KR19990077184A - Disinfection Compositions and Surface Disinfection Methods - Google Patents

Abstract

The present invention relates to disinfecting surfaces with disinfecting compositions comprising from 0.1 to 15% by weight of hydrogen peroxide, and antimicrobial essential oils or mixtures thereof.

Description

Disinfection Compositions and Surface Disinfection Methods

Antimicrobial / antimicrobial compositions include materials that have antiseptic properties. In general, disinfecting materials are known to greatly reduce or even eliminate microorganisms, such as bacteria, present on the surface. Compositions based on halogen-containing compounds or quaternary compounds, such as hypochlorite, are widely described in the art for disinfection purposes. Compositions comprising peracids are also known as disinfecting compositions.

However, a drawback with such disinfecting compositions based on peracids is that they can damage the surfaces that are contacted to perform the disinfecting action. Indeed, such disinfecting compositions based on peracids are recognized by consumers as unsafe for hard surfaces and various surfaces, including delicate fabrics such as silk, wool and the like.

Therefore, it is an object of the present invention to provide a disinfection composition which, even when used in a dilute state with high proportions, does not lower the disinfection ability to the surface and at the same time imparts improved safety to the treated surface.

It has recently been found that the above object can be achieved by providing a composition comprising from 0.1 to 15% by weight of hydrogen peroxide, and an antimicrobial essential oil or mixtures thereof. More specifically, compositions of the present invention comprising hydrogen peroxide and antimicrobial essential oils can be applied to clean surfaces, i.e. surfaces free of inorganic and / or organic contaminants, even when diluted at high ratios of, for example, 1: 100 (composition: water). It has been found to provide good disinfection and at the same time improve the safety of the surface treated thereby.

In addition, the compositions according to the invention are suitable for disinfecting all types of surfaces, including surfaces of living organisms (eg, oral preparations when used as human skin and / or oral preparations or toothpastes) and surfaces of inanimate objects. Indeed, these techniques can be applied to hard surfaces as well as to laundry applications as so-called "soaking", "through the wash mode" laundry detergents or laundry additives, or as "pretreatment" laundry pretreatments, and the like. Is especially suitable. More specifically, the compositions according to the present invention are suitable for safe use on delicate surfaces, including surfaces in contact with food and / or infants. In fact, when the composition according to the invention is used in a diluted state, the amount of chemical residue remaining on the surface sterilized with this composition is reduced. Thus, there will be no need to wash the surface after application of the composition of the invention in a diluted state, for example on a hard surface.

An advantage of the present invention is that excellent disinfection is provided over a broad range of gram-positive strains and pure bacterial strains, including gram-negative strains, and more resistant microorganisms such as fungi.

Another advantage of the compositions of the present invention is that, in particular embodiments of the present invention wherein the compositions further comprise surfactants and / or solvents, good detergency in addition to disinfection is provided.

Another advantage of the compositions of the present invention is that they can be in various forms, such as in liquid form packaged in a conventional detergent container, or in sprayable or foamable form packaged in a spray / foam dispenser, or the composition It can be provided in the form of wipes incorporating or in the form of a non-liquid (eg gel, paste or solid).

A representative example of the prior art is WO88 / 00795, which discloses a liquid disinfection composition comprising a compound selected from the group of organic acids, perborates, peracids and salts thereof with quaternary ammonium salts and essential oils. This document does not disclose the amount of hydrogen peroxide as well as the use of hydrogen peroxide in the disinfection composition.

EP-B-288 689 discloses a hard surface liquid composition comprising an oil extract and at least one fat soluble organic acid in an antimicrobial effective amount. Hydrogen peroxide is not disclosed at all.

US-5,403,587 discloses aqueous antimicrobial compositions that can be used to sanitize, disinfect and clean hard surfaces. More specifically, US-5,403,587 discloses essential oils (0.02-5%) exhibiting antimicrobial efficacy, such as thyme oil, eucalyptus oil and clove oil, and water carriers. An aqueous composition (pH 1-12) is disclosed which comprises a solubilizer or dispersant sufficient to form an aqueous solution or dispersion of the essential oil. Hydrogen peroxide is not disclosed at all.

Summary of the Invention

The present invention includes a disinfecting composition comprising from 0.1 to 15% by weight of hydrogen peroxide, and an antimicrobial essential oil or mixtures thereof.

The invention further comprises a method for disinfecting a surface, applying the disinfection composition according to the invention to a surface.

The present invention provides a surface of living organisms such as human skin and oral cavity; And various surfaces, including, for example, walls, tiles, table tops, glass, bathroom surfaces, kitchen surfaces, hard surfaces such as dishes, and non-living surfaces including, but not limited to, textiles, clothing, carpets, and the like. It relates to an antimicrobial composition that can be used.

Disinfection Compositions:

Disinfectant compositions according to the present invention comprise 0.1 to 15% by weight of hydrogen peroxide, and antimicrobial essential oils of the total composition.

The compositions according to the invention can be formulated in liquid or non-liquid form (eg in the form of gels, pastes or solids such as powders or granules). If the compositions are formulated as solids, they will be mixed with a suitable solvent, typically water, before use. The liquid composition herein may be an aqueous composition or a non-aqueous composition. Liquid compositions are preferred herein for ease of use.

