KR20100023155A - Filter for removing a white corpuscle and method of manufacturing the same - Google Patents
Filter for removing a white corpuscle and method of manufacturing the same Download PDFInfo
- Publication number
- KR20100023155A KR20100023155A KR1020080081776A KR20080081776A KR20100023155A KR 20100023155 A KR20100023155 A KR 20100023155A KR 1020080081776 A KR1020080081776 A KR 1020080081776A KR 20080081776 A KR20080081776 A KR 20080081776A KR 20100023155 A KR20100023155 A KR 20100023155A
- Authority
- KR
- South Korea
- Prior art keywords
- nonwoven fabric
- water
- leukocyte removal
- removal filter
- water dispersible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
- A61M1/3633—Blood component filters, e.g. leukocyte filters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0281—Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3496—Plasmapheresis; Leucopheresis; Lymphopheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0244—Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/75—General characteristics of the apparatus with filters
- A61M2205/7545—General characteristics of the apparatus with filters for solid matter, e.g. microaggregates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/02—Types of fibres, filaments or particles, self-supporting or supported materials
- B01D2239/0216—Bicomponent or multicomponent fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/02—Types of fibres, filaments or particles, self-supporting or supported materials
- B01D2239/025—Types of fibres, filaments or particles, self-supporting or supported materials comprising nanofibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/06—Filter cloth, e.g. knitted, woven non-woven; self-supported material
- B01D2239/0604—Arrangement of the fibres in the filtering material
- B01D2239/0618—Non-woven
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/06—Filter cloth, e.g. knitted, woven non-woven; self-supported material
- B01D2239/0604—Arrangement of the fibres in the filtering material
- B01D2239/0622—Melt-blown
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/06—Filter cloth, e.g. knitted, woven non-woven; self-supported material
- B01D2239/0604—Arrangement of the fibres in the filtering material
- B01D2239/0627—Spun-bonded
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/06—Filter cloth, e.g. knitted, woven non-woven; self-supported material
- B01D2239/0604—Arrangement of the fibres in the filtering material
- B01D2239/0631—Electro-spun
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/06—Filter cloth, e.g. knitted, woven non-woven; self-supported material
- B01D2239/065—More than one layer present in the filtering material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/10—Filtering material manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/12—Special parameters characterising the filtering material
- B01D2239/1216—Pore size
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
- B01D2239/12—Special parameters characterising the filtering material
- B01D2239/1233—Fibre diameter
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Nonwoven Fabrics (AREA)
- Filtering Materials (AREA)
Abstract
본 발명은 백혈구 제거용 필터 및 그의 제조방법에 관한 것으로서, 평균직경이 100~2,000㎚이고 수분산성 폴리머인 나노섬유들로 구성되며, 상기 나노섬유들 사이에 평균직경이 0.5~3㎛인 공극들이 형성되어 있고, 두께가 0.5~50㎛인 나노섬유 부직포(A)층을 포함하는 것을 특징으로 한다.The present invention relates to a leukocyte removal filter and a method for manufacturing the same, comprising an average diameter of 100-2,000 nm and nanofibers, which are water dispersible polymers, with pores having an average diameter of 0.5-3 μm between the nanofibers. It is formed, and characterized in that it comprises a nanofiber nonwoven fabric (A) layer having a thickness of 0.5 ~ 50㎛.
본 발명에 따른 백혈구 제거용 필터는 백혈구 제거율이 높고, 적혈구 또는 혈소판의 회수효율이 높고, 전기방사시 물을 용매로 사용하므로 혈액 안정성이 우수한 장점이 있다.The leukocyte removal filter according to the present invention has a high leukocyte removal rate, high recovery efficiency of red blood cells or platelets, and excellent water stability because water is used as a solvent during electrospinning.
Description
본 발명은 백혈구 제거용 필터 및 그의 제조방법에 관한 것으로서, 보다 구체적으로는 백혈구 제거율이 높고, 적혈구 또는 혈소판의 회수효율이 높고, 전기방사시 물을 용매로 사용하므로 혈액 안정성이 우수한 백혈구 제거용 필터 및 그의 제조방법에 관한 것이다.The present invention relates to a leukocyte removal filter and a method for manufacturing the same. More specifically, leukocyte removal filter having high leukocyte removal rate, high recovery efficiency of red blood cells or platelets, and excellent water stability because water is used as a solvent during electrospinning. And a method for producing the same.
백혈구제거필터는 수혈 부작용 억제를 위한 가장 적극적인 방법으로 일본, 미국, 유럽을 중심으로 사용의무화 추세에 있다.Leukocyte removal filter is the most active method for suppressing side effects of blood transfusion, and it is in the trend of being obliged to use mainly in Japan, USA and Europe.
종래의 백혈구제거필터는 주로 폴리에스테르계 폴리머에 의한 부직포로 구성되어 있다. 그러나, 백혈구제거율과 적혈구 또는 혈소판 회수율을 높이기 위하여 보다 극세한 동시에 혈액적합성이 우수한 섬유에 의한 필터 여과층의 구성이 필요하며, 일본의 도레이, 아사히 카세이 메디칼 가부시키가이샤, 미국의 e-Spin社 등에서 이에 대한 연구가 진행 중이다.The conventional leukocyte removal filter is mainly composed of a nonwoven fabric made of a polyester polymer. However, in order to increase leukocyte removal rate and erythrocyte or platelet recovery rate, a filter filtration layer made of finer and blood compatible fibers is required.Toray, Asahi Kasei Medical Co., Ltd., e-Spin Co., Ltd. Research is ongoing.
