KR20140048067A - 자기-조립형 단백질의 고 농축 용액의 제조 방법 - Google Patents

자기-조립형 단백질의 고 농축 용액의 제조 방법 Download PDF

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Publication number: KR20140048067A
Authority: KR; South Korea
Prior art keywords: gly; ala ala; protein; ser; ggt
Prior art date: 2010-08-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

KR1020137007474A

Other languages

English (en)

Korean (ko)

Inventor

에프귀니 클리모프

부르그하르트 리브만

토마스 수브코브스키

마르틴 묄러

도리스 클리

아르템 다피덴코

비엡케 슈미츠

군터 솨르펜베르거

Original Assignee

바스프 에스이

칼 프로이덴베르그 카게

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-26

Filing date

2011-08-25

Publication date

2014-04-23

2011-08-25 Application filed by 바스프 에스이, 칼 프로이덴베르그 카게 filed Critical 바스프 에스이

2014-04-23 Publication of KR20140048067A publication Critical patent/KR20140048067A/ko

Status Withdrawn legal-status Critical Current

Links

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229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
FDRCDNZGSXJAFP-UHFFFAOYSA-M sodium chloroacetate Chemical compound [Na+].[O-]C(=O)CCl FDRCDNZGSXJAFP-UHFFFAOYSA-M 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
229920003048 styrene butadiene rubber Polymers 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960002663 thioctic acid Drugs 0.000 description 1
150000003567 thiocyanates Chemical class 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
235000015149 toffees Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000009261 transgenic effect Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
150000003673 urethanes Chemical class 0.000 description 1
230000002792 vascular Effects 0.000 description 1
229960000834 vinyl ether Drugs 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
238000005303 weighing Methods 0.000 description 1
150000003751 zinc Chemical class 0.000 description 1
239000004711 α-olefin Substances 0.000 description 1

Images

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
- D01D5/0007—Electro-spinning
- D01D5/0015—Electro-spinning characterised by the initial state of the material
- D01D5/0053—Electro-spinning characterised by the initial state of the material the material being a low molecular weight compound or an oligomer, and the fibres being formed by self-assembly
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/15—Proteins or derivatives thereof

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Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Textile Engineering (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Insects & Arthropods (AREA)
Polymers & Plastics (AREA)
Analytical Chemistry (AREA)
Materials Engineering (AREA)
Wood Science & Technology (AREA)
Mechanical Engineering (AREA)
Tropical Medicine & Parasitology (AREA)
Manufacturing & Machinery (AREA)
Peptides Or Proteins (AREA)
Materials For Medical Uses (AREA)
Artificial Filaments (AREA)
Nonwoven Fabrics (AREA)

KR1020137007474A 2010-08-26 2011-08-25 자기-조립형 단백질의 고 농축 용액의 제조 방법 Withdrawn KR20140048067A (ko)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP10174080		2010-08-26
EP10174080.1		2010-08-26
PCT/EP2011/064603 WO2012025582A2 (de)	2010-08-26	2011-08-25	Verfahren zur herstellung hochkonzentrierter lösungen von selbstassemblierenden proteinen

Publications (1)

Publication Number	Publication Date
KR20140048067A true KR20140048067A (ko)	2014-04-23

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Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020137007474A Withdrawn KR20140048067A (ko)	2010-08-26	2011-08-25	자기-조립형 단백질의 고 농축 용액의 제조 방법

Country Status (5)

Country	Link
EP (1)	EP2609109A2 (de)
JP (1)	JP2013544754A (de)
KR (1)	KR20140048067A (de)
CN (1)	CN103209991A (de)
WO (1)	WO2012025582A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR094432A1 (es)	2012-04-05	2015-08-05	Basf Plant Science Co Gmbh	Plantas resistentes a hongos que expresan hidrofobina
US9757330B2 (en)	2013-10-18	2017-09-12	Industrial Technology Research Institute	Recipe for in-situ gel, and implant, drug delivery system formed thereby
US10202636B2 (en) *	2013-12-24	2019-02-12	General Electric Company	Electrospun fibers for protein stabilization and storage
JP6460675B2 (ja) *	2014-08-04	2019-01-30	国立大学法人信州大学	シルク複合ナノファイバーの製造方法
GB201415681D0 (en)	2014-09-04	2014-10-22	Cambridge Entpr Ltd And President And Fellows Of Harvard College	Protien Capsules
CN105951210B (zh) *	2016-06-24	2018-06-19	南通纺织丝绸产业技术研究院	一种珠粒形貌的串珠纤维材料及其制备方法
CN107236999A (zh) *	2017-07-17	2017-10-10	合肥威斯伏新材料有限公司	一种鱼皮胶原自组装成纤维的方法
WO2019194249A1 (ja) *	2018-04-03	2019-10-10	Ｓｐｉｂｅｒ株式会社	ドープ液、改変フィブロイン繊維及びその製造方法
CN109137102B (zh) *	2018-09-30	2020-11-24	吉林大学	一种具有定向疏水的仿蜘蛛丝纤维结构制备方法
US12220445B2 (en)	2020-03-09	2025-02-11	Amprion, Inc.	Inert matrices for qualitative and semi-quantitative seed amplification assays
WO2021183469A1 (en) *	2020-03-09	2021-09-16	Amprion, Inc.	Cerebrospinal fluid assay control solution
CN113106756A (zh) *	2021-03-10	2021-07-13	浙江凯喜雅国际股份有限公司	一种蚕丝蛋白涂层液及其在纤维或织物表面改性中的应用
CN113508863B (zh) *	2021-07-14	2023-04-14	江南大学	一种全溶性食用菌蛋白及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE374905A (de) *	1929-12-23
JPS6170075A (ja) *	1984-09-12	1986-04-10	水島　繁三郎	形状記憶生糸の製造方法
DE4440858A1 (de)	1994-11-15	1996-05-23	Basf Ag	Biologisch abbaubare Polymere, Verfahren zu deren Herstellung sowie deren Verwendung zur Herstellung bioabbaubarer Formkörper
WO2003060099A2 (en)	2002-01-11	2003-07-24	Nexia Biotechnologies, Inc.	Methods and apparatus for spinning spider silk protein
EP1613796B1 (de) *	2003-04-10	2017-03-22	Tufts University	Konzentrierte wässrige seidenfibroinlösung und deren verwendung
CN104856962A (zh)	2006-01-20	2015-08-26	慕尼黑工业大学	两性自组装蛋白质在配制低水溶性的有效物质中的用途
CA2690658C (en) *	2007-06-20	2016-08-09	Basf Se	Synthetic repetitive proteins, their production and use thereof
JP2011530491A (ja)	2008-08-08	2011-12-22	ビーエーエスエフソシエタス・ヨーロピア	バイオポリマーに基づいた活性物質含有連続繊維層、その使用、およびその生産のための方法
CN102176905A (zh)	2008-08-08	2011-09-07	巴斯夫欧洲公司	具有受控释放的活性成分的含活性成分的纤维层状结构，其用途及其生产方法
DE102009040068A1 (de) *	2008-11-24	2010-05-27	Byk-Chemie Gmbh	Zusammensetzungen umfassend Glycidylether-Copolymere