Hydrogen peroxide is included as an essential element of the composition according to the invention.

Hydrogen peroxide present in the composition of the present invention appears to contribute to the disinfectability of the composition. Indeed, the hydrogen peroxide may attack the growth function of the microbial cells, for example, may inhibit the assembly of ribosomal units in the cytoplasm of the microbial cells. Hydrogen peroxide is also a strong oxidant, generating hydroxy free radicals that attack proteins and nucleic acids. In addition, the presence of hydrogen peroxide offers the advantage of strong contaminant removal, particularly noteworthy when applied to laundry and hard surfaces.

The composition herein comprises 0.1 to 15%, preferably 0.5 to 10%, more preferably 1 to 8%, hydrogen peroxide of the total composition.

The composition according to the invention comprises, as the second essential ingredient, an antimicrobial essential oil or mixtures thereof. Typically, the composition comprises at least 0.003%, preferably 0.006 to 10%, more preferably 0.2 to 4%, most preferably 0.2 to 2% by weight of antimicrobial essential oils of the total composition.

Antimicrobial essential oils suitable for use in the compositions include any essential oil that exhibits antimicrobial activity. The antimicrobial essential oils are believed to act as protein denaturants. In addition, antimicrobial essential oils contribute to the safety profile of the compositions of the present invention when used to disinfect any surface. A further advantage of the antimicrobial essential oils is that they can give a good odor to the disinfecting compositions of the present invention without the addition of fragrances. Indeed, the disinfecting compositions according to the present invention not only provide good disinfection safely to a clean surface to be disinfected, but also provide a good aroma.

Antimicrobial essential oils suitable for use herein include thyme, lemongrass, citrus fruits, lemons, oranges, anise, cloves, anise fruit, cinnamon, herb, rose, mint, peppermint, Lavender, Citronella, Eucalyptus, Peppermint, Camphor, Sandalwood, Himalayan Cedar, Rosemary, Pine, Verbena, Fleagrass, Lemongrass, Ratanhiae ) And mixtures thereof, but is not limited thereto. Especially preferred for use herein are eucalyptus oil, timmy oil, clove oil, cinnamon oil, balsam oil, eucalyptus oil, peppermint oil, mint oil and mixtures thereof.

The composition of the present invention comprising 0.1 to 15% by weight of hydrogen peroxide, and the antimicrobial essential oil or mixtures thereof, has a clean surface even when used in a high proportion when compared to the same composition containing peracid instead of hydrogen peroxide. It has recently been found to impart improved safety to hard surfaces and surfaces, including textiles such as silk, wool, while providing excellent disinfection properties.

An advantage associated with the present invention is that when the composition is used to disinfect colored fabrics, even when diluted in a high proportion, it gives the fabric excellent disinfection and at the same time reduces color damage. Indeed, the color change and / or discoloration observed when treating colored fabrics with a composition according to the invention comprising hydrogen peroxide and said antimicrobial essential oils or mixtures thereof is observed when using the same composition containing peracid instead of hydrogen peroxide. Compared with color change and / or discoloration, even when used in a dilute state with a high proportion, it is reduced while giving the fabric excellent disinfection performance.

Surface safety can be evaluated on the surface of the fabric or the like by measuring the tensile strength of the fabric. Tensile strength of the fabric can be measured by using the "Tensile Strength method". The method consists in measuring the tensile strength of the fabric by stretching it until the desired fabric breaks. The force required to rupture the fabric, expressed in Kg, is "Ultimate Tensile Stress" and can be measured by "The Stress-Strain INSTRON Machine".

With the compositions of the present invention, even when used at high rates of dilution, star as well as fungi such as Candida albicans are present on a clean surface, i.e., any surface with little organic and / or inorganic contaminants. Excellent disinfection is achieved against various microorganisms, including Gram-positive bacteria such as Staphylococcus aureus and Gram-negative bacteria such as Pseudomonas aeroginosa.

Disinfection of a composition can be measured by the bactericidal activity of the composition. Suitable test methods for evaluating the bactericidal activity of the composition on clean surfaces are published in November 1995 by the European Committee for standardisation of Brussels [European Standard, prEN 1040, CEN / TC 216 N 78]. The European Standard, prEN 1040, CEN / TC 216 N 78 specifies test methods and requirements for the minimal bactericidal activity of disinfectant compositions. If the bacterial colony forming unit (cfu) decreases from 10 ⁷ cfu (initial level) to 10 ² cfu (final level after contact with the sterilization product), then the test passes, i.e. a reduction in growth of 10 ⁵ is essential. . The composition according to the present invention passes the test under clean conditions even when used at high rates of dilution.

Other methods suitable for evaluating the bactericidal activity of the present composition on clean surfaces are AFNOR T72-190® and T72-301®.

In a preferred embodiment, the composition according to the invention is an aqueous liquid cleaning composition. The pH of the aqueous composition is preferably 12.0 or less, more preferably 2-6, most preferably 3-5. The pH of the composition can be adjusted by using organic acids, such as citric acid, succinic acid, acetic acid, aspartic acid, lactic acid, or inorganic or alkalizing agents.