종래의 백혈구 제거용 필터는 대부분 태섬도의 섬유로 구성되는 부직포 층과 세섬도의 섬유로 구성되는 부직포 층으로 구성되어 있다. The conventional leukocyte removal filter is composed of a nonwoven fabric layer composed mostly of fibers of Taesumdo, and a nonwoven fabric layer composed of fibers of fineness.
그러나, 상기의 종래 백혈구 제거용 필터는 부직포내 섬유의 평균직경이 3㎛를 초과하기 때문에 백혈구 세포와의 접촉면적이 작아 백혈구 세포의 포집효율과 적혈구의 회수효율이 낮은 문제점이 있었다.However, the conventional leukocyte removal filter has a problem that the contact area with the white blood cells is small because the average diameter of the fibers in the nonwoven fabric is less than 3 μm, and the collection efficiency of the white blood cells and the recovery efficiency of the red blood cells are low.
이와 같은 문제점을 해결하기 위해서 전기방사 방식으로 제조되어 평균직경이 2,000㎚ 이하인 나노섬유들로 이루어진 부직포를 백혈구 제거용 필터로 사용하는 방안도 제안된바 있다.In order to solve this problem, a method of using a nonwoven fabric made of nanofibers manufactured by an electrospinning method with an average diameter of 2,000 nm or less as a leukocyte removal filter has also been proposed.
그러나, 폴리아미드, 폴리우레탄, 폴리비닐리덴디플루오라이드, 폴리스티렌, 폴리비닐아세테이트, 폴리아크릴로니트릴, 폴리메틸아크릴레이트 또는 이들의 공중합체 등과 같은 대부분의 합성 고분자는 전기방사용 방사용액 제조를 위해서는 디메틸포름아미드, 디메틸아세트아미드, 메틸렌클로라이드, 메틸에틸케톤, 개미산, 초산, 메타크레졸 등과 같은 유기용매에 용해시켜야 한다.However, most synthetic polymers, such as polyamide, polyurethane, polyvinylidenedifluoride, polystyrene, polyvinylacetate, polyacrylonitrile, polymethylacrylate or copolymers thereof, are used to prepare electrospinning spinning solutions. It should be dissolved in organic solvents such as dimethylformamide, dimethylacetamide, methylene chloride, methyl ethyl ketone, formic acid, acetic acid, methacresol and the like.
다시말해, 상기의 합성 고분자를 전기방사하여 나노섬유 부직포를 제조하기 위해서는 상기와 같은 유기용매를 사용해야 하므로, 나노섬유 부직포 제조 후 여러번의 수제공정을 거쳐도 나노섬유 부직포에는 유기용매가 잔존하게 된다.In other words, in order to produce the nanofiber nonwoven fabric by electrospinning the synthetic polymer, the organic solvent as described above must be used. Thus, the organic solvent remains in the nanofiber nonwoven fabric even after several handmade steps after the nanofiber nonwoven fabric is manufactured.
그로인해, 상기 나노섬유 부직포를 백혈구 제거용 필터로 사용시에는 잔존 유기용매로 인해 혈액이 요염되어 혈액 안전성이 저하되는 문제가 있었다.Therefore, when the nanofiber nonwoven fabric is used as a filter for removing leukocytes, there is a problem in that blood is contaminated due to the residual organic solvent and blood safety is lowered.
본 발명은 이와 같은 종래의 문제점들을 해소할 수 있도록 평균직경이 100~2,000㎚인 수분산성 폴리머 섬유(이하 "수분산성 폴리머 나노섬유"라고 한다)들로 구성되고, 상온에서 물에 불용성인 나노섬유 부직포를 포함하여 백혈구 제거용 필터는 백혈구 제거율이 높고, 적혈구 또는 혈소판의 회수효율이 높고, 전기방사시 물을 용매로 사용하므로 혈액 안전성이 우수한 백혈구 제거용 필터 및 이의 제조방법을 제공하고자 한다.The present invention is composed of water-dispersible polymer fibers (hereinafter referred to as "water-dispersible polymer nanofibers") having an average diameter of 100 ~ 2,000nm to solve these problems, and insoluble in water at room temperature The leukocyte removal filter including a nonwoven fabric has a high leukocyte removal rate, high recovery efficiency of red blood cells or platelets, and uses water as a solvent during electrospinning to provide a leukocyte removal filter having excellent blood safety and a method of manufacturing the same.
이와 같은 과제들을 달성하기 위한 본 발명의 백혈구 제거용 필터재는 평균직경이 100~2,000㎚이고 수분산성 폴리머인 나노섬유들로 구성되며, 상기 나노섬유들 사이에 평균직경이 0.5~3㎛인 공극들이 형성되어 있고, 두께가 0.5~50㎛인 나노섬유 부직포(A)층을 포함하는 것을 특징으로 한다.The leukocyte removal filter material of the present invention for achieving the above problems is composed of nanofibers having an average diameter of 100 ~ 2,000nm and a water dispersible polymer, the pores having an average diameter of 0.5 ~ 3㎛ between the nanofibers It is formed, and characterized in that it comprises a nanofiber nonwoven fabric (A) layer having a thickness of 0.5 ~ 50㎛.
