 80: PD225G11 scFv aa
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSSHWICWVRQAPGKGLEWIACIYTGSIDVFYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARAANTDTTYFNLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSLSASVGDRVTINCQASQSINNQLSWYQQKPGKVPKLLIYGASTLASGVPSRFTGSGSGTDFTLTISSLQPEDVATYYCHVHYCSGGSCFWAFGGGTKVEIK
서열번호 81: PL230C6 scFv nt
CAGTCGGTGGAGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACCGCCTCTGGAATCGACCTTAATACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTTGGAATCATTACTTATAGTGGTAGTAGATACTACGCGAACTGGGCGAAAGGCCGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTATATGAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCCGGTGGAGGCGGTTCAGGCGGAGGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGTCAGGCCAGTGAGGACATTTATAGCTTCTTGGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCATTCTGCATCCTCTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATGGTAAAAATAATGTTGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 82: PL230C6 scFv aa
QSVEESGGGLVQPGGSLRLSCTASGIDLNTYDMIWVRQAPGKGLEWVGIITYSGSRYYANWAKGRFTISKDNTKNTVYLQMNSLRAEDTAVYYCARDYMSGSHLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSVSASVGDRVTIKCQASEDIYSFLAWYQQKPGKAPKLLIHSASSLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYGKNNVDNAFGGGTKVEIK
서열번호 83: PL231H2 scFv nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCCAGCCTGGGGGCTCCCTGAGACTCTCCTGTACAACTTCTGGAATCGACCTTAGTACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGGAATCATTAGTTATGTTGGTAACACATACTACGCGAGCTGGGCGAAAGGCCGATTCACCCTCTCCAAAGACAATACCTCGACCACGGTGGATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTTTATTAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGTTCTGCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGTCAGGCCAGTGAGAGCATTAGTAGCTTCTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTTTTCTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATAGTAAAAGTAATGTGGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 84: PL231H2 scFv aa
QVQLVESGGGLVQPGGSLRLSCTTSGIDLSTYDMIWVRQAPGKGLEWVGIISYVGNTYYASWAKGRFTLSKDNTSTTVDLQMNSLRAEDTAVYYCARDFISGSHLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAYDMTQSPSSVSASVGDRVTINCQASESISSFLSWYQQKPGKAPKLLIFSASTLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYSKSNVDNAFGGGTKVEIK
서열번호 85: PL221G5 scFv nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 86: PL221G5 scFv aa
EVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVEIK
서열번호 87: PL004B5 scFv nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCCTCAGTAGCTACTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTGATACTAATGTTTATATATACTACGCGAACTGGGCAAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGATATGTGGGTAATAATGATGATTATATTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATAATGGCTACTGGTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCTAGGCAGTTATACTAGTAGTACTGAGAACTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 88: PL004B5 scFv aa
EVQLVESGGGLVQPGGSLRLSCAASGFSLSSYWMSWVRQAPGKGLEWIGVIDTNVYIYYANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYVGNNDDYINLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQSSQSVYNGYWLSWYQQKPGKAPKLLIYGASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLGSYTSSTENSFGGGTKVEIK
서열번호 89: PL004B9 scFv nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGTGTCTGGAATCGACCTCAGTGTCATCAATATGGGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAACCATTACTTATGTTGGTAACACATATTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAAAACCTCGACCACGGTGGATCTTAAAATCACCAGTCCGACAACCGAGGACACGGCTGTGTATTACTGTGCGAGAGAATCTGGTACTATTTATTACAGTTACTTTAACTTGTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGCATTCGAATTGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGCCAGGCCAGTGAAAGCATTAGCAACTACTTATCCTGGTATCAGCAGATTCCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCAATCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAAGCTATTATGGTGGTGGTAGTGCCTATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 90: PL004B9 scFv aa
EVQLVESGGGLVQPGGSLRLSCTVSGIDLSVINMGWVRQAPGKGLEWIGTITYVGNTYYASWAKGRFTISKTSTTVDLKITSPTTEDTAVYYCARESGTIYYSYFNLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSAFELTQSPSSLSASVGDRVTIKCQASESISNYLSWYQQIPGKVPKLLIYYASNLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQSYYGGGSAYTFGGGTKVEIK
서열번호 91: CT4 VH nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATACTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGACATTTATATCATATGATGGAAACAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTATATATTACTGTGCGAGGACCGGCTGGCTGGGGCCCTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCA
서열번호 92: CT4 VH aa
QVQLVESGGGVVQPGRSLRLSCAASGFTFSSYTMHWVRQAPGKGLEWVTFISYDGNNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAIYYCARTGWLGPFDYWGQGTLVTVSS
서열번호 93: CT4 VL nt
GAAATTGTGTTGACGCAGTCTCCAGGCACCCTGTCTTTGTCTCCAGGGGAAAGAGCCACCCTCTCCTGCAGGGCCAGTCAGAGTGTTGGCAGCAGCTACTTAGCCTGGTACCAGCAGAAACCTGGCCAGGCTCCCAGGCTCCTCATCTATGGTGCATTCAGCAGGGCCACTGGCATCCCAGACAGGTTCAGTGGCAGTGGGTCTGGGACAGACTTCACTCTCACCATCAGCAGACTGGAGCCTGAAGATTTTGCAGTGTATTACTGTCAGCAGTATGGTAGCTCACCGTGGACGTTCGGCCAAGGGACCAAGGTGGAAATCAAA
서열번호 94: CT4 VL aa
EIVLTQSPGTLSLSPGERATLSCRASQSVGSSYLAWYQQKPGQAPRLLIYGAFSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSPWTFGQGTKVEIK
서열번호 95: PD224D1 VH nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCCTCAGTAGCTATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTACATCGGCTACATTGGTGATACTACTGGCATAGCCTACGCGAGCTGGGCGAATGGCAGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGGCTGGTCCTACTTAGACATCTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGC
서열번호 96: PD224D1 VH aa
EVQLVESGGGLVQPGGSLRLSCTASGFSLSSYAMSWVRQAPGKGLEYIGYIGDTTGIAYASWANGRFTISKDNTKNTVDL
QMNSLRAEDTAVYYCARGWSYLDIWGQGTLVTVSS
서열번호 97: PD224D1 VL nt
GCCCTTGTGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATCAGGCCTCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATATGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAGGCGGTTATTATAGTGCTGCCCTTAATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 98: PD224D1 VL aa
ALVMTQSPSSLSASVGDRVTITCQASQNIYSNLAWYQQKPGKVPKLLIYQASTLASGVPSRFSGSGYGTDFTLTISSLQP
EDVATYYCQGGYYSAALNTFGGGTKVEIK
서열번호 99: PD206F12 VH nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCGACTTCAGTAGCGGCTACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTTGATCGCATGCATTTATGCTGGTACTAGTGGTAGTACTTCCTACGCGAGCTGGGCGAGAGGCAGATTCACCATCTCCGAAACCTCCAAGAACACGGTGACTCTTCAAATGAACAGCCTGAGAGCCGAGGACTCGGCTGTGTATTACTGTGCGAGAAATCTTTACACTTACAATAGCTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 100: PD206F12 VH aa
EVQLVESGGGLVQPGGSLRLSCAASGFDFSSGYWICWVRQAPGKGLELIACIYAGTSGSTSYASWARGRFTISETSKNTVTLQMNSLRAEDSAVYYCARNLYTYNSLWGQGTLVTVSS
서열번호 101: PD206F12 VL nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATGATAACAACTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATACAGTATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCACTTATTATAGTAGTGGTTGGAACTTTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 102: PD206F12 VL aa
DIQMTQSPSTLSASVGDRVTITCQSSQSVYDNNWLAWYQQKPGKAPKLLIYTVSTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGTYYSSGWNFAFGGGTKVEIK
서열번호 103: PD215A1 VH nt
CAGGAGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGCCTCTGGATTCTCCTTTAGCAGCTACTGGATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTACGACTGGTAGTGGTAGCACTTACTACGCGAGCTGGGCGAAGCGCCGGTTCACCATCTCCAAAGACAATTCCAAGAACACGGTGACTCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTACGAGAGCATTTGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 104: PD215A1 VH aa
QEQLLESGGGLVQPGGSLRLSCTASGFSFSSYWMCWVRQAPGKGLEWIGCITTGSGSTYYASWAKRRFTISKDNSKNTVTLQMNSLRAEDTAVYYCTRAFDLWGQGTLVTVSS
서열번호 105: PD215A1 VL nt
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTTACAGCTACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGTCTGCAACCTGAAGATTTTGCAACTTACTACTGTCAAAGCAGTTGGTTGAGTGGTGCTGTTGGTAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 106: PD215A1 VL aa
DIQMTQSPSSLSASVGDRVTITCQASQSIYSYLNWYQQKPGKAPKLLIYGASNLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQSSWLSGAVGNAFGGGTKVEIK
서열번호 107: PD225G11 VH nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCAGCCACTGGATATGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTTATACTGGTAGTATTGATGTCTTTTACTACGCGAGCTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGCCGCTAATACTGATACTACCTACTTTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 108: PD225G11 VH aa
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSSHWICWVRQAPGKGLEWIACIYTGSIDVFYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARAANTDTTYFNLWGQGTLVTVSS
서열번호 109: PD225G11 VL nt
GCCTATGATATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAGGCCAGTCAGAGCATTAACAACCAACTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCACCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCATGTTCATTATTGCAGTGGTGGTAGTTGTTTTTGGGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 110: PD225G11 VL aa
AYDMTQSPSSLSASVGDRVTINCQASQSINNQLSWYQQKPGKVPKLLIYGASTLASGVPSRFTGSGSGTDFTLTISSLQPEDVATYYCHVHYCSGGSCFWAFGGGTKVEIK
서열번호 111: PL230C6 VH nt
CAGTCGGTGGAGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACCGCCTCTGGAATCGACCTTAATACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTTGGAATCATTACTTATAGTGGTAGTAGATACTACGCGAACTGGGCGAAAGGCCGATTCACCATCTCCAAAGACAATACCAAGAACACGGTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTATATGAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCC
서열번호 112: PL230C6 VH aa
QSVEESGGGLVQPGGSLRLSCTASGIDLNTYDMIWVRQAPGKGLEWVGIITYSGSRYYANWAKGRFTISKDNTKNTVYLQMNSLRAEDTAVYYCARDYMSGSHLWGQGTLVTVSS
서열번호 113: PL230C6 VL nt
GCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGTCAGGCCAGTGAGGACATTTATAGCTTCTTGGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCCATTCTGCATCCTCTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATGGTAAAAATAATGTTGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 114: PL230C6 VL aa
AYDMTQSPSSVSASVGDRVTIKCQASEDIYSFLAWYQQKPGKAPKLLIHSASSLASGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQGYGKNNVDNAFGGGTKVEIK
서열번호 115: PL231H2 VH nt
CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCCAGCCTGGGGGCTCCCTGAGACTCTCCTGTACAACTTCTGGAATCGACCTTAGTACCTACGACATGATCTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGGAATCATTAGTTATGTTGGTAACACATACTACGCGAGCTGGGCGAAAGGCCGATTCACCCTCTCCAAAGACAATACCTCGACCACGGTGGATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATTTTATTAGTGGTTCCCACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 116: PL231H2 VH aa
QVQLVESGGGLVQPGGSLRLSCTTSGIDLSTYDMIWVRQAPGKGLEWVGIISYVGNTYYASWAKGRFTLSKDNTSTTVDLQMNSLRAEDTAVYYCARDFISGSHLWGQGTLVTVSS
서열번호 117: PL231H2 VL nt
GCCTATGATATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGTCAGGCCAGTGAGAGCATTAGTAGCTTCTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTTTTCTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATTTTGCAACTTACTATTGTCAACAGGGTTATAGTAAAAGTAATGTGGATAATGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 118: PL231H2 VL aa
AYDMTQSPSSVSASVGDRVTINCQASESISSFLSWYQQKPGKAPKLLIFSASTLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGYSKSNVDNAFGGGTKVEIK
서열번호 119: PL221G5 VH nt
GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 120: PL221G5 VH aa
EVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS
서열번호 121: PL221G5 VL nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 122: PL221G5 VL aa
DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVEIK
서열번호 123: PL004B5 VH nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCCTCAGTAGCTACTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTGATACTAATGTTTATATATACTACGCGAACTGGGCAAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGATATGTGGGTAATAATGATGATTATATTAACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 124: PL004B5 VH aa
EVQLVESGGGLVQPGGSLRLSCAASGFSLSSYWMSWVRQAPGKGLEWIGVIDTNVYIYYANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYVGNNDDYINLWGQGTLVTVSS
서열번호 125: PL004B5 VL nt
GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCAGAGTGTTTATAATGGCTACTGGTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGGTGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCTAGGCAGTTATACTAGTAGTACTGAGAACTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 126: PL004B5 VL aa
DIQMTQSPSTLSASVGDRVTITCQSSQSVYNGYWLSWYQQKPGKAPKLLIYGASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCLGSYTSSTENSFGGGTKVEIK
서열번호 127: PL004B9 VH nt
GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACAGTGTCTGGAATCGACCTCAGTGTCATCAATATGGGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAACCATTACTTATGTTGGTAACACATATTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAAAACCTCGACCACGGTGGATCTTAAAATCACCAGTCCGACAACCGAGGACACGGCTGTGTATTACTGTGCGAGAGAATCTGGTACTATTTATTACAGTTACTTTAACTTGTGGGGCCAAGGGACCCTGGTCACCGTCTCGAGC
서열번호 128: PL004B9 VH aa
EVQLVESGGGLVQPGGSLRLSCTVSGIDLSVINMGWVRQAPGKGLEWIGTITYVGNTYYASWAKGRFTISKTSTTVDLKITSPTTEDTAVYYCARESGTIYYSYFNLWGQGTLVTVSS
서열번호 129: PL004B9 VL nt
GCATTCGAATTGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAAGTGCCAGGCCAGTGAAAGCATTAGCAACTACTTATCCTGGTATCAGCAGATTCCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCAATCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTCAAAGCTATTATGGTGGTGGTAGTGCCTATACTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 130: PL004B9 VL aa
AFELTQSPSSLSASVGDRVTIKCQASESISNYLSWYQQIPGKVPKLLIYYASNLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQSYYGGGSAYTFGGGTKVEIK
서열번호 131: PD220F6 VH nt
CAGGAGCAGGTGAAGGAGACCGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGCAGCTATGGAGTGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGCATTGATTTTTCCCGGGATTGGTTTCAAAGACTACGCGAGCTGGGTGAATGGCCGGTTCACCCTCTCCAGCGACAACGCCCAGAACACTGTGGAACTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGATTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC
서열번호 132: PD220F6 VH aa
QEQVKETGGGLVQPGGSLRLSCAASGFTISSYGVSWVRQAPGKGLEWVALIFPGIGFKDYASWVNGRFTLSSDNAQNTVELQMNSLRAEDTAVYYCARDLDLWGQGTLVTVSS
서열번호 133: PD220F6 VL nt
GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCCGAGTGTTTATAGTAACTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTGCAGGCGGTTATAGTAGTAGTACTCGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 134: PD220F6 VL aa
DIQMTQSPSSLSASVGDRVTITCQSSPSVYSNYLSWYQQKPGKVPKLLIYYASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCAGGYSSSTRAFGGGTKVEIK
서열번호 135: 인간 IgG1 불변 영역 nt
GCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGT
서열번호 136: 인간 IgG1 불변 영역 aa
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
서열번호 137: 인간 IgG1 효과기 널 nt
GCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGT
서열번호 138: 인간 IgG1 효과기 널 aa
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
서열번호 139: PD220F6 scFv nt
CAGGAGCAGGTGAAGGAGACCGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGCAGCTATGGAGTGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGCATTGATTTTTCCCGGGATTGGTTTCAAAGACTACGCGAGCTGGGTGAATGGCCGGTTCACCCTCTCCAGCGACAACGCCCAGAACACTGTGGAACTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGAGATTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGCGGCTCTGACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGTCCAGTCCGAGTGTTTATAGTAACTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGTTCCTAAGCTCCTGATCTATTATGCATCCACTCTGGCATCTGGGGTCCCATCTCGGTTCAGTGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAGCCTGCAGCCTGAAGATGTTGCAACTTATTACTGTGCAGGCGGTTATAGTAGTAGTACTCGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA
서열번호 140: PD220F6 scFv aa
QEQVKETGGGLVQPGGSLRLSCAASGFTISSYGVSWVRQAPGKGLEWVALIFPGIGFKDYASWVNGRFTLSSDNAQNTVELQMNSLRAEDTAVYYCARDLDLWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCQSSPSVYSNYLSWYQQKPGKVPKLLIYYASTLASGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCAGGYSSSTRAFGGGTKVEIK
서열번호 141: CT4 VH CDR1 aa
SSYTMH
서열번호 142: CT4 VH CDR2 aa
FISYDGNNKYYADSVKG
서열번호 143: CT4 VH CDR3 aa
TGWLGPFDY
서열번호 144: CT4 VL CDR1 aa
RASQSVGSSYLA
서열번호 145: CT4 VL CDR2 aa
GAFSRAT
서열번호 146: CT4 VL CDR3 aa
QQYGSSPWT
서열번호 147: PL230C6 VH CDR1 aa
NTYDMI
서열번호 148: PL230C6VH CDR2 aa
IITYSGSRYYANWAKG
서열번호 149: PL230C6VH CDR3 aa
DYMSGSHL
서열번호 150: PL230C6VL CDR1 aa
QASEDIYSFLA
서열번호 151: PL230C6VL CDR2 aa
SASSLAS
서열번호 152: PL230C6VL CDR3 aa
QQGYGKNNVDNA
서열번호 153: PD224D1 VH CDR1 aa
NTYDMI
서열번호 154: PD224D1 CDR2 aa
IITYSGSRYYANWAKG
서열번호 155: PD224D1 CDR3 aa
DYMSGSHL
서열번호 156: PD224D1 CDR1 aa
QASEDIYSFLA
서열번호 157: PD224D1 CDR2 aa
SASSLAS
서열번호 158: PD224D1 CDR3 aa
QQGYGKNNVDNA
서열번호 159: PL221G5 VH CDR1 aa
SGYDMC
서열번호 160: PL221G5 CDR2 aa
CIAAGSAGITYDANWAKG
서열번호 161: PL221G5 CDR3 aa
SAFSFDYAMDL
서열번호 162: PL221G5 CDR1 aa
QASQSISSHLN
서열번호 163: PL221G5 CDR2 aa
KASTLAS
서열번호 164: PL221G5 CDR3 aa
QQGYSWGNVDNV
서열번호 165: PL231H2 VH CDR1 aa
STYDMI
서열번호 166: PL231H2 VH CDR2 aa
IISYVGNTYYASWAKG
서열번호 167: PL231H2 VH CDR3 aa
DFISGSHL
서열번호 168: PL231H2 VL CDR1 aa
QASESISSFLS
서열번호 169: PL231H2 VL CDR2 aa
SASTLAS
서열번호 170: PL231H2 VL CDR3 aa
QQGYSKSNVDNA
서열번호 171: PL004B5 VH CDR1 aa
SSYWMS
서열번호 172: PL004B5 VH CDR2 aa
VIDTNVYIYYANWAKG
서열번호 173: PL004B5 VH CDR3 aa
YVGNNDDYINL
서열번호 174: PL004B5 VL CDR1 aa
QSSQSVYNGWLS
서열번호 175: PL004B5 VL CDR2 aa
GASTLAS
서열번호 176: PL004B5 VL CDR3 aa
LGSYTSSTENS
서열번호 177: PL004B9 VH CDR1 aa
SVINMG
서열번호 178: PL004B9 VH CDR2 aa
TITYVGNTYYASWAKG
서열번호 179: PL004B9 VH CDR3 aa
ESGTIYYSYFNL
서열번호 180: PL004B9 VL CDR1 aa
QASESISNYLS
서열번호 181: PL004B9 VL CDR2 aa
YASNLAS
서열번호 182: PL004B9 VL CDR3 aa
QSYYGGGSAYT
서열번호 183: PD206F12 VH CDR1 aa
SGYWIC
서열번호 184: PD206F12 VH CDR2 aa
CIYAGTSGSTSYASWARG
서열번호 185: PD206F12 VH CDR3 aa
NLYTYNSL
서열번호 186: PD206F12 VL CDR1 aa
QSSQSVYDNNWLA
서열번호 187: PD206F12 VL CDR2 aa
TVSTLAS
서열번호 188: PD206F12 VL CDR3 aa
QGTYYSSGWNFA