The compositions of the present invention may further comprise surfactants known to those skilled in the art, including nonionic, anionic, cationic, zwitterionic and / or zwitterionic surfactants.

Typically, the composition according to the invention comprises up to 50% by weight of the total composition, preferably from 0.01 to 30% by weight, more preferably from 0.1 to 25% by weight of the surfactant or mixtures thereof.

Accordingly, it may be desirable for the composition of the present invention to include an amphoteric surfactant or mixtures thereof. Zwitterionic surfactants suitable for use herein include betaine and sulfobetaine surfactants, derivatives thereof, or mixtures thereof. The betaine or sulfobetaine surfactants are preferred herein because they contribute to the disinfectability of the composition. Indeed, these surfactants increase the permeability of bacterial cell walls to aid disinfection by allowing other active ingredients to enter the cell.

In addition, due to the mild action profile of the betaine or sulfobetaine surfactants, the present compositions comprising these surfactants are suitable for cleaning delicate surfaces, such as demanding laundry, or hard surfaces in contact with food and / or infants. It may be particularly suitable. In addition, betaine and sulfobetaine surfactants are very mild to the skin and / or surface to be treated.

Betaines and sulfobetaine surfactants suitable for use in the compositions of the present invention contain betaines, which contain both basic and acidic groups, thereby forming internal salts that allow molecules to provide cationic and anionic hydrophilic groups over a wide pH range. Sulfobetaine and betaine detergents. Some typical examples of such detergents are described in US Pat. Nos. 2,082,275, 2,702,279, and 2,255,082, which are incorporated herein by reference. Preferred betaine and sulfobetaine surfactants are compounds of Formula 1 or mixtures thereof:

Where

R 1 is an alkyl radical of C ₁ -C ₂₄ , preferably C ₈ -C ₁₈ , more preferably C ₁₂ -C ₁₄ ,

R2 and R3 contain C ₁ -C ₃ , preferably C ₁ ,

n is 1 to 10, preferably 1 to 6, more preferably an integer of 1,

Y is selected from the group consisting of carboxyl and sulfonyl radicals,

The sum of the R 1, R 2 and R 3 radicals is from about 14 to about 24 carbon atoms.

Examples of particularly suitable betaine surfactants include C ₁₂ -C ₁₈ alkyl dimethyl betaine such as coconut betaine, and C ₁₀ -C ₁₆ alkyl dimethyl betaine such as laurylbetaine.

Coconut betaine is sold by Seppic under the trade name Amonyl 265®. Laurylbetaine is sold by Albright & Wilson under the tradename Empigen® BB / L.

Other zwitterionic surfactants suitable for use herein include amine oxides or mixtures thereof. Amine oxides are preferred herein because they contribute to the disinfectability of the compositions. Indeed, amine oxides help disinfection by disrupting the cell wall / membrane of bacteria so that other antimicrobial components can enter the cell, for example by attacking the interior of the cell.

Suitable amine oxides for use herein have the formula R ₁ R ₂ R ₃ NO, wherein R ₁ , R ₂ and R ₃ are each independently a linear or branched saturated hydrocarbon chain of C ₁ -C ₃₀ . . Suitable amine oxides for use in accordance with the invention are formulas R ₁ R ₂ R ₃ NO, wherein R ₁ is C ₁ -C ₃₀ , preferably C ₆ -C ₂₀ , more preferably C ₆ -C ₁₄ , Most preferably a C ₈ -C ₁₀ hydrocarbon chain, R ₂ and R ₃ are independently C ₁ -C ₄ , preferably C ₁ -C ₃ substituted or unsubstituted linear or branched hydrocarbon chains, More preferably a methyl group). R ₁ is a linear or branched saturated hydrocarbon chain.

Preferred amine oxides for use herein are, for example, natural blends of C ₈ -C ₁₀ amine oxides and C ₁₂ -C ₁₆ amine oxides commercially available from Hoechst.

In a preferred embodiment of the invention in which the composition is particularly suitable for disinfecting hard surfaces, the surfactants typically comprise amine oxides and betaine or sulfobetaine surfactants, preferably 2: 1 to 100: 1, more preferably Preferably a surfactant system comprising a weight ratio of 6: 1 to 100: 1, most preferably 10: 1 to 50: 1. The use of such surfactant systems in the present compositions suitable for disinfecting hard surfaces provides effective cleaning performance and gloss of cleaned surfaces to minimize the amount of thin film / stripes remaining on the cleaned surfaces treated with the composition.

It may also be desirable for the composition to include anionic surfactants or mixtures thereof. Particularly suitable anionic surfactants for use herein are alkyl or hydroxyalkyl having an alkyl component of the formula ROSO ₃ M, wherein R is preferably C ₆ -C ₂₄ hydrocarbyl, preferably C ₈ -C ₂₀ , More preferably C ₈ -C ₁₆ alkyl or hydroxyalkyl; M is H, or an alkali metal cation (eg sodium, potassium, lithium), ammonium or substituted ammonium (eg methyl-, dimethyl- and trimethyl Ammonium cations and quaternary ammonium cations such as quaternary ammonium cations derived from tetramethyl-ammonium and dimethyl pipedinium cations and alkylamines such as ethylamine, diethylamine, triethylamine and mixtures thereof) It includes.