본 발명에 따른 백혈구 제거용 필터의 제조방법은 수분산성 폴리머를 물에 10~30중량%의 농도로 분산시켜 수분산성 폴리머 분산액을 제조한 후, 상기 수분산성 폴리머 분산액에 폴리비닐알코올 수지를 10~30% 농도로 용해시켜 제조한 방사용액을 제조하는 공정; 상기 방사용액을 고전압이 걸려 있는 노즐(3)로 공급한 후, 상기 노즐(3)을 통해 노즐과 반대 전하를 갖는 고전압이 걸려 있는 컬렉터(4) 상에 전기방사하여 나노섬유들로 이루어진 나노섬유 부직포를 제조하는 공정; 제조된 나 노섬유 부직포를 100~180℃에서 열처리하는 공정; 및 열처리된 나노섬유 부직포(A)를 상온의 물에 1시간 이상 침지시켜 나노섬유 내 폴리비닐알코올을 제거하는 공정; 을 포함하는 것을 특징으로 한다.In the method for preparing a leukocyte removal filter according to the present invention, a water-dispersible polymer is dispersed in water at a concentration of 10 to 30% by weight to prepare a water-dispersible polymer dispersion, and then 10 to 10 polyvinyl alcohol resin in the water-dispersible polymer dispersion. Preparing a spinning solution prepared by dissolving at a concentration of 30%; After supplying the spinning solution to the nozzle (3) subjected to high voltage, the nanofiber made of nanofibers by electrospinning through the nozzle (3) on a high voltage collector (4) having a charge opposite to the nozzle Manufacturing a nonwoven fabric; Heat-treating the prepared nanofiber nonwoven fabric at 100 to 180 ° C; And immersing the heat treated nanofiber nonwoven fabric (A) in water at room temperature for at least 1 hour to remove polyvinyl alcohol in the nanofibers. Characterized in that it comprises a.
본 발명에 따른 백혈구 제거용 필터는 수분산성 폴리머인 나노섬유들로 이루어진 나노섬유 부직포를 포함하고, 유기용매 대신에 물을 용매로 사용하여 제조되기 때문에 백혈구 제거율이 높고, 적혈구 또는 혈소판의 회수효율이 높고, 전기방사시 물을 용매로 사용하므로 혈액 안정성이 우수하다.The leukocyte removal filter according to the present invention includes a nanofiber nonwoven fabric made of nanofibers, which are water-dispersible polymers, and is manufactured using water as a solvent instead of an organic solvent, and thus high leukocyte removal rate and high recovery efficiency of red blood cells or platelets. It is high, and blood stability is excellent because water is used as a solvent during electrospinning.
이하, 첨부한 도면 등을 통하여 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.
먼저, 본 발명에 따른 백혈구 제거용 필터는 상기의 수분산성 폴리머 나노섬유들로 구성된 부직포(이하 "나노섬유 부직포"라고 한다)를 포함한다.First, the leukocyte removal filter according to the present invention includes a nonwoven fabric (hereinafter referred to as "nanofiber nonwoven fabric") composed of the above water-dispersible polymer nanofibers.
상기의 수분산성 폴리머는 수분산성 폴리우레탄계 수지, 수분산성 폴리아크릴계 수지 또는 이들의 혼합물 등이다.The water dispersible polymer is a water dispersible polyurethane resin, a water dispersible polyacrylic resin, or a mixture thereof.
본 발명은 한정된 필터 공간내에서 백혈구 세포와의 접촉기회를 높혀 백혈구 세포의 포집효율을 높히기 위해서 상기 나노섬유 부직포(A)를 구성하는 수분산성 폴리머 나노섬유의 평균직경을 100~2,000㎚로 가늘게 한다.The present invention narrows the average diameter of the water dispersible polymer nanofibers constituting the nanofiber nonwoven fabric (A) to 100-2,000 nm in order to increase the contact chance with the white blood cells in the limited filter space and increase the collection efficiency of the white blood cells. .
수분산성 폴리머 나노섬유의 평균직경이 2,000㎚를 초과하는 경우에는 백혈 구 세포의 포집효율이 떨어지고, 100㎚ 미만인 경우에는 나노섬유 간의 미세공극 크기가 너무 작아져 포집된 백혈구가 상기 미세공극을 막아 적혈구 또는 혈소판의 공급이 어렵게 된다.If the average diameter of the water-dispersible polymer nanofibers exceeds 2,000 nm, the collection efficiency of the leukocytes is lowered. If the average diameter of the water-dispersible polymer nanofibers is less than 100 nm, the micropore size between the nanofibers is too small, and the collected leukocytes block the micropores to prevent red blood cells. Or platelet supply becomes difficult.
상기 나노섬유 부직포내에 형성된 공극의 평균직경은 0.5~3㎛, 보다 바람직하기로는 1.5~3㎛이다.The average diameter of the voids formed in the nanofiber nonwoven fabric is 0.5 to 3 µm, more preferably 1.5 to 3 µm.
상기 공극의 평균직경이 3㎛를 초과하면 백혈구 세포의 포집효율이 떨어지게 되고, 0.5㎛ 미만인 경우에는 상기 공극이 포집된 백혈구에 의해 쉽게 막혀 적혈구 또는 혈소판의 공급이 어렵게 될 수 있다.If the average diameter of the pores exceeds 3㎛ the collection efficiency of the white blood cells decreases, if less than 0.5㎛ may be difficult to supply red blood cells or platelets because the pores are easily blocked by the collected white blood cells.
상기 나노섬유 부직포의 두께는 0.5~50㎛, 보다 바람직하기로는 2~10㎛이다.The thickness of the nanofiber nonwoven fabric is 0.5 to 50 µm, more preferably 2 to 10 µm.
나노섬유 부직포의 두께가 상기 범위를 초과하는 경우에는 혈액통과에 따른 압력 손실이 너무 많아지고, 상기 범위 미만인 경우에는 백혈구 제거효율이 저하된다.When the thickness of the nanofiber nonwoven fabric exceeds the above range, the pressure loss due to blood passage is too large, and when the nanofiber nonwoven fabric is below the above range, the leukocyte removal efficiency is lowered.