2011
- 2011-08-25 WO PCT/EP2011/064603 patent/WO2012025582A2/de not_active Ceased
- 2011-08-25 JP JP2013525306A patent/JP2013544754A/ja not_active Withdrawn
- 2011-08-25 EP EP11752173.2A patent/EP2609109A2/de not_active Withdrawn
- 2011-08-25 CN CN201180051094XA patent/CN103209991A/zh active Pending
- 2011-08-25 KR KR1020137007474A patent/KR20140048067A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
JP2013544754A (ja)	2013-12-19
EP2609109A2 (de)	2013-07-03
WO2012025582A3 (de)	2012-09-07
WO2012025582A2 (de)	2012-03-01
CN103209991A (zh)	2013-07-17

Legal Events

Date	Code	Title	Description
2013-03-25	PA0105	International application	Patent event date: 20130325 Patent event code: PA01051R01D Comment text: International Patent Application
2014-04-23	PG1501	Laying open of application
2016-09-26	PC1203	Withdrawal of no request for examination
2016-09-26	WITN	Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid

Publication	Publication Date	Title
KR20140048067A (ko)	2014-04-23	자기-조립형 단백질의 고 농축 용액의 제조 방법
US20140194025A1 (en)	2014-07-10	Production of Highly Concentrated Solutions of Self-Assembling Proteins
Wang et al.	2020	Incorporation of metal-organic frameworks into electrospun chitosan/poly (vinyl alcohol) nanofibrous membrane with enhanced antibacterial activity for wound dressing application
Hardy et al.	2009	Silk-inspired polymers and proteins
Onder et al.	2022	Self-assembled silk fibroin hydrogels: From preparation to biomedical applications
Doblhofer et al.	2015	To spin or not to spin: spider silk fibers and more
Wang et al.	2021	Characterization of undegraded and degraded silk fibroin and its significant impact on the properties of the resulting silk biomaterials
You et al.	2017	Regenerated egg white/silk fibroin composite films for biomedical applications
Zhang et al.	2020	A facile and large-scale synthesis of a PVA/chitosan/collagen hydrogel for wound healing
Debabov et al.	2020	Recombinant spidroins as the basis for new materials
JP2011208286A (ja)	2011-10-20	シルク複合ナノファイバー及びその製造方法
Kar et al.	2013	Silk gland fibroin from indian muga silkworm Antheraea assama as potential biomaterial
Tsuchiya et al.	2017	Tensile reinforcement of silk films by the addition of telechelic-type polyalanine
CN106397545A (zh)	2017-02-15	一种水凝胶材料及其制备方法和应用
CN106750262A (zh)	2017-05-31	两亲性嵌段抗菌肽的合成及其组装体的制备方法和应用
JP5453690B2 (ja)	2014-03-26	コラーゲン・キトサン複合繊維状多孔体及びその製造方法
Herold et al.	2017	Applicability of biotechnologically produced insect silks
CN108691028B (zh)	2019-07-23	一种聚乳酸/大豆分离蛋白复合纳米纤维的制备方法和得到的纳米纤维及应用
Qu et al.	2021	Study on the effect of stretching on the strength of natural silk based on different feeding methods
CN113214359A (zh)	2021-08-06	一种多肽化合物、多肽自组装网络材料及其制备方法与应用
CN117144684A (zh)	2023-12-01	一种改性壳聚糖基纳米纤维疏水性抗菌材料及制备和应用
Wang et al.	2024	Meso-reconstructed silk fibroin/iron oxide nanoparticle composites dominated by silk I structures through unidirectional nanopore dehydration for potential application in bone regeneration
Peng et al.	2022	High-strength collagen-based composite films regulated by water-soluble recombinant spider silk proteins and water annealing
R Karim et al.	2016	Conducting and biopolymer based electrospun nanofiber membranes for wound healing applications
Xie et al.	2017	Preparation of a novel silk microfiber covered by AgCl nanoparticles with antimicrobial activity