서열번호 189: PD215A1 VH CDR1 aa
SSYWMC
서열번호 190: PD215A1 VH CDR2 aa
CITTGSGSTYYASWAKR
서열번호 191: PD215A1 VH CDR3 aa
AFDL
서열번호 192: PD215A1 VL CDR1 aa
QASQSIYSYLN
서열번호 193: PD215A1 VL CDR2 aa
GASNLAS
서열번호 194: PD215A1 VL CDR3 aa
QSSWLSGAVGNA
서열번호 195: PD220F6 VH CDR1 aa
SSYGVS
서열번호 196: PD220F6 VH CDR2 aa
LIFPGIGFKDYASWVNG
서열번호 197: PD220F6 VH CDR3 aa
DLDL
서열번호 198: PD220F6 VL CDR1 aa
QSSPSVYSNYLS
서열번호 199: PD220F6 VL CDR2 aa
YASTLAS
서열번호 200: PD220F6 VL CDR3 aa
AGGYSSSTRA
서열번호 201: PD225G11 VH CDR1 aa
SSHWIC
서열번호 202: PD225G11 VH CDR2 aa
CIYTGSIDVFYYASWAKG
서열번호 203: PD225G11 VH CDR3 aa
AANTDTTYFNL
서열번호 204: PD225G11 VL CDR1 aa
QASQSINNQLS
서열번호 205: PD225G11 VL CDR2 aa
GASTLAS
서열번호 206: PD225G11 VL CDR3 aa
HVHYCSGGSCFWA
SEQUENCE LISTING <110> SYSTIMMUNE, INC. SICHUAN BAILI PHARM CO., LTD. <120> BISPECIFIC ANTIBODIES AND METHODS OF MAKING AND USING THEREOF <130> IPA191696-US <150> US 62/580,845 <151> 2017-11-02 <160> 206 <170> PatentIn version 3.5 <210> 1 <211> 2103 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 1 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc cgaggtgcag 1380 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtaca 1440 gcctctggat tctccctcag tagctatgca atgagctggg tccgccaggc tccagggaag 1500 gggctggagt acatcggcta cattggtgat actactggca tagcctacgc gagctgggcg 1560 aatggcagat tcaccatctc caaagacaat accaagaaca cggtggatct tcaaatgaac 1620 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gaggctggtc ctacttagac 1680 atctggggcc aagggaccct ggtcaccgtc tcgagcggtg gaggcggatc tggcggaggt 1740 ggttccggcg gtggcggctc cggtggaggc ggctctgccc ttgtgatgac ccagtctcca 1800 tcctccctgt ctgcatctgt aggagacaga gtcaccatca cttgccaggc cagtcagaac 1860 atttacagca atttagcctg gtatcagcag aaaccaggga aagttcctaa gctcctgatc 1920 tatcaggcct ccactctggc atctggggtc ccatctcggt tcagtggcag tggatatggg 1980 acagatttca ctctcaccat cagcagcctg cagcctgaag atgttgcaac ttattactgt 2040 caaggcggtt attatagtgc tgcccttaat actttcggcg gagggaccaa ggtggagatc 2100 aaa 2103 <210> 2 <211> 701 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 2 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 465 470 475 480 Ala Ser Gly Phe Ser Leu Ser Ser Tyr Ala Met Ser Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Tyr Ile Gly Asp Thr Thr 500 505 510 Gly Ile Ala Tyr Ala Ser Trp Ala Asn Gly Arg Phe Thr Ile Ser Lys 515 520 525 Asp Asn Thr Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala 530 535 540 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Trp Ser Tyr Leu Asp 545 550 555 560 Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 565 570 575 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 580 585 590 Ala Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 595 600 605 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 610 615 620 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 625 630 635 640 Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 645 650 655 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 660 665 670 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ala Ala 675 680 685 Leu Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 3 <211> 645 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 3 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc 300 caagggacca aggtggaaat caaacgtacg gtggctgcac catctgtctt catcttcccg 360 ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 420 tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 480 caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 540 acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 600 ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt 645 <210> 4 <211> 215 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 4 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 5 <211> 2106 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 5 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc ccagtcggtg 1380 gaggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtaccgcc 1440 tctggaatcg accttaatac ctacgacatg atctgggtcc gccaggctcc aggcaagggg 1500 ctagagtggg ttggaatcat tacttatagt ggtagtagat actacgcgaa ctgggcgaaa 1560 ggccgattca ccatctccaa agacaatacc aagaacacgg tgtatctgca aatgaacagc 1620 ctgagagctg aggacacggc tgtgtattac tgtgcgagag attatatgag tggttcccac 1680 ttgtggggcc agggaaccct ggtcaccgtc tcttccggtg gaggcggttc aggcggaggt 1740 ggaagtggtg gtggcggctc tggaggcggc ggatctgcct atgatatgac ccagtctcca 1800 tcttccgtgt ctgcatctgt aggagacaga gtcaccatca agtgtcaggc cagtgaggac 1860 atttatagct tcttggcctg gtatcagcag aaaccaggga aagcccctaa gctcctgatc 1920 cattctgcat cctctctggc atctggggtc ccatcaaggt tcagcggcag tggatctggg 1980 acagatttca ctctcaccat cagcagcctg cagcctgaag attttgcaac ttactattgt 2040 caacagggtt atggtaaaaa taatgttgat aatgctttcg gcggagggac caaggtggag 2100 atcaaa 2106 <210> 6 <211> 702 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 6 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Glu Glu Ser Gly 450 455 460 Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 465 470 475 480 Ser Gly Ile Asp Leu Asn Thr Tyr Asp Met Ile Trp Val Arg Gln Ala 485 490 495 Pro Gly Lys Gly Leu Glu Trp Val Gly Ile Ile Thr Tyr Ser Gly Ser 500 505 510 Arg Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Asp 515 520 525 Asn Thr Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 530 535 540 Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Met Ser Gly Ser His 545 550 555 560 Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 565 570 575 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 580 585 590 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 595 600 605 Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Tyr Ser Phe 610 615 620 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 625 630 635 640 His Ser Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 645 650 655 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 660 665 670 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Lys Asn Asn 675 680 685 Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 7 <211> 2127 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 7 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc cgaggtgcag 1380 ctgttggagt ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca 1440 gcctctggat tctccttcag tagcgggtac gacatgtgct gggtccgcca ggctccaggg 1500 aaggggctgg agtggatcgc atgcattgct gctggtagtg ctggtatcac ttacgacgcg 1560 aactgggcga aaggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 1620 caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgag atcggcgttt 1680 tcgttcgact acgccatgga cctctggggc cagggaaccc tggtcaccgt ctcgagcggt 1740 ggaggcggat ctggcggagg tggttccggc ggtggcggct ccggtggagg cggctctgac 1800 atccagatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 1860 acttgccagg ccagtcagag cattagttcc cacttaaact ggtatcagca gaaaccaggg 1920 aaagccccta agctcctgat ctataaggca tccactctgg catctggggt cccatcaagg 1980 ttcagcggca gtggatctgg gacagaattt actctcacca tcagcagcct gcagcctgat 2040 gattttgcaa cttattactg ccaacagggt tatagttggg gtaatgttga taatgttttc 2100 ggcggaggga ccaaggtgga gatcaaa 2127 <210> 8 <211> 709 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 8 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg 485 490 495 Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly 500 505 510 Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr 515 520 525 Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 530 535 540 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe 545 550 555 560 Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr 565 570 575 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 580 585 590 Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser 595 600 605 Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 610 615 620 Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly 625 630 635 640 Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly 645 650 655 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 660 665 670 Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln 675 680 685 Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr 690 695 700 Lys Val Glu Ile Lys 705 <210> 9 <211> 2109 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 9 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc acaggtgcag 1380 ctggtggagt ctgggggagg cctggtccag cctgggggct ccctgagact ctcctgtaca 1440 acttctggaa tcgaccttag tacctacgac atgatctggg tccgccaggc tccaggcaag 1500 gggctagagt gggtgggaat cattagttat gttggtaaca catactacgc gagctgggcg 1560 aaaggccgat tcaccctctc caaagacaat acctcgacca cggtggatct gcaaatgaac 1620 agcctgagag ctgaggacac ggctgtgtat tactgtgcga gagattttat tagtggttcc 1680 cacttgtggg gccagggaac cctggtcacc gtctcgagcg gtggaggcgg atctggcgga 1740 ggtggttccg gcggtggcgg ctccggtgga ggcggttctg cctatgatat gacccagtct 1800 ccatcttccg tgtctgcatc tgtaggagac agagtcacca tcaattgtca ggccagtgag 1860 agcattagta gcttcttatc ctggtatcag cagaaaccag ggaaagcccc taagctcctg 1920 atcttttctg catccactct ggcatctggg gtcccatcaa ggttcagcgg cagtggatct 1980 gggacagatt tcactctcac catcagcagc ctgcagcctg aagattttgc aacttactat 2040 tgtcaacagg gttatagtaa aagtaatgtg gataatgctt tcggcggagg gaccaaggtg 2100 gagatcaaa 2109 <210> 10 <211> 703 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 10 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 465 470 475 480 Thr Ser Gly Ile Asp Leu Ser Thr Tyr Asp Met Ile Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Ile Ile Ser Tyr Val Gly 500 505 510 Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Leu Ser Lys 515 520 525 Asp Asn Thr Ser Thr Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala 530 535 540 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Phe Ile Ser Gly Ser 545 550 555 560 His Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 565 570 575 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 580 585 590 Ser Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val 595 600 605 Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser 610 615 620 Phe Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 625 630 635 640 Ile Phe Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 645 650 655 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 660 665 670 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Lys Ser 675 680 685 Asn Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 11 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 11 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc agaggtgcag 1380 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 1440 gcctctggat tctccctcag tagctactgg atgagctggg tccgccaggc tccagggaag 1500 gggctggagt ggatcggagt cattgatact aatgtttata tatactacgc gaactgggca 1560 aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1620 agcctgagag ccgaggacac ggctgtgtat tactgtgcga gatatgtggg taataatgat 1680 gattatatta acttgtgggg ccagggaacc ctggtcaccg tctcgagcgg tggaggcgga 1740 tctggcggag gtggttccgg cggtggcggc tccggtggag gcggctctga catccagatg 1800 acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat cacttgccag 1860 tccagtcaga gtgtttataa tggctactgg ttatcctggt atcagcagaa accagggaaa 1920 gcccctaagc tcctgatcta tggtgcatcc actctggcat ctggggtccc atcaaggttc 1980 agcggcagtg gatctgggac agaattcact ctcaccatca gcagcctgca gcctgatgat 2040 tttgcaactt attactgcct aggcagttat actagtagta ctgagaactc tttcggcgga 2100 gggaccaagg tggagatcaa a 2121 <210> 12 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 12 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Ser Leu Ser Ser Tyr Trp Met Ser Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Asp Thr Asn Val 500 505 510 Tyr Ile Tyr Tyr Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg 515 520 525 Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 530 535 540 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Val Gly Asn Asn Asp 545 550 555 560 Asp Tyr Ile Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 565 570 575 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 580 585 590 Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser 595 600 605 Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser 610 615 620 Val Tyr Asn Gly Tyr Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 625 630 635 640 Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val 645 650 655 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr 660 665 670 Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly 675 680 685 Ser Tyr Thr Ser Ser Thr Glu Asn Ser Phe Gly Gly Gly Thr Lys Val 690 695 700 Glu Ile Lys 705 <210> 13 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 13 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc agaggtgcag 1380 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtaca 1440 gtgtctggaa tcgacctcag tgtcatcaat atgggctggg tccgccaggc tccagggaag 1500 gggctggagt ggatcggaac cattacttat gttggtaaca catattacgc gagctgggcg 1560 aaaggcagat tcaccatctc caaaacctcg accacggtgg atcttaaaat caccagtccg 1620 acaaccgagg acacggctgt gtattactgt gcgagagaat ctggtactat ttattacagt 1680 tactttaact tgtggggcca agggaccctg gtcaccgtct cgagcggtgg aggcggatct 1740 ggcggaggtg gttccggcgg tggcggctcc ggtggaggcg gctctgcatt cgaattgacc 1800 cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcaa gtgccaggcc 1860 agtgaaagca ttagcaacta cttatcctgg tatcagcaga ttccagggaa agttcctaag 1920 ctcctgatct attatgcatc caatctggca tctggggtcc catctcggtt cagtggcagt 1980 ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga tgttgcaact 2040 tattactgtc aaagctatta tggtggtggt agtgcctata ctttcggcgg agggaccaag 2100 gtggagatca aa 2112 <210> 14 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 14 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 465 470 475 480 Val Ser Gly Ile Asp Leu Ser Val Ile Asn Met Gly Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Thr Ile Thr Tyr Val Gly 500 505 510 Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys 515 520 525 Thr Ser Thr Thr Val Asp Leu Lys Ile Thr Ser Pro Thr Thr Glu Asp 530 535 540 Thr Ala Val Tyr Tyr Cys Ala Arg Glu Ser Gly Thr Ile Tyr Tyr Ser 545 550 555 560 Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 580 585 590 Gly Gly Ser Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala 595 600 605 Ser Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile 610 615 620 Ser Asn Tyr Leu Ser Trp Tyr Gln Gln Ile Pro Gly Lys Val Pro Lys 625 630 635 640 Leu Leu Ile Tyr Tyr Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg 645 650 655 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 660 665 670 Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly 675 680 685 Gly Gly Ser Ala Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 15 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 15 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc agaggtgcag 1380 ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 1440 gcctctggat tcgacttcag tagcggctac tggatatgct gggtccgcca ggctccaggg 1500 aaggggctgg agttgatcgc atgcatttat gctggtacta gtggtagtac ttcctacgcg 1560 agctgggcga gaggcagatt caccatctcc gaaacctcca agaacacggt gactcttcaa 1620 atgaacagcc tgagagccga ggactcggct gtgtattact gtgcgagaaa tctttacact 1680 tacaatagct tgtggggcca gggaaccctg gtcaccgtct cgagcggtgg aggcggatct 1740 ggcggaggtg gttccggcgg tggcggctcc ggtggaggcg gctctgacat ccagatgacc 1800 cagtctcctt ccaccctgtc tgcatctgta ggagacagag tcaccatcac ttgccagtcc 1860 agtcagagtg tttatgataa caactggtta gcctggtatc agcagaaacc agggaaagcc 1920 cctaagctcc tgatctatac agtatccact ctggcatctg gggtcccatc aaggttcagc 1980 ggcagtggat ctgggacaga attcactctc accatcagca gcctgcagcc tgatgatttt 2040 gcaacttatt actgccaagg cacttattat agtagtggtt ggaactttgc tttcggcgga 2100 gggaccaagg tggagatcaa a 2121 <210> 16 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 16 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Asp Phe Ser Ser Gly Tyr Trp Ile Cys Trp Val Arg 485 490 495 Gln Ala Pro Gly Lys Gly Leu Glu Leu Ile Ala Cys Ile Tyr Ala Gly 500 505 510 Thr Ser Gly Ser Thr Ser Tyr Ala Ser Trp Ala Arg Gly Arg Phe Thr 515 520 525 Ile Ser Glu Thr Ser Lys Asn Thr Val Thr Leu Gln Met Asn Ser Leu 530 535 540 Arg Ala Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Thr 545 550 555 560 Tyr Asn Ser Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 580 585 590 Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala 595 600 605 Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val 610 615 620 Tyr Asp Asn Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 625 630 635 640 Pro Lys Leu Leu Ile Tyr Thr Val Ser Thr Leu Ala Ser Gly Val Pro 645 650 655 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 660 665 670 Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr 675 680 685 Tyr Tyr Ser Ser Gly Trp Asn Phe Ala Phe Gly Gly Gly Thr Lys Val 690 695 700 Glu Ile Lys 705 <210> 17 <211> 2100 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 17 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc acaggagcag 1380 ctgttggagt ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtaca 1440 gcctctggat tctcctttag cagctactgg atgtgctggg tccgccaggc tccagggaag 1500 gggctggagt ggatcggatg cattacgact ggtagtggta gcacttacta cgcgagctgg 1560 gcgaagcgcc ggttcaccat ctccaaagac aattccaaga acacggtgac tctgcaaatg 1620 aacagcctga gagccgagga cacggccgta tattactgta cgagagcatt tgacttgtgg 1680 ggccagggaa ccctggtcac cgtctcgagc ggtggaggcg gatctggcgg aggtggttcc 1740 ggcggtggcg gctccggtgg aggcggctct gacatccaga tgacccagtc tccatcctcc 1800 ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc aggccagtca gagcatttac 1860 agctacttaa actggtatca gcagaaacca gggaaagccc ctaagctcct gatctatggt 1920 gcatccaatc tggcatctgg