한편, 본 발명에 따른 백혈구 제거용 필터는 앞에서 설명한 나노섬유 부직포(A) 상에 1~3층의 합성섬유 부직포(B,C)가 적층된 구조를 포함한다.On the other hand, the leukocyte removal filter according to the present invention includes a structure in which one to three layers of synthetic fiber nonwoven fabrics (B, C) are laminated on the nanofiber nonwoven fabric (A) described above.
도 1은 본 발명에 따른 백혈구 제거용 필터 일례의 단면 모식도이다.1 is a schematic cross-sectional view of an example of a leukocyte removal filter according to the present invention.
상기 합성섬유 부직포(B,C)들은 평균직경이 2㎛를 초과하는 통상의 태섬도 섬유들로 이루어지며, 폴리에스테르 멜트브로운 부직포, 폴리에스테르 스펀본드 부직포 또는 폴리에스테르 니들펀칭 부직포 등이다.The synthetic fiber nonwoven fabrics (B, C) are made of conventional Taesando fibers having an average diameter of more than 2 μm, and are polyester melt blown nonwoven fabrics, polyester spunbond nonwoven fabrics, or polyester needle punched nonwoven fabrics.
다음으로는 본 발명에 따른 백혈구 제거용 필터의 제조방법을 구체적으로 살펴본다.Next, look at the manufacturing method of the leukocyte removal filter according to the present invention in detail.
본 발명의 제조방법은 수분산성 폴리머를 물에 10~30중량%의 농도로 분산시켜 수분산성 폴리머 분산액을 제조한 후, 상기 수분산성 폴리머 분산액에 폴리비닐알코올 수지를 10~30% 농도로 용해시켜 제조한 방사용액을 제조하는 공정; 상기 방사용액을 고전압이 걸려 있는 노즐(3)로 공급한 후, 상기 노즐(3)을 통해 노즐과 반대 전하를 갖는 고전압이 걸려 있는 컬렉터(4) 상에 전기방사하여 나노섬유들로 이루어진 나노섬유 부직포를 제조하는 공정; 제조된 나노섬유 부직포를 100~180℃에서 열처리하는 공정; 및 열처리된 나노섬유 부직포(A)를 상온의 물에 1시간 이상 침지시켜 나노섬유 내 폴리비닐알코올을 제거하는 공정; 을 포함하는 것을 특징으로 한다.In the manufacturing method of the present invention, the water-dispersible polymer is dispersed in water at a concentration of 10 to 30% by weight to prepare a water-dispersible polymer dispersion, and then the polyvinyl alcohol resin is dissolved in the water-dispersible polymer dispersion at a concentration of 10 to 30%. Preparing a prepared spinning solution; After supplying the spinning solution to the nozzle (3) subjected to high voltage, the nanofiber made of nanofibers by electrospinning through the nozzle (3) on a high voltage collector (4) having a charge opposite to the nozzle Manufacturing a nonwoven fabric; Heat-treating the prepared nanofiber nonwoven fabric at 100 to 180 ° C; And immersing the heat treated nanofiber nonwoven fabric (A) in water at room temperature for at least 1 hour to remove polyvinyl alcohol in the nanofibers. Characterized in that it comprises a.
상기 수분산성 고분자 나노섬유 부직포(A)는 도 2에 도시된 전기방사 방식 등으로 제조할 수 있다.The water dispersible polymer nanofiber nonwoven fabric (A) may be prepared by the electrospinning method shown in FIG.
도 2는 본 발명에 포함된 수분산성 고분자 나노섬유 부직포(A)를 전기방사 방식으로 제조하는 공정 개략도이다.Figure 2 is a process schematic diagram of producing a water-dispersible polymer nanofiber nonwoven fabric (A) included in the present invention by an electrospinning method.
구체적으로, 방사액 주탱크(1) 내에 보관중인 수분산성 고분자의 방사용액을 계량펌프(2)를 사용하여 고전압이 걸려 있는 노즐(3)로 공급한 후, 상기 노즐(3)을 통해 방사용액을 고전압이 걸려 있는 컬렉터(4) 상으로 전기방사하여 수분산성 고분자 나노섬유를 형성하여, 이를 상기 컬렉터(4)에 적층시켜 나노섬유 부직포를 제조한다. Specifically, the spinning solution of the water dispersible polymer stored in the spinning main tank 1 is supplied to the
도 3은 본 발명에 포함된 수용성 폴리머 나노섬유 부직포(A) 표면의 전자현미경 사진이다.3 is an electron micrograph of the surface of the water-soluble polymer nanofiber nonwoven fabric (A) included in the present invention.
상기 방사용액은 수분산성 폴리머를 물에 10~30중량%의 농도로 분산시켜 수분산성 폴리머 분산액을 제조한 후, 상기 수분산성 폴리머 분산액에 폴리비닐알코올 수지를 10~30% 농도로 용해시켜 제조한다.The spinning solution is prepared by dispersing a water-dispersible polymer in water at a concentration of 10-30% by weight to prepare a water-dispersible polymer dispersion, and then dissolving a polyvinyl alcohol resin at a concentration of 10-30% in the water-dispersible polymer dispersion. .