Other anionic surfactants suitable for use herein include alkyl-diphenyl-ether-sulfonates and alkyl-carboxylates. Other anionic surfactants include salts of soap (eg, substituted ammonium salts such as sodium, potassium, ammonium, and monoethanolamine salts, diethanolamine salts and triethanolamine salts), C ₉ -C ₂₀ linear alkylbenzenes Sulfonated polys prepared by sulfonating a pyrrolation product of an alkaline earth metal citrate as described in sulfonates, C ₈ -C ₂₂ primary or secondary alkanesulfonates, C ₈ -C ₂₄ olefinsulfonates, British Patent No. 1,082,179 Carboxylic acid, C ₈ -C ₂₄ alkylpolyglycol ether sulfate (containing 10 mol or less of ethylene oxide); Alkyl ester sulfonates such as C ₁₄ -C ₁₆ methyl ester sulfonates; Acyl glycerol sulfonate, fatty oleyl glycerol sulfate, alkyl phenol ethylene oxide ether sulfate, paraffin sulfonate, alkyl phosphate, isethionate such as acyl isethionate, N-acyl taurate, alkyl succinamate and alkyl sulfosuccisine , Monoesters of sulfosuccinates (especially saturated and unsaturated C ₁₂ -C ₁₈ monoesters), diesters of sulfosuccinates (especially saturated and unsaturated C ₆ -C ₁₄ diesters), acyl sarcosinates, alkyls Sulfates of alkylpolysaccharides such as those of polyglucosides (nonionic unsulfated compounds are described below), branched primary alkyl sulfates, compounds of the formula RO (CH ₂ CH ₂ O) _k CH ₂ COO-M ⁺ ethoxy carboxylate reyiteuyi alkyl, such as poly - (wherein, R is a C ₈ -C ₂₂ alkyl, k is an integer from 0 to 10, M is a water-soluble salt forming cation) . Resin acids and hydrogenated resin acids are also suitable, such as hydrogenated rosin acids present in or derived from rosin, hydrogenated rosin, resin acids and tall oils. Further examples are provided in Surface Active Agents and Detergents, Vol I and II, by Schwartz, Perry and Berch. Such various surfactants are also generally described in US Pat. No. 3,929,678, column 23, lines 58 to 29 column 23, issued December 30, 1975 to Laughlin et al.

Preferred anionic surfactants for use in the compositions include C ₈ -C ₁₆ alkyl sulfonates, C ₈ -C ₁₆ alkyl sulfates, C ₈ -C ₁₆ alkyl alkoxylated sulfates (eg, C ₈ -C ₁₆ alkyl ethoxylated sulfates). ) And mixtures thereof. Such anionic surfactants are preferred herein because they have been found to contribute to the disinfectability of disinfectant compositions comprising hydrogen peroxide and / or antimicrobial essential oils. For example, C ₈ -C ₁₆ alkyl sulfates act to disrupt bacterial cell membranes, inhibit enzymatic activity, interfere with cellular transport and / or denature cytoplasmic proteins. Indeed, for example, improved disinfection associated with the addition of anionic surfactants, in particular C ₈ -C ₁₆ alkyl sulfonates, C ₈ -C ₁₆ alkyl sulfates and / or C ₈ -C ₁₆ alkyl alkoxylated sulfates, in the compositions of the invention The ability tends to be due to the complex mode of attack of these surfactants against bacteria. Accordingly, another aspect of the present invention is an anionic surfactant, in particular C ₈ -C ₁₆ alkyl sulfonate, C ₈ -C ₁₆ alkyl sulfate and / or C ₈ -in a disinfecting composition comprising hydrogen peroxide and / or antimicrobial essential oils. C ₁₆ alkyl alkoxylated sulfates are used to improve the disinfection of the composition against Gram-negative and / or Gram-positive bacteria.

Suitable nonionic surfactants for use herein are commercial fatty alcohol ethoxylates and / or propoxylates having various fatty alcohol chain lengths and various degrees of ethoxylation. Indeed, the HLB value of such alkoxylated nonionic surfactants depends essentially on the chain length of the fatty alcohol, the nature of the alkoxylation and the degree of alkoxylation. A list of surfactants is commercially available, listing a number of surfactants, including nonionic surfactants, with each HLB.

Nonionic surfactants are particularly suitable for use herein with hydrophobic nonionic surfactants having a hydrophilic-lipophilic balance (HLB) of less than 16, preferably less than 15, more preferably less than 14. Hydrophobic nonionic surfactants have been found to provide good oily cleavage.