ggtcccatca aggttcagtg gcagtggatc tgggacagat 1980 ttcactctca ccatcagcag tctgcaacct gaagattttg caacttacta ctgtcaaagc 2040 agttggttga gtggtgctgt tggtaatgct ttcggcggag ggaccaaggt ggagatcaaa 2100 <210> 18 <211> 700 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 18 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Leu Leu Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr 465 470 475 480 Ala Ser Gly Phe Ser Phe Ser Ser Tyr Trp Met Cys Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Cys Ile Thr Thr Gly Ser 500 505 510 Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys Arg Arg Phe Thr Ile Ser 515 520 525 Lys Asp Asn Ser Lys Asn Thr Val Thr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg Ala Phe Asp Leu Trp 545 550 555 560 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 580 585 590 Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 595 600 605 Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr Leu Asn 610 615 620 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly 625 630 635 640 Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 645 650 655 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 660 665 670 Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Trp Leu Ser Gly Ala Val Gly 675 680 685 Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 19 <211> 2097 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 19 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc acaggagcag 1380 gtgaaggaga ccgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca 1440 gcctctggat tcaccatcag cagctatgga gtgagctggg tccgccaggc tccagggaag 1500 gggctggagt gggtcgcatt gatttttccc gggattggtt tcaaagacta cgcgagctgg 1560 gtgaatggcc ggttcaccct ctccagcgac aacgcccaga acactgtgga actgcaaatg 1620 aacagcctga gagccgagga cacggccgta tattactgtg cgagagattt ggacttgtgg 1680 ggccagggaa ccctggtcac cgtctcgagc ggtggaggcg gatctggcgg aggtggttcc 1740 ggcggtggcg gctccggtgg aggcggctct gacatccaga tgacccagtc tccatcctcc 1800 ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc agtccagtcc gagtgtttat 1860 agtaactact tatcctggta tcagcagaaa ccagggaaag ttcctaagct cctgatctat 1920 tatgcatcca ctctggcatc tggggtccca tctcggttca gtggcagtgg atctgggaca 1980 gatttcactc tcaccatcag cagcctgcag cctgaagatg ttgcaactta ttactgtgca 2040 ggcggttata gtagtagtac tcgtgctttc ggcggaggga ccaaggtgga gatcaaa 2097 <210> 20 <211> 699 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 20 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu Gln Val Lys Glu Thr 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Ile Ser Ser Tyr Gly Val Ser Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Phe Pro Gly Ile 500 505 510 Gly Phe Lys Asp Tyr Ala Ser Trp Val Asn Gly Arg Phe Thr Leu Ser 515 520 525 Ser Asp Asn Ala Gln Asn Thr Val Glu Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Asp Leu Trp 545 550 555 560 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 580 585 590 Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 595 600 605 Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Tyr Ser Asn Tyr Leu 610 615 620 Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr 625 630 635 640 Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 660 665 670 Asp Val Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Ser Thr Arg 675 680 685 Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 690 695 <210> 21 <211> 2130 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 21 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctcagctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc agaggtgcag 1380 ctgttggagt ctgggggagg cttggtacag cctggggggt ccctgagact ctcctgtgca 1440 gcctctggat tcacctttag cagcagccac tggatatgct gggtccgcca ggctccaggg 1500 aaggggctgg agtggatcgc atgcatttat actggtagta ttgatgtctt ttactacgcg 1560 agctgggcga aaggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 1620 caaatgaaca gcctgagagc cgaggacacg gccgtatatt actgtgcgag agccgctaat 1680 actgatacta cctactttaa cttgtggggc cagggaaccc tggtcaccgt ctcgagcggt 1740 ggaggcggat ctggcggagg tggttccggc ggtggcggct ccggtggagg cggctctgcc 1800 tatgatatga cccagtctcc atcctccctg tctgcatctg taggagacag agtcaccatc 1860 aattgccagg ccagtcagag cattaacaac caactatcct ggtatcagca gaaaccaggg 1920 aaagttccta agctcctgat ctatggtgca tccactctgg catctggggt cccatctcgg 1980 ttcaccggca gtggatctgg gacagatttc actctcacca tcagcagcct gcagcctgaa 2040 gatgttgcaa cttattactg tcatgttcat tattgcagtg gtggtagttg tttttgggct 2100 ttcggcggag ggaccaaggt ggagatcaaa 2130 <210> 22 <211> 710 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 22 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 450 455 460 Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Ser Ser Ser His Trp Ile Cys Trp Val Arg 485 490 495 Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Tyr Thr Gly 500 505 510 Ser Ile Asp Val Phe Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr 515 520 525 Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 530 535 540 Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ala Ala Asn 545 550 555 560 Thr Asp Thr Thr Tyr Phe Asn Leu Trp Gly Gln Gly Thr Leu Val Thr 565 570 575 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 580 585 590 Gly Ser Gly Gly Gly Gly Ser Ala Tyr Asp Met Thr Gln Ser Pro Ser 595 600 605 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala 610 615 620 Ser Gln Ser Ile Asn Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly 625 630 635 640 Lys Val Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly 645 650 655 Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 660 665 670 Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys His 675 680 685 Val His Tyr Cys Ser Gly Gly Ser Cys Phe Trp Ala Phe Gly Gly Gly 690 695 700 Thr Lys Val Glu Ile Lys 705 710 <210> 23 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 23 ggtggaggcg gatctggcgg aggtggttcc ggcggtggcg gctccggtgg aggcggctct 60 <210> 24 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 24 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 1 5 10 15 Gly Gly Gly Ser 20 <210> 25 <211> 2100 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 25 cagtcggtgg aggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc 60 tgtaccgcct ctggaatcga ccttaatacc tacgacatga tctgggtccg ccaggctcca 120 ggcaaggggc tagagtgggt tggaatcatt acttatagtg gtagtagata ctacgcgaac 180 tgggcgaaag gccgattcac catctccaaa gacaatacca agaacacggt gtatctgcaa 240 atgaacagcc tgagagctga ggacacggct gtgtattact gtgcgagaga ttatatgagt 300 ggttcccact tgtggggcca gggaaccctg gtcaccgtct cgagcgctag caccaagggc 360 ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 420 ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc 480 ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 540 agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 600 aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa 660 actcacacat gcccaccgtg cccagcacct gaagccgcgg gggcaccgtc agtcttcctc 720 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 780 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 840 gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 900 gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcgcg 960 gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 1020 ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1080 gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1140 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1200 tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1260 ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1320 ctgtctccgg gtggcggtgg agggtccggc ggtggtggat cccaggtgca attggtggag 1380 tctgggggag gcgtggtcca gcctgggagg tccctgagac tctcctgtgc agcctctgga 1440 ttcaccttca gtagctatac tatgcactgg gtccgccagg ctccaggcaa ggggctggag 1500 tgggtgacat ttatatcata tgatggaaac aataaatact acgcagactc cgtgaagggc 1560 cgattcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg 1620 agagctgagg acacggctat atattactgt gcgaggaccg gctggctggg gccctttgac 1680 tactggggcc agggaaccct ggtcaccgtc tcgagcggtg gaggcggttc aggcggaggt 1740 ggaagtggtg gtggcggctc tggaggcggc ggatctgaaa ttgtgttgac gcagtctcca 1800 ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt 1860 gttggcagca gctacttagc ctggtaccag cagaaacctg gccaggctcc caggctcctc 1920 atctatggtg cattcagcag ggccactggc atcccagaca ggttcagtgg cagtgggtct 1980 gggacagact tcactctcac catcagcaga ctggagcctg aagattttgc agtgtattac 2040 tgtcagcagt atggtagctc accgtggacg ttcggccaag ggaccaaggt ggaaatcaaa 2100 <210> 26 <211> 700 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 26 Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Asp Leu Asn Thr Tyr Asp 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 35 40 45 Ile Ile Thr Tyr Ser Gly Ser Arg Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Asp Tyr Met Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 115 120 125 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 130 135 140 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 145 150 155 160 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 165 170 175 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 180 185 190 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 195 200 205 Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 450 455 460 Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 465 470 475 480 Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 485 490 495 Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys 500 505 510 Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 515 520 525 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 530 535 540 Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp 545 550 555 560 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 565 570 575 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 580 585 590 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 595 600 605 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 610 615 620 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 625 630 635 640 Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 645 650 655 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 660 665 670 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 675 680 685 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 27 <211> 651 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 27 gcctatgata tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcaagtgtc aggccagtga ggacatttat agcttcttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatccattct gcatcctctc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag ggttatggta aaaataatgt tgataatgct 300 ttcggcggag ggaccaaggt ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc 360 ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 420 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 480 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 540 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 <210> 28 <211> 217 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 28 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Tyr Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 His Ser Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Lys Asn Asn 85 90 95 Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 29 <211> 2100 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 29 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgccaggct 120 ccagggaagg ggctggagta catcggctac attggtgata ctactggcat agcctacgcg 180 agctgggcga atggcagatt caccatctcc aaagacaata ccaagaacac ggtggatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggctggtcc 300 tacttagaca tctggggcca agggaccctg gtcaccgtct cgagcgctag caccaagggc 360 ccatcggtct tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg 420 ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc 480 ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc 540 agcagcgtgg tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg 600 aatcacaagc ccagcaacac caaggtggac aagagagttg agcccaaatc ttgtgacaaa 660 actcacacat gcccaccgtg cccagcacct gaagccgcgg gggcaccgtc agtcttcctc 720 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 780 gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 840 gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 900 gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcgcg 960 gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 1020 ccccgagaac cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag 1080 gtcagcctga cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag 1140 agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1200 tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1260 ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1320 ctgtctccgg gtggcggtgg agggtccggc ggtggtggat cccaggtgca attggtggag 1380 tctgggggag gcgtggtcca gcctgggagg tccctgagac tctcctgtgc agcctctgga 1440 ttcaccttca gtagctatac tatgcactgg gtccgccagg ctccaggcaa ggggctggag 1500 tgggtgacat ttatatcata tgatggaaac aataaatact acgcagactc cgtgaagggc 1560 cgattcacca tctccagaga caattccaag aacacgctgt atctgcaaat gaacagcctg 1620 agagctgagg acacggctat atattactgt gcgaggaccg gctggctggg gccctttgac 1680 tactggggcc agggaaccct ggtcaccgtc tcgagcggtg gaggcggatc tggcggaggt 1740 ggttccggcg gtggcggctc cggtggaggc ggttctgaaa ttgtgttgac gcagtctcca 1800 ggcaccctgt ctttgtctcc aggggaaaga gccaccctct cctgcagggc cagtcagagt 1860 gttggcagca gctacttagc ctggtaccag cagaaacctg gccaggctcc caggctcctc 1920 atctatggtg cattcagcag ggccactggc atcccagaca ggttcagtgg cagtgggtct 1980 gggacagact tcactctcac catcagcaga ctggagcctg aagattttgc agtgtattac 2040 tgtcagcagt atggtagctc accgtggacg ttcggccaag ggaccaaggt ggaaatcaaa 2100 <210> 30 <211> 700 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 30 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Tyr Ile Gly Asp Thr Thr Gly Ile Ala Tyr Ala Ser Trp Ala Asn 50 55 60 Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Trp Ser Tyr Leu Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 115 120 125 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 130 135 140 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 145 150 155 160 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 165 170 175 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 180 185 190 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 195 200 205 Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 435 440 445 Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 450 455 460 Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 465 470 475 480 Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly 485 490 495 Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys 500 505 510 Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 515 520 525 Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 530 535 540 Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp 545 550 555 560 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 565 570 575 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 580 585 590 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 595 600 605 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 610 615 620 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 625 630 635 640 Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 645 650 655 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 660 665 670 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 675 680 685 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 31 <211> 648 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 31 gcccttgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gaacatttac agcaatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatcag gcctccactc tggcatctgg ggtcccatct 180 cggttcagtg gcagtggata tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaggc ggttattata gtgctgccct taatactttc 300 ggcggaggga ccaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc 360 ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 420 ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 480 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 540 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 600 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt 648 <210> 32 <211> 216 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 32 Ala Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ala Ala 85 90 95 Leu Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 100 105 110 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 115 120 125 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 130 135 140 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 145 150 155 160 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 165 170 175 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 180 185 190 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 195 200 205 Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 33 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 33 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt agcgggtacg acatgtgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcattgctg ctggtagtgc tggtatcact 180 tacgacgcga actgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 tcggcgtttt cgttcgacta cgccatggac ctctggggcc agggaaccct ggtcaccgtc 360 tcgagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420 tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480 gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540 tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600 cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt 660 gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 720 ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960 ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 1260 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320 tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 1380 tcccaggtgc aattggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga 1440 ctctcctgtg cagcctctgg attcaccttc agtagctata ctatgcactg ggtccgccag 1500 gctccaggca aggggctgga gtgggtgaca tttatatcat atgatggaaa caataaatac 1560 tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg 1620 tatctgcaaa tgaacagcct gagagctgag gacacggcta tatattactg tgcgaggacc 1680 ggctggctgg ggccctttga ctactggggc cagggaaccc tggtcaccgt ctcgagcggt 1740 ggaggcggat ctggcggagg tggttccggc ggtggcggct ccggtggagg cggttctgaa 1800 attgtgttga cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc 1860 tcctgcaggg ccagtcagag tgttggcagc agctacttag cctggtacca gcagaaacct 1920 ggccaggctc ccaggctcct catctatggt gcattcagca gggccactgg catcccagac 1980 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 2040 gaagattttg cagtgtatta ctgtcagcag tatggtagct caccgtggac gttcggccaa 2100 gggaccaagg tggaaatcaa a 2121 <210> 34 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 34 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 225 230 235 240 Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 450 455 460 Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 465 470 475 480 Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His 485 490 495 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile 500 505 510 Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 515 520 525 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 530 535 540 Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr 545 550 555 560 Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 565 570 575 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 580 585 590 Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 595 600 605 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 610 615 620 Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 625 630 635 640 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr 645 650 655 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 660 665 670 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 675 680 685 Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 690 695 700 Glu Ile Lys 705 <210> 35 <211> 651 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 35 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 300 ttcggcggag ggaccaaggt ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc 360 ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 420 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 480 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 540 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 <210> 36 <211> 217 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 36 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 37 <211> 2103 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 37 caggtgcagc tggtggagtc tgggggaggc ctggtccagc ctgggggctc cctgagactc 60 tcctgtacaa cttctggaat cgaccttagt acctacgaca tgatctgggt ccgccaggct 120 ccaggcaagg ggctagagtg ggtgggaatc attagttatg ttggtaacac atactacgcg 180 agctgggcga aaggccgatt caccctctcc aaagacaata cctcgaccac ggtggatctg 240 caaatgaaca gcctgagagc tgaggacacg gctgtgtatt actgtgcgag agattttatt 300 agtggttccc acttgtgggg ccagggaacc ctggtcaccg tctcgagcgc tagcaccaag 360 ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 420 ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 480 gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 540 ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 600 gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 660 aaaactcaca catgcccacc gtgcccagca cctgaagccg cgggggcacc gtcagtcttc 720 ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 780 gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 840 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 900 gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 960 gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1020 cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac 1080 caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1140 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1200 ggctccttct tcctctatag caagctcacc gtggacaaga gcaggtggca gcaggggaac 1260 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 1320 tccctgtctc cgggtggcgg tggagggtcc ggcggtggtg gatcccaggt gcaattggtg 1380 gagtctgggg gaggcgtggt ccagcctggg aggtccctga gactctcctg tgcagcctct 1440 ggattcacct tcagtagcta tactatgcac tgggtccgcc aggctccagg caaggggctg 1500 gagtgggtga catttatatc atatgatgga aacaataaat actacgcaga ctccgtgaag 1560 ggccgattca ccatctccag agacaattcc aagaacacgc tgtatctgca aatgaacagc 1620 ctgagagctg aggacacggc tatatattac tgtgcgagga ccggctggct ggggcccttt 1680 gactactggg gccagggaac cctggtcacc gtctcgagcg gtggaggcgg atctggcgga 1740 ggtggttccg gcggtggcgg ctccggtgga ggcggttctg aaattgtgtt gacgcagtct 1800 ccaggcaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag 1860 agtgttggca gcagctactt agcctggtac cagcagaaac ctggccaggc tcccaggctc 1920 ctcatctatg gtgcattcag cagggccact ggcatcccag acaggttcag tggcagtggg 1980 tctgggacag acttcactct caccatcagc agactggagc ctgaagattt tgcagtgtat 2040 tactgtcagc agtatggtag ctcaccgtgg acgttcggcc aagggaccaa ggtggaaatc 2100 aaa 2103 <210> 38 <211> 701 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 38 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ile Asp Leu Ser Thr Tyr 20 25 30 Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Ser Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Leu Ser Lys Asp Asn Thr Ser Thr Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Phe Ile Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 115 120 125 Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 130 135 140 Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 145 150 155 160 Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 165 170 175 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 180 185 190 Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 195 200 205 Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 260 265 270 Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly 435 440 445 Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 450 455 460 Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 465 470 475 480 Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro 485 490 495 Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn 500 505 510 Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 515 520 525 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 530 535 540 Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe 545 550 555 560 Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 565 570 575 Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 580 585 590 Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro 595 600 605 Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser 610 615 620 Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 625 630 635 640 Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe 645 650 655 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu 660 665 670 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser 675 680 685 Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 39 <211> 651 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 39 gcctatgata tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcaattgtc aggccagtga gagcattagt agcttcttat cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatcttttct gcatccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag ggttatagta aaagtaatgt ggataatgct 300 ttcggcggag ggaccaaggt ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc 360 ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 420 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 480 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 540 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 <210> 40 <211> 217 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 40 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Phe 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Phe Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Lys Ser Asn 85 90 95 Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 41 <211> 2112 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 41 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccctcagt agctactgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggagtc attgatacta atgtttatat atactacgcg 180 aactgggcaa aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag atatgtgggt 300 aataatgatg attatattaa cttgtggggc cagggaaccc tggtcaccgt ctcgagcgct 360 agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540 ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 660 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc gggggcaccg 720 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960 tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg 1080 accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200 gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 1260 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320 aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atcccaggtg 1380 caattggtgg agtctggggg aggcgtggtc cagcctggga ggtccctgag actctcctgt 1440 gcagcctctg gattcacctt cagtagctat actatgcact gggtccgcca ggctccaggc 1500 aaggggctgg agtgggtgac atttatatca tatgatggaa acaataaata ctacgcagac 1560 tccgtgaagg gccgattcac catctccaga gacaattcca agaacacgct gtatctgcaa 1620 atgaacagcc tgagagctga ggacacggct atatattact gtgcgaggac cggctggctg 1680 gggccctttg actactgggg ccagggaacc ctggtcaccg tctcgagcgg tggaggcgga 1740 tctggcggag gtggttccgg cggtggcggc tccggtggag gcggttctga aattgtgttg 1800 acgcagtctc caggcaccct gtctttgtct ccaggggaaa gagccaccct ctcctgcagg 1860 gccagtcaga gtgttggcag cagctactta gcctggtacc agcagaaacc tggccaggct 1920 cccaggctcc tcatctatgg tgcattcagc agggccactg gcatcccaga caggttcagt 1980 ggcagtgggt ctgggacaga cttcactctc accatcagca gactggagcc tgaagatttt 2040 gcagtgtatt actgtcagca gtatggtagc tcaccgtgga cgttcggcca agggaccaag 2100 gtggaaatca aa 2112 <210> 42 <211> 704 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 42 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Asp Thr Asn Val Tyr Ile Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Tyr Val Gly Asn Asn Asp Asp Tyr Ile Asn Leu Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 450 455 460 Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys 465 470 475 480 Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg 485 490 495 Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp 500 505 510 Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 515 520 525 Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 530 535 540 Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu 545 550 555 560 Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 565 570 575 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 580 585 590 Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser 595 600 605 Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 610 615 620 Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 625 630 635 640 Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro 645 650 655 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 660 665 670 Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 675 680 685 Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 43 <211> 654 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 43 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca gagtgtttat aatggctact ggttatcctg gtatcagcag 120 aaaccaggga aagcccctaa gctcctgatc tatggtgcat ccactctggc atctggggtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcaccat cagcagcctg 240 cagcctgatg attttgcaac ttattactgc ctaggcagtt atactagtag tactgagaac 300 tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 360 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 420 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 480 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 540 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 600 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt 654 <210> 44 <211> 218 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 44 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asn Gly 20 25 30 Tyr Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Thr Ser 85 90 95 Ser Thr Glu Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 45 <211> 2109 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 45 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag tgtctggaat cgacctcagt gtcatcaata tgggctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggaacc attacttatg ttggtaacac atattacgcg 180 agctgggcga aaggcagatt caccatctcc aaaacctcga ccacggtgga tcttaaaatc 240 accagtccga caaccgagga cacggctgtg tattactgtg cgagagaatc tggtactatt 300 tattacagtt actttaactt gtggggccaa gggaccctgg tcaccgtctc gagcgctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc ccaggtgcaa 1380 ttggtggagt ctgggggagg cgtggtccag cctgggaggt ccctgagact ctcctgtgca 1440 gcctctggat tcaccttcag tagctatact atgcactggg tccgccaggc tccaggcaag 1500 gggctggagt gggtgacatt tatatcatat gatggaaaca ataaatacta cgcagactcc 1560 gtgaagggcc gattcaccat ctccagagac aattccaaga acacgctgta tctgcaaatg 1620 aacagcctga gagctgagga cacggctata tattactgtg cgaggaccgg ctggctgggg 1680 ccctttgact actggggcca gggaaccctg gtcaccgtct cgagcggtgg aggcggatct 1740 ggcggaggtg gttccggcgg tggcggctcc ggtggaggcg gttctgaaat tgtgttgacg 1800 cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc 1860 agtcagagtg ttggcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc 1920 aggctcctca tctatggtgc attcagcagg gccactggca tcccagacag gttcagtggc 1980 agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca 2040 gtgtattact gtcagcagta tggtagctca ccgtggacgt tcggccaagg gaccaaggtg 2100 gaaatcaaa 2109 <210> 46 <211> 703 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 46 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser Val Ile 20 25 30 Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Thr Ile Thr Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 85 90 95 Ser Gly Thr Ile Tyr Tyr Ser Tyr Phe Asn Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly 500 505 510 Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 515 520 525 Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly 545 550 555 560 Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 580 585 590 Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 595 600 605 Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 610 615 620 Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 625 630 635 640 Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp 645 650 655 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 660 665 670 Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 675 680 685 Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 47 <211> 648 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 47 gcattcgaat tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaagtgcc aggccagtga aagcattagc aactacttat cctggtatca gcagattcca 120 gggaaagttc ctaagctcct gatctattat gcatccaatc tggcatctgg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaagc tattatggtg gtggtagtgc ctatactttc 300 ggcggaggga ccaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc 360 ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 420 ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 480 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 540 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 600 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt 648 <210> 48 <211> 216 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 48 Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Ile Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly Gly Gly Ser 85 90 95 Ala Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 100 105 110 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 115 120 125 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 130 135 140 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 145 150 155 160 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 165 170 175 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 180 185 190 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 195 200 205 Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 49 <211> 2109 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 49 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cgacttcagt agcggctact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gttgatcgca tgcatttatg ctggtactag tggtagtact 180 tcctacgcga gctgggcgag aggcagattc accatctccg aaacctccaa gaacacggtg 240 actcttcaaa tgaacagcct gagagccgag gactcggctg tgtattactg tgcgagaaat 300 ctttacactt acaatagctt gtggggccag ggaaccctgg tcaccgtctc gagcgctagc 360 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 420 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 480 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 540 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 600 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agagagttga gcccaaatct 660 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg ggcaccgtca 720 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 900 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 960 aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1080 