상기 수분산성 폴리머 분산액내 수분산 폴리머의 농도는 중량기준으로 10~30중량%이며, 10중량% 미만일 경우에는 전기방사로 제조되는 나노섬유의 직경이 너무 가늘어져 필터로 적용시 나노섬유의 파괴가 일어나기 쉽게되고, 30중량%를 초과하는 경우에는 수분산성 폴리머 분산액내에 폴리비닐알코올을 용해시킬 때 방사용액의 농도가 너무 높아 전기방사성이 저하될 수 있다.The concentration of the water-dispersible polymer in the water-dispersible polymer dispersion is 10 to 30% by weight, and if less than 10% by weight, the diameter of the nanofibers produced by electrospinning is too thin so that the destruction of the nanofibers when applied as a filter When the polyvinyl alcohol is dissolved in the water-dispersible polymer dispersion, the concentration of the spinning solution may be too high and the electrospinning property may be lowered.
상기 폴리비닐알코올을 검화도가 85% 이하인 것이 물에 침지시 제거가 용이한 장점이 있으나, 본 발명에서는 폴리비닐알코올의 검화도를 특별하게 한정하지 않는다.The saponification degree of the polyvinyl alcohol having a saponification degree of 85% or less has the advantage of easy removal when immersed in water, but the saponification degree of the polyvinyl alcohol is not particularly limited in the present invention.
방사용액내 폴리비닐알코올의 함량(농도)는 중량기분으로 10~30중량%이며, 10중량% 미만인 경우 전기방사시 비드의 형성이 심하여 물성이 떨어지고, 30중량%를 초과하는 경우에는 방사용액의 점도가 너무 높아져 전기방사성이 나빠질 수 있다.The content (concentration) of polyvinyl alcohol in the spinning solution is 10 to 30% by weight, and if it is less than 10% by weight, the formation of beads during electrospinning is severe, resulting in poor physical properties. The viscosity may be so high that the electrospinability may deteriorate.
본 발명에서는 전기방사시 토출량, 전압, 분위기 온도, 습도 컬렉터와 노즐간의 거리, 노즐의 형태, 컬렉터의 이동속도 등은 특별하게 한정하지 않는다.In the present invention, the discharge amount, the voltage, the ambient temperature, the distance between the humidity collector and the nozzle, the shape of the nozzle, the moving speed of the collector, and the like during electrospinning are not particularly limited.
상기 노즐(3)과 컬렉터(4)에는 전압전달로드(5)를 통해 전압발생장치(6)에서 발생되는 고전압을 걸어준다.The high voltage generated by the voltage generator 6 is applied to the
본 발명에서 사용하는 전기방사 장치에는 특별히 제한하지 않는다. 도 2에서 보는 바와 같은 다중 노즐을 사용하는 전기방사 장치를 사용할 수 있으며 이 외의 다른 형태의 전기방사 장치 또한 사용할 수 있다. 전기방사 장치는 고분자 방사 용액을 공급하는 계량 펌프(2)와 다수의 노즐(3)로 구성되는 방사부, 고전압발생장치(6)에 의한 고전압발생부와 방사되어 휘산되는 나노섬유를 고착시키는 컬렉터(4)로 구성된다. 본 발명의 나노섬유를 방사하기 위한 발생전압은 수천 내지 수십만 볼트로 방사 용액의 농도, 계량 펌프를 통해 공급되는 방사 용액의 양, 얻고자 하는 나노섬유의 굵기 등을 고려하여 다양하게 적용할 수 있다.There is no restriction | limiting in particular in the electrospinning apparatus used by this invention. As shown in FIG. 2, an electrospinning apparatus using multiple nozzles may be used, and other types of electrospinning apparatuses may also be used. The electrospinning apparatus comprises a spinning unit consisting of a metering pump (2) and a plurality of nozzles (3) for supplying a polymer spinning solution, a high voltage generating unit by the high voltage generator (6) and a collector for fixing the nanofibers that are spun and volatilized It consists of (4). Generation voltage for spinning the nanofibers of the present invention can be variously applied in consideration of the concentration of the spinning solution, the amount of spinning solution supplied through the metering pump, the thickness of the nanofibers to be obtained, such as thousands to hundreds of thousands of volts .
다음으로는, 상기와 같은 전기방사 방식으로 제조된 수용성 고분자 나노섬유 부직포(A)를 100~180℃에서 열처리 한다.Next, the water-soluble polymer nanofiber nonwoven fabric (A) prepared by the electrospinning method as described above is heat-treated at 100 ~ 180 ℃.
상기 열처리 공정은 상기의 나노섬유 부직포(A)를 구성하는 나노섬유 내에 포함된 수용성 고분자 입자의 응집을 유도하기 위해 실시된다.The heat treatment process is performed to induce aggregation of the water-soluble polymer particles contained in the nanofibers constituting the nanofiber nonwoven fabric (A).
열처리 온도가 100℃ 미만일 경우에는 나노섬유 내 수용성 고분자 입자의 응집이 잘안되고, 180℃를 초과할 때에는 나노섬유내 폴리비닐알코올이 결정화되어 이후에 실시되는 폴리비닐알코올 제거공정에서 폴리비닐알코올이 잘 제거되지 않는 문제가 발생될 수 있다.When the heat treatment temperature is less than 100 ° C, aggregation of the water-soluble polymer particles in the nanofibers is poor. When the heat treatment temperature is higher than 180 ° C, the polyvinyl alcohol in the nanofibers is crystallized, and the polyvinyl alcohol is well removed in the subsequent polyvinyl alcohol removal process. Problems that cannot be eliminated can arise.
다음으로는, 상기와 같이 열처리된 나노섬유 부직포(A)를 물에 1시간 이상 침지시켜 나노섬유 내 폴리비닐알코올을 제거하여 본 발명에 따른 백혈구 제거용 필터를 제조한다.Next, the nanofiber nonwoven fabric (A) heat-treated as described above is immersed in water for 1 hour or more to remove polyvinyl alcohol in the nanofibers to prepare a leukocyte removal filter according to the present invention.