Preferred hydrophobic nonionic surfactants for use in the compositions according to the invention are those having the formula RO- (C ₂ H ₄ O) n (C ₃ H ₆ O) mH, wherein R is C ₆ -C An alkyl chain of ₂₂ or an alkyl benzene chain of C ₆ -C ₂₈ , n + m is 0 to 20, n is 0 to 15, m is 0 to 20, preferably n + m is 1 to 15, n and m are 0.5 to 15, more preferably n + m is 1 to 10 and n and m are 0 to 10). Preferred R chains for use herein are C ₈ -C ₂₂ alkyl chains. Accordingly, hydrophobic nonionic surfactants suitable for use herein are Dobanol ^R 91-2.5 (HLB = 8.1; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 2.5, m is 0 Or Lutensol ^R TO3 (HLB = 8; R is a C ₁₃ alkyl chain, n is 3 and m is 0), Lutensol ^R AO3 (HLB = 8; R is C ₁₃ and C ₁₅ Is a mixture of alkyl chains, n is 3, m is 0, tergitol ^R 25L3 (HLB = 7.7; R is in the range of alkyl chain lengths of C ₁₂ to C ₁₅ , n is 3, m Is 0), dovanol ^R 23-3 (HLB = 8.1; R is a mixture of C ₁₂ and C ₁₃ alkyl chains, n is 3, m is 0), dovanol ^R 23-2 (HLB = 6.2; R is a mixture of alkyl chains of C ₁₂ and C ₁₃ , n is 2, m is 0, dobanol ^R 45-7 (HLB = 11.6; R is a mixture of alkyl chains of C ₁₄ and C ₁₅₎ , N is 7, m is 0, dovanol ^R 23-6.5 (HLB = 11.9; R is a mixture of alkyl chains of C ₁₂ and C ₁₃ , n is 6.5, m is 0), Dovanol All ^R 25-7 ( HLB = 12; R is a mixture of C ₁₂ and C ₁₅ alkyl chains, n is 7 and m is 0), dovanol ^R 91-5 (HLB = 11.6; R is alkyl chain of C ₉ and C ₁₁₎ , N is 5, m is 0), dobanol ^R 91-6 (HLB = 12.5; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 6, m is 0) , Dovanol ^R 91-8 (HLB = 13.7; R is a mixture of alkyl chains of C ₉ and C ₁₁ , n is 8, m is 0), dovanol ^R 91-10 (HLB = 14.2; R is A mixture of alkyl chains of C ₉ -C ₁₁ , n is 10 and m is 0) or mixtures thereof. Doban ol ^R 91-2.5, ruten Sol ^R TO3, ruten Sol ^R AO3, Terre gitol ^R 25L3, doban ol ^R 23-3, ^R 23-2 is doban ol, or a mixture thereof. Dovanol ^R surfactants are commercially available from SHELL. Lutensol ^R surfactants are commercially available from BASF, and Tergitol ^A surfactants are commercially available from UNION CARBIDE.

In addition, other suitable surfactants include the (alkali metal salts, preferably sodium salts of C ₆ -C ₂₀ fatty acid) C ₆ -C ₂₀ conventional soaps.

The composition according to the present invention may further comprise an antimicrobial component as any desired component that contributes to the antimicrobial activity of the composition of the present invention. Such antimicrobial components include parabens such as ethyl paraben, propyl paraben, methyl paraben, glutaraldehyde or mixtures thereof.

The composition may further comprise a chelating agent as any desired component. Suitable chelating agents include phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, multifunctionally substituted aromatic chelating agents, biodegradable chelating agents ( Such as ethylene diamine N, N'-disuccinic acid), or mixtures thereof, may be any known to those skilled in the art.

Phosphonate chelating agents suitable for use herein include etidronic acid (1-hydroxyethylene-diphosphonic acid (HEDP)) and / or alkali metal ethane 1-hydroxydiphosphonate.

Amino phosphonate chelating agents suitable for use herein are amino alkylene poly (alkylene phosphonates), nitrilotris (methylene) triphosphonates, ethylene diamine tetra methylene phosphonates and / or diethylene triamine Penta methylene phosphonate. Preferred aminophosphonate chelating agents for use herein are diethylene triamine penta methylene phosphonates.

These phosphonate / amino phosphonate chelating agents may be present in their acid form or as salts of different cations in some or all of their acid functionalities. Such phosphonate / amino phosphonate chelating agents are commercially available from Monsanto under the trade name DEQUEST®.

As used herein, substituted heteroaromatic chelating agents include hydroxypyridine-N-oxides or derivatives thereof.

Suitable hydroxy pyridine N-oxides and derivatives thereof used according to the invention have the formula:

Where

X is nitrogen,

Y is one member selected from the group consisting of oxygen, -CHO, -OH,-(CH ₂ ) _n -COOH, preferably oxygen,

n is an integer of 0 to 20, preferably 0 to 10, more preferably 0.

Thus, particularly preferred hydroxy pyridine N-oxides and derivatives thereof as used herein are 2-hydroxy pyridine N-oxides.

Hydroxy pyridine N-oxides and derivatives thereof are derivatives which may be commercially available from Sigma.

Multifunctionally substituted aromatic chelating agents may also be useful in the present compositions. See US Patent No. 3,812,044, issued May 21, 1974 to Connor et al. Preferred compounds of this type in acid form are dihydroxydisulfobenzenes such as 1,2-dihydroxy-3,5-disulfobenzene.

Preferred biodegradable chelating agents for use herein are ethylene diamine N, N'-disuccinic acid or its alkali or alkaline earth metal salts, ammonium salts or substituted ammonium salts, or mixtures thereof. Ethylenediamine N, N'-disuccinic acid, in particular (S, S) isomers, is described extensively in US Pat. No. 4,704,233, issued November 3, 1987 to Hartman and Perkins. Ethylenediamine N, N'-disuccinic acid is commercially available, for example, under the name ssEDDS® from Palmer Research Laboratories. Ethylene diamine N, N'-disuccinic acid is particularly suitable for use in the compositions of the present invention.