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1140 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200 tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320 agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc ccaggtgcaa 1380 ttggtggagt ctgggggagg cgtggtccag cctgggaggt ccctgagact ctcctgtgca 1440 gcctctggat tcaccttcag tagctatact atgcactggg tccgccaggc tccaggcaag 1500 gggctggagt gggtgacatt tatatcatat gatggaaaca ataaatacta cgcagactcc 1560 gtgaagggcc gattcaccat ctccagagac aattccaaga acacgctgta tctgcaaatg 1620 aacagcctga gagctgagga cacggctata tattactgtg cgaggaccgg ctggctgggg 1680 ccctttgact actggggcca gggaaccctg gtcaccgtct cgagcggtgg aggcggatct 1740 ggcggaggtg gttccggcgg tggcggctcc ggtggaggcg gttctgaaat tgtgttgacg 1800 cagtctccag gcaccctgtc tttgtctcca ggggaaagag ccaccctctc ctgcagggcc 1860 agtcagagtg ttggcagcag ctacttagcc tggtaccagc agaaacctgg ccaggctccc 1920 aggctcctca tctatggtgc attcagcagg gccactggca tcccagacag gttcagtggc 1980 agtgggtctg ggacagactt cactctcacc atcagcagac tggagcctga agattttgca 2040 gtgtattact gtcagcagta tggtagctca ccgtggacgt tcggccaagg gaccaaggtg 2100 gaaatcaaa 2109 <210> 50 <211> 703 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 50 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Gly 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Thr Ser Gly Ser Thr Ser Tyr Ala Ser 50 55 60 Trp Ala Arg Gly Arg Phe Thr Ile Ser Glu Thr Ser Lys Asn Thr Val 65 70 75 80 Thr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asn Leu Tyr Thr Tyr Asn Ser Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 115 120 125 Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 130 135 140 Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 145 150 155 160 Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 165 170 175 Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 180 185 190 Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 195 200 205 Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 210 215 220 His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser 225 230 235 240 Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 245 250 255 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 260 265 270 Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 275 280 285 Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 290 295 300 Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 305 310 315 320 Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 325 330 335 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 340 345 350 Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 355 360 365 Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 370 375 380 Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 385 390 395 400 Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 405 410 415 Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 420 425 430 Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly 435 440 445 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 450 455 460 Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala 465 470 475 480 Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln 485 490 495 Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly 500 505 510 Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 515 520 525 Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 530 535 540 Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly 545 550 555 560 Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 580 585 590 Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu 595 600 605 Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val 610 615 620 Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 625 630 635 640 Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp 645 650 655 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 660 665 670 Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly 675 680 685 Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 700 <210> 51 <211> 657 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 51 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca gagtgtttat gataacaact ggttagcctg gtatcagcag 120 aaaccaggga aagcccctaa gctcctgatc tatacagtat ccactctggc atctggggtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcaccat cagcagcctg 240 cagcctgatg attttgcaac ttattactgc caaggcactt attatagtag tggttggaac 300 tttgctttcg gcggagggac caaggtggag atcaaacgta cggtggctgc accatctgtc 360 ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 420 ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 480 tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 540 agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600 gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt 657 <210> 52 <211> 219 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 52 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 20 25 30 Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Thr Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser 85 90 95 Ser Gly Trp Asn Phe Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 115 120 125 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 130 135 140 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 145 150 155 160 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 165 170 175 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 180 185 190 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 195 200 205 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 53 <211> 2094 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 53 caggagcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctcctttagc agctactgga tgtgctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggatgc attacgactg gtagtggtag cacttactac 180 gcgagctggg cgaagcgccg gttcaccatc tccaaagaca attccaagaa cacggtgact 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtac gagagcattt 300 gacttgtggg gccagggaac cctggtcacc gtctcgagcg ctagcaccaa gggcccatcg 360 gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc 420 ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc 480 agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc 540 gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac 600 aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac 660 acatgcccac cgtgcccagc acctgaagcc gcgggggcac cgtcagtctt cctcttcccc 720 ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 780 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 840 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 900 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc 960 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 1020 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1080 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1140 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1200 ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1260 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1320 ccgggtggcg gtggagggtc cggcggtggt ggatcccagg tgcaattggt ggagtctggg 1380 ggaggcgtgg tccagcctgg gaggtccctg agactctcct gtgcagcctc tggattcacc 1440 ttcagtagct atactatgca ctgggtccgc caggctccag gcaaggggct ggagtgggtg 1500 acatttatat catatgatgg aaacaataaa tactacgcag actccgtgaa gggccgattc 1560 accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagct 1620 gaggacacgg ctatatatta ctgtgcgagg accggctggc tggggccctt tgactactgg 1680 ggccagggaa ccctggtcac cgtctcgagc ggtggaggcg gatctggcgg aggtggttcc 1740 ggcggtggcg gctccggtgg aggcggttct gaaattgtgt tgacgcagtc tccaggcacc 1800 ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttggc 1860 agcagctact tagcctggta ccagcagaaa cctggccagg ctcccaggct cctcatctat 1920 ggtgcattca gcagggccac tggcatccca gacaggttca gtggcagtgg gtctgggaca 1980 gacttcactc tcaccatcag cagactggag cctgaagatt ttgcagtgta ttactgtcag 2040 cagtatggta gctcaccgtg gacgttcggc caagggacca aggtggaaat caaa 2094 <210> 54 <211> 698 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 54 Gln Glu Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Thr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Arg Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Thr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ala Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 435 440 445 Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 450 455 460 Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 465 470 475 480 Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 485 490 495 Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr 500 505 510 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 515 520 525 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 530 535 540 Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp 545 550 555 560 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 580 585 590 Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 595 600 605 Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu 610 615 620 Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 625 630 635 640 Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 660 665 670 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr 675 680 685 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 <210> 55 <211> 651 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 55 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcatttac agctacttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcatccaatc tggcatctgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaaagc agttggttga gtggtgctgt tggtaatgct 300 ttcggcggag ggaccaaggt ggagatcaaa cgtacggtgg ctgcaccatc tgtcttcatc 360 ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg cctgctgaat 420 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 480 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 540 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 <210> 56 <211> 217 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 56 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Trp Leu Ser Gly Ala 85 90 95 Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 57 <211> 2094 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 57 caggagcagg tgaaggagac cgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccatcagc agctatggag tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtcgcattg atttttcccg ggattggttt caaagactac 180 gcgagctggg tgaatggccg gttcaccctc tccagcgaca acgcccagaa cactgtggaa 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagatttg 300 gacttgtggg gccagggaac cctggtcacc gtctcgagcg ctagcaccaa gggcccatcg 360 gtcttccccc tggcaccctc ctccaagagc acctctgggg gcacagcggc cctgggctgc 420 ctggtcaagg actacttccc cgaaccggtg acggtgtcgt ggaactcagg cgccctgacc 480 agcggcgtgc acaccttccc ggctgtccta cagtcctcag gactctactc cctcagcagc 540 gtggtgaccg tgccctccag cagcttgggc acccagacct acatctgcaa cgtgaatcac 600 aagcccagca acaccaaggt ggacaagaga gttgagccca aatcttgtga caaaactcac 660 acatgcccac cgtgcccagc acctgaagcc gcgggggcac cgtcagtctt cctcttcccc 720 ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg 780 gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg 840 cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc 900 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg cgcggtctcc 960 aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga 1020 gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc 1080 ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat 1140 gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1200 ttcctctata gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca 1260 tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct 1320 ccgggtggcg gtggagggtc cggcggtggt ggatcccagg tgcaattggt ggagtctggg 1380 ggaggcgtgg tccagcctgg gaggtccctg agactctcct gtgcagcctc tggattcacc 1440 ttcagtagct atactatgca ctgggtccgc caggctccag gcaaggggct ggagtgggtg 1500 acatttatat catatgatgg aaacaataaa tactacgcag actccgtgaa gggccgattc 1560 accatctcca gagacaattc caagaacacg ctgtatctgc aaatgaacag cctgagagct 1620 gaggacacgg ctatatatta ctgtgcgagg accggctggc tggggccctt tgactactgg 1680 ggccagggaa ccctggtcac cgtctcgagc ggtggaggcg gatctggcgg aggtggttcc 1740 ggcggtggcg gctccggtgg aggcggttct gaaattgtgt tgacgcagtc tccaggcacc 1800 ctgtctttgt ctccagggga aagagccacc ctctcctgca gggccagtca gagtgttggc 1860 agcagctact tagcctggta ccagcagaaa cctggccagg ctcccaggct cctcatctat 1920 ggtgcattca gcagggccac tggcatccca gacaggttca gtggcagtgg gtctgggaca 1980 gacttcactc tcaccatcag cagactggag cctgaagatt ttgcagtgta ttactgtcag 2040 cagtatggta gctcaccgtg gacgttcggc caagggacca aggtggaaat caaa 2094 <210> 58 <211> 698 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 58 Gln Glu Gln Val Lys Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Phe Pro Gly Ile Gly Phe Lys Asp Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Leu Ser Ser Asp Asn Ala Gln Asn Thr Val Glu 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 340 345 350 Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly 435 440 445 Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 450 455 460 Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 465 470 475 480 Phe Ser Ser Tyr Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 485 490 495 Leu Glu Trp Val Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr 500 505 510 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 515 520 525 Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 530 535 540 Ile Tyr Tyr Cys Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp 545 550 555 560 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 565 570 575 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile 580 585 590 Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg 595 600 605 Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu 610 615 620 Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 625 630 635 640 Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser 645 650 655 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 660 665 670 Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr 675 680 685 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 690 695 <210> 59 <211> 648 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 59 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtcc gagtgtttat agtaactact tatcctggta tcagcagaaa 120 ccagggaaag ttcctaagct cctgatctat tatgcatcca ctctggcatc tggggtccca 180 tctcggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag 240 cctgaagatg ttgcaactta ttactgtgca ggcggttata gtagtagtac tcgtgctttc 300 ggcggaggga ccaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc 360 ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 420 ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 480 tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 540 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 600 cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgt 648 <210> 60 <211> 216 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 60 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Tyr Ser Asn 20 25 30 Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 35 40 45 Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Ser 85 90 95 Thr Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 100 105 110 Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 115 120 125 Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 130 135 140 Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 145 150 155 160 Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 165 170 175 Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 180 185 190 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 195 200 205 Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 61 <211> 2121 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 61 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agcagccact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcatttata ctggtagtat tgatgtcttt 180 tactacgcga gctgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 gccgctaata ctgatactac ctactttaac ttgtggggcc agggaaccct ggtcaccgtc 360 tcgagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420 tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480 gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540 tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600 cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt 660 gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 720 ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960 ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080 gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200 cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 1260 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320 tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 1380 tcccaggtgc aattggtgga gtctggggga ggcgtggtcc agcctgggag gtccctgaga 1440 ctctcctgtg cagcctctgg attcaccttc agtagctata ctatgcactg ggtccgccag 1500 gctccaggca aggggctgga gtgggtgaca tttatatcat atgatggaaa caataaatac 1560 tacgcagact ccgtgaaggg ccgattcacc atctccagag acaattccaa gaacacgctg 1620 tatctgcaaa tgaacagcct gagagctgag gacacggcta tatattactg tgcgaggacc 1680 ggctggctgg ggccctttga ctactggggc cagggaaccc tggtcaccgt ctcgagcggt 1740 ggaggcggat ctggcggagg tggttccggc ggtggcggct ccggtggagg cggttctgaa 1800 attgtgttga cgcagtctcc aggcaccctg tctttgtctc caggggaaag agccaccctc 1860 tcctgcaggg ccagtcagag tgttggcagc agctacttag cctggtacca gcagaaacct 1920 ggccaggctc ccaggctcct catctatggt gcattcagca gggccactgg catcccagac 1980 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 2040 gaagattttg cagtgtatta ctgtcagcag tatggtagct caccgtggac gttcggccaa 2100 