본 발명은 전기방사시 유기용매 대신에 물을 사용하기 때문에 수혈 중 혈액이 유기용매에 의해 오염되는 것을 방지할 수 있어서 혈액 안전성이 우수하고 친환 경적인 장점을 갖는다.Since the present invention uses water instead of the organic solvent during electrospinning, blood can be prevented from being contaminated by the organic solvent during blood transfusion, thereby providing excellent blood safety and environmentally friendly advantages.
또한, 본 발명은 평균직경이 100~2,000㎚인 나노섬유들로 구성되고, 공극의 평균직경이 0.5~3㎛인 나노섬유 부직포를 포함하기 때문에 백혈구 제거 효율과 적혈구 회수효율이 우수하다.In addition, the present invention is composed of nanofibers having an average diameter of 100 ~ 2,000nm, and comprises a nanofiber nonwoven fabric having a mean diameter of 0.5 ~ 3㎛ excellent white blood cell removal efficiency and red blood cell recovery efficiency.
본 발명에 따른 백혈구 제거용 필터(A)를 제조하는 방법 중 일례를 살펴보면, 앞에서 설명한 통상의 합성섬유 상에 접착제를 도포 또는 스프레이(Spray)한 다음 앞에서 설명한 전기방사 방식으로 제조한 나노섬유 부직포(A)를 접착제가 도포 또는 스프레이된 상기 합성섬유 부직포(B,C) 위에 겹쳐지게 올려준 다음, 이들을 열로울러 등으로 가열, 압착하여 필터를 제조할 수 있다.Looking at one example of the method for producing a leukocyte removal filter (A) according to the present invention, the nanofiber nonwoven fabric prepared by the electrospinning method after applying or spraying the adhesive on the conventional synthetic fibers described above ( A) is placed on the synthetic fiber nonwoven fabrics (B, C) coated or sprayed with an adhesive, and then heated and compressed with a heat roller or the like to prepare a filter.
본 발명에 따른 백혈구 제거용 필터는 ASTM F 2149-01 방법으로 측정한 백혈구 제거율과 적혈구 회수율이 각각 90% 이상과 85% 이상이고, ASTM F 756 방법으로 측정한 용혈율(적혈구 파괴율)이 10% 이하이고, 아래방법으로 측정한 흡수높이가 2~10㎝ 이다.The leukocyte removal filter according to the present invention has a leukocyte removal rate and an erythrocyte recovery rate of 90% or more and 85% or more, respectively, measured by ASTM F 2149-01 method, and a hemolysis rate (erythrocyte destruction rate) of 10% or more, measured by ASTM F 756 method. It is% or less and the absorption height measured by the following method is 2-10 cm.
흡수높이 측정방법Absorption Height Measurement Method
길이가 10㎝이고 폭이 1㎝인 필터(샘플)를 25℃물에 1㎝ 깊이로 담근 후 물의 흡수높이가 최대가 될 때까지 방치하여 상기의 최대 흡수높이를 흡수높이로 한다. 흡수높이를 육안으로 쉽게 확인할 수 있도록 물에 색소를 첨가하는 것이 바람직하다.After dipping a filter (sample) having a length of 10 cm and a width of 1 cm in a depth of 1 cm in water at 25 ° C., it is allowed to stand until the maximum absorption height of water is set to the maximum absorption height. It is desirable to add a pigment to the water so that the absorption height can be easily identified with the naked eye.
이하, 실시예를 통하여 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail through examples.
그러나, 하기 실시예는 본 발명의 일례를 나타내는 것으로서, 본 발명의 보호범위가 하기 실시예로만 한정되는 것은 아니다.However, the following examples show one example of the present invention, and the protection scope of the present invention is not limited only to the following examples.
실시예Example 1 One
수분산성 폴리우레탄 수지(수분산성 폴리머)를 90℃ 가열된 증류수에 15%(w/w)의 농도로 분산시킨 후, 여기에 검화도가 80%인 폴리비닐알코올 수지를 20%(w/w)의 농도로 용해시켜 방사용액을 제조하였다.After dispersing the water-dispersible polyurethane resin (water dispersible polymer) in distilled water heated to 90 ° C. at a concentration of 15% (w / w), 20% (w / w) of polyvinyl alcohol resin having a saponification degree of 80% It was dissolved at the concentration of) to prepare a spinning solution.
상기 방사용액을 도 2에 도시된 전기방사장치의 계량펌프(2)를 통해 28,000볼트(V)의 전압이 걸려있는 노즐(3)을 통해 28,000볼트(V)의 전압이 걸려있는 컬렉터(4) 상에 전기방사하여 평균직경이 600㎚인 나노섬유들이 5㎛의 두께로 적층되어 있고, 평균 공극크기가 3㎛인 나노섬유 부직포를 제조한 다음, 제조된 나노섬유 부직포를 140℃의 열풍으로 1시간 동안 열처리한 후, 계속해서 열처리된 나노섬유 부직포를 상온의 물에 3시간 동안 침지시켜 나노섬유 내에 포함된 폴리비닐알코올을 제거하여 수분산성 폴리우레탄 수지의 나노섬유 부직포를 제조하였다.Collector 4, the voltage of 28,000 volts (V) through the
다음으로, 상기 수분산성 폴리우레탄 나노섬유 부직포(A) 위에 평균직경이 3㎛인 폴리에스테르 필라멘트들로 구성되고 공극의 평균직경이 40㎛인 폴리에스테르 멜트브로윈 부직포(B)를 접착하였다.Next, a polyester melt blown nonwoven fabric (B) composed of polyester filaments having an average diameter of 3 μm and having an average diameter of pores of 40 μm was adhered on the water-dispersible polyurethane nanofiber nonwoven fabric (A).