Suitable amino carboxylate chelating agents useful herein are ethylene diamine tetra acetate, diethylene triamine pentaacetate, diethylene triamine pentoacetate (DTPA), N-hydroxyethylethylenediamine triacetate, nitrilotriacetate, ethylene diamine tetraprop Prionate, triethylenetetraaminehexa-acetate, ethanol diglycine, propylene diamine tetraacetic acid (PDTA) and methyl glycine diacetic acid (MGDA) in acid form, or salt forms of their alkali metals, ammonium and substituted ammonium Includes as both. Diethylene triamine penta acetic acid (DTPA) such as propylene diamine tetraacetic acid (PDTA), and methyl glycine diacetic acid (MGDA), sold by BASF under the trade name Trilon FS®, are used herein. Particularly suitable for

Additional carboxylate chelating agents as used herein include malonic acid, salicylic acid, glycine, aspartic acid, glutamic acid or mixtures thereof.

Such chelating agents, in particular phosphonate chelating agents such as diethylene triamine penta methylene phosphonate, are known to further contribute to the disinfectability of hydrogen peroxide and are therefore particularly preferred in the compositions according to the invention. Thus, another aspect of the present invention is a chelating agent, particularly a phospho such as diethylene triamine penta methylene phosphonate, in disinfecting compositions comprising hydrogen peroxide to improve the disinfection of the composition against Gram negative and / or Gram positive bacteria. Nate chelating agent.

Typically the composition according to the invention comprises up to 5%, preferably 0.002 to 3%, more preferably 0.002 to 1.5% by weight of chelating agent or mixtures thereof.

The compositions herein may comprise a radical scavenger as any of the preferred components. Suitable radical scavengers for use herein include well known substituted monohydroxybenzenes and dihydroxy benzenes and derivatives thereof, alkyl carboxylates, aryl carboxylates and mixtures thereof. Preferred radical scavengers for use herein are di-tert-butyl hydroxy toluene (BHT), p-hydroxy-toluene, hydroquinone (HQ), di-tert-butyl hydroquinone (DTBHQ), mono-tertiary -Butyl hydroquinone (MTBHQ), tert-butyl-hydroxy anisole (BHA), p-hydroxy-anisole, benzoic acid, 2,5-dihydroxy benzoic acid, 2,5-dihydroxyterephthalic acid, toluic acid , Catechol, t-butyl catechol, 4-allyl-catechol, 4-acetyl catechol, 2-methoxy-phenol, 2-ethoxy-phenol, 2-methoxy-4- (2-propenyl) Phenol, 3,4-dihydroxy benzaldehyde, 2,3-dihydroxy benzaldehyde, benzylamine, 1,1,3-tris (2-methyl-4-hydroxy-5-t-butylphenyl) butane, 3 Tert-butyl hydroxy aniline, p-hydroxy aniline and n-propyl-gallate. Di-tert-butyl hydroxy toluene (e.g., sold under the trade name IONOL CP® by Shell) and / or tert-butyl-hydroxy anisole are very preferred. These radical scavengers further contribute to the stability of the present compositions containing hydrogen peroxide.

Typically, the compositions according to the invention comprise up to 5% by weight of the total composition, preferably 0.001 to 1.5% by weight, more preferably 0.01 to 1% by weight of the radical scavengers or mixtures thereof.

The composition may comprise a solvent or mixtures thereof as any desired component. If a solvent is used, this advantageously improves the detergency of the present composition. Suitable solvents for incorporation into the compositions according to the invention include propylene glycol derivatives such as n-butoxypropanol or n-butoxypropoxypropanol; Water soluble Carbitol® solvents or water soluble Cellosolve® solvents. Water-soluble carbitol® solvents are compounds of 2- (2-alkoxyethoxy) ethanol in which the alkoxy group is derived from ethyl, propyl or butyl. Preferred water-soluble carbitol is 2- (2-butoxyethoxy) ethanol, also known as butyl carbitol. The water-soluble cellosolve (trademark) solvent is a compound of 2-alkoxyethoxyethanols, and 2-butoxyethoxyethanol is preferable. Other suitable solvents are benzyl alcohol, methanol, ethanol, isopropyl alcohol, diols such as 2-ethyl-1,3-hexanediol, 2,2,4-trimethyl-1,3-pentanediol and mixtures thereof . Preferred solvents for use herein are n-butoxypropoxypropanol, butyl carbitol® and mixtures thereof. Most preferred solvents for use herein are butyl carbitol®, benzyl alcohol and isopropanol.

The solvent may typically be present in the composition of the present invention in an amount of up to 15% by weight, preferably 2 to 7% by weight of the composition.

The composition includes buffers (e.g. borate buffers), builders, stabilizers, bleach activators, contaminant suspensions, dye transfer agents, brighteners, fragrances, antidust agents, enzymes, dispersants, dye transfer inhibitors, pigments, perfumes And various other optional ingredients such as dyes.

Packing form of the composition

The composition may be packaged in a variety of suitable detergent packages known to those skilled in the art. The liquid composition may preferably be packaged in a manually operated spray spray container which is generally made of synthetic organic polymeric plastics material. Accordingly, the present invention also includes a liquid disinfecting composition comprising hydrogen peroxide, and an antimicrobial essential oil, packaged in a spray dispenser, preferably a trigger spray dispenser or a pump spray dispenser.

Indeed, the spray dispenser makes it possible to uniformly apply a liquid disinfecting composition suitable for use according to the invention to a surface of a relatively large area to be disinfected, thereby contributing to the disinfectability of the composition. Such spray dispensers are particularly suitable for disinfecting vertical surfaces.

Spray dispensers suitable for use in accordance with the invention are, for example, manually operated by Specialty Packaging Products, Inc. or Continental Sprayers, Inc. Effervescent triggered dispensers. Dispensers of this type are described, for example, in US Pat. No. 4,701,311 to Duning et al. And US Pat. No. 4,646,973 to Pokarracci and US Pat. No. 4,538,745. Spray dispensers such as the T 8500® or T 8900® available from Continental Spray International, or the T 8100® available from Canyon, Ireland, are used herein. Especially preferred. In such dispensers the liquid composition is divided into fine liquid droplets and sprayed towards the surface to be treated. In practice, in such spray dispensers, the composition contained in the dispenser container is sprayed through the head of the spray dispenser by the energy delivered by the user to the pumping mechanism when the user activates the pumping mechanism. More specifically, in the sprayed dispenser head, the composition is pressed against an obstruction such as a lattice or cone, providing an impact to refine the liquid composition to help form liquid droplets.

The compositions of the present invention may also be practiced in the form of wipes. By “wipe” is meant herein a disposable towel immersed in the liquid composition according to the invention. Accordingly, the present invention also includes wipes, such as disposable paper towels, immersed in the liquid composition according to the present invention. In a preferred implementation, the wipe is wetted by the liquid composition. Preferably the wipe is packaged in a plastic box. An advantage of doing this is that the user can use the disinfecting composition more quickly, even outside the home, ie there is no need to pour the liquid composition according to the invention on the surface to be treated / disinfected and dry it with a cloth. In other words, the wipe allows the surface to be disinfected in one step.

Disinfection Method

The invention includes a method for disinfecting a surface, by applying a composition according to the invention to a surface.

"Surface" herein means any surface, including human skin, oral cavity, surfaces of living things such as teeth, and inanimate surfaces. Inanimate surfaces are hard surfaces typically found in homes or cars such as kitchens and bathrooms, such as tiles, walls, floors, chrome, glass, flat vinyl, any plastics, plasticized wood, table tops, sinks, countertops. Fabrics such as clothing, curtains, thin curtains, bed linens, bathroom linens, tablecloths, sleeping bags, tents, covered furniture, as well as tops, plates, sanitary parts (e.g. sinks, showers, shower curtains, washbasins, WC, etc.); Carpets and the like, but is not limited thereto. In addition, the inanimate surface includes, but is not limited to, household appliances including refrigerators, freezers, washing machines, automatic dryers, ovens, microwave ovens, dishwashers, and the like.

In the method of disinfecting a surface according to the invention, the composition can be applied to the surface to be disinfected in undiluted or diluted form.

As used herein, "diluted form" means that a composition in liquid or solid form for use in the disinfection methods herein is diluted by the user with up to 100 times its weight, preferably 80 to 30 times, more preferably 60 to 40 times water. It can be.

In a preferred embodiment of the method of the invention wherein the composition is applied to a hard surface to be disinfected in diluted form, the surface does not have to be washed off after applying the composition and in fact no visible residue remains on the surface.

The invention will be further illustrated by the following examples.

The following compositions were prepared by mixing the listed ingredients in the listed ratios (% by weight unless otherwise indicated). These compositions passed the prEN 1040 test of the European Standardization Community. These compositions provide good disinfection performance when used undiluted on clean surfaces or when diluted to dilution levels of 1: 100, 1:25, 1:50, while exhibiting good surface safety and non-irritancy to the skin.

Composition I II III IV V VI Hydrogen peroxide 7.0 6.0 6.0 6.0 2.0 7.0 Timmy 0.5 - - 0.5 - 0.5 Clove oil - 1.0 - - 0.1 0.5 Brown colostrum 0.5 - - - - Eucalyptus - - 1.0 - - 0.5 Water, trace substance Remainder Remainder Remainder Remainder Remainder Remainder PH below ₄ with H ₂ SO ₄

Composition VII VIII IX X Hydrogen peroxide 7.0 6.0 1.0 2.0 Timmy - 0.5 - - Clove Oil / Yukkail Oil (1: 1) 1.0 - 0.5 0.05 Brown colostrum - 0.5 - - Water, trace substance Remainder Remainder Remainder Remainder PH below ₄ with H ₂ SO ₄

Composition XI XII XIII XIV XV Hydrogen peroxide 7.0 6.0 1.0 2.0 1.0 C ₁₀ alkyl sulfate 3.0 4.0 - 1.5 - C ₁₀ amine oxide 1.5 - 1.5 - 0.9 Lauryl betaine - - - - 0.05 Timmy - 0.5 - - 0.03 Eucalyptus - - - - 0.02 Clove Oil / Yukkail Oil (1: 1) 1.0 - 0.5 0.05 - Brown colostrum - 0.5 - - - Water, trace substance Remainder Remainder Remainder Remainder Remainder PH below ₄ with H ₂ SO ₄

Claims (16)

A disinfection composition comprising from 0.1 to 15% by weight of hydrogen peroxide and an antimicrobial essential oil or mixtures thereof. The method of claim 1, A composition comprising from 0.5 to 10% by weight of hydrogen peroxide, preferably from 1 to 8% by weight of the total composition. The method according to claim 1 or 2, The antimicrobial essential oils are thyme oil, lemongrass oil, citrus oil, lemon oil, orange oil, anise oil, clove oil, anise fruit oil, cinnamon oil, vinegar oil, Rose oil, lavender oil, citronella oil, eucalyptus oil, peppermint oil, mint oil, camphor oil, sandalwood oil, Himalayas Cedar oil, rosmarin oil, pine oil, Verbena oil, fleagrass oil, ratanhiae oil and / or mixtures thereof, preferably thyme oil, cloves oil, cinnamon oil, brown rice oil, Eucalyptus oil, peppermint oil, mint oil or a mixture thereof. The method according to any one of claims 1 to 3, A composition comprising at least 0.003%, preferably 0.006 to 10%, most preferably 0.2 to 4% by weight of said antimicrobial essential oil or mixtures thereof. The method according to any one of claims 1 to 4, A surfactant selected from the group consisting of anionic surfactants, nonionic surfactants, cationic surfactants, zwitterionic surfactants, zwitterionic surfactants, or mixtures thereof, may comprise up to 50% by weight of the total composition, preferably 0.01 To 30% by weight, more preferably from 0.1 to 25% by weight. The method of claim 5, The surfactant is an amphoteric surfactant or a mixture thereof, preferably a betaine or sulfobetaine surfactant or a derivative thereof or a mixture thereof, and / or a formula R ₁ R ₂ R ₃ NO, wherein R ₁ , R ₂ and R ₃ are each independently a linear or branched saturated hydrocarbon chain of C ₁ -C ₃₀ , preferably C ₆ -C ₂₀ ; R ₂ and R ₃ are independently C ₁ -C ₄ , Preferably an amine oxide of a C ₁ -C ₃ substituted or unsubstituted linear or branched hydrocarbon chain, more preferably a methyl group): Formula 1 Where R 1 is an alkyl radical of C ₁ -C ₂₄ , preferably C ₈ -C ₁₈ , more preferably C ₁₂ -C ₁₄ , R2 and R3 contain C ₁ -C ₃ , preferably C ₁ , n is 1 to 10, preferably 1 to 6, more preferably an integer of 1, Y is selected from the group consisting of carboxyl and sulfonyl radicals, The sum of the R 1, R 2 and R 3 radicals is from about 14 to about 24 carbon atoms. The method according to any one of claims 1 to 6, And another antimicrobial component selected from the group consisting of glutaraldehyde, ethyl paraben, propyl paraben, methyl paraben and mixtures thereof. The method according to any one of claims 1 to 7, Phosphonate chelating agents, aminophosphonate chelating agents, substituted heteroaromatic chelating agents, aminocarboxylate chelating agents, other carboxylate chelating agents, multifunctionally substituted aromatic chelating agents, ethylene diamine N, N'-disuccinic acid And a chelating agent selected from the group consisting of a mixture thereof. The method according to any one of claims 1 to 8, Radical scavengers, solvents, buffers, builders, stabilizers, bleach activators, contaminant suspensions, dye transfer agents, brighteners, fragrances, dust inhibitors, enzymes, dispersants, dye transfer inhibitors, pigments, dyes and their At least one optional component selected from the group consisting of mixtures. The method according to any one of claims 1 to 9, A liquid composition, preferably a composition which is an aqueous composition having a pH of 12 or less, preferably less than 7, more preferably 2 to 6 and most preferably 3 to 5. Wipes dipped in disinfectant composition according to claim 10 The method of claim 10, Disinfection composition packaged in a spray dispenser. A method for disinfecting said surface, wherein the composition according to any one of claims 1 to 10 is applied to any surface. The method of claim 13, Applying the composition to the surface after diluting the composition with 100 times or less, preferably 80 to 40 times, more preferably 60 to 30 times, water by weight. Chelating agents, preferably phosphonate chelating agents, more preferably diethylene triamine pentamethylene phosphate in the composition for improving disinfection of Gram-negative and / or Gram-positive bacteria in a disinfecting composition comprising hydrogen peroxide Use of fonate chelating agent. Anionic surfactants, in particular C ₈ -C ₁₆ alkyl sulfonates, C ₈ -in the compositions for improving the disinfection of Gram-negative and / or Gram-positive bacteria in disinfecting compositions comprising hydrogen peroxide and / or antimicrobial essential oils. Use of C ₁₆ alkyl sulfates and / or C ₈ -C ₁₆ alkyl alkoxylated sulfates.