gggaccaagg tggaaatcaa a 2121 <210> 62 <211> 707 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 62 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 His Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Thr Gly Ser Ile Asp Val Phe Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ala Ala Asn Thr Asp Thr Thr Tyr Phe Asn Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 225 230 235 240 Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 450 455 460 Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg 465 470 475 480 Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met His 485 490 495 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Thr Phe Ile 500 505 510 Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg 515 520 525 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 530 535 540 Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Thr 545 550 555 560 Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 565 570 575 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 580 585 590 Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Gly 595 600 605 Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 610 615 620 Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 625 630 635 640 Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser Arg Ala Thr 645 650 655 Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 660 665 670 Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 675 680 685 Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val 690 695 700 Glu Ile Lys 705 <210> 63 <211> 654 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 63 gcctatgata tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aggccagtca gagcattaac aaccaactat cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatggt gcatccactc tggcatctgg ggtcccatct 180 cggttcaccg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcatgtt cattattgca gtggtggtag ttgtttttgg 300 gctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 360 atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 420 aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 480 ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 540 agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 600 acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt 654 <210> 64 <211> 218 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 64 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asn Asn Gln 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys His Val His Tyr Cys Ser Gly Gly 85 90 95 Ser Cys Phe Trp Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 <210> 65 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 65 atgaaacacc tgtggttctt cctcctcctg gtggcagctc ccagatgggt cctgtcc 57 <210> 66 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 66 Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 1 5 10 15 Val Leu Ser <210> 67 <211> 57 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 67 atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt cctatcc 57 <210> 68 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 68 Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys 1 5 10 15 Val Leu Ser <210> 69 <211> 60 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 69 atgagggccc ctgctcagtt tcttggcttc ttgcttttct ggattccagc ctccagaagt 60 <210> 70 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 70 Met Arg Ala Pro Ala Gln Phe Leu Gly Phe Leu Leu Phe Trp Ile Pro 1 5 10 15 Ala Ser Arg Ser 20 <210> 71 <211> 738 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 71 caggtgcaat tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc gagcggtgga 360 ggcggatctg gcggaggtgg ttccggcggt ggcggctccg gtggaggcgg ttctgaaatt 420 gtgttgacgc agtctccagg caccctgtct ttgtctccag gggaaagagc caccctctcc 480 tgcagggcca gtcagagtgt tggcagcagc tacttagcct ggtaccagca gaaacctggc 540 caggctccca ggctcctcat ctatggtgca ttcagcaggg ccactggcat cccagacagg 600 ttcagtggca gtgggtctgg gacagacttc actctcacca tcagcagact ggagcctgaa 660 gattttgcag tgtattactg tcagcagtat ggtagctcac cgtggacgtt cggccaaggg 720 accaaggtgg aaatcaaa 738 <210> 72 <211> 246 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 72 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln 130 135 140 Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 145 150 155 160 Cys Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala Trp Tyr Gln 165 170 175 Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Phe Ser 180 185 190 Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 195 200 205 Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 210 215 220 Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Trp Thr Phe Gly Gln Gly 225 230 235 240 Thr Lys Val Glu Ile Lys 245 <210> 73 <211> 732 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 73 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgccaggct 120 ccagggaagg ggctggagta catcggctac attggtgata ctactggcat agcctacgcg 180 agctgggcga atggcagatt caccatctcc aaagacaata ccaagaacac ggtggatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggctggtcc 300 tacttagaca tctggggcca agggaccctg gtcaccgtct cgagcggtgg aggcggatct 360 ggcggaggtg gttccggcgg tggcggctcc ggtggaggcg gctctgccct tgtgatgacc 420 cagtctccat cctccctgtc tgcatctgta ggagacagag tcaccatcac ttgccaggcc 480 agtcagaaca tttacagcaa tttagcctgg tatcagcaga aaccagggaa agttcctaag 540 ctcctgatct atcaggcctc cactctggca tctggggtcc catctcggtt cagtggcagt 600 ggatatggga cagatttcac tctcaccatc agcagcctgc agcctgaaga tgttgcaact 660 tattactgtc aaggcggtta ttatagtgct gcccttaata ctttcggcgg agggaccaag 720 gtggagatca aa 732 <210> 74 <211> 244 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 74 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Tyr Ile Gly Asp Thr Thr Gly Ile Ala Tyr Ala Ser Trp Ala Asn 50 55 60 Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Trp Ser Tyr Leu Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Leu Val Met Thr Gln Ser Pro Ser 130 135 140 Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala 145 150 155 160 Ser Gln Asn Ile Tyr Ser Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 Lys Val Pro Lys Leu Leu Ile Tyr Gln Ala Ser Thr Leu Ala Ser Gly 180 185 190 Val Pro Ser Arg Phe Ser Gly Ser Gly Tyr Gly Thr Asp Phe Thr Leu 195 200 205 Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln 210 215 220 Gly Gly Tyr Tyr Ser Ala Ala Leu Asn Thr Phe Gly Gly Gly Thr Lys 225 230 235 240 Val Glu Ile Lys <210> 75 <211> 750 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 75 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cgacttcagt agcggctact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gttgatcgca tgcatttatg ctggtactag tggtagtact 180 tcctacgcga gctgggcgag aggcagattc accatctccg aaacctccaa gaacacggtg 240 actcttcaaa tgaacagcct gagagccgag gactcggctg tgtattactg tgcgagaaat 300 ctttacactt acaatagctt gtggggccag ggaaccctgg tcaccgtctc gagcggtgga 360 ggcggatctg gcggaggtgg ttccggcggt ggcggctccg gtggaggcgg ctctgacatc 420 cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact 480 tgccagtcca gtcagagtgt ttatgataac aactggttag cctggtatca gcagaaacca 540 gggaaagccc ctaagctcct gatctataca gtatccactc tggcatctgg ggtcccatca 600 aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 660 gatgattttg caacttatta ctgccaaggc acttattata gtagtggttg gaactttgct 720 ttcggcggag ggaccaaggt ggagatcaaa 750 <210> 76 <211> 250 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 76 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Gly 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Thr Ser Gly Ser Thr Ser Tyr Ala Ser 50 55 60 Trp Ala Arg Gly Arg Phe Thr Ile Ser Glu Thr Ser Lys Asn Thr Val 65 70 75 80 Thr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asn Leu Tyr Thr Tyr Asn Ser Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 130 135 140 Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 145 150 155 160 Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala Trp Tyr 165 170 175 Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Thr Val Ser 180 185 190 Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 195 200 205 Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 210 215 220 Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser Ser Gly Trp Asn Phe Ala 225 230 235 240 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 245 250 <210> 77 <211> 729 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 77 caggagcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctcctttagc agctactgga tgtgctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggatgc attacgactg gtagtggtag cacttactac 180 gcgagctggg cgaagcgccg gttcaccatc tccaaagaca attccaagaa cacggtgact 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtac gagagcattt 300 gacttgtggg gccagggaac cctggtcacc gtctcgagcg gtggaggcgg atctggcgga 360 ggtggttccg gcggtggcgg ctccggtgga ggcggctctg acatccagat gacccagtct 420 ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcca ggccagtcag 480 agcatttaca gctacttaaa ctggtatcag cagaaaccag ggaaagcccc taagctcctg 540 atctatggtg catccaatct ggcatctggg gtcccatcaa ggttcagtgg cagtggatct 600 gggacagatt tcactctcac catcagcagt ctgcaacctg aagattttgc aacttactac 660 tgtcaaagca gttggttgag tggtgctgtt ggtaatgctt tcggcggagg gaccaaggtg 720 gagatcaaa 729 <210> 78 <211> 243 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 78 Gln Glu Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Thr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Arg Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Thr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ala Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 130 135 140 Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 145 150 155 160 Ser Ile Tyr Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala 165 170 175 Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro 180 185 190 Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 195 200 205 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser 210 215 220 Trp Leu Ser Gly Ala Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val 225 230 235 240 Glu Ile Lys <210> 79 <211> 759 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 79 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agcagccact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcatttata ctggtagtat tgatgtcttt 180 tactacgcga gctgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 gccgctaata ctgatactac ctactttaac ttgtggggcc agggaaccct ggtcaccgtc 360 tcgagcggtg gaggcggatc tggcggaggt ggttccggcg gtggcggctc cggtggaggc 420 ggctctgcct atgatatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga 480 gtcaccatca attgccaggc cagtcagagc attaacaacc aactatcctg gtatcagcag 540 aaaccaggga aagttcctaa gctcctgatc tatggtgcat ccactctggc atctggggtc 600 ccatctcggt tcaccggcag tggatctggg acagatttca ctctcaccat cagcagcctg 660 cagcctgaag atgttgcaac ttattactgt catgttcatt attgcagtgg tggtagttgt 720 ttttgggctt tcggcggagg gaccaaggtg gagatcaaa 759 <210> 80 <211> 253 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 80 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 His Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Thr Gly Ser Ile Asp Val Phe Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ala Ala Asn Thr Asp Thr Thr Tyr Phe Asn Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr 130 135 140 Asp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 145 150 155 160 Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asn Asn Gln Leu Ser 165 170 175 Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Gly 180 185 190 Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Thr Gly Ser Gly 195 200 205 Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 210 215 220 Val Ala Thr Tyr Tyr Cys His Val His Tyr Cys Ser Gly Gly Ser Cys 225 230 235 240 Phe Trp Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 245 250 <210> 81 <211> 735 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 81 cagtcggtgg aggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc 60 tgtaccgcct ctggaatcga ccttaatacc tacgacatga tctgggtccg ccaggctcca 120 ggcaaggggc tagagtgggt tggaatcatt acttatagtg gtagtagata ctacgcgaac 180 tgggcgaaag gccgattcac catctccaaa gacaatacca agaacacggt gtatctgcaa 240 atgaacagcc tgagagctga ggacacggct gtgtattact gtgcgagaga ttatatgagt 300 ggttcccact tgtggggcca gggaaccctg gtcaccgtct cttccggtgg aggcggttca 360 ggcggaggtg gaagtggtgg tggcggctct ggaggcggcg gatctgccta tgatatgacc 420 cagtctccat cttccgtgtc tgcatctgta ggagacagag tcaccatcaa gtgtcaggcc 480 agtgaggaca tttatagctt cttggcctgg tatcagcaga aaccagggaa agcccctaag 540 ctcctgatcc attctgcatc ctctctggca tctggggtcc catcaaggtt cagcggcagt 600 ggatctggga cagatttcac tctcaccatc agcagcctgc agcctgaaga ttttgcaact 660 tactattgtc aacagggtta tggtaaaaat aatgttgata atgctttcgg cggagggacc 720 aaggtggaga tcaaa 735 <210> 82 <211> 245 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 82 Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Asp Leu Asn Thr Tyr Asp 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 35 40 45 Ile Ile Thr Tyr Ser Gly Ser Arg Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Asp Tyr Met Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 115 120 125 Gly Ser Gly Gly Gly Gly Ser Ala Tyr Asp Met Thr Gln Ser Pro Ser 130 135 140 Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Lys Cys Gln Ala 145 150 155 160 Ser Glu Asp Ile Tyr Ser Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly 165 170 175 Lys Ala Pro Lys Leu Leu Ile His Ser Ala Ser Ser Leu Ala Ser Gly 180 185 190 Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 195 200 205 Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 210 215 220 Gln Gly Tyr Gly Lys Asn Asn Val Asp Asn Ala Phe Gly Gly Gly Thr 225 230 235 240 Lys Val Glu Ile Lys 245 <210> 83 <211> 528 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 83 aaagacaata cctcgaccac ggtggatctg caaatgaaca gcctgagagc tgaggacacg 60 gctgtgtatt actgtgcgag agattttatt agtggttccc acttgtgggg ccagggaacc 120 ctggtcaccg tctcgagcgg tggaggcgga tctggcggag gtggttccgg cggtggcggc 180 tccggtggag gcggttctgc ctatgatatg acccagtctc catcttccgt gtctgcatct 240 gtaggagaca gagtcaccat caattgtcag gccagtgaga gcattagtag cttcttatcc 300 tggtatcagc agaaaccagg gaaagcccct aagctcctga tcttttctgc atccactctg 360 gcatctgggg tcccatcaag gttcagcggc agtggatctg ggacagattt cactctcacc 420 atcagcagcc tgcagcctga agattttgca acttactatt gtcaacaggg ttatagtaaa 480 agtaatgtgg ataatgcttt cggcggaggg accaaggtgg agatcaaa 528 <210> 84 <211> 246 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 84 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ile Asp Leu Ser Thr Tyr 20 25 30 Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Ser Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Leu Ser Lys Asp Asn Thr Ser Thr Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Phe Ile Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 115 120 125 Gly Gly Ser Gly Gly Gly Gly Ser Ala Tyr Asp Met Thr Gln Ser Pro 130 135 140 Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln 145 150 155 160 Ala Ser Glu Ser Ile Ser Ser Phe Leu Ser Trp Tyr Gln Gln Lys Pro 165 170 175 Gly Lys Ala Pro Lys Leu Leu Ile Phe Ser Ala Ser Thr Leu Ala Ser 180 185 190 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 195 200 205 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 210 215 220 Gln Gln Gly Tyr Ser Lys Ser Asn Val Asp Asn Ala Phe Gly Gly Gly 225 230 235 240 Thr Lys Val Glu Ile Lys 245 <210> 85 <211> 756 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 85 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt agcgggtacg acatgtgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcattgctg ctggtagtgc tggtatcact 180 tacgacgcga actgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 tcggcgtttt cgttcgacta cgccatggac ctctggggcc agggaaccct ggtcaccgtc 360 tcgagcggtg gaggcggatc tggcggaggt ggttccggcg gtggcggctc cggtggaggc 420 ggctctgaca tccagatgac ccagtctcct tccaccctgt ctgcatctgt aggagacaga 480 gtcaccatca cttgccaggc cagtcagagc attagttccc acttaaactg gtatcagcag 540 aaaccaggga aagcccctaa gctcctgatc tataaggcat ccactctggc atctggggtc 600 ccatcaaggt tcagcggcag tggatctggg acagaattta ctctcaccat cagcagcctg 660 cagcctgatg attttgcaac ttattactgc caacagggtt atagttgggg taatgttgat 720 aatgttttcg gcggagggac caaggtggag atcaaa 756 <210> 86 <211> 252 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 86 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 115 120 125 Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 130 135 140 Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg 145 150 155 160 Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn 165 170 175 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys 180 185 190 Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 195 200 205 Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp 210 215 220 Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp 225 230 235 240 Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 245 250 <210> 87 <211> 750 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 87 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccctcagt agctactgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggagtc attgatacta atgtttatat atactacgcg 180 aactgggcaa aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag atatgtgggt 300 aataatgatg attatattaa cttgtggggc cagggaaccc tggtcaccgt ctcgagcggt 360 ggaggcggat ctggcggagg tggttccggc ggtggcggct ccggtggagg cggctctgac 420 atccagatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 480 acttgccagt