다음으로, 상기 폴리에스테르 멜트브로운 부직포(C) 위에 평균직경이 20㎛인 폴리에스테르 필라멘트들로 구성되고 공극의 평균직경이 350㎛인 폴리에스테르 스펀본드 부직포(C)를 접착하여 3층 구조의 백혈구 제거용 필터를 제조하였다. Next, a polyester spunbond nonwoven fabric (C) having an average diameter of 350 μm and a pore diameter of 350 μm was bonded on the polyester melt blown nonwoven fabric (C) to form a three-layer structure. A leukocyte removal filter was prepared.
제조된 백혈구 제거용 필터의 각종 물성을 평가한 결과는 표 2와 같았다.The results of evaluating various physical properties of the prepared leukocyte removal filter were shown in Table 2.
실시예Example 2 ~ 2 to 실시예Example 3 및 3 and 비교실시예Comparative Example 1 One
수분산성 폴리머의 종류, 수분산성 폴리머 나노섬유 부직포(A)를 구성하는 나노섬유의 평균직경과, 수분산성 폴리머 나노섬유 부직포(A) 내 공극의 평균직경과, 수분산성 폴리머 나노섬유 부직포의 두께와, 열처리온도를 하기 표 1과 같이 변경한 것을 제외하고는 실시예 1과 동일하게 3층 구조인 백혈구 제거용 필터를 제조하였다.Type of water dispersible polymer, average diameter of nanofibers constituting water dispersible polymer nanofiber nonwoven fabric (A), average diameter of voids in water dispersible polymer nanofiber nonwoven fabric (A), thickness of water dispersible polymer nanofiber nonwoven fabric , Except that the heat treatment temperature was changed as shown in Table 1 was prepared in the same manner as in Example 1 leukocyte removal filter having a three-layer structure.
제조된 백혈구 제거용 필터의 각종 물성을 평가한 결과는 표 2와 같았다.The results of evaluating various physical properties of the prepared leukocyte removal filter were shown in Table 2.
비교실시예Comparative Example 1 One
상대점도가 2.5인 폴리아미드 수지를 개미산 수용액에 20%(w/w) 농도로 용해시킨 방사용액을 제조하였다.A spinning solution was prepared in which a polyamide resin having a relative viscosity of 2.5 was dissolved in a formic acid aqueous solution at a concentration of 20% (w / w).
상기 방사용액을 도 2에 도시된 전기방사장치의 계량펌프(2)를 통해 28,000볼트(V)의 전압이 걸려있는 노즐(3)을 통해 28,000볼트(V)의 전압이 걸려있는 컬렉터(4) 상에 전기방사하여 평균직경이 600㎚인 나노섬유들이 5㎛의 두께로 적층되어 있고, 평균 공극크기가 3㎛인 나노섬유 부직포를 제조하였다.Collector 4, the voltage of 28,000 volts (V) through the
다음으로 상기의 폴리아미드 나노섬유 부직포(A) 위에 평균직경이 3㎛인 폴리에스테르 필라멘트들로 구성되고 공극의 평균직경이 40㎛인 폴리에스테르 멜트브로윈 부직포(B)를 접착하였다.Next, on the polyamide nanofiber nonwoven fabric (A), a polyester melt blown nonwoven fabric (B) composed of polyester filaments having an average diameter of 3 μm and having an average diameter of pores of 40 μm was adhered.
다음으로, 상기 폴리에스테르 멜트브로운 부직포(C) 위에 평균직경이 20㎛인 폴리에스테르 필라멘트들로 구성되고 공극의 평균직경이 350㎛인 폴리에스테르 스펀본드 부직포(C)를 접착하여 3층 구조의 백혈구 제거용 필터를 제조하였다. Next, a polyester spunbond nonwoven fabric (C) having an average diameter of 350 μm and a pore diameter of 350 μm was bonded on the polyester melt blown nonwoven fabric (C) to form a three-layer structure. A leukocyte removal filter was prepared.
제조된 백혈구 제거용 필터의 각종 물성을 평가한 결과는 표 2와 같았다.The results of evaluating various physical properties of the prepared leukocyte removal filter were shown in Table 2.
도 1은 본 발명에 따른 백혈구 제거용 필터 일례의 단면 모식도.1 is a schematic cross-sectional view of an example of a leukocyte removal filter according to the present invention.
도 2는 본 발명에 포함된 수용성 폴리머 나노섬유 부직포(A)을 전기방사 방식으로 제조하는 공정 개략도.Figure 2 is a process schematic diagram of producing a water-soluble polymer nanofiber nonwoven fabric (A) included in the present invention by an electrospinning method.
도 3은 본 발명에 포함된 수용성 폴리머 나노섬유 부직포(A) 표면의 전자현미경 사진.Figure 3 is an electron micrograph of the surface of the water-soluble polymer nanofiber nonwoven fabric (A) included in the present invention.