ccagtcagag tgtttataat ggctactggt tatcctggta tcagcagaaa 540 ccagggaaag cccctaagct cctgatctat ggtgcatcca ctctggcatc tggggtccca 600 tcaaggttca gcggcagtgg atctgggaca gaattcactc tcaccatcag cagcctgcag 660 cctgatgatt ttgcaactta ttactgccta ggcagttata ctagtagtac tgagaactct 720 ttcggcggag ggaccaaggt ggagatcaaa 750 <210> 88 <211> 250 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 88 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Asp Thr Asn Val Tyr Ile Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Tyr Val Gly Asn Asn Asp Asp Tyr Ile Asn Leu Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 115 120 125 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr 130 135 140 Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 145 150 155 160 Thr Cys Gln Ser Ser Gln Ser Val Tyr Asn Gly Tyr Trp Leu Ser Trp 165 170 175 Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala 180 185 190 Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser 195 200 205 Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe 210 215 220 Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Thr Ser Ser Thr Glu Asn Ser 225 230 235 240 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 245 250 <210> 89 <211> 741 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 89 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag tgtctggaat cgacctcagt gtcatcaata tgggctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggaacc attacttatg ttggtaacac atattacgcg 180 agctgggcga aaggcagatt caccatctcc aaaacctcga ccacggtgga tcttaaaatc 240 accagtccga caaccgagga cacggctgtg tattactgtg cgagagaatc tggtactatt 300 tattacagtt actttaactt gtggggccaa gggaccctgg tcaccgtctc gagcggtgga 360 ggcggatctg gcggaggtgg ttccggcggt ggcggctccg gtggaggcgg ctctgcattc 420 gaattgaccc agtctccatc ctccctgtct gcatctgtag gagacagagt caccatcaag 480 tgccaggcca gtgaaagcat tagcaactac ttatcctggt atcagcagat tccagggaaa 540 gttcctaagc tcctgatcta ttatgcatcc aatctggcat ctggggtccc atctcggttc 600 agtggcagtg gatctgggac agatttcact ctcaccatca gcagcctgca gcctgaagat 660 gttgcaactt attactgtca aagctattat ggtggtggta gtgcctatac tttcggcgga 720 gggaccaagg tggagatcaa a 741 <210> 90 <211> 247 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 90 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser Val Ile 20 25 30 Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Thr Ile Thr Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 85 90 95 Ser Gly Thr Ile Tyr Tyr Ser Tyr Phe Asn Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Phe Glu Leu Thr Gln 130 135 140 Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Lys 145 150 155 160 Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr Leu Ser Trp Tyr Gln Gln 165 170 175 Ile Pro Gly Lys Val Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Leu 180 185 190 Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 195 200 205 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr 210 215 220 Tyr Cys Gln Ser Tyr Tyr Gly Gly Gly Ser Ala Tyr Thr Phe Gly Gly 225 230 235 240 Gly Thr Lys Val Glu Ile Lys 245 <210> 91 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 91 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatacta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtgacattt atatcatatg atggaaacaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctatat attactgtgc gaggaccggc 300 tggctggggc cctttgacta ctggggccag ggaaccctgg tcaccgtctc ctca 354 <210> 92 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 92 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 85 90 95 Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 93 <211> 324 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 93 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttggc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcattca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgtg gacgttcggc 300 caagggacca aggtggaaat caaa 324 <210> 94 <211> 108 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 94 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <210> 95 <211> 345 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 95 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctccctcagt agctatgcaa tgagctgggt ccgccaggct 120 ccagggaagg ggctggagta catcggctac attggtgata ctactggcat agcctacgcg 180 agctgggcga atggcagatt caccatctcc aaagacaata ccaagaacac ggtggatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag aggctggtcc 300 tacttagaca tctggggcca agggaccctg gtcaccgtct cgagc 345 <210> 96 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 96 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 35 40 45 Gly Tyr Ile Gly Asp Thr Thr Gly Ile Ala Tyr Ala Ser Trp Ala Asn 50 55 60 Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Trp Ser Tyr Leu Asp Ile Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 97 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 97 gcccttgtga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gaacatttac agcaatttag cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatcag gcctccactc tggcatctgg ggtcccatct 180 cggttcagtg gcagtggata tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaggc ggttattata gtgctgccct taatactttc 300 ggcggaggga ccaaggtgga gatcaaa 327 <210> 98 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 98 Ala Leu Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Tyr Ser Asn 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Gln Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gly Gly Tyr Tyr Ser Ala Ala 85 90 95 Leu Asn Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 99 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 99 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cgacttcagt agcggctact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gttgatcgca tgcatttatg ctggtactag tggtagtact 180 tcctacgcga gctgggcgag aggcagattc accatctccg aaacctccaa gaacacggtg 240 actcttcaaa tgaacagcct gagagccgag gactcggctg tgtattactg tgcgagaaat 300 ctttacactt acaatagctt gtggggccag ggaaccctgg tcaccgtctc gagc 354 <210> 100 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 100 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Ser Gly 20 25 30 Tyr Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu 35 40 45 Ile Ala Cys Ile Tyr Ala Gly Thr Ser Gly Ser Thr Ser Tyr Ala Ser 50 55 60 Trp Ala Arg Gly Arg Phe Thr Ile Ser Glu Thr Ser Lys Asn Thr Val 65 70 75 80 Thr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ser Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Asn Leu Tyr Thr Tyr Asn Ser Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 101 <211> 336 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 101 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca gagtgtttat gataacaact ggttagcctg gtatcagcag 120 aaaccaggga aagcccctaa gctcctgatc tatacagtat ccactctggc atctggggtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcaccat cagcagcctg 240 cagcctgatg attttgcaac ttattactgc caaggcactt attatagtag tggttggaac 300 tttgctttcg gcggagggac caaggtggag atcaaa 336 <210> 102 <211> 112 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 102 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asp Asn 20 25 30 Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Thr Val Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Tyr Ser 85 90 95 Ser Gly Trp Asn Phe Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 103 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 103 caggagcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtacag cctctggatt ctcctttagc agctactgga tgtgctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggatgc attacgactg gtagtggtag cacttactac 180 gcgagctggg cgaagcgccg gttcaccatc tccaaagaca attccaagaa cacggtgact 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtac gagagcattt 300 gacttgtggg gccagggaac cctggtcacc gtctcgagc 339 <210> 104 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 104 Gln Glu Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Ser Ser Tyr 20 25 30 Trp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Cys Ile Thr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala 50 55 60 Lys Arg Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Thr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ala Phe Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 105 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 105 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcatttac agctacttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatggt gcatccaatc tggcatctgg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240 gaagattttg caacttacta ctgtcaaagc agttggttga gtggtgctgt tggtaatgct 300 ttcggcggag ggaccaaggt ggagatcaaa 330 <210> 106 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 106 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Tyr Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Ser Trp Leu Ser Gly Ala 85 90 95 Val Gly Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 107 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 107 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt cacctttagc agcagccact ggatatgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcatttata ctggtagtat tgatgtcttt 180 tactacgcga gctgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 gccgctaata ctgatactac ctactttaac ttgtggggcc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 108 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 108 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 20 25 30 His Trp Ile Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Tyr Thr Gly Ser Ile Asp Val Phe Tyr Tyr Ala Ser 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ala Ala Asn Thr Asp Thr Thr Tyr Phe Asn Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 109 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 109 gcctatgata tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaattgcc aggccagtca gagcattaac aaccaactat cctggtatca gcagaaacca 120 gggaaagttc ctaagctcct gatctatggt gcatccactc tggcatctgg ggtcccatct 180 cggttcaccg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcatgtt cattattgca gtggtggtag ttgtttttgg 300 gctttcggcg gagggaccaa ggtggagatc aaa 333 <210> 110 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 110 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Ile Asn Asn Gln 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Thr Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys His Val His Tyr Cys Ser Gly Gly 85 90 95 Ser Cys Phe Trp Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 111 <211> 345 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 111 cagtcggtgg aggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc 60 tgtaccgcct ctggaatcga ccttaatacc tacgacatga tctgggtccg ccaggctcca 120 ggcaaggggc tagagtgggt tggaatcatt acttatagtg gtagtagata ctacgcgaac 180 tgggcgaaag gccgattcac catctccaaa gacaatacca agaacacggt gtatctgcaa 240 atgaacagcc tgagagctga ggacacggct gtgtattact gtgcgagaga ttatatgagt 300 ggttcccact tgtggggcca gggaaccctg gtcaccgtct cttcc 345 <210> 112 <211> 115 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 112 Gln Ser Val Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 1 5 10 15 Leu Arg Leu Ser Cys Thr Ala Ser Gly Ile Asp Leu Asn Thr Tyr Asp 20 25 30 Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly 35 40 45 Ile Ile Thr Tyr Ser Gly Ser Arg Tyr Tyr Ala Asn Trp Ala Lys Gly 50 55 60 Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Thr Val Tyr Leu Gln 65 70 75 80 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 85 90 95 Asp Tyr Met Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <210> 113 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 113 gcctatgata tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcaagtgtc aggccagtga ggacatttat agcttcttgg cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatccattct gcatcctctc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag ggttatggta aaaataatgt tgataatgct 300 ttcggcggag ggaccaaggt ggagatcaaa 330 <210> 114 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 114 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Asp Ile Tyr Ser Phe 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 His Ser Ala Ser Ser Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Gly Lys Asn Asn 85 90 95 Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 115 <211> 348 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 115 caggtgcagc tggtggagtc tgggggaggc ctggtccagc ctgggggctc cctgagactc 60 tcctgtacaa cttctggaat cgaccttagt acctacgaca tgatctgggt ccgccaggct 120 ccaggcaagg ggctagagtg ggtgggaatc attagttatg ttggtaacac atactacgcg 180 agctgggcga aaggccgatt caccctctcc aaagacaata cctcgaccac ggtggatctg 240 caaatgaaca gcctgagagc tgaggacacg gctgtgtatt actgtgcgag agattttatt 300 agtggttccc acttgtgggg ccagggaacc ctggtcaccg tctcgagc 348 <210> 116 <211> 116 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 116 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Thr Ser Gly Ile Asp Leu Ser Thr Tyr 20 25 30 Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ile Ile Ser Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Leu Ser Lys Asp Asn Thr Ser Thr Thr Val Asp Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Phe Ile Ser Gly Ser His Leu Trp Gly Gln Gly Thr Leu Val 100 105 110 Thr Val Ser Ser 115 <210> 117 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 117 gcctatgata tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60 atcaattgtc aggccagtga gagcattagt agcttcttat cctggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatcttttct gcatccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagattttg caacttacta ttgtcaacag ggttatagta aaagtaatgt ggataatgct 300 ttcggcggag ggaccaaggt ggagatcaaa 330 <210> 118 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 118 Ala Tyr Asp Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Phe 20 25 30 Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Phe Ser Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Lys Ser Asn 85 90 95 Val Asp Asn Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 119 <211> 366 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 119 gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccttcagt agcgggtacg acatgtgctg ggtccgccag 120 gctccaggga aggggctgga gtggatcgca tgcattgctg ctggtagtgc tggtatcact 180 tacgacgcga actgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240 ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300 tcggcgtttt cgttcgacta cgccatggac ctctggggcc agggaaccct ggtcaccgtc 360 tcgagc 366 <210> 120 <211> 122 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 120 Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly 20 25 30 Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 35 40 45 Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn 50 55 60 Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 <210> 121 <211> 330 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 121 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240 gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 300 ttcggcggag ggaccaaggt ggagatcaaa 330 <210> 122 <211> 110 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 122 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn 85 90 95 Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 123 <211> 357 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 123 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt ctccctcagt agctactgga tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggagtc attgatacta atgtttatat atactacgcg 180 aactgggcaa aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag atatgtgggt 300 aataatgatg attatattaa cttgtggggc cagggaaccc tggtcaccgt ctcgagc 357 <210> 124 <211> 119 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 124 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Ser Tyr 20 25 30 Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Val Ile Asp Thr Asn Val Tyr Ile Tyr Tyr Ala Asn Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Tyr Val Gly Asn Asn Asp Asp Tyr Ile Asn Leu Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 <210> 125 <211> 333 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 125 gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtca gagtgtttat aatggctact ggttatcctg gtatcagcag 120 aaaccaggga aagcccctaa gctcctgatc tatggtgcat ccactctggc atctggggtc 180 ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcaccat cagcagcctg 240 cagcctgatg attttgcaac ttattactgc ctaggcagtt atactagtag tactgagaac 300 tctttcggcg gagggaccaa ggtggagatc aaa 333 <210> 126 <211> 111 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 126 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Asn Gly 20 25 30 Tyr Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 35 40 45 Leu Ile Tyr Gly Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 50 55 60 Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu 65 70 75 80 Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Thr Ser 85 90 95 Ser Thr Glu Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 <210> 127 <211> 354 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 127 gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60 tcctgtacag tgtctggaat cgacctcagt gtcatcaata tgggctgggt ccgccaggct 120 ccagggaagg ggctggagtg gatcggaacc attacttatg ttggtaacac atattacgcg 180 agctgggcga aaggcagatt caccatctcc aaaacctcga ccacggtgga tcttaaaatc 240 accagtccga caaccgagga cacggctgtg tattactgtg cgagagaatc tggtactatt 300 tattacagtt actttaactt gtggggccaa gggaccctgg tcaccgtctc gagc 354 <210> 128 <211> 118 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 128 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Thr Val Ser Gly Ile Asp Leu Ser Val Ile 20 25 30 Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Thr Ile Thr Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys 50 55 60 Gly Arg Phe Thr Ile Ser Lys Thr Ser Thr Thr Val Asp Leu Lys Ile 65 70 75 80 Thr Ser Pro Thr Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Glu 85 90 95 Ser Gly Thr Ile Tyr Tyr Ser Tyr Phe Asn Leu Trp Gly Gln Gly Thr 100 105 110 Leu Val Thr Val Ser Ser 115 <210> 129 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 129 gcattcgaat tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcaagtgcc aggccagtga aagcattagc aactacttat cctggtatca gcagattcca 120 gggaaagttc ctaagctcct gatctattat gcatccaatc tggcatctgg ggtcccatct 180 cggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatgttg caacttatta ctgtcaaagc tattatggtg gtggtagtgc ctatactttc 300 ggcggaggga ccaaggtgga gatcaaa 327 <210> 130 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 130 Ala Phe Glu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Lys Cys Gln Ala Ser Glu Ser Ile Ser Asn Tyr 20 25 30 Leu Ser Trp Tyr Gln Gln Ile Pro Gly Lys Val Pro Lys Leu Leu Ile 35 40 45 Tyr Tyr Ala Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Gly Gly Gly Ser 85 90 95 Ala Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 131 <211> 339 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 131 caggagcagg tgaaggagac cgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccatcagc agctatggag tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtcgcattg atttttcccg ggattggttt caaagactac 180 gcgagctggg tgaatggccg gttcaccctc tccagcgaca acgcccagaa cactgtggaa 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagatttg 300 gacttgtggg gccagggaac cctggtcacc gtctcgagc 339 <210> 132 <211> 113 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 132 Gln Glu Gln Val Lys Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Phe Pro Gly Ile Gly Phe Lys Asp Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Leu Ser Ser Asp Asn Ala Gln Asn Thr Val Glu 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser <210> 133 <211> 327 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 133 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc agtccagtcc gagtgtttat agtaactact tatcctggta tcagcagaaa 120 ccagggaaag ttcctaagct cctgatctat tatgcatcca ctctggcatc tggggtccca 180 tctcggttca gtggcagtgg atctgggaca gatttcactc tcaccatcag cagcctgcag 240 cctgaagatg ttgcaactta ttactgtgca ggcggttata gtagtagtac tcgtgctttc 300 ggcggaggga ccaaggtgga gatcaaa 327 <210> 134 <211> 109 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 134 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro Ser Val Tyr Ser Asn 20 25 30 Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu 35 40 45 Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser Ser 85 90 95 Thr Arg Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 <210> 135 <211> 987 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 135 gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggt 987 <210> 136 <211> 329 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 136 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 <210> 137 <211> 987 <212> DNA <213> Artificial Sequence <220> <223> synthesized <400> 137 gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60 ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120 tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180 ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240 tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 300 aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgcgggggca 360 ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420 gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480 tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540 agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600 gagtacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660 aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 720 ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780 gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840 ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg 900 cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960 cagaagagcc tctccctgtc tccgggt 987 <210> 138 <211> 329 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 138 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 <210> 139 <211> 726 <212> DNA <213> Artificial Sequence <220> <223> Synthesized <400> 139 caggagcagg tgaaggagac cgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccatcagc agctatggag tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtcgcattg atttttcccg ggattggttt caaagactac 180 gcgagctggg tgaatggccg gttcaccctc tccagcgaca acgcccagaa cactgtggaa 240 ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagagatttg 300 gacttgtggg gccagggaac cctggtcacc gtctcgagcg gtggaggcgg atctggcgga 360 ggtggttccg gcggtggcgg ctccggtgga ggcggctctg acatccagat gacccagtct 420 ccatcctccc tgtctgcatc tgtaggagac agagtcacca tcacttgcca gtccagtccg 480 agtgtttata gtaactactt atcctggtat cagcagaaac cagggaaagt tcctaagctc 540 ctgatctatt atgcatccac tctggcatct ggggtcccat ctcggttcag tggcagtgga 600 tctgggacag atttcactct caccatcagc agcctgcagc ctgaagatgt tgcaacttat 660 tactgtgcag gcggttatag tagtagtact cgtgctttcg gcggagggac caaggtggag 720 atcaaa 726 <210> 140 <211> 242 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 140 Gln Glu Gln Val Lys Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Ser Tyr 20 25 30 Gly Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Leu Ile Phe Pro Gly Ile Gly Phe Lys Asp Tyr Ala Ser Trp Val 50 55 60 Asn Gly Arg Phe Thr Leu Ser Ser Asp Asn Ala Gln Asn Thr Val Glu 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 115 120 125 Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 130 135 140 Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Pro 145 150 155 160 Ser Val Tyr Ser Asn Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys 165 170 175 Val Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Leu Ala Ser Gly Val 180 185 190 Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 195 200 205 Ile Ser Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gly 210 215 220 Gly Tyr Ser Ser Ser Thr Arg Ala Phe Gly Gly Gly Thr Lys Val Glu 225 230 235 240 Ile Lys <210> 141 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 141 Ser Ser Tyr Thr Met His 1 5 <210> 142 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 142 Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <210> 143 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 143 Thr Gly Trp Leu Gly Pro Phe Asp Tyr 1 5 <210> 144 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 144 Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 1 5 10 <210> 145 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 145 Gly Ala Phe Ser Arg Ala Thr 1 5 <210> 146 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 146 Gln Gln Tyr Gly Ser Ser Pro Trp Thr 1 5 <210> 147 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 147 Asn Thr Tyr Asp Met Ile 1 5 <210> 148 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 148 Ile Ile Thr Tyr Ser Gly Ser Arg Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 149 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 149 Asp Tyr Met Ser Gly Ser His Leu 1 5 <210> 150 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 150 Gln Ala Ser Glu Asp Ile Tyr Ser Phe Leu Ala 1 5 10 <210> 151 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 151 Ser Ala Ser Ser Leu Ala Ser 1 5 <210> 152 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 152 Gln Gln Gly Tyr Gly Lys Asn Asn Val Asp Asn Ala 1 5 10 <210> 153 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 153 Asn Thr Tyr Asp Met Ile 1 5 <210> 154 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 154 Ile Ile Thr Tyr Ser Gly Ser Arg Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 155 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 155 Asp Tyr Met Ser Gly Ser His Leu 1 5 <210> 156 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 156 Gln Ala Ser Glu Asp Ile Tyr Ser Phe Leu Ala 1 5 10 <210> 157 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 157 Ser Ala Ser Ser Leu Ala Ser 1 5 <210> 158 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 158 Gln Gln Gly Tyr Gly Lys Asn Asn Val Asp Asn Ala 1 5 10 <210> 159 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 159 Ser Gly Tyr Asp Met Cys 1 5 <210> 160 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 160 Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala 1 5 10 15 Lys Gly <210> 161 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 161 Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu 1 5 10 <210> 162 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 162 Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn 1 5 10 <210> 163 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 163 Lys Ala Ser Thr Leu Ala Ser 1 5 <210> 164 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 164 Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val 1 5 10 <210> 165 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 165 Ser Thr Tyr Asp Met Ile 1 5 <210> 166 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 166 Ile Ile Ser Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 167 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 167 Asp Phe Ile Ser Gly Ser His Leu 1 5 <210> 168 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 168 Gln Ala Ser Glu Ser Ile Ser Ser Phe Leu Ser 1 5 10 <210> 169 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 169 Ser Ala Ser Thr Leu Ala Ser 1 5 <210> 170 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 170 Gln Gln Gly Tyr Ser Lys Ser Asn Val Asp Asn Ala 1 5 10 <210> 171 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 171 Ser Ser Tyr Trp Met Ser 1 5 <210> 172 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 172 Val Ile Asp Thr Asn Val Tyr Ile Tyr Tyr Ala Asn Trp Ala Lys Gly 1 5 10 15 <210> 173 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 173 Tyr Val Gly Asn Asn Asp Asp Tyr Ile Asn Leu 1 5 10 <210> 174 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 174 Gln Ser Ser Gln Ser Val Tyr Asn Gly Trp Leu Ser 1 5 10 <210> 175 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 175 Gly Ala Ser Thr Leu Ala Ser 1 5 <210> 176 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 176 Leu Gly Ser Tyr Thr Ser Ser Thr Glu Asn Ser 1 5 10 <210> 177 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 177 Ser Val Ile Asn Met Gly 1 5 <210> 178 <211> 16 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 178 Thr Ile Thr Tyr Val Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly 1 5 10 15 <210> 179 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 179 Glu Ser Gly Thr Ile Tyr Tyr Ser Tyr Phe Asn Leu 1 5 10 <210> 180 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 180 Gln Ala Ser Glu Ser Ile Ser Asn Tyr Leu Ser 1 5 10 <210> 181 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 181 Tyr Ala Ser Asn Leu Ala Ser 1 5 <210> 182 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 182 Gln Ser Tyr Tyr Gly Gly Gly Ser Ala Tyr Thr 1 5 10 <210> 183 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 183 Ser Gly Tyr Trp Ile Cys 1 5 <210> 184 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 184 Cys Ile Tyr Ala Gly Thr Ser Gly Ser Thr Ser Tyr Ala Ser Trp Ala 1 5 10 15 Arg Gly <210> 185 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 185 Asn Leu Tyr Thr Tyr Asn Ser Leu 1 5 <210> 186 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 186 Gln Ser Ser Gln Ser Val Tyr Asp Asn Asn Trp Leu Ala 1 5 10 <210> 187 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 187 Thr Val Ser Thr Leu Ala Ser 1 5 <210> 188 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 188 Gln Gly Thr Tyr Tyr Ser Ser Gly Trp Asn Phe Ala 1 5 10 <210> 189 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 189 Ser Ser Tyr Trp Met Cys 1 5 <210> 190 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 190 Cys Ile Thr Thr Gly Ser Gly Ser Thr Tyr Tyr Ala Ser Trp Ala Lys 1 5 10 15 Arg <210> 191 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 191 Ala Phe Asp Leu 1 <210> 192 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 192 Gln Ala Ser Gln Ser Ile Tyr Ser Tyr Leu Asn 1 5 10 <210> 193 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 193 Gly Ala Ser Asn Leu Ala Ser 1 5 <210> 194 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 194 Gln Ser Ser Trp Leu Ser Gly Ala Val Gly Asn Ala 1 5 10 <210> 195 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 195 Ser Ser Tyr Gly Val Ser 1 5 <210> 196 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 196 Leu Ile Phe Pro Gly Ile Gly Phe Lys Asp Tyr Ala Ser Trp Val Asn 1 5 10 15 Gly <210> 197 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 197 Asp Leu Asp Leu 1 <210> 198 <211> 12 <212> PRT <213> Artificial Sequence <220> <223> synthesized <400> 198 Gln Ser Ser Pro Ser Val Tyr Ser Asn Tyr Leu Ser 1 5 10 <210> 199 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 199 Tyr Ala Ser Thr Leu Ala Ser 1 5 <210> 200 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 200 Ala Gly Gly Tyr Ser Ser Ser Thr Arg Ala 1 5 10 <210> 201 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 201 Ser Ser His Trp Ile Cys 1 5 <210> 202 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 202 Cys Ile Tyr Thr Gly Ser Ile Asp Val Phe Tyr Tyr Ala Ser Trp Ala 1 5 10 15 Lys Gly <210> 203 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 203 Ala Ala Asn Thr Asp Thr Thr Tyr Phe Asn Leu 1 5 10 <210> 204 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 204 Gln Ala Ser Gln Ser Ile Asn Asn Gln Leu Ser 1 5 10 <210> 205 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 205 Gly Ala Ser Thr Leu Ala Ser 1 5 <210> 206 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthesized <400> 206 His Val His Tyr Cys Ser Gly Gly Ser Cys Phe Trp Ala 1 5 10

Claims (41)

  1. 중쇄 및 경쇄를 포함하는 IgG 도메인; 및 중쇄의 C 말단 또는 경쇄의 N 말단에 연결된 2개의 scFv 성분을 포함하는 이중특이성 항체(bispecific antibody)로서, 여기서 IgG 도메인이 제1 항원에 대한 제1 결합 특이성을 갖고, scFv 성분이 제2 항원에 대한 제2 결합 특이성을 가지며, 상기 제1 항원이 α-CTLA4를 포함하고, 제2 항원이 α-PD-1 또는 α-PD-L1을 포함하며,
    상기 IgG 도메인이 서열번호 141 내지 143의 중쇄 가변 영역의 CDR 1 내지 3, 및 서열번호 144 내지 146의 경쇄 가변 영역의 CDR 1 내지 3을 포함하고;
    상기 scFv 성분이 서열번호 153 내지 155의 중쇄 가변 영역의 CDR 1 내지 3, 및 서열번호 156 내지 158의 경쇄 가변 영역의 CDR 1 내지 3; 또는 서열번호 159 내지 161의 중쇄 가변 영역의 CDR 1 내지 3, 및 서열번호 162 내지 164의 경쇄 가변 영역의 CDR 1 내지 3을 포함하는, 이중특이성 항체.
  2. 제1항에 있어서,
    IgG 도메인이 서열번호 94를 포함하는 가변 경쇄, 및 서열번호 92를 포함하는 가변 중쇄를 포함하고;
    scFv 성분이 서열번호 98을 포함하는 가변 경쇄, 및 서열번호 96을 포함하는 가변 중쇄; 또는 서열번호 122을 포함하는 가변 경쇄, 및 서열번호 120을 포함하는 가변 중쇄를 포함하는, 이중특이성 항체.
  3. 제1항에 있어서, 2개의 scFv 성분이 중쇄의 C 말단에 연결된, 이중특이성 항체.
  4. 제1항에 있어서, 2개의 scFv 성분이 경쇄의 N 말단에 연결된, 이중특이성 항체.
  5. 제1항에 있어서, 이중특이성 항체가 단리된 단일클론(monoclonal) 항체인, 이중특이성 항체.
  6. 제1항에 있어서, α-CTLA4에 대한 제1 결합 특이성, 및 α-PD-1 또는 α-PD-L1에 대한 제2 결합 특이성을 가지며, 상기 제1 및 제2 결합 특이성 모두 70nM 이하의 Kd를 갖는, 이중특이성 항체.
  7. 제1항에 있어서, α-CTLA4에 대한 제1 결합 특이성, 및 α-PD-1에 대한 제2 결합 특이성을 가지며, 상기 제1 및 제2 결합 특이성 모두 70nM 이하의 Kd를 갖는, 이중특이성 항체.
  8. 제1항에 있어서, α-CTLA4에 대한 제1 결합 특이성, 및 α-PD-L1에 대한 제2 결합 특이성을 가지며, 상기 제1 및 제2 결합 특이성 모두 70nM 이하의 Kd를 갖는, 이중특이성 항체.
  9. 제1항에 있어서, 인간 프레임워크(framework) 영역을 포함하는, 이중특이성 항체.
  10. 제1항에 있어서, 항체가 인간화 항체, 키메라 항체(chimeric antibody), 또는 재조합 항체인, 이중특이성 항체.
  11. 제1항에 있어서, IgG 도메인이 IgG1 불변 영역을 포함하고, 상기 IgG1 불변 영역이 서열번호 136와 적어도 98% 유사성(similarity)을 갖는 아미노산 서열을 포함하는, 이중특이성 항체.
  12. 제1항 내지 제11항 중 어느 한 항의 이중특이성 항체를 암호화하는, 단리된 핵산.
  13. 제12항의 단리된 핵산을 포함하는, 발현 벡터.
  14. 제13항에 있어서, 벡터는 세포 내에서 발현가능한 것인, 발현 벡터.
  15. 제12항의 핵산 또는 상기 핵산을 포함하는 발현 벡터를 포함하는 단리된 숙주 세포.
  16. 제15항에 있어서, 숙주 세포가 원핵 세포 또는 진핵 세포인, 숙주 세포.
  17. 제15항의 숙주 세포를 배양하여 이중특이성 항체를 생산하는 단계를 포함하는, 이중특이성 항체를 생산하는 방법.
  18. 제1항 내지 제11항 중 어느 한 항의 이중특이성 항체 및 세포독성제(cytotoxic agent)를 포함하는 면역접합체(immunoconjugate).
  19. 제18항에 있어서, 세포독성제가 화학치료제, 성장 억제제, 독소, 또는 방사성 동위원소인, 면역접합체.
  20. 제1항 내지 제11항 중 어느 한 항의 이중특이성 항체 및 약학적으로 허용되는 담체를 포함하는, 암을 가진 대상체를 치료하기 위한 약학 조성물.
  21. 제20항에 있어서, 방사성동위원소, 방사성핵종, 독소, 치료제, 화학치료제, 또는 이의 조합을 추가로 포함하는, 약학 조성물.
  22. 제18항의 면역접합체 및 약학적으로 허용되는 담체를 포함하는, 암을 가진 대상체를 치료하기 위한 약학 조성물.
  23. 유효량의 제1항 내지 제11항 중 어느 한 항의 이중특이성 항체를 포함하는, 암을 가진 대상체를 치료하기 위한 약학 조성물.
  24. 제23항에 있어서, 암이 PD-L1을 발현하는 세포를 포함하는, 약학 조성물.
  25. 제23항에 있어서, 암이 유방암, 결장직암, 췌장암, 두경부암, 흑색종, 난소암, 전립선암, 비소세포폐암, 소세포폐암, 신경교종, 식도암, 비인두암, 신장암, 위암, 간암, 방광암, 자궁경부암, 뇌암, 림프종, 백혈병, 또는 골수종을 포함하는, 약학 조성물.
  26. 제23항에 있어서, 치료가 유효량의 치료제의 공동 투여를 포함하는, 약학 조성물.
  27. 제26항에 있어서, 치료제가 항체, 화학요법제, 효소, 또는 이의 조합을 포함하는, 약학 조성물.
  28. 제26항에 있어서, 치료제가 카페시타빈(capecitabine), 시스플라틴(cisplatin), 트라스투주맙(trastuzumab), 풀베스트란트(fulvestrant), 타목시펜(tamoxifen), 레트로졸(letrozole), 엑세메스탄(exemestane), 아나스트로졸(anastrozole), 아미노글루테티미드(aminoglutethimide), 테스톨락톤(testolactone), 보로졸(vorozole), 포르메스탄(formestane), 파드로졸(fadrozole), 레트로졸(letrozole), 에를로티닙(erlotinib), 라파티닙(lafatinib), 다사티닙(dasatinib), 게피티닙(gefitinib), 이마티닙(imatinib), 파조피닙(pazopinib), 라파티닙(lapatinib), 수니티닙(sunitinib), 닐로티닙(nilotinib), 소라페닙(sorafenib), 납-팔리탁셀(nab-palitaxel), 또는 이의 조합을 포함하는, 약학 조성물.
  29. 제23항에 있어서, 대상체가 인간인, 약학 조성물.
  30. 삭제
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  32. 삭제
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  41. 삭제
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