* 도면 중 주요부분에 대한 부호설명* Code description for main parts of the drawings
A : 수용성 폴리머 나노섬유 부직포 B,C : 합성섬유 부직포A: Water-soluble polymer nanofiber nonwoven fabric B, C: Synthetic fiber nonwoven fabric
1 : 방사액 주탱크 2 : 계량펌프1: spinning liquid main tank 2: metering pump
3 : 노즐 4 : 컬렉터3: nozzle 4: collector
5 : 전압전달로드 6 : 전압발생장치5: voltage transfer rod 6: voltage generator
Claims (12)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080081776A KR101452251B1 (en) | 2008-08-21 | 2008-08-21 | Filter for removing a white corpuscle and method of manufacturing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080081776A KR101452251B1 (en) | 2008-08-21 | 2008-08-21 | Filter for removing a white corpuscle and method of manufacturing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20100023155A true KR20100023155A (en) | 2010-03-04 |
| KR101452251B1 KR101452251B1 (en) | 2014-10-23 |
Family
ID=42175440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020080081776A Expired - Fee Related KR101452251B1 (en) | 2008-08-21 | 2008-08-21 | Filter for removing a white corpuscle and method of manufacturing the same |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR101452251B1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101397063B1 (en) * | 2012-06-25 | 2014-05-21 | 충남대학교산학협력단 | Composite non-woven fabrics, manufacturing method thereof and backing film for patch of drug delivery using the same |
| KR101462513B1 (en) * | 2013-03-04 | 2014-11-19 | 주식회사 퓨어멤 | Multi-layer Filter for Removing Leukocytes and Preparation Method thereof |
| CN105597427A (en) * | 2015-12-22 | 2016-05-25 | 苏州协泰科技有限公司 | Manufacturing method of non-woven filter felt |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101810830B1 (en) | 2015-08-13 | 2017-12-20 | 주식회사 아모그린텍 | Portable pouch for water purifying |
| US10695486B2 (en) | 2015-10-14 | 2020-06-30 | Amogreentech Co., Ltd. | Liquid drug-filtering filter medium and filter module |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3172542B2 (en) * | 1990-06-25 | 2001-06-04 | テルモ株式会社 | Filter material for capturing leukocytes and method for producing the same |
-
2008
- 2008-08-21 KR KR1020080081776A patent/KR101452251B1/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101397063B1 (en) * | 2012-06-25 | 2014-05-21 | 충남대학교산학협력단 | Composite non-woven fabrics, manufacturing method thereof and backing film for patch of drug delivery using the same |
| KR101462513B1 (en) * | 2013-03-04 | 2014-11-19 | 주식회사 퓨어멤 | Multi-layer Filter for Removing Leukocytes and Preparation Method thereof |
| CN105597427A (en) * | 2015-12-22 | 2016-05-25 | 苏州协泰科技有限公司 | Manufacturing method of non-woven filter felt |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101452251B1 (en) | 2014-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100928232B1 (en) | Dust, deodorant and antibacterial filters with nanofiber webs | |
| Guibo et al. | The electrospun polyamide 6 nanofiber membranes used as high efficiency filter materials: Filtration potential, thermal treatment, and their continuous production | |
| KR101074359B1 (en) | Filter media of facial mask | |
| KR20100035208A (en) | Filter media and method of manufacturing the same | |
| KR101386424B1 (en) | Filter for removing a white corpuscle and method of manufacturing the same | |
| KR20100023155A (en) | Filter for removing a white corpuscle and method of manufacturing the same | |
| US11364470B2 (en) | Filter medium, manufacturing method therefor, and filter unit comprising same | |
| KR20090128108A (en) | Filter material for injection liquid filtration and syringe comprising the same | |
| KR20120110468A (en) | Method for manufacturing non-woven fabric composed of polyamide nanofiber with excellent water repellency and oil repellency | |
| KR101716598B1 (en) | Spinning nozzle, process for producing fibrous mass, fibrous mass, and paper | |
| KR102563110B1 (en) | Nanofiber filter and preparation method thereof | |
| KR101118081B1 (en) | Method of manufacturing nanofiber web | |
| WO2019058292A1 (en) | Nano-fiber based filter media and methods of preparation thereof | |
| KR101386391B1 (en) | Filter for removing a white corpuscle and method of manufacturing the same | |
| KR20100019169A (en) | Method of manufacturing nanofiber web | |
| KR101118079B1 (en) | Method of manufacturing nanofiber web | |
| KR102202190B1 (en) | Micro fiber including ferroelectric nanopowder | |
| KR101127947B1 (en) | Mask | |
| KR20100004141A (en) | Dustproof mask | |
| Zhu et al. | Textile applications of nanofibers | |
| KR20100078811A (en) | Electrospinning device | |
| KR20100003817A (en) | Dustproof mask | |
| KR20210152690A (en) | High Heat Resistant Multilayer Filter Media | |
| KR20100004189A (en) | Dust mask | |
| KR20120077244A (en) | Nozzle block for electrospinning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
St.27 status event code: A-0-1-A10-A12-nap-PA0109 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| R19-X000 | Request for party data change rejected |
St.27 status event code: A-3-3-R10-R19-oth-X000 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| R19-X000 | Request for party data change rejected |
St.27 status event code: A-3-3-R10-R19-oth-X000 |
|
| N231 | Notification of change of applicant | ||
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| R17-X000 | Change to representative recorded |
St.27 status event code: A-3-3-R10-R17-oth-X000 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| A201 | Request for examination | ||
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| D13-X000 | Search requested |
St.27 status event code: A-1-2-D10-D13-srh-X000 |
|
| D14-X000 | Search report completed |
St.27 status event code: A-1-2-D10-D14-srh-X000 |
|
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E90F | Notification of reason for final refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U11-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-5-5-R10-R13-asn-PN2301 St.27 status event code: A-5-5-R10-R11-asn-PN2301 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| FPAY | Annual fee payment |
Payment date: 20181001 Year of fee payment: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-5-5-R10-R13-asn-PN2301 St.27 status event code: A-5-5-R10-R11-asn-PN2301 |
|
| FPAY | Annual fee payment |
Payment date: 20191007 Year of fee payment: 6 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20201014 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20201014 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |