KR20150108945A - 유인원 ｅ 아데노바이러스 ｓａｄｖ-39, -25.2, -26, -30, -37, 및 -38 - Google Patents

유인원 ｅ 아데노바이러스 ｓａｄｖ-39, -25.2, -26, -30, -37, 및 -38 Download PDF

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KR20150108945A
KR20150108945A KR1020157025105A KR20157025105A KR20150108945A KR 20150108945 A KR20150108945 A KR 20150108945A KR 1020157025105 A KR1020157025105 A KR 1020157025105A KR 20157025105 A KR20157025105 A KR 20157025105A KR 20150108945 A KR20150108945 A KR 20150108945A
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소우미트라 로이
제임스 엠. 윌슨
뤽 에이치. 반덴베르그
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더 트러스티스 오브 더 유니버시티 오브 펜실바니아
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Abstract

재조합 벡터는 조절 서열의 제어 하에서 유인원 아데노바이러스 SAdV-39, -25.2, -26, -30, -37, 및 -38 서열 및 이종성 유전자를 포함한다. 유인원 아데노바이러스 SAdV-39, -25.2, -26, -30, -37, 및 -383 유전자(들)를 발현시키는 셀 라인이 또한 개시된다. 벡터 및 셀 라인을 사용하는 방법이 제공된다.

Description

유인원 Ｅ 아데노바이러스 ＳＡＤＶ-39, -25.2, -26, -30, -37, 및 -38{SIMIAN E ADENOVIRUSES SADV-39, -25.2, -26, -30, -37, AND -38}
CD로 제출된 자료의 참고로써 포함
출원인은 본원에서 제공되는 CD의 서열목록 자료를 참고로써 포함한다. 이 CD는 2개로 공급되며 단지 컴퓨터로 판독가능한 형태로 "서열목록"을 함유한다. 이들 디스크를 각각 "카피 1" 및 "카피 2"의 라벨을 붙인다. 이들 디스크의 파일을 "UPN-U4623 PCT sequence listing.txt"의 라벨을 붙인다.
아데노바이러스는 약 36 킬로베이스(kb)의 게놈 크기를 가지는 이중-나선 DNA 바이러스이며, 이는 다양한 표적 조직에서 고성능 유전자 전이 및 거대 이식 유전자 수용력을 달성하는 그것의 능력에 기인하여 유전자 전달 용도를 위해 널리 사용되었다. 전통적으로 아데노바이러스의 E1 유전자는 결실되고, 선택 프로모터, 관심 유전자의 cDNA 서열 및 폴리 A 시그널로 구성되는 이식 유전자 카세트로 대체되는데, 이는 복제 결함 재조합 바이러스를 초래한다.
아데노바이러스는 3개의 주요 단백질, 헥손(II), 펜톤 염기(III) 및 혹모양 섬유(IV)와 다수의 다른 부수적 단백질, VI, VIII, IX, IIIa 및 IVa2로 구성되는 다면체형의 캡시드를 가지는 특징적인 형태를 가진다[W.C. Russell, J. Gen Virol., 81 :2573-2604 (2000년 11월)]. 바이러스 게놈은 역위 말단 반복(ITR)을 가지는 5' 말단에 공유적으로 부착되는 말단 단백질을 가지는 선형의, 이중-나선 DNA이다. 바이러스 DNA는 고염기성 단백질 VII 및 소펩티드 pX(이전에 뮤로 언급됨)와 상세하게 관련된다. 다른 단백질 V는 이 DNA-단백질 복합체와 함께 패키징되고 단백질 VI를 통해 캡시드에 구조적 연결을 제공한다. 바이러스는 또한 성숙한 감염 바이러스를 만들기 위해 일부 구조적 단백질을 처리하는데 필요한 바이러스-암호화된 프로테아제를 함유한다.
분류체계는 인간, 유인원, 소, 말, 돼지, 양, 개 및 주머니쥐 아데노바이러스를 포함하는 포유류아데노바이러스 과를 위해 개발되었다. 이 분류체계는 적혈구를 교착시키기 위해 과 내의 아데노바이러스 서열의 다른 능력에 기초하여 개발되었다. 결과는 현재 아군 A, B, C, D, E 및 F로서 언급되는 6개의 아군이었다. B.N Fields et al, (Lippincott Raven Publishers, Philadelphia, 1996)에 의해 편집된 FIELD'S VIROLOGY, 6th Ed.의 T. Shenk et al, Adenovihdae : The Viruses and their Replication", Ch. 67, p. 111-2112 참조.
재조합 아데노바이러스는 숙주 세포에 이종성 분자의 전달에 대해 설명되었다. 두 침팬지 아데노바이러스의 게놈을 설명하는 미국 특허 6,083,716 참조. 유인원 아데노바이러스, C5, C6 및 C7은 백신 벡터로서 유용한 미국 특허 7,247,472호에서 설명되었다. 다른 침팬지 아데노바이러스는 아데노바이러스 백신 담체를 제조하는데 유용한 WO 2005/1071093에서 설명되었다.
당업계에서 필요로 되는 것은 표적에 분자를 효과적으로 전달하고 모집단에서 선택된 아데노바이러스 항원형에 기존 면역의 효과를 최소화하는 벡터이다.
아과 E 내의 5개의 신규한 유인원 아데노바이러스의 분리된 핵산 서열 및 아미노산 서열 및 이들 서열을 함유하는 벡터가 본원에서 제공된다. 또한 본 발명의 벡터 및 세포를 사용하는 다수의 방법이 제공된다. 이들 아데노바이러스는 SAdV-39, SAdV-25.2, SAdV-26, SAdV-30, SAdV-37 및 SAdV-38를 포함한다.
본원에 기술되는 방법은 본 발명의 벡터를 투여함으로써 포유동물 환자에 하나 이상의 선택된 이종성 유전자(들)을 전달하는 단계를 수반한다. 백신접종을 위해 본원에서 기술되는 조성물의 사용은 보호성 면역 반응의 유발을 위한 선택된 항원의 제시를 허용한다. 이들 유인원 아데노바이러스에 기초한 벡터는 또한 시험관내 이종성 유전자 생성물을 만들기 위해 사용될 수 있다. 이러한 유전자 생성물은 그 자체가 본원에 기술되는 것과 같은 다양한 목적을 위해 유용하다.
본 발명의 이들 및 다른 구체예 및 이점은 하기에서 더욱 상세하게 기술된다.
모두 침팬지 배설물로부터 분리된 유인원 아데노바이러스 39, SAdV-25.2, SAdV-26, SAdV-30, SAdV-37 및 SAdV-38로부터의 신규 핵산 및 아미노산 서열이 제공된다.
또한 재조합 단백질 또는 단편 또는 다른 시약의 시험관 내 생성에서 사용을 위한 이들 벡터를 생성하기 위한 신규 아데노바이러스 벡터 및 팩키징 셀 라인이 제공된다. 더 나아가 치료적 또는 백신 목적을 위한 이종성 분자를 전달하는데 사용을 위한 조성물이 제공된다. 이러한 치료적 또는 백신 조성물은 삽입된 이종성 분자를 전달하는 아데노바이러스 벡터를 함유한다. 게다가, 신규의 SAdV 서열은 재조합 아데노-관련 바이러스(AAV) 벡터의 생성을 위해 필요로 되는 필수적인 헬퍼 기능을 제공하는데 유용하다. 따라서, 이러한 생성 방법에서 이들 서열을 사용하는 헬퍼 구조체, 방법 및 셀 라인이 제공된다.
핵산 또는 그것의 단편을 말할 때, 용어 "실질적인 상동성" 또는 "실질적인 유사성"은, 다른 핵산(또는 그것의 상보적 가닥)과 함께 적절한 뉴클레오티드 삽입 또는 결실에 의해 최상으로 배열될 때, 배열된 서열의 적어도 약 95 내지 99%로 뉴클레오티드 서열 동일성이 있음을 나타낸다.
아미노산 또는 그것의 단편을 말할 때, 용어 "실질적인 상동성" 또는 "실질적인 유사성"은, 다른 아미노산(또는 그것의 상보적 가닥)과 함께 적절한 아미노산 삽입 또는 결실에 의해 최상으로 배열될 때, 배열된 서열의 적어도 약 95 내지 99%로 아미노산 서열 동일성이 있음을 나타낸다. 바람직하게는, 상동성은 길이에 있어서 적어도 8개의 아미노산, 또는 더 바람직하게는 적어도 15개의 아미노산인 전장 서열, 또는 그것의 단백질, 또는 그것의 단편에 있다. 적절한 단편의 예는 본원에서 기술된다.
핵산 서열에 있어서 용어 "백분율 서열 동일성" 또는 "동일한"은 최대 대응에 대해 배열될 때 동일한 두 서열의 잔기를 말한다. 한 서열과 다른 서열을 배열하는데 갭이 필요로 될 때, 스코어링의 정도는 갭에 대한 불이익 없이 더 긴 서열에 대해 계산된다. 폴리뉴클레오티드 또는 암호화된 폴리펩티드의 기능성을 보존하는 서열은 이에 의해 더욱 밀접하게 동일하다. 서열 길이 동일성 비교는 게놈의 전장(예를 들어, 약 36 kbp), 유전자, 단백질, 서브유닛, 또는 효소의 오픈리딩프레임의 전장[예를 들어, 아데노바이러스 코딩 영역을 제공하는 표]에 걸쳐 있을 수 있고, 또는 적어도 약 500 내지 5000개의 뉴클레오티드의 단편이 요망된다. 그러나, 예를 들어, 적어도 약 9개의 뉴클레오티드, 보통 적어도 약 20 내지 24개의 뉴클레오티드, 적어도 약 28 내지 32개의 뉴클레오티드, 적어도 약 36개 또는 그 이상의 뉴클레오티드를 가지는 더 작은 단편들 사이의 동일성이 또한 요망될 수 있다. 유사하게, "백분율 서열 동일성"은 단백질, 또는 그것의 단편의 전장에 걸쳐서 아미노산 서열에 대해 용이하게 결정될 수 있다. 적절하게, 단편은 길이에 있어서 적어도 8개의 아미노산이며, 약 700개까지의 아미노산이 있을 수 있다. 적절한 단편의 예는 본원에서 기술된다.
동일성은 디폴트 세팅에서 정의되는 바와 같은 이러한 알고리즘 및 컴퓨터 프로그램을 사용하여 용이하게 결정된다. 바람직하게는, 이러한 동일성은 단백질, 효소, 서브유닛의 전장에 걸쳐, 또는 길이에 있어서 적어도 약 8개의 단편에 걸쳐서 있다. 그러나, 동일성은 더 짧은 영역에 기초할 수 있으며, 동일성 유전자 생성물이 배치되는 사용에 적합하다.
본원에서 기술되는 바와 같은, 배열은 인터넷의 웹 서버를 통해 접근가능한 "Clustal W"와 같은 다양한 일반 공중에게 또는 상업적으로 이용가능한 Multiple Sequence Alignment 프로그램을 사용하여 수행된다. 또 다르게는, 벡터 NTI® 유틸리티[InVitrogen]가 또한 사용된다. 상기 기술된 프로그램에 함유된 것들을 포함하는 뉴클레오티드 서열 동일성을 측정하는데 사용될 수 있는 당업계에 공지된 다수의 알고리즘이 있다. 다른 예에서, 폴리뉴클레오티드 서열은 Fasta, GCG Version 6.1의 프로그램을 사용하여 비교될 수 있다. Fasta는 질의와 검색 서열 사이의 최상의 중첩 영역의 배열 및 백분율 서열 동일성을 제공한다. 예를 들어, 핵산 서열 사이의 백분율 서열 동일성은 참고로써 본원에 포함되는 GCG Version 6.1에서 제공되는 바와 같은 Fasta와 그것의 디폴트 매개변수(워드 크기 6 및 스코어링 매트릭스에 대한 NOPAM 인자)를 사용하여 결정될 수 있다. 유사하게 프로그램은 아미노산 배열을 수행하기 위해 이용가능하다. 일반적으로, 당업자가 필요하다면 이들 세팅을 변경할 수 있지만, 이들 프로그램은 디폴트 세팅에서 사용된다. 또 다르게는, 당업자는 기준 알고리즘 및 프로그램에 의해 제공되는 동일성 또는 배열의 최소한의 수준을 제공하는 다른 알고리즘 또는 컴퓨터 프로그램을 이용할 수 있다.
폴리뉴클레오티드에 사용되는 "재조합"은, 폴리뉴클레오티드가 클로닝, 제한 또는 연결 단계, 및 천연에서 발견되는 폴리뉴클레오티드와 별개인 구조체를 초래하는 다른 과정의 다양한 조합의 생성물이라는 것을 의미한다. 재조합 바이러스는 재조합 폴리뉴클레오티드를 포함하는 바이러스 입자이다. 용어는 각각 본래의 폴리뉴클레오티드 구조체의 복제물 및 본래의 바이러스 구조체의 자손을 포함한다.
"이종성"은 비교되는 독립체의 나머지로부터 유전자형으로 완전한 독립체에서 유래됨을 의미한다. 예를 들어, 플라스미드에 유전공학 기술에 의해 도입된 폴리뉴클레오티드 또는 다른 종으로부터 유래된 벡터는 이종성 폴리뉴클레오티드이다. 원래의 코딩 서열로부터 제거되고 천연에서는 연결된 것으로 발견되지 않는 코딩 서열에 작동가능하게 연결된 프로모터는 이종성 프로모터이다. 바이러스 또는 바이러스 벡터의 게놈으로 클로닝된 자리-특이적 재조합 자리(바이러스의 게놈은 천연에서는 그것을 함유하지 않는다)는 이종성 재조합 자리이다. 재조합 효소에 대한 서열을 암호화하는 폴리뉴클레오티드가 재조합효소를 정상적으로 발현하지 않는 세포를 유전적으로 변경하기 위해 사용될 때, 폴리뉴클레오티드와 재조합효소는 둘 다 세포에 이종성이다.
본 명세서 및 청구항을 통해 사용되는, 용어 "포함하다" 및 그것의 변형인 "포함하는"은 다른 성분, 요소, 완전체, 단계 등에 포괄적이다. 용어 "구성된다" 또는 "구성되는"은 다른 성분, 구성요소, 정수, 단계 등에 배타적이다.
I. 유인원 아데노바이러스 서열
본 발명은 각각이 천연에서 연관된 다른 물질로부터 분리된 유인원 아데노바이러스 39 (SAdV-39), SAdV-25.2, -26, -30, -37 또는 -38의 핵산 서열 및 아미노산 서열을 제공한다.
A. 핵산 서열
본원에서 제공되는 SAdV-39 핵산 서열은 SEQ 1D NO: 1의 뉴클레오티드 1 내지 36553을 포함한다. 본원에서 제공되는 SAdV-25.2 핵산 서열은 SEQ ID NO: 130의 뉴클레오티드 1 내지 36629를 포함한다. 본원에 제공되는 SAdV-26 핵산 서열은 SEQ ID NO: 162의 뉴클레오티드 1 내지 36628을 포함한다. SAdV-30 핵산 서열은 SEQ ID NO: 98의 뉴클레오티드 1 내지 36621을 포함한다. 본원에 제공되는 SAdV-37 핵산 서열은 SEQ ID NO: 33의 뉴클레오티드 1 내지 36634를 포함한다. 본원에 제공되는 SAdV-38 핵산 서열은 SEQ ID NO: 65의 1 내지 36494을 포함한다.
본원에 참고로써 포함되는 서열목록을 참조. 한 구체예에서, 본 발명의 핵산 서열은 각각 SEQ ID NO: 1, 130, 162, 98, 130, 또는 65의 서열에 상보적인 가닥뿐만 아니라 하기 서열의 서열의 대응하는 RNA 및 cDNA 서열 및 그것의 상보적 가닥을 더 포함한다. 다른 구체예에서, 핵산 서열은 서열목록과 98.5% 이상 동일한, 바람직하게는 약 99% 동일한 서열을 더 포함한다. 또한 한 구체예에서, SEQ ID NO: 1, 130, 162, 98, 130, 또는 65 및 그것의 상보적 가닥에서 제공된 서열의 천연 변이체 및 공학적 변형이 포함된다. 이러한 변형은, 예를 들어, 당업계에 알려진 표지, 메틸화, 및 하나 이상의 자연적으로 발생하는 뉴클레오티드의 축퇴 뉴클레오티드로의 치환을 포함한다.
[표 1]
Figure pat00001
Figure pat00002
Figure pat00003
Figure pat00004
Figure pat00005
한 구체예에서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 서열의 단편, 및 그것의 상보적 가닥, 그것에 상보적인 cDNA 및 RNA가 제공된다. 적당한 단편은 길이에 있어 적어도 15개의 뉴클레오티드이며, 기능적 단편, 즉, 생물학적 관심이 있는 단편을 포함한다. 예를 들어, 기능적 단편은 요망되는 아데노바이러스 생성물을 발현시킬 수 있고 또는 재조합 바이러스 벡터의 생성에 유용할 수 있다. 이러한 단편은 유전자 서열 및 본원의 표에 열거되는 단편을 포함한다. 표는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열의 전사체 영역 및 오픈리딩 프레임을 제공한다. 특정 유전자에 대해, 전사체 및 오픈리딩프레임(ORF)은 SEQ ID NO: 1, 130, 162, 98, 130, 또는 65에서 존재하는 상보적인 가닥에 위치된다. 예를 들어, E2b, E4 및 E2a 참조. 암호화된 단백질의 계산된 분자량이 또한 나타난다. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 E1a 오픈리딩프레임 및 E2b 오픈리딩프레임은 내부 스플라이스 자리를 함유한다는 것에 주의한다. 이들 스플라이스 자리는 상기 표에서 기록된다.
SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스 핵산 서열은 치료제로서 및 다양한 벡터 시스템 및 숙주 세포의 구성에서 유용하다. 본원에서 사용되는, 벡터는 네이키드 DNA, 플라스미드, 바이러스, 코스미드 또는 에피솜을 포함하는 어떤 적당한 핵산 분자를 포함한다. 이들 서열 및 생성물은 단독으로 또는 다른 아데노바이러스 서열 또는 분획과 조합하여, 또는 다른 아데노바이러스 또는 비-아데노바이러스 서열로부터의 요소와 조합하여 사용될 수 있다. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열은 안티센스 전달 벡터, 유전자 치료 벡터, 또는 백신 벡터로서 또한 유용하다. 따라서, 추가로 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열을 함유하는 핵산 분자, 유전자 전달 벡터, 및 숙주 세포가 제공된다.
예를 들어, 본 발명은 본 발명의 유인원 Ad ITR 서열을 함유하는 핵산 분자를 포함한다. 다른 예에서, 본 발명은 원하는 Ad 유전자 생성물을 암호화하는 본 발명의 유인원 Ad 서열을 함유하는 핵산 분자를 제공한다. 본 발명의 서열을 사용하여 구성되는 또 다른 핵산 분자는 본원에 제공되는 정보의 관점에서 당업자에게 용이하게 명백할 것이다.
한 구체예에서, 본원에서 확인되는 유인원 Ad 유전자 영역은 세포에 이종성 분자의 전달을 위한 다양한 벡터에서 사용될 수 있다. 예를 들어, 벡터는 패키징 숙주 세포에서 바이러스 벡터를 발생시키는 목적을 위해 아데노바이러스 캡시드 단백질(또는 그것의 단편)의 발현에 대해 발생된다. 이러한 벡터는 트랜스 발현을 위해 설계될 수 있다. 또 다르게는, 이러한 벡터는 원하는 아데노바이러스 기능을 발현시키는 서열, 예를 들어, 하나 이상의 E1a, E1b, 말단 반복 서열, E2a, E2b, E4, E4ORF6 영역을 안정하게 함유하는 세포를 제공하기 위해 설계된다.
게다가, 아데노바이러스 유전자 서열 및 그것의 단편은 헬퍼-의존 바이러스(예를 들어, 필수 기능이 결핍된 아데노바이러스 벡터, 또는 아데노-관련 바이러스(AAV))의 생성에 필요한 헬퍼 기능을 제공하는데 유용하다. 이러한 생성 방법에 대해, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38서열은 인간 Ad에 기술된 것과 유사한 방법인 그러한 방법으로 이용될 수 있다. 그러나, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 사이의 서열, 서열과 인간 Ad의 그것들의 차이점 때문에, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열의 사용은 rAAV 생성 동안 감염성 아데노바이러스 오염물질을 생성할 수 있는 인간 Ad E1 기능을 전달하는 숙주 세포, 예를 들어, 293 세포에서 헬퍼 기능을 가지는 상동 재조합의 가능성을 크게 최소화하거나 제거한다.
아데노바이러스 헬퍼 기능을 사용하는 rAAV를 생성하는 방법은 인간 아데노바이러스 항원형과 함께 문헌에서 길이로 기술되었다. 예를 들어, 미국 특허 6,258,595 및 그것에 인용된 참고문헌을 참조. 또한, 미국 특허 5,871,982; WO 99/14354; WO 99/15685; WO 99/47691 참조. 이들 방법은 또한 비-인간 영장류 AAV 항원형을 포함하는 비-인간 항원형 AAV의 생성에 사용될 수 있다. 필요한 헬퍼 기능(예를 들어, E1a, E1b, E2a 및/또는 E4ORF6)을 제공하는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열은 필요한 아데노바이러스 기능을 제공하는데 특히 유용할 수 있는 한편, 어떤 다른 아데노바이러스와 재조합의 가능성을 최소화 또는 제거하는 것은 전형적으로 인간 기원의 rAAV-패키징 세포에서 존재한다. 따라서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 선택된 유전자 또는 오픈리딩프레임은 이들 rAAV 생성 방법에 사용될 수 있다.
또 다르게는, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 서열을 기초로 한 재조합 벡터는 이들 방법에 사용될 수 있다. 이러한 재조합 아데노바이러스 유인원 벡터는, 그것의 발현을 제어하는 조절 서열의 제어하에서 예를 들어, 침팬지 Ad 서열이 예를 들어, AAV 3' 및/또는 5' ITRs 및 이식 유전자로 구성되는 rAAV 발현 카세트 옆에 배치되는 하이브리드 침팬지 Ad/AAV를 포함할 수 있다. 당업자는 또 다른 유인원 아데노바이러스 벡터 및/또는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 유전자 서열이 아데노바이러스 헬퍼에 의존하여 rAAV 및 다른 바이러스의 생성에 유용할 것임을 인식할 것이다.
또 다른 구체예에서, 핵산 분자는 숙주 세포에서 선택된 아데노바이러스 유전자 생성물의 전달 및 발현을 위해 설계되어 원하는 생리적 효과를 이룬다. 예를 들어, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 E1a 단백질을 암호화하는 서열을 함유하는 핵산 분자는 암 치료제로서 사용을 위해 피험자에게 전달될 수 있다. 선택적으로, 이러한 분자는 지질-계 담체에서 제형화되고, 바람직하게는 암세포를 표적화한다. 이러한 제형은 다른 암 치료제(예를 들어, 시스플라틴, 탁솔 등)와 조합될 수 있다. 본원에 제공되는 아데노바이러스 서열에 대한 또 다른 사용은 당업자에게 용이하게 명백할 것이다.
게다가, 당업자는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열이 치료 및 면역 분자의 시험관 내, 생체 밖 또는 생체 내 전달을 위해 다양한 바이러스 및 비-바이러스 벡터 시스템에 대한 사용에 용이하게 적용될 수 있다는 것을 용이하게 이해할 것이다. 예를 들어, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 유인원 Ad 서열은 다양한 rAd 및 비-rAd 벡터 시스템에 이용될 수 있다. 이러한 벡터 시스템은, 예를 들어, 플라스미드, 렌티바이러스, 레트로바이러스, 수두바이러스, 우두 바이러스, 및 특히 아데노-연관 바이러스 시스템을 포함할 수 있다. 이러한 벡터 시스템의 선택은 본 발명의 제한이 아니다.
본 발명은 추가로 본 발명의 유인원 및 유인원-유래 단백질의 생성에 유용한 분자를 제공한다. 본 발명의 유인원 Ad DNA 서열을 포함하는 폴리뉴클레오티드를 전달하는 이러한 분자는 네이키드 DNA, 플라스미드, 바이러스 또는 다른 유전적 구성요소의 형태일 수 있다.
B. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스 단백질
본원에 기술되는 아데노바이러스 핵산에 의해 암호화되는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스의 유전자 생성물, 예컨대, 단백질, 효소 및 그것의 단편이 제공된다. 더 나아가, 다른 방법에 의해 발생되는 이들 핵산 서열에 의해 암호화된 아미노산 서열을 가지는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 단백질, 효소, 및 그것의 단편이 포함된다. 이러한 단백질은 상기 표에서 확인되는 오픈리딩프레임에 의해 암호화되는 것, 서열목록에서 제공되는 SEQ ID NO에 대한 하기 표에서 나타내는 단백질, 및 단백질 및 폴리펩티드의 단편을 포함한다.
Figure pat00006
Figure pat00007
따라서, 한 양태에서, 실질적으로 순수한, 즉, 다른 바이러스 및 단백질성 단백질이 없는 독특한 유인원 아데노바이러스 단백질이 제공된다. 바람직하게는, 이들 단백질은 적어도 10% 상동성, 더 바람직하게는 60% 상동성, 및 가장 바람직하게는 95% 상동성이다.
한 구체예에서, 독특한 유인원-유래 캡시드 단백질이 제공된다. 본원에서 사용된 바와 같은, 유인원-유래 캡시드 단백질은, 제한 없이, 키메라 캡시드 단백질, 융합 단백질, 인공 캡시드 단백질, 합성 캡시드 단백질, 및 재조합 캡시드 단백질을 포함하여, 이들 단백질의 의미에 대한 제한 없이, 상기 정의한 바와 같은 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 캡시드 단백질 또는 그것의 단편을 함유하는 어떤 아데노바이러스 캡시드 단백질을 포함한다.
적당하게, 이들 유인원-유래 캡시드 단백질은 다른 아데노바이러스 항원형의 캡시드 영역 또는 그것의 단편, 또는 본원에서 기술되는 바와 같은 변형된 유인원 캡시드 단백질 또는 단편과 조합하여 하나 이상의 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 영역 또는 그것의 단편(예를 들어, 헥손, 펜톤, 섬유 또는 그것의 단편)을 함유한다. 본원에서 사용되는 바와 같은 "변형된 굴성과 연관된 캡시드 단백질의 변형"은 변경된 캡시드 단백질, 즉, 펜톤, 헥손 또는 섬유 단백질 영역, 또는 그것의 단편, 예로써, 섬유 영역의 혹(knob) 도메인, 또는 이를 암호화하는 폴리뉴클레오티드를 포함하는데, 특이성은 변경된다. 유인원-유래 캡시드는 인간 또는 비-인간 기원일 수 있는 하나 이상의 본 발명 또는 다른 Ad 항원형과 함께 구성될 수 있다. 이러한 Ad는 ATCC, 상업적 및 학업적 공급원을 포함하는 다양한 공급원으로부터 획득될 수 있고, 또는 Ad의 서열은 GenBank 또는 다른 적당한 공급원으로부터 획득될 수 있다.
SAdV-39 [SEQ ID NO: 6], SAdV-25.2 [SEQ ID NO: 135], -26 [SEQ ID NO: 167], -30 [SEQ ID NO: 103], -37 [SEQ ID NO: 38] 또는 -38 [SEQ ID NO: 70]의 펜톤 단백질의 아미노산 서열이 제공된다. 적절하게는, 이들 펜톤 단백질, 또는 그것의 독특한 단편은 다양한 목적을 위해 이용될 수 있다. 적절한 단편의 예는 각각 상기 제공된 아미노산 넘버링 및 각각 SEQ ID NO:6, 103, 135, 38, 70, 167 또는 70에 기초한 약 50, 100, 150, 또는 200개의 아미노산의 N-말단 및/또는 C-말단의 절단(truncation)을 가지는 펜톤을 포함한다. 다른 적당한 단편은 더 짧은 내부의, C-말단의 또는 N-말단의 단편을 포함한다. 추가로, 펜톤 단백질은 당업자에게 공지된 다양한 목적을 위해 변형될 수 있다.
또한 SAdV-39[SEQ ID NO: 11], SAdV-25.2 [SEQ ID NO: 140], -26 [SEQ ID NO: 172], -30 [SEQ ID NO: 108], -37 [SEQ ID NO: 43] 또는 -38 [SEQ ID NO: 75]의 헥손 단백질의 아미노산 서열이 제공된다. 적절하게는, 이들 헥손 단백질, 또는 그것의 독특한 단편은 다양한 목적을 위해 이용될 수 있다. 적절한 단편의 예는 상기 제공된 아미노산 넘버링 및 각각 SEQ ID NO: 11, 140, 172, 108, 43, 또는 75에 기초한 약 50, 100, 150, 200, 300, 400, 또는 500개의 아미노산의 N-말단 및/또는 C-말단의 절단을 가지는 헥손을 포함한다. 다른 적당한 단편은 더 짧은 내부의, C-말단, 또는 N-말단의 단편을 포함한다. 예를 들어, 한 적당한 단편은 헥손 단백질, 지정된 DE1 및 FG1, 또는 그것의 고도가변 영역의 루프 영역(도메인)이다. 이러한 단편은 각각 SEQ ID NO: 11, 140, 172, 108, 43 또는 75에 대하여 유인원 헥손 단백질의 아미노산 잔기 약 125 내지 443; 약 138 내지 441, 또는 더 적은 단편을 걸치는 영역, 예로써, 약 잔기 138 내지 잔기 163; 약 170 내지 약 176; 약 195 내지 약 203; 약 233 내지 약 246; 약 253 내지 약 374; 약 287 내지 약 297; 및 약 404 내지 약 430을 걸치는 것을 포함한다. 다른 적당한 단편은 당업자에 의해 용이하게 확인될 수 있다. 추가로, 헥손 단백질은 당업계에 공지된 다양한 목적을 위해 변형될 수 있다. 헥손 단백질이 아데노바이러스의 항원형에 대한 결정요인이기 때문에, 이러한 인공 헥손 단백질은 인공 항원형을 가지는 아데노바이러스를 초래할 수 있다. 다른 인공 캡시드 단백질은 또한 침팬지 Ad 펜톤 서열 및/또는 본 발명의 섬유 서열 및/또는 그것의 단편을 사용하여 구성될 수 있다.
한 구체예에서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 헥손 단백질의 서열을 이용하는 변경된 헥손 단백질을 가지는 아데노바이러스가 발생될 수 있다. 헥손 단백질을 변경하는 한 적절한 방법은 참고로써 포함되는 미국 특허 5,922,315호에서 기술된다. 이 방법에서, 아데노바이러스 헥손의 적어도 하나의 루프 영역은 다른 아데노바이러스 항원형의 적어도 하나의 루프 영역으로 변경된다. 따라서, 이러한 변경된 아데노바이러스 헥손 단백질의 적어도 하나의 루프 영역은 SAdV-39의 유인원 Ad 헥손 루프 영역이다. 한 구체예에서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 헥손 단백질의 루프 영역은 다른 아데노바이러스 항원형으로부터 루프 영역으로써 대체된다. 다른 구체예에서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 헥손의 루프 영역은 다른 아데노바이러스 항원형의 루프 영역을 대체하기 위해 사용된다. 적절한 아데노바이러스 항원형은 본원에서 기술되는 바와 같은 인간과 비-인간 항원형 중으로부터 용이하게 선택될 수 있다. 적당한 항원형의 선택은 본 발명에서 제한되지 않는다. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 헥손 단백질 서열에 대한 또 다른 사용은 당업자에게 용이하게 명백할 것이다.
SAdV-39 [SEQ ID NO:22], SAdV-25.2 [SEQ ID NO: 151], -26 [SEQ ID NO: 183], -30 [SEQ ID NO: 118], -37 [SEQ ID NO: 54] 또는 -38 [SEQ ID NO: 85]의 섬유 단백질의 아미노산 서열이 제공된다. 적절하게는, 이 섬유 단백질, 또는 그것의 독특한 단편은 다양한 목적을 위해 이용될 수 있다. 한 적절한 단편은 SEQ ID NO: 22, 151, 183, 119, 54 또는 85 내에 위치되는 섬유 혹이다. 다른 적절한 단편의 예는 SEQ ID NO: 22, 151, 183, 119, 54 또는 85에서 제공되는 아미노산 넘버링에 기초하여 약 50, 100, 150, 또는 200 아미노산의 N-말단의 및/또는 C-말단의 절단을 가지는 섬유를 포함한다. 또 다른 적절한 단편은 내부 단편을 포함한다. 추가로, 섬유 단백질은 당업자에게 공지된 다양한 기술을 사용하여 변형될 수 있다.
SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 단백질의 독특한 단편은 길이에 있어서 적어도 8개의 아미노산이다. 그러나, 다른 원하는 길이의 단편이 용이하게 이용될 수 있다. 게다가, 변형은 SSAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 유전자 생성물의 수율 및/또는 발현을 향상시키기 위해 도입될 수 있고, 예를 들어, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 유전자 생성물의 모두 또는 단편이 향상을 위해 융합 파트너와 융합되는(직접 또는 링커를 통해) 융합 분자의 구성이 본원에서 제공된다. 다른 적절한 변형은, 제한 없이, 보통 절단되는 전- 또는 후-단백질을 제거하기 위해 및 성숙 단백질 또는 효소 및/또는 비밀 유전자 생성물을 제공하기 위한 코딩 영역의 돌연변이를 제공하기 위해 코딩 영역(예를 들어, 단백질 또는 효소)의 절단을 포함한다. 또 다른 변형은 당업자에게 용이하게 명백할 것이다. 더 나아가 본원에 제공된 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 단백질과 적어도 약 99% 동일성을 가지는 단백질이 포함된다.
본원에서 기술되는 바와 같은, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 아데노바이러스 캡시드 단백질을 함유하는 본 발명의 벡터는 중화벡터가 다른 Ad 항원형계 벡터 뿐만 아니라 다른 바이러스 벡터의 유효성을 감소시키는 용도에서의 사용에 특히 적합하다. rAd 벡터는 반복 유전자 치료 또는 부스팅 면역 반응(백신 타이터)을 위한 재투여에서 특히 유리하다.
특정 환경 하에서, 항체를 발생시키기 위한 하나 이상의 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 유전자 생성물(예를 들어, 캡시드 단백질 또는 그것의 단편)을 사용하는 것이 바람직할 수 있다. 본원에서 사용되는 용어 "항체"는 에피토프에 특이적으로 결합할 수 있는 면역글로불린 분자를 말한다. 항체는, 예를 들어, 고친화도 폴리클로날 항체, 모노클로날 항체, 합성 항체, 키메라 항체, 재조합 항체 및 인간화된 항체를 포함하는 다양한 형태로 존재할 수 있다. 이러한 항체는 면역글로불린 분류 IgG, IgM, IgA, IgD 및 IgE로부터 기원한다.
이러한 항체는 당업계에 알려진 어떤 다수의 방법을 사용하여 발생될 수 있다. 적절한 항체는 잘-알려진 전통적인 기술, 예를 들어, Kohler 및 Milstein, 및 그것의 많은 공지된 변형에 의해 발생될 수 있다. 유사하게, 바람직한 고역가 항체는 이들 항원에서 개발된 모노클로날 또는 폴리클로날 항체에 대한 공지된 재조합 기술을 적용함으로써 발생될 수 있다[예를 들어, PCT 특허 출원 No. PCT/GB85/00392; 영국 특허 출원 공개 번호 GB2188638A; Amit et al., 1986 Science, 233:747-753; Queen et al., 1989 Proc . Nat'l . Acad . Sci . USA, 86: 10029-10033; PCT 특허 출원 번호 PCT/WO9007861; 및 Riechmann et al., Nature, 332:323-327 (1988); Huse et al, 1988a Science, 246: 1275-1281 참조]. 또 다르게는, 항체는 본 발명의 항원에 동물 또는 인간 항체의 상보성 결정 영역을 조작함으로써 생성될 수 있다. 예를 들어, E. Mark and Padlin, "Humanization of Monoclonal Antibodies", Chapter 4, The Handbook of Experimental Pharmacology, Vol. 113, The Pharmacology of Monoclonal Antibodies, Springer-Verlag (June, 1994); Harlow et al., 1999, Using Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press, NY; Harlow et al., 1989, Antibodies: A Laboratory Manual, Cold Spring Harbor, New York; Houston et al., 1988, Proc . Natl. Acad . Sci USA 85:5879-5883; 및 Bird et al., 1988, Science 242:423-426 참조. 추가로 본 발명에 의해 항-유전자형 항체(Ab2) 및 항-항-유전자형 항체(Ab3)가 제공된다. 예를 들어, M. Wettendorff et al., "Modulation of anti-tumor immunity by anti-idiotypic antibodies." In Idiotypic Network and Diseases, ed. by J. Cerny and J. Hiernaux, 1990 J. Am. Soc . Microbiol ., Washington DC: pp. 203-229]. 이들 항-유전자형 및 항-항-유전자형 항체는 당업계에 공지된 기술을 사용하여 생성된다. 이들 항체는 진단적 및 임상적 방법 및 키트를 포함하는 다양한 목적을 위해 사용될 수 있다.
특정 환경 하에서, SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 유전자 생성물, 항체 또는 본 발명의 다른 구조체에 검출가능한 표지 또는 태그를 도입하는 것이 바람직할 수 있다. 본원에서 사용되는 바와 같은, 검출가능한 표지는 단독으로 또는 다른 분자와 상호작용하여, 검출가능한 신호를 제공할 수 있는 분자이다. 가장 바람직하게는, 표지는, 예를 들어, 면역 조직 화학 분석 또는 면역 형광 현미경검사에 의해 시각적으로 검출가능하다. 예를 들어, 적당한 표지는 플루오르세인 이소티오시아네이트 (FITC), 피코에리트린 (PE), 알로피코시아닌(APC), 코리포스핀-O (CPO) 또는 탠덤 염료, PE-시아닌-5 (PC5), 및 PE-텍사스 레드(ECD)를 포함한다. 모든 이들 형광 염료는 상업적으로 이용가능하고, 그것들의 사용은 당업계에 공지되어 있다. 다른 유용한 표지는 콜로이드 골드 표지를 포함한다. 또 다른 유용한 표지는 방사성 화합물 또는 원소를 포함한다. 추가적으로, 표지는 분석에서 측색 신호를 나타내기 위해 작동하는 다양한 효소 시스템을 포함하며, 예를 들어, 글루코오스 옥시다아제(기질로서 글루코오스를 사용)는 페록시다아제 및 테트라메틸 벤지딘(TMB)과 같은 수소 도너의 존재하에서 푸른색으로서 보이는 산화된 TMB를 생성하는 생성물로서 과산화물을 방출한다. 다른 예는 ATP, 글루코오스, 및 NAD+와 반응하는 글루코오스-6-포스페이트 탈수소효소와 함께 양고추냉이과산화효소 (HRP), 알칼리 포스파타아제 (AP), 및 헥소키나아제를 포함하여, 특히 340 nm 파장에서 증가된 흡광도로서 검출되는 NADH를 얻는다.
본원에서 기술되는 방법에서 이용되는 다른 표지 시스템은 다른 수단, 예를 들어, 주입된 염료가 적용가능한 분석에서 결과 복합체의 존재하에서 시각적 신호 표시를 제공하기 위한 표적 서열과 콘쥬게이트를 형성하는 효소 대신에 사용되는 착색 라텍스 마이크로입자[Bangs Laboratories, Indiana]에 의해 검출가능하다.
원하는 분자와 표지를 커플링 또는 결합하는 방법은 마찬가지로 통상적이며 당업자에게 공지되어 있다. 표지 부착의 공지된 방법이 기술된다[예를 들어, Handbook of Fluorescent probes and Research Chemicals, 6th Ed., R.P.M. Haugland, Molecular Probes, Inc., Eugene, OR, 1996; Pierce Catalog and Handbook, Life Science and Analytical Research Products, Pierce Chemical Company, Rockford, IL, 1994/1995 참조]. 따라서, 표지 및 커플링 방법의 선택은 본 발명을 제한하지 않는다.
SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38의 서열, 단백질, 및 단편은 재조합 생성물, 화학적 합성, 또는 다른 합성 수단을 포함하는 임의의 적절한 수단에 의해 생성될 수 있다. 적절한 생성 기술은 당업자에게 잘 공지되어 있다. 예를 들어, Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press (Cold Spring Harbor, NY) 참조. 또 다르게는, 펩티드는 또한 잘 공지된 고체 상 펩티드 합성 방법(Merrifield, J. Am. Chem . Soc, 85:2149 (1962); Stewart and Young, Solid Phase Peptide Synthesis (Freeman, San Francisco, 1969) pp. 27-62)에 의해 합성될 수 있다. 이들 및 다른 적절한 생성 방법은 당업자의 지식 내이며, 본 발명의 범위를 제한하지 않는다.
게다가, 당업자는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 서열이 치료 및 면역 분자의 시험관 내, 생체 밖 또는 생체 내 전달을 위한 다양한 바이러스 및 비-바이러스 벡터 시스템을 위한 사용에 용이하게 적용될 수 있다는 것을 용이하게 이해할 것이다. 예를 들어, 한 구체예에서, 유인원 Ad 캡시드 단백질 및 본원에서 기술되는 다른 유인원 아데노바이러스 단백질은 비-바이러스, 유전자의 단백질계 전달, 단백질 및 기타 바람직한 진단적, 치료적 및 면역적 분자에 대해 사용된다. 한 이러한 구체예에서, 본 발명의 단백질은 아데노바이러스에 대한 수용체와 함께 세포를 표적화하기 위한 분자에 직접 또는 간접적으로 연결된다. 바람직하게는, 헥손, 펜톤, 섬유 또는 세포 표면 수용체를 위한 리간드를 가지는 그것의 단편과 같은 캡시드 단백질이 이러한 표적을 위해 선택된다. 전달에 적당한 분자는 본원에서 기술되는 치료적 분자와 그것의 유전자 생성물 중에서 선택된다. 지질, 폴리Lys 등을 포함하는 다양한 링커가 링커로서 이용될 수 있다. 예를 들어, 유인원 펜톤 단백질은 Medina-Kauwe LK, et al, Gene Ther . 2001년 5월; 8(10):795-803 및 Medina-Kauwe LK, et al, Gene Ther . 2001년 12월; 8(23): 1753-1761에서 기술되는 것과 유사한 방법으로 유인원 펜톤 서열을 사용하여 융합 단백질의 생성에 의한 목적을 위해 용이하게 이용될 수 있다. 또 다르게는, 유인원 Ad 단백질 IX의 아미노산 서열은 미국 특허 출원 20010047081에 기술되는 바와 같은 세포 표면 수용체에 벡터를 표적화하기 위해 이용될 수 있다. 적당한 리간드는 CD40 항원, RGD-함유 또는 폴리리신-함유 서열 등을 포함한다. 예를 들어, 헥손 단백질 및/또는 섬유 단백질을 포함하는 또 다른 유인원 Ad 단백질은 이들 및 유사한 목적을 위해 사용될 수 있다.
또 다른 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스 단백질은 당업자에게 용이하게 명백할 다양한 목적을 위하여 단독으로, 또는 다른 아데노바이러스 단백질과 조합하여 사용될 수 있다. 게다가, SAdV 아데노바이러스 단백질의 또 다른 사용은 당업자에게 용이하게 명백할 것이다.
II. 재조합 아데노바이러스 벡터
본원에 기술되는 조성물은 치료 또는 백신 목적을 위해 세포에 이종성 분자를 전달하는 벡터를 포함한다. 본원에서 사용되는, 벡터는 제한 없이, 네이키드 DNA, 파지, 트랜스포존, 코스미드, 에피솜, 플라스미드, 또는 바이러스를 포함하는 어떤 유전적 요소를 포함할 수 있다. 이러한 벡터는 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 및 미니유전자의 유인원 아데노바이러스를 함유한다. "미니유전자" 또는 "발현 카세트"는 숙주 세포에서 유전자 생성물의 번역, 전사 및/또는 발현을 작동하는데 필요한 선택된 이종성 유전자 및 다른 조절 요소의 조합을 의미한다.
전형적으로, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 -유래된 아데노바이러스 벡터는 설계되어 선택된 아데노바이러스 유전자에 고유한 영역에서 미니유전자는 다른 아데노바이러스 서열을 함유하는 핵산 분자에 위치된다. 미니유전자는 원한다면, 영역의 기능을 방해하기 위해 존재하는 유전자 영역에 도입될 수 있다. 또 다르게는, 미니유전자는 부분적으로 또는 완전히 결실된 아데노바이러스 유전자의 자리에 삽입될 수 있다. 예를 들어, 미니유전자는 특히 선택될 수 있는 기능적 E1 결실 또는 기능적 E3 결실의 자리와 같은 자리에서 위치될 수 있다. 용어 "기능적으로 결실된" 또는 "기능적 결실"은 유전자 영역의 충분한 양이 예를 들어, 돌연변이 또는 변형에 의해 제거 또는 다르게는 손상되어, 유전자 영역은 유전자 발현의 기능적 생성물을 더 이상 생성할 수 없음을 의미한다. 원한다면, 전체 유전자 영역이 제거될 수도 있다. 유전자 파괴 또는 결실을 위한 다른 적절한 자리는 본 출원의 어디에서나 논의된다.
예를 들어, 재조합 바이러스의 발생에 유용한 생성 벡터에 대해, 벡터는 미니유전자 및 아데노바이러스 게놈의 5' 말단 또는 아데노바이러스 게놈의 3' 말단 중 하나, 또는 아데노바이러스 게놈의 5'과 3' 둘 다를 함유할 수 있다. 아데노바이러스 게놈의 5' 말단은 패키징 및 복제에 필요한 5' 시스-구성요소; 즉, 5' 역위 말단 반복 (ITR) 서열(복제의 기원으로서 작용) 및 본래의 5' 패키징 인핸서 도메인(E1 프로모터를 위한 패키징 선형 Ad 게놈 및 인핸서 요소에 필요한 서열을 함유)을 함유한다. 아데노바이러스 게놈의 3' 말단은 패키징 및 단백질 막화(encapsidation)에 필요한 3' 시스-구성요소(ITR을 포함)를 포함한다. 적절하게는, 재조합 아데노바이러스는 5' 및 3' 아데노바이러스 시스-구성요소를 함유하며, 미니유전자는 5' 및 3' 아데노바이러스 서열 사이에 위치된다. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 기초 아데노바이러스 벡터는 또한 추가 아데노바이러스 서열을 함유할 수 있다.
적절하게는, 이들 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 기초 아데노바이러스 벡터는 본 발명의 아데노바이러스 게놈으로부터 유래된 하나 이상의 아데노바이러스 구성요소를 함유할 수 있다. 한 구체예에서, 벡터는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38로부터의 아데노바이러스 ITR 및 동일한 아데노바이러스 항원형으로부터의 추가 아데노바이러스 서열을 함유한다. 다른 구체예에서, 벡터는 ITR을 제공하는 것보다 다른 아데노바이러스 항원형으로부터 유래되는 아데노바이러스 서열을 함유한다.
본원에서 정의되는 바와 같이, 슈도타입화된(pseudotyped) 아데노바이러스는 아데노바이러스의 캡시드 단백질이 ITR을 제공하는 아데노바이러스 보다 다른 아데노바이러스로부터 오는 아데노바이러스를 말한다.
추가로, 키메라 또는 하이브리드 아데노바이러스는 당업자에게 공지된 기술을 사용하여 본원에 기술된 아데노바이러스를 사용하여 구성될 수 있다. 예를 들어, 미국 특허 US 7,291,498호 참조.
ITR의 아데노바이러스 공급원 및 벡터에 존재하는 어떤 다른 아데노바이러스 서열의 공급원은 본 발명을 제한하지 않는다. 다양한 아데노바이러스 균주가 American Type Culture Collection, Manassas, Virginia로부터 이용가능하고, 또는 다양한 상업적 및 기관의 공급원으로부터 이용가능하다. 추가로, 많은 이러한 균주의 서열은 예를 들어, PubMed 및 GenBank를 포함하는 다양한 데이터베이스로부터 이용가능하다. 다른 유인원 또는 인간 아데노바이러스로부터 제조된 상동 아데노바이러스 벡터는 공개된 문헌에서 기술된다[예를 들어, 미국 특허 5,240,846호 참조]. 다수의 아데노바이러스 종류의 DNA 서열은 타입 Ad5[GenBank 등록 번호 M73260]를 포함하여, GenBank로부터 이용가능하다. 아데노바이러스 서열은 항원형 2, 3, 4, 7, 12 및 40과 같은 어떤 공지된 아데노바이러스 항원형으로부터 얻을 수 있고, 또한 어떤 본원에서 확인되는 인간형을 포함한다. 유사하게 비-인간 동물(예를 들어, 유인원)을 감염시키는 것으로 알려진 아데노바이러스는 또한 본 발명의 벡터 구조체에서 사용될 수 있다. 예를 들어, 미국 특허 6,083,716호 참조.
바이러스 서열, 헬퍼 바이러스(필요하다면), 및 재조합 바이러스 입자, 및 다른 벡터 성분 및 본원에 기술되는 벡터의 구조체에서 사용되는 서열은 상기 기술된 바와 같이 획득된다. 본 발명의 SAdV39 , SAdV-25.2, -26, -30, -37 또는 -38 유인원 아데노바이러스 서열의 DNA 서열은 벡터 및 이러한 벡터의 제조에 유용한 셀 라인을 구성하기 위해 사용된다.
서열 결실, 삽입, 및 다른 돌연변이를 포함하는 본 발명의 벡터를 형성하는 핵산 서열의 변형은 표준 분자 생물학적 기술을 사용하여 발생될 수 있고, 본 구체예의 범주 내이다.
A. "미니유전자"
이식 유전자의 선택, "미니유전자"의 클로닝 및 구성 및 바이러스 벡터에 그것의 삽입을 위해 사용되는 방법은 본원에서 제공되는 교시가 주어지는 당업계의 기술 내이다.
1. 이식 유전자
이식 유전자는 관심의 폴리펩티드, 단백질, 또는 다른 생성물을 암호화하는 이식 유전자 옆에 위치하는 벡터 서열에 이종성인 핵산 서열이다. 핵산 코딩 서열은 숙주 세포에서 이식 유전자 전사, 번역 및/또는 발현을 허용하는 방식으로 조절 성분에 작동가능하게 연결된다.
이식 유전자 서열의 조성은 결과 벡터가 위치될 곳에서 사용에 의존할 것이다. 예를 들어, 한 종류의 이식 유전자 서열은 발현이 검출가능한 신호를 생성할 때 리포터 서열을 포함한다. 이러한 리포터 서열은, 제한 없이, DNA 서열 암호화 β-락타마아제, β-갈락토시다아제(LacZ), 알칼린 포스파타아제, 티미딘 키나아제, 녹색 형광 단백질(GFP), 클로람페니콜 아세틸트랜스페라아제(CAT), 루시페라아제, 예를들어, CD2, CD4, CD8를 포함하는 막 결합 단백질, 인플루엔자 헤마그글루티닌 단백질, 및 당업계에 잘 공지된 다른 것을 그것과 관련된 고친화도 항체에서 포함하며, 또는 통상적인 수단, 및 특히 헤마그글루티닌 또는 Myc로부터 항원 태그 도메인에 적절하게 융합된 막 결합 단백질을 포함하는 융합 단백질에 의해 생성될 수 있다. 이들 코딩 서열은, 그것의 발현을 작동시키는 조절 요소와 결합될 때, 효소, 방사선 촬영, 측색, 형광 또는 다른 분광기 분석, 형광 활성화 세포 정렬 분석 및 효소면역분석(ELISA), 방사면역측정법(RIA) 및 면역 조직 화학을 포함하는 면역 분석을 포함하는 통상적인 수단에 의해 검출가능한 신호를 제공한다. 예를 들어, 마커 서열은 LacZ 유전자이며, 신호를 전달하는 벡터의 존재는 베타-갈락토시다아제 활성에 대한 분석에 의해 검출된다. 이식 유전자가 GFP 또는 루시페라아제인 경우, 신호를 전달하는 벡터는 광도계에서 색 또는 광 생성에 의해 시각적으로 측정될 수있다.
한 구체예에서, 이식 유전자는 단백질, 펩티드, RNA, 효소, 또는 촉매적 RNA와 같은 생물 및 의학에서 유용한 생성물을 암호화하는 비-마커 서열이다. 바람직한 RNA 분자는 tRNA, dsRNA, 리보솜 RNA, 촉매적 RNA, 및 안티센스 RNA를 포함한다. 유용한 RNA 서열의 한 예는 처치 동물에서 표적 핵산 서열의 발현을 끝내는 서열이다.
이식 유전자는 암 치료제 또는 백신으로서, 면역 반응의 유발, 및/또는 예방 백신 목적을 위한 예를 들어, 유전적 결함의 치료에 사용될 수 있다. 본원에서 사용되는 바와 같은, 면역 반응의 유발은 분자에서 T 세포 및/또는 체액성 면역반응을 유발하는 분자의 능력(예를 들어, 유전자 생성물)을 말한다. 본 발명은 추가로 예를 들어, 멀티-서브유닛 단백질에 의해 야기되는 질환을 고치거나 또는 완화하기 위해 다양한 이식 유전자를 사용하는 것을 포함한다. 특정 상황에서, 다른 이식 유전자는 단백질의 각 서브유닛을 암호화하고, 또는 다른 펩티드 또는 단백질을 암호화하기 위해 사용될 수 있다. 이는 단백질 서브유닛을 암호화하는 DNA의 크기가 클 때, 예를 들어, 면역글로불린, 혈소판-유래 성장인자, 또는 디스트로핀 단백질에 대해 바람직하다. 멀티-서브유닛 단백질을 생성하기 위한 세포를 위해, 세포는 각각의 다른 서브유닛을 함유하는 재조합 바이러스로 감염된다. 또 다르게는, 단백질의 다른 서브유닛은 동일한 이식 유전자에 의해 암호화될 수 있다. 이 경우에, 단일 이식 유전자는 내부 리보자임 유입 자리(IRES)에 의해 분리된 각 서브유닛에 대한 DNA와 함께, 각각의 서브유닛을 암호화하는 DNA를 포함한다. 이는 각각의 서브유닛을 암호화하는 DNA의 자리가 작을 때, 예를 들어, 서브유닛 및 IRES를 암호화하는 DNA의 전체 크기가 5 킬로베이스 미만일 때, 바람직하다. IRES에 대한 대안으로서, DNA는 번역-후 사건에서 자기-절단하는 2A 펩티드를 암호화하는 서열에 의해 분리될 수 있다. 예를 들어, ML. Donnelly, et al., J. Gen. Virol ., 78(Pt 1): 13-21 (1997년 1월); Furler, S., et al, Gene Ther ., 8(11):864-873 (2001년 6월); Klump H., et al, Gene Ther ., 8(10):811-817(2001년 5월) 참조. 이 2A 펩티드는 IRES보다 상당히 더 작으며, 공간이 제한 인자일 때 사용에 적합하도록 만든다. 그러나, 선택된 이식 유전자가 어떤 생물학적으로 활성인 생성물 또는 다른 생성물, 예를 들어, 연구에 바람직한 생성물을 암호화할 수도 있다.
적당한 이식 유전자는 당업자에 의해 용이하게 선택될 수 있다. 이식 유전자의 선택은 이 구체예를 제한하는 것으로 고려되지 않는다.
2. 조절 요소
미니유전자에 대해 상기 확인된 주요 요소에 더하여, 벡터는 또한 플라스미드 벡터로 트랜스펙팅된 또는 본 발명에 의해 생성되는 바이러스로 감염된 세포에서 그것의 전사, 번역 및/또는 발현을 허용하는 방식으로 이식 유전자에 작동가능하게 연결되는 필요한 통상적인 조절 요소를 포함한다. 본원에 사용되는 바와 같은, "작동가능하게 연결된" 서열은 관심의 유전자와 인접하는 발현 조절 서열 및 트랜스에서 또는 관심의 유전자를 조절하기 위한 거리에서 작용하는 발현 조절 서열을 둘 다 포함한다.
발현 조절 서열은 적절한 전사, 개시, 종결, 프로모터 및 인핸서 서열; 스플라이싱 및 폴리아데닐화(폴리A) 신호와 같은 효율적인 RNA 처리 신호; 세포질 mRNA를 안정화하는 서열; 번역 효율을 향상시키는 서열(즉, Kozak 일치 서열); 단백질 안정성을 향상시키는 서열; 및 필요하다면, 암호화된 생성물의 분비를 향상시키는 서열을 포함한다.
원래의, 구성의, 유도의 및/또는 조직-특이적인 프로모터를 포함하는 매우 다수의 발현 조절 서열은 당업계에 공지되어 있으며 이용될 수 있다. 구성 프로모터의 예는, 제한없이 로우스육종바이러스 (RSV) LTR 프로모터(선택적으로 RSV 인핸서와 함께), 시토메갈로 바이러스(CMV) 프로모터(선택적으로 CMV 인핸서와 함께)[예를 들어, Boshart et al, Cell, 41:521-530 (1985) 참조], SV40 프로모터, 디히드로폴레이트 환원효소 프로모터, β-액틴 프로모터, 포스포글리세롤 키나아제(PGK) 프로모터, 및 EF1α 프로모터[Invitrogen]를 포함한다.
유도성 프로모터는 유전자 발현의 조절을 허용하고 외인성으로 공급된 화합물, 온도와 같은 환경적 인자, 또는 특이적인 생리적 상태의 존재, 예를 들어, 급성 병기, 세포의 특정 분화 상태, 또는 단지 세포를 복제하는 것에 의해 조절될 수 있다. 유도성 프로모터 및 유도성 시스템은, 제한 없이, Invitrogen, Clontech 및 Ariad를 포함하는 다양한 상업적 공급원으로부터 이용가능하다. 많은 다른 시스템이 기술되었고 당업자에 의해 용이하게 선택될 수 있다. 예를 들어, 유도성 프로모터는 아연-유도성 양 메탈로티오닌(MT) 프로모터 및 덱사메타손(Dex)-유도성 마우스 유방 종양 바이러스 (MMTV) 프로모터를 포함한다. 다른 유도성 시스템은 T7 폴리머라아제 프로모터 시스템[WO 98/10088]; 엑디손 곤충 프로모터 [No et al, Proc. Natl . Acad . Sci . USA, 93:3346-3351 (1996)], 테트라사이클린-억제성 시스템[Gossen et al, Proc . Natl . Acad . Sci . USA, 89:5547-5551 (1992)], 테트라사이클린-유도성 시스템[Gossen et al, Science, 268:1766-1769 (1995), 또한 Harvey et al, Curr . Opin . Chem . Biol ., 2:512-518 (1998) 참조]을 포함한다. 다른 시스템은 카스트라디올(castradiol), 디페놀 무리슬레론(diphenol murislerone)을 사용하는 FK506 다이머, VP16 또는 p65, RU486-유도성 시스템[Wang et al, Nat. Biotech., 15:239-243 (1997) 및 Wang et al, Gene Ther ., 4:432-441 (1997)] 및 라파마이신-유도성 시스템[Magari et al, J. Clin . Invest., 100:2865-2872 (1997)]을 포함한다. 일부 유도성 프로모터의 유효성은 시간에 따라 증가한다. 이러한 경우에, 탠덤에서 다양한 억제물질을 삽입함으로써 이러한 시스템, 예를 들어, IRES에 의해 TetR에 연결된 TetR의 효율성을 향상시킬 수 있다. 또 다르게는, 원하는 기능에 대한 스크리닝 전에 적어도 3일을 기다릴 수 있다. 이 시스템의 효율성을 향상시키기 위해 공지된 수단에 의해 원하는 단백질의 발현을 향상시킬 수 있다. 예를 들어, Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element (WPRE)를 사용한다.
다른 구체예에서, 이식 유전자에 대한 원래의 프로모터가 사용될 것이다. 본래 프로모터는 이식 유전자의 발현이 본래 발현을 모방하는 것으로 소망될 때 바람직할 수 있다. 원래 프로모터는 이식 유전자의 발현이 일시적으로 또는 발달적으로, 또는 조직-특이적 방법으로, 또는 특이적 전사 자극에 대한 반응으로 조절되어야 할 때, 사용될 수 있다. 추가 구체예에서, 인핸서 요소, 폴리아데닐화 자리 또는 Kozak 일치 서열과 같은 다른 본래 발현 조절 요소는 또한 본래 발현을 모방하도록 사용될 수 있다.
이식 유전자의 다른 구체예는 조직-특이적 프로모터에 작동가능하게 연결된 이식 유전자를 포함한다. 예를 들어, 골격근에서 발현이 소망된다면, 근육에서 활성인 프로모터가 사용되어야 한다. 이들은 골격의 β-액틴, 미오신 경사슬 2A, 디스트로핀, 근육 크레아틴 키나아제를 암호화하는 유전자로부터의 프로모터뿐만 아니라 자연적으로 발생하는 프로모터보다 더 높은 활성을 가지는 합성 근육 프로모터를 포함한다(Li et al., Nat. Biotech., 17:241-245 (1999)). 조직-특이적인 프로모터의 예는 간(알부민, Miyatake et al, J. Virol , 71 :5124-32 (1997); B형 간염바이러스 코어 프로모터, Sandig et al, Gene Ther ., 3: 1002-9 (1996); 알파-태아 단백질(AFP), Arbuthnot et al., Hum. Gene Ther ., 7: 1503-14 (1996)), 뼈 오스테오칼신(Stein et al, Mol . Biol . Rep., 24:185-96 (1997)); 뼈 시알로단백질(Chen et al, J. Bone Miner. Res., 11:654-64 (1996)), 림프구 (CD2, Hansal et al, J. Immunol, 161:1063-8 (1998); 면역글로불린 중사슬; T 세포 수용체 사슬), 뉴런-특이적 에놀라아제(NSE) 프로모터와 같은 신경세포(Andersen et al, Cell. Mol. Neurobiol, 13:503-15 (1993)), 신경미세섬유 경-사슬 유전자(Piccioli et al, Proc . Natl . Acad . Sci USA, 88:561 1-5 (1991)), 및 특히 뉴런-특이적 vgf 유전자(Piccioli et al, Neuron, 15:373-84 (1995))에 대해 알려져 있다.
선택적으로, 치료적으로 유용한 또는 면역성 생성물을 암호화하는 이식 유전자를 전달하는 벡터는 또한 선택가능한 마커를 포함할 수 있고, 또는 리포터 유전자는 특히 제네티신, 하이그로미신 또는 퓨리마이신 저항을 암호화하는 서열을 포함할 수 있다. 이러한 선택가능한 리포터 또는 마커 유전자(바람직하게는 바이러스 입자안으로 패키징되는 바이러스 게놈 밖에 위치됨)는 암피실린 저항과 같은 박테리아 세포에서 플라스미드의 존재를 표시하는데 사용될 수 있다. 벡터의 다른 성분은 복제의 기원을 포함할 수 있다. 이들 및 다른 프로모터 및 벡터 요소의 선택은 통상적이며 많은 이러한 서열이 이용가능하다[예를 들어, Sambrook et al, 및 그것에 인용된 참고문헌 참조].
이들 벡터는 당업자에게 공지된 기술과 함께, 본원에 제공된 기술 및 서열을 사용하여 발생된다. 이러한 기술은 문헌[Sambrook et al, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, Cold Spring Harbor, NY]에서 기술되는 것과 같은 cDNA의 통상적인 클로닝 기술, 아데노바이러스 게놈의 중복 올리고뉴클레오티드 서열의 사용, 폴리머라아제 연쇄 반응, 및 원하는 뉴클레오티드 서열을 제공하는 어떤 적당한 방법을 포함한다.
III. 바이러스 벡터의 생성
한 구체예에서, 유인원 아데노바이러스 플라스미드(또는 다른 벡터)는 아데노바이러스 벡터를 만드는데 사용된다. 한 구체예에서, 아데노바이러스 벡터는 복제-결함의 아데노바이러스 입자이다. 한 구체예에서, 아데노바이러스 입자는 E1a 및/또는 E1b 유전자에서 결실에 의한 복제-결함이 제공된다. 또 다르게는, 아데노바이러스는, 선택적으로 E1a 및/또는 E1b 유전자를 보유하는 동안 다른 수단에 의한 복제-결함이 제공된다. 아데노바이러스 벡터는 또한 아데노바이러스 게놈에서 다른 돌연변이, 예를 들어, 다른 유전자에서 온도-민감 돌연변이 또는 결실을 함유할 수 있다. 다른 구체예에서, 아데노바이러스 벡터에서 무결함 E1a 및/또는 E1b 영역을 보유하는 것이 바람직하다. 이러한 무결함 E1 영역은 아데노바이러스 게놈에서 그것의 본래 위치에서 위치될 수도 있고 또는 본래 아데노바이러스 게놈에서 결실 자리(예를 들어, E3 영역)에 위치될 수도 있다.
인간(또는 다른 포유동물) 세포에 유전자의 전달을 위해 유용한 유인원 아데노바이러스 벡터의 구성에서, 아데노바이러스 핵산 서열의 범위는 벡터에서 사용될 수 있다. 예를 들어, 모든 또는 일부의 아데노바이러스 지연 초기 유전자 E3은 재조합 바이러스의 부분을 형성하는 유인원 아데노바이러스 서열로부터 제거될 수 있다. 유인원 E3의 기능은 재조합 바이러스 입자의 기능 및 생성에 무관한 것으로 믿어진다. 유인원 아데노바이러스 벡터는 또한 E4 유전자의 적어도 ORF6 영역의 결실을 가지도록, 더 바람직하게는 이 영역, 전체 E4 영역 기능의 불필요한 중복 때문에 구성될 수 있다. 본 발명의 또 다른 벡터는 지연된 초기 유전자 E2a에서 결실을 함유한다. 결실은 또한 유인원 아데노바이러스 게놈의 L5를 통해 어떤 말기 유전자 L1에서 만들어질 수 있다. 유사하게, 중간 유전자 IX 및 IVa2의 결실은 일부 목적에 유용할 수 있다. 다른 결실은 다른 구조적 또는 비-구조적 아데노바이러스 유전자에서 만들어질 수 있다. 상기 논의된 결실은 개개로 사용될 수 있고, 즉, 본원에 기술되는 바와 같은 사용을 위한 아데노바이러스 서열은 단지 단일 영역에서 결실을 함유할 수 있다. 또 다르게는, 전체 유전자 또는 그것의 생물학적 활성을 파괴하는데 효과적인 그것의 부분의 결실은 어떤 조합으로 사용될 수 있다. 예를 들어, 한 예시적인 벡터에서, 아데노바이러스 서열은 E1 유전자 및 E4 유전자, 또는 E1, E2a 및 E3 유전자, 또는 E1 및 E3 유전자, 또는 E3 등의 결실과 함께 또는 결실 없이, E1, E2a 및 E4 유전자의 결실을 가질 수 있다. 상기 논의한 바와 같이, 이러한 결실은 원하는 결과를 이루기 위해 온도-민감 돌연변이와 같은 다른 돌연변이와 조합하여 사용될 수 있다.
어떤 필수 아데노바이러스 서열을 결핍하는 아데노바이러스 벡터(예를 들어, E1a, E1b, E2a, E2b, E4 ORF6, L1, L2, L3, L4 및 L5)는 아데노바이러스 입자의 바이러스 전염력 및 증식에 필요로 되는 비교대상 외 아데노바이러스 유전자 생성물의 존재하에서 배양될 수 있다. 이들 헬퍼 기능은 하나 이상의 헬퍼 구조체(예를 들어, 플라스미드 또는 바이러스) 또는 패키징 숙주 세포의 존재하에서 아데노바이러스 벡터를 배양함으로써 제공될 수 있다. 예를 들어, 1996년 5월 9일 공개되고, 본원에 참고로써 포함된 국제 특허 출원 WO96/13597의 "최소의" 인간 Ad 벡터의 제조에 대해 설명된 기술을 참조.
1. 헬퍼 바이러스
따라서, 미니유전자을 전달하는데 사용되는 바이러스 벡터의 유인원 아데노바이러스 유전자 함량에 의존하여, 헬퍼 아데노바이러스 또는 비-복제 바이러스 단편이 미니유전자를 함유하는 감염 재조합 바이러스 입자를 생성하는데 필요한 충분한 유인원 아데노바이러스 유전자 서열을 제공하기 위해 필요할 수 있다. 유용한 헬퍼 바이러스는 아데노바이러스 벡터 구조체에서 존재하지 않는 및/또는 벡터가 트랜스펙팅되는 패키징 셀 라인에 의해 발현되지 않는 선택된 아데노바이러스 유전자 서열을 함유한다. 한 구체예에서, 헬퍼 바이러스는 복제-결함이며, 상기 기술된 서열에 더하여 다양한 아데노바이러스 유전자를 함유한다. 이러한 헬퍼 바이러스는 E1-발현 셀 라인과 조합하여 바람직하게 사용된다.
헬퍼 바이러스는 또한 Wu et al, J. Biol . Chem ., 264:16985-16987 (1989); K. J. Fisher 및 J. M. Wilson, Biochem. J., 299:49 (1994년 4월 1일)에서 기술된 바와 같은 폴리-양이온 콘쥬게이트로 형성될 수 있다. 헬퍼 바이러스는 선택적으로 제 2 리포터 미니유전자를 함유할 수 있다. 다수의 이러한 리포터 유전자는 당업계에 공지되어 있다. 아데노바이러스 벡터에서 이식 유전자와 다른 헬퍼 바이러스 상의 리포터 유전자의 존재는 독립적으로 모니터링되는 Ad 벡터와 헬퍼 바이러스 둘 다를 허용한다. 이런 제 2 리포터는 정제 시 결과 재조합 바이러스와 헬퍼 바이러스 사이의 분리를 가능하게 하는데 사용된다.
2. 상보성 셀 라인
상기 기술된 어떤 유전자에서 결실된 재조합 유인원 아데노바이러스(Ad)를 발생시키기 위해, 바이러스의 복제 및 전염력에 필수적이라면, 결실된 유전자 영역의 기능은 헬퍼 바이러스 또는 셀 라인, 즉, 상보성 또는 패키징 셀 라인에 의해 재조합 바이러스에 공급되어야 한다. 많은 환경에서, 인간 E1을 발현시키는 셀 라인은 침팬지 Ad 벡터를 서로 보완하기 위해 사용될 수 있다. 본 발명의 침팬지 Ad 서열과 현재 이용가능한 패키징 세포에서 발견되는 인간 AdE1 서열 사이의 다양성에 기인하여, 현재 인간 E1-함유 세포의 사용이 복제 및 생성 과정 동안 복제-가능 아데노바이러스의 생성을 방지하기 때문에 이는 특히 유리하다. 그러나, 특정 환경에서, E1 유전자 생성물을 발현시키고 E1-결핍 유인원 아데노바이러스의 생성에 이용될 수 있는 셀 라인을 이용하는 것이 바람직할 것이다. 이러한 셀 라인은 기술되었다. 예를 들어, 미국 특허 6,083,716호 참조.
원한다면, 선택된 모 셀 라인에서 발현을 위한 프로모터의 전사 조절 하에서 SAdV28로부터 아데노바이러스 E1 유전자를 최소한으로 발현시키는 패키징 세포 또는 셀 라인을 발생시키기 위해 본원에 제공되는 서열을 이용할 수 있다. 유도성 또는 구성적 프로모터는 이 목적을 위해 사용될 수 있다. 이러한 프로모터의 예는 본 명세서의 어디에서나 상세하게 설명된다. 모 세포는 어떤 요망되는 SAdV28 유전자를 발현시키는 신규 셀 라인의 생성을 위해 선택된다. 제한 없이, 이러한 모 셀 라인은 특히 HeLa [ATCC Accession No. CCL 2], A549 [ATCC Accession No. CCL 185], HEK 293, KB [CCL 17], Detroit [예를 들어, Detroit 510, CCL 72] 및 WI-38 [CCL 75] 세포일 수 있다. 이들 셀 라인은 모두 American Type Culture Collection, 10801 University Boulevard, Manassas, Virginia 20110-2209로부터 이용가능하다. 다른 적당한 모 셀 라인은 다른 공급원으로부터 획득될 수 있다.
이러한 E1-발현 셀 라인은 재조합 유인원 아데노바이러스 E1 결실 벡터의 생성에서 유용하다. 추가적으로, 또 다르게는, 하나 이상의 유인원 아데노바이러스 유전자 생성물, 예를 들어, E1a, E1b, E2a, 및/또는 E4 ORF6을 발현시키는 셀 라인은 재조합 유인원 바이러스 벡터의 생성에서 사용되는 바와 같은 본질적으로 동일한 과정을 사용하여 구성될 수 있다. 이러한 셀 라인은 그런 생성물을 암호화하는 필수적 유전자에서 결실된 아데노바이러스를 서로보완하기 위해, 또는 헬퍼-의존 바이러스(예를 들어, 아데노-관련 바이러스)의 패키징에 필요한 헬퍼 기능을 제공하기 위해 이용될 수 있다. 숙주 세포의 제조는 선택된 DNA 서열의 조합과 같은 기술을 수반한다. 이 조합은 통상적인 기술을 이용하여 수행될 수 있다. 이러한 기술은 폴리머라아제 연쇄 반응, 합성 방법, 및 원하는 뉴클레오티드 서열을 제공하는 어떤 다른 적당한 방법과 조합된, 잘 공지되어 있고 상기 인용한 Sambrook et al.에서 기술되는 cDNA 및 게놈 클로닝, 아데노바이러스 게놈의 중복 올리고뉴클레오티드 서열의 사용을 포함한다.
또 다른 대안으로, 필수적인 아데노바이러스 유전자 생성물이 아데노바이러스 벡터 및/또는 헬퍼 바이러스에 의해 트랜스에서 제공된다. 이러한 예에서, 적절한 숙주 세포는 원핵(예를 들어, 박테리아) 세포를 포함하는 어떤 생물학적 유기체, 및 곤충 세포, 효모 세포 및 포유동물 세포를 포함하는 진핵세포로부터 선택될 수 있다. 특히 바람직한 숙주 세포는, 제한 없이, A549, WEHI, 3T3, 10T1/2, HEK 293 세포 또는 PERC6 (이들 둘 다 기능적 아데노바이러스 E1을 발현시킨다) [Fallaux, FJ et al, (1998), Hum Gene Ther, 9:1909-1917], Saos, C2C12, L 세포, HT1080, HepG2 및 일차 섬유아세포, 인간, 원숭이, 마우스, 래트, 토끼 및 햄스터를 포함하는 포유동물로부터 유래된 간세포 및 근원세포와 같은 세포를 포함하는 어떤 포유동물 종 중에서 선택된다. 세포를 제공하는 포유동물 종의 선택은 본 발명을 제한하지 않으며; 포유동물 세포, 즉, 섬유아세포, 간세포, 종양 세포 등의 종류도 아니다.
3. 셀 라인의 바이러스 입자 및 트랜스펙션의 조합
일반적으로, 트랜스펙션에 의해 미니유전자를 포함하는 벡터를 전달할 때, 벡터는 약 1 x 104 세포 내지 약 1 x 1013 세포, 및 바람직하게는 약 105 세포에서 약 5 μg 내지 약 100 μg DNA, 및 바람직하게는 약 10 내지 약 50 μg DNA의 양으로 전달된다. 그러나, 선택된 벡터, 전달 방법 및 선택된 숙주 세포로서 고려하여, 숙주 세포에서 벡터 DNA의 상대적 양은 조절될 수 있다.
벡터는 네이키드 DNA, 플라스미드, 파지, 트랜스포존, 코스미드, 에피솜, 바이러스 등을 포함하여 당업계에 알려진 또는 상기 기재된 어떤 벡터일 수 있다. 벡터의 숙주 세포에 도입은 트랜스펙션, 및 감염을 포함하는 당업계에 공지된 또는 상기 기재된 바와 같은 어떤 수단에 의해 달성될 수 있다. 하나 이상의 아데노바이러스 유전자는 숙주 세포의 게놈에 안정적으로 통합되고, 에피솜으로서 안정적으로 발현되고, 또는 일시적으로 발현될 수 있다. 유전자 생성물은 모두 에피솜에서 일시적으로 발현되거나 안정적으로 통합될 수 있고, 또는 유전자 생성물의 일부는 안정적으로 발현되는 반면, 나머지는 일시적으로 발현될 수도 있다. 추가로, 각각의 아데노바이러스 유전자의 프로모터는 구성적 프로모터, 유도성 프로모터 또는 본래 아데노바이러스 프로모터로부터 독립적으로 선택될 수 있다. 프로모터는 예를 들어, 유기체 또는 세포의 특이적 생리학적 상태에 의해(즉, 분화상태에 의해 또는 복제 또는 정지 세포(quiescent cell)에서) 또는 외인성으로-첨가된 인자에 의해 조절될 수 있다.
숙주 세포에 분자(플라스미드 또는 바이러스)의 도입은 또한 당업자에게 공지되고, 본 명세서를 통해 논의되는 바와 같은 기술을 사용하여 수행될 수 있다. 바람직한 구체예에서, 표준 트랜스펙션 기술, 예를 들어, CaPO4 트랜스펙션 또는 전기천공법이 사용된다.
재조합 바이러스 입자를 생성하기 위해 아데노바이러스의 선택된 DNA 서열뿐만 아니라 이식 유전자 및 다른 벡터 요소의 다양한 중간체 플라스미드에의 조합, 및 플라스미드 및 벡터의 사용은 통상적인 기술을 사용하여 모두 달성된다. 이러한 기술은 문헌[Sambrook et al, 상기 인용]에서 기술되는 것과 같은 cDNA의 통상적인 클로닝 기술, 아데노바이러스 게놈의 중복 올리고뉴클레오티드 서열의 사용, 폴리머라아제 연쇄 반응, 및 원하는 뉴클레오티드 서열을 제공하는 어떤 적당한 방법을 포함한다. 표준 트랜스펙션 및 공동-트랜스펙션 기술, 예를 들어, CaPO4 침지 기법이 사용된다. 사용되는 다른 통상적인 방법은 바이러스 게놈의 상동 재조합, 한천중층에서 바이러스의 플라크, 신호 생성을 측정하는 방법 등을 포함한다.
예를 들어, 원하는 미니유전자-함유 바이러스 벡터의 구성 및 조합에 따라서, 벡터는 헬퍼 바이러스의 존재하에서 패키징 셀 라인 안으로 시험관 내에서 트랜스펙팅된다. 상동 재조합은 헬퍼와 벡터 서열 사이에서 발생하며, 이는 비리온 캡시드로 복제되고 패키징되는 벡터에서 아데노바이러스-이식 유전자 서열을 허용하여, 재조합 바이러스 벡터 입자를 초래한다. 이러한 바이러스 입자를 생성하는 현재의 방법은 트랜스펙션에 기초한다. 그러나, 본 발명은 이러한 방법에 제한되지 않는다.
결과 재조합 유인원 아데노바이러스는 선택된 이식 유전자가 선택된 세포로 이동하는데 유용하다. 패키징 셀 라인에서 성장한 재조합 바이러스에 의한 생체내 실험에서, 본 발명의 E1-결실 재조합 유인원 아데노바이러스 벡터는 이식 유전자를 비-유인원, 바람직하게는 인간, 세포에 이동시키는데 유용함을 증명한다.
IV. 재조합 아데노바이러스 벡터의 사용
재조합 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 기초 벡터는 시험관내, 생체 밖, 및 생체 내 인간 또는 비-유인원 수의과 환자에서 유전자 전달에 유용하다.
본원에 기술되는 재조합 아데노바이러스 벡터는 시험관내 이종성 유전자에 의해 암호화되는 생성물의 생성을 위한 발현 벡터로서 사용될 수 있다. 예를 들어, E1 결실의 위치로 삽입되는 유전자를 함유하는 재조합 아데노바이러스는 상기 기술한 바와 같은 E1-발현 셀 라인에 트랜스펙팅될 수 있다. 또 다르게는, 복제-가능 아데노바이러스는 다른 선택된 셀 라인에서 사용될 수 있다. 트랜스펙팅된 세포는 그 후 통상적인 방법으로 배양되고, 프로모터로부터 유전자 생성물을 발현시키기 위한 재조합 아데노바이러스를 허용한다. 유전자 생성물은 그 후 배양물로부터 단백질 분리 및 회수의 공지된 통상적인 방법에 의해 배양물 배지로부터 회수될 수 있다.
SAdV39, SAdV-25.2, -26, -30, -37 또는 -38-유래 재조합 유인원 아데노바이러스 벡터는 생체내 또는 생체밖에서 조차 선택되는 숙주 세포에 선택된 이식 유전자를 전달할 수 있는 효율적인 유전자 전달 비히클을 제공하며, 유기체는 하나 이상의 AAV 항원형에서 중화 항체를 가진다. 한 구체예에서, rAAV 및 세포는 생체밖에서 혼합되고; 감염 세포는 통상적인 방법을 사용하여 배양되며; 형질도입된 세포는 환자에 재주입된다. 이들 조성물은 치료적 목적 및 보호 면역을 유발하는 것을 포함하는 면역을 위한 유전자 전달에 특히 적합하다.
더 흔하게는, SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 재조합 아데노바이러스 벡터는 하기 기술되는 바와 같은 치료 또는 면역 분자의 전달을 위해 이용될 것이다. 본 발명의 재조합 아데노바이러스 벡터는 재조합 아데노바이러스 벡터의 반복 전달을 수반하는 요법에서 사용에 특히 적합하다는 것이 두 용도에 대해 용이하게 이해될 것이다. 이러한 요법은 전형적으로 바이러스 캡시드가 변형되는 일련의 바이러스 벡터의 전달을 수반한다. 바이러스 캡시드는 각각의 이후의 투여를 위해, 또는 특정 항원형 캡시드의 미리-선택된 수(예를 들어, 1, 2, 3, 4 또는 그 이상)의 투여 후 변형될 수 있다. 따라서, 요법은 제 1 유인원 캡시드와 함께 rAd의 전달, 제 2 유인원 캡시드와 함께 rAd의 전달, 및 제 3 유인원 캡시드와 함께 전달을 수반할 수 있다. 본 발명의 Ad 캡시드를 단독으로, 다른 것과 조합하여, 또는 다른 아데노바이러스와 조합하여(바람직하게는 면역적으로 비-교차반응임) 사용하는 다양한 다른 요법은 당업자에게 명백할 것이다. 선택적으로, 이러한 요법은 다른 비-인간 영장류 아데노바이러스, 인간 아데노바이러스, 또는 본원에 기술되는 것과 같은 인공 서열의 캡시드와 함께 rAd의 투여를 수반할 수 있다. 요법의 각 단계는 단일 Ad 캡시드로 일련의 주입(또는 다른 전달 경로) 후 다른 Ad 공급원으로부터 일련의 다른 캡시드의 투여를 수반할 수 있다. 또 다르게는, SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 벡터는 다른 바이러스 시스템, 비-바이러스 전달 시스템, 단백질, 펩티드, 및 다른 생물학적으로 활성인 분자를 포함하는 다른 비-아데노바이러스-매개 전달 시스템을 수반하는 요법에서 이용될 수 있다.
하기의 섹션은 본 발명의 아데노바이러스 벡터를 통해 전달될 수 있는 예시적인 분자에 초점을 맞출 것이다.
A. 치료 분자의 Ad-매개 전달
한 구체예에서, 상기-기술된 재조합 벡터는 유전자 치료를 위해 공개된 방법에 따라서 인간에 투여된다. 선택된 이식 유전자를 함유하는 유인원 바이러스 벡터는 환자에 투여될 수 있으며, 바람직하게는 생물학적으로 양립가능한 용액 또는 약학적으로 허용가능한 전달 비히클에서 현탁된다. 적당한 비히클은 멸균 식염수를 포함한다. 약학적으로 허용가능한 담체로 공지되고 당업자에게 잘 알려진 다른 수성 및 비-수성 등장 멸균 주사 용액 및 수성 및 비-수성 멸균 현탁액은 본 목적을 위해 사용될 수 있다.
유인원 아데노바이러스 벡터는 표적 세포를 형질도입하고 유전자 전달 및 발현의 충분한 수준을 제공하는데 충분한 양으로 투여되어, 지나친 불리함 없이 또는 의학적으로 허용가능한 생리적인 효과와 함께 치료적 이점을 제공하며, 이는 의학 분야의 당업자에 의해 결정될 수 있다. 투여의 통상적인 및 약학적으로 허용가능한 경로는, 제한되는 것은 아니지만, 망막에 직접적인 전달 및 다른 안구 전달 방법, 간에 직접적인 전달, 흡입, 비강내, 정맥내, 근육내, 기관내, 피하, 피내, 직장, 경구 및 다른 비경구 투여 경로를 포함한다. 투여 경로는, 원한다면, 이식 유전자 또는 질환에 따라서 조합 또는 조절될 수 있다. 투여 경로는 주로 치료되는 질환의 특성에 의존할 것이다.
바이러스 벡터의 투약은 치료되는 질환, 환자의 연령, 체중 및 건강상태와 같은 요인에 주로 의존할 것이고, 따라서 환자들 사이에서 다양할 수 있다. 예를 들어, 바이러스 벡터의 치료적으로 유효한 성인 인간 또는 수의과 투약량은 일반적으로 약 1 x 106 내지 약 1 x 1015 입자, 약 1 x 1011 내지 1 x 1013 입자, 또는 약 1 x 109 내지 1 x 1012 입자 바이러스의 농도를 함유하는 담체의 약 100 μL 내지 약 100 mL의 범위에 있다. 투약량은 동물의 크기 및 투여 경로에 의존하는 범위에 있을 것이다. 예를 들어, 근육내 주사에 대해 적당한 인간 또는 수의적 투약량(약 80 kg 동물)은 단일 자리에 대해 mL 당, 약 1 x 109 내지 약 5 x 1012 입자의 범위에 있다. 선택적으로, 투여의 다양한 자리는 전달될 수 있다. 다른 예에서, 적당한 인간 또는 수의적 투여는 경구 제형에 대해 약 1 x 1011 내지 약 1 x 1015 입자의 범위에 있을 수 있다. 당업자는 투여 경로, 및 재조합 벡터가 사용되기 위한 치료 또는 백신 용도에 따라서 이들 용량을 조절할 수 있다. 이식 유전자의 발현 수준, 또는 면역원, 순환 항체의 수준은 투약량 투여의 빈도를 결정하기 위해 모니터링 될 수 있다. 투여 빈도의 시간을 결정하기 위한 또 다른 방법은 당업자에게 용이하게 명백할 것이다.
선택적 방법 단계는 바이러스 벡터의 투여와 동시에, 또는 전 또는 후에 적당한 양의 짧은 작동 면역 조절자의 환자에서 공동-투여를 수반한다. 선택된 면역 조절자는 본 발명의 재조합 벡터에 대해 관련된 중화 항체의 형성을 억제할 수 있는 또는 벡터의 T 림프구 (CTL) 제거를 억제할 수 있는 약제로서 본원에 정의된다. 면역 조절자는 T 헬퍼 서브셋(TH1 또는 TH2)과 B 세포 사이에서 상호작용을 방해하여 중화 항체 형성을 억제할 수 있다. 또 다르게는, 면역 조절자는 TH1 세포와 CTL 사이의 상호작용을 억제하여 벡터의 CTL 제거의 발생을 감소시킬 수 있다. 다양한 유용한 면역 조절자 및 그것의 사용을 위한 투약량은, 예를 들어, Yang et al., J. Virol., 70(9) (Sept., 1996); 1996년 5월 2일 공개된 국제 특허 출원 번호 WO96/12406; 및 본원에 모두 참고로써 포함되는 국제 특허출원 번호 PCT/US96/03035에서 개시된다.
1. 치료 이식 유전자
이식 유전자에 의해 암호화되는 유용한 치료적 생성물은, 제한 없이, 인슐린, 글루카곤, 성장 호르몬(GH), 파라티로이드 호르몬(PTH), 성장 호르몬 방출 인자(GRF), 여포 자극 호르몬(FSH), 황체 형성 호르몬(LH), 인간 융모성 고나도트로핀(hCG), 혈관내피성장인자(VEGF), 엔지오포이에틴, 엔지오스태틴, 백혈구조혈성장인자 (GCSF), 에리스로포이에틴(EPO), 결합조직 성장인자(CTGF), 염기성 섬유아세포 성장인자 (bFGF), 산성 섬유아세포 성장인자(aFGF), 상피세포성장인자(EGF), 형질전환 성장인자 (TGF), 혈소판 유래 성장인자 (PDGF), 인슐린 성장 인자 1 및 II (IGF-I 및 IGF-II), TGF, 액티빈, 인히빈을 포함하는 형질전환 성장 인자 수퍼패밀리의 어떤 하나, 또는 어떤 뼈 형성 단백질(BMP) BMPs 1-15, 성장 인자의 헤레귤인/뉴레귤린/ARIA/neu 분화 인자(NDF) 패밀리 중 어떤 하나, 신경 성장인자(NGF), 뇌-유래 신경 친화성 인자(BDNF), 뉴로트로핀 NT-3 및 NT-4/5, 섬모 향신경성 인자(CNTF), 신경아교세포계 유래 신경영양 인자(GDNF), 뉴투린, 애그린, 세마포린/콜랩신의 패밀리 중 어떤 하나, 네트린-1 및 네트린-2, 간세포성장인자(HGF), 에프린, 노긴, 소닉 헤지호그 및 티로신 히드록실라아제를 포함하는 호르몬 및 성장 및 분화 인자를 포함한다.
다른 유용한 이식 유전자 생성물은, 제한 없이, 사이토카인 및 림포카인, 예로써, 트롬보포이에틴(TPO), IL-25를 통한 인터류킨(IL) IL-1(예를 들어, IL-2, IL-4, IL-12 및 IL-18을 포함), 단핵세포 화학유인물질 단백질, 백혈병 억제 인자, 과립성 백혈구 - 대식세포 집락 자극인자, 파스(Fas) 리간드, 종양 괴사 인자 및, 인터페론, 및 줄기 세포 인자, flk-2/flt3 리간드를 포함하는 면역 체계를 조절하는 단백질을 포함한다. 면역 체계에 의해 생성되는 유전자 생성물은 또한 본 발명에 유용하다. 이들은, 제한 없이, 면역글로불린 IgG, IgM, IgA, IgD 및 IgE, 키메라 면역글로불린, 인간화된 항체, 단일쇄 항체, T 세포 수용체, 키메라 T 세포 수용체, 단일쇄 T 세포 수용체, 클래스 I 및 클래스 II MHC 분자, 및 공학변형된 면역글로불린 및 MHC 분자를 포함한다. 유용한 유전자 생성물은 또한 상보적 조절 단백질, 막 보조 단백질(MCP), 붕괴 촉진인자(DAF), CR1, CF2 및 CD59를 포함한다.
또 다른 유용한 유전자 생성물은 호르몬, 성장 인자, 사이토카인, 림포카인, 조절 단백질 및 면역 체계 단백질에 대한 수용체 중 어떤 하나를 포함한다. 본 발명은 저밀도 리포단백질(LDL) 수용체, 고밀도 리포단백질(HDL) 수용체, 매우 낮은 밀도 리포단백질(VLDL) 수용체, 및 스캐빈저 수용체를 포함하는 콜레스테롤 조절을 위한 수용체를 포함한다. 본 발명은 또한 글루코코르티코이드 수용체 및 에스트로겐 수용체, 비타민 D 수용체 및 다른 핵 수용체를 포함하는 스테로이드 호르몬 수용체 수퍼패밀리의 멤버와 같은 유전자 생성물을 포함한다. 게다가, 유용한 유전자 생성물은 전사 인자, 예컨대, jun , fos, max, mad, 혈청반응인자(SRF), AP-1, AP2, myb, MyoD 및 마이오제닌, ETS-박스 함유 단백질, TFE3, E2F, ATF1, ATF2, ATF3, ATF4, ZF5, NFAT, CREB, HNF-4, C/EBP, SP1, CCAAT-박스 결합 단백질, 인터페론 조절 인자 (IRF-1), 윌름 종양 단백질, ETS-결합 단백질, STAT, GATA-박스 결합 단백질, 예컨대, GATA-3, 및 날개달린(winged) 나선형 단백질의 포크헤드(forkhead) 패밀리를 포함한다.
다른 유용한 생성물은, 카르바모일 합성효소 I, 오르니틴 트랜스카르바밀라아제, 아르기노숙시네이트 합성효소, 아르기노숙시네이트 리아제, 아르기나아제, 푸마릴아세트아세테이트 가수분해효소, 페닐알라닌 가수분해효소, 알파-1 안티트립신, 글루코오스-6-포스페이트, 포르포빌리노겐 디아미나아제, 인자 VIII, 인자 IX, 시스타티온 베타-합성효소, 가지사슬 케토산 데카르복실라아제, 알부민, 이소발레릴-coA 탈수소효소, 프로피오닐 CoA 카르복실라아제, 메틸 말로닐 CoA 무타아제, 글루타릴 CoA 탈수소효소, 인슐린, 베타-글루코시다아제, 파이루베이트 카르복실레이트, 간 포스포릴라아제, 포스포릴라아제 키나아제, 글리신 데카르복실라아제, H-단백질, T-단백질, 낭포성 섬유증 막단백질 조절자(CFTR) 서열, 및 디스트로핀 cDNA 서열을 포함한다.
다른 유용한 유전자 생성물은 비-천연적으로 발생하는 폴리펩티드, 예컨대, 삽입, 결실 또는 아미노산 치환을 함유하는 비-천연적으로 발생하는 아미노산 서열을 가지는 키메라 또는 하이브리드 폴리펩티드를 포함한다. 예를 들어, 단일-사슬 공학변형된 면역글로불린은 특정 면역타협 환자에서 유용할 수 있다. 비-천연적으로 발생하는 유전자 서열의 다른 종류는 표적의 과발현을 감소시키는데 사용될 수 있는 안티센스 분자 및 촉매적 핵산, 예를 들어 리보자임을 포함한다.
유전자 발현의 감소 및/또는 조절은 암 및 건선과 같이 이상증식 세포를 특징으로 하는 이상증식 질환의 치료에 특히 바람직하다. 표적 폴리펩티드는 정상 세포와 비교하여 이상증식 세포에서 배타적으로 또는 더 높은 수준으로 생성되는 폴리펩티드를 포함한다. 표적 항원은 myb, myc, fyn, 및 전좌 유전자 bcr/abl, ras, src, P53, neu, trk 및 EGRF과 같은 종양유전자에 의해 암호화되는 폴리펩티드를 포함한다. 표적 항원으로서 종양유전자 생성물에 더하여, 항-암 치료를 위한 표적 폴리펩티드 및 보호 요법은 B 세포 림프종에 의해 만들어지는 항체의 가변 영역 및 T 세포 림프종의 T 세포 수용체의 가변 영역을 포함하며, 일부 구체예에서, 이는 또한 자가면역 질병에 대한 표적 항원으로서 사용된다. 다른 종양-관련 폴리펩티드는 모노클로날 항체 17-1A 및 폴레이트 결합 폴리펩티드에 의해 인식되는 폴리펩티드를 포함하는 종양 세포에서 더 높은 수준으로 발견되는 폴리펩티드와 같은 표적 폴리펩티드로서 사용될 수 있다.
다른 적당한 치료 폴리펩티드 및 단백질은 세포 수용체 및 자기-관련 항체를 생성하는 세포를 포함하는 자가면역과 관련된 표적에 대하여 광범위 기초 보호 면역 반응을 부여함으로써 자가면역 질병 및 장애를 겪고 있는 개체를 치료하는데 유용할 수 있는 것들을 포함한다. T 세포 매개 자가면역 질병은 류마티스 관절염(RA), 다발성경화증(MS), 쇼그렌증후군, 유육종증, 인슐린 의존성 당뇨병(IDDM), 자가면역성 갑상샘염, 반응성 관절염, 강직성 척추염, 경피증, 다발성 근염, 건선, 혈관염, 베게너 육아종증, 크론병 및 궤양성 대장염을 포함한다. 각각의 이들 질병은 내인성 항원에 결합하고 자가면역 질병에 관련되는 면역 캐스캐이드를 시작하는 T 세포 수용체(TCR)를 특징으로 한다.
본 발명의 유인원 아데노바이러스 벡터는 특히 이식 유전자의 다양한 아데노바이러스-매개 전달이 요망되는 치료 요법에서, 예를 들어, 동일한 이식 유전자의 회복을 수반하는 요법에서 또는 다른 이식 유전자의 전달을 수반하는 요법과 조합하여 적합하다. 이러한 요법은 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 유인원 아데노바이러스 벡터의 투여 후, 동일한 항원형 아데노바이러스로부터의 벡터와 함께 재-투여를 수반할 수 있다. 특히 바람직한 요법은 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 유인원 아데노바이러스 벡터의 투여를 수반하며, 제 1 투여로 전달되는 벡터의 아데노바이러스 캡시드 서열의 공급원은 하나 이상의 이후의 투여에서 이용되는 바이러스 벡터의 아데노바이러스 캡시드 서열의 공급원과 다르다. 예를 들어, 치료 요법은 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 벡터의 투여 및 동일 또는 다른 항원형의 하나 이상의 아데노바이러스 벡터에 의한 반복 투여를 수반한다. 다른 예에서, 치료 요법은 아데노바이러스 벡터의 투여 후 제 1 전달 아데노바이러스 벡터에서 캡시드의 공급원과 다른 캡시드를 가지는 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 벡터에 의한 반복 투여, 및 선택적으로 투여 단계 전 벡터의 아데노바이러스 캡시드의 공급원과 동일한 또는, 바람직하게는 다른, 벡터에 의한 투여를 수반한다. 이들 요법은 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 유인원 서열을 사용하여 구성되는 아데노바이러스 벡터의 전달에 제한되지 않는다. 오히려, 이들 요법은, 제한 없이, 하나 이상의 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 벡터와 조합하여, 다른 유인원 아데노바이러스 서열(예를 들어, Pan9 또는 C68, C1, 등), 다른 비-인간 영장류 아데노바이러스 서열, 또는 인간 아데노바이러스 서열을 포함하는 다른 아데노바이러스 서열을 용이하게 이용할 수 있다. 이러한 유인원, 다른 비-인간 영장류 및 인간 아데노바이러스 항원형의 예는 본 문서에서 어디에서나 논의된다. 추가로, 이 치료 요법은 비-아데노바이러스 벡터, 비-바이러스 벡터, 및/또는 다양한 다른 치료적으로 유용한 화합물 또는 분자와 조합하여 SAdV39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스 벡터의 자발적 또는 순차적 전달을 수반할 수 있다. 본 발명은 이들 치료 요법에 제한되지 않으며, 다양한 것들이 당업자에게 용이하게 명확할 것이다.
B. 면역성 이식 유전자의 Ad-매개 전달
재조합 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터는 또한 면역성 조성물로서 사용될 수 있다. 본원에 사용된 바와 같이, 면역성 조성물은 체액(예를 들어, 항체) 또는 세포(예를 들어, 세포독성 T 세포) 반응이 포유동물, 및 바람직하게는 영장류에 전달 후 면역성 조성물에 의해 전달되는 이식 유전자 생성물에 고정되는 조성물이다. 재조합 유인원 Ad는 원하는 면역원을 암호화하는 그것의 아데노바이러스 서열 결실 유전자 중 어떤 것을 함유할 수 있다. 유인원 아데노바이러스는 인간 기원의 아데노바이러스와 비교하여 다른 동물 종에서 살아있는 재조합 바이러스 백신으로서 사용에 더 적합할 가능성이 있지만, 이러한 사용에 제한되는 것은 아니다. 재조합 아데노바이러스는 면역 반응의 유발에 결정적이고 병원체의 확산을 제한할 수 있다는 것이 확인된 항원(들)에 대한 어떤 병원체 및 cDNA에 대해 이용가능한 어떤 병원체에 대하여 예방 또는 치료 백신으로서 사용될 수 있다.
이러한 백신(또는 다른 면역원) 조성물은 상기 기술한 바와 간은 적당한 전달 비히클에서 제형화된다. 일반적으로 면역성 조성물에 대한 용량은 치료 조성물에 대해 상기 정의한 범위에 있다. 선택 유전자의 면역의 수준은, 만약에 있다면, 부스터에 대한 필요를 결정하기 위해 모니터링될 수 있다. 혈청에서 항체 타이터의 평가에 따라서, 선택적인 부스터 면역이 요망될 수 있다.
선택적으로, 본 발명의 백신 조성물은, 예를 들어, 보조제, 안정화제, pH 조절제, 보존제 등을 포함하는 다른 성분을 함유하기 위해 제형화될 수 있다. 이러한 성분은 백신 업계에서 당업자에게 잘 공지되어 있다. 적당한 보조제의 예는, 제한없이, 리포좀, 알륨, 모노포스포릴 지질 A, 및 어떤 생물학적으로 활성인 인자, 예로써, 사이토카인, 인터류킨, 케모킨, 리간드 및 최상으로는 그것의 조합을 포함한다. 특정의 이들 생물학적으로 활성인 인자는 생체내, 예를 들어, 플라스미드 또는 바이러스 벡터를 통해 발현될 수 있다. 예를 들어, 이러한 보조제는 항원만을 암호화하는 DNA 백신과 함께 프라이밍 시 발생되는 면역 반응과 비교하여, 항원-특이적 면역 반응을 향상시키기 위해 항원을 암호화하는 프라이밍 DNA 백신과 함께 투여될 수 있다.
재조합 아데노바이러스는 "면역원 양", 즉, 원하는 세포를 트랜스펙팅하기 위해 투여되는 경로에서 효과적이고, 면역 반응을 유발하기 위해 선택되는 유전자의 발현의 충분한 수준을 제공하는 양으로 투여된다. 보호 면역이 제공되는 경우, 재조합 아데노바이러스는 감염 및/또는 재발을 예방하는데 유용한 백신 조성물이 되는 것으로 고려된다.
또 다르게는, 또는 추가로, 본 발명의 벡터는 선택된 면역원에 대한 면역 반응을 유발하는 펩티드, 폴리펩티드 또는 단백질을 암호화하는 이식 유전자를 함유한다. 재조합 SAdV 벡터는 벡터에 의해 발현되는 삽입된 이종성 항원 단백질에서 세포 용해 T 세포 및 항체를 유발할 때 매우 효율적인 것으로 기대된다.
예를 들어, 면역원은 다양한 바이러스 과로부터 선택될 수 있다. 면역 반응이 바람직한 바이러스 패밀리의 예는, 보통 감기의 약 50%의 경우를 초래하는 리노바이러스 속; 폴리오바이러스, 콕사키 바이러스, 에코바이러스 및 A형 간염 바이러스와 같은 인간 엔테로바이러스를 포함하는 엔테로바이러스 속; 및 주로 비-인간 동물에서 발 및 구강 질병을 초래하는 압소바이러스 속을 포함하는 피코르나바이러스 과를 포함한다. 바이러스의 피코르나바이러스 과 내에서, 표적 항원은 VP1, VP2, VP3, VP4, 및 VPG를 포함한다. 다른 바이러스 과는 바이러스의 노워크(Norwalk) 군을 포함하고, 유행성 위장염의 중요한 감염인자인 칼시바이러스 과를 포함한다. 인간 및 비-인간 동물에서 면역 반응을 유발하기 위한 표적 항원에서 사용에 바람직한 또 다른 바이러스 과는 토가바이러스 과이며, 이는 신드비스 바이러스, 로스리버 바이러스 및 베네수엘라, 동부형&서부형 마뇌염, 및 루벨라 바이러스를 포함하는 루비바이러스를 포함하는 알파바이러스 속을 포함한다. 플라비비리다에과는 뎅기열, 황열, 일본 뇌염, 세인트루이스 뇌막염 및 진드기매개 바이러스를 포함한다. 다른 표적 항원은 C형 간염 또는 코로나바이러스과로부터 발생될 수 있으며, 이는 다수의 비-인간 바이러스, 예컨대, 전염성 기관지염(가금류), 돼지 전염성 위장염 바이러스(돼지), 돼지 혈구응집성 뇌척수염 바이러스(돼지), 고양이 전염성 복막염 바이러스(고양이), 고양이 장 코노나바이러스(고양이), 개 코로나바이러스(개), 및 인간 호흡 코로나바이러스를 포함하며, 이는 보통의 감기 및/또는 비-A, B 또는 C형 간염을 야기할 수 있다. 코로나바이러스과 내에서, 표적 항원은 E1 (또한 M 또는 매트릭스 단백질로 불림), E2 (또한 S 또는 스파이크 단백질로 불림), E3 (또한 HE 또는 헤마그글루틴-엘터로오스로 불림) 글리코단백질(모든 코로나바이러스에 존재하지 않음) 또는 N(뉴클레오캡시드)을 포함한다. 또 다른 항원은 베시큘로바이러스속(예를 들어, 소수포형 구내염 바이러스), 및 리사 바이러스속(예를 들어, 광견병)을 포함하는 랩도 바이러스과를 표적으로 할 수 있다.
랩도바이러스 과 내에서, 적당한 항원은 G 단백질 또는 N 단백질로부터 유래될 수 있다. 마르부르크 및 에볼라 바이러스와 같은 출혈열 바이러스를 포함하는 필로바이러스 과는 항원의 적당한 공급원일 수 있다. 파라믹소바이러스 과는 파라인플루엔자 바이러스 타입 1, 파라인플루엔자 바이러스 타입 3, 소 파라인플루엔자 바이러스 타입 3, 루불라바이러스(멈프스 바이러스), 파라인플루엔자 바이러스 타입 2, 파라인플루엔자 바이러스 타입 4, 뉴캐슬병 바이러스(닭), 우역, 홍역 및 개디스템퍼를 포함하는 모르비리바이러스, 호흡기 세포융합 바이러스를 포함하는 뉴모바이러스를 포함한다. 인플루엔자 바이러스는 오소믹소바이러스 과 내로 분류되며 적당한 항원(예를 들어, HA 단백질, N1 단백질)의 공급원이다. 분야바이러스 과는 분야바이러스 속(캘리포니아뇌염, La Crosse), 플레보바이러스(리프트 밸리열), 한타바이러스 (퓨어말라(puremala)는 헤마하긴(hemahagin) 열 바이러스이다), 나이로바이러스(진드기증(Nairobi sheep disease)) 및 다양한 미지정 분야바이러스를 포함한다. 아레나바이러스 과는 LCM 및 라사열 바이러스에 대한 항원의 공급원을 제공한다. 레오 바이러스 과는 레오바이러스, 로타바이러스(어린이에게서 급성위장염을 야기한다), 오르비바이러스, 및 컬티바이러스(콜로라도진드기열, 레봄보(Lebombo) (인간), 말 뇌증, 청설병) 속을 포함한다.
레트로바이러스 과는 고양이 백혈병 바이러스, HTLVI 및 HTLVII, 렌티바이러스(인간 면역결핍 바이러스(HIV), 유인원 면역결핍 바이러스(SIV), 고양이 면역부전 바이러스(FIV), 말 전염성 빈혈 바이러스 및 스푸마바이러스를 포함)로서 인간 및 수의과 질병을 포함하는 옹코리비리날(oncorivirinal) 아과를 포함한다. 렌티바이러스 중에서, 많은 적당한 항원이 기술되었고 용이하게 선택될 수 있다. 적당한 HIV 및 SIV 항원의 예는, 제한 없이, gag, pol, Vif, Vpx, VPR, Env, Tat, Nef, 및 Rev 단백질뿐만 아니라 그것의 다양한 단편을 포함한다. 예를 들어, Env 단백질의 적당한 단편은 gp120, gp160, gp41과 같은 어떤 그것의 서브유닛, 또는 그것의 더 작은 단편, 예를 들어, 길이에 있어 적어도 약 8개의 아미노산을 포함할 수 있다. 유사하게, tat 단백질의 단편이 선택될 수 있다. [미국 특허 5,891,994호 및 미국 특허 6,193,981호 참조] 또한, D.H. Barouch et al, J. Virol., 75(5):2462-2467 (2001년 3월), 및 R.R. Amara, et al, Science, 292:69-74 (2001년 4월 6일)에서 기술되는 HIV 및 SIV 단백질 참조. 다른 예에서, HIV 및/또는 SIV 면역성 단백질 또는 펩티드는 융합 단백질 또는 다른 면역성 분자를 형성하기 위해 사용될 수 있다. 예를 들어, 2001년 8월 2일 공개된 WO 01/54719, 및 1999년 4월 8일 공개된 WO 99/16884에서 기술되는 HIV-1 Tat 및/또는 Nef 융합 단백질 및 면역 요법을 참조. 본 발명은 HIV 및/또는 SIV 면역원성 단백질 또는 본원에 기술되는 펩디드로 제한되지 않는다. 게다가, 이들 단백질에서 다양한 변형이 기술되었고, 또는 당업자에 의해 용이하게 만들어질 수 있었다. 예를 들어, 미국 특허 5,972,596에서 기술되는 변형된 구역 단백질(gag protein)을 참조. 추가로, 어떤 요망되는 HIV 및/또는 SIV 면역원은 단독으로 또는 조합하여 전달될 수 있다. 이러한 조합은 단일 벡터 또는 다중 벡터로부터 발현을 포함할 수 있다. 선택적으로, 다른 조합은 단백질 형태에서 하나 이상의 면역원의 전달과 함께 하나 이상의 발현된 면역원의 전달을 수반할 수 있다. 이러한 조합은 하기에서 더욱 상세하게 논의된다.
파포바바이러스 과는 폴리오마바이러스 아과(BKU 및 JCU 바이러스) 및 파필로마바이러스 아과(암 또는 유두종의 악성 진행과 관련)를 포함한다. 아데노바이러스 과는 호흡기 질병 및/또는 장염을 야기하는 바이러스(EX, AD7, ARD, O. B.)를 포함한다. 파보바이러스 과 고양이 파보 바이러스(고양이 장염), 고양이 범백혈구감소증 바이러스, 개 파보바이러스 및 돼지 파보바이러스. 헤르페스바이러스 과는 심플렉스바이러스 속 (HSVI, HSVII), 바리셀로바이러스 (가성광견병, 바리셀라-조스터 바이러스)를 포함하는 알파헤르페스바이러스 아과 및 시토메갈로 바이러스(HCMV, 무로메갈로바이러스)를 포함하는 베타헤르페스바이러스 아과 및 림포크립토바이러스 속, EBV (버킷 임파종(Burkitts lymphoma)), 전염성비기관염, 마렉병 바이러스, 및 라디노바이러스를 포함하는 감마헤르페스바이러스 아과를 포함한다. 수두 바이러스과는 오르토폭스바이러스(바리올라 (두창) 및 백시니아 (우두)), 파라폭스바이러스, 아비폭스바이러스, 카프리폭스바이러스, 레포리폭스바이러스, 수이폭스바이러스 속을 포함하는 초르도폭스바이러스아과, 및 엔토모폭스바이러스 아과를 포함한다. 헤파드나바이러스 과는 B형 간염 바이러스를 포함한다. 적당한 항원의 공급원일 수 있는 한 미분류 바이러스는 델타감염 바이러스이다. 또 다른 바이러스 공급원은 조류 전염성 훼브리셔스낭병 바이러스 및 돼지 호흡기 생식기 증후군 바이러스를 포함할 수 있다. 알파바이러스 과는 말동맥염바이러스 및 다양한 뇌염바이러스를 포함한다.
다른 병원체에 대한 인간 또는 비-인간 동물을 면역화하는데 유용한 면역원은, 예를 들어, 인간 및 비-인간 척추동물을 감염시키는 박테리아, 진균, 기생충미생물 또는 다세포 기생충, 또는 암 세포 또는 종양 세포를 포함한다. 박테리아 병원체의 예는 폐렴쌍구균; 포도상구균; 및 연쇄상구균을 포함하는 병원체의 그램양성 구균을 포함한다. 병원체의 그램-음성 구균은 뇌척수막염균; 임균을 포함한다. 병원체의 장 그램-음성 간균은 장내세균(enterobacteriaceae); 슈도모나스, 아시네토박테리아 및 에이케넬라; 멜리오이도시스; 살모넬라; 시겔라; 헤모필루스; 모락셀라; H. 듀크레이(무른 궤양을 야기함); 브루셀라균; 프란시셀라 툴라렌시스균(툴라레미아를 야기); 예르시니아(파스튜렐라); 모닐리포르미스사슬막대균 및 나선균을 포함하고; 그램-양성 간균은 리스테리아모노사이토제네스; 돈단독균(erysipelothrix rhusiopathiae); 코리네박테리움 디프테리아(디프테리아); 콜레라; 탄저균 (탄저병); 도노반증(서혜육아종); 및 바르토넬라증을 포함한다. 병원성 혐기성 세균에 의해 야기되는 질병은 파상풍; 보툴리즘; 다른 클로스트리디아; 결핵; 나병; 및 다른 마이코박테리아를 포함한다. 병원성 스피로헤타병은 매독; 트레포네마병: 매종, 핀타 및 풍토병성 매독; 및 렙토스피라병을 포함한다. 더 고등의 병원체 박테리아 및 병원성 진균에 의해 야기되는 다른 감염은 방선균증; 노카르디아증; 효모균증, 분아진균증, 히스토플라스마증 및 콕시디오이데스 진균증; 칸디다증, 아스페르길루스증, 및 뮤코르 진균증; 스포로트릭스증; 파라콕시디오이드마이세스증, 페트리엘리듐증, 토룰롭시스증, 균종 및 색소진균증; 및 피부사상균증을 포함한다. 리케차감염은 발진티푸스, 로키산 홍반열, Q열, 및 리켓치아폭스를 포함한다. 마이코플라스마 및 클라미디아 감염의 예는: 마이코플라즈마 뉴모니아; 서혜 림프 육아종; 앵무새병; 및 주산기 클라미디아 감염을 포함한다. 병원성 진핵생물은 병원성 원생동물 및 장내 기생충을 포함하고, 이에 의해 생성되는 감염은: 아메바성 감염; 말라리아; 리슈만편모충증; 트리파노소마증; 톡소플라스마증; 폐포자충(Pneumocystis carinii); 트리칸스(Trichans); 톡소포자충(Toxoplasma gondii) ; 바베스열원충증; 지알디아증; 선모충병; 필라리아병; 주혈흡충병; 선충; 흡충 또는 요행; 및 촌충류(촌충) 감염을 포함한다.
다수의 이들 유기체 및/또는 이에 의해 생성되는 독소는 생물학적 공격에서 사용을 위한 가능성을 가지는 약제로서 질병 대책 센터(Centers for Disease Control)[(CDC), Department of Heath and Human Services, USA]에 의해 확인되었다. 예를 들어, 일부의 이들 생물학적 약제는 탄저균 (탄저병), 클로스트리디움 보툴리늄 및 그것의 독소(보툴리즘), 페스트균(Yersinia pestis)(흑사병), 대두창(두창), 프란키셀라 툴라렌시스(Francisella tularensis)(툴라레미아), 및 바이러스성 출혈열[필로바이러스(예를 들어, Ebola, Marburg], 및 아레나바이러스[예를 들어, Lassa, Machupo])를 포함하며, 이들 모두는 현재 카테고리 A 약제로서 분류되며; 콕시엘라 부르네티(Q 열); 브루셀라 종(브루셀라병), 비저균(Burkholderia mallei)(마비저), 부르코홀데리아 슈도 말레이(Burkholderia pseudomallei)(유비저), 피마자 및 그것의 독소(리신 독소), 클로스트리듐 균(clostridium perfringen) 및 그것의 독소(엡실론 독소), 포도상구균 종 및 그것의 독소(엔테로톡시 B), 클라미디아 시타시(앵무새병), 물의 안전성 위협(예를 들어, 비브리오콜레라, 크립토스포리듐 파르붐), 발진티푸스(리케챠 포와제키(Rickettsia powazekii)), 및 바이러스성뇌염(알파바이러스, 예를 들어, 베네수엘라마뇌염; 동부형마 뇌막염; 서부형 마뇌염)를 포함하고; 이들 모두는 카테고리 B 약제로서 분류되고; 니판 바이러스 및 한타바이러스를 포함하고, 이것은 카테고리 C 약제로서 분류된다. 게다가, 이렇게 분류 또는 다르게 분류되는 다른 유기체는 장래의 목적을 위해 확인 및/또는 사용될 수 있다. 본원에서 기술되는 바이러스 벡터 및 다른 구조체는 이들 유기체, 바이러스, 그것의 독소 또는 다른 부산물로부터, 이들 생물학적 약제에 의한 감염 또는 다른 역반응을 예방 및/또는 치료할 항원을 전달하는데 유용하다는 것이 이해될 것이다.
T 세포의 가변 영역에 대해 면역원을 전달하는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터의 투여는 이들 T 세포를 제거하기 위해 CTL을 포함하는 면역반응을 일으키는 것으로 예상된다. RA에서, 질병에 수반되는 TCR의 몇몇의 특정 가변 영역은 특성이 기술되었다. 이들 TCR은 V-3, V-14, V-17 및 Vα-17을 포함한다. 따라서, 적어도 하나의 이들 폴리펩티드를 암호화하는 핵산 서열의 전달은 RA에 수반된 T 세포를 표적화할 면역반응을 유발할 것이다. MS에서, 질병에 수반된 TCR의 몇몇 특정 가변 영역은 특성이 기술되었다. 이들 TCR은 V-7 및 Vα-10을 포함한다. 따라서, 적어도 하나의 이들 폴리펩티드를 암호화하는 핵산 서열의 전달은 MS에 수반되는 T세포를 표적화할 면역반응을 유발할 것이다. 경피증에서, 질병에 수반된 TCR의 몇몇 특정 가변 영역은 특성이 기술되었다. 이들 TCR은 V-6, V-8, V-14 및 Vα-16, Vα-3C, Vα-7, Vα-14, Vα-15, Vα-16, Vα-28 및 Vα-12을 포함한다. 따라서, 적어도 하나의 이들 폴리펩티드를 암호화하는 재조합 유인원 아데노바이러스의 전달은 경피증에 수반된 T 세포를 표적화할 면역 반응을 일으킬 것이다.
C. Ad-매개 전달 방법
선택된 유전자의 치료 수준, 또는 면역의 수준은, 만약에 있다면, 부스터에 대한 필요를 결정하기 위해 모니터링될 수 있다. 혈청에서 CD8+ T 세포 반응, 또는 선택적으로 항체 타이터의 평가에 따라서, 선택적인 부스터 면역화가 요망될 수 있다. 선택적으로, 재조합 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터는 단일 투여에서 또는 예를 들어, 다른 활성 성분을 수반하는 요법 또는 치료의 과정과 조합하는 다양한 요법 또는 프라임-부스트 요법에서 전달될 수 있다. 다양한 이러한 요법은 당업계에서 기술되었고 용이하게 선택될 수 있다.
예를 들어, 프라임-부스트 요법은 일차 면역 체계로 DNA(예를 들어, 플라스미드) 기초 벡터를, 이차의 부스터로 이러한 항원을 암호화하는 서열을 전달하는 단백질 또는 재조합 바이러스와 같은 일반적인 항원의 투여를 수반할 수 있다. 예를 들어, 참고로써 포함되는 2000년 3월 2일 공개된 WO 00/11140 참조. 또 다르게는, 면역 요법은 항원, 또는 단백질을 전달하는 벡터(바이러스 또는 DNA-기초)에 대한 면역 반응을 촉진하기 위해 재조합 SAdV-39, SAdV-25.2, -30, -37 또는 -38 벡터의 투여를 수반할 수 있다. 또 다른 대안으로, 면역 요법은 단백질의 투여 후 항원을 암호화하는 벡터와 함께 부스터를 수반한다.
한 구체예에서, 상기 항원을 전달하는 플라스미드 DNA 벡터를 전달한 후 재조합 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터로 부스팅함으로써 선택된 항원에서 면역반응을 프라이밍하고 부스팅하는 방법이 기술된다. 한 구체예에서, 프라임-부스트 요법은 프라임 및/또는 부스트 비히클로부터 멀티단백질의 발현을 수반한다. 예를 들어, HIV 및 SIV에 대한 면역 반응을 발생시키는데 유용한 단백질 서브유닛의 발현에 대한 멀티단백질 요법을 기술하는 R. R. Amara, Science, 292:69-74 (2001년 4월 6일) 참조. 예를 들어, DNA 프라임은 단일 전사로부터 Gag, Pol, Vif, VPX 및 Vpr 및 Env, Tat, 및 Rev를 전달할 수 있다. 또 다르게는, SIV Gag, Pol 및 HIV-1 Env는 재조합 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 아데노바이러스 구조체에서 전달된다. 또 다른 요법은 WO 99/16884 및 WO 01/54719에서 기술된다.
그러나, 프라임-부스트 요법은 HIV에 대한 면역 또는 이들 항원의 전달에 제한되지 않는다. 예를 들어, 프라이밍은 제 1 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터에 의한 전달단계 후 제 2 Ad 벡터로, 또는 단백질 형태에서 항원 그 자체를 함유하는 조성물과 함께 부스팅하는 단계를 수반할 수 있다. 한 예에서, 프라임-부스트 요법은 항원이 유래된 바이러스, 박테리아 또는 다른 유기체에 대한 보호 면역 반응을 제공할 수 있다. 다른 구체예에서, 프라임-부스트 요법은 치료제가 투여되는 질환의 존재의 검출을 위한 통상적인 분석을 사용하여 측정될 수 있는 치료효과를 제공한다.
프라이밍 조성물은 요망되는 면역 반응이 표적화되는 항원에 따라서 용량 의존적 방법으로 다양한 자리에 투여될 수 있다. 주사(들)의 양 또는 위치 또는 약학적 담체는 제한되지 않는다. 오히려, 요법은 이들 각각이 매 시간마다, 매일, 주마다 또는 매월 또는 매년마다 투여되는 단일 용량 또는 투약량을 포함할 수 있는 프라이밍 및/또는 부스팅 단계를 수반할 수 있다. 예로서, 포유동물은 담체에서 약 10 μg 내지 약 50 μg의 플라스미드를 함유하는 하나 이상의 용량을 수용할 수 있다. DNA 조성물의 바람직한 양은 약 1 μg 내지 약 10,000 μg의 DNA 벡터의 범위에 있다. 투약량은 피험자 체중 당 1 μg 내지 1000 μg DNA로 다양할 것이다. 전달의 양 또는 자리는 포유동물의 동일성 및 질환에 기초하여 바람직하게 선택된다.
포유동물에 대한 항원의 전달에 적당한 벡터의 투약 단위는 본원에서 기술된다. 벡터는 등장 식염수; 등장 염 용액 또는 이러한 투여에서 당업자에게 명백할 다른 제형과 같은 약학적으로 또는 생리학적으로 허용가능한 담체로 현탁 또는 용해됨으로써 투여를 위해 제조된다. 적절한 담체는 당업자에게 명백할 것이고 투여 경로의 상당 부분에 의존할 것이다. 본원에 기술되는 조성물은 상기 기술된 경로에 따라서, 서방성 제형으로 생체분해가능한 생체적합성 폴리머를 사용하여, 또는 미셀, 겔 및 리포좀을 사용하는 현장 전달에 의해 포유동물에 투여될 수 있다. 선택적으로, 프라이밍 단계는 또한 본원에 기술되는 바와 같은 프라이밍 조성물, 적당한 양의 보조제와 함께 투여하는 단계를 포함한다.
바람직하게는, 부스팅 조성물은 포유동물 피험자에 대해 프라이밍 조성물을 투여 후 약 2 내지 약 27주에 투여된다. 부스팅 조성물의 투여는 프라이밍 DNA 백신에 의해 투여되는 동일한 항원을 함유하는 또는 전달할 수 있는 부스팅 조성물의 유효량을 사용하여 수행된다. 부스팅 조성물은 동일한 바이러스 공급원(예를 들어, 본 발명의 아데노바이러스 서열) 또는 다른 공급원으로부터 유래된 재조합 바이러스 벡터로 구성될 수 있다. 또 다르게는, "부스팅 조성물"은 프라이밍 DNA 백신에서, 그러나 조성물이 숙주에서 면역 반응을 유발하는 단백질 또는 펩티드의 형태로 암호화되는 바와 같은 동일한 항원을 함유하는 조성물일 수 있다. 다른 구체예에서, 부스팅 조성물은 포유동물 세포에서 그것의 발현을 지시하는 조절 서열, 예를 들어, 잘-공지된 박테리아 또는 바이러스 벡터와 같은 벡터의 제어하에서 항원을 암호화하는 DNA 서열을 함유한다. 부스팅 조성물의 일차적 요건은 조성물의 항원이 프라이밍 조성물에 의해 암호화되는 동일 항원, 또는 교차-반응 항원이다.
다른 구체예에서, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터는 또한 다양한 다른 면역 및 치료 요법에서 사용을 위해 적합하게 된다. 이러한 요법은 다른 항원형 캡시드의 Ad 벡터와 함께 동시에 또는 순차적으로 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터의 전달, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터가 동시에 또는 순차적으로 비-Ad 벡터와 함께 전달되는 요법, SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 벡터가 동시에 또는 순차적으로 단백질, 펩티드 및/또는 다른 생물학적으로 유용한 치료 또는 면역원성 화합물과 함께 전달되는 요법을 수반할 수 있다. 이러한 사용은 당업자에게 용이하게 명백할 것이다.
또 다른 구체예에서, 본 발명은 이들 바이러스의 캡시드(선택적으로 무결함 또는 재조합 바이러스 입자 또는 중공 캡시드)의 사용이 아데노바이러스 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38을 피험자에 전달함으로써 다른 활성 약제에서 면역조절 효과 반응을 유발하기 위해, 또는 세포독성 T 세포 반응을 향상 또는 보조하기 위해 사용된다는 것을 제공한다. SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 캡시드는 단독으로 또는 그것에 면역 반응을 향상시키기 위해 활성 약제와 요법을 조합하여 전달될 수 있다. 유리하게는, 요망되는 효과는 아군 E 아데노바이러스에 의해 숙주를 감염시키지 않고 수행될 수 있다. 다른 양태에서, 피험자에 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 캡시드를 전달하는 단계를 포함하는 그것이 필요한 피험자에서 인터페론 알파 생성을 유발하는 방법이 제공된다. 또 다른 양태에서, 배양물에서 하나 이상의 시토킨(예를 들어, IFN-α)/케모킨)을 생성하기 위한 방법이 제공된다. 이 방법은 특히 알파 인터페론을 포함하는 사이토카인/케모킨을 생성하는데 적당한 조건하에서 수지상 세포를 함유하는 배양물 및 본원에 기술되는 SAdV-39, SAdV-25.2, -26, -30, -37 또는 -38 캡시드를 배양하는 단계를 수반한다.
이렇게 생성된 사이토카인은 다양한 용도에서 유용하다. 예를 들어, IFNα의 경우에, 박테리아에서 생성된 IFNα의 단지 하나 또는 두 가지의 서브타입을 함유하는 상업적으로 이용가능한 재조합적으로 생성된 IFNα에 대한 이점을 제공할 것으로 믿어지기 때문에, 본원에 기술되는 생성은 특히 바람직하다. 대조적으로, 본 방법은 천연 인간 IFNα의 다양한 서브타입을 생성하는 것으로 예상되며, 더 넓은 작용의 스펙트럼을 초래하는 것으로 기대된다. 각 서브타입은 특이적 생물학적 활성을 사용하는 것으로 믿어진다. 추가로, 본원에서 제공되는 방법에 의해 생성되는 천연 인터페론은 환자의 자연적으로 생성된 인터페론과 면역학적으로 구별되지 않을 것이며, 이에 의해 보통 재조합적으로 생성된 인터페론에 대해 중화항체의 형성에 의해 야기되는 피험자의 면역 시스템에 의해 거부되는 약물의 위험을 감소시킨다.
하기 예는 SAdV-39, SAdV-25.2, -26, 30, -37 또는 -38의 클로닝 및 대표적인 재조합 SAdV-39, SAdV-25.2, -26, 30, -37 또는 -38 벡터의 구성을 예시한다. 이들 예는 단지 예시적인 것이며, 본 발명의 범주를 제한하는 것은 아니다.
실시예 1 - 유인원 아데노바이러스의 분리.
University of Louisiana New Iberia Research Center, 4401 W. Admiral Doyle Drive, New Iberia, Louisiana, USA에서 침팬지 집단, 및 Michael E. Keeling Center for Comparative Medicine and Research, University of Texas M. D. Anderson Cancer Center, Bastrop, Texas, USA에서 침팬지 집단으로부터 채변 샘플을 얻었다. 행크스 평형화 염 용액의 현탁액에서 침팬지 채변 샘플로부터의 상청액을 0.2 미크론 실린지 필터를 통해 멸균 여과하였다. 100 μl의 각각의 여과된 샘플을 인간 셀 라인 A549 배양물에 접종하였다. 이들 세포를 10% FBS, 1% Penn-Strep 및 50μg/ml 겐타마이신과 함께 Ham's F12에서 성장시켰다. 배양물에서 약 1 내지 2주 후, 시각적 세포변성 효과(CPE)는 몇몇의 접종물과 함께 세포 배양물에서 명백하였다. 아데노바이러스를 아데노바이러스 정제를 위한 표준 공개된 염화세슘 기울기 기술을 사용하여 A549 세포에서 배양물로부터 정제하였다. 정제한 아데노바이러스로부터 DNA를 분리하였고 Qiagen Genomic services, Hilden, Germany에 의해 완전히 서열화하였다.
바이러스 DNA 서열의 계통발생적 분석에 기초하여, 아데노바이러스 지정된 유인원 아데노바이러스 25.2 (SAdV-25.2), 유인원 아데노바이러스 26 (SAdV-26), 유인원 아데노바이러스 30 (SAdV-30), 유인원 아데노바이러스 37 (SAdV-37), 유인원 아데노바이러스 38, (SAdV-38) 및 유인원 아데노바이러스 39 (SAdV-39)를 인간 아군 E로서 동일 아군 내가 되도록 결정하였다.
서열 분석은 SAdV-26의 헥손에 서열 분석은 가장 가까운 헥손 매치는 침팬지 아데노바이러스 6 (98.4 퍼센트 (%) 동일성)이고 가장 가까운 섬유소 매치는 인간 아데노바이러스 4(93% 동일성)라는 것을 나타내었다.
서열 분석은 SAdV25.2 바이러스의 가장 가까운 게놈의 매치는 유인원(침팬지) 아데노바이러스 25 [Genbank 등록 번호 AC000011]라는 것을 나타내었다. SAdV25는 이전에 C68 또는 Pan9 [미국 특허 6083716호]로 명명되었다. 핵산 수중에서, 벡터 NTI-AlignX에 의해 결정되는 바와 같이 SAdV25.2 및 SAdV25 사이에 94% 동일성이 있다. 헥손(아미노산) 수준에서, SAdV-25.2는 2개의 보존적 아미노산 변화와 2개의 비-보존적 변화를 가지는 유인원 아데노바이러스 25와 99% 동일성을 가진다. 하기 표는 SEQ ID NO: 140에서 본원에서 제공되는 SAdV25.2의 헥손에 관하여 SAdV25 헥손 서열과 비교하여, SAdV25.2에서 아미노산 변화를 나타낸다. 두 서열의 넘버링은 동일하다.
Figure pat00008
벡터를 만들기 위해 사용되는 방법은 전체 E1-결핍 아데노바이러스 벡터의 박테리아 플라스미드 분자 클론을 우선 만든 다음 E1 보완 셀 라인 HEK 293에 플라스미드 DNA의 트랜스펙션을 하여 바이러스 벡터를 구제한다.
E1-결핍 아데노바이러스 벡터의 분자 클론을 만들기 위해, 희소-절단 제한 효소 I-CeuI 및 PI-SceI에 대한 인식 자리가 E1 결핍 대신에 삽입된 곳에서 E1-결핍 아데노바이러스의 플라스미드 분자 클론을 우선 만들었다. I-CeuI 및 PI-SceI 옆에 위치하고, 이들 제한 효소를 사용하여 절단한 발현 카세트를 E1-결핍 아데노바이러스 플라스미드 클론에 연결하였다. E1 결핍 대신에 요망되는 발현 카세트를 포함하는 플라스미드 아데노바이러스 분자 클론을 HEK 293 세포에 트랜스펙팅하여 재조합 아데노바이러스 벡터를 구제하였다. 트랜스펙션 다음의 구제는 제한 효소 분해에 의해 플라스미드로부터 선형의 아데노바이러스 게놈을 우선 방출함으로써 가능하게 된다는 것을 발견하였다.
실시예 2 - 표준 분자 생물학 기술을 사용하는 SAdV -39, SAdV -25.2, SAdV -26, SAdV-30, SAdV-37, 또는 SAdV-38에 기초한 E1-결핍 플라스미드 분자 클론의 구성.
A. SAdV-39의 벡터 구성
SAdV-39 (아군 E)를 사용하는 E1 결핍 벡터를 설명한 바와 같이 제조하였다.
1. pSR3의 구성:
SwaI 자리 옆에 위치하는 SmaI, HindII, EcoRV 자리를 함유하는 링커를 다음과 같이 EcoRI 및 NdeI에 의해 pBR322 절단으로 클로닝하였다.
올리고머 SEQ ID NO: 196: SV25 Top: AATTATTTAAATCCCGGGTATCAA-GCTTGATAGATATCATTTAAAT 및 SEQ ID NO: 197: SV25 Bot TAATTTAAATGATATCTATCAAGCTTGATACCCGGGATTTAAAT를 함께 어닐링하여 링커를 만들었다.
2. HindIII 자리(7152)에서 SAdV-39 바이러스 왼쪽 말단의 클로닝
바이러스 DNA를 HindIII로 분해하였고 7152 bp 왼쪽 말단 단편을 SmaI 및 HindIII로 분해한 pSR3에 클로닝하여 pSR3 C39 LE를 수득하였다.
3. I-CeuI 및 PI-SceI 자리의 E1 기능적 결실 및 삽입:
플라스미드 pC39LE는 SnaBI 및 NdeI (Klenow 채워짐) 사이에서 결실되어 E1a 및 대부분의 E1b 코딩 영역을 결실하였고; 그 자리에서, DNA 단편(I-CeuI 및 PI-Scel에 대한 pBleuSK I-PI 포함 자리로부터 EcoRV 단편)을 연결하여 pC39LEIP를 수득하였다.
4. NheI 자리 (35779)로부터 SAdV-39 바이러스 오른쪽 말단의 클로닝.
SAdV-39 바이러스 DNA를 NheI로 분해하였고, 775 bp 오른쪽 말단 단편을 EcoRV 및 NheI 사이의 pC39LEIP에 클로닝하여 pC39LE IP RE를 수득하였다.
5. SAdV-39 바이러스 NheI (3033 - 35779) 단편의 클로닝
플라스미드 pC37-LE-IP-RE를 HindIII로 분해하였고, 32746 bp 바이러스 NheI 단편을 연결하였다. 정확한 방향성(orientaion)을 가지는 클론을 pC39 IP로 불렀다.
B. 표준 분자 생물학 기술을 사용하는 SAdV -25.2에 기초한 E1-결실 플라스미드 분자 클론의 구성.
SAdV-25.2 (아군 E)를 사용하는 E1 결실 벡터를 설명한 바와 같이 제조하였다.
1. pSR6의 구성:
PacI 자리 측면에 위치되는 SmaI, AscI, AvrII, EcoRV 자리를 함유하는 링커를 하기와 같이 EcoRI 및 NdeI에 의한 pBR322 절단으로 클로닝한다.
올리고머 SEQ ID NO: 198: pSR6 top: AATTTTAATTAACCCGGGTATCGGC- GCGCCTTAACCTAGGGATAGATATCTTAATTAA 및 SEQ ID NO: 199: pSR6 bot: TATTAATTAAGATATCTATCCCTAGGTTAAGGCGCGCCGATACCCGGGTTAATTAA를 어닐링하여 링커를 만들었다.
2. AscI 자리(7959)에 바이러스 왼쪽 말단의 클로닝
바이러스 DNA를 AscI로 분해하였고, 7959 bp 왼쪽 단편을 SmaI 및 AscI로 분해한 pSR6로 클로닝하여 pSR5 C25.2 LE를 수득하였다.
3. I-CeuI 및 PI-SceI 자리의 E1 기능적 결실 및 삽입:
플라스미드 pSR5 C25.2LE를 SnaBI + NdeI로 분해하였고; NdeI 자리를 Klenow로 채웠다. pBleuSK I-PI로부터의 EcoRV 단편을 연결하여 pSR5 C25.2 LE IP를 만들었다.
4. XbaI 자리(30071)로부터 바이러스 오른쪽 말단의 클로닝:
플라스미드 pSR5 C25.2 LE IP를 XbaI + EcoRV로 분해하였다. SAdV-25.2 DNA로부터 6559 bp 오른쪽 말단(XbaI 분해) 단편을 연결하여 pAdC12-LE-IP-RE를 만들었다.
5. 바이러스 중간 XbaI 단편(6037 - 30071)의 클로닝
플라스미드 pAdC12-LE-IP-RE를 XbaI로 분해하였다. SAdV-25.2 DNA로부터 24034 bp 단편을 연결하여 pAdC25.2 IP를 만들었다.
C. 표준 분자 생물학 기술을 사용하는 SAdV -26에 기초한 E1-결핍 플라스미드 분자 클론의 구성
SAdV-26 (아군 E)을 사용하는 E1 결핍 벡터를 설명한 바와 같이 제조하였다.
1. pSR5의 구성:
SwaI 측면에 위치하는 SmaI, ClaI, XbaI, SpeI, EcoRV 자리를 함유하는 링커를 EcoRI 및 NdeI에 의한 pBR322 절단에 클로닝한다.
Figure pat00009
를 어닐링하여 링커를 만들었다.
2. XbaI 자리 (6029) 에서 바이러스 왼쪽 말단의 클로닝
바이러스 DNA를 XbaI로 분해하고 6 kb 단편(왼쪽 및 오른쪽 말단)을 겔 정제하였고 SmaI 및 XbaI로 분해된 pSR5에 연결하였다.
3. I-CeuI 및 PI-SceI 자리의 E1 기능적 결실 및 삽입:
플라스미드 pSR5-C12-LE를 SnaBI + NdeI로 분해하였고; NdeI 자리를 Klenow로 채웠다. pBleuSK I-PI로부터의 EcoRV 단편을 연결하여 pAdC 12-LE-IP를 만들었다.
4. XbaI 자리(30158)로부터의 바이러스 오른쪽 말단의 클로닝:
플라스미드 pAdC12-LE-IP를 XbaI + EcoRV로 분해하였다. SAdV-26 DNA로부터의 6471 bp 오른쪽 말단 (XbaI 분해) 단편을 연결하여 PAdC12-LE-IP-RE를 만들었다.
5. 바이러스 중간 XbaI 단편(6029 - 30158)의 클로닝
플라스미드 pAdC12-LE-IP-RE를 XbaI + EcoRV로 분해하였다. SAdV-26 DNA로부터의 24129 bp 단편을 연결하여 pC26 IP를 만들었다.
D. SAdV-30의 벡터 구성
SAdV-30 (아군 E)을 사용하는 E1 결실 벡터를 설명한 바와 같이 제조하였다.
1. pSR3의 구성:
SwaI 자리 옆에 위치하는 SmaI, HindII,, EcoRV 자리를 함유하는 링커를 하기와 같이 EcoRI 및 NdeI에 의해 pBR322 절단으로 클로닝하였다.
올리고머 SEQ ID NO: 196: SV25 Top:
AATTATTTAAATCCCGGGTATCAAGCTTGATAGATATCATTTAAAT 및 SEQ ID NO: 197: SV25 Bot: TAATTTAAATGATATCTATCAAGCTTGATACCCGGGATTTAAAT를 함께 어닐링하여 링커를 만들었다.
2. HindIII 자리 (7146)에서 바이러스 왼쪽 말단의 클로닝
바이러스 DNA를 HindIII로 분해하였고 7146 bp 왼쪽 말단 단편을 SmaI 및 HindIII으로 분해하여 pSR3에 클로닝하여 pSR3 C30 LE를 수득하였다.
3. I-CeuI 및 PI-SceI 자리의 E1 기능적 결실 및 삽입:
플라스미드 pSR3C30 LE를 SnaBI + NdeI로 분해하였고; NdeI 자리를 Klenow으로 채웠다. pBleuSK I-PI로부터의 EcoRV 단편을 연결하여 pC30 LE IP를 만들었다. 내부 EcoRI 자리(왼쪽 ITR의 시작으로부터 위치 1040 bp에서)를 EcoRI로 pC30 LE IP를 분해함으로써 파괴하였고, Klenow 폴리머라아제로 돌출부분을 채우고 재-연결하였다. 이것으로 플라스미드 pC30 LE IP (EcoRI del)를 수득하였다.
4. HindIII 자리(33048)로부터 바이러스 오른쪽 말단의 클로닝:
플라스미드 pC30 LE IP (EcoRI del)를 HindIII + EcoRV로 분해하였다. SAdV-30 DNA로부터의 3574 bp 오른쪽 말단(HindIII 분해) 단편을 연결하여 PC30-LE-IP-RE를 만들었다.
5. EcoRI (33631) 단편에서 바이러스 중간 XbaI (6035)의 클로닝
플라스미드 pC30-LE-IP-RE를 XbaI + HindIII로 분해하였다. SAdV-30 DNA로부터의 27596 bp 단편을 연결하여 pC30 IP를 만들었다.
E. SAdV-37의 벡터 구성
SAdV-37 (아군 E)를 사용하는 E1 결실 벡터를 설명한 바와 같이 제조하였다.
1. pSR3의 구성:
SwaI 옆에 위치하는 SmaI, HindII, EcoRV 자리를 함유하는 링커를 하기와 같이 EcoRI 및 NdeI에 의한 pBR322 절단으로 클로닝하였다. 올리고머: SEQ ID NO: 196: SV25 Top: AATTATTTAAATCCCGGGTATCAAGCTTGATAGATATCATTTAAAT 및 SEQ ID NO: 197: SV25 Bot: TAATTTAAATGATATCTATCAAGCTTGATACCCGGGATTTAAAT를 함께 어닐링하여 링커를 만들었다.
2. HindIII 자리 (7147)에서 SAdV-37 바이러스 왼쪽 말단의 클로닝
바이러스 DNA를 HindIII로 분해하였고 7147 bp 왼쪽 말단 단편을 SmaI 및 HindIII으로 분해한 pSR3에 클로닝하여 pSR3 C37 LE를 수득하였다.
3. I-CeuI 및 PI-SceI 자리의 E1 기능적 결실 및 삽입:
플라스미드 pSR3 C37LE를 SnaBI 및 NdeI(Klenow를 채움) 사이에서 결실하여 E1a 및 대부분의 E1b 코딩 영역을 결실하였고; 그 자리에서 DNA 단편(pBleuSK I-PI로부터의 EcoRV 단편은 I-Ceul 및 PI-SceI에 대한 자리를 포함한다)을 연결하여 pSR3 C37 LE IP를 수득하였다.
4. HindIII 자리(33048)로부터의 SAdV-37 바이러스 오른쪽 말단의 클로닝.
플라스미드 pC37 LE IP를 HindIII + EcoRV로 분해하였다. SAdV-37 DNA로부터의 3575 bp 오른쪽 말단(HindIII 분해) 단편을 연결하여 pC37-LE-IP-RE를 만들었다.
5. SAdV-37 바이러스 HindIII (23522 - 33060) 단편의 클로닝
플라스미드 pC37-LE-IP-RE를 HindIII로 분해하였고 9538 bp 바이러스 HindIII 단편을 연결하였다. 정확한 방향성을 가지는 클론을 pC37 del Xba Pac로 불렀다.
6. SAdV-37 바이러스 XbaI (6036) PacI(30181) 단편의 클로닝
플라스미드 pC37 del Xba Pac를 XbaI 및 PacI로 분해하였고 24145 bp 바이러스 XbaI-PacI 단편을 연결하여 pC37IP를 수득하였다.
F. E1-결실 아데노바이러스 벡터의 구성
E1 결실 대신에 I-CeuI 및 PI-SceI 인식 자리를 포함하는 DNA 부분을 삽입하기 위해, 플라스미드 pBleuSK I-PI를 사용하였다. 플라스미드 pBleuSK I-PI는 pBluescript II SK(+) (Stratagene)의 EcoRV 자리에 삽입되는 654 bp 단편을 함유한다. 654 bp 절편은 희소-절단 제한 효소 I-CeuI 및 PI-SceI에 대한 인식 자리를 포함한다. E1 결실 대신에 I-CeuI 및 PI-SceI 인식 자리를 포함하는 DNA 부분을 삽입하기 위해, pBleuSK I-PI를 EcoRV로 분해하였고 654 bp 단편을 아데노바이러스 게놈 E1 결실의 위치에 연결하였다. 삽입한 DNA의 서열은 하기에서 EcoRV 인식 자리 옆에 위치됨을 나타낸다. I-CeuI 및 PI-SceI에 대한 인식 서열을 밑줄친다.
Figure pat00010
인플루엔자 바이러스 뉴클레오단백질을 발현시키는 E1-결실 아데노바이러스 벡터를 구성하기 위해서, H1N1 인플루엔자 A 바이러스 NP를 암호화하는 뉴클레오티드 서열(A/Puerto Rico/8/34/Mount Sinai, GenBank 등록번호 AF389119.1)은 최적화된 코돈이었고, 완전히 합성하였다(Celtek Genes, Nashville, TN). 인간 사이토메갈로바이러스 초기 프로모터, 합성 인트론(플라스미드 pCI (Promega, Madison, Wisconsin)로부터 얻음), 코돈 최적화 인플루엔자 A NP 코딩 서열 및 소 성장 호르몬 폴리아데닐화 신호로 구성되는 발현 카세트를 구성하였다. 플라스미드 pShuttle CMV PI FluA NP는 상기 기술된 발현 카세트를 포함하며, 이는 각각 희소-절단 제한 효소 I-CeuI 및 PI-SceI (New England Biolabs)에 대한 인식 자리 옆에 위치한다. E1-결핍 아데노바이러스 벡터의 분자 클론을 만들기 위해서, E1-결핍 아데노바이러스의 플라스미드 분자 클론을 본 실시예의 앞 부분에서 설명한 바와 같이 만들었고, 희소-절단 제한 효소 I-CeuI 및 PI-SceI에 대한 인식 자리를 E1 결실 대신 삽입하였다. E1-결실 아데노바이러스 플라스미드를 그 후 I-CeuI 및 PI-SceI로 분해하였고 발현 카세트(동일 효소에 의해 분해)를 연결하였다. 결과 아데노바이러스 플라스미드 분자 클론을 HEK 293 세포에 트랜스펙팅하여 재조합 아데노바이러스 벡터를 구하였다. 트랜스펙션 후 구제는 제한 효소 분해에 의해 플라스미드로부터 선형 아데노바이러스 게놈을 우선 방출함으로써 가능하게 됨을 발견하였다.
실시예 3 - 교차-중화 항체의 평가
야생형 SAdV-39, SAdV-25.2, SAdV-26, SAdV-30, SAdV-37 및 SAdV-38을 직접 면역 형광법에 의해 모니터링되는 감염 억제 중화 항체 분석을 사용하여 인간 아데노바이러스 5(아종 C) 및 침팬지 아데노바이러스 7(SAdV-24), 및 인간 풀링된 IgG와 비교하여 교차-중화 활성에 대해 평가하였다. 일반적 인간 집단이 노출된 다수의 항원에 대한 항체를 함유하기 때문에, 인간 풀링된 IgG[Hu Pooled IgG]를 상업적으로 구입하고, 면역타협 환자에서 투여를 위해 승인한다. 인간 풀링된 IgG에 대한 유인원 아데노바이러스에서 중화 항체의 존재 또는 부존재는 일반적 모집단에서 이들 아데노바이러스에 대한 항체의 보급의 반영이다.
분석을 하기와 같이 수행하였다. 앞서 HAdV-5 또는 SAdV-24로 주사한 토끼로부터의 혈청 샘플을 35분 동안 56℃에서 가열하여 불활성화하였다. 야생형 아데노바이러스(108 입자/웰)를 무혈청 둘베코 변형 이글 배지(DMEM)에서 희석하였고, 37℃에서 1시간 동안 DMEM에서 가열-불활성화된 혈청의 2-배 연속 희석으로 배양하였다. 이후에, 혈청-아데노바이러스 혼합물을 105 단일층 A549 세포와 함께 웰 내의 슬라이드에 첨가하였다. 1시간 후, 각 웰의 세포를 100 μl의 20% 소 태아혈청(FBS)-DMEM으로 보충하였고, 5% CO2로 37℃에서 22시간 동안 배양하였다. 다음에, 세포를 PBS로 2회 헹구고 DAPI로 염색하였고, 염소에 FITC로 표지된, 광범위하게 교차 반응성인 항체(Virostat)를 파라포름알데히드(4%, 30 분)에서 고정 및 0.2% Triton (4℃, 20 분)에서 침투 후 HAdV-5에 대해 길렀다. 감염의 수준을 현미경관찰 하에서 FITC 양성 세포의 수를 카운팅함으로써 결정하였다. NAB 타이터를 나이브(naive) 혈청 대조군과 비교하여 50% 이상으로써 아데노바이러스 감염을 억제한 가장 높은 혈청 희석으로서 기록한다. < 1/20의 타이터 값이 나타나면, 중화 항체 농도는 검출의 제한, 즉 1/20 이하이다.
Figure pat00011
이들 데이터는 일반 모집단에서 이들 아데노바이러스에 대해 최소한의 면역반응성이 있음을 나타낸다. 이들 데이터는 HAdV-5 및 SAdV-24와 교차-반응하지 않는 앞의 표에 있는 유인원 아데노바이러스가 아데노바이러스의 순차적 전달을 수반하는 요법, 예를 들어, 프라임-부스트 또는 암 치료법에 유용할 수 있음을 추가로 나타낸다.
실시예 4 - 사이토카인 유도
형질세포양 수지상세포를 인간 말초혈액 단핵구(PBMC)로부터 분리하였고, 96웰 플레이트로 배지에서 배양하였고 아데노바이러스로 감염시켰다. 48시간 후 세포를 스핀다운하고 상청액을 수집하였고 인터페론 α의 존재하에서 분석하였다.
더 구체적으로, PBMC를 펜실베니아 유니버시티에서 CFAR(Center For AIDS Research) 면역학 코어로부터 획득하였다. 3억개의 이들 세포를 그 후 키트와 함께 제공된 설명서에 따라서 Miltenyi Biotec제의 "인간 형질세포양 수지상세포 분리 키트"를 사용하여 형질세포양 수지상세포(pDCs)를 분리하기 위해 사용하였다. 이 키트를 사용하는 분리는 모든 다른 세포 종류를 제거하는 것을, 그러나 pDC는 PBMC로부터 제거하는 것을 기초로 하였다.
최종 세포 수는 보통 도너로부터 도너까지 다양하지만, 4십만 내지 7십만개의 세포의 범위에 있다. 따라서 발생된 데이터(하기 논의)는 다중 도너로부터의 세포의 분석에서 비롯된다. 그렇지만 놀랍게도, 인터페론 또는 다른 사이토카인 방출에 기초한 아군의 분리는 다양한 도너로부터 세포를 분리할 때조차 유지된다.
세포를 L-글루타민, 10% 소 태아 혈청(Mediatech), 1OmM 헤페스 완충제 용액(Invitrogen), 항생물질(페니실린, 스트렙토마이신 및 겐타마이신-Mediatech 제) 및 인간-인터류킨 3 (20ng/mL - R&D)으로 보충한 RPMI-1640 배지(Mediatech)에서 배양하였다. 야생형 아데노바이러스를 10,000 (세포 당 10,000개의 바이러스 입자, 106 세포/ml의 농도로)의 감염다중도(MOI)에서 세포에 직접 첨가하였다. 48 시간 후, 세포를 스핀 다운하였고, 상청액을 인터페론의 존재하에서 분석하였다. 사이토카인을 제조업자로부터 추천된 프로토콜을 사용하여 PBL 생물의학 연구소로부터 효소-결합면역흡착분석법(ELISA) 키트를 사용하여 분석하였다.
본 연구는 아군 C 아데노바이러스가 IFNα의 검출가능하지 않은 양을 만든다는 것을 나타내었다(본 분석은 1250 pg/mL의 검출 제한을 가진다). 반대로, 아군 E 아데노바이러스의 모든 시험 멤버는 IFNα를 생성하였고, 일반적으로 아군 B 아데노바이러스와 비교하여 상당히 우수한 IFNα를 생성하였다.
다양한 다른 사이토카인을 또한 아데노바이러스의 스크리닝에서 검출하였다. 그러나, 일반적으로, 아군 E 아데노바이러스는 아군 C 아데노바이러스보다 상당히 더 높은 수준의 IL-6, RANTES, MIP-1α, TNF-α, IL-8, 및 IP-10을 생성하였다. 아군 B 아데노바이러스는 또한 IFNα, IL-6, RANTES, 및 MIP1α의 유도에서 아군 C 아데노바이러스를 능가하였다.
상당한 세포 용혈이 이 연구에서 관찰되지 않았기 때문에, 이는 감염과 상관없이, 바이러스 복제의 어떤 상당한 양의 존재하에서 사이토카인이 아군 E 아데노바이러스와 세포를 접촉함으로써 생성된다는 것을 제안한다.
다른 연구에서(제시하지 않음), 세포를 중공 C7 캡시드 단백질(Ad 아군 E) 또는 UV-불활성 아데노바이러스 C7 바이러스 벡터(UV 불활성화는 교차-연결을 야기하며, 아데노바이러스 유전자 발현을 제거한다) 중 하나와 함께 상기 기술된 바와 같이 배양하였다. 이들 연구에서, 동일 또는 더 높은 수준의 IFNα가 무결함 C7과 비교하여 중공 캡시드와 불활성 바이러스 벡터 둘 다에 대해 관찰되었다.
본 발명자들은 PBMC, PBL, 및 수지상 세포와 같은 사이토카인-생성 세포 또는 케모킨-생성 세포를 아군 E 아데노바이러스의 멤버로부터 캡시드에 노출시키는 것은 사이토카인을 유도하고, 특히 IFNα, 또는 케모킨은 다른 아데노바이러스 아군에 의한 것보다 상당히 더 높은 양으로 유도된다는 것을 발견하였다. 따라서, 이 아군의 멤버는 배양물에서 알파 인터페론, 더 적은 양으로, 다수의 다른 사이토카인/케모킨을 유발하는데 유용하다.
재조합적으로 생성된 IFNα에 유리하게 되는 것으로 믿어지는 바와 같이, IFNα의 경우에, 생성 방법은 특히 바람직하다. 대조적으로, 본원에서 제공되는 방법은 더 넓은 작용의 스펙트럼을 초래하는 것으로 기대되는 천연 인간 IFNα의 다수의 서브타입을 생성하는 것으로 예상된다. 각 서브타입은 생물학적 활성을 사용하는 것으로 믿어진다. 추가로, 본원에서 제공되는 방법에 의해 생성되는 천연 인터페론은 환자의 자연적으로 생성된 인터페론과 면역학적으로 구별되지 않을 것임이 예상되며, 이에 의해 약물이, 보통 재조합적으로 생성된 인터페론에 대해 중화항체의 형성에 의해 야기되는 환자의 면역 체계에 의해 거부되는 위험을 감소시킨다.
아군 E 아데노바이러스에 의해 생성되는 다른 사이토카인은 인터류킨 (IL)-6, IL-8, IP-1O, 대식세포 염증 단백질-1 알파(MIP-1α), RANTES, 및 종양 괴사 인자 알파를 포함한다. 배양물로부터 사이토카인/케모킨을 정제하는 방법 및 이들 사이토카인/케모킨의 치료적 또는 보조적 사용은 본 문헌에서 기술되었다. 추가로, 상업적으로 이용가능한 컬럼 또는 키트는 본 발명에 따라서 제조되는 사이토카인/케모킨의 정제를 위해 사용될 수 있다. 본 발명을 사용하여 생성되는 사이토카인/케모킨은 다양한 증상에서 사용을 위해 제형으로 될 수 있다.
예를 들어, 본원에서 기술되는 사이토카인은, 인터페론 알파(IFNα), 종양 괴사 인자 알파(TNFα), IP-10 (인터페론 감마 유도성 단백질), 인터류킨-6 (IL-6), 및 IL-8을 포함한다. IFNα는 인플루엔자, 간염(예를 들어, B형 간염 및 C형 간염을 포함), 및 다양한 신생물, 예를 들어, 신장 (신장암), 흑색종, 악성 종양, 다발성 골수종, 유암종, 림프종 및 백혈병(예를 들어, 만성 골수성 백혈병 및 모양 세포성 백혈병)의 치료에 유용한 것으로 기술되었다. 본원에서 기술되는 바와 같이 생성된 IFNα 서브타입의 혼합물은 공지된 기술을 사용하여 정제될 수 있다. 예를 들어, 모노클로날 항체 및 컬럼 정제의 사용을 기술하는 WO 2006/085092 참조. 다른 기술은 본 문헌에서 설명하였다.
본원에서 설명하는 바와 같이 생성한 IFNα는 공지된 방법을 사용하여 정제될 수 있다. 예를 들어, 미국 특허 4,680,260호, 미국 특허 4,732,683호, 및 G. Allen, Biochem J., 207:397-408 (1982)을 참조. TNFα를 예를 들어, 건선 및 류마티스 관절염을 포함하는 자가면역 질환의 치료에 유용한 것으로 설명하였다. IP-10, 인터페론 감마 유도성 단백질은 혈관생성의 강력한 억제제로서 사용될 수 있고, 강력한 흉선-의존 항-종양 효과를 가지는 것으로 사용될 수 있다.
따라서, 또 다른 양태에서, 사이토카인을 생성하기에 적당한 조건하에서 수지상 세포 및 아군 E 아데노바이러스 캡시드를 함유하는 배양물을 배양함으로써 IFNα를 생성하는 방법이 제공된다.
한 구체예에서, 혈액은 건강한 도너(바람직하게는 인간)로부터 회수하고 말초혈액 백혈구 (PBL) 또는 말초혈액 단핵세포(PBMC)를 공지 기술을 사용하여 제조한다. 한 구체예에서, PBL을 본 발명의 방법에 따라서 사이토카인-생성 세포로서 사용한다. 다른 구체예에서, PBMC를 사이토카인-생성 세포로서 사용한다. 다른 구체예에서, 형질세포양 수지상세포를 공지 기술, 예를 들어, Miltenyi Biotec GmbH (독일)에 의한 상업적으로 이용가능한 키트 "인간 형질세포양 수지상세포 분리 키트"를 사용하여 PBL 또는 PBMC로부터 분리한다. 선택 세포를 적절한 배지 및 아데노바이러스 아군 E 캡시드 단백질과 함께 현탁으로 배양한다. 적절한 배지는 당업자에 의해 용이하게 결정될 수 있다. 그러나, 한 구체예에서, 배지는 RPMI-1640 배지이다. 또 다르게는, 다른 배지는 용이하게 선택될 수 있다.
세포를 적당한 용기, 예를 들어, 마이크로타이터 웰, 플라스크, 또는 더 큰 용기에서 배양할 수 있다. 한 구체예에서, 세포의 농도는 약 1백만 개 세포/mL 배양물 배지이다. 그러나, 다른 적당한 세포 농도는 당업자에 의해 용이하게 결정될 수 있다.
유리하게는, 본 발명은 프라이머로서 인터페론의 사용을 필요로 하지 않는다. 그러나, 원한다면, 배지는 세포 성장을 자극하기 위해서 적절한 사이토카인, IL-3을 포함할 수 있다. 한 적당한 농도는 약 20 ng/mL이다. 그러나, 다른 농도가 사용될 수 있다.
한 구체예에서, 아데노바이러스 캡시드 단백질은 세포를 함유하는 배양물에 포함된다. 아데노바이러스 캡시드 단백질은 본원에서 설명되는 어떤 형태(예를 들어, 중공 캡시드 입자, Ad 아군 E 캡시드 등을 포함하는 바이러스 입자)로 배양물에 전달될 수 있다. 전형적으로 캡시드 단백질은 적당한 담체, 예를 들어, 배양물 배지, 식염수 등에서 현택될 것이다.
적절하게는, 아데노바이러스 아군 E 캡시드는 세포 당 약 100 내지 100,000개의 아데노바이러스 아군 E 입자의 양으로 배양물에 첨가된다. 혼합물을 그 후, 예를 들어, 약 28℃ 내지 약 40℃의 범위, 약 35℃ 내지 약 37℃의 범위, 또는 약 37℃에서 배양한다.
전형적으로, 대략 12 내지 96 시간, 또는 약 48 시간 후, 세포를 스핀다운하고, 상청액을 수집한다. 적절하게는, 이것을 세포 용해를 피하는 조건하에서 수행하고, 이에 의해 상청액에서 세포 파편의 존재를 감소 또는 제거한다. 원심분리는 세포로부터 사이토카인의 분리를 허용하며, 이에 의해 천연 그대로의 분리된 사이토카인을 제공한다. 사이징(sizing) 컬럼, 다른 공지의 컬럼 및 방법은 아데노바이러스 및 아데노바이러스 캡시드 등으로부터 사이토카인의 추가 정제를 위해 이용가능하다.
이렇게 정제한 이들 사이토카인을 제형 및 다양한 용도를 위해 이용가능하다.
본원에서 설명한 바와 같이, 그리고 이론에 의해 뒷받침 없이, 아데노바이러스 아군 E의 면역 향상 및/또는 사이토카인 생성 능력은 아데노바이러스 입자의 전염력 또는 복제 능력에 관계없이 세포와 아데노바이러스 캡시드 사이의 접촉에 기초하여 나타난다. 따라서, 한 구체예에서, 중공 아데노바이러스 아군 E 입자(즉, 어떤 아데노바이러스 또는 유전자 이식 생성물을 발현시키는 그것에서 DNA 패키징을 가지지 않는 아데노바이러스 캡시드)는 세포에 전달된다. 다른 구체예에서, 비-전염성 야생성 아군 E 입자 또는 아데노바이러스 아군 E 캡시드(입자)에 패키징된 재조합 아데노바이러스 벡터가 사용된다. 이러한 바이러스 입자를 불활성화하는데 적절한 기술은 당업계에 공지되어 있으며 제한 없이, 예를 들어, UV 조사를 포함할 수 있다(발현을 방지하는 게놈의 DNA를 효과적으로 교차-연결).
상기 인용된 모든 문헌은 참고로써 본원에 포함된다. 수많은 변형 및 변경이 상기 확인된 설명의 범주에 포함되며 당업자에게 명백한 것으로 기대된다. 이러한 조성물 및 공정에 대한 변형 및 변경, 예로써 다른 미니유전자의 선택 또는 벡터 또는 면역 조절자의 선택 또는 투약량은 첨부되는 청구항의 범주 내인 것으로 믿어진다.
SEQUENCE LISTING <110> The Trustees of the University of Pennsylvania Roy, Soumitra Wilson, James M. Vandenberghe, Luc <120> Simian Subfamily E Adenoviruses SAdV-39, -25.2, -26, -30, -37, and -38 and Uses Thereof <130> UPN-U4623PCT <150> US 61/004,532 <151> 2007-11-28 <150> US 61/004,507 <151> 2007-11-28 <150> US 61/004,541 <151> 2007-11-28 <150> US 61/004,461 <151> 2007-11-28 <150> US 61/004,499 <151> 2007-11-28 <150> US 61/004,464 <151> 2007-11-28 <160> 200 <170> PatentIn version 3.5 <210> 1 <211> 36553 <212> DNA <213> Simian adenovirus 39 <220> <221> repeat_region <222> (1)..(126) <223> label=ITR <220> <221> CDS <222> (1905)..(3416) <223> label=Elb\55K <220> <221> CDS <222> (3504)..(3929) <223> label=pIX <220> <221> misc_feature <222> (3994)..(5615) <223> complement (3994..5324, 5603..5615) label=IVa2 <220> <221> misc_feature <222> (5097)..(13870) <223> complement (5097..8672, 13862..13870) label=pol <220> <221> misc_feature <222> (8474)..(13870) <223> complement (8474..10408, 13862..13870) label=pTP <220> <221> CDS <222> (10859)..(12037) <223> label=52K <220> <221> CDS <222> (12064)..(13833) <223> label=pIIIa <220> <221> CDS <222> (13915)..(15510) <223> label=penton <220> <221> CDS <222> (15517)..(16095) <223> label=pVII <220> <221> CDS <222> (16140)..(17180) <223> label=V <220> <221> CDS <222> (17208)..(17438) <223> label=pX <220> <221> CDS <222> (17473)..(18249) <223> label=pVI <220> <221> CDS <222> (18359)..(21178) <223> label=hexon <220> <221> CDS <222> (21202)..(21825) <223> label=protease <220> <221> misc_feature <222> (21910)..(23445) <223> complement label=DBP <220> <221> CDS <222> (23468)..(25870) <223> label=100K <220> <221> CDS <222> (26484)..(27164) <223> label=pVIII <220> <221> CDS <222> (27168)..(27485) <223> label=E3\12.5K <220> <221> CDS <222> (28056)..(28583) <223> label=E3\gp19K <220> <221> CDS <222> (28616)..(29233) <223> label=E3\CR1\beta <220> <221> CDS <222> (29249)..(29863) <223> label=E3\CR1\gamma <220> <221> CDS <222> (29881)..(30765) <223> label=E3\CR1\delta <220> <221> CDS <222> (30776)..(31048) <223> label=E3\RID\alpha <220> <221> CDS <222> (31057)..(31482) <223> label=E3\RID\beta <220> <221> CDS <222> (31997)..(33463) <223> label=fiber <220> <221> misc_feature <222> (33567)..(334708) <223> complement (33567..33815, 34529..34708) label=E4\orf6/7 <220> <221> misc_feature <222> (33815)..(34708) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34617)..(34979) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (34992)..(35342) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35342)..(35728) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35772)..(36143) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36428)..(36553) <223> complement label=ITR <400> 1 catcatcaat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcggt gattggcgga gagaagggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tccggagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgccc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggct gccgagcagg ctaatatgga ctctggctca gacagcgatt 840 cctctctcca taccccgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgatgt tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggagacgat tcgagctgcg gcgaaccagg gagtgaaagc tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagctggggg ggcagagggt gactgggtgc tgactggttt 1200 atttatgtat atgtttttta tgtgtaggtc ccgtctctga cgcagatgag acccccactt 1260 cagagtgcat ttcatcaccc ccagaaattg gcgaggaacc gcccgaagat attattcata 1320 gaccagttgc agtgagagtc accgggcgga gagcagctgt ggagagtttg gatgacttgc 1380 tacagggtgg ggatgaacct ttggacttgt gtacccggaa acgccccagg cactaagtgc 1440 cacacatgtg tgtttactta aggtgatgtc agtatttata gggtgtggag tgcaataaaa 1500 atatgtgttg actttaagtg cgtgttttat gactcagggg tggggactgt gggtatataa 1560 gcaggtgcag acctgtgtgg tcagttcaga gcaggactca tggagatctg gacggtcttg 1620 gaagactttc accagactag acagctgcta gagaactcat cggaggaagt ctcctacctg 1680 tggagattct gcttcggtgg gcctctagct aagctagtct atagggccaa acaggattat 1740 aaggatcaat ttgaggatat tttgagagag tgtcctggta tttttgactc tctcaacttg 1800 ggccatcagt ctcactttaa ccagagtatt ctgagagccc ttgacttttc tactcctggc 1860 agaactaccg ccgcggtagc cttttttgcc tttatccttg acaa atg gag tca aga 1916 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1964 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2012 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2060 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2108 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc 2156 Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser 70 75 80 ggt ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg 2204 Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 100 gtg ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag 2252 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 105 110 115 agg cat gag gag act agc cac aga acc gaa ctg act gtc agt ctg atg 2300 Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met 120 125 130 agc cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtg cag tcg cag 2348 Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln 135 140 145 ggg ata gat gag gtc tca gtg atg cat gag aaa tat tcc cta gaa caa 2396 Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln 150 155 160 gtc aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc 2444 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile 165 170 175 180 agg aat tat gcc aag ctg gct ctg aag cca gac aag aag tac aag att 2492 Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys Lys Tyr Lys Ile 185 190 195 acc aaa ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg 2540 Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly 200 205 210 gcc gag gtg gag atc agt acc cag gag agg gcg gcc ttc aga tgt tgt 2588 Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Ala Ala Phe Arg Cys Cys 215 220 225 atg atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt 2636 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe 230 235 240 atg aac acg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg 2684 Met Asn Thr Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met 245 250 255 260 gcc aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat 2732 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 265 270 275 aac atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agt 2780 Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser 280 285 290 ttt tca gcc aac tgg atg ggg atc gtg ggc agg acc aag agt gtg ctg 2828 Phe Ser Ala Asn Trp Met Gly Ile Val Gly Arg Thr Lys Ser Val Leu 295 300 305 tct gtg aag aaa tgc ttg ttc gag agg tgc cac ctg ggg gtg atg agc 2876 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 310 315 320 gag ggc gaa gcc aga atc cgc cac tgc gcc tct acc gag acg ggc tgc 2924 Glu Gly Glu Ala Arg Ile Arg His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 340 ttt gtg ctg tgc aag ggc aat gct aag atc aag cat aat atg atc tgt 2972 Phe Val Leu Cys Lys Gly Asn Ala Lys Ile Lys His Asn Met Ile Cys 345 350 355 gga gcc tcg gac gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg 3020 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 360 365 370 aac agc cat atg cta gcc acc gtg cat gtg gcc tcc cat gct cgc aag 3068 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Ala Arg Lys 375 380 385 ccc tgg ccc gag ttc gag cac aat gtc atg acc agg tgc aat atg cat 3116 Pro Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Met His 390 395 400 ctg ggg tcc cgc cga ggc atg ttc atg ccc tac cag tgc aac ctg aat 3164 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Leu Asn 405 410 415 420 tat gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg 3212 Tyr Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 425 430 435 acg ggg gtg ttt gac atg aat gtg gat gtg tgg aag att ctg aga tat 3260 Thr Gly Val Phe Asp Met Asn Val Asp Val Trp Lys Ile Leu Arg Tyr 440 445 450 gat gaa tcc aag acc agg tgc cga gcc tgc gag tgc gga ggg aag cat 3308 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 455 460 465 gcc agg ttc cag ccc gtg tgt gtg gat gtg acg gag gac ctg cga ccc 3356 Ala Arg Phe Gln Pro Val Cys Val Asp Val Thr Glu Asp Leu Arg Pro 470 475 480 gat cat ttg gtg ttg tcc tgc acc ggg acg gag ttc ggt tcc agc ggg 3404 Asp His Leu Val Leu Ser Cys Thr Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 500 gaa gaa tct gac tagagtgagt agtgttctgg ggcgggggag gacctgcatg 3456 Glu Glu Ser Asp agggccagaa tgactgaaat ctgtgctttt ctgtgtgttg cagcagc atg agc gga 3512 Met Ser Gly 505 agc ggc tcc ttt gag gga ggg gta ttc agc cct tat ctg acg ggg cgt 3560 Ser Gly Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg 510 515 520 ctc ccc tcc tgg gcg gga gtg cgt cag aat gtg atg gga tcc acg gtg 3608 Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser Thr Val 525 530 535 gac ggc cgg ccc gtg cag ccc gcg aac tct tca acc ctg acc tat gca 3656 Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala 540 545 550 555 acc ctg agc tct tcg tcg gtg gac gca gct gcc gcc gca gct gct gca 3704 Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala Ala Ala 560 565 570 tct gcc gcc agc gcc gtg cgc gga atg gcc atg ggc gcc ggc tac tac 3752 Ser Ala Ala Ser Ala Val Arg Gly Met Ala Met Gly Ala Gly Tyr Tyr 575 580 585 ggc act ctg gtg gcc aac tcg agt tcc acc aat aat ccc gcc agc ctg 3800 Gly Thr Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu 590 595 600 aac gag gag aag ctg ctg ctg ctg atg gca cag ctc gag gcc ttg acc 3848 Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala Leu Thr 605 610 615 cag cgc ctg ggc gag ctg acc cag cag gtg gct cag ctg cag gag cag 3896 Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln Glu Gln 620 625 630 635 acg cgg gct gcg gtt gcc acg gtg aaa tcc aaa taaaaaatga ttcaataaat 3949 Thr Arg Ala Ala Val Ala Thr Val Lys Ser Lys 640 645 aaacggagac ggttgttgat tttaacacag agtctgaatc tttatttgat ttttcgcgcg 4009 cggtaggccc tggaccaccg gtctcgatca ttgagcaccc ggtggatctt ttccaggacc 4069 cggtagaggt gggcttggat gttgaggtac atgggcatga gcccgtcccg ggggtggagg 4129 tagctccatt gcagggcctc gtgctcgggg gtggtgttgt aaatcaccca gtcatagcag 4189 gggcgcaggg cgtggtgttg cacaatatct ttgaggagga gactgatggc cacgggcagc 4249 cctttggtgt aggtgtttac aaatctgtta agctgggagg gatgcatgcg gggggagatg 4309 aggtgcatct tggcctggat cttgagattg gcgatgttgc cgcccagatc ccgcctgggg 4369 ttcatgttgt gcaggaccac cagcacggtg tatccggtgc acttggggaa tttatcatgc 4429 aacttggaag ggaaggcgtg aaagaatttg gcgacgccct tgtgcccgcc caggttttcc 4489 atgcactcat ccatgatgat ggcgatgggc ccgtgggcgg cggcctgggc aaagacgttt 4549 cgggggtcgg acacatcata gttgtggtcc tgggtgagat catcataggc cattttaatg 4609 aatttggggc ggagggtgcc cgattggggg acaaaggtac cctcgatccc gggggcgtag 4669 ttcccctcac agatctgcat ctcccaggct ttgagctcgg agggggggat catgtccacc 4729 tgcggggcga taaagaacac ggtttccggg gcgggggaga tgagctgggc cgaaagcaag 4789 ttgcggagca gctgtgactt gccgcagccg gtggggccgt agatgacccc gatgaccggc 4849 tgcaggtggt agttgaggga gagacagctg ccgtcctccc ggaggagggg ggccacctcg 4909 ttcatcatct cgcgcacatg catgttctcg cgcaccagtt ccgccaggag gcgctctccc 4969 cccagggata ggagctcctg gagcgaggcg aagtttttca gcggcttgag tccgtcggcc 5029 atgggcattt tggagagggt ctgttgcaag agttccaagc ggtcccagag ctcggtgatg 5089 tgctctacgg catctcgatc cagcagacct cctcgtttcg cgggttggga cgactgcggg 5149 agtagggcac cagacgatgg gcgtccagcg cagccagggt ccggtccttc cagggtcgca 5209 gcgtccgcgt cagggtggtc tccgtcacgg tgaaggggtg cgcgccgggc tgggcgcttg 5269 cgagggtgcg cttcaggctc atccggctgg tcgaaaaccg ctcccgatcg gcgccctgcg 5329 cgtcggccag gtagcaattg accatgagtt cgtagttgag cgcctcggcc gcgtggcctt 5389 tggcgcggag cttacctttg gaagtctgcc cgcaggcggg acagaggagg gacttgaggg 5449 cgtagagctt gggggcgagg aagacggact cgggggcgta ggcgtccgcg ccgcagtggg 5509 cgcagacggt ctcgcactcc acaagccagg tgaggtcggg ctggtcgggg tcaaaaacca 5569 gtttcccgcc gttctttttg atgcgtttct tacctttggt ctccatgagc tcgtgtcccc 5629 gctgggtgac aaagaggctg tccgtgtccc cgtagaccga ctttatgggc cggtcctcga 5689 gcggtgtgcc gcggtcctcc tcgtagagga accccgccca ctccgagacg aaagcccggg 5749 tccaggccag cacgaaggag gccacgtggg acgggtagcg gtcgttgtcc accagcgggt 5809 ccaccttttc cagggtatgc aaacacatgt ccccctcgtc cacatccagg aaggtgattg 5869 gcttgtaagt gtaggccacg tgaccggggg tcccagccgg gggggtataa aagggggcgg 5929 gcccctgctc gtcctcactg tcttccggat cgctgtccag gagcgccagc tgttggggta 5989 ggtattccct ctcgaaggcg ggcatgacct cggcactcag gttgtcagtt tctagaaacg 6049 aggaggattt gatattgacg gtgccgttgg agacgccttt catgagcccc tcgtccatct 6109 ggtcagaaaa gacgatcttt ttgttgtcga gcttggtggc gaaggagccg tagagggcgt 6169 tggagagcag cttggcgatg gagcgcatgg tctggttctt ttccttgtcg gcgcgctcct 6229 tggcggcgat gttgagctgc acgtactcgc gcgccacgca cttccattcg gggaatacgg 6289 tggtgagctc gtcgggcacg attctgaccc gccagccgcg gttgtgcagg gtgatgaggt 6349 ccacgctggt ggccacctcg ccgcgcaggg gctcgttggt ccagcagagg cgcccgccct 6409 tgcgcgagca gaaggggggc agcgggtcca gcatgagctc gtcggggggg tcggcgtcca 6469 cggtgaagat gccgggcagg agctcggggt cgaagtagct gatgcaggtg cccagatcgt 6529 ccagacttgc ttgccagtcg cgcacggcca gcgcgcgctc gtaggggctg aggggcgtgc 6589 cccagggcat ggggtgcgtg agcgcggagg cgtacatgcc gcagatgtcg tagacgtaga 6649 ggggctcctc gaggacgccg atgtaggtgg ggtagcagcg ccccccgcgg atgctggcgc 6709 gcacgtagtc gtacagctcg tgcgagggcg cgaggagccc cgtgccgaga ttggagcgct 6769 gcggcttttc ggcgcggtag acgatctggc ggaagatggc gtgggagttg gaggagatgg 6829 tgggcctctg gaagatgttg aagtgggcgt ggggcagtcc gaccgagtcc ctgatgaagt 6889 gggcgtagga gtcctgcagc ttggcgacga gctcggcggt gacgaggacg tccagggcgc 6949 agtagtcgag ggtctcttgg atgatgtcgt acttgagctg gcccttctgc ttccacagct 7009 cgcggttgag aaggaactct tcgcggtcct tccagtactc ttcgaggggg aacccgtcct 7069 gatcggcacg gtaagagccc accatgtaga actggttgac ggccttgtag gcgcagcagc 7129 ccttctccac ggggagggcg taagcttgcg cggccttgcg cagggaggtg tgggtgaggg 7189 cgaaggtgtc gcgcaccatg accttgagga actggtgctt gaagtcgagg tcgtcgcagc 7249 cgccctgctc ccagagctgg aagtccgtgc gcttcttgta ggcggggttg ggcaaagcga 7309 aagtaacatc gttgaagagg atcttgcccg cgcggggcat gaagttgcga gtgatgcgga 7369 aaggctgggg cacatcggcc cggttgttga tgacctgggc ggcgaggacg atctcgtcga 7429 agccgttgat gttgtgcccg acgatgtaga gttccacgaa tcgcgggcgg cccttgacgt 7489 ggggcagctt cttgagctcg tcgtaggtga gctcggcggg gtcgctgagc ccgtgctgct 7549 cgagggccca gtcggcgacg tgggggttgg cgcggaggaa ggaagtccag agatccacag 7609 ccagggcggt ctgcaagcgg tcccggtact gacggaactg ctggcccacg gccatttttt 7669 cgggggtgac gcagtagaag gtgcgggggt cgccgtgcca gcggtcccac ttgagctgga 7729 gggcgaggtc gtgggcgagc tcgacgagcg gcgggtcccc ggagagtttc atgaccagca 7789 tgaaggggac gagctgcttg ccgaaggacc ccatccaggt gtaggtttcc acatcgtagg 7849 tgaggaagag cctttcggtg cgaggatgcg agccgatggg gaagaactgg atctcctgcc 7909 accagttgga ggaatggctg ttgatgtgat ggaagtagaa atgccgacgg cgcgccgagc 7969 actcgtgctt gtgtttatac aagcgtccgc agtgctcgca acgctgcacg ggatgcacgt 8029 gctgcacgag ctgtacctgg gttcctttga cgaggaattt cagtgggcag tggagcgctg 8089 gcggctgcat ctggtgctgt actacgtcct ggccatcggc gtggccatcg tctgcctcga 8149 tggtggtcat gctgacgagc ccgcgcggga ggcaggtcca gacctcggct cggacgggtc 8209 ggagagcgag gacgagggcg cgcaggccgg agctgtccag ggtcctgaga cgctgcggag 8269 tcaggtcagt gggcagcggc ggcgcgcggt tgacttgcag gagcttttcc agggcgcgcg 8329 ggaggtccag atggtacttg atctccacgg cgccgttggt ggcgacgtcc acggcttgca 8389 gggtgccgtg cccctggggc gccaccaccg tgccccgttt cttcttgggc gctggcggcg 8449 ttggcgctgc ttccatgtcg gtcagaagcg gcggcgagga cgcgcgccgg gcggcagggg 8509 cggctcgggg cccggaggca ggggcggcag gggcacgtcg gcgccgcgcg cgggcaggtt 8569 ctggtactgc gcccggagaa gactggcgtg agcgacgacg cgacggttga cgtcctggat 8629 ctgacgcctc tgggtgaagg ccacgggacc cgtgagtttg aacctgaaag agagttcgac 8689 agaatcaatc tcggtatcgt tgacggcggc ctgccgcagg atctcttgca cgtcgcccga 8749 gttgtcctgg taggcgatct cggtcatgaa ctgctcgatc tcctcctcct gaaggtctcc 8809 gcggccggcg cgctcgacgg tggccgcgag gtcgttggag atgcggccca tgagctgcga 8869 gaaggcgttc atgccggcct cgttccagac gcggctgtag accacggctc cgtcggggtc 8929 gcgcgcgcgc atgaccacct gggcgaggtt gagctcgacg tggcgcgtga agaccgcgta 8989 gttgcagagg cgctggtaga ggtagttgag cgtggtggcg atgtgctcgg tgacgaagaa 9049 gtacatgatc cagcggcgga gcggcatctc gctgacgtcg cccagggctt ccaagcgctc 9109 catggcctcg tagaagtcca cggcgaagtt gaaaaactgg gagttgcgcg ccgagacggt 9169 caactcctcc tccagaagac ggatgagctc ggcgatggtg gcgcgcacct cgcgctcgaa 9229 ggccccgggg ggctcctctt cttccatctc ctcctcctct tcctcctcca ctaacatctc 9289 ttctacttcc tcctcaggag gcggcggcgg gggaggggcc ctgcgtcgcc ggcggcgcac 9349 gggcagacgg tcgatgaagc gctcgatggt ctccccgcgc cggcgacgca tggtctcggt 9409 gacggcgcgc ccgtcctcgc ggggccgcag cgtgaagacg ccgccgcgca tctccaggtg 9469 gccgccgggg gggcctccgt tgggcaggga gagggcgctg acgatgcatc ttatcaattg 9529 gcccgtaggg actccgcgca aggacctgag cgtctcgaga tccacgggat ccgaaaaccg 9589 ctgaacgaag gcttcgagcc agtcgcagtc gcaaggtagg ctgagcacgg tttcttctgg 9649 cgggtctggc tggggagcgg ggcgggcgat gctgctggtg atgaagttga aataggcggt 9709 tctgagacgg cggatggtgg cgaggagcac caggtccttg ggcccggctt gctggatgcg 9769 cagacggtcg gccatgcccc aggcgtggtc ctgacacctg gcgaggtcct tgtagtagtc 9829 ctgcatgagc cgctccacgg gcacctcctc ctcgcccgcg cggccgtgca tgcgcgtgag 9889 cccgaacccg cgctgcggct ggacgagcgc caggtcggcg acgacgcgct cggcgaggat 9949 ggcctgctgg atctgggtga gggtggtctg gaagtcgtcg aagtcgacga agcggtggta 10009 ggctccggtg ttgatggtgt aggagcagtt ggccatgacg gaccagttga cggtctggtg 10069 gccggggcgc acgagctcgt ggtacttgag gcgcgagtag gcgcgcgtgt cgaagatgta 10129 gtcgttgcag gtgcgcacga ggtactggta tccgacgagg aagtgcggcg gcggctggcg 10189 gtagagcggc catcgctcgg tggcgggggc gccgggcgcg aggtcctcga gcatgaggcg 10249 gtggtagccg tagatgtacc tggacatcca ggtgatgccg gcggcggtgg tggaggcgcg 10309 cgggaactcg cggacgcggt tccagatgtt gcgcagcggc aggaagtagt tcatggtggc 10369 cgcggtctgg cccgtgaggc gcgcgcagtc gtggatgctc tagacatacg ggcaaaaacg 10429 aaagcggtca gcggctcgac tccgtggcct ggaggctaag cgaacgggtt gggctgcgcg 10489 tgtaccccgg ttcgaatctc gaatcaggct ggagccgcag ctaacgtggt actggcactc 10549 ccgtctcgac ccaagcctgc taacgaaacc tccaggatac ggaggcgggt cgttttttgg 10609 ccttggccgc tggtcatgaa aaactagtaa gcgcggaaag cggccgtccg cgatggctcg 10669 ctgccgtagt ctggagaaag aatcgccagg gttgcgttgc ggtgtgcccc ggttcgagcc 10729 tcagcgctcg gcgccggccg gattccgcgg ctaacgtggg cgtggctgcc ccgtcgtttc 10789 caagacccct tagccagccg acttctccag ttacggagcg agcccctctt tttcttgtgt 10849 ttttgccag atg cat ccc gta ctg cgg cag atg cgc ccc cac cct cca cca 10900 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro 650 655 660 caa ccg ccc cta ccg ccg cag cag cag caa cag ccg gcg ctt ctg ccc 10948 Gln Pro Pro Leu Pro Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro 665 670 675 ccg ccc cag cag cag cag cag cca gcc act acc gcg gcg gcc gcc gtg 10996 Pro Pro Gln Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val 680 685 690 agc gga gcc ggc gtt cag tat gac ctg gcc ttg gaa gag ggc gag ggg 11044 Ser Gly Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly 695 700 705 ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc gtg cag 11092 Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln 710 715 720 atg aaa agg gac gct cgc gag gcc tac gtg ccc aag cag aac ctg ttc 11140 Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe 725 730 735 740 aga gac agg agc ggc gag gag ccc gag gag atg cgc gcg gcc cgg ttc 11188 Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe 745 750 755 cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga aag agg gtg ctg 11236 His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu 760 765 770 agg gac gag gat ttc gag gcg gac gag ctg acg ggg atc agc ccc gcg 11284 Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala 775 780 785 cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg tac gag cag acc 11332 Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr 790 795 800 gtg aag gag gag agc aac ttc caa aaa tcc ttc aac aac cac gtg cgc 11380 Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg 805 810 815 820 acc ctg atc gcg cgc gag gag gtg acc ctg ggc ctg atg cac ctg tgg 11428 Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp 825 830 835 gac ctg ctg gag gcc atc gtg cag aac ccc acc agc aag ccg ctg acg 11476 Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr 840 845 850 gcg cag ctg ttc ctg gtg gtg cag cat agt cgg gac aac gag gcg ttc 11524 Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe 855 860 865 agg gag gcg ctg ctg aat atc acc gag ccc gag ggc cgc tgg ctc ctg 11572 Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu 870 875 880 gac ctg gtg aac att ctg cag agc atc gtg gtg cag gag cgc ggg ctg 11620 Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu 885 890 895 900 ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg gtg ctg agt ctg 11668 Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu 905 910 915 ggc aag tac tac gct agg aag atc tac aag acc ccg tac gtg ccc ata 11716 Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile 920 925 930 gac aag gag gtg aag atc gac ggg ttt tac atg cgc atg acc ctg aaa 11764 Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys 935 940 945 gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc aac gac agg atg 11812 Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met 950 955 960 cac cgc gcg gtg agc gcc agc agg cgg cgc gag ctg agc gac cag gag 11860 His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu 965 970 975 980 ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc ggg acc gag ggg 11908 Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly 985 990 995 gag agc tac ttt gac atg ggc gcg gac ctg cac tgg cag ccc agc 11953 Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser 1000 1005 1010 cgc cgg gcc ttg gaa gcg gcg gca gga ccc tac gta gaa gag gtg 11998 Arg Arg Ala Leu Glu Ala Ala Ala Gly Pro Tyr Val Glu Glu Val 1015 1020 1025 gac gat gag gtg gac gag gag ggc gag tac ctg gaa gac tgatggcgcg 12047 Asp Asp Glu Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 1030 1035 accgtatttt tgctag atg caa caa cag cca cct cct gat ccc gcg atg 12096 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met 1040 1045 1050 cgg gcg gcg ctg cag agc cag ccg tcc ggc att aac tcc tcg gac 12141 Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp 1055 1060 1065 gat tgg acc cag gcc atg caa cgc atc atg gcg ctg acg acc cgc 12186 Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr Arg 1070 1075 1080 aac ccc gaa gcc ttt aga cag cag ccc cag gcc aac cgg ctc tcg 12231 Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser 1085 1090 1095 gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcc aac ccc acg cac 12276 Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His 1100 1105 1110 gag aag gtc ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc 12321 Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala 1115 1120 1125 atc cgc ggc gac gag gcc ggc ctg gtg tac aac gcg ctg ctg gag 12366 Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu 1130 1135 1140 cgc gtg gcc cgc tac aac agc acc aac gtg cag acc aac ctg gac 12411 Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp 1145 1150 1155 cgc atg gtg acc gac gtg cgc gag gcc gtg gcc cag cgc gag cgg 12456 Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln Arg Glu Arg 1160 1165 1170 ttc cac cgc gag tcc aac ctg gga tcc ctg gtg gcg ctg aac gcc 12501 Phe His Arg Glu Ser Asn Leu Gly Ser Leu Val Ala Leu Asn Ala 1175 1180 1185 ttc ctc agc acc cag ccc gcc aac gtg ccc cgg ggc cag gag gac 12546 Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp 1190 1195 1200 tac acc aac ttc atc agc gcc ctg cgc ctg atg gtg acc gag gtg 12591 Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 1205 1210 1215 ccc cag agc gag gtg tac cag tcc ggg ccg gac tac ttc ttc cag 12636 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 1220 1225 1230 acc agt cgc cag ggc ttg cag acc gtg aac ctg agc cag gcg ttc 12681 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe 1235 1240 1245 aag aac ttg cag ggc ctg tgg ggc gtg cag gcc ccg gtc ggg gac 12726 Lys Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp 1250 1255 1260 cgc gcg acg gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg 12771 Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu 1265 1270 1275 ctg ctg ctg gtg gcc ccc ttc acg gac agc ggc agc atc aac cgc 12816 Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg 1280 1285 1290 aac tcg tac ctg ggc tac ctg att aac ctg tac cgc gag gcc atc 12861 Asn Ser Tyr Leu Gly Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile 1295 1300 1305 ggc cag gcg cac gtg gac gag cag acc tac cag gag atc acc cac 12906 Gly Gln Ala His Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr His 1310 1315 1320 gtg agc cgc gcc ctg ggc cag gac gac ccg ggc aat ctg gaa gcc 12951 Val Ser Arg Ala Leu Gly Gln Asp Asp Pro Gly Asn Leu Glu Ala 1325 1330 1335 acc ctg aac ttt ttg ctg acc aac cgg tcg cag aaa atc ccg ccc 12996 Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln Lys Ile Pro Pro 1340 1345 1350 cag tac gcc ctc agc gcc gag gag gag cgc att ctg cga tac gtg 13041 Gln Tyr Ala Leu Ser Ala Glu Glu Glu Arg Ile Leu Arg Tyr Val 1355 1360 1365 cag cag agc gtg ggc ctg ttc ctg atg cag gag ggg gcc acc ccc 13086 Gln Gln Ser Val Gly Leu Phe Leu Met Gln Glu Gly Ala Thr Pro 1370 1375 1380 agc gcc gcg ctc gac atg acc gcg cgc aac atg gag ccc agc atg 13131 Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met Glu Pro Ser Met 1385 1390 1395 tac gcc agc aac cgc ccg ttc atc aat aaa ctg atg gac tac ttg 13176 Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met Asp Tyr Leu 1400 1405 1410 cat cgg gcg gcc gcc atg aac tcg gac tat ttc acc aac gcc atc 13221 His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn Ala Ile 1415 1420 1425 ctg aat ccc cac tgg ctc ccg ccg ccg ggg ttt tac acg ggc gag 13266 Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly Glu 1430 1435 1440 tac gac atg ccc gac ccc aat gac ggg ttc ctg tgg gac gat gtg 13311 Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 1445 1450 1455 gac agc agc gtg ttc tcc ccc cga ccg ggt gct aac gag cgc ccc 13356 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro 1460 1465 1470 ttg tgg aag aag gaa ggc agc gac cga cgc ccg tcc tcg gcg ctg 13401 Leu Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu 1475 1480 1485 tcc ggc cgc gag ggt gct gcc gcg gcg gtg ccc gag gcc gcc agt 13446 Ser Gly Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser 1490 1495 1500 cct ttc ccg agc ttg ccc ttc tcg ctg aac agt att cgc agc agc 13491 Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser 1505 1510 1515 gag ctg ggc agg atc acg cgc ccg cgt ttg ctg ggc gag gag gag 13536 Glu Leu Gly Arg Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu 1520 1525 1530 tac ttg aat gac tcg ctg ttg aga ccc gag cgg gag aag aac ttc 13581 Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe 1535 1540 1545 ccc aat aac ggg ata gag agc ctg gtg gac aag atg agc cgc tgg 13626 Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser Arg Trp 1550 1555 1560 aag acg tac gcg cag gag cac agg gac gat ccg tcg cag ggg gcc 13671 Lys Thr Tyr Ala Gln Glu His Arg Asp Asp Pro Ser Gln Gly Ala 1565 1570 1575 acg agc cgg ggc agc gcc gcc cgt aaa cgc cgg tgg cac gac agg 13716 Thr Ser Arg Gly Ser Ala Ala Arg Lys Arg Arg Trp His Asp Arg 1580 1585 1590 cag cgg gga ctg atg tgg gac gat gag gat tcc gcc gac gac agc 13761 Gln Arg Gly Leu Met Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser 1595 1600 1605 agc gtg ttg gac ttg ggt ggg agt ggt ggt aac ccg ttc gct cac 13806 Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Asn Pro Phe Ala His 1610 1615 1620 ctg cgc ccc cgc atc ggg cgc atg atg taagaaaccg aaaataaatg 13853 Leu Arg Pro Arg Ile Gly Arg Met Met 1625 atactcacca aggccatggc gaccagcgtg cgttcgtttc ttctctgttg ttgtatctag 13913 t atg atg agg cgt gcg tac ccg gag ggt cct cct ccc tcg tac gag 13959 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu 1630 1635 1640 agc gtg atg cag cag gcg atg gcg gcg gcg gcg atg cag ccc ccg 14004 Ser Val Met Gln Gln Ala Met Ala Ala Ala Ala Met Gln Pro Pro 1645 1650 1655 ctg gag gct cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag 14049 Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu 1660 1665 1670 ggg cgg aac agc att cgt tac tcg gag ctg gca ccc ttg tac gat 14094 Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp 1675 1680 1685 acc acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac atc gcc 14139 Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala 1690 1695 1700 tcg ctg aac tac cag aac gac cac agc aac ttc ctg acc acc gtg 14184 Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val 1705 1710 1715 gtg cag aac aat gac ttc acc ccc acg gag gcc agc acc cag acc 14229 Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr 1720 1725 1730 atc aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc 14274 Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr 1735 1740 1745 atc atg cac acc aac atg ccc aac gtg aac gag ttc atg tac agc 14319 Ile Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser 1750 1755 1760 aac aag ttc aag gcg cgg gtc atg gtc tcc cgc aag acc ccc aac 14364 Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn 1765 1770 1775 ggg gtg gga gag gat tat gat ggt agt cag gat gag ctg aaa tac 14409 Gly Val Gly Glu Asp Tyr Asp Gly Ser Gln Asp Glu Leu Lys Tyr 1780 1785 1790 gaa tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc tcg gtg acc 14454 Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val Thr 1795 1800 1805 atg acc atc gac ctg atg aac aac gcc atc atc gac aat tac ttg 14499 Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu 1810 1815 1820 gcg gtg ggg cgg cag aac ggg gtc ctg gag agc gat atc ggc gtg 14544 Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 1825 1830 1835 aag ttc gac act agg aac ttc agg ctg ggg tgg gac ccc gtg acc 14589 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr 1840 1845 1850 gag ctg gtc atg ccc ggg gtg tac acc aac gag gcc ttc cat ccc 14634 Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 1855 1860 1865 gat att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc acc gag agc 14679 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 1870 1875 1880 cgc ctc agc aac ctg ctg ggc att cgc aag agg cag cca ttc cag 14724 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln 1885 1890 1895 gag ggt ttc cag atc atg tac gag gat ctg gag ggg ggc aac atc 14769 Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile 1900 1905 1910 ccc gca ctc ctg gat gtc gac gcc tat gag aaa agc aag gag gaa 14814 Pro Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu 1915 1920 1925 gca gca gct gag gca acc gca gcc gta gcc acc gcc tct acc gag 14859 Ala Ala Ala Glu Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu 1930 1935 1940 gtc agg ggc gat aat ttt gcc agc cct gca gca gtg gca gcg gcc 14904 Val Arg Gly Asp Asn Phe Ala Ser Pro Ala Ala Val Ala Ala Ala 1945 1950 1955 gag gcg gct gaa acc gaa agt aag ata gtc att cag ccg gtg gag 14949 Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln Pro Val Glu 1960 1965 1970 aag gat agc aag aac agg agc tac aac gta cta ccg gac aag ata 14994 Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu Pro Asp Lys Ile 1975 1980 1985 aac acc gcc tac cgc agc tgg tac ctg gcc tac aac tat ggc gac 15039 Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp 1990 1995 2000 ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg gac 15084 Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 2005 2010 2015 gtc acc tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac atg 15129 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met 2020 2025 2030 atg caa gac ccg gtc acc ttc cgc tcc acg cgt caa gtt agc aac 15174 Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn 2035 2040 2045 tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag agc 15219 Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser 2050 2055 2060 ttc ttc aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc ttc 15264 Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe 2065 2070 2075 acc tcg ctc acg cac gtc ttc aac cgc ttt ccc gag aac cag atc 15309 Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile 2080 2085 2090 ctc gtc cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa aac 15354 Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 2095 2100 2105 gtt cct gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc agt 15399 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser 2110 2115 2120 atc cgg gga gtc cag cgc gtg acc gtt act gac gcc aga cgc cgc 15444 Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg 2125 2130 2135 acc tgc ccc tac gtc tac aag gcc ctg ggc ata gtc gcg ccg cgc 15489 Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg 2140 2145 2150 gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg ccc 15537 Val Leu Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser Pro 2155 2160 2165 agt aat aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg tac 15582 Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr 2170 2175 2180 gga ggc gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg cgc 15627 Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val Arg 2185 2190 2195 ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc cgc gtg cgc 15672 Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val Arg 2200 2205 2210 tcg cgc acc acc gtc gac gac gtg atc gac cag gtg gtg gcc gac 15717 Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala Asp 2215 2220 2225 gcg cgc aac tac acg ccc gcc gcc gcg ccc gcc tcc acc gtg gac 15762 Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr Val Asp 2230 2235 2240 gcc gtc atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc cgc 15807 Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala Arg 2245 2250 2255 gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc acc 15852 Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 2260 2265 2270 ccc gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg cgc 15897 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg 2275 2280 2285 acg gga cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gct tca 15942 Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser 2290 2295 2300 ggc gcc agc gcc ggc agg acc cgg aga cgc gcg gcc acg gcg gcg 15987 Gly Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala 2305 2310 2315 gca gcg gcc atc gcc agc atg tcc cgc ccg cgg cga ggg aac gtg 16032 Ala Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val 2320 2325 2330 tac tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc 16077 Tyr Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg 2335 2340 2345 acc cgc ccc cct cgc act tgaagatgtt cacttcgcga tgttgatgtg 16125 Thr Arg Pro Pro Arg Thr 2350 tcccagcggc gagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc 16172 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu 2355 2360 2365 cag gtc atc gcg cct gag atc tac ggc ccc gcg gcg gcg gtg aag 16217 Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys 2370 2375 2380 gag gaa aga aag ccc cgc aaa ctg aag cgg gtc aaa aag gac aaa 16262 Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg Val Lys Lys Asp Lys 2385 2390 2395 aag gag gag gaa gat gac gga ctg gtg gag ttt gtg cgc gag ttc 16307 Lys Glu Glu Glu Asp Asp Gly Leu Val Glu Phe Val Arg Glu Phe 2400 2405 2410 gcc ccc cgg cgg cgc gtg cag tgg cgc ggg cgg aag gtg cag ccg 16352 Ala Pro Arg Arg Arg Val Gln Trp Arg Gly Arg Lys Val Gln Pro 2415 2420 2425 gtg ctg aga ccc ggc acc acc gtg gtc ttc acg ccc ggc gag cgc 16397 Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg 2430 2435 2440 tcc ggc acc gct tcc aag cgc tcc tac gac gag gtg tac ggg gat 16442 Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp 2445 2450 2455 gat gat att ctg gag cag gcg gcc gag cgc ctg ggc gag ttt gct 16487 Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala 2460 2465 2470 tac ggc aag cgc agc cgc tcc gcg ctg aag gaa gag gcg gtg tcc 16532 Tyr Gly Lys Arg Ser Arg Ser Ala Leu Lys Glu Glu Ala Val Ser 2475 2480 2485 atc ccg ctg gac cac ggc aac ccc acg ccg agc ctc aag ccc gtg 16577 Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val 2490 2495 2500 acc ctg cag cag gtg ctg ccg agc gcg gcg ccg cga agg ggg ttc 16622 Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe 2505 2510 2515 aag cgc gag ggc gag gat ctg tat ccc acc atg cag ctg atg gtg 16667 Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val 2520 2525 2530 ccc aaa cgc cag aag ctg gaa gac gtg ctg gaa acc atg aag gtg 16712 Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val 2535 2540 2545 gac ccg gac gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag 16757 Asp Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 2550 2555 2560 gtg gcc ccg ggt ctg ggc gtg cag acc gtg gac atc aag atc ccc 16802 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro 2565 2570 2575 acg gag ccc atg gaa acg cag acc gag ccc atg atc aag ccc agt 16847 Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Met Ile Lys Pro Ser 2580 2585 2590 acc agc acc atg gag gtg cag acg gat ccc tgg atg cca gcc gcc 16892 Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala 2595 2600 2605 ccc acc agc agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc 16937 Pro Thr Ser Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser 2610 2615 2620 ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc atc ccc acg 16982 Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr 2625 2630 2635 ccg ggc tac cgc ggc acg cgc ttc tac cgc ggt cat aca acc agc 17027 Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Thr Ser 2640 2645 2650 tcc cgc cgc cgc aag acc acc acc cgc cgc cgt cgt cgc agc cgc 17072 Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Ser Arg 2655 2660 2665 cgc agc agc acc gcg act tcc gcc gcc gcc ctg gtg cgg aga gtg 17117 Arg Ser Ser Thr Ala Thr Ser Ala Ala Ala Leu Val Arg Arg Val 2670 2675 2680 tac cgc agc ggg cgc gag cct ctg acc ctg ccg cgc gcg cgc tac 17162 Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro Arg Ala Arg Tyr 2685 2690 2695 cac ccg agc atc gcc att taactctgcc gtcgcctcct tgcagat atg gcc 17213 His Pro Ser Ile Ala Ile Met Ala 2700 ctc aca tgc cgc ctc cgc gtc ccc att acg ggc tac cga gga aga 17258 Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg 2705 2710 2715 aag ccg cgc cgt aga agg ctg gcg ggg aac ggg atg cgt cgc cac 17303 Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 2720 2725 2730 cac cac cgg cgg cgg cgc gcc atc agc aag cgg ttg ggg gga ggc 17348 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly 2735 2740 2745 ttc ctg ccc gcg ctg atc ccc atc atc gcc gcg gcg atc ggg gcg 17393 Phe Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala 2750 2755 2760 atc ccc ggc att gct tcc gtg gcg gtg cag gcc tct cag cgc cac 17438 Ile Pro Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2765 2770 2775 tgagacacac ttggaaacat cttgtaataa acca atg gac tct gac gct cct 17490 Met Asp Ser Asp Ala Pro 2780 ggt cct gtg atg tgt ttt cgt aga cag atg gaa gac atc aat ttt 17535 Gly Pro Val Met Cys Phe Arg Arg Gln Met Glu Asp Ile Asn Phe 2785 2790 2795 tcg tcc ctg gct ccg cga cac ggc acg cgg ccg ttc atg ggc acc 17580 Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr 2800 2805 2810 tgg agc gac atc ggc acc agc caa ctg aac ggg ggc gcc ttc aat 17625 Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn 2815 2820 2825 tgg agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctt 17670 Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu 2830 2835 2840 aaa acc tat ggc agc aag gcg tgg aac agc acc aca ggg cag gcg 17715 Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala 2845 2850 2855 ctg agg gat aag ctg aaa gag cag aac ttc cag cag aag gtg gtc 17760 Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 2860 2865 2870 gat ggg ctc gcc tcg ggc atc aac ggg gtg gtg gac ctg gcc aac 17805 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 2875 2880 2885 cag gcc gtg cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg 17850 Gln Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro 2890 2895 2900 ccc gcc ggc tcc gtg gag atg ccg cag gtg gag gag gag ctg cct 17895 Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro 2905 2910 2915 ccc ctg gac aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag 17940 Pro Leu Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu 2920 2925 2930 gag acg ctg ctg acg cac acg gac gag ccg ccc ccg tac gag gag 17985 Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu 2935 2940 2945 gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc atc gcg ccc ctg 18030 Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu 2950 2955 2960 gcc acc ggg gtg ctg aaa ccc gaa agt aat aag ccc gcg acc ctg 18075 Ala Thr Gly Val Leu Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu 2965 2970 2975 gac ttg cct cct ccc cag cct tct cgc ccc tcc aca gtg gct aag 18120 Asp Leu Pro Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys 2980 2985 2990 ccc ctg ccg ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc acc 18165 Pro Leu Pro Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Thr 2995 3000 3005 gcc cgc cct cat gcg aac tgg cag agc act ctg aac agc atc gtg 18210 Ala Arg Pro His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val 3010 3015 3020 ggt ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc 18259 Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 3025 3030 3035 gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc cgctgtccac 18319 cagaaggagg agtgaagagg cgcgtcgccg agttgcaag atg gcc acc cca tcg 18373 Met Ala Thr Pro Ser 3040 atg ctg ccc cag tgg gcg tac ata cac atc gcc gga cag gac gct 18418 Met Leu Pro Gln Trp Ala Tyr Ile His Ile Ala Gly Gln Asp Ala 3045 3050 3055 tcg gag tac ctg agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca 18463 Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr 3060 3065 3070 gac acc tac ttc agt ctg ggg aac aag ttt agg aac ccc acg gtg 18508 Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val 3075 3080 3085 gcg ccc acg cac gat gtg acc acc gac cgc agc cag cgg ctg acg 18553 Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr 3090 3095 3100 ctg cgc ttc gtg ccc gtg gac cgc gag gac aac acc tac tcg tac 18598 Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 3105 3110 3115 aaa gtg cgc tac acg ctg gcc gtg ggc gac aac cgc gtg ctg gac 18643 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp 3120 3125 3130 atg gcc agc acc tac ttt gac atc cgc ggc gtg ctg gac cgg ggc 18688 Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly 3135 3140 3145 cct agc ttc aaa ccc tac tcc ggc acc gcc tac aac agc ctg gct 18733 Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala 3150 3155 3160 ccc aag gga gcg ccc aat tcc agc cag tgg gag caa aaa aag act 18778 Pro Lys Gly Ala Pro Asn Ser Ser Gln Trp Glu Gln Lys Lys Thr 3165 3170 3175 ggc aat aat gcc aat gga gat acg gag aat gtc act tat ggt gta 18823 Gly Asn Asn Ala Asn Gly Asp Thr Glu Asn Val Thr Tyr Gly Val 3180 3185 3190 gct gcc atg gga gga att gac atc gat aaa aat ggc ctt caa att 18868 Ala Ala Met Gly Gly Ile Asp Ile Asp Lys Asn Gly Leu Gln Ile 3195 3200 3205 gga acc gat gac acc aaa gat aac gat aat gac att tat gca gac 18913 Gly Thr Asp Asp Thr Lys Asp Asn Asp Asn Asp Ile Tyr Ala Asp 3210 3215 3220 aaa aca tat cag cct gag ccg caa ata gga gag gaa aac tgg caa 18958 Lys Thr Tyr Gln Pro Glu Pro Gln Ile Gly Glu Glu Asn Trp Gln 3225 3230 3235 gaa aca tat tcc tac tat gga ggt aga gct ctt aaa aaa gat acc 19003 Glu Thr Tyr Ser Tyr Tyr Gly Gly Arg Ala Leu Lys Lys Asp Thr 3240 3245 3250 aaa atg aag cca tgc tat ggc tca ttt gcc aga cct acc aat gtg 19048 Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Arg Pro Thr Asn Val 3255 3260 3265 aaa gga gga cag gca aaa ata aaa aca gat gga gat gtt aag tca 19093 Lys Gly Gly Gln Ala Lys Ile Lys Thr Asp Gly Asp Val Lys Ser 3270 3275 3280 ttt gac ata gac cta gcc ttc ttt gat att ccc aat tct ggc gcg 19138 Phe Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro Asn Ser Gly Ala 3285 3290 3295 gga aat ggc aca aat gtt aac aat tat cca gat atg gtt atg tat 19183 Gly Asn Gly Thr Asn Val Asn Asn Tyr Pro Asp Met Val Met Tyr 3300 3305 3310 aca gaa aat gta aat ctg gaa acc cca gat act cat att gtg tac 19228 Thr Glu Asn Val Asn Leu Glu Thr Pro Asp Thr His Ile Val Tyr 3315 3320 3325 aaa cca gga act tca gat gac agc tca aag gtc aac ttg tgt cag 19273 Lys Pro Gly Thr Ser Asp Asp Ser Ser Lys Val Asn Leu Cys Gln 3330 3335 3340 caa tcc atg cct aac aga ccc aat tat att ggc ttc aga gac aat 19318 Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn 3345 3350 3355 ttt att ggg ctt atg tac tac aac agc act ggc aat atg ggt gtg 19363 Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val 3360 3365 3370 ctg gct ggt cag gcc tct caa ctg aat gcc gtg gtg gac ttg caa 19408 Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln 3375 3380 3385 gac aga aac aca gag ctg tcc tac cag ctc ttg ctt gac tct ctg 19453 Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu 3390 3395 3400 ggt gac aga acc agg tat ttc agt atg tgg aat cag gcg gtg gac 19498 Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp 3405 3410 3415 agt tat gat cct gat gtg cgc att att gaa aac cat ggt gtg gag 19543 Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly Val Glu 3420 3425 3430 gat gaa ttg cca aac tat tgc ttc ccc ttg gat gga gca ggc acc 19588 Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr 3435 3440 3445 aat tcg gtt tac caa ggt gtt aaa cca aaa act gac aat ggc aac 19633 Asn Ser Val Tyr Gln Gly Val Lys Pro Lys Thr Asp Asn Gly Asn 3450 3455 3460 gat cag tgg gaa aca gat tcc aca gtt tca agt cac aat cag ata 19678 Asp Gln Trp Glu Thr Asp Ser Thr Val Ser Ser His Asn Gln Ile 3465 3470 3475 tgc aaa ggc aat atc tat gcc atg gag atc aac ctc cag gcc aac 19723 Cys Lys Gly Asn Ile Tyr Ala Met Glu Ile Asn Leu Gln Ala Asn 3480 3485 3490 ctg tgg aga agt ttt ctc tac tcg aac gtg gcc ctg tac ctg ccc 19768 Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro 3495 3500 3505 gat tct tac aag tac acg ccg gcc aac atc acc ctg ccc acc aac 19813 Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn 3510 3515 3520 acc aac acc tac gat tac atg aac ggg aga gtg gtg cct ccc tcg 19858 Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Pro Pro Ser 3525 3530 3535 ctg gtg gac gcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac 19903 Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp 3540 3545 3550 ccc atg gac aac gtg aat ccc ttc aac cac cac cgc aac gcg ggc 19948 Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly 3555 3560 3565 ctg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg ccc 19993 Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro 3570 3575 3580 ttc cac atc cag gtg ccc cag aaa ttt ttc gcc att aag agc ctc 20038 Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu 3585 3590 3595 ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag 20083 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys 3600 3605 3610 gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc 20128 Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg 3615 3620 3625 acg gac ggg gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc 20173 Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala 3630 3635 3640 acc ttc ttc ccc atg gcg cac aac acg gct tcc acg ctc gag gcc 20218 Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala 3645 3650 3655 atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac tac ctc 20263 Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu 3660 3665 3670 tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc acc aac 20308 Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn 3675 3680 3685 gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc 20353 Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly 3690 3695 3700 tgg tcc ttc acg cgc ctc aag acc aag gag acg ccc tcg ctg ggc 20398 Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly 3705 3710 3715 tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac 20443 Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr 3720 3725 3730 ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag gtc tcc 20488 Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser 3735 3740 3745 atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc 20533 Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu 3750 3755 3760 ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac ggc gag 20578 Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu 3765 3770 3775 ggc tac aac gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg 20623 Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu 3780 3785 3790 gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc ttc tac 20668 Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr 3795 3800 3805 gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac 20713 Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn 3810 3815 3820 ttc cag ccc atg agc cgc cag gtg gtg gac gag gtc aac tac aag 20758 Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys 3825 3830 3835 gac tac cag gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc 20803 Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly 3840 3845 3850 ttc gtc ggc tac ctc gcg ccc acc atg tgc cag ggc cag ccc tac 20848 Phe Val Gly Tyr Leu Ala Pro Thr Met Cys Gln Gly Gln Pro Tyr 3855 3860 3865 ccc gcc aac tac ccg tac ccg ctc atc ggc aag agc gcc gtc acc 20893 Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr 3870 3875 3880 agc gtc acc cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc 20938 Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg 3885 3890 3895 atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac 20983 Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp 3900 3905 3910 ctc ggc cag aac atg ctc tat gcc aac tcc gcc cac gcg cta gac 21028 Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp 3915 3920 3925 atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat 21073 Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr 3930 3935 3940 gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac 21118 Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His 3945 3950 3955 cgc ggc gtc atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc 21163 Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala 3960 3965 3970 ggt aac gcc acc acc taagctcttg cttcttgcaa gct atg gct gag ccc 21213 Gly Asn Ala Thr Thr Met Ala Glu Pro 3975 3980 acg ggc tcc ggc gag cag gag ctc agg gcc atc atc cgc gac ctg 21258 Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu 3985 3990 3995 ggc tgc ggg ccc tac ttc ctg ggc acc ttc gat aag cgc ttc ccg 21303 Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro 4000 4005 4010 gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac acg 21348 Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr 4015 4020 4025 gcc ggc cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg 21393 Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 4030 4035 4040 aac ccg cgc tcg aac acc tgc tac ctc ttc gac ccc ttc ggg ttc 21438 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 4045 4050 4055 tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag ggc 21483 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly 4060 4065 4070 ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc acc 21528 Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr 4075 4080 4085 ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc gcc 21573 Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala 4090 4095 4100 tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg 21618 Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp 4105 4110 4115 ccc gac cgc ccc atg gac aag aac ccc acc atg aac tta ctg acg 21663 Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr 4120 4125 4130 ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc acc 21708 Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr 4135 4140 4145 ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aac gcc cac 21753 Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His 4150 4155 4160 tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc acc 21798 Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr 4165 4170 4175 gcc ttc gac cgc atg aat caa gac atg taaaccgtgt gtgtatgtga 21845 Ala Phe Asp Arg Met Asn Gln Asp Met 4180 4185 atgctttatt cataataaac agcacatgtt tatgccacct tctctgaggc tctgacttta 21905 tttagaaatc gaaggggttc tgccggctct cggcgtgccc cgcgggcagg gatacgttgc 21965 ggaactggta cttgggcagc cacttgaact cggggatcag cagcttcggc acggggaggt 22025 cggggaacga gtcgctccac agcttgcgcg tgagttgcag ggcgcccagc aggtcgggcg 22085 cggagatctt gaaatcacag ttgggacccg cgttctgcgc gcgagagttg cggtacacgg 22145 ggttgcagca ctggaacacc atcagggccg ggtgcttcac gctcgccagc accgtcgcgt 22205 cggtgatgcc ctccatgtcc agatcctcgg cgttggccat cccgaagggg gtcatcttgc 22265 aggtctgccg ccccatgctg ggcacgcagc cgggcttgtg gttgcaatcg cagtgcaggg 22325 ggatcagcat catctgggcc tgttcggagc tcatgcccgg gtacatggcc ttcatgaaag 22385 cctccagctg gcggaaggcc tgctgcgcct tgccgccctc ggtgaagaag accccgcagg 22445 acttgctaga gaactggttg gtggcgcagc ccgcgtcgtg cacgcagcag cgcgcgtcgt 22505 tgttggccag ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg 22565 ggttctcctt cagcgcgcgc tgcccgttct cgctcgccac atccatctcg atcgtgtgct 22625 ccttctggat catcacggtc ccgtgcaggc accgcagctt gccctcggcc tcggtgcagc 22685 cgtgcagcca cagcgcgcag ccggtgctct cccagttctt gtgggcgatc tgggagtgcg 22745 agtgcacgaa gccctgcagg aagcggccca tcatcgtggt cagggtcttg ttgctggtga 22805 aggtcagcgg gatgccgcgg tgctcctcgt tcacatacat gtggcagatg cggcggtaca 22865 cctcgccctg ctcgggcatc agctggaagg cggacttcag gtcgctctcc acgcggtacc 22925 ggtccatcag cagcgtcatg acttccatgc ccttctccca ggccgaaacg atcggcaggc 22985 tcagggggtt cttcaccgcc attgtcatct tagtcgccgc cgccgaggtc agggggtcgt 23045 tctcgtccag ggtctcaaac actcgcttgc cgtccttctc ggtgatgcgc acggggggga 23105 aggcgaagcc cacggccgcc agctcctcct cggcctgcct ttcgtcctcg ctgtcctggc 23165 tgatgtcttg caaaggcaca tgcttggtct tgcggggttt ctttttgggc ggcagaggcg 23225 gcggcgatgt gctgggcgag cgcgagttct cgctcaccac gactatttct tctccttggc 23285 cgtcgtccga gaccacgcgg cggtaggcat gcctcttctg gggcagaggc ggaggcgacg 23345 ggctctcgcg gttcggcggg cggctggcag agccccttcc gcgttcgggg gtgcgctcct 23405 ggcggcgctg ctctgactga cttcctccgc ggccggccat tgtgttctcc tagggagcaa 23465 gc atg gag act cag cca tcg tcg cca aca tcg cca tct gcc ccc gcc 23512 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala 4190 4195 4200 gcc acc gcc gac gag aac cag cag cag cag aat gaa agc tta acc 23557 Ala Thr Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr 4205 4210 4215 gcc ccg ccg ccc agc ccc acc tcc gac gcc gcg gcc cca gac atg 23602 Ala Pro Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met 4220 4225 4230 caa gag atg gag gaa tcc atc gag att gac ctg ggc tac gtg acg 23647 Gln Glu Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr 4235 4240 4245 ccc gcg gag cac gag gag gag ctg gca gcg cgc ttt tca gcc ccg 23692 Pro Ala Glu His Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro 4250 4255 4260 gaa gag aac cac caa gag cag cca gag cag gaa gca gag agc gag 23737 Glu Glu Asn His Gln Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu 4265 4270 4275 cag agc cag gct ggg ctc gag cat ggc gac tac ctg agc ggg gca 23782 Gln Ser Gln Ala Gly Leu Glu His Gly Asp Tyr Leu Ser Gly Ala 4280 4285 4290 gag gac gtg ctc atc aag cat ctg gcc cgc caa tgc atc atc gtc 23827 Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val 4295 4300 4305 aag gat gcg ctg ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg 23872 Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala 4310 4315 4320 gag ctc agc cgc gcc tac gag cgc aac ctc ttc tcg ccg cgc gtg 23917 Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val 4325 4330 4335 ccc ccc aag cgc cag ccc aac ggc acc tgc gag ccc aac ccg cgc 23962 Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg 4340 4345 4350 ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc 24007 Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr 4355 4360 4365 tac cac ctc ttt ttc aag aac caa agg atc ccc gtc tcc tgc cgc 24052 Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg 4370 4375 4380 gcc aac cgc acc cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc 24097 Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly 4385 4390 4395 gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt ccc aag atc 24142 Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 4400 4405 4410 ttc gag ggt ctg ggc agc gac gag act cgg gcc gcg aac gct ctg 24187 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 4415 4420 4425 caa gga agc gga gag gag cat gag cac cac agc gcc ctg gtg gag 24232 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu 4430 4435 4440 ttg gaa ggc gac aac gcg cgc ctg gcg gtc ctc aag cgc acg gtc 24277 Leu Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val 4445 4450 4455 gag ctg acc cac ttc gcc tac ccg gcg ctc aac ctg ccc ccc aag 24322 Glu Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys 4460 4465 4470 gtc atg agc gcc gtc atg gac cag gtg ctc atc aag cgc gcc tcg 24367 Val Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser 4475 4480 4485 ccc ctc tcg gag gag gag atg cag gac ccc gag agc tcg gac gag 24412 Pro Leu Ser Glu Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu 4490 4495 4500 ggc aag ccc gtg gtc agc gac gag cag ctg gcg cgc tgg ctg gga 24457 Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly 4505 4510 4515 gcg agt agc acc ccc cag agc ctg gaa gag cgg cgc aag ctc atg 24502 Ala Ser Ser Thr Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met 4520 4525 4530 atg gcc gtg gtc ctg gtg acc gtg gag ctg gag tgt ctg cgc cgc 24547 Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg 4535 4540 4545 ttc ttc gcc gac gcg gag acc ctg cgc aag gtc gag gag aac ctg 24592 Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu 4550 4555 4560 cac tac ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc aag atc 24637 His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile 4565 4570 4575 tcc aac gtg gag ctg acc aac ctg gtc tcc tac atg ggc atc ctg 24682 Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu 4580 4585 4590 cac gag aac cgc ctg ggg cag aac gtg ctg cac acc acc ctg cgc 24727 His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg 4595 4600 4605 ggg gag gcc cgc cgc gac tac atc cgc gac tgc gtc tac ctg tac 24772 Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr 4610 4615 4620 ctc tgc cac acc tgg cag acg ggc atg ggc gtg tgg cag cag tgc 24817 Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys 4625 4630 4635 ctg gag gag cag aac ctg aaa gag ctc tgc aag ctc ctg cag aag 24862 Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys 4640 4645 4650 aac ctg aag gcc ctg tgg acc ggg ttc gac gag cgc acc acc gcc 24907 Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 4655 4660 4665 tcg gac ctg gcc gac ctc atc ttc ccc gag cgc ctg cgg ctg acg 24952 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr 4670 4675 4680 ctg cgc aac ggg ctg ccc gac ttt atg agc caa agc atg ttg caa 24997 Leu Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln 4685 4690 4695 aac ttt cgc tct ttc atc ctc gaa cgc tcc ggg atc ctg ccc gcc 25042 Asn Phe Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala 4700 4705 4710 acc tgc tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc 25087 Thr Cys Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg 4715 4720 4725 gag tgc ccc ccg ccg ctc tgg agc cac tgc tac ctg ctg cgt ctg 25132 Glu Cys Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu 4730 4735 4740 gcc aac tac ctg gcc tac cac tcg gac gtg atc gag gac gtc agc 25177 Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser 4745 4750 4755 ggc gag ggt ctg ctc gag tgc cac tgt cgc tgc aac ctc tgc acg 25222 Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr 4760 4765 4770 ccg cac cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc gag acc 25267 Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr 4775 4780 4785 cag atc atc ggc acc ttc gag ttg caa ggc ccc ggc gag gag ggc 25312 Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Gly Glu Glu Gly 4790 4795 4800 aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac 25357 Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr 4805 4810 4815 ttg cgc aag ttc gtg ccc gag gac tac cat ccc ttc gag atc agg 25402 Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg 4820 4825 4830 ttc tac gag gac caa tcc cag ccg ccc aag gcc gag ctg tcg gcc 25447 Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala 4835 4840 4845 tgc gtc atc acc cag ggg gcc atc ctg gcc caa ttg caa gcc atc 25492 Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile 4850 4855 4860 cag aaa tcc cgc caa gaa ttt ctg ctg aaa aag ggc cac ggg gtc 25537 Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val 4865 4870 4875 tac ttg gac ccc cag acc gga gag gag ctc aac ccc agc ttc ccc 25582 Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro 4880 4885 4890 cag gat gcc ccg agg aag cag caa gaa gct gaa agt gga gct gcc 25627 Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala 4895 4900 4905 gcc gga gga ttt gga gga aga ctg gga gag cag tca ggc aga gga 25672 Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 4910 4915 4920 gga gga gat gga aga ctg gga cag cac tca ggc aga gga gga cag 25717 Gly Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln 4925 4930 4935 cct gca aga cag tct gga gga aga cga ggt gga gga gga ggc aga 25762 Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg 4940 4945 4950 gga aga agc agc cgc cgc cag acc gtc gtc ctc ggc gga gga gga 25807 Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Gly 4955 4960 4965 gaa agc aag cag cac gga tac cat ctc cgc tcc ggg tcg ggg tcg 25852 Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser 4970 4975 4980 cgg cgg ccg ggc cca cag tagatgggac gagaccgggc gcttcccgaa 25900 Arg Arg Pro Gly Pro Gln 4985 ccccaccacc cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa 25960 aaacgccatc gtctcctgct tgcaagcctg cgggggcaac atctccttca cccggcgcta 26020 cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct 26080 ccacagcccc tactactgtt tccaagaaga ggcagaaacc cagcagcagc agcagaaaac 26140 cagcagcagc tagaaaatcc acggcggcag gtggactgag gatcgcggcg aacgagccgg 26200 cgcagacccg ggagctgagg aaccggatct ttcccaccct ctatgccatc ttccagcaga 26260 gtcgggggca ggagcaggaa ctgaaagtca agaaccgttc tctgcgctcg ctcacccgca 26320 gttgtctgta tcacaagagc gaagaccaac ttcagcgcac tctcgaggac gccgaggctc 26380 tcttcaacaa gtactgcgcg ctcactctta aagagtagcc cgcgcccgcc cagccgcaga 26440 aaaaggcggg aattacgtca cctgtgccct tcgcccgacc atc atg agc aaa gag 26495 Met Ser Lys Glu 4990 att ccc acg cct tac atg tgg agc tac cag ccc cag atg ggc ctg 26540 Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly Leu 4995 5000 5005 gcc gcc ggc gcc gcc cag gac tac tcc acc cgc atg aat tgg ctc 26585 Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu 5010 5015 5020 agc gcc ggg ccc gcg atg atc tca cgg gtg aat gac atc cgc gcc 26630 Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg Ala 5025 5030 5035 cac cga aac cag ata ctc cta gaa cag tca gcg ctc acc gcc acg 26675 His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 5040 5045 5050 ccc cgc aat cac ctc aac ccg cgt aat tgg ccc gcc gcc ctg gtg 26720 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val 5055 5060 5065 tac cag gaa att ccc cag ccc acg acc gta cta ctt ccg cga gac 26765 Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp 5070 5075 5080 gcc cag gcc gaa gtc cag ctg act aac tca ggt gtc cag ctg gcg 26810 Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala 5085 5090 5095 ggc ggc gcc acc ctg tgt cgt cac cgc ccc gct cag ggt ata aag 26855 Gly Gly Ala Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys 5100 5105 5110 cgg ctg gtg atc cgg ggc aga ggc aca cag ctc aac gac gag gtg 26900 Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val 5115 5120 5125 gtg agc tct tcg ctg ggt ctg cga cct gac gga gtc ttc caa ctc 26945 Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln Leu 5130 5135 5140 gcc gga tcg ggg aga tct tcc ttc acg cct cgt cag gcc gtg ctg 26990 Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val Leu 5145 5150 5155 act ttg gag agt tcg tcc tcg cag ccc cgc tcg ggc ggc atc ggc 27035 Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly 5160 5165 5170 act ctc cag ttc gtg gag gag ttc act ccc tcg gtc tac ttc aac 27080 Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn 5175 5180 5185 ccc ttc tcc ggc tcc ccc ggg cac tac ccg gac gag ttc atc ccg 27125 Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile Pro 5190 5195 5200 aac ttt gac gcc atc agc gag tcg gtg gac ggc tac gat tga atg 27170 Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp Met 5205 5210 tcc cat ggt ggc gcg gct gac ata gct cgg ctt cga cac ctg gac 27215 Ser His Gly Gly Ala Ala Asp Ile Ala Arg Leu Arg His Leu Asp 5215 5220 5225 cac tgc cgc cgc ttt cgc tgc ttc gct cgg gac ctc gcc gag ttc 27260 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe 5230 5235 5240 acc tac ttt gag ctg ccc gag gag cat cct cag ggc ccg gcc cac 27305 Thr Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His 5245 5250 5255 gga gtg cgg atc gtc gtc gaa ggg ggc cta gac tcc cac ctg ctt 27350 Gly Val Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu 5260 5265 5270 cgg atc ttc agc cag cgc ccg atc ctg gtc gag cgc caa cag ggc 27395 Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly 5275 5280 5285 aac acc ctc ctg acc ctc tac tgc atc tgc gac cac ccc ggc ctg 27440 Asn Thr Leu Leu Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu 5290 5295 5300 cat gaa agt ctt tgt tgt ctg ctg tgt act gag tat aat aaa agc 27485 His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5305 5310 5315 tgagatcagc gactactccg gactcaactg tggtgtttct gcatccatca accagtctct 27545 aaccttcacc gggaacgaga ccgagctcca gctccagtgt aagccccaca agaagtacct 27605 cacctggctg taccagggct ccccgatcgc cgttgttaac cactgcgacg acgacggagt 27665 cctgctgaac ggccccgcca accttacttt ttccacccgc agaagcaagc tactgctctt 27725 ccgacccttc ctccccggca cctatcagtg cgtctcggga ccctgccatc acaccttcca 27785 cctgatcccg aataccacct cttccccagc gccgctcccc actaacaacc aaactaacca 27845 ccaccgctac cgacgcgacc tcgttgaatc taataccacc cacaccggag gtgagctcca 27905 aggtcgcaaa ccctctggga tttattacgg cccctgggag gtggtggggt taatagcttt 27965 aggcttagta gcgggtgggc ttttggctct ctgctaccta tacatccctt gctgttctta 28025 cttagtggtg ctgtgttgct ggtttaagaa atg ggg cag atc acc cta gtg 28076 Met Gly Gln Ile Thr Leu Val 5320 5325 agc tgc ggt gtg ctg gtg gcg gtg gtg ctt tcg att gtg gga ctg 28121 Ser Cys Gly Val Leu Val Ala Val Val Leu Ser Ile Val Gly Leu 5330 5335 5340 ggc ggc gcg gct gta gtg aag gag aag gcc gat ccc tgc ttg cat 28166 Gly Gly Ala Ala Val Val Lys Glu Lys Ala Asp Pro Cys Leu His 5345 5350 5355 ttc aat ccc gac aaa tgc cag ctg agt ttt cag ccc gat ggc aat 28211 Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln Pro Asp Gly Asn 5360 5365 5370 cgg tgc gcg gtg ctg atc aag tgc gga tgg gaa tgc gag aac gtg 28256 Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys Glu Asn Val 5375 5380 5385 aga atc gag tac aat aac aag act cgg aac aat act ctc gcg tcc 28301 Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu Ala Ser 5390 5395 5400 gtg tgg cag ccc ggg gac ccc gag tgg tac acc gtc tct gtc ccc 28346 Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val Pro 5405 5410 5415 ggt gct gac ggc tcc ccg cgc acc gtg aat aat act ttc att ttt 28391 Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 5420 5425 5430 gcg cac atg tgc gac acg gtc atg tgg atg agc aag cag tac gat 28436 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp 5435 5440 5445 atg tgg ccc ccc acg aag gag aac atc gtg gtc ttc tcc atc gct 28481 Met Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala 5450 5455 5460 tac agc gtg tgc acg gcg cta atc acc gct atc gtg tgc ctg agc 28526 Tyr Ser Val Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser 5465 5470 5475 att cac atg ctc atc gct att cgc ccc aga aat aat gcc gaa aaa 28571 Ile His Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys 5480 5485 5490 gaa aaa cag cca taacacgttt tttcacacac ctttttcaga cc atg gcc tct 28624 Glu Lys Gln Pro Met Ala Ser 5495 gtt aaa ttt ttg ctt tta ttt gcc agt ctc att acc gtc att cat 28669 Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val Ile His 5500 5505 5510 gga atg agt aat gag aaa att act att tac act ggc act aat cac 28714 Gly Met Ser Asn Glu Lys Ile Thr Ile Tyr Thr Gly Thr Asn His 5515 5520 5525 aca ttg aaa ggt cca gaa aaa gcc aca gaa gtt tca tgg tat tgt 28759 Thr Leu Lys Gly Pro Glu Lys Ala Thr Glu Val Ser Trp Tyr Cys 5530 5535 5540 tat ttt aat gaa tca gat gta tct act gaa ctc tgt gga aac aag 28804 Tyr Phe Asn Glu Ser Asp Val Ser Thr Glu Leu Cys Gly Asn Lys 5545 5550 5555 aac aaa aaa aat gag agc att act ctc atc aag ttt caa tgt gga 28849 Asn Lys Lys Asn Glu Ser Ile Thr Leu Ile Lys Phe Gln Cys Gly 5560 5565 5570 tct gac tta acc cta att aac atc act aga gac tat gta ggt atg 28894 Ser Asp Leu Thr Leu Ile Asn Ile Thr Arg Asp Tyr Val Gly Met 5575 5580 5585 tat tat gga act aca gca ggc att tca gac atg gaa ttt tat caa 28939 Tyr Tyr Gly Thr Thr Ala Gly Ile Ser Asp Met Glu Phe Tyr Gln 5590 5595 5600 gtt tct gtg tct gaa ccc acc acg cct aga atg acc aca acc aca 28984 Val Ser Val Ser Glu Pro Thr Thr Pro Arg Met Thr Thr Thr Thr 5605 5610 5615 aaa act aca cct gtt acc act atg cag ctc act acc aat ggc ttt 29029 Lys Thr Thr Pro Val Thr Thr Met Gln Leu Thr Thr Asn Gly Phe 5620 5625 5630 ctt gcc atg ctt caa gtg gct gaa aat agc acc agc att caa ccc 29074 Leu Ala Met Leu Gln Val Ala Glu Asn Ser Thr Ser Ile Gln Pro 5635 5640 5645 acc cca ccc agt gag gaa att ccc aga tcc atg att ggc att att 29119 Thr Pro Pro Ser Glu Glu Ile Pro Arg Ser Met Ile Gly Ile Ile 5650 5655 5660 gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg tgc atg gtg 29164 Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val 5665 5670 5675 tac tat gcc ttc tgc tac aga aag cac aga ctg aac gac aag ctg 29209 Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu 5680 5685 5690 gaa cac tta cta agt gtt gaa ttt taatttttta gaacc atg aag atc 29257 Glu His Leu Leu Ser Val Glu Phe Met Lys Ile 5695 5700 cta ggc ctt tta att ttt tct atc att acc tct gct cta tgc aat 29302 Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu Cys Asn 5705 5710 5715 tct gac aat gag gac gtt act gtc gtt gtc gga acc aat tat aca 29347 Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Thr Asn Tyr Thr 5720 5725 5730 ctg aaa ggt cca gcg aag ggt atg ctt tcg tgg tat tgc tat ttt 29392 Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Tyr Phe 5735 5740 5745 gga tct gac act aca gaa act gaa tta tgc aat ctt aag aat ggc 29437 Gly Ser Asp Thr Thr Glu Thr Glu Leu Cys Asn Leu Lys Asn Gly 5750 5755 5760 aaa att caa aat tct aaa att aac aat tat ata tgc aat ggt act 29482 Lys Ile Gln Asn Ser Lys Ile Asn Asn Tyr Ile Cys Asn Gly Thr 5765 5770 5775 gat ctg ata ctc ctc aat atc acg aaa tca tat gct ggc agt tac 29527 Asp Leu Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr 5780 5785 5790 acc tgc cct gga gat gat gct gac agt atg att ttt tac aaa gta 29572 Thr Cys Pro Gly Asp Asp Ala Asp Ser Met Ile Phe Tyr Lys Val 5795 5800 5805 act gtt gtt gat cct act act cca cct ccg ccc acc acc aca act 29617 Thr Val Val Asp Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr 5810 5815 5820 act cac acc aca cac ata gaa caa acc aca gca gag gca gca gga 29662 Thr His Thr Thr His Ile Glu Gln Thr Thr Ala Glu Ala Ala Gly 5825 5830 5835 gag tta gcc ttg cag gtt cag gaa gat tcc ctt atg gct aat acc 29707 Glu Leu Ala Leu Gln Val Gln Glu Asp Ser Leu Met Ala Asn Thr 5840 5845 5850 cct aca ccc gat cat cgg tgt ccg ggg ctg ctc gtc agc ggc att 29752 Pro Thr Pro Asp His Arg Cys Pro Gly Leu Leu Val Ser Gly Ile 5855 5860 5865 gtc ggt gtg ctt tcg gga tta gca gtc ata atc atc tgc atg ttc 29797 Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys Met Phe 5870 5875 5880 att ttt gct tgc tgc tat aga agg ctt tac cga caa aaa tca gac 29842 Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys Ser Asp 5885 5890 5895 cca ctg ctg aac ctc tat gtt taattttttc cagagcc atg aag gca gtt 29892 Pro Leu Leu Asn Leu Tyr Val Met Lys Ala Val 5900 5905 5910 agc gct cta gtt ttt tgt tct ttg att ggc att gtt ttt agt gct 29937 Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Ile Val Phe Ser Ala 5915 5920 5925 ggg ttt ttg aaa aat ctt acc att tat gaa ggt gag aat gcc act 29982 Gly Phe Leu Lys Asn Leu Thr Ile Tyr Glu Gly Glu Asn Ala Thr 5930 5935 5940 cta gtg ggc atc agt ggt caa aat gtc agc tgg cta aaa tac cat 30027 Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr His 5945 5950 5955 cta gat ggg tgg aaa gac att tgc gat tgg aat gtc act gtg tat 30072 Leu Asp Gly Trp Lys Asp Ile Cys Asp Trp Asn Val Thr Val Tyr 5960 5965 5970 aca tgt aat gga gtt aac ctc acc att act aat gcc acc caa gat 30117 Thr Cys Asn Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp 5975 5980 5985 cag aat ggt agg ttt aag ggc cag agt ttc act aga aat aat ggg 30162 Gln Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Arg Asn Asn Gly 5990 5995 6000 tat gaa tcc cat aac atg ttt atc tat gac gtc act gtc atc aga 30207 Tyr Glu Ser His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Arg 6005 6010 6015 aac gag act gcc acc aca cag atg ccc act aca cac agt tct acc 30252 Asn Glu Thr Ala Thr Thr Gln Met Pro Thr Thr His Ser Ser Thr 6020 6025 6030 act act agc atg caa acc aca cag aca acc act ttt tat aca tca 30297 Thr Thr Ser Met Gln Thr Thr Gln Thr Thr Thr Phe Tyr Thr Ser 6035 6040 6045 act cag cat atc acc act aca gca gca aag cca agt agc gca gcg 30342 Thr Gln His Ile Thr Thr Thr Ala Ala Lys Pro Ser Ser Ala Ala 6050 6055 6060 cct cag cca cag gct ttg gct ttg aaa gct gca caa cct agt aca 30387 Pro Gln Pro Gln Ala Leu Ala Leu Lys Ala Ala Gln Pro Ser Thr 6065 6070 6075 act act agg acc aat gag cag act act gat ttt ttg tcc act gtc 30432 Thr Thr Arg Thr Asn Glu Gln Thr Thr Asp Phe Leu Ser Thr Val 6080 6085 6090 gag agc cac acc aca gct acc tcg agt gcc ttc tct agc acc gcc 30477 Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala 6095 6100 6105 aat ctc tcc tcg ctt tcc tct aca cca atc agt ccc gct act act 30522 Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 6110 6115 6120 cct acc ccc gct ctt ctc ccc act ccc ctg aag caa act gag aac 30567 Pro Thr Pro Ala Leu Leu Pro Thr Pro Leu Lys Gln Thr Glu Asn 6125 6130 6135 agc ggc atg caa tgg cag atc acc ctg ctc att gtg atc ggg ttg 30612 Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu 6140 6145 6150 gtc atc ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc cgc att 30657 Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile 6155 6160 6165 ccc aac gcg cac cgc aag ccg gtc tac aag ccc atc gtt atc ggg 30702 Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Val Ile Gly 6170 6175 6180 cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc 30747 Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu 6185 6190 6195 ttc tct ttt aca gta tgg tgattgaact atg att cct aga caa ttc ttg 30796 Phe Ser Phe Thr Val Trp Met Ile Pro Arg Gln Phe Leu 6200 6205 atc act att ctt atc tgc ctc ctc caa gtc tgt gcc acc ctc gct 30841 Ile Thr Ile Leu Ile Cys Leu Leu Gln Val Cys Ala Thr Leu Ala 6210 6215 6220 cta gtg gcc aac gcc agt cca gac tgt att ggg ccc ttc gcc tcc 30886 Leu Val Ala Asn Ala Ser Pro Asp Cys Ile Gly Pro Phe Ala Ser 6225 6230 6235 tac gtg ctc ttt gcc ttc atc acc tgc atc tgc tgc tgt agc ata 30931 Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys Cys Cys Ser Ile 6240 6245 6250 gtc tgc ctg ctt atc acc ttc ttc cag ttc att gac tgg atc ttt 30976 Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp Trp Ile Phe 6255 6260 6265 gtg cgc atc gcc tac ctg cgc cac cac ccc cag tac cgc gac cag 31021 Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg Asp Gln 6270 6275 6280 caa gtg gcg cga ctg ctc agg ctc ctc tgataagc atg cgg gct ctg 31068 Gln Val Ala Arg Leu Leu Arg Leu Leu Met Arg Ala Leu 6285 6290 6295 cta ctt ctc gcg ctt ctg ctg tta gtg ctc ccc cgt ccc gtc gac 31113 Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val Asp 6300 6305 6310 ccc cgg ccc ccc act cag tcc ccc gag gag gtc cgc aaa tgc aaa 31158 Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys 6315 6320 6325 ttc caa gaa ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa tca 31203 Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser 6330 6335 6340 gac atg cat ccc agc tgg atc atg atc att ggg atc gtg aac att 31248 Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 6345 6350 6355 ctg gcc tgc acc ctc atc tcc ttt gtg att tac ccc tgc ttt gac 31293 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp 6360 6365 6370 ttt ggt tgg aac tcg cca gag gcg ctc tat ctc ccg cct gaa cct 31338 Phe Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro 6375 6380 6385 gac aca cca cca cag caa cct cag gca cat gca cta cca cca cag 31383 Asp Thr Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Gln 6390 6395 6400 cct agg cca caa tac atg ccc ata tta gac tat gag gcc gag cca 31428 Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro 6405 6410 6415 cag cga ccc atg ctc ccc gct att agt tac ttc aat cta acc ggc 31473 Gln Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly 6420 6425 6430 gga gat gac tgacccactg gccaacaaca acgtcaacga ccttctcctg 31522 Gly Asp Asp gacatggacg gccgcgcctc ggagcagcga ctcgcccaac tccgcatccg ccagcagcag 31582 gagagagccg tcaaggagct gcaggatgcg gtggccatcc accagtgcaa gaaaggcatc 31642 ttctgcctgg tgaagcaggc caagatcacc ttcgaggtga cttccaccga ccatcgcctc 31702 tcctacgagc tcctgcagca acgccagaag ttcacctgcc tggtcggagt caaccccatc 31762 gtcatcaccc agcagtctgg cgataccaag ggttgcatcc actgctcctg cgactccccc 31822 gagtgcgttc acaccatgat caagaccctc tgcggcctcc gcgacctcct ccccatgaac 31882 taatcaacta acccctaccc catttaccca gatacaataa agattaaaga gatgatgatt 31942 tgaattgatc aataaagaat cacttacttg aaatctgaaa ccaggtctct gtcc atg 31999 Met 6435 ttt tct gtc agc agc act tca ctc ccc tct tcc cag ctc tgg tac 32044 Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 6440 6445 6450 tgc aga ccc cgg cgg gct gca aac ttc ctc cac act ctg aag ggg 32089 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly 6455 6460 6465 atg tca aat tcc tcc tgt ccc tca atc ttc att ttt atc ttc tat 32134 Met Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr 6470 6475 6480 cag atg tcc aaa aag cgc gcg cgg gtg gat gat ggc ttc gac ccc 32179 Gln Met Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro 6485 6490 6495 gtg tac ccc tac gat gca gac aac gca ccg act gtg ccc ttc atc 32224 Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile 6500 6505 6510 aac cct ccc ttc gtc tct tca gat gga ttc caa gaa aag ccc ctg 32269 Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu 6515 6520 6525 ggg gtg ttg tcc ctg cgc ctg gcc gac ccc gtc acc acc aag aac 32314 Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn 6530 6535 6540 ggg gct gtc acc ctc aag ctg ggg gag ggg gtg gac ctc gac gag 32359 Gly Ala Val Thr Leu Lys Leu Gly Glu Gly Val Asp Leu Asp Glu 6545 6550 6555 tcg gga aaa ctc atc tcc aaa aat gcc acc aag gcc act gcc cct 32404 Ser Gly Lys Leu Ile Ser Lys Asn Ala Thr Lys Ala Thr Ala Pro 6560 6565 6570 ctc agt att tcc aac aac acc att tcc ctt aac ctg gat acc cct 32449 Leu Ser Ile Ser Asn Asn Thr Ile Ser Leu Asn Leu Asp Thr Pro 6575 6580 6585 ttt tat acc aaa gat gga aaa tta acc atg cag gta act gca cca 32494 Phe Tyr Thr Lys Asp Gly Lys Leu Thr Met Gln Val Thr Ala Pro 6590 6595 6600 tta aag tta gca aac aca gcc ata cta aac act cta gct atg gcc 32539 Leu Lys Leu Ala Asn Thr Ala Ile Leu Asn Thr Leu Ala Met Ala 6605 6610 6615 tat gga aat ggt tta ggt cta agc aac aat gct ctc act gtt cag 32584 Tyr Gly Asn Gly Leu Gly Leu Ser Asn Asn Ala Leu Thr Val Gln 6620 6625 6630 gta aca tct cca ctc acc ttt gat aat agc aaa gtc aag att aac 32629 Val Thr Ser Pro Leu Thr Phe Asp Asn Ser Lys Val Lys Ile Asn 6635 6640 6645 cta ggt aat gga cca cta atg gta tct gcc aac aag ctt tca atc 32674 Leu Gly Asn Gly Pro Leu Met Val Ser Ala Asn Lys Leu Ser Ile 6650 6655 6660 aac tgc tta cgg ggc ctg tat gtt gcc cct aat aat acc gga cta 32719 Asn Cys Leu Arg Gly Leu Tyr Val Ala Pro Asn Asn Thr Gly Leu 6665 6670 6675 gaa acc aac ata agc tgg gca aac gca atg cgc ttt gag ggt aac 32764 Glu Thr Asn Ile Ser Trp Ala Asn Ala Met Arg Phe Glu Gly Asn 6680 6685 6690 gca atg gct gtt aat ata gac aca aat aaa ggc cta caa ttt ggc 32809 Ala Met Ala Val Asn Ile Asp Thr Asn Lys Gly Leu Gln Phe Gly 6695 6700 6705 act act agt aca gaa aca ggt gtc acc aat gct tac ccc ata caa 32854 Thr Thr Ser Thr Glu Thr Gly Val Thr Asn Ala Tyr Pro Ile Gln 6710 6715 6720 gtc aaa ctt ggc gca ggc ctt gca ttt gat agc aca ggg gct att 32899 Val Lys Leu Gly Ala Gly Leu Ala Phe Asp Ser Thr Gly Ala Ile 6725 6730 6735 gtt gct tgg aac aaa gaa aat gac agc ctc act ttg tgg act aca 32944 Val Ala Trp Asn Lys Glu Asn Asp Ser Leu Thr Leu Trp Thr Thr 6740 6745 6750 cca gac ccc tct cca aat tgt aaa ata gct tct gaa aaa gat gca 32989 Pro Asp Pro Ser Pro Asn Cys Lys Ile Ala Ser Glu Lys Asp Ala 6755 6760 6765 aaa ctc aca ctt tgc ttg aca aag tgt ggt agt caa atc cta ggc 33034 Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly 6770 6775 6780 act gtc tcc cta tta gca gtc agt ggc agc ttg gct cct atc aca 33079 Thr Val Ser Leu Leu Ala Val Ser Gly Ser Leu Ala Pro Ile Thr 6785 6790 6795 ggg gct gtt agt act gca ctt gta tca ctc aaa ttc aat gcc aat 33124 Gly Ala Val Ser Thr Ala Leu Val Ser Leu Lys Phe Asn Ala Asn 6800 6805 6810 gga gcc ctt ttg gac aaa tca act ctg aac aaa gaa tac tgg aac 33169 Gly Ala Leu Leu Asp Lys Ser Thr Leu Asn Lys Glu Tyr Trp Asn 6815 6820 6825 tac aga caa gga gat cta att cca ggt aca cca tat aca cat gct 33214 Tyr Arg Gln Gly Asp Leu Ile Pro Gly Thr Pro Tyr Thr His Ala 6830 6835 6840 gtg ggt ttc atg cct aac aaa aaa gcc tac cct aaa aac aca act 33259 Val Gly Phe Met Pro Asn Lys Lys Ala Tyr Pro Lys Asn Thr Thr 6845 6850 6855 gca gct tcc aag agc cac att gtg ggt gat gtt tat tta gat gga 33304 Ala Ala Ser Lys Ser His Ile Val Gly Asp Val Tyr Leu Asp Gly 6860 6865 6870 gat gca gat aag cct tta tct ctt atc atc act ttc aat gaa act 33349 Asp Ala Asp Lys Pro Leu Ser Leu Ile Ile Thr Phe Asn Glu Thr 6875 6880 6885 gat gat gaa acc tgt gat tac tgc atc aac ttt caa tgg aaa tgg 33394 Asp Asp Glu Thr Cys Asp Tyr Cys Ile Asn Phe Gln Trp Lys Trp 6890 6895 6900 agt gct gaa caa tat aaa gaa aag aca ctc gca acc agt tca ttc 33439 Ser Ala Glu Gln Tyr Lys Glu Lys Thr Leu Ala Thr Ser Ser Phe 6905 6910 6915 acc ttc tca tac atc gcc caa gaa taaacccgcc ctgcatgcca ccccttgtcc 33493 Thr Phe Ser Tyr Ile Ala Gln Glu 6920 cactgctcta caatggaaaa ctctgaagca gaaaaataaa gttcaagtgt tttattgatt 33553 caacagtttt tcacagaatt cgagtagtta ttttccctcc tccctcccaa ctcatggaat 33613 acaccaccct ctccccacgc acagccttaa acatctgaat gccattggta atggacatgg 33673 ttttggtttc cacattccac acagtttcag agcgagccag tctcgggtcg gtcaaggaga 33733 tgaaaccctc cgggcactcc tgcatctgca cctcaaagtt caacagctga gggctgtcct 33793 cggtggtcgg gatcacggtt atctggaaga agagcgatga gagtcataat ccgcgaatgg 33853 gatcgggcgg ttgtgttgca tcaggccccg cagcagtcgc tgtctgcgcc gctccgtcaa 33913 gctgctgctc aaggggaccg ggtccaggga ctccctacgc atgatgccga tggccctgag 33973 catcagtcgc ctggtgcggc gggcgcagca gcggatgcgg atctcgctca ggtcggagca 34033 gtacgtgcag cacagcacca ccaagttgtt caacagtcca tagttcaacg tgctccagcc 34093 aaaactcatc tgtggaacta tgctgcccac atgtccatcg taccagatcc tgatgtaaat 34153 caggtggcgc cccctccaga acacactgcc catgtacatg atctccttgg gcatatgcag 34213 gttcaccacc tcccggtacc acatcacccg ctggttgaac atgcagccct ggataattct 34273 gcggaaccag atggccagca ccgccccgcc cgccatgcag cgcagggacc ccgggtcctg 34333 acagtggcag tggaggaccc accgctcgcg gccgtggatc aactgggagc tgaacaggtc 34393 tatgttggca cagcacaggc acacgctcat gcatgtcttc agcactctca gttcctcggg 34453 ggtcaggacc atgtcccagg gcacggggaa ctcttgcagg acagtgaacc cggcagaaca 34513 gggcagccct cgcacacaac ttacattgtg catggacagg gtatcgcaat caggcagcac 34573 cgggtgatcc tccaccagag aagcgcgggt ctcggtctcc tcacagcgtg gtaagggggc 34633 cggccgatac gggtgatggc gggacgcggc tgatcgtgtt cgcgaccgtg tcatgatgca 34693 gttgctttcg gacattttcg tacttgctgt agcagaacct ggtccgggcg ctgcacaccg 34753 atcgccggcg gcggtcccgg cgcttggaac gctcggtgtt gaagttgtaa aacagccact 34813 ctctcagacc gtgcagcaga tctagggcct caggagtgat gaagatccca tcatgcctga 34873 tggctctaat cacatcgacc accgtggaat gggccagacc cagccagatg atgcaatttt 34933 gttgggtttc ggtgacggcg ggggagggaa gaacaggaag aaccatgatt aacttttaat 34993 ccaaacggtc tcggagcact tcaaaatgaa gatcgcggag atggcacctc tcgcccccgc 35053 tgtgttggtg gaaaataaca gccaggtcaa aggtgatacg gttctcgaga tgttccacgg 35113 tggcttccag caaagcctcc acgcgcacat ccagaaacaa gacaatagcg aaagcgggag 35173 ggttctctaa ttcctcaatc atcatgttac actcctgcac catccccaga taattttcat 35233 ttttccagcc ttgaatgatt cgaactagtt cctgaggtaa atccaagcca gccatgataa 35293 agagctcgcg cagagcgccc tccaccggca ttcttaagca caccctcata attccaagat 35353 attctgctcc tggttcacct gcagcagatt gacaagcgga atatcaaaat ctctgccgcg 35413 atccctaagc tcctccctca gcaataactg taagtactct ttcatatcct ctccgaaatt 35473 tttagccata ggaccgccag gaatgagatt aggacaagcc acattacaga taaaccgaag 35533 tcccccccag tgagcattgc caaatgtaag attgaaataa gcatgctggc tagacccggt 35593 gatatcttcc agataactgg acagaaaatc gcccaggcaa tttttaagaa aatcaacaaa 35653 agaaaaatct tccaggtgca cgtttagggc ctcgggaaca acgatggagt aagtgcaagg 35713 ggtgcgttcc agcatggtta gttagctgat ctgtaaaaaa acaaaaaata aaacattaaa 35773 ccatgctagc ctggcgaaca ggtgggtaaa tcgttctctc cagcaccagg caggccacgg 35833 ggtctccggc gcgaccctcg taaaaattgt cgctatgatt gaaaaccatc acagagagac 35893 gttcccggtg gccggcgtga atgattcgac aagatgaata cacccccgga acattggcgt 35953 ccgcgagtga aaaaaagcgg ccgaggaagc aataaggcac tacaatgctc agtctcaagt 36013 ccagcaaagc gatgccatgc ggatgaagca caaaattctc aggtgcgtac aaaatgtaat 36073 tactcccctc ctgcacaggc agcaaagccc cagatccctc cagatacaca tacaaagcct 36133 cagcgtccat agcttaccga gcagcagcac acaacaggcg caagagtcag agaaaggctg 36193 agctctaacc tgtcccccgc tctctgctca atatatagcc cagatctaca ctgacgtaaa 36253 ggccaaagtc taaaaatacc cgccaaataa tcacacacgc ccagcacacg cccagaaacc 36313 ggtgacacac tcaaaaaaat acgcgcactt cctcaaacgc ccaaactgcc gtcatttccg 36373 ggttcccacg ctacgtcatc agaattcgac tttcaaatcc gtcgaccgtt aaacacgtca 36433 ctcgccccgc ccctaacggt cgcccttctc tccgccaatc accgccccgc atccccaaat 36493 tcaaacgcct catttgcata ttaacgcgca ccaaaagttt gaggtatatt attgatgatg 36553 <210> 2 <211> 504 <212> PRT <213> Simian adenovirus 39 <400> 2 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg 65 70 75 80 Ser Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro 85 90 95 Glu Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly 100 105 110 Ile Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr 115 120 125 Val Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu 130 135 140 Val Gln Ser Gln Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr 145 150 155 160 Ser Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp 165 170 175 Glu Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys 180 185 190 Lys Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile 195 200 205 Ser Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Ala Ala 210 215 220 Phe Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu 225 230 235 240 Gly Val Thr Phe Met Asn Thr Arg Phe Arg Gly Asp Gly Tyr Asn Gly 245 250 255 Val Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe 260 265 270 Phe Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val 275 280 285 Arg Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Ile Val Gly Arg Thr 290 295 300 Lys Ser Val Leu Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu 305 310 315 320 Gly Val Met Ser Glu Gly Glu Ala Arg Ile Arg His Cys Ala Ser Thr 325 330 335 Glu Thr Gly Cys Phe Val Leu Cys Lys Gly Asn Ala Lys Ile Lys His 340 345 350 Asn Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr 355 360 365 Cys Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser 370 375 380 His Ala Arg Lys Pro Trp Pro Glu Phe Glu His Asn Val Met Thr Arg 385 390 395 400 Cys Asn Met His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln 405 410 415 Cys Asn Leu Asn Tyr Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser 420 425 430 Arg Val Ser Leu Thr Gly Val Phe Asp Met Asn Val Asp Val Trp Lys 435 440 445 Ile Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys 450 455 460 Gly Gly Lys His Ala Arg Phe Gln Pro Val Cys Val Asp Val Thr Glu 465 470 475 480 Asp Leu Arg Pro Asp His Leu Val Leu Ser Cys Thr Gly Thr Glu Phe 485 490 495 Gly Ser Ser Gly Glu Glu Ser Asp 500 <210> 3 <211> 142 <212> PRT <213> Simian adenovirus 39 <400> 3 Met Ser Gly Ser Gly Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu 1 5 10 15 Thr Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly 20 25 30 Ser Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu 35 40 45 Thr Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala 50 55 60 Ala Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Met Gly Ala 65 70 75 80 Gly Tyr Tyr Gly Thr Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro 85 90 95 Ala Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu 100 105 110 Ala Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu 115 120 125 Gln Glu Gln Thr Arg Ala Ala Val Ala Thr Val Lys Ser Lys 130 135 140 <210> 4 <211> 393 <212> PRT <213> Simian adenovirus 39 <400> 4 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro 20 25 30 Gln Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly 35 40 45 Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala 50 55 60 Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys 65 70 75 80 Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp 85 90 95 Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala 100 105 110 Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp 115 120 125 Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala 130 135 140 His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys 145 150 155 160 Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu 165 170 175 Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu 180 185 190 Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln 195 200 205 Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu 210 215 220 Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu 225 230 235 240 Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu 245 250 255 Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys 260 265 270 Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys 275 280 285 Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu 290 295 300 Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg 305 310 315 320 Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met 325 330 335 His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser 340 345 350 Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 355 360 365 Leu Glu Ala Ala Ala Gly Pro Tyr Val Glu Glu Val Asp Asp Glu Val 370 375 380 Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 5 <211> 590 <212> PRT <213> Simian adenovirus 39 <400> 5 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Leu Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala Ala Arg 530 535 540 Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp Asp Glu 545 550 555 560 Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly 565 570 575 Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 590 <210> 6 <211> 532 <212> PRT <213> Simian adenovirus 39 <400> 6 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Met Gln Pro Pro Leu Glu 20 25 30 Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn 35 40 45 Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu 50 55 60 Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln 65 70 75 80 Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe 85 90 95 Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser 100 105 110 Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn 115 120 125 Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val 130 135 140 Ser Arg Lys Thr Pro Asn Gly Val Gly Glu Asp Tyr Asp Gly Ser Gln 145 150 155 160 Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala Glu 290 295 300 Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn 305 310 315 320 Phe Ala Ser Pro Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr Glu 325 330 335 Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asn Arg Ser 340 345 350 Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp Tyr 355 360 365 Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 370 375 380 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp 385 390 395 400 Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 405 410 415 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr 420 425 430 Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg 435 440 445 Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln 450 455 460 Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn 465 470 475 480 Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 485 490 495 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys 500 505 510 Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser 515 520 525 Ser Arg Thr Phe 530 <210> 7 <211> 193 <212> PRT <213> Simian adenovirus 39 <400> 7 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 8 <211> 347 <212> PRT <213> Simian adenovirus 39 <400> 8 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly 35 40 45 Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Gln Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Leu Lys Glu Glu 115 120 125 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys 130 135 140 Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly 145 150 155 160 Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val 165 170 175 Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val Asp 180 185 190 Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala 195 200 205 Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 210 215 220 Met Glu Thr Gln Thr Glu Pro Met Ile Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Pro Thr Ser Ser Arg 245 250 255 Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr 260 265 270 Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 275 280 285 Phe Tyr Arg Gly His Thr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser Ala Ala 305 310 315 320 Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu 325 330 335 Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 9 <211> 77 <212> PRT <213> Simian adenovirus 39 <400> 9 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 10 <211> 259 <212> PRT <213> Simian adenovirus 39 <400> 10 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 11 <211> 940 <212> PRT <213> Simian adenovirus 39 <400> 11 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Ile His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Gln Lys Lys Thr Gly Asn Asn Ala 130 135 140 Asn Gly Asp Thr Glu Asn Val Thr Tyr Gly Val Ala Ala Met Gly Gly 145 150 155 160 Ile Asp Ile Asp Lys Asn Gly Leu Gln Ile Gly Thr Asp Asp Thr Lys 165 170 175 Asp Asn Asp Asn Asp Ile Tyr Ala Asp Lys Thr Tyr Gln Pro Glu Pro 180 185 190 Gln Ile Gly Glu Glu Asn Trp Gln Glu Thr Tyr Ser Tyr Tyr Gly Gly 195 200 205 Arg Ala Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe 210 215 220 Ala Arg Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Ile Lys Thr Asp 225 230 235 240 Gly Asp Val Lys Ser Phe Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro 245 250 255 Asn Ser Gly Ala Gly Asn Gly Thr Asn Val Asn Asn Tyr Pro Asp Met 260 265 270 Val Met Tyr Thr Glu Asn Val Asn Leu Glu Thr Pro Asp Thr His Ile 275 280 285 Val Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Lys Val Asn Leu Cys 290 295 300 Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn 305 310 315 320 Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu 325 330 335 Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg 340 345 350 Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg 355 360 365 Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro 370 375 380 Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn 385 390 395 400 Tyr Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ser Val Tyr Gln Gly 405 410 415 Val Lys Pro Lys Thr Asp Asn Gly Asn Asp Gln Trp Glu Thr Asp Ser 420 425 430 Thr Val Ser Ser His Asn Gln Ile Cys Lys Gly Asn Ile Tyr Ala Met 435 440 445 Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn 450 455 460 Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile 465 470 475 480 Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val 485 490 495 Val Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp 500 505 510 Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn 515 520 525 Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val 530 535 540 Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu 545 550 555 560 Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp 565 570 575 Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp 580 585 590 Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe 595 600 605 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn 610 615 620 Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met 625 630 635 640 Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro 645 650 655 Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys 660 665 670 Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val 675 680 685 Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His 690 695 700 Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro 705 710 715 720 Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr 725 730 735 Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp 740 745 750 Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly 755 760 765 Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg 770 775 780 Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys 785 790 795 800 Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe 805 810 815 Val Gly Tyr Leu Ala Pro Thr Met Cys Gln Gly Gln Pro Tyr Pro Ala 820 825 830 Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr 835 840 845 Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser 850 855 860 Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met 865 870 875 880 Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val Asp 885 890 895 Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe Asp 900 905 910 Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr 915 920 925 Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 12 <211> 208 <212> PRT <213> Simian adenovirus 39 <400> 12 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 13 <211> 801 <212> PRT <213> Simian adenovirus 39 <400> 13 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Thr Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro 20 25 30 Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met 35 40 45 Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 50 55 60 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 65 70 75 80 Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Ser Gln Ala Gly Leu 85 90 95 Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 100 105 110 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 115 120 125 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn 130 135 140 Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys 145 150 155 160 Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 165 170 175 Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 180 185 190 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly 195 200 205 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys 210 215 220 Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 225 230 235 240 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 290 295 300 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly 610 615 620 Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His 625 630 635 640 Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala 645 650 655 Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu 660 665 670 Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His 675 680 685 Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe 690 695 700 Pro Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala 705 710 715 720 Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly 725 730 735 Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 740 745 750 Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser 755 760 765 Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Gly Glu Ser Lys Gln 770 775 780 His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro 785 790 795 800 Gln <210> 14 <211> 227 <212> PRT <213> Simian adenovirus 39 <400> 14 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 15 <211> 106 <212> PRT <213> Simian adenovirus 39 <400> 15 Met Ser His Gly Gly Ala Ala Asp Ile Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 16 <211> 176 <212> PRT <213> Simian adenovirus 39 <400> 16 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Val Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 17 <211> 206 <212> PRT <213> Simian adenovirus 39 <400> 17 Met Ala Ser Val Lys Phe Leu Leu Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile His Gly Met Ser Asn Glu Lys Ile Thr Ile Tyr Thr Gly Thr Asn 20 25 30 His Thr Leu Lys Gly Pro Glu Lys Ala Thr Glu Val Ser Trp Tyr Cys 35 40 45 Tyr Phe Asn Glu Ser Asp Val Ser Thr Glu Leu Cys Gly Asn Lys Asn 50 55 60 Lys Lys Asn Glu Ser Ile Thr Leu Ile Lys Phe Gln Cys Gly Ser Asp 65 70 75 80 Leu Thr Leu Ile Asn Ile Thr Arg Asp Tyr Val Gly Met Tyr Tyr Gly 85 90 95 Thr Thr Ala Gly Ile Ser Asp Met Glu Phe Tyr Gln Val Ser Val Ser 100 105 110 Glu Pro Thr Thr Pro Arg Met Thr Thr Thr Thr Lys Thr Thr Pro Val 115 120 125 Thr Thr Met Gln Leu Thr Thr Asn Gly Phe Leu Ala Met Leu Gln Val 130 135 140 Ala Glu Asn Ser Thr Ser Ile Gln Pro Thr Pro Pro Ser Glu Glu Ile 145 150 155 160 Pro Arg Ser Met Ile Gly Ile Ile Val Ala Val Val Val Cys Met Leu 165 170 175 Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His 180 185 190 Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 195 200 205 <210> 18 <211> 205 <212> PRT <213> Simian adenovirus 39 <400> 18 Met Lys Ile Leu Gly Leu Leu Ile Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Asn Ser Asp Asn Glu Asp Val Thr Val Val Val Gly Thr Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ala Lys Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Ser Asp Thr Thr Glu Thr Glu Leu Cys Asn Leu Lys Asn Gly Lys 50 55 60 Ile Gln Asn Ser Lys Ile Asn Asn Tyr Ile Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Ile Thr Lys Ser Tyr Ala Gly Ser Tyr Thr Cys Pro 85 90 95 Gly Asp Asp Ala Asp Ser Met Ile Phe Tyr Lys Val Thr Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Thr Thr Thr Thr Thr His Thr Thr His 115 120 125 Ile Glu Gln Thr Thr Ala Glu Ala Ala Gly Glu Leu Ala Leu Gln Val 130 135 140 Gln Glu Asp Ser Leu Met Ala Asn Thr Pro Thr Pro Asp His Arg Cys 145 150 155 160 Pro Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala 165 170 175 Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu 180 185 190 Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 205 <210> 19 <211> 295 <212> PRT <213> Simian adenovirus 39 <400> 19 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Tyr Glu Gly Glu Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Asp Ile Cys Asp Trp Asn Val Thr Val Tyr 50 55 60 Thr Cys Asn Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Arg Asn Asn Gly Tyr Glu 85 90 95 Ser His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Arg Asn Glu Thr 100 105 110 Ala Thr Thr Gln Met Pro Thr Thr His Ser Ser Thr Thr Thr Ser Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Phe Tyr Thr Ser Thr Gln His Ile Thr 130 135 140 Thr Thr Ala Ala Lys Pro Ser Ser Ala Ala Pro Gln Pro Gln Ala Leu 145 150 155 160 Ala Leu Lys Ala Ala Gln Pro Ser Thr Thr Thr Arg Thr Asn Glu Gln 165 170 175 Thr Thr Asp Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Pro Ala Thr Thr Pro Thr Pro Ala Leu Leu Pro Thr Pro Leu 210 215 220 Lys Gln Thr Glu Asn Ser Gly Met Gln Trp Gln Ile Thr Leu Leu Ile 225 230 235 240 Val Ile Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys 245 250 255 Arg Arg Ile Pro Asn Ala His Arg Lys Pro Val Tyr Lys Pro Ile Val 260 265 270 Ile Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu 275 280 285 Leu Phe Ser Phe Thr Val Trp 290 295 <210> 20 <211> 91 <212> PRT <213> Simian adenovirus 39 <400> 20 Met Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 50 55 60 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Gln Val Ala Arg Leu Leu Arg Leu Leu 85 90 <210> 21 <211> 142 <212> PRT <213> Simian adenovirus 39 <400> 21 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Gln Pro Arg Pro 100 105 110 Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met 115 120 125 Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 22 <211> 489 <212> PRT <213> Simian adenovirus 39 <400> 22 Met Phe Ser Val Ser Ser Thr Ser Leu Pro Ser Ser Gln Leu Trp Tyr 1 5 10 15 Cys Arg Pro Arg Arg Ala Ala Asn Phe Leu His Thr Leu Lys Gly Met 20 25 30 Ser Asn Ser Ser Cys Pro Ser Ile Phe Ile Phe Ile Phe Tyr Gln Met 35 40 45 Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr Pro 50 55 60 Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe 65 70 75 80 Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu 85 90 95 Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys 100 105 110 Leu Gly Glu Gly Val Asp Leu Asp Glu Ser Gly Lys Leu Ile Ser Lys 115 120 125 Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Asn Thr Ile 130 135 140 Ser Leu Asn Leu Asp Thr Pro Phe Tyr Thr Lys Asp Gly Lys Leu Thr 145 150 155 160 Met Gln Val Thr Ala Pro Leu Lys Leu Ala Asn Thr Ala Ile Leu Asn 165 170 175 Thr Leu Ala Met Ala Tyr Gly Asn Gly Leu Gly Leu Ser Asn Asn Ala 180 185 190 Leu Thr Val Gln Val Thr Ser Pro Leu Thr Phe Asp Asn Ser Lys Val 195 200 205 Lys Ile Asn Leu Gly Asn Gly Pro Leu Met Val Ser Ala Asn Lys Leu 210 215 220 Ser Ile Asn Cys Leu Arg Gly Leu Tyr Val Ala Pro Asn Asn Thr Gly 225 230 235 240 Leu Glu Thr Asn Ile Ser Trp Ala Asn Ala Met Arg Phe Glu Gly Asn 245 250 255 Ala Met Ala Val Asn Ile Asp Thr Asn Lys Gly Leu Gln Phe Gly Thr 260 265 270 Thr Ser Thr Glu Thr Gly Val Thr Asn Ala Tyr Pro Ile Gln Val Lys 275 280 285 Leu Gly Ala Gly Leu Ala Phe Asp Ser Thr Gly Ala Ile Val Ala Trp 290 295 300 Asn Lys Glu Asn Asp Ser Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser 305 310 315 320 Pro Asn Cys Lys Ile Ala Ser Glu Lys Asp Ala Lys Leu Thr Leu Cys 325 330 335 Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser Leu Leu Ala 340 345 350 Val Ser Gly Ser Leu Ala Pro Ile Thr Gly Ala Val Ser Thr Ala Leu 355 360 365 Val Ser Leu Lys Phe Asn Ala Asn Gly Ala Leu Leu Asp Lys Ser Thr 370 375 380 Leu Asn Lys Glu Tyr Trp Asn Tyr Arg Gln Gly Asp Leu Ile Pro Gly 385 390 395 400 Thr Pro Tyr Thr His Ala Val Gly Phe Met Pro Asn Lys Lys Ala Tyr 405 410 415 Pro Lys Asn Thr Thr Ala Ala Ser Lys Ser His Ile Val Gly Asp Val 420 425 430 Tyr Leu Asp Gly Asp Ala Asp Lys Pro Leu Ser Leu Ile Ile Thr Phe 435 440 445 Asn Glu Thr Asp Asp Glu Thr Cys Asp Tyr Cys Ile Asn Phe Gln Trp 450 455 460 Lys Trp Ser Ala Glu Gln Tyr Lys Glu Lys Thr Leu Ala Thr Ser Ser 465 470 475 480 Phe Thr Phe Ser Tyr Ile Ala Gln Glu 485 <210> 23 <211> 590 <212> DNA <213> Simian adenovirus 39 <220> <221> CDS <222> (10)..(585) <223> label=Elb\19K <400> 23 gcaggactc atg gag atc tgg acg gtc ttg gaa gac ttt cac cag act aga 51 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg 1 5 10 cag ctg cta gag aac tca tcg gag gaa gtc tcc tac ctg tgg aga ttc 99 Gln Leu Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe 15 20 25 30 tgc ttc ggt ggg cct cta gct aag cta gtc tat agg gcc aaa cag gat 147 Cys Phe Gly Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp 35 40 45 tat aag gat caa ttt gag gat att ttg aga gag tgt cct ggt att ttt 195 Tyr Lys Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe 50 55 60 gac tct ctc aac ttg ggc cat cag tct cac ttt aac cag agt att ctg 243 Asp Ser Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu 65 70 75 aga gcc ctt gac ttt tct act cct ggc aga act acc gcc gcg gta gcc 291 Arg Ala Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala 80 85 90 ttt ttt gcc ttt atc ctt gac aaa tgg agt caa gaa acc cat ttc agc 339 Phe Phe Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser 95 100 105 110 agg gat tac cgt ctg gac tgc tta gca gta gct ttg tgg aga aca tgg 387 Arg Asp Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp 115 120 125 agg tgc cag cgc ctg aat gca atc tcc ggc tac ttg cca gta cag ccg 435 Arg Cys Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro 130 135 140 gta gac acg ctg agg atc ctg agt ctc cag tca ccc cag gaa cac caa 483 Val Asp Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln 145 150 155 cgc cgc cag cag ccg cag cag gag cag cag caa gag gag gag gag gac 531 Arg Arg Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp 160 165 170 cga gaa gag aac ccg aga gcc ggt ctg gac cct ccg gtg gcg gag gag 579 Arg Glu Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu 175 180 185 190 gag gag tagct 590 Glu Glu <210> 24 <211> 192 <212> PRT <213> Simian adenovirus 39 <400> 24 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys 35 40 45 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu 165 170 175 Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 25 <211> 6310 <212> DNA <213> Simian adenovirus 39 <220> <221> CDS <222> (7)..(570) <223> label=22K <220> <221> CDS <222> (1862)..(2491) <223> label=E3\CR1\alpha <220> <221> CDS <222> (5898)..(6302) <223> label=E3\14.7K <400> 25 cccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 48 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag 96 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 144 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca 192 Asp Ser Leu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg gag gag gag aaa gca agc agc 240 Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser 65 70 75 acg gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac 288 Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His 80 85 90 agt aga tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc 336 Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 95 100 105 110 ggt aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac 384 Gly Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn 115 120 125 gcc atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc 432 Ala Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr 130 135 140 cgg cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc 480 Arg Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile 145 150 155 ttg cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa 528 Leu His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu 160 165 170 gag gca gaa acc cag cag cag cag cag aaa acc agc agc agc 570 Glu Ala Glu Thr Gln Gln Gln Gln Gln Lys Thr Ser Ser Ser 175 180 185 tagaaaatcc acggcggcag gtggactgag gatcgcggcg aacgagccgg cgcagacccg 630 ggagctgagg aaccggatct ttcccaccct ctatgccatc ttccagcaga gtcgggggca 690 ggagcaggaa ctgaaagtca agaaccgttc tctgcgctcg ctcacccgca gttgtctgta 750 tcacaagagc gaagaccaac ttcagcgcac tctcgaggac gccgaggctc tcttcaacaa 810 gtactgcgcg ctcactctta aagagtagcc cgcgcccgcc cagccgcaga aaaaggcggg 870 aattacgtca cctgtgccct tcgcccgacc atcatgagca aagagattcc cacgccttac 930 atgtggagct accagcccca gatgggcctg gccgccggcg ccgcccagga ctactccacc 990 cgcatgaatt ggctcagcgc cgggcccgcg atgatctcac gggtgaatga catccgcgcc 1050 caccgaaacc agatactcct agaacagtca gcgctcaccg ccacgccccg caatcacctc 1110 aacccgcgta attggcccgc cgccctggtg taccaggaaa ttccccagcc cacgaccgta 1170 ctacttccgc gagacgccca ggccgaagtc cagctgacta actcaggtgt ccagctggcg 1230 ggcggcgcca ccctgtgtcg tcaccgcccc gctcagggta taaagcggct ggtgatccgg 1290 ggcagaggca cacagctcaa cgacgaggtg gtgagctctt cgctgggtct gcgacctgac 1350 ggagtcttcc aactcgccgg atcggggaga tcttccttca cgcctcgtca ggccgtgctg 1410 actttggaga gttcgtcctc gcagccccgc tcgggcggca tcggcactct ccagttcgtg 1470 gaggagttca ctccctcggt ctacttcaac cccttctccg gctcccccgg gcactacccg 1530 gacgagttca tcccgaactt tgacgccatc agcgagtcgg tggacggcta cgattgaatg 1590 tcccatggtg gcgcggctga catagctcgg cttcgacacc tggaccactg ccgccgcttt 1650 cgctgcttcg ctcgggacct cgccgagttc acctactttg agctgcccga ggagcatcct 1710 cagggcccgg cccacggagt gcggatcgtc gtcgaagggg gcctagactc ccacctgctt 1770 cggatcttca gccagcgccc gatcctggtc gagcgccaac agggcaacac cctcctgacc 1830 ctctactgca tctgcgacca ccccggcctg c atg aaa gtc ttt gtt gtc tgc 1882 Met Lys Val Phe Val Val Cys 190 195 tgt gta ctg agt ata ata aaa gct gag atc agc gac tac tcc gga ctc 1930 Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly Leu 200 205 210 aac tgt ggt gtt tct gca tcc atc aac cag tct cta acc ttc acc ggg 1978 Asn Cys Gly Val Ser Ala Ser Ile Asn Gln Ser Leu Thr Phe Thr Gly 215 220 225 aac gag acc gag ctc cag ctc cag tgt aag ccc cac aag aag tac ctc 2026 Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys Tyr Leu 230 235 240 acc tgg ctg tac cag ggc tcc ccg atc gcc gtt gtt aac cac tgc gac 2074 Thr Trp Leu Tyr Gln Gly Ser Pro Ile Ala Val Val Asn His Cys Asp 245 250 255 gac gac gga gtc ctg ctg aac ggc ccc gcc aac ctt act ttt tcc acc 2122 Asp Asp Gly Val Leu Leu Asn Gly Pro Ala Asn Leu Thr Phe Ser Thr 260 265 270 275 cgc aga agc aag cta ctg ctc ttc cga ccc ttc ctc ccc ggc acc tat 2170 Arg Arg Ser Lys Leu Leu Leu Phe Arg Pro Phe Leu Pro Gly Thr Tyr 280 285 290 cag tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg aat 2218 Gln Cys Val Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro Asn 295 300 305 acc acc tct tcc cca gcg ccg ctc ccc act aac aac caa act aac cac 2266 Thr Thr Ser Ser Pro Ala Pro Leu Pro Thr Asn Asn Gln Thr Asn His 310 315 320 cac cgc tac cga cgc gac ctc gtt gaa tct aat acc acc cac acc gga 2314 His Arg Tyr Arg Arg Asp Leu Val Glu Ser Asn Thr Thr His Thr Gly 325 330 335 ggt gag ctc caa ggt cgc aaa ccc tct ggg att tat tac ggc ccc tgg 2362 Gly Glu Leu Gln Gly Arg Lys Pro Ser Gly Ile Tyr Tyr Gly Pro Trp 340 345 350 355 gag gtg gtg ggg tta ata gct tta ggc tta gta gcg ggt ggg ctt ttg 2410 Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Ala Gly Gly Leu Leu 360 365 370 gct ctc tgc tac cta tac atc cct tgc tgt tct tac tta gtg gtg ctg 2458 Ala Leu Cys Tyr Leu Tyr Ile Pro Cys Cys Ser Tyr Leu Val Val Leu 375 380 385 tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc tagtgagctg cggtgtgctg 2511 Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 390 395 gtggcggtgg tgctttcgat tgtgggactg ggcggcgcgg ctgtagtgaa ggagaaggcc 2571 gatccctgct tgcatttcaa tcccgacaaa tgccagctga gttttcagcc cgatggcaat 2631 cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat 2691 aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc ccggggaccc cgagtggtac 2751 accgtctctg tccccggtgc tgacggctcc ccgcgcaccg tgaataatac tttcattttt 2811 gcgcacatgt gcgacacggt catgtggatg agcaagcagt acgatatgtg gccccccacg 2871 aaggagaaca tcgtggtctt ctccatcgct tacagcgtgt gcacggcgct aatcaccgct 2931 atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa tgccgaaaaa 2991 gaaaaacagc cataacacgt tttttcacac acctttttca gaccatggcc tctgttaaat 3051 ttttgctttt atttgccagt ctcattaccg tcattcatgg aatgagtaat gagaaaatta 3111 ctatttacac tggcactaat cacacattga aaggtccaga aaaagccaca gaagtttcat 3171 ggtattgtta ttttaatgaa tcagatgtat ctactgaact ctgtggaaac aagaacaaaa 3231 aaaatgagag cattactctc atcaagtttc aatgtggatc tgacttaacc ctaattaaca 3291 tcactagaga ctatgtaggt atgtattatg gaactacagc aggcatttca gacatggaat 3351 tttatcaagt ttctgtgtct gaacccacca cgcctagaat gaccacaacc acaaaaacta 3411 cacctgttac cactatgcag ctcactacca atggctttct tgccatgctt caagtggctg 3471 aaaatagcac cagcattcaa cccaccccac ccagtgagga aattcccaga tccatgattg 3531 gcattattgt tgctgtagtg gtgtgcatgt tgatcatcgc cttgtgcatg gtgtactatg 3591 ccttctgcta cagaaagcac agactgaacg acaagctgga acacttacta agtgttgaat 3651 tttaattttt tagaaccatg aagatcctag gccttttaat tttttctatc attacctctg 3711 ctctatgcaa ttctgacaat gaggacgtta ctgtcgttgt cggaaccaat tatacactga 3771 aaggtccagc gaagggtatg ctttcgtggt attgctattt tggatctgac actacagaaa 3831 ctgaattatg caatcttaag aatggcaaaa ttcaaaattc taaaattaac aattatatat 3891 gcaatggtac tgatctgata ctcctcaata tcacgaaatc atatgctggc agttacacct 3951 gccctggaga tgatgctgac agtatgattt tttacaaagt aactgttgtt gatcctacta 4011 ctccacctcc gcccaccacc acaactactc acaccacaca catagaacaa accacagcag 4071 aggcagcagg agagttagcc ttgcaggttc aggaagattc ccttatggct aataccccta 4131 cacccgatca tcggtgtccg gggctgctcg tcagcggcat tgtcggtgtg ctttcgggat 4191 tagcagtcat aatcatctgc atgttcattt ttgcttgctg ctatagaagg ctttaccgac 4251 aaaaatcaga cccactgctg aacctctatg tttaattttt tccagagcca tgaaggcagt 4311 tagcgctcta gttttttgtt ctttgattgg cattgttttt agtgctgggt ttttgaaaaa 4371 tcttaccatt tatgaaggtg agaatgccac tctagtgggc atcagtggtc aaaatgtcag 4431 ctggctaaaa taccatctag atgggtggaa agacatttgc gattggaatg tcactgtgta 4491 tacatgtaat ggagttaacc tcaccattac taatgccacc caagatcaga atggtaggtt 4551 taagggccag agtttcacta gaaataatgg gtatgaatcc cataacatgt ttatctatga 4611 cgtcactgtc atcagaaacg agactgccac cacacagatg cccactacac acagttctac 4671 cactactagc atgcaaacca cacagacaac cactttttat acatcaactc agcatatcac 4731 cactacagca gcaaagccaa gtagcgcagc gcctcagcca caggctttgg ctttgaaagc 4791 tgcacaacct agtacaacta ctaggaccaa tgagcagact actgattttt tgtccactgt 4851 cgagagccac accacagcta cctcgagtgc cttctctagc accgccaatc tctcctcgct 4911 ttcctctaca ccaatcagtc ccgctactac tcctaccccc gctcttctcc ccactcccct 4971 gaagcaaact gagaacagcg gcatgcaatg gcagatcacc ctgctcattg tgatcgggtt 5031 ggtcatcctg gccgtgttgc tctactacat cttctgccgc cgcattccca acgcgcaccg 5091 caagccggtc tacaagccca tcgttatcgg gcagccggag ccgcttcagg tggaaggggg 5151 tctaaggaat cttctcttct cttttacagt atggtgattg aactatgatt cctagacaat 5211 tcttgatcac tattcttatc tgcctcctcc aagtctgtgc caccctcgct ctagtggcca 5271 acgccagtcc agactgtatt gggcccttcg cctcctacgt gctctttgcc ttcatcacct 5331 gcatctgctg ctgtagcata gtctgcctgc ttatcacctt cttccagttc attgactgga 5391 tctttgtgcg catcgcctac ctgcgccacc acccccagta ccgcgaccag caagtggcgc 5451 gactgctcag gctcctctga taagcatgcg ggctctgcta cttctcgcgc ttctgctgtt 5511 agtgctcccc cgtcccgtcg acccccggcc ccccactcag tcccccgagg aggtccgcaa 5571 atgcaaattc caagaaccct ggaaattcct caaatgctac cgccaaaaat cagacatgca 5631 tcccagctgg atcatgatca ttgggatcgt gaacattctg gcctgcaccc tcatctcctt 5691 tgtgatttac ccctgctttg actttggttg gaactcgcca gaggcgctct atctcccgcc 5751 tgaacctgac acaccaccac agcaacctca ggcacatgca ctaccaccac agcctaggcc 5811 acaatacatg cccatattag actatgaggc cgagccacag cgacccatgc tccccgctat 5871 tagttacttc aatctaaccg gcggag atg act gac cca ctg gcc aac aac aac 5924 Met Thr Asp Pro Leu Ala Asn Asn Asn 400 405 gtc aac gac ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga 5972 Val Asn Asp Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg 410 415 420 ctc gcc caa ctc cgc atc cgc cag cag cag gag aga gcc gtc aag gag 6020 Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu 425 430 435 ctg cag gat gcg gtg gcc atc cac cag tgc aag aaa ggc atc ttc tgc 6068 Leu Gln Asp Ala Val Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys 440 445 450 455 ctg gtg aag cag gcc aag atc acc ttc gag gtg act tcc acc gac cat 6116 Leu Val Lys Gln Ala Lys Ile Thr Phe Glu Val Thr Ser Thr Asp His 460 465 470 cgc ctc tcc tac gag ctc ctg cag caa cgc cag aag ttc acc tgc ctg 6164 Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu 475 480 485 gtc gga gtc aac ccc atc gtc atc acc cag cag tct ggc gat acc aag 6212 Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys 490 495 500 ggt tgc atc cac tgc tcc tgc gac tcc ccc gag tgc gtt cac acc atg 6260 Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu Cys Val His Thr Met 505 510 515 atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac taatcaac 6310 Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 520 525 530 <210> 26 <211> 188 <212> PRT <213> Simian adenovirus 39 <400> 26 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg 85 90 95 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys 100 105 110 Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile 115 120 125 Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg 130 135 140 Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His 145 150 155 160 Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala 165 170 175 Glu Thr Gln Gln Gln Gln Gln Lys Thr Ser Ser Ser 180 185 <210> 27 <211> 210 <212> PRT <213> Simian adenovirus 39 <400> 27 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Gln Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Leu Leu Phe Arg 85 90 95 Pro Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His His Arg Tyr Arg Arg Asp Leu Val Glu 130 135 140 Ser Asn Thr Thr His Thr Gly Gly Glu Leu Gln Gly Arg Lys Pro Ser 145 150 155 160 Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly 165 170 175 Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Ile Pro Cys 180 185 190 Cys Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg 195 200 205 Ser Pro 210 <210> 28 <211> 135 <212> PRT <213> Simian adenovirus 39 <400> 28 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Thr Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Glu Cys Val His Thr Met Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 29 <211> 870 <212> DNA <213> Simian adenovirus 39 <220> <221> CDS <222> (6)..(573) <223> label=Ela <220> <221> CDS <222> (658)..(863) <223> label=Ela <400> 29 gaaag atg agg cac ctg aga gac ctg ccc ggt aat gtt ttc ctg gct act 50 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr 1 5 10 15 ggg aac gag att ctg gaa ctg gtg gtg gac gcc atg atg ggt gac gac 98 Gly Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp 20 25 30 cct ccg gag ccc cct acc cca ttt gag gcg cct tcg ctg tac gat ttg 146 Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu 35 40 45 tat gat ctg gag gtg gat gtg ccc gag aac gac ccc aac gag gag gcg 194 Tyr Asp Leu Glu Val Asp Val Pro Glu Asn Asp Pro Asn Glu Glu Ala 50 55 60 gtg aat gat ttg ttt agc gat gcc gcg ctg ctg gct gcc gag cag gct 242 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala 65 70 75 aat atg gac tct ggc tca gac agc gat tcc tct ctc cat acc ccg aga 290 Asn Met Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg 80 85 90 95 ccc ggc aga ggt gag aaa aag atc ccc gag ctt aaa ggg gaa gag ctc 338 Pro Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu 100 105 110 gac ctg cga tgt tat gag gaa tgc ttg cct ccg agc gat gat gag gag 386 Asp Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu 115 120 125 gac gag gag acg att cga gct gcg gcg aac cag gga gtg aaa gct gcg 434 Asp Glu Glu Thr Ile Arg Ala Ala Ala Asn Gln Gly Val Lys Ala Ala 130 135 140 ggc gag agc ttt agc ctg gac tgt cct act ctg ccc gga cac ggc tgt 482 Gly Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys 145 150 155 aag tct tgt gaa ttt cat cgc atg aat act gga gat aag aat gtg atg 530 Lys Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met 160 165 170 175 tgt gcc ctg tgc tat atg aga gct tac aac cat tgt gtt tac a 573 Cys Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr 180 185 gtaagtgtga ttaactttag ctgggggggc agagggtgac tgggtgctga ctggtttatt 633 tatgtatatg ttttttatgt gtag gt ccc gtc tct gac gca gat gag acc 683 Ser Pro Val Ser Asp Ala Asp Glu Thr 195 ccc act tca gag tgc att tca tca ccc cca gaa att ggc gag gaa ccg 731 Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro Glu Ile Gly Glu Glu Pro 200 205 210 ccc gaa gat att att cat aga cca gtt gca gtg aga gtc acc ggg cgg 779 Pro Glu Asp Ile Ile His Arg Pro Val Ala Val Arg Val Thr Gly Arg 215 220 225 230 aga gca gct gtg gag agt ttg gat gac ttg cta cag ggt ggg gat gaa 827 Arg Ala Ala Val Glu Ser Leu Asp Asp Leu Leu Gln Gly Gly Asp Glu 235 240 245 cct ttg gac ttg tgt acc cgg aaa cgc ccc agg cac taagtgc 870 Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg His 250 255 <210> 30 <211> 258 <212> PRT <213> Simian adenovirus 39 <400> 30 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Pro Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Met Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Thr Ile Arg Ala Ala Ala Asn Gln Gly Val Lys Ala Ala Gly 130 135 140 Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val 180 185 190 Ser Asp Ala Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro 195 200 205 Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val Ala 210 215 220 Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp Leu 225 230 235 240 Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro 245 250 255 Arg His <210> 31 <211> 840 <212> DNA <213> Simian adenovirus 39 <220> <221> CDS <222> (7)..(337) <223> label=33K <220> <221> CDS <222> (507)..(835) <223> label=33K <400> 31 cccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 48 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag 96 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 144 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca 192 Asp Ser Leu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg gag gag gag aaa gca agc agc 240 Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser 65 70 75 acg gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac 288 Thr Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His 80 85 90 agt aga tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc g 337 Ser Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 95 100 105 110 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 397 gcttgcaagc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 457 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 514 Ala Pro Thr act gtt tcc aag aag agg cag aaa ccc agc agc agc agc aga aaa cca 562 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Ser Arg Lys Pro 115 120 125 gca gca gct aga aaa tcc acg gcg gca ggt gga ctg agg atc gcg gcg 610 Ala Ala Ala Arg Lys Ser Thr Ala Ala Gly Gly Leu Arg Ile Ala Ala 130 135 140 145 aac gag ccg gcg cag acc cgg gag ctg agg aac cgg atc ttt ccc acc 658 Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe Pro Thr 150 155 160 ctc tat gcc atc ttc cag cag agt cgg ggg cag gag cag gaa ctg aaa 706 Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu Leu Lys 165 170 175 gtc aag aac cgt tct ctg cgc tcg ctc acc cgc agt tgt ctg tat cac 754 Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu Tyr His 180 185 190 aag agc gaa gac caa ctt cag cgc act ctc gag gac gcc gag gct ctc 802 Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu Ala Leu 195 200 205 ttc aac aag tac tgc gcg ctc act ctt aaa gag tagcc 840 Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 32 <211> 220 <212> PRT <213> Simian adenovirus 39 <400> 32 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg 85 90 95 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro 100 105 110 Thr Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Ser Arg Lys 115 120 125 Pro Ala Ala Ala Arg Lys Ser Thr Ala Ala Gly Gly Leu Arg Ile Ala 130 135 140 Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe Pro 145 150 155 160 Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu Leu 165 170 175 Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu Tyr 180 185 190 His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu Ala 195 200 205 Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 33 <211> 36634 <212> DNA <213> Simian adenovirus 37 <220> <221> repeat_region <222> (1)..(127) <223> label=ITR <220> <221> CDS <222> (1907)..(3415) <223> label=Elb\55K <220> <221> CDS <222> (3453)..(3923) <223> label=pIX <220> <221> misc_feature <222> (3989)..(5610) <223> complement (3989..5319, 5598..5610) label=IVa2 <220> <221> misc_feature <222> (5092)..(13844) <223> complement (5092..8664, 13836..13844) label=pol <220> <221> misc_feature <222> (8467)..(13844) <223> complement (8467..10400, 13836..13844) label=pTP <220> <221> CDS <222> (10827)..(12002) <223> label=55K <220> <221> CDS <222> (12029)..(13807) <223> label=pIIIa <220> <221> CDS <222> (13889)..(15514) <223> label=penton <220> <221> CDS <222> (15521)..(16099) <223> label=pVII <220> <221> CDS <222> (16144)..(17181) <223> label=V <220> <221> CDS <222> (17209)..(17439) <223> label=pX <220> <221> CDS <222> (17512)..(18234) <223> label=pVI <220> <221> CDS <222> (18328)..(21153) <223> label=hexon <220> <221> CDS <222> (21172)..(21798) <223> label=protease <220> <221> misc_feature <222> (21883)..(23418) <223> complement label=DBP <220> <221> CDS <222> (23441)..(25840) <223> label=100K <220> <221> CDS <222> (26463)..(27143) <223> label=pVIII <220> <221> CDS <222> (27147)..(27464) <223> label=E3\12.5K <220> <221> CDS <222> (28029)..(28556) <223> label=E3\gp\19K <220> <221> CDS <222> (28593)..(29276) <223> label=E3\CR1\beta <220> <221> CDS <222> (29292)..(29900) <223> label=E3\CR1\gamma <220> <221> CDS <222> (29918)..(30781) <223> label=E3\CR1\delta <220> <221> CDS <222> (30792)..(31064) <223> label=E3\RID\alpha <220> <221> CDS <222> (31073)..(31504) <223> label=E3\RID\beta <220> <221> CDS <222> (32201)..(33535) <223> label=fiber <220> <221> misc_feature <222> (33640)..(34784) <223> complement (33640..33888, 34602..34784) label=E4\orf6/7 <220> <221> misc_feature <222> (33888)..(34784) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34763)..(35055) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (35067)..(35417) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35417)..(35803) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35856)..(36227) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36508)..(36634) <223> complement label=ITR <400> 33 catcatcaaa taatatacct caaacttttt gtgcgcgtta atatgcaaat gaggcgtttg 60 aatttgggga gggaggaagg tgattggctg cgacgaaggc gaccgttagg ggcggggcgg 120 gtgacgtttt gatgacgtgg ccatgaggcg gagccggttt gcaagttctc gtgggaaaag 180 tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac 240 aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact 300 gaatgaggaa gtgaaaatct gagtaattcc gcgtttatgg cagggaggag tatttgccga 360 gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtattt ttcacctaaa 420 tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg tgtcagctga tcgccagggt 480 atttaaacct gcgctctcta gtcaagaggc cactcttgag tgccagcgag tagagttttc 540 tcctccgcgc cgcgagtcag atctacactt tgaaagatga ggcacctgag agacctgccc 600 ggtaatgttt tcctggctac tgggaacgag attctggaac tggtggtgga cgccatgatg 660 ggtgacgacc ctcccgagcc ccctacccca tttgaggcgc cttcgctgta cgatttgtat 720 gatctggagg tggatgtgtc cgagaacgac cccaacgagg aggcggtgaa tgatttgttt 780 agcgatgccg cgctgctggc tgccgagcag gctaatacgg actctggctc agacagcgat 840 tcctctctcc ataccccgag acccggcaga ggtgagaaaa agatccccga gcttaaaggg 900 gaagagctcg acctgcgctg ctatgaggaa tgcttgcctc cgagcgatga tgaggaggac 960 gaggaggcga ttcgagctgc agcgagcgag ggagtgaaag ttgcgggcga gagctttagc 1020 ctggactgtc ctactctgcc cggacacggc tgtaagtctt gtgaatttca tcgcatgaat 1080 actggagata agaatgtgat gtgtgccctg tgctatatga gagcttacaa ccattgtgtt 1140 tacagtaagt gtgattaact ttagttggga aaggcagagg gtgactgggt gctgactggt 1200 ttatttatgt atatgttttt tatgtgtagg tcccgtctct gacgcagatg agacccccac 1260 ttcagagtgc atttcatcac ccccagaaat tggcgaggaa ccgcccgaag atattattca 1320 tagaccagtt gcagtgagag tcaccgggcg gagagcagct gtggagagtt tggatgactt 1380 gctacagggt ggggatgaac ctttggactt gtgtacccgg aaacgcccca ggcactaagt 1440 gccacacatg tgtgtttact taaggtgatg tcagtattta tagggtgtgg agtgcaataa 1500 aaatatgtgt tgactttaag tgcgtgtttt atgactcagg ggtggggact gtgggtatat 1560 aagcaggtgc agacctgtgt ggtcagttca gagcaggact tatggagatc tggacagtct 1620 tggaagactt tcaccagact agacagctgc tagagaactc atcggaggga gtctcttacc 1680 tgtggagatt ctgcttcgct gggcctctag ctaagctagt ctatagggcc aagcaggatt 1740 atagggaaca atttgaggat attttgagag agtgtcctgg tatttttgac tctctcaact 1800 tgggccatca gtctcacttt aaccagagta ttctgagagc ccttgacttt tctactcctg 1860 gcagaactac cgccgcggta gccttttttg cctttatcct tgacaa atg gag tca 1915 Met Glu Ser 1 aga aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc 1963 Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser 5 10 15 ttt gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta 2011 Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu 20 25 30 35 ctt gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc 2059 Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val 40 45 50 acc cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca 2107 Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala 55 60 65 aga gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc 2155 Arg Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser 70 75 80 ggt ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg 2203 Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 gtg ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag 2251 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 100 105 110 115 agg cat gag gag act agc cac aga act gaa ctg act gtc agt ctg atg 2299 Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met 120 125 130 agc cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtt cag tcg cag 2347 Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln 135 140 145 ggg gta gat gag gtc tcg gtg atg cat gag aaa tat tcc cta gaa caa 2395 Gly Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln 150 155 160 gtc aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc 2443 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile 165 170 175 agg aat tat gcc aag ctg gct ctg agg cca gac aag aag tac aag att 2491 Arg Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys Tyr Lys Ile 180 185 190 195 acc aaa ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg 2539 Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly 200 205 210 gcc gag gtg gag atc agt acc cag gag agg gtg gct ttc aga tgc tgc 2587 Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys 215 220 225 atg atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt 2635 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe 230 235 240 atg aac gcg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg 2683 Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met 245 250 255 gcc aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat 2731 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 260 265 270 275 aac atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc 2779 Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser 280 285 290 ttt tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg 2827 Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val 295 300 305 tca gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc 2875 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 310 315 320 gag ggc gaa gcc aaa gtc aaa cac tgc gcc tct acc gag acg ggc tgc 2923 Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 ttt gtg tgt atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt 2971 Phe Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys 340 345 350 355 ggg gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg 3019 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 360 365 370 aac agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag 3067 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys 375 380 385 aca tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac 3115 Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His 390 395 400 ctg ggc tcc cgc cga ggc atg ttc atg cca tac cag tgc aac atg caa 3163 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln 405 410 415 ttt gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg 3211 Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 420 425 430 435 gcg ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat 3259 Ala Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr 440 445 450 gat gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac 3307 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 455 460 465 gcc agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc 3355 Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro 470 475 480 gat cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg 3403 Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 gaa gaa tct gac tagagtgagt agtgtttggg ggcgggtggg agcctgc atg agg 3458 Glu Glu Ser Asp Met Arg 500 505 ggc aga atg act aaa atc tgt gtt ttt ctg tgc agc agc atg agc gga 3506 Gly Arg Met Thr Lys Ile Cys Val Phe Leu Cys Ser Ser Met Ser Gly 510 515 520 agc gcc tcc ttt gag gga ggg gta ttc agc cct tat ctg acg ggg cgt 3554 Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg 525 530 535 ctc ccc tcc tgg gcg gga gtg cgt cag aat gtg atg gga tct acg gtg 3602 Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser Thr Val 540 545 550 gac ggc cgg ccc gtg cag ccc gcg aac tct tca acc ctg acc tac gcg 3650 Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala 555 560 565 acc ctg agc tcc tcg tcc gtg gac gca gct gcc gcc gca gct gct gct 3698 Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala Ala Ala 570 575 580 585 tcc gcc gcc agc gcc gtg cgc gga atg gcc ctg ggc gcc ggc tac tac 3746 Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly Tyr Tyr 590 595 600 agc tct ctg gtg gcc aac tcg agt tcc acc aat aat ccc gcc agc ctg 3794 Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu 605 610 615 aac gag gag aag ctg ctg ctg ctg atg gcc cag ctc gag gcc ctg acc 3842 Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala Leu Thr 620 625 630 cag cgc ctg ggc gag ctg acc cag cag gtg gct cag ctg cag gcg gag 3890 Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln Ala Glu 635 640 645 acg cgg gcc gcg gtt gcc acg gtg aaa acc aaa taaaaaatga atcaataaat 3943 Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 650 655 660 aaacggagac ggttgttgat tttaacacag agtcttgaat ctttatttga tttttcgcgc 4003 gcggtaggcc ctggaccacc ggtctcgatc attgagcacc cggtggatct tttccaggac 4063 ccggtagagg tgggcttgga tgttgaggta catgggcatg agcccgtccc gggggtggag 4123 gtagctccat tgcagggcct cgtgctcggg ggtggtgttg taaatcaccc agtcatagca 4183 ggggcgcagt gcgtggtgct gcacgatgtc cttgaggagg agactgatgg ccacgggcag 4243 ccccttggtg taggtgttga cgaacctgtt gagctgggag ggatgcatgc ggggggagat 4303 gagatgcatc ttggcctgga tcttgagatt ggcgatgttc ccgcccagat cccgccgggg 4363 gttcatgttg tgcaggacca ccagcacggt gtatccggtg cacttgggga atttgtcatg 4423 caacttggaa gggaaggcgt gaaagaattt ggagacgccc ttgtgaccgc ccaggttttc 4483 catgcactca tccatgatga tggcgatggg cccgtgggcg gcggcctggg caaagacgtt 4543 tcgggggtcg gacacatcgt agttgtggtc ctgggtgagc tcgtcatagg ccattttaat 4603 gaatttgggg cggagggtgc ccgactgggg gacgaaggtg ccttcgatcc cgggggcgta 4663 gttgccctcg cagatctgca tctcccaggc cttgagctcg gaggggggga tcatgtccac 4723 ctgcggggcg atgaaaaaaa cggtttccgg ggcgggggag atgagctgcg ccgaaagcag 4783 gttccggagc agctgggact tgccgcagcc ggtggggccg tagatgaccc cgatgaccgg 4843 ctgcaggtgg tagttgaggg agagacagct gccgtcctcg cgtaggaggg gggccacctc 4903 gttcatcatc tcgcgcacat gcatgttctc gcgcacgagt tccgccagga ggcgctcgcc 4963 ccccagcgag aggagctctt gcagcgaggc gaagtttttc agcggcttga gcccgtcggc 5023 catgggcatt ttggagaggg tctgttgcaa gagttccaga cggtcccaga gctcggtgat 5083 gtgctctacg gcatctcgat ccagcagacc tcctcgtttc gcgggttggg acgactgcgg 5143 gagtagggca ccagacgatg ggcgtccagc gcagccaggg tccggtcctt ccagggtcgc 5203 agcgtccgcg tcagcgtggt ctccgtcacg gtgaaggggt gcgcgccggg ctgggcgctt 5263 gcgagggtgc gcttcaggct catccggctg gtcgagaacc gctcccgatc ggcgccctgc 5323 gcgtcggcca ggtagcaatt gaccatgagt tcgtagttga gcgcctcggc cgcgtggcct 5383 ttggcgcgga gcttaccttt ggaagtctgc ccgcaggcgg gacagaggag ggacttgagg 5443 gcgtagagct tgggggcgag gaagacggac tcgggggcgt aggcgtccgc gccgcagtgg 5503 gcgcagacgg tctcgcactc cacaagccag gtgaggtcgg ggcggtcggg gtcaaaaacg 5563 aggtttcctc cgtgcttttt gatgcgtttc ttacctctgg tctccatgag ctcgtgtccc 5623 cgctgggtga caaagaggct gtccgtgtcc ccgtagaccg actttatggg ccggtcctcg 5683 agcggggtgc cgcggtcctc gtcgtagagg aaccccgccc actccgagac gaaggcccgg 5743 gtccaggcca gcacgaagga ggccacgtgg gaggggtagc ggtcgttgtc caccagcggg 5803 tccaccttct ccagggtatg caagcacatg tccccctcgt ccacatccag gaaggtgatt 5863 ggcttgtaag tgtaggccac gtgaccgggg gtcccggccg ggggggtata aaagggggcg 5923 ggcccctgct cgtcctcact gtcttccgga tcgctgtcca ggagcgccag ctgttggggt 5983 aggtattccc tctcgaaggc gggcatgacc tcggcactca ggttgtcagt ttctagaaac 6043 gaggaggatt tgatattgac ggtgccgttg gagacgcctt tcatgagccc ctcgtccatc 6103 tggtcagaaa agacgatctt tttgttgtcg agcttggtgg cgaaggagcc gtagagggcg 6163 ttggagagca gcttggcgat ggagcgcatg gtctggttct tttccttgtc ggcgcgctcc 6223 ttggcggcga tgttgagctg cacgtactcg cgcgccacgc acttccattc ggggaagacg 6283 gtggtgagct cgtcgggcac gattctgacc cgccagccgc ggttgtgcag ggtgatgagg 6343 tccacgctgg tggccacctc gccgcgcagg ggctcgttgg tccagcagag gcgcccgccc 6403 ttgcgcgagc agaagggggg cagcgggtcc agcatgagct cgtcgggggg gtcggcgtcc 6463 acggtgaaga tgccgggcag gagctcgggg tcgaagtagc tgatgcaggt gcccagatcg 6523 tccagcgccg cttgccagtc gcgcacggcc agcgcgcgct cgtaggggct gaggggcgtg 6583 ccccagggca tggggtgcgt gagcgcggag gcgtacatgc cgcagatgtc gtagacgtag 6643 aggggctcct cgaggacgcc gatgtaggtg gggtagcagc gccccccgcg gatgctggcg 6703 cgcacgtagt cgtacagctc gtgcgagggc gcgaggagcc ccgcgccgag gttggagcgc 6763 tgcggctttt cggcgcggta gacgatctgg cggaagatgg cgtgggagtt ggaggagatg 6823 gtgggcctct ggaagatgtt gaagtgggcg tggggcaggc cgaccgagtc cctgatgaag 6883 tgggcgtagg agtcctgcag cttggcgacg agctcggcgg tgacgaggac gtccagggcg 6943 cagtagtcga gggtctcttg gatgatgtcg tacttgagct ggcccttctg cttccacagc 7003 tcgcggttga gaaggaactc ttcgcggtcc ttccagtact cttcgagggg gaacccgtcc 7063 tgatcggcac ggtaagagcc caccatgtag aactggttga cggccttgta ggcgcagcag 7123 cccttctcca cggggagggc ataagcttgc gcggccttgc gcagggaggt gtgggtgagg 7183 gcgaaggtgt cgcgcaccat gaccttgagg aactggtgct tgaagtcgag gtcgtcgcag 7243 ccgccctgct cccagagttg gaagtccgtg cgcttcttgt aggcggggtt gggcaaagcg 7303 aaagtaacat cgttgaagag gatcttgccc gcgcggggca tgaagttgcg agtgatgcgg 7363 aaaggctggg gcacctcggc ccggttgttg atgacctggg cggcgaggac gatctcgtcg 7423 aagccgttga tgttgtgccc gacgatgtag agttccacga atcgcgggcg gcccttgacg 7483 tggggcagct tcttgagctc gtcgtaggtg agctcggcgg ggtcgctgag gccgtgctgc 7543 tcaagggccc agtcggcgac gtgggggttg gcgctgagga aggaagtcca gagatccacg 7603 gccagggcgg tttgcaagcg gtcccggtac tgacggaact gctggcccac ggccattttt 7663 tcgggggtga tgcagtagaa ggtgcggggg tcgccgtgcc agcggtccca cttgagctgg 7723 agggcgaggt cgtgggcgag ctcgacgagc ggcgggtccc cggagagttt catgaccagc 7783 atgaagggga cgagctgctt gccgaaggac cccatccagg tgtaggtttc cacatcgtag 7843 gtgaggaaga gcctttcggt gcgaggatgc gagccgatgg ggaagaactg gatctcctgc 7903 caccagttgg aggaatggct gttgatgtga tggaagtaga aatgccgacg gcgcgccgag 7963 cactcgtgct tgtgtttata caagcgtccg cagtgctcgc aacgctgcac gggatgcacg 8023 tgctgcacga gctgtacctg ggttcctttg acgaggaatt tcagtgggca gtggagcgct 8083 ggcggctgca tctggtgctg tactacgtcc tggccatcgg cgtggccatc gtctgcctcg 8143 atggtggtca tgctgacgag cccgcgcggg aggcaggtcc agacctcggc tcggacgggt 8203 cggagagcga ggacgagggc gcgcaggccg gagctgtcca gggtcctgag acgctgcgga 8263 gtcaggtcag tgggcagcgg cggcgcgcgg ttgacttgca ggagcttttc cagggcgcgc 8323 gggaggtcca gatggtactt gatctccacg gcgccgttgg tggcgacgtc cacggcttgc 8383 agggtcccgt gcccctgggg cgccaccacc gtgccccgtt tcttcttggg cgctggcgtt 8443 ggcgctgctt ccatgtcggt cagaagcggc ggcgaggacg cgcgccgggc ggcaggggcg 8503 gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg ggcaggttct 8563 ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg tcctggatct 8623 gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag agttcgacag 8683 aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg tcgcccgagt 8743 tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcctga aggtctccgc 8803 ggccggcgcg ctcgacggtg gccgcgaggt cgttggagat gcggcccatg agctgcgaga 8863 aggcgttcat gccggcttcg ttccagacgc ggctgtagac cacggctccg tcggggtcgc 8923 gcgcgcgcat gaccacctgg gcgaggttga gctcgacgtg gcgcgtgaag accgcgtagt 8983 tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg acgaagaagt 9043 acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagggcttcc aaacgttcca 9103 tggcctcgta aaagtccacg gcgaagttga aaaactggga gttgcgcgcc gagacggtca 9163 actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacctcg cgctcgaagg 9223 cccccgggag ttcctccact tcctcttctt cttcctcctc cactaacatc tcttctactt 9283 cctcctcagg cggcagtggt ggcgggggag ggggcctgcg tcgccggcgg cgcacgggca 9343 gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc tcggtgacgg 9403 cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc aggtggccgg 9463 gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat tgccccgtag 9523 ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac cgttgaacga 9583 aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct ggcgggtcat 9643 gttggttgga gggagcgggg cgggcgatgc tgctggtgat gaagttgaaa taggcggttc 9703 tgagacggcg gatggtggcg aggagcacca ggtccttggg cccggcttgc tggatgcgca 9763 gacggtcggc catgccccag gcgtggtcct gacacctggc gaggtccttg tagtagtcct 9823 gcatgagccg ctccacgggc acctcctcct cgcccgcgcg gccgtgcatg cgcgtgagcc 9883 cgaacccgcg ctgcggctgg acgagcgcca ggtcggcgac gacgcgctcg gcgaggatgg 9943 cctgctggat ctgggtgagg gtggtctgga agtcgtcgaa gtcgacgaag cggtggtagg 10003 ctccggtgtt gatggtgtag gagcagttgg ccatgacgga ccagttgacg gtctggtggc 10063 ccggacgcac gagctcgtgg tacttgaggc gcgagtaggc gcgcgtgtcg aagatgtagt 10123 cgttgcaggt gcgcaccagg tactggtagc cgatgaggaa gtgcggcggc ggctggcggt 10183 agagcggcca tcgctcggtg gcgggggcgc cgggcgcgag gtcctcgagc atgaggcggt 10243 ggtagccgta gatgtacctg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg 10303 ggaactcgcg gacgcggttc cagatgttgc gcagcggcag gaagtagttc atggtgggca 10363 cggtctggcc cgtgaggcgc gcgcagtcgt ggatgctcta tacgggcaaa aacgaaagcg 10423 gtcagcggct cgactccgtg gcctggaggc taagcgaacg ggttgggctg cgcgtgtacc 10483 ccggttcgaa tctcgaatca ggctggagcc gcagctaacg tggtactggc actcccgtct 10543 cgacccaagc ctgcaccaac cctccaggat acggaggcgg gtcgttttgc aatttttttc 10603 ggaggccgga gactagtaag cgcggaaagc ggccgaccgc gatggctcgc tgccgtagtc 10663 tggagaagaa tcgccagggt tgcgttgcgg tgtgccccgg ttcgaggccg gccggattcc 10723 gcggctaacg agggcgtggc tgccccgtcg tttccaagac ccctagccag ccgacttctc 10783 cagttacgga gcgagcccct cttttgtttt ttgtttttgc cag atg cat ccc gta 10838 Met His Pro Val ctg cgg cag atg cgc ccc cac cac cct cca ccg caa caa cag ccc cct 10886 Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro 665 670 675 680 cca cag ccg gcg ctt ctg ccc ccg ccc cag cag caa ctt cca gcc acg 10934 Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Leu Pro Ala Thr 685 690 695 acc gcc gcg gcc gcc gtg agc ggg gct gga cag agt tat gac cac cag 10982 Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Ser Tyr Asp His Gln 700 705 710 ctg gcc ttg gaa gag ggc gag ggg ctg gcg cgc ctg ggg gcg tcg tcg 11030 Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser 715 720 725 ccg gag cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc 11078 Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala 730 735 740 tac gtg ccc aag cag aac ctg ttc aga gac agg agc ggc gag gag ccc 11126 Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro 745 750 755 760 gag gag atg cgc gcg gcc cgg ttc cac gcg ggg cgg gag ctg cgg cgc 11174 Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg 765 770 775 ggc ctg gac cga aag agg gtg ctg agg gac gag gat ttc gag gcg gac 11222 Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp 780 785 790 gag ctg acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac 11270 Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn 795 800 805 ctg gtc acg gcg tac gag cag acc gtg aag gag gag agc aac ttc caa 11318 Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln 810 815 820 aaa tcc ttc aac aac cac gtg cgc acg ctg atc gcg cgc gag gag gtg 11366 Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val 825 830 835 840 acc ctg ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc gtg cag 11414 Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln 845 850 855 aac ccc acg agc aag ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag 11462 Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln 860 865 870 cac agt cgg gac aac gag acg ttc agg gag gcg ctg ctg aat atc acc 11510 His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr 875 880 885 gag ccc gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg cag agc 11558 Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser 890 895 900 atc gtg gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc 11606 Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala 905 910 915 920 atc aac ttc tcg gtg ctg agt ttg ggc aag tac tac gct agg aag atc 11654 Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile 925 930 935 tac aag acc ccg tac gtg ccc ata gac aag gag gtg aag atc gac ggg 11702 Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly 940 945 950 ttt tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg 11750 Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu 955 960 965 ggg gtg tac cgc aac gac agg atg cac cgt gcg gtg agc gcc agc cgc 11798 Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg 970 975 980 cgg cgc gag ctg agc gac cag gag ctg atg cac agc ctg cag cgg gcc 11846 Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala 985 990 995 1000 ctg acc ggg gcc ggg acc gag ggg gag agc tac ttt gac atg ggc 11891 Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly 1005 1010 1015 gcg gac ctg cgc tgg cag ccc agc cgc cgg gcc ttg gaa gct gcc 11936 Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala 1020 1025 1030 ggc ggt tcc ccc tac gta gaa gag gtg gac gat gag gtg gac gag 11981 Gly Gly Ser Pro Tyr Val Glu Glu Val Asp Asp Glu Val Asp Glu 1035 1040 1045 gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag atg caa 12034 Glu Gly Glu Tyr Leu Glu Asp Met Gln 1050 caa cag cca cct cct gat ccc gcg atg cgg gcg gcg ctg cag agc 12079 Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser 1055 1060 1065 cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc atg 12124 Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 1070 1075 1080 caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa gcc ttt aga 12169 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 1085 1090 1095 cag cag ccc cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg 12214 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val 1100 1105 1110 gtg ccc tcg cgc tcc aac ccc acg cac gag aag gtc ctg gcc atc 12259 Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile 1115 1120 1125 gtg aac gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc 12304 Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala 1130 1135 1140 ggc ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac 12349 Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn 1145 1150 1155 agc acc aac gtg cag acc aac ctg gac cgc atg gtg acc gac gtg 12394 Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val 1160 1165 1170 cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc gag tcc aac 12439 Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg Glu Ser Asn 1175 1180 1185 ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc acc cag ccc 12484 Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 1190 1195 1200 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc agc 12529 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser 1205 1210 1215 gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc gag gtg tac 12574 Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser Glu Val Tyr 1220 1225 1230 cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg 12619 Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu 1235 1240 1245 cag acc gtg aac ctg agc cag gct ttc aag aac ttg cag gga ttg 12664 Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu 1250 1255 1260 tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc 12709 Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser 1265 1270 1275 ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcc ccc 12754 Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro 1280 1285 1290 ttc acg gac agc ggc agc atc aac cgc aac tcg tac ctg ggc tac 12799 Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly Tyr 1295 1300 1305 ctg att aac ctg tac cgc gag gcc atc ggc cag gcg cac gtg gac 12844 Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 1310 1315 1320 gag cag acc tac cag gag atc acc cac gtg agc cgc gcc ctg ggc 12889 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 1325 1330 1335 cag gac gac ccg ggc aac ctg gaa gcc acc ctg aac ttt ttg ctg 12934 Gln Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu 1340 1345 1350 acc aac cgg tcg cag aag atc ccg ccc cag tac gcg ctc agc acc 12979 Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr 1355 1360 1365 gag gag gag cgc atc ctg cgt tac gtg cag cag agc gtg ggc ctg 13024 Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu 1370 1375 1380 ttc ctg atg cag gag ggg gcc acc ccc agc gcc gcg ctc gac atg 13069 Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met 1385 1390 1395 acc gcg cgc aac atg gag ccc agc atg tac gcc agc aac cgc ccg 13114 Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro 1400 1405 1410 ttc atc aat aaa ctg atg gac tac ttg cat cgg gcg gcc gcc atg 13159 Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met 1415 1420 1425 aac tct gac tat ttc acc aac gcc atc ctg aat ccc cac tgg ctc 13204 Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu 1430 1435 1440 ccg ccg cct ggg ttc tac acg ggc gag tac gac atg ccc gac ccc 13249 Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro 1445 1450 1455 aat gac ggg ttc ctg tgg gac gat gtg gac agc agc gtg ttc tcc 13294 Asn Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser 1460 1465 1470 ccc cga ccg ggt gct aac gag cgc ccc ttg tgg aag aag gaa ggc 13339 Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu Trp Lys Lys Glu Gly 1475 1480 1485 agc gac cga cgc ccg tcc tcg gcg ctg tcc ggc cgc gag ggt gct 13384 Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Glu Gly Ala 1490 1495 1500 gcc gcg gcg gtg ccc gag gcc gcc agt cct ttt cct agc ttg ccc 13429 Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro 1505 1510 1515 ttc tcg ctg aac agt atc cgc agc agc gag ctg ggg agg atc acg 13474 Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr 1520 1525 1530 cgc ccg cgc ttg ctg ggc gag gag gag tac ttg aat gac tcg ctg 13519 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu 1535 1540 1545 ttg aga ccc gag cgg gag aag aac ttc ccc aat aac ggg ata gag 13564 Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 1550 1555 1560 agc ctg gtg gac aag atg agc cgc tgg aag acg tat gcg cag gag 13609 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu 1565 1570 1575 cac agg gac gat ccc cgg gcg tcg cag ggg gcc acg agc cgg ggc 13654 His Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Thr Ser Arg Gly 1580 1585 1590 agc gcc gcc cgt aaa cgc cgg tgg cac gac agg cag cgg gga ctg 13699 Ser Ala Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu 1595 1600 1605 atg tgg gac gat gag gat tcc gcc gac gac agc agc gtg ttg gac 13744 Met Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp 1610 1615 1620 ttg ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ctg cgc ccc 13789 Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro 1625 1630 1635 cgc atc ggg cgc atg atg taagaaaccg aaaataaatg atactcacca 13837 Arg Ile Gly Arg Met Met 1640 1645 aggccatggc gaccagcgtg cgttcgtttc ttctctgttg ttgtatctag t atg atg 13894 Met Met agg cgt gcg tac ccg gag ggt cct cct ccc tcg tac gag agc gtg 13939 Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser Val 1650 1655 1660 atg cag cag gcg atg gcg gcg gcg gcg gcg atg cag ccc ccg ctg 13984 Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 1665 1670 1675 gag gct cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg 14029 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly 1680 1685 1690 cgg aac agc att cgt tac tcg gag ctg gca ccc ttg tac gat acc 14074 Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr 1695 1700 1705 acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg 14119 Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser 1710 1715 1720 ctg aac tac cag aac gac cac agc aac ttc ctg acc acc gtg gtg 14164 Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 1725 1730 1735 cag aac aat gac ttc acc ccc acg gag gcc agc acc cag acc atc 14209 Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile 1740 1745 1750 aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc 14254 Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile 1755 1760 1765 atg cac acc aac atg ccc aac gtg aac gag ttc atg tac agc aac 14299 Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn 1770 1775 1780 aag ttc aag gcg cgg gtc atg gtc tcc cgc aag acc ccc aac ggg 14344 Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly 1785 1790 1795 gtc aag gta gat gat acg tat gat ggt agt cag gat gag cta aaa 14389 Val Lys Val Asp Asp Thr Tyr Asp Gly Ser Gln Asp Glu Leu Lys 1800 1805 1810 tac gag tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc tcg gtg 14434 Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val 1815 1820 1825 acc atg acc atc gac ctg atg aac aac gcc atc atc gac aat tac 14479 Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 1830 1835 1840 ttg gcg gtg ggg cgg cag aac ggg gtg ttg gag agc gac atc ggc 14524 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly 1845 1850 1855 gtg aag ttc gac act agg aac ttc agg ctg ggc tgg gac ccc gtg 14569 Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 1860 1865 1870 acc gag ctg gtc atg ccc ggg gtg tac acc aac gag gcc ttc cat 14614 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 1875 1880 1885 ccc gat att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc acc gag 14659 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu 1890 1895 1900 agc cgc ctc agc aac ctg ctg ggc att cgc aaa agg cag ccc ttc 14704 Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 1905 1910 1915 cag gag ggc ttc cag atc atg tac gag gat ctg gag ggg ggc aac 14749 Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn 1920 1925 1930 atc ccc gcc ctc ctg gat gtc gag gcc tat gag gac agt aag aaa 14794 Ile Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Asp Ser Lys Lys 1935 1940 1945 aaa gca gaa gcc gag gcg act gca gcc gtg gct acc gcc gcg acc 14839 Lys Ala Glu Ala Glu Ala Thr Ala Ala Val Ala Thr Ala Ala Thr 1950 1955 1960 aat gca gat gcc aat gtg act aga ggc gat aca ttc gcc act cag 14884 Asn Ala Asp Ala Asn Val Thr Arg Gly Asp Thr Phe Ala Thr Gln 1965 1970 1975 gcg gag gaa gca gcc gcc cta gcg gtc gcc gat gat agt gaa agt 14929 Ala Glu Glu Ala Ala Ala Leu Ala Val Ala Asp Asp Ser Glu Ser 1980 1985 1990 aag ata gtc att cag ccg gtg aag aag gat agc aag aac agg agc 14974 Lys Ile Val Ile Gln Pro Val Lys Lys Asp Ser Lys Asn Arg Ser 1995 2000 2005 tac aac gtg ctg ccg gac gag gta aac acc gcc tac cgc agc tgg 15019 Tyr Asn Val Leu Pro Asp Glu Val Asn Thr Ala Tyr Arg Ser Trp 2010 2015 2020 tac ctg gcc tac aac tat ggc gac ccc gag aag ggc gtg cgc tcc 15064 Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser 2025 2030 2035 tgg acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg gag caa 15109 Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln 2040 2045 2050 gtc tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc acc ttc 15154 Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe 2055 2060 2065 cgc tcc acg cgt caa gtt agc aac tac ccg gtg gtg ggc gcc gag 15199 Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu 2070 2075 2080 ctc ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag gcc gtc 15244 Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val 2085 2090 2095 tac tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc 15289 Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe 2100 2105 2110 aac cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc gcg ccc 15334 Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro 2115 2120 2125 acc att acc acc gtc agt gaa aac gtt cct gct ctc aca gat cac 15379 Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His 2130 2135 2140 ggg acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag cgc gtg 15424 Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 2145 2150 2155 acc gtt act gac gcc aga cgc cgc acc tgc ccc tac gtc tac aag 15469 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys 2160 2165 2170 gcc ctg ggc ata gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc 15514 Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 2175 2180 2185 taaaaa atg tcc att ctc atc tcg ccc agt aat aac acc ggt tgg ggc 15562 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly 2190 2195 2200 ctg cgc gcg ccc agc aag atg tac gga ggc gct cgc caa cgc tcc 15607 Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser 2205 2210 2215 acg caa cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct ccc tgg 15652 Thr Gln His Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp 2220 2225 2230 ggc gcc ctc aag ggc cgc gtg cgg tcg cgc acc acc gtc gac gac 15697 Gly Ala Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp 2235 2240 2245 gtg atc gac cag gtg gtg gcc gac gcg cgc aac tac acc ccc gcc 15742 Val Ile Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala 2250 2255 2260 gcc gcg ccc gtc tcc acc gtg gac gcc gtc atc gac agc gtg gtg 15787 Ala Ala Pro Val Ser Thr Val Asp Ala Val Ile Asp Ser Val Val 2265 2270 2275 gcc gac gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg cgg cgc 15832 Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg 2280 2285 2290 atc gcc cgg cgg cac cgg agc acc ccc gcc atg cgc gcg gcg cga 15877 Ile Ala Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala Ala Arg 2295 2300 2305 gcc ttg ctg cgc agg gcc agg cgc acg gga cgc agg gcc atg ctc 15922 Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala Met Leu 2310 2315 2320 agg gcg gcc aga cgc gcg gct tca ggc gcc agc gcc ggc agg acc 15967 Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala Ser Ala Gly Arg Thr 2325 2330 2335 cgg aga cgc gcg gcc acg gcg gcg gca gcg gcc atc gcc agc atg 16012 Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser Met 2340 2345 2350 tcc cgc ccg cgg cga ggg aac gtg tac tgg gtg cgc gac gcc gcc 16057 Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg Asp Ala Ala 2355 2360 2365 acc ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct cgc act 16099 Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg Thr 2370 2375 2380 tgaagatgtt cacttcgcga tgttgatgtg tcccagcggc gagg atg tcc aag cgc 16155 Met Ser Lys Arg aaa ttc aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac 16200 Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr 2385 2390 2395 ggc ccc gcg gcg gtg gtg aag gag gaa aga aag ccc cgc aaa atc 16245 Gly Pro Ala Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys Ile 2400 2405 2410 aag cgg gtc aaa aag gac aaa aag gaa gaa gat gtg gac gat atg 16290 Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp Met 2415 2420 2425 gtg gag ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg 16335 Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 2430 2435 2440 cgc ggg cgg aag gtg cgc ccg gtg ctg aga ccc ggc acc acc gtg 16380 Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val 2445 2450 2455 gtc ttc acg ccc ggc gag cgc tcc ggc acc gct tcc aag cgc tcc 16425 Val Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser 2460 2465 2470 tac gac gag gtg tac ggg gat gat gat att ctg gag cag gcg gcc 16470 Tyr Asp Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala 2475 2480 2485 gag cgc ctg ggc gag ttt gct tac ggc aag cgc agc cgc ccc gcg 16515 Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala 2490 2495 2500 ccc ttg aaa gag gag gcg gtg tcc atc ccg ctg gac cac ggc aac 16560 Pro Leu Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn 2505 2510 2515 ccc acg ccg agc ctg aag ccg gtg acc ctg cag cag gtg ctg ccg 16605 Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro 2520 2525 2530 agc gcg gcg ccg cgc cgg ggc ttc aag cgc gag ggc ggc gag gat 16650 Ser Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Gly Glu Asp 2535 2540 2545 ctg tac ccg acc atg cag ctg atg gtg ccc aag cgc cag aag ctg 16695 Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu 2550 2555 2560 gag gac gtg ctg gag cac atg aag gtg gac ccc gag gtg cag ccc 16740 Glu Asp Val Leu Glu His Met Lys Val Asp Pro Glu Val Gln Pro 2565 2570 2575 gag gtc aag gtg cgg ccc atc aag cag gtg gcc ccg ggc ctg ggc 16785 Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly 2580 2585 2590 gtg cag acc gtg gac atc aag atc ccc acg gag ccc atg gaa acg 16830 Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr 2595 2600 2605 cag acc gag ccc gtg aag ccc agc acc agc acc atg gag gtg cag 16875 Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln 2610 2615 2620 acg gat ccc tgg atg ccg gcg ccg gct tcc acc acc act cgc cga 16920 Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr Thr Arg Arg 2625 2630 2635 aga cgc aag tac ggc gcg gcc agc ctg ctg atg ccc aac tac gcg 16965 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala 2640 2645 2650 ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc ggc acg cgc 17010 Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 2655 2660 2665 ttc tac cgc ggc tac agc agc cgc cgc aag acc acc acc cgc cgc 17055 Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg 2670 2675 2680 cgc cgt cgc cgc acc cgc cgc agc acc acc gcg act tcc gcc gcc 17100 Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala 2685 2690 2695 gcc ttg gtg cgg aga gtg tac cgc agc ggg cgt gag cct ctg acc 17145 Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 2700 2705 2710 ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att taactctgcc 17191 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2715 2720 2725 gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc gtc ccc att 17241 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile 2730 2735 acg ggc tac cga gga aga aag ccg cgc cgt aga agg ctg acg ggg 17286 Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly 2740 2745 2750 aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc gcc atc agc 17331 Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg Ala Ile Ser 2755 2760 2765 aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc ccc atc atc 17376 Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile 2770 2775 2780 gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc gtg gcg gtg 17421 Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser Val Ala Val 2785 2790 2795 cag gcc tct cag cgc cac tgagacacag cttggaaaat ttgtaataaa 17469 Gln Ala Ser Gln Arg His 2800 aaaatggact gacgctcctg gtcctgtgat gtgtgttttt ag atg gaa gac atc 17523 Met Glu Asp Ile 2805 aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg ttt atg 17568 Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met 2810 2815 2820 ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg ggc gcc 17613 Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly Gly Ala 2825 2830 2835 ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc 17658 Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 2840 2845 2850 acg ctc aaa acc tat ggc aac aag gcg tgg aac agc agc aca ggg 17703 Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 2855 2860 2865 cag gcg ctg agg gaa aag ctg aaa gag cag aac ttc cag cag aag 17748 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys 2870 2875 2880 gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg gtg gtg gac ctg 17793 Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu 2885 2890 2895 gcc aac cag gcc gtg cag aaa cag atc aac agc cgc ctg gac gcg 17838 Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala 2900 2905 2910 gtc ccg ccc gcg ggg tcc gtg gag atg ccc cag gtg gag gag gag 17883 Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu 2915 2920 2925 ctg cct ccc ctg gac aag cgc ggc gac aag cga ccg cgt ccc gac 17928 Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp 2930 2935 2940 gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc ccg tac 17973 Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr 2945 2950 2955 gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc gtg gcg 18018 Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Val Ala 2960 2965 2970 cct ctg gcc acc ggg gtg ctg aaa ccc agc agc agc agc agc cag 18063 Pro Leu Ala Thr Gly Val Leu Lys Pro Ser Ser Ser Ser Ser Gln 2975 2980 2985 ccc gcg acc ctg gac ttg cct cca cct cgc ccc tcc aca gtg gct 18108 Pro Ala Thr Leu Asp Leu Pro Pro Pro Arg Pro Ser Thr Val Ala 2990 2995 3000 aag ccc ctg ccg ccg gtg gcc gtc gcg tcg cgc gcc ctc cga ggc 18153 Lys Pro Leu Pro Pro Val Ala Val Ala Ser Arg Ala Leu Arg Gly 3005 3010 3015 cgc ccc cag gcg aac tgg cag agc act ctg aac agc atc gtg ggt 18198 Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly 3020 3025 3030 ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaaagacac 18244 Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 3035 3040 tgtagcgctt aacttgcttg tctgtgtgta tgtatgtccg ccgaccagaa ggaggaggaa 18304 gaggcgcgtc gccgagttgc aag atg gcc acc cca tcg atg ctg ccc cag 18354 Met Ala Thr Pro Ser Met Leu Pro Gln 3045 3050 tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg 18399 Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu 3055 3060 3065 agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc 18444 Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe 3070 3075 3080 agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac 18489 Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His 3085 3090 3095 gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg 18534 Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val 3100 3105 3110 ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac 18579 Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr 3115 3120 3125 acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc 18624 Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr 3130 3135 3140 tac ttt gac atc cgc ggc gtg ctg gat cgg ggc ccc agc ttc aaa 18669 Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys 3145 3150 3155 ccc tac tcc ggc acc gcc tac aac agc ctg gct ccc aag gga gct 18714 Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala 3160 3165 3170 ccc aat tcc agc cag tgg gag caa gca aaa aca ggc aat ggg gga 18759 Pro Asn Ser Ser Gln Trp Glu Gln Ala Lys Thr Gly Asn Gly Gly 3175 3180 3185 act atg gaa aca cac aca tat ggt gtg gcc cca atg ggc gga gag 18804 Thr Met Glu Thr His Thr Tyr Gly Val Ala Pro Met Gly Gly Glu 3190 3195 3200 aat att aca aaa gat ggt ctt caa att gga act gac gtt aca gcg 18849 Asn Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Asp Val Thr Ala 3205 3210 3215 aat cag aat aaa cca att tat gcc gac aaa aca ttt caa cca gaa 18894 Asn Gln Asn Lys Pro Ile Tyr Ala Asp Lys Thr Phe Gln Pro Glu 3220 3225 3230 ccg caa gta gga gaa gaa aat tgg caa gaa act gaa aac ttt tat 18939 Pro Gln Val Gly Glu Glu Asn Trp Gln Glu Thr Glu Asn Phe Tyr 3235 3240 3245 ggc ggt aga gct ctt aaa aaa gac aca aac atg aaa cct tgc tat 18984 Gly Gly Arg Ala Leu Lys Lys Asp Thr Asn Met Lys Pro Cys Tyr 3250 3255 3260 ggc tcc tat gct aga ccc acc aat gaa aaa gga ggt caa gct aaa 19029 Gly Ser Tyr Ala Arg Pro Thr Asn Glu Lys Gly Gly Gln Ala Lys 3265 3270 3275 ctt aaa gtt gga gat gat gga gtt cca acc aaa gaa ttc gac ata 19074 Leu Lys Val Gly Asp Asp Gly Val Pro Thr Lys Glu Phe Asp Ile 3280 3285 3290 gac ctg gct ttc ttt gat act ccc ggt ggc acc gtg aac ggt caa 19119 Asp Leu Ala Phe Phe Asp Thr Pro Gly Gly Thr Val Asn Gly Gln 3295 3300 3305 gac gag tat aaa gca gac att gtc atg tat acc gaa aac acg tat 19164 Asp Glu Tyr Lys Ala Asp Ile Val Met Tyr Thr Glu Asn Thr Tyr 3310 3315 3320 ctg gaa act cca gac acg cat gtg gta tac aaa cca ggc aag gat 19209 Leu Glu Thr Pro Asp Thr His Val Val Tyr Lys Pro Gly Lys Asp 3325 3330 3335 gat gca agt tct gaa att aac ctg gtt cag cag tct atg ccc aac 19254 Asp Ala Ser Ser Glu Ile Asn Leu Val Gln Gln Ser Met Pro Asn 3340 3345 3350 aga ccc aac tac att ggg ttc agg gac aac ttt atc ggt ctt atg 19299 Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met 3355 3360 3365 tac tac aac agt act ggc aat atg ggt gtg ctt gct ggt cag gcc 19344 Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala 3370 3375 3380 tcc cag ctg aat gct gtg gtt gac ttg caa gac aga aac aca gag 19389 Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu 3385 3390 3395 ctg tcc tac cag ctc ttg ctt gac tct ttg ggt gac aga acc agg 19434 Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg 3400 3405 3410 tat ttc agt atg tgg aat cag gcg gtg gac agt tat gat cct gat 19479 Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp 3415 3420 3425 gtg cgc att att gaa aac cat ggt gtg gaa gat gaa ctt ccc aac 19524 Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn 3430 3435 3440 tat tgc ttc ccc ctg gat ggg tct ggc act aac gcc gct tac caa 19569 Tyr Cys Phe Pro Leu Asp Gly Ser Gly Thr Asn Ala Ala Tyr Gln 3445 3450 3455 ggt gtg aaa gta aaa aat ggt caa gat ggt gat gtt gag agc gaa 19614 Gly Val Lys Val Lys Asn Gly Gln Asp Gly Asp Val Glu Ser Glu 3460 3465 3470 tgg gaa aaa gat gat act gtc gca gct caa aat caa tta tgt aaa 19659 Trp Glu Lys Asp Asp Thr Val Ala Ala Gln Asn Gln Leu Cys Lys 3475 3480 3485 ggt aac att ttt gcc atg gag atc aat ctc cag gct aac ctg tgg 19704 Gly Asn Ile Phe Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp 3490 3495 3500 aga agt ttc ctc tac tcg aac gtg gcc ctg tac ctg ccc gac tcc 19749 Arg Ser Phe Leu Tyr Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser 3505 3510 3515 tac aag tac acg ccg acc aac gtc acg ctg ccg acc aac acc aac 19794 Tyr Lys Tyr Thr Pro Thr Asn Val Thr Leu Pro Thr Asn Thr Asn 3520 3525 3530 acc tac gat tac atg aac ggg aga gtg aca cct ccc tcg ctg gta 19839 Thr Tyr Asp Tyr Met Asn Gly Arg Val Thr Pro Pro Ser Leu Val 3535 3540 3545 gac gcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac ccc atg 19884 Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met 3550 3555 3560 gac aac gtc aat ccc ttc aac cac cat cgc aac gcg ggg ctg cgc 19929 Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg 3565 3570 3575 tac cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg ccc ttc cac 19974 Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His 3580 3585 3590 atc cag gtg ccc cag aaa ttt ttc gcc att aag agc ctc ctg ctc 20019 Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu 3595 3600 3605 ctg ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag gac gtc 20064 Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val 3610 3615 3620 aac atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc acg gac 20109 Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp 3625 3630 3635 ggg gcc tcc atc tcc ttc acc agc atc aac ctc tac gca acc ttc 20154 Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe 3640 3645 3650 ttc ccc atg gcg cac aac acg gct tcc acg ctc gag gcc atg ctg 20199 Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu 3655 3660 3665 cgc aac gac acc aac gac cag tcc ttc aac gac tac ctc tcg gcg 20244 Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala 3670 3675 3680 gcc aac atg ctc tac ccc atc ccg gcc aac gcc acc aac gtg ccc 20289 Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro 3685 3690 3695 atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc 20334 Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser 3700 3705 3710 ttc acg cgc ctc aag acc aag gag acg ccc tcg ctg ggc tcc ggg 20379 Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly 3715 3720 3725 ttc gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac ctc gac 20424 Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp 3730 3735 3740 ggc acc ttc tac ctc aac cac acc ttc aag aag gtc tcc atc acc 20469 Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr 3745 3750 3755 ttc gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc ctg acg 20514 Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr 3760 3765 3770 ccc aac gag ttc gaa atc aag cgc acc gtc gac ggc gag ggc tac 20559 Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr 3775 3780 3785 aac gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg gtc cag 20604 Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln 3790 3795 3800 atg ctg gcc cac tac aac atc ggc tac cag ggc ttc tac gtg ccc 20649 Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro 3805 3810 3815 gag ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac ttc cag 20694 Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln 3820 3825 3830 ccc atg agc cgc cag gtg gtg gac gag gtc aac tac aag gac tac 20739 Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr 3835 3840 3845 cag gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc ttc gtc 20784 Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val 3850 3855 3860 ggc tac ctc gcg ccc acc atg cgc cag ggc cag ccc tac ccc gcc 20829 Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala 3865 3870 3875 aac tac ccc tac ccg ctc atc ggc aag agc gcc gtc acc agc gtc 20874 Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val 3880 3885 3890 acc cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc atc ccc 20919 Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro 3895 3900 3905 ttc tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac ctc ggc 20964 Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly 3910 3915 3920 cag aac atg ctc tat gcc aac tcc gcc cac gcg cta gac atg aat 21009 Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn 3925 3930 3935 ttc gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat gtt gtc 21054 Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val 3940 3945 3950 ttc gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac cgc ggc 21099 Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly 3955 3960 3965 gtc atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc ggt aac 21144 Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn 3970 3975 3980 gcc acc acc taagctcttg cttcttgc atg atg gct gag ccc acg ggc tcc 21195 Ala Thr Thr Met Met Ala Glu Pro Thr Gly Ser 3985 3990 ggc gag cag gag ctc agg gcc atc atc cgc gac ctg ggc tgc ggg 21240 Gly Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly 3995 4000 4005 ccc tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga ttc atg 21285 Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met 4010 4015 4020 gcc ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc ggc cgc 21330 Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg 4025 4030 4035 gag acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc 21375 Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg 4040 4045 4050 tcg aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg gac gag 21420 Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu 4055 4060 4065 cgc ctc aag cag atc tac cag ttc gag tac gag ggc ctg ctg cgc 21465 Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg 4070 4075 4080 cgt agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag 21510 Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 4085 4090 4095 tcc acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc 21555 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 4100 4105 4110 ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc 21600 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg 4115 4120 4125 ccc atg gac aag aac ccc acc atg aac tta ctg acg ggg gtg ccc 21645 Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro 4130 4135 4140 aac ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg cgc cgc 21690 Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg 4145 4150 4155 aac cag gag gcg ctc tac cgc ttc ctc aac gcc cac tcc gcc tac 21735 Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr 4160 4165 4170 ttt cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac 21780 Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp 4175 4180 4185 cgc atg aat caa gac atg taaaccgtgt gtgtatgtga atgctttatt 21828 Arg Met Asn Gln Asp Met 4190 4195 cataataaac agcacatgtt tatgccacct tctctgaggc tctgacttta tttagaaatc 21888 gaaggggttc tgccggctct cggcgtgccc cgcgggcagg gatacgttgc ggaactggta 21948 cttgggcagc cacttgaact cggggatcag cagcttcggc acggggaggt cggggaacga 22008 gtcgctccac agcttgcgcg tgagttgcag ggcgcccagc aggtcgggcg cggagatctt 22068 gaaatcacag ttgggacccg cgttctgcgc gcgagagttg cggtacacgg ggttgcagca 22128 ctggaacacc atcagggccg ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc 22188 ctccacgtcc agatcctcgg cgttggccat cccgaagggg gtcatcttgc aggtctgccg 22248 ccccatgctg ggcacgcagc cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat 22308 catctgggcc tgttcggagc tcatgcccgg gtacatggcc ttcatgaaag cctccagctg 22368 gcggaaggcc tgctgcgcct tgccgccctc ggtgaagaag accccgcagg acttgctaga 22428 gaactggttg gtagcgcagc ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag 22488 ctgcaccacg ctgcgccccc agcggttctg ggtgatcttg gcccggtcgg ggttctcctt 22548 cagcgcgcgc tgcccgttct cgctcgccac atccatctcg atcgtgtgct ccttctggat 22608 catcacggtc ccgtgcaggc accgcagctt gccctcggcc tcggtgcagc cgtgcagcca 22668 cagcgcgcag ccggtgctct cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa 22728 gccctgcagg aagcggccca tcatcgtggt cagggtcttg ttgctggtga aggtcagcgg 22788 gatgccgcgg tgctcctcgt tcacatacat gtggcagatg cggcggtaca cctcgccctg 22848 ctcgggcatc agctggaagg cggacttcag gtcgctctcc acgcggtacc ggtccatcag 22908 cagcgtcatg acttccatgc ccttctccca ggccgaaacg atcggcaggc tcagggggtt 22968 cttcaccgcc attgtcatct tagtcgccgc cgccgaggtc agggggtcgt tctcgtccag 23028 ggtctcaaac actcgcttgc cgtccttctc ggtgatgcgc acggggggga aggcgaagcc 23088 cacggccgcc agctcctcct cggcctgcct ttcgtcctcg ctgtcctggc tgatgtcttg 23148 caaaggcaca tgcttggtct tgcggggttt ctttttgggc ggcagaggcg gcggcgatgt 23208 gctgggcgag cgcgagttct cgctcaccac gactatttct tctccttggc cgtcgtccga 23268 gaccacgcgg cggtaggcat gcctcttctg gggcagaggc ggaggcgacg ggctctcgcg 23328 gttcggcggg cggctggcag agccccttcc gcgttcgggg gtgcgctcct ggcggcgctg 23388 ctctgactga cttcctccgc ggccggccat tgtgttctcc tagggagcaa gc atg gag 23446 Met Glu act cag cca tcg tcg cca aca tcg cca tct gcc ccc gcc gcc acc 23491 Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Thr 4200 4205 4210 gcc gac gag aac cag cag cag cag aat gaa agc tta acc gcc ccg 23536 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro 4215 4220 4225 ccg ccc agc ccc acc tcc gac gcc gcg gcc cca gac atg caa gag 23581 Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu 4230 4235 4240 atg gag gaa tcc atc gag att gac ctg ggc tac gtg acg ccc gcg 23626 Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala 4245 4250 4255 gag cac gag gag gag ctg gca gcg cgc ttt tca gcc ccg gaa gaa 23671 Glu His Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu 4260 4265 4270 aac cac caa gag cag cca gag cag gaa gca gag agc gag cag aac 23716 Asn His Gln Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Asn 4275 4280 4285 cag gct ggg ctc gag cat ggc gac tac ctg agc ggg gca gag gac 23761 Gln Ala Gly Leu Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp 4290 4295 4300 gtg ctc atc aag cat ctg gcc cgc caa tgc atc atc gtc aag gac 23806 Val Leu Ile Lys His Leu Ala Arg Gln Cys Ile Ile Val Lys Asp 4305 4310 4315 gcg ctg ctc gac cgc gcc gag gtg ccc ctc agc gtg gcg gag ctc 23851 Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser Val Ala Glu Leu 4320 4325 4330 agc cgc gcc tac gag cgc aac ctc ttc tcg cca cgc gtg ccc ccc 23896 Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro Pro 4335 4340 4345 aag cgc cag ccc aac ggc acc tgt gag ccc aac ccg cgc ctc aac 23941 Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn 4350 4355 4360 ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac 23986 Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His 4365 4370 4375 ctc ttt ttc aag aac caa agg atc ccc gtc tcc tgc cgc gcc aac 24031 Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser Cys Arg Ala Asn 4380 4385 4390 cgc acc cgc gcc gac gcc ctg ctc aac ctg ggc ccc ggc gcc cgc 24076 Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg 4395 4400 4405 cta cct gat atc acc tcc ttg gaa gag gtt ccc aag atc ttt gag 24121 Leu Pro Asp Ile Thr Ser Leu Glu Glu Val Pro Lys Ile Phe Glu 4410 4415 4420 ggt ctg ggc agc gac gag act cgg gcc gcg aac gct ctg caa gga 24166 Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly 4425 4430 4435 agc gga gag gag cat gag cac cac agc gcc ctg gtg gag ttg gaa 24211 Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu 4440 4445 4450 ggc gac aac gcg cgc ctg gcg gtc ctc aag cgc acg gtc gag ctg 24256 Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 4455 4460 4465 acc cac ttc gcc tac ccg gcg ctc aac ctg ccc ccc aag gtc atg 24301 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met 4470 4475 4480 agc gcc gtc atg gac cag gtg ctc atc aag cgc gcc tcg ccc ctc 24346 Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu 4485 4490 4495 tcg gag gag gag atg cag gac ccc gag agc tcg gac gag ggc aag 24391 Ser Glu Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys 4500 4505 4510 ccc gtg gtc agc gac gag cag ctg gcg cgc tgg ctg gga gcg agt 24436 Pro Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser 4515 4520 4525 agc acc ccc cag agc ctg gaa gag cgg cgc aag ctc atg atg gcc 24481 Ser Thr Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala 4530 4535 4540 gtg gtc ctg gtg acc gtg gag ctg gag tgt ctg cgc cgc ttc ttt 24526 Val Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe 4545 4550 4555 gcc gac gcg gag acc ctg cgc aag gtc gag gag aac ctg cac tac 24571 Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr 4560 4565 4570 ctc ttc agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aac 24616 Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn 4575 4580 4585 gtg gag ctg acc aac ctg gtc tcc tac atg ggc atc ctg cac gag 24661 Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu 4590 4595 4600 aac cgc ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag 24706 Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu 4605 4610 4615 gcc cgc cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc 24751 Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys 4620 4625 4630 cac acc tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag 24796 His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu 4635 4640 4645 gag cag aac ctg aaa gag ctc tgc aag ctc ctg cag aag aac ctg 24841 Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu 4650 4655 4660 aag gcc ctg tgg acc ggg ttc gac gag cgc acc acc gcc tcg gac 24886 Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp 4665 4670 4675 ctg gcc gac ctc atc ttc ccc gag cgc ctg cgg ctg acg ctg cgc 24931 Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg 4680 4685 4690 aac ggg ctg ccc gac ttt atg agc caa agc atg ttg caa aac ttt 24976 Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 4695 4700 4705 cgc tct ttc atc ctc gaa cgc tcc ggg atc ctg ccc gcc acc tgc 25021 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys 4710 4715 4720 tcc gcg ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc 25066 Ser Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys 4725 4730 4735 ccc ccg ccg ctc tgg agc cac tgc tac ttg ctg cgc ctg gcc aac 25111 Pro Pro Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn 4740 4745 4750 tac ctg gcc tac cac tcg gac gtg atc gag gac gtc agc ggc gag 25156 Tyr Leu Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu 4755 4760 4765 ggt ctg ctc gag tgc cac tgt cgc tgc aac ctc tgc acg ccg cac 25201 Gly Leu Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His 4770 4775 4780 cgc tcc ctg gcc tgc aac ccc cag ctg ctg agc gag acc cag atc 25246 Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile 4785 4790 4795 atc ggc acc ttc gag ttg caa ggc ccc ggc gag gag ggc aag ggg 25291 Ile Gly Thr Phe Glu Leu Gln Gly Pro Gly Glu Glu Gly Lys Gly 4800 4805 4810 ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg gcc tac ttg cgc 25336 Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg 4815 4820 4825 aag ttc gtg ccc gag gac tac cat ccc ttc gag atc agg ttc tac 25381 Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr 4830 4835 4840 gag gac caa tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc 25426 Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val 4845 4850 4855 atc acc cag ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa 25471 Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys 4860 4865 4870 tcc cgc caa gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ttg 25516 Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu 4875 4880 4885 gac ccc cag acc gga gag gag ctc aac ccc agc ttc ccc cag gat 25561 Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp 4890 4895 4900 gcc ccg agg aag cag caa gaa gct gaa agt gga gct gcc gcc gcc 25606 Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Ala 4905 4910 4915 gcc gga gga ttt gga gga aga ctg gga gag cag tca ggc aga gga 25651 Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 4920 4925 4930 gat gga aga ctg gga cag cac tca ggc aga gga gga cag cct gca 25696 Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 4935 4940 4945 aga cag tct gga gga gga aga cga ggt gga gga gga ggc aga gga 25741 Arg Gln Ser Gly Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly 4950 4955 4960 aga agc agc cgc cgc cag acc gtc gtc ctc ggc gga gaa agc aag 25786 Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys 4965 4970 4975 cag cac gga tac cat ctc cgc tcc ggg tcg ggg tcg cgg cgg ccg 25831 Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro 4980 4985 4990 ggc cca cag taggtgggac gagaccgggc gcttcccgaa ccccaccacc 25880 Gly Pro Gln 4995 cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa aaacgccatc 25940 gtctcctgct tgcaagcctg cgggggcaac atctccttca cccggcgcta cctgctcttc 26000 caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct ccacagcccc 26060 tactactgtt tccaagaaga ggcagaaacc cagcagcagc agaaaaccag cggcagcagc 26120 agctagaaaa tccacagcgg cggcaggtgg actgaggatc gcggcgaacg agccggcgca 26180 gacccgggag ctgaggaacc ggatctttcc caccctctat gccatcttcc agcagagtcg 26240 ggggcaggag caggaactga aagtcaagaa ccgttctctg cgctcgctca cccgcagttg 26300 tctgtatcac aagagcgaag accaacttca gcgcactctc gaggacgccg aggctctctt 26360 caacaagtac tgcgcgctca ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa 26420 ggcgggaatt acgtcaccac ctgcgccctt cgcccgacca tc atg agc aaa gag 26474 Met Ser Lys Glu att ccc acg cct tac atg tgg agc tac cag ccc cag atg ggc ctg 26519 Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly Leu 5000 5005 5010 gcc gcc ggc gcc gcc cag gac tac tcc acc cgc atg aac tgg ctc 26564 Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu 5015 5020 5025 agt gcc ggg ccc gcg atg atc tca cgg gtg aat gac atc cgc gcc 26609 Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg Ala 5030 5035 5040 cgc cga aac cag ata ctc cta gaa cag tca gcg atc acc gcc acg 26654 Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 5045 5050 5055 ccc cgc cat cac ctt aat ccg cgt aat tgg ccc gcc gcc ctg gtg 26699 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val 5060 5065 5070 tac cag gaa att ccc cag ccc acg acc gta cta ctt ccg cga gac 26744 Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp 5075 5080 5085 gcc cag gcc gaa gtc cag ctg act aac tca ggt gtc cag ctg gcc 26789 Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala 5090 5095 5100 ggc ggc gcc gcc ctg tgt cgt cac cgc ccc gct cag ggt ata aag 26834 Gly Gly Ala Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys 5105 5110 5115 cgg ctg gtg atc cga ggc aga ggc aca cag ctc aac gac gag gtg 26879 Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val 5120 5125 5130 gtg agc tct tcg ctg ggt ctg cga cct gac gga gtc ttc caa ctc 26924 Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln Leu 5135 5140 5145 gcc gga tcg ggg aga tct tcc ttc acg cct cgt cag gcc gtc ctg 26969 Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val Leu 5150 5155 5160 act ttg gag agt tcg tcc tcg cag ccc cgc tcg ggc ggc atc ggc 27014 Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly 5165 5170 5175 act ctc cag ttc gtg gag gag ttc act ccc tcg gtc tac ttc aac 27059 Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn 5180 5185 5190 ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac gag ttc atc ccg 27104 Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile Pro 5195 5200 5205 aac ttc gac gcc atc agc gag tcg gtg gac ggc tac gat tga atg 27149 Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp Met 5210 5215 5220 tcc cat ggt ggc gca gct gac cta gct cgg ctt cga cac ctg gac 27194 Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 5225 5230 5235 cac tgc cgc cgc ttc cgc tgc ttc gct cgg gat ctc gcc gag ttt 27239 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe 5240 5245 5250 gcc tac ttt gag ctg ccc gag gag cac cct cag ggc cca gcc cac 27284 Ala Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His 5255 5260 5265 gga gtg cgg atc atc gtc gaa ggg ggc ctc gac tcc cac ctg ctt 27329 Gly Val Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu 5270 5275 5280 cgg atc ttc agc cag cga ccg atc ctg gtc gag cgc gaa caa gga 27374 Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly 5285 5290 5295 cag acc cgt ctg acc ctg tac tgc atc tgc aac cac ccc ggc ctg 27419 Gln Thr Arg Leu Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu 5300 5305 5310 cat gaa agt ctt tgt tgt ctg ctg tgt act gag tat aat aaa agc 27464 His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5315 5320 5325 tgagatcagc gactactccg gactcgattg tggtgttcct gctatcaacc ggtccctgtt 27524 cttcaccggg aacgaaaccg agctccagct ccagtgtaag ccccacaaga agtacctcac 27584 ctggctgttc cagggctccc ccatcgccgt tgtcaaccac tgcgacaacg acggagtcct 27644 gctgagcggc cctgccaacc ttactttttc cacccgcaga agcaagctcc agctcttcca 27704 acccttcctc cccgggacct atcagtgcgt ctcgggaccc tgccatcaca ccttccacct 27764 gatcccgaat accacagcgc cgctccccgc tactaacaac caaactaacc tccaccaacg 27824 ccaccgtcgc gacctttcct ctgaatctaa taccactacc ggaggtgagc tccgaggtcg 27884 accaacctct gggatttact acggcccctg ggaggtggtg gggttaatag cgctaggcct 27944 agttgtgggt gggcttttgg ctctctgcta cctatacctc ccttgctgtt cgtacttagt 28004 ggtgctgtgt tgctggttta agaa atg ggg cag atc acc cta gtg agc tgc 28055 Met Gly Gln Ile Thr Leu Val Ser Cys 5330 5335 ggt gtg ctg gtg gcg gtg ctt tcg att gtg gga ctg ggc ggc gcg 28100 Gly Val Leu Val Ala Val Leu Ser Ile Val Gly Leu Gly Gly Ala 5340 5345 5350 gct gta gtg aag gag gag aag gcc gat ccc tgc ttg cat ttc aat 28145 Ala Val Val Lys Glu Glu Lys Ala Asp Pro Cys Leu His Phe Asn 5355 5360 5365 ccc gac aaa tgc cag ctg agt ttt cag ccc gat ggc aat cgg tgc 28190 Pro Asp Lys Cys Gln Leu Ser Phe Gln Pro Asp Gly Asn Arg Cys 5370 5375 5380 gcg gtg ctg atc aag tgc gga tgg gaa tgc gag aac gtg aga atc 28235 Ala Val Leu Ile Lys Cys Gly Trp Glu Cys Glu Asn Val Arg Ile 5385 5390 5395 gag tac aat aac aag act cgg aac aat act ctc gcg tcc gtg tgg 28280 Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu Ala Ser Val Trp 5400 5405 5410 cag ccc ggg gac ccc gag tgg tac acc gtc tct gtc ccc ggt gct 28325 Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val Pro Gly Ala 5415 5420 5425 gac ggc tcc ccg cgc acc gtg aat aat act ttc att ttt gcg cac 28370 Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe Ala His 5430 5435 5440 atg tgc aac acg gtc atg tgg atg agc aag cag tac gat atg tgg 28415 Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met Trp 5445 5450 5455 ccc ccc acg aag gag aac atc gtg gtc ttc tcc atc gct tac agc 28460 Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 5460 5465 5470 ctg tgc acg gcg cta atc acc gct atc gtg tgc ctg agc att cac 28505 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His 5475 5480 5485 atg ctc atc gct att cgc ccc aga aat aat gcc gag aaa gag aaa 28550 Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys 5490 5495 5500 cag cca taacacgttt tttcacacac cttgttttta cagaca atg cgt ctg tta 28604 Gln Pro Met Arg Leu Leu 5505 aat ttt tta aac att gtg ctc agt att gct tat gcc tct ggt tat 28649 Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala Ser Gly Tyr 5510 5515 5520 gca aac ata cag aaa acc ctt tat gta gga tct gat ggt aca cta 28694 Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Gly Thr Leu 5525 5530 5535 gag ggt acc caa tca caa gcc aag gtt gca tgg tat ttt tat aga 28739 Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr Phe Tyr Arg 5540 5545 5550 acc aac act gat cca gtt aaa ctt tgt aag ggt gaa ttg ccg cgt 28784 Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu Leu Pro Arg 5555 5560 5565 aca cat aaa act cca ctt aca ttt agt tgc agc aat aat aat ctt 28829 Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn Asn Asn Leu 5570 5575 5580 aca ctt ttt tca att aca aaa caa tat act ggt act tat tac agt 28874 Thr Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr Tyr Tyr Ser 5585 5590 5595 aca aac ttt cat aca gga caa gat aaa tat tat act gtt aag gta 28919 Thr Asn Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val 5600 5605 5610 gaa aat cct acc act cct aga act acc acc acc acc acc act act 28964 Glu Asn Pro Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr Thr Thr 5615 5620 5625 gca aag ccc act gtg aaa act aca act agg acc acc aca act aca 29009 Ala Lys Pro Thr Val Lys Thr Thr Thr Arg Thr Thr Thr Thr Thr 5630 5635 5640 gaa acc acc acc agc aca aca ctt gct gca act aca cac aca cac 29054 Glu Thr Thr Thr Ser Thr Thr Leu Ala Ala Thr Thr His Thr His 5645 5650 5655 act aag cta acc tta cag acc act aat gat ttg atc gcc ctg ctg 29099 Thr Lys Leu Thr Leu Gln Thr Thr Asn Asp Leu Ile Ala Leu Leu 5660 5665 5670 caa aag ggg gat aac agc acc act tcc aat gag gag ata ccc aaa 29144 Gln Lys Gly Asp Asn Ser Thr Thr Ser Asn Glu Glu Ile Pro Lys 5675 5680 5685 tcc atg att ggc att att gtt gct gta gtg gtg tgc atg ttg atc 29189 Ser Met Ile Gly Ile Ile Val Ala Val Val Val Cys Met Leu Ile 5690 5695 5700 atc gcc ttg tgc atg gtg tac tat gcc ttc tgc tac aga aag cac 29234 Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His 5705 5710 5715 aga ctg aac gac aag ctg gaa cac tta cta agt gtt gaa ttt 29276 Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 5720 5725 5730 taatttttta gaacc atg aag atc cta ggc ctt ttt agt ttt tct atc 29324 Met Lys Ile Leu Gly Leu Phe Ser Phe Ser Ile 5735 5740 att acc tct gct ctt tgt gaa tca gtg gat aga gat gtt act att 29369 Ile Thr Ser Ala Leu Cys Glu Ser Val Asp Arg Asp Val Thr Ile 5745 5750 5755 acc act ggt tct aat tat aca ctg aaa ggg cca ccc tca ggt atg 29414 Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly Pro Pro Ser Gly Met 5760 5765 5770 ctt tcg tgg tat tgc tat ttt gga act gac act gat caa act gaa 29459 Leu Ser Trp Tyr Cys Tyr Phe Gly Thr Asp Thr Asp Gln Thr Glu 5775 5780 5785 tta tgc aat ttt caa aaa ggc aaa acc tca aac tct aaa atc tct 29504 Leu Cys Asn Phe Gln Lys Gly Lys Thr Ser Asn Ser Lys Ile Ser 5790 5795 5800 aat tat caa tgc aat ggc act gat ctg ata cta ctc aat gtc acg 29549 Asn Tyr Gln Cys Asn Gly Thr Asp Leu Ile Leu Leu Asn Val Thr 5805 5810 5815 aaa gca tat ggt ggc agt tat tat tgc cct gga caa aac act gaa 29594 Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro Gly Gln Asn Thr Glu 5820 5825 5830 gaa atg att ttt tac aaa gtg gaa gtg gtt gat ccc act aca cca 29639 Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp Pro Thr Thr Pro 5835 5840 5845 ccc acc acc aca act att cat acc aca cac aca gaa caa aca cca 29684 Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu Gln Thr Pro 5850 5855 5860 gag gca aca gaa gca gag ttg gcc ttc cag gtt cac gga gat tcc 29729 Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly Asp Ser 5865 5870 5875 ttt gct gtc aat acc cct aca ccc gat cag cgg tgt ccg ggg ccg 29774 Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly Pro 5880 5885 5890 cta gtc agc ggc att gtc ggt gtg ctt tcg gga tta gca gtc ata 29819 Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 5895 5900 5905 atc atc tgc atg ttc att ttt gct tgc tgc tat aga agg ctt tac 29864 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr 5910 5915 5920 cga caa aaa tca gac cca ctg ctg aac ctc tat gtt taattttttc 29910 Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 5925 5930 5935 cagagcc atg aag gca gtt agc gct cta gtt ttt tgt tct ttg att ggc 29959 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly 5940 5945 att gtt ttt aat agt aaa att acc aaa gtt agc ttt att aaa cat 30004 Ile Val Phe Asn Ser Lys Ile Thr Lys Val Ser Phe Ile Lys His 5950 5955 5960 gtt aat gta act gaa gga gat aac atc aca cta gca ggt gta gaa 30049 Val Asn Val Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu 5965 5970 5975 ggt gct caa aac acc acc tgg aca aaa tac cat cta gga tgg aga 30094 Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg 5980 5985 5990 gat att tgc acc tgg aat gta act tat tat tgc ata gga att aat 30139 Asp Ile Cys Thr Trp Asn Val Thr Tyr Tyr Cys Ile Gly Ile Asn 5995 6000 6005 ctt acc att gtt aac gct aac caa tct cag aat ggg tta att aaa 30184 Leu Thr Ile Val Asn Ala Asn Gln Ser Gln Asn Gly Leu Ile Lys 6010 6015 6020 gga cag agt gtt agt gtg acc agt gat ggg tac tat acc cag cat 30229 Gly Gln Ser Val Ser Val Thr Ser Asp Gly Tyr Tyr Thr Gln His 6025 6030 6035 agt ttt aac tac aac att act gtc ata cca ctg cct acg cct agc 30274 Ser Phe Asn Tyr Asn Ile Thr Val Ile Pro Leu Pro Thr Pro Ser 6040 6045 6050 cca cct agc act acc aca cag aca acc aca tac agt aca tca aat 30319 Pro Pro Ser Thr Thr Thr Gln Thr Thr Thr Tyr Ser Thr Ser Asn 6055 6060 6065 cag cct acc acc act aca gca gca gag gtt gcc agc tcg tct ggg 30364 Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala Ser Ser Ser Gly 6070 6075 6080 gtc cga gtg gca ttt ttg atg ttg gcc cca tct agc agt ccc act 30409 Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser Ser Ser Pro Thr 6085 6090 6095 gct agt acc aat gag cag act act gaa ttt ttg tcc act gtc gag 30454 Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser Thr Val Glu 6100 6105 6110 agc cac acc aca gct acc tcc agt gcc ttc tct agc acc gcc aat 30499 Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn 6115 6120 6125 ctc tcc tcg ctt tcc tct aca cca atc agc ccc gct act act cct 30544 Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr Pro 6130 6135 6140 agc ccc gct cct ctt ccc act ccc ctg aag caa aca gac ggc ggc 30589 Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 6145 6150 6155 atg caa tgg cag atc acc ctg ctc att gtg atc ggg ttg gtc atc 30634 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile 6160 6165 6170 ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc cgc att ccc aac 30679 Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn 6175 6180 6185 gcg cac cgc aag ccg gcc tac aag ccc atc gtt atc ggg cag ccg 30724 Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro 6190 6195 6200 gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt ctc ttc tct 30769 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser 6205 6210 6215 ttt aca gta tgg tgattgaact atg att cct aga caa ttc ttg atc act 30818 Phe Thr Val Trp Met Ile Pro Arg Gln Phe Leu Ile Thr 6220 6225 6230 att ctt atc tgc ctc ctc caa gtc tgt gcc acc ctc gct ctg gtg 30863 Ile Leu Ile Cys Leu Leu Gln Val Cys Ala Thr Leu Ala Leu Val 6235 6240 6245 gcc aac gcc agt cca gac tgt att ggg ccc ttc gcc tcc tac gtg 30908 Ala Asn Ala Ser Pro Asp Cys Ile Gly Pro Phe Ala Ser Tyr Val 6250 6255 6260 ctc ttt gcc ttc atc acc tgc atc tgc tgc tgt agc ata gtc tgc 30953 Leu Phe Ala Phe Ile Thr Cys Ile Cys Cys Cys Ser Ile Val Cys 6265 6270 6275 ctg ctt atc acc ttc ttc cag ttc att gac tgg atc ttt gtg cgc 30998 Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp Trp Ile Phe Val Arg 6280 6285 6290 atc gcc tac ctg cgc cac cac ccc cag tac cgc gac cag cga gtg 31043 Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg Asp Gln Arg Val 6295 6300 6305 gcg cag ctg ctc agg ctc ctc tgataagc atg cgg gct ctg cta ctt 31090 Ala Gln Leu Leu Arg Leu Leu Met Arg Ala Leu Leu Leu 6310 6315 6320 ctc gcg ctt ctg ctg tta gtg ctc ccc cgt ccc gtt gac ccc cgg 31135 Leu Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val Asp Pro Arg 6325 6330 6335 ccc ccc act cag tcc ccc gag gag gtc cgc aaa tgc aaa ttc caa 31180 Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys Lys Phe Gln 6340 6345 6350 gaa ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa tca gac atg 31225 Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys Ser Asp Met 6355 6360 6365 cat ccc agc tgg atc atg atc att ggg atc gtg aac att ctg gcc 31270 His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile Leu Ala 6370 6375 6380 tgc acc ctc atc tcc ttt gtg att tac ccc tgc ttt gac ttt ggt 31315 Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe Gly 6385 6390 6395 tgg aac tcg cca gag gcg ctc tat ctc ccg cct gaa cct gac aca 31360 Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 6400 6405 6410 cca cca cag caa cct cag gca cac gca cta cca cca cca cca cag 31405 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln 6415 6420 6425 cct agg cca caa tac atg ccc ata tta gac tat gag gcc gag cca 31450 Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro 6430 6435 6440 cag cga ccc atg ctc ccc gct att agt tac ttc aat cta acc ggc 31495 Gln Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly 6445 6450 6455 gga gat gac tgacccactg gccaacaaca acgtcaacga ccttctcctg 31544 Gly Asp Asp gacatggacg gccgcgcctc ggagcagcga ctcgcccaac ttcgcattcg ccagcagcag 31604 gagagagccg tcaaggagct gcaggacggc atagccatcc accagtgcaa gaaaggcatc 31664 ttctgcctgg tgaaacaggc caagatctcc tacgaggtca cccagaccga ccatcgcctc 31724 tcctacgagc tcctgcagca gcgccagaag ttcacctgcc tggtcggagt caaccccatc 31784 gtcatcaccc agcagtcggg cgataccaag gggtgcatcc actgctcctg cgactccccc 31844 gactgcgtcc acactctgat caagaccctc tgcggcctcc gcgacctcct ccccatgaac 31904 taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa aaaaaataat 31964 catttgattt gaaataaaga tacaatcata ttgatgattt gagtttaata aaaataaaga 32024 atcacttact tgaaatctga taccaggtct ctgtccatgt tttctgccaa caccacttca 32084 ctcccctctt cccagctctg gtactgcagg ccccggcggg ctgcaaactt cctccacacc 32144 ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc tatcag atg 32203 Met tcc aaa aag cgc gtc cgg gtg gat gat gac ttc gac ccc gtc tac 32248 Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 6460 6465 6470 ccc tac gat gca gac aac gca ccg acc gtg ccc ttc atc aac ccc 32293 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro 6475 6480 6485 ccc ttc gtc tct tca gat gga ttc caa gag aag ccc ctg ggg gtg 32338 Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val 6490 6495 6500 ctg tcc ctg cgt ctg gcc gat ccc gtc acc acc aag aac ggg gaa 32383 Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu 6505 6510 6515 atc acc ctc aag ctg gga gat ggg gtg gac ctc gac gac tcg gga 32428 Ile Thr Leu Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly 6520 6525 6530 aaa ctc atc tcc aac acg gcc acc aag gcc gcc gcc cct ctc agt 32473 Lys Leu Ile Ser Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser 6535 6540 6545 ttt tcc aac aac acc att tcc ctt aac atg gat acc cct ctt tac 32518 Phe Ser Asn Asn Thr Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr 6550 6555 6560 aac aac aat gga aag cta ggt atg aag gta acc gca cca tta aag 32563 Asn Asn Asn Gly Lys Leu Gly Met Lys Val Thr Ala Pro Leu Lys 6565 6570 6575 ata tta gac aca gat cta cta aaa aca ctt gtt gtt gct tat ggg 32608 Ile Leu Asp Thr Asp Leu Leu Lys Thr Leu Val Val Ala Tyr Gly 6580 6585 6590 cag gga tta gga aca aac acc aat ggt gct ctt gtt gcc caa cta 32653 Gln Gly Leu Gly Thr Asn Thr Asn Gly Ala Leu Val Ala Gln Leu 6595 6600 6605 gca tac cca ctt gtt ttt aat acc gct agc aaa att gcc ctt aat 32698 Ala Tyr Pro Leu Val Phe Asn Thr Ala Ser Lys Ile Ala Leu Asn 6610 6615 6620 tta ggc aat gga cca tta aaa gtg gat gca aat aga ctg aac att 32743 Leu Gly Asn Gly Pro Leu Lys Val Asp Ala Asn Arg Leu Asn Ile 6625 6630 6635 aat tgc aaa aga ggt atc tat gtc act acc aca aaa gat gca ctg 32788 Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr Lys Asp Ala Leu 6640 6645 6650 gag att aat atc agt tgg gca aat gct atg aca ttt ata gga aat 32833 Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe Ile Gly Asn 6655 6660 6665 gcc att ggt gtc aat att gac aca aaa aaa ggc cta cag ttc ggc 32878 Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln Phe Gly 6670 6675 6680 act tca agc act gaa aca gat gtt aaa aat gct ttt cca ctc caa 32923 Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu Gln 6685 6690 6695 gta aaa ctt gga gct ggt ctt aca ttt gac agc aca ggt gcc att 32968 Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 6700 6705 6710 gtt gct tgg aac aaa gaa gat gac aaa ctt aca ctg tgg acc aca 33013 Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr 6715 6720 6725 gcc gat cca tct cca aac tgt cac ata tat tct gca aag gat gct 33058 Ala Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala 6730 6735 6740 aag ctt aca ctc tgc ttg aca aag tgt ggt agt cag ata ctg ggc 33103 Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly 6745 6750 6755 act gtt tct ctc ata gct gtt gat act ggt agc tta aat cca ata 33148 Thr Val Ser Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile 6760 6765 6770 aca gga aaa gta acc act gct ctt gtt tca ctt aaa ttc gat gcc 33193 Thr Gly Lys Val Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala 6775 6780 6785 aat gga gtt ttg caa gcc agt tca aca cta gat aaa gaa tat tgg 33238 Asn Gly Val Leu Gln Ala Ser Ser Thr Leu Asp Lys Glu Tyr Trp 6790 6795 6800 aat ttc aga aaa gga gat gtg aca cct gct gac ccc tac act aat 33283 Asn Phe Arg Lys Gly Asp Val Thr Pro Ala Asp Pro Tyr Thr Asn 6805 6810 6815 gct ata ggc ttt atg ccc aac ctt aat gca tac cca aaa aac aca 33328 Ala Ile Gly Phe Met Pro Asn Leu Asn Ala Tyr Pro Lys Asn Thr 6820 6825 6830 aac gca gct gca aaa agt cac att gtt gga aaa gta tac cta cat 33373 Asn Ala Ala Ala Lys Ser His Ile Val Gly Lys Val Tyr Leu His 6835 6840 6845 ggg gat gta agc aag cca cta gac ttg ata att aca ttt aat gaa 33418 Gly Asp Val Ser Lys Pro Leu Asp Leu Ile Ile Thr Phe Asn Glu 6850 6855 6860 acc agt gat gaa tcc tgt act tat tgc att aac ttt cag tgg cag 33463 Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile Asn Phe Gln Trp Gln 6865 6870 6875 tgg gga act gac caa tat aaa gat gaa aca ctt gca gtc agt tca 33508 Trp Gly Thr Asp Gln Tyr Lys Asp Glu Thr Leu Ala Val Ser Ser 6880 6885 6890 ttc acc ttc tca tac att gct aaa gaa taacatccac cctgcatgcc 33555 Phe Thr Phe Ser Tyr Ile Ala Lys Glu 6895 6900 aacccatttc cctctatcta tacatggaaa actctgaagc agaaaaaata aagttcaagt 33615 gttttattga ttcaacagtt tttacagaat tcgagtagtt attttccctc caccctccca 33675 actcatggaa tacaccatcc tctccccacg cacagcctta aacatctgaa tgccattggt 33735 aatggacatg gttttggcct ccacattcca cacagtttca gagcgagcca gtctcgggtc 33795 ggtcagggag atgaaaccct ccgggcactc ctgcatctgc acctcacagt tcaacagctg 33855 agggctgtcc tcggtggtcg ggatcacggt tatctggaag aagagcgatg agaatcataa 33915 tccgcgaacg ggatcgggcg gttgtggcgc atcaggcccc gcagcagtcg ctgtctgcgc 33975 cgctccgtca agctgctgct caaggggtcc gggtccaggg actccctgcg catgatgccg 34035 atggccctga gcatcagtcg cctggtgcgg cgggcgcagc agcggatgcg gatctcactc 34095 aggtcggagc agtacgtgca gcacagcacc accaagttgt tcaacagtcc atagttcaac 34155 acgctccagc caaaactcat ctgtggaact atgctgccca cgtgtccatc gtaccagatc 34215 ctgatgtaaa tcaggtggcg ccccctccag aacacactgc ccatgtacat gatctccttg 34275 ggcatatgca ggttcaccac ctcccggtac cacatcaccc gctggttgaa catgcagccc 34335 tggataattc tgcggaacca gatggccagc accgccccgc ccgccatgca gcgcagggac 34395 cccgggtcct gacagtggca gtggaggacc caccgctcgc ggccgtggat caactgggag 34455 ctgaacaggt ctatgttggc acagcacagg cacacgctca tgcatgtctt cagcactctc 34515 agttcctcgg gggtcaggac catgtcccag ggcacgggga actcttgcag gacagtgaac 34575 ccggcagaac agggcagccc tcgcacacaa cttacattgt gcatggacag ggtatcgcaa 34635 tcaggcagca ccggatgatc ctccaccaga gaagcgcggg tctcggtctc ctcacaacga 34695 ggtaaggggg ccggcggttg gtacggatga tggcgggatg acgctaatcg tgttctggat 34755 cgtgtcatga tggagcttct tcctgacatc ttcgtatttc atgtagcaga acctggtccg 34815 ggcactgcac accgctcgcc ggcgacggtc tcggcgcttc gagcgctcgg tgttgaagtt 34875 gtaaaacagc cactccctca gagcgtgcag tatctcttga gcctcttggg tgatgaaaat 34935 cccatccgcc ctgatggctc tgatcacatc gaccacggtg gaatgggcca gacccagcca 34995 gatgatgcaa ttttgttggg tttcggtgac ggcgggggag ggaagaacag gaagaaccat 35055 gattaacttt attccaaacg gtctcggagc acttcaaaat gcaggtcgcg gagatggcac 35115 ctctcgcccc cactgtgttg atggaaaata acagccaggt caaaggtgac acggttctcg 35175 agatgttcca cggtggcttc cagcaaagcc tccacgcgca catccagaaa caagaggaca 35235 gcgaaagcgg gagcgttctc taattcctca atcatcatat tacactcctg caccatcccc 35295 agataatttt catttttcca gccttgaatg atttgaacta gttcctgagg taaatccaag 35355 ccagccatga taaaaagctc gcgcagagcg ccctccaccg gcattcttaa gcacaccctc 35415 ataattccaa gagattctgc tcctggttca cctgcagcag attaacaagg ggaatatcaa 35475 aatctctgcc gcgatctcta agctcctccc tcagcaataa ctgcaagtac tctttcatat 35535 cttctccgaa atttttagcc atagggccgc caggaatgag agcagggcaa gccacattac 35595 agataaagcg aagtcctccc cagtgagcat tgccaaatgt aagattgaaa taagcatgct 35655 ggctagaccc ggtgatatct tccagataac tggacagaaa atcaggcaag caatttttaa 35715 gaaaatcaac aaaagaaaag tcgtccaggt gcaagtttag agcctcagga acaacgatgg 35775 aataagtgca aggagtgcgt tccagcatgg ttagtgtttt tttggtgatc tgtagaacaa 35835 aaaataaaca tgcaatatta aaccatgcta gcctggcgaa caggtgggta aatcactctt 35895 tccagcacca ggcaggctac ggggtctccg gcgcgaccct cgtagaagct gtcgccatga 35955 ttgaaaagca tcaccgaaag actttcccgg tggccggcat ggatgattcg cgaagacgcg 36015 tacactccgg gaacattggc atccgtgagt gaaaaaaatc gccccaagaa gccccgaggc 36075 actacaatgc tcaaccttaa ttccagcaga gcgaccccat gcggatgaag cacaaaattg 36135 gtaggtgcgt aaaaaatgta attactcccc tcctgcacag gcagcaaagc ccccgctccc 36195 tccagaaaca catacaaagc ctcagcgtcc atagcttacc gagcacggca ggcgcaagat 36255 tcagagaaaa ggctgagctc taacctgact gcccgctcct gagctcaata tatagcccta 36315 acctacactg acgtaaaggc caaagtctaa aaatacccgc caaaatgaca cacacgccca 36375 gcacacgccc agaaaccggt gacacactca aaaaaatacg tgcgcttcct caaacgccca 36435 aaccggcgtc atttccgggt tcccacgcta cgtcaccgct cagcgacttt caaatttcgt 36495 cgaccgttaa acacgtcact cgccccgccc ctaacggtcg ccctcctctc ggccaatcac 36555 agccccgcat ccccaaattc aaacgcctca tttgcatatt aacgcgcaca aaaagtttga 36615 ggtatattat ttgatgatg 36634 <210> 34 <211> 503 <212> PRT <213> Simian adenovirus 37 <400> 34 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser 65 70 75 80 Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu 85 90 95 Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile 100 105 110 Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val 115 120 125 Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val 130 135 140 Gln Ser Gln Gly Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser 145 150 155 160 Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu 165 170 175 Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys 180 185 190 Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser 195 200 205 Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe 210 215 220 Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly 225 230 235 240 Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val 245 250 255 Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe 260 265 270 Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg 275 280 285 Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys 290 295 300 Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly 305 310 315 320 Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu 325 330 335 Thr Gly Cys Phe Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn 340 345 350 Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys 355 360 365 Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His 370 375 380 Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys 385 390 395 400 Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys 405 410 415 Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg 420 425 430 Val Ser Leu Ala Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile 435 440 445 Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly 450 455 460 Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp 465 470 475 480 Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly 485 490 495 Ser Ser Gly Glu Glu Ser Asp 500 <210> 35 <211> 157 <212> PRT <213> Simian adenovirus 37 <400> 35 Met Arg Gly Arg Met Thr Lys Ile Cys Val Phe Leu Cys Ser Ser Met 1 5 10 15 Ser Gly Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr 20 25 30 Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser 35 40 45 Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr 50 55 60 Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala 65 70 75 80 Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly 85 90 95 Tyr Tyr Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala 100 105 110 Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala 115 120 125 Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln 130 135 140 Ala Glu Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 145 150 155 <210> 36 <211> 392 <212> PRT <213> Simian adenovirus 37 <400> 36 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Ser 35 40 45 Tyr Asp His Gln Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu 50 55 60 Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp 65 70 75 80 Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser 85 90 95 Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg 100 105 110 Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp 115 120 125 Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val 130 135 140 Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu 145 150 155 160 Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala 165 170 175 Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu 180 185 190 Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe 195 200 205 Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu 210 215 220 Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn 225 230 235 240 Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu 245 250 255 Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr 260 265 270 Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val 275 280 285 Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu 290 295 300 Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val 305 310 315 320 Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser 325 330 335 Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe 340 345 350 Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu 355 360 365 Ala Ala Gly Gly Ser Pro Tyr Val Glu Glu Val Asp Asp Glu Val Asp 370 375 380 Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 37 <211> 593 <212> PRT <213> Simian adenovirus 37 <400> 37 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala 530 535 540 Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp 545 550 555 560 Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser 565 570 575 Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met 580 585 590 Met <210> 38 <211> 542 <212> PRT <213> Simian adenovirus 37 <400> 38 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Lys Val Asp Asp Thr Tyr Asp 145 150 155 160 Gly Ser Gln Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro 165 170 175 Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala 180 185 190 Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu 195 200 205 Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp 210 215 220 Asp Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala 225 230 235 240 Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr 245 250 255 Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe 260 265 270 Gln Glu Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile 275 280 285 Pro Ala Leu Leu Asp Val Glu Ala Tyr Glu Asp Ser Lys Lys Lys Ala 290 295 300 Glu Ala Glu Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Asn Ala Asp 305 310 315 320 Ala Asn Val Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala 325 330 335 Ala Ala Leu Ala Val Ala Asp Asp Ser Glu Ser Lys Ile Val Ile Gln 340 345 350 Pro Val Lys Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu Pro Asp 355 360 365 Glu Val Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly 370 375 380 Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp 385 390 395 400 Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 405 410 415 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro 420 425 430 Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn 435 440 445 Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr 450 455 460 His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro 465 470 475 480 Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 485 490 495 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val 500 505 510 Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala 515 520 525 Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 540 <210> 39 <211> 193 <212> PRT <213> Simian adenovirus 37 <400> 39 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 40 <211> 346 <212> PRT <213> Simian adenovirus 37 <400> 40 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Val Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp 35 40 45 Met Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Arg Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu 115 120 125 Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu 130 135 140 Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg 145 150 155 160 Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu 165 170 175 Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys 180 185 190 Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln 195 200 205 Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr 210 215 220 Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr 225 230 235 240 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr 245 250 255 Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn 260 265 270 Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr 275 280 285 Arg Phe Tyr Arg Gly Tyr Ser Ser Arg Arg Lys Thr Thr Thr Arg Arg 290 295 300 Arg Arg Arg Arg Thr Arg Arg Ser Thr Thr Ala Thr Ser Ala Ala Ala 305 310 315 320 Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr Leu Pro 325 330 335 Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 41 <211> 77 <212> PRT <213> Simian adenovirus 37 <400> 41 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 42 <211> 241 <212> PRT <213> Simian adenovirus 37 <400> 42 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Val Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Ser Ser Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu Pro Pro 180 185 190 Pro Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 195 200 205 Ser Arg Ala Leu Arg Gly Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu 210 215 220 Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys 225 230 235 240 Tyr <210> 43 <211> 942 <212> PRT <213> Simian adenovirus 37 <400> 43 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Gln Ala Lys Thr Gly Asn Gly Gly 130 135 140 Thr Met Glu Thr His Thr Tyr Gly Val Ala Pro Met Gly Gly Glu Asn 145 150 155 160 Ile Thr Lys Asp Gly Leu Gln Ile Gly Thr Asp Val Thr Ala Asn Gln 165 170 175 Asn Lys Pro Ile Tyr Ala Asp Lys Thr Phe Gln Pro Glu Pro Gln Val 180 185 190 Gly Glu Glu Asn Trp Gln Glu Thr Glu Asn Phe Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Asn Met Lys Pro Cys Tyr Gly Ser Tyr Ala Arg 210 215 220 Pro Thr Asn Glu Lys Gly Gly Gln Ala Lys Leu Lys Val Gly Asp Asp 225 230 235 240 Gly Val Pro Thr Lys Glu Phe Asp Ile Asp Leu Ala Phe Phe Asp Thr 245 250 255 Pro Gly Gly Thr Val Asn Gly Gln Asp Glu Tyr Lys Ala Asp Ile Val 260 265 270 Met Tyr Thr Glu Asn Thr Tyr Leu Glu Thr Pro Asp Thr His Val Val 275 280 285 Tyr Lys Pro Gly Lys Asp Asp Ala Ser Ser Glu Ile Asn Leu Val Gln 290 295 300 Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 305 310 315 320 Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala 325 330 335 Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn 340 345 350 Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr 355 360 365 Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp 370 375 380 Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr 385 390 395 400 Cys Phe Pro Leu Asp Gly Ser Gly Thr Asn Ala Ala Tyr Gln Gly Val 405 410 415 Lys Val Lys Asn Gly Gln Asp Gly Asp Val Glu Ser Glu Trp Glu Lys 420 425 430 Asp Asp Thr Val Ala Ala Gln Asn Gln Leu Cys Lys Gly Asn Ile Phe 435 440 445 Ala Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr 450 455 460 Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Thr 465 470 475 480 Asn Val Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly 485 490 495 Arg Val Thr Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala 500 505 510 Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His 515 520 525 Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg 530 535 540 Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys 545 550 555 560 Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg 565 570 575 Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg 580 585 590 Thr Asp Gly Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr 595 600 605 Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu 610 615 620 Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala 625 630 635 640 Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser 645 650 655 Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg 660 665 670 Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr 675 680 685 Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu 690 695 700 Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser 705 710 715 720 Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys 725 730 735 Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr 740 745 750 Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr 755 760 765 Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe 770 775 780 Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn 785 790 795 800 Tyr Lys Asp Tyr Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser 805 810 815 Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr 820 825 830 Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser 835 840 845 Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro 850 855 860 Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln 865 870 875 880 Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu 885 890 895 Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val 900 905 910 Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala 915 920 925 Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 940 <210> 44 <211> 209 <212> PRT <213> Simian adenovirus 37 <400> 44 Met Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp 195 200 205 Met <210> 45 <211> 800 <212> PRT <213> Simian adenovirus 37 <400> 45 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Thr Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro 20 25 30 Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met 35 40 45 Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 50 55 60 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 65 70 75 80 Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Asn Gln Ala Gly Leu 85 90 95 Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 100 105 110 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 115 120 125 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn 130 135 140 Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys 145 150 155 160 Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 165 170 175 Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 180 185 190 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly 195 200 205 Pro Gly Ala Arg Leu Pro Asp Ile Thr Ser Leu Glu Glu Val Pro Lys 210 215 220 Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 225 230 235 240 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 290 295 300 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Gly Glu Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly 610 615 620 Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His 625 630 635 640 Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala 645 650 655 Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu 660 665 670 Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His 675 680 685 Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe 690 695 700 Pro Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala 705 710 715 720 Ala Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg 725 730 735 Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 740 745 750 Arg Gln Ser Gly Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg 755 760 765 Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His 770 775 780 Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 800 <210> 46 <211> 227 <212> PRT <213> Simian adenovirus 37 <400> 46 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 47 <211> 106 <212> PRT <213> Simian adenovirus 37 <400> 47 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 48 <211> 176 <212> PRT <213> Simian adenovirus 37 <400> 48 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 49 <211> 228 <212> PRT <213> Simian adenovirus 37 <400> 49 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala 1 5 10 15 Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Gly 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr Phe Tyr 35 40 45 Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu Leu Pro Arg 50 55 60 Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn Asn Asn Leu Thr 65 70 75 80 Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr Thr Thr Ala Lys Pro Thr 115 120 125 Val Lys Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser 130 135 140 Thr Thr Leu Ala Ala Thr Thr His Thr His Thr Lys Leu Thr Leu Gln 145 150 155 160 Thr Thr Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr 165 170 175 Thr Ser Asn Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala 180 185 190 Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala 195 200 205 Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu 210 215 220 Ser Val Glu Phe 225 <210> 50 <211> 203 <212> PRT <213> Simian adenovirus 37 <400> 50 Met Lys Ile Leu Gly Leu Phe Ser Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Arg Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys 50 55 60 Thr Ser Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu 115 120 125 Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly 130 135 140 Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 51 <211> 288 <212> PRT <213> Simian adenovirus 37 <400> 51 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Asn Ser Lys Ile Thr Lys Val Ser Phe Ile Lys His Val Asn Val 20 25 30 Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu Gly Ala Gln Asn 35 40 45 Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg Asp Ile Cys Thr Trp 50 55 60 Asn Val Thr Tyr Tyr Cys Ile Gly Ile Asn Leu Thr Ile Val Asn Ala 65 70 75 80 Asn Gln Ser Gln Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr 85 90 95 Ser Asp Gly Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val 100 105 110 Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr 115 120 125 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 130 135 140 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 145 150 155 160 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 165 170 175 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr 180 185 190 Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 195 200 205 Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 210 215 220 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu 225 230 235 240 Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His 245 250 255 Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro Glu Pro Leu 260 265 270 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 52 <211> 91 <212> PRT <213> Simian adenovirus 37 <400> 52 Met Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 50 55 60 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Arg Val Ala Gln Leu Leu Arg Leu Leu 85 90 <210> 53 <211> 144 <212> PRT <213> Simian adenovirus 37 <400> 53 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro 100 105 110 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 115 120 125 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 54 <211> 445 <212> PRT <213> Simian adenovirus 37 <400> 54 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Asn 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Tyr Pro Leu Val Phe Asn Thr Ala 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln 210 215 220 Phe Gly Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu 225 230 235 240 Gln Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Lys Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ala Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp 340 345 350 Val Thr Pro Ala Asp Pro Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Asn Ala Tyr Pro Lys Asn Thr Asn Ala Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Val Ser Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Thr Asp Gln Tyr Lys Asp Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 55 <211> 580 <212> DNA <213> Simian adenovirus 37 <220> <221> CDS <222> (2)..(574) <223> label=Elb\19K <400> 55 t atg gag atc tgg aca gtc ttg gaa gac ttt cac cag act aga cag ctg 49 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 cta gag aac tca tcg gag gga gtc tct tac ctg tgg aga ttc tgc ttc 97 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 gct ggg cct cta gct aag cta gtc tat agg gcc aag cag gat tat agg 145 Ala Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg 35 40 45 gaa caa ttt gag gat att ttg aga gag tgt cct ggt att ttt gac tct 193 Glu Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 ctc aac ttg ggc cat cag tct cac ttt aac cag agt att ctg aga gcc 241 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 ctt gac ttt tct act cct ggc aga act acc gcc gcg gta gcc ttt ttt 289 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 gcc ttt atc ctt gac aaa tgg agt caa gaa acc cat ttc agc agg gat 337 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 tac cgt ctg gac tgc tta gca gta gct ttg tgg aga aca tgg agg tgc 385 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 cag cgc ctg aat gca atc tcc ggc tac ttg cca gta cag ccg gta gac 433 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 acg ctg agg atc ctg agt ctc cag tca ccc cag gaa cac caa cgc cgc 481 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 cag cag ccg cag cag gag cag cag caa gag gag gag gac cga gaa gag 529 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu 165 170 175 aac ccg aga gcc ggt ctg gac cct ccg gtg gcg gag gag gag gag 574 Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 tagctg 580 <210> 56 <211> 191 <212> PRT <213> Simian adenovirus 37 <400> 56 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Ala Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg 35 40 45 Glu Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu 165 170 175 Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 57 <211> 6360 <212> DNA <213> Simian adenovirus 37 <220> <221> CDS <222> (10)..(573) <223> label=22K <220> <221> CDS <222> (1871)..(2494) <223> label=E3\CR1\alpha <220> <221> CDS <222> (5950)..(6354) <223> label=E3\14.7K <400> 57 tcccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 51 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag 99 Pro Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 147 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa 195 Asp Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu 50 55 60 gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca agc agc acg 243 Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 291 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 agg tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc ggt 339 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly 95 100 105 110 aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc 387 Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala 115 120 125 atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg 435 Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg 130 135 140 cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg 483 Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu 145 150 155 cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa gag 531 His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu 160 165 170 gca gaa acc cag cag cag cag aaa acc agc ggc agc agc agc 573 Ala Glu Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser 175 180 185 tagaaaatcc acagcggcgg caggtggact gaggatcgcg gcgaacgagc cggcgcagac 633 ccgggagctg aggaaccgga tctttcccac cctctatgcc atcttccagc agagtcgggg 693 gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc tcgctcaccc gcagttgtct 753 gtatcacaag agcgaagacc aacttcagcg cactctcgag gacgccgagg ctctcttcaa 813 caagtactgc gcgctcactc ttaaagagta gcccgcgccc gcccacacac ggaaaaaggc 873 gggaattacg tcaccacctg cgcccttcgc ccgaccatca tgagcaaaga gattcccacg 933 ccttacatgt ggagctacca gccccagatg ggcctggccg ccggcgccgc ccaggactac 993 tccacccgca tgaactggct cagtgccggg cccgcgatga tctcacgggt gaatgacatc 1053 cgcgcccgcc gaaaccagat actcctagaa cagtcagcga tcaccgccac gccccgccat 1113 caccttaatc cgcgtaattg gcccgccgcc ctggtgtacc aggaaattcc ccagcccacg 1173 accgtactac ttccgcgaga cgcccaggcc gaagtccagc tgactaactc aggtgtccag 1233 ctggccggcg gcgccgccct gtgtcgtcac cgccccgctc agggtataaa gcggctggtg 1293 atccgaggca gaggcacaca gctcaacgac gaggtggtga gctcttcgct gggtctgcga 1353 cctgacggag tcttccaact cgccggatcg gggagatctt ccttcacgcc tcgtcaggcc 1413 gtcctgactt tggagagttc gtcctcgcag ccccgctcgg gcggcatcgg cactctccag 1473 ttcgtggagg agttcactcc ctcggtctac ttcaacccct tctccggctc ccccggccac 1533 tacccggacg agttcatccc gaacttcgac gccatcagcg agtcggtgga cggctacgat 1593 tgaatgtccc atggtggcgc agctgaccta gctcggcttc gacacctgga ccactgccgc 1653 cgcttccgct gcttcgctcg ggatctcgcc gagtttgcct actttgagct gcccgaggag 1713 caccctcagg gcccagccca cggagtgcgg atcatcgtcg aagggggcct cgactcccac 1773 ctgcttcgga tcttcagcca gcgaccgatc ctggtcgagc gcgaacaagg acagacccgt 1833 ctgaccctgt actgcatctg caaccacccc ggcctgc atg aaa gtc ttt gtt gtc 1888 Met Lys Val Phe Val Val 190 tgc tgt gta ctg agt ata ata aaa gct gag atc agc gac tac tcc gga 1936 Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly 195 200 205 210 ctc gat tgt ggt gtt cct gct atc aac cgg tcc ctg ttc ttc acc ggg 1984 Leu Asp Cys Gly Val Pro Ala Ile Asn Arg Ser Leu Phe Phe Thr Gly 215 220 225 aac gaa acc gag ctc cag ctc cag tgt aag ccc cac aag aag tac ctc 2032 Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys Tyr Leu 230 235 240 acc tgg ctg ttc cag ggc tcc ccc atc gcc gtt gtc aac cac tgc gac 2080 Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn His Cys Asp 245 250 255 aac gac gga gtc ctg ctg agc ggc cct gcc aac ctt act ttt tcc acc 2128 Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr Phe Ser Thr 260 265 270 cgc aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc ggg acc tat 2176 Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro Gly Thr Tyr 275 280 285 290 cag tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg aat 2224 Gln Cys Val Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro Asn 295 300 305 acc aca gcg ccg ctc ccc gct act aac aac caa act aac ctc cac caa 2272 Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn Gln Thr Asn Leu His Gln 310 315 320 cgc cac cgt cgc gac ctt tcc tct gaa tct aat acc act acc gga ggt 2320 Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr Gly Gly 325 330 335 gag ctc cga ggt cga cca acc tct ggg att tac tac ggc ccc tgg gag 2368 Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly Pro Trp Glu 340 345 350 gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt ggg ctt ttg gct 2416 Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly Leu Leu Ala 355 360 365 370 ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta gtg gtg ctg tgt 2464 Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val Val Leu Cys 375 380 385 tgc tgg ttt aag aaa tgg ggc aga tca ccc tagtgagctg cggtgtgctg 2514 Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 390 395 gtggcggtgc tttcgattgt gggactgggc ggcgcggctg tagtgaagga ggagaaggcc 2574 gatccctgct tgcatttcaa tcccgacaaa tgccagctga gttttcagcc cgatggcaat 2634 cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat cgagtacaat 2694 aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc ccggggaccc cgagtggtac 2754 accgtctctg tccccggtgc tgacggctcc ccgcgcaccg tgaataatac tttcattttt 2814 gcgcacatgt gcaacacggt catgtggatg agcaagcagt acgatatgtg gccccccacg 2874 aaggagaaca tcgtggtctt ctccatcgct tacagcctgt gcacggcgct aatcaccgct 2934 atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa tgccgagaaa 2994 gagaaacagc cataacacgt tttttcacac accttgtttt tacagacaat gcgtctgtta 3054 aattttttaa acattgtgct cagtattgct tatgcctctg gttatgcaaa catacagaaa 3114 accctttatg taggatctga tggtacacta gagggtaccc aatcacaagc caaggttgca 3174 tggtattttt atagaaccaa cactgatcca gttaaacttt gtaagggtga attgccgcgt 3234 acacataaaa ctccacttac atttagttgc agcaataata atcttacact tttttcaatt 3294 acaaaacaat atactggtac ttattacagt acaaactttc atacaggaca agataaatat 3354 tatactgtta aggtagaaaa tcctaccact cctagaacta ccaccaccac caccactact 3414 gcaaagccca ctgtgaaaac tacaactagg accaccacaa ctacagaaac caccaccagc 3474 acaacacttg ctgcaactac acacacacac actaagctaa ccttacagac cactaatgat 3534 ttgatcgccc tgctgcaaaa gggggataac agcaccactt ccaatgagga gatacccaaa 3594 tccatgattg gcattattgt tgctgtagtg gtgtgcatgt tgatcatcgc cttgtgcatg 3654 gtgtactatg ccttctgcta cagaaagcac agactgaacg acaagctgga acacttacta 3714 agtgttgaat tttaattttt tagaaccatg aagatcctag gcctttttag tttttctatc 3774 attacctctg ctctttgtga atcagtggat agagatgtta ctattaccac tggttctaat 3834 tatacactga aagggccacc ctcaggtatg ctttcgtggt attgctattt tggaactgac 3894 actgatcaaa ctgaattatg caattttcaa aaaggcaaaa cctcaaactc taaaatctct 3954 aattatcaat gcaatggcac tgatctgata ctactcaatg tcacgaaagc atatggtggc 4014 agttattatt gccctggaca aaacactgaa gaaatgattt tttacaaagt ggaagtggtt 4074 gatcccacta caccacccac caccacaact attcatacca cacacacaga acaaacacca 4134 gaggcaacag aagcagagtt ggccttccag gttcacggag attcctttgc tgtcaatacc 4194 cctacacccg atcagcggtg tccggggccg ctagtcagcg gcattgtcgg tgtgctttcg 4254 ggattagcag tcataatcat ctgcatgttc atttttgctt gctgctatag aaggctttac 4314 cgacaaaaat cagacccact gctgaacctc tatgtttaat tttttccaga gccatgaagg 4374 cagttagcgc tctagttttt tgttctttga ttggcattgt ttttaatagt aaaattacca 4434 aagttagctt tattaaacat gttaatgtaa ctgaaggaga taacatcaca ctagcaggtg 4494 tagaaggtgc tcaaaacacc acctggacaa aataccatct aggatggaga gatatttgca 4554 cctggaatgt aacttattat tgcataggaa ttaatcttac cattgttaac gctaaccaat 4614 ctcagaatgg gttaattaaa ggacagagtg ttagtgtgac cagtgatggg tactataccc 4674 agcatagttt taactacaac attactgtca taccactgcc tacgcctagc ccacctagca 4734 ctaccacaca gacaaccaca tacagtacat caaatcagcc taccaccact acagcagcag 4794 aggttgccag ctcgtctggg gtccgagtgg catttttgat gttggcccca tctagcagtc 4854 ccactgctag taccaatgag cagactactg aatttttgtc cactgtcgag agccacacca 4914 cagctacctc cagtgccttc tctagcaccg ccaatctctc ctcgctttcc tctacaccaa 4974 tcagccccgc tactactcct agccccgctc ctcttcccac tcccctgaag caaacagacg 5034 gcggcatgca atggcagatc accctgctca ttgtgatcgg gttggtcatc ctggccgtgt 5094 tgctctacta catcttctgc cgccgcattc ccaacgcgca ccgcaagccg gcctacaagc 5154 ccatcgttat cgggcagccg gagccgcttc aggtggaagg gggtctaagg aatcttctct 5214 tctcttttac agtatggtga ttgaactatg attcctagac aattcttgat cactattctt 5274 atctgcctcc tccaagtctg tgccaccctc gctctggtgg ccaacgccag tccagactgt 5334 attgggccct tcgcctccta cgtgctcttt gccttcatca cctgcatctg ctgctgtagc 5394 atagtctgcc tgcttatcac cttcttccag ttcattgact ggatctttgt gcgcatcgcc 5454 tacctgcgcc accaccccca gtaccgcgac cagcgagtgg cgcagctgct caggctcctc 5514 tgataagcat gcgggctctg ctacttctcg cgcttctgct gttagtgctc ccccgtcccg 5574 ttgacccccg gccccccact cagtcccccg aggaggtccg caaatgcaaa ttccaagaac 5634 cctggaaatt cctcaaatgc taccgccaaa aatcagacat gcatcccagc tggatcatga 5694 tcattgggat cgtgaacatt ctggcctgca ccctcatctc ctttgtgatt tacccctgct 5754 ttgactttgg ttggaactcg ccagaggcgc tctatctccc gcctgaacct gacacaccac 5814 cacagcaacc tcaggcacac gcactaccac caccaccaca gcctaggcca caatacatgc 5874 ccatattaga ctatgaggcc gagccacagc gacccatgct ccccgctatt agttacttca 5934 atctaaccgg cggag atg act gac cca ctg gcc aac aac aac gtc aac gac 5985 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp 400 405 ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa 6033 Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln 410 415 420 ctt cgc att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac 6081 Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp 425 430 435 440 ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa 6129 Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys 445 450 455 cag gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc ctc tcc 6177 Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser 460 465 470 tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg gtc gga gtc 6225 Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val 475 480 485 aac ccc atc gtc atc acc cag cag tcg ggc gat acc aag ggg tgc atc 6273 Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile 490 495 500 cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act ctg atc aag acc 6321 His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr 505 510 515 520 ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac taatca 6360 Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 525 530 <210> 58 <211> 188 <212> PRT <213> Simian adenovirus 37 <400> 58 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu 165 170 175 Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser 180 185 <210> 59 <211> 208 <212> PRT <213> Simian adenovirus 37 <400> 59 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Asn Leu His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser 130 135 140 Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile 145 150 155 160 Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 165 170 175 Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser 180 185 190 Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 60 <211> 135 <212> PRT <213> Simian adenovirus 37 <400> 60 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 61 <211> 870 <212> DNA <213> Simian adenovirus 37 <220> <221> CDS <222> (7)..(574) <223> label=Ela <220> <221> CDS <222> (660)..(865) <223> label=Ela <400> 61 tgaaag atg agg cac ctg aga gac ctg ccc ggt aat gtt ttc ctg gct 48 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala 1 5 10 act ggg aac gag att ctg gaa ctg gtg gtg gac gcc atg atg ggt gac 96 Thr Gly Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp 15 20 25 30 gac cct ccc gag ccc cct acc cca ttt gag gcg cct tcg ctg tac gat 144 Asp Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp 35 40 45 ttg tat gat ctg gag gtg gat gtg tcc gag aac gac ccc aac gag gag 192 Leu Tyr Asp Leu Glu Val Asp Val Ser Glu Asn Asp Pro Asn Glu Glu 50 55 60 gcg gtg aat gat ttg ttt agc gat gcc gcg ctg ctg gct gcc gag cag 240 Ala Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln 65 70 75 gct aat acg gac tct ggc tca gac agc gat tcc tct ctc cat acc ccg 288 Ala Asn Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro 80 85 90 aga ccc ggc aga ggt gag aaa aag atc ccc gag ctt aaa ggg gaa gag 336 Arg Pro Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu 95 100 105 110 ctc gac ctg cgc tgc tat gag gaa tgc ttg cct ccg agc gat gat gag 384 Leu Asp Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu 115 120 125 gag gac gag gag gcg att cga gct gca gcg agc gag gga gtg aaa gtt 432 Glu Asp Glu Glu Ala Ile Arg Ala Ala Ala Ser Glu Gly Val Lys Val 130 135 140 gcg ggc gag agc ttt agc ctg gac tgt cct act ctg ccc gga cac ggc 480 Ala Gly Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly 145 150 155 tgt aag tct tgt gaa ttt cat cgc atg aat act gga gat aag aat gtg 528 Cys Lys Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val 160 165 170 atg tgt gcc ctg tgc tat atg aga gct tac aac cat tgt gtt tac a 574 Met Cys Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr 175 180 185 gtaagtgtga ttaactttag ttgggaaagg cagagggtga ctgggtgctg actggtttat 634 ttatgtatat gttttttatg tgtag gt ccc gtc tct gac gca gat gag acc 685 Ser Pro Val Ser Asp Ala Asp Glu Thr 195 ccc act tca gag tgc att tca tca ccc cca gaa att ggc gag gaa ccg 733 Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro Glu Ile Gly Glu Glu Pro 200 205 210 ccc gaa gat att att cat aga cca gtt gca gtg aga gtc acc ggg cgg 781 Pro Glu Asp Ile Ile His Arg Pro Val Ala Val Arg Val Thr Gly Arg 215 220 225 230 aga gca gct gtg gag agt ttg gat gac ttg cta cag ggt ggg gat gaa 829 Arg Ala Ala Val Glu Ser Leu Asp Asp Leu Leu Gln Gly Gly Asp Glu 235 240 245 cct ttg gac ttg tgt acc cgg aaa cgc ccc agg cac taagt 870 Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg His 250 255 <210> 62 <211> 258 <212> PRT <213> Simian adenovirus 37 <400> 62 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Ser Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Ala Ile Arg Ala Ala Ala Ser Glu Gly Val Lys Val Ala Gly 130 135 140 Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val 180 185 190 Ser Asp Ala Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro 195 200 205 Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val Ala 210 215 220 Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp Leu 225 230 235 240 Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro 245 250 255 Arg His <210> 63 <211> 850 <212> DNA <213> Simian adenovirus 37 <220> <221> CDS <222> (10)..(337) <223> label=33K <220> <221> CDS <222> (507)..(841) <223> label=33K <400> 63 tcccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 51 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag 99 Pro Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 147 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa 195 Asp Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu 50 55 60 gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca agc agc acg 243 Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 291 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 agg tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc g 337 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 95 100 105 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 397 gcttgcaagc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 457 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 514 Ala Pro Thr act gtt tcc aag aag agg cag aaa ccc agc agc agc aga aaa cca gcg 562 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 gca gca gca gct aga aaa tcc aca gcg gcg gca ggt gga ctg agg atc 610 Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile 130 135 140 gcg gcg aac gag ccg gcg cag acc cgg gag ctg agg aac cgg atc ttt 658 Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe 145 150 155 160 ccc acc ctc tat gcc atc ttc cag cag agt cgg ggg cag gag cag gaa 706 Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu 165 170 175 ctg aaa gtc aag aac cgt tct ctg cgc tcg ctc acc cgc agt tgt ctg 754 Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu 180 185 190 tat cac aag agc gaa gac caa ctt cag cgc act ctc gag gac gcc gag 802 Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu 195 200 205 gct ctc ttc aac aag tac tgc gcg ctc act ctt aaa gag tagcccgcg 850 Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 64 <211> 221 <212> PRT <213> Simian adenovirus 37 <400> 64 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro Thr 100 105 110 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile 130 135 140 Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe 145 150 155 160 Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu 165 170 175 Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu 180 185 190 Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu 195 200 205 Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 65 <211> 36494 <212> DNA <213> Simian adenovirus 38 <220> <221> repeat_region <222> (1)..(130) <223> label=ITR <220> <221> CDS <222> (1906)..(3417) <223> label=Elb\55K <220> <221> CDS <222> (3505)..(3930) <223> label=pIX <220> <221> misc_feature <222> (3996)..(5617) <223> complement (3996..5326, 5605..5617) label=IVa2 <220> <221> misc_feature <222> (5099)..(13873) <223> complement (5099..8671, 13865..13873) label=pol <220> <221> misc_feature <222> (8473)..(13873) <223> complement (8473..10410, 13865..13873) label=pTP <220> <221> misc_feature <222> (10444)..(10608) <223> label=VA\I <220> <221> misc_feature <222> (10673)..(10843) <223> label=VA\II <220> <221> CDS <222> (10871)..(12046) <223> label=52\55K <220> <221> CDS <222> (12073)..(13830) <223> label=pIIIa <220> <221> CDS <222> (13913)..(15529) <223> label=penton <220> <221> CDS <222> (15536)..(16117) <223> label=pVII <220> <221> CDS <222> (16165)..(17211) <223> label=V <220> <221> CDS <222> (17239)..(17469) <223> label=pX <220> <221> CDS <222> (17542)..(18261) <223> label=pVI <220> <221> CDS <222> (18357)..(21146) <223> label=hexon <220> <221> CDS <222> (21171)..(21791) <223> label=protease <220> <221> misc_feature <222> (21869)..(23404) <223> complement label=DBP <220> <221> CDS <222> (23430)..(25814) <223> label=100K <220> <221> CDS <222> (26452)..(27132) <223> label=pVIII <220> <221> CDS <222> (27136)..(27453) <223> label=E3\12.5K <220> <221> CDS <222> (28581)..(29198) <223> label=E3\CR1\beta <220> <221> CDS <222> (29214)..(29822) <223> label=E3\CR1\gamma <220> <221> CDS <222> (29840)..(30703) <223> label=E3\CR1\delta <220> <221> CDS <222> (30714)..(30986) <223> label=E3\RID\alpha <220> <221> CDS <222> (31419)..(31823) <223> label=E3\14.7K <220> <221> CDS <222> (32096)..(33370) <223> label=fiber <220> <221> misc_feature <222> (33485)..(33676) <223> complement label=E4\orf7 <220> <221> misc_feature <222> (33485)..(34635) <223> complement (33485..33733, 34465..34635) label=E4\orf6/7 <220> <221> misc_feature <222> (33733)..(34635) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34544)..(34906) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (34919)..(35269) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35269)..(35655) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35699)..(36070) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36365)..(36494) <223> complement label=ITR <400> 65 catcatcaaa taatatacct taaacttttg gtgcgcgtta atatgcaaat gaggtatttg 60 aatttgggga tgcggggcgg tgattggctg cgggagcggc gaccgttagg ggcggggcgg 120 gtgacgtttt gatgacgtgt ttgtgaggcg gagccggttt gcaagttctc gtgggaaaag 180 tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac 240 aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact 300 gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga 360 gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtattt ttcacctaaa 420 tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg tgtcagctga tcgccagggt 480 atttaaacct gcgctctcta gtcaagaggc cactcttgag tgccagcgag tagagttttc 540 tcctccgcgc cgcgagtcag atctacactt tgaaagatga ggcacctgag agacctgccc 600 ggtaatgttt tcctggctac tgggaacgag attctggaac tggtggtgga cgccatgatg 660 ggtgacgacc ctccggagcc ccctacccca tttgaggcgc cttcgctgta cgatttgtat 720 gatctggagg tggatgtgcc cgagaacgac cccaacgagg aggcggtgaa tgatttgttt 780 agcgatgccg cgctgctggc tgccgagcag gctaatacgg actctggctc agacagcgat 840 tcctctctcc ataccccgag acccggcaga ggtgagaaaa agatccccga gcttaaaggg 900 gaagagctcg acctgcgctg ctatgaggaa tgcttgcctc cgagcgatga tgaggaggac 960 gaggaggcga ttcgagctgc agcgaaccag ggagtgaaag cggcgggcga gggctttagc 1020 ctggactgtc ctactctgcc cggacacggc tgtaagtctt gtgaatttca tcgcatgaat 1080 actggagata agaatgtgat gtgtgccctg tgctatatga gagcttacaa ccattgtgtt 1140 tacagtaagt gtgattaact ttagttggga aggcagaggg tgactgggtg ctgactggtt 1200 tatttatgta tatgtttttt tatgtgtagg tcccgtctct gacgtagatg agacccccac 1260 ttcagagtgc atttcatcac ccccagaaat tggcgaggaa ccgcccgaag atattattca 1320 tagaccagtt gcagtgagag tcaccgggcg gagagcagct gtggagagtt tggatgactt 1380 gctacagggt ggggatgaac ctttggactt gtgtacccgg aaacgcccca ggcactaagt 1440 gccacacatg tgtgtttact taaggtgatg tcagtattta tagggtgtgg agtgcaataa 1500 aatccgtgtt gactttaagt gcgtgtttta tgactcaggg gtggggactg tgggtatata 1560 agcaggtgca gacctgtgtg gtcagttcag agcaggactc atggagatct ggacggtctt 1620 ggaagacttt catcagacta gacagctgct agagaactca tcggaggaag tctcttacct 1680 gtggagattt tgcttcggtg gggctctagc taagctagtc tatagggcca aacaggatta 1740 taaggatcaa tttgaggata ttttgagaga gtgtcctggt atttttgact ctctcaactt 1800 gggccatcag tctcacttta accagagtat tctgagagcc cttgactttt ctactcctgg 1860 cagaactacc gccgcggtag ccttttttgc ctttatcctt gacaa atg gag tca aga 1917 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1965 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2013 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2061 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2109 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc 2157 Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser 70 75 80 ggt ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg 2205 Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 100 gtg ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag 2253 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 105 110 115 agg cat gag gag act agc cac aga act gaa ctg act gtc agt ctg atg 2301 Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met 120 125 130 agc cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtg cag tcg cag 2349 Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln 135 140 145 ggg ata gat gag gtc tca gtg atg cat gag aaa tat tcc cta gaa caa 2397 Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln 150 155 160 gtc aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc 2445 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile 165 170 175 180 agg aat tat gcc aag ctg gct ctg aag cca gac aag aag tac aag att 2493 Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys Lys Tyr Lys Ile 185 190 195 acc aaa ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg 2541 Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly 200 205 210 gcc gag gtg gag atc agt acc cag gag agg gcg gcc ttc aga tgt tgt 2589 Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Ala Ala Phe Arg Cys Cys 215 220 225 atg atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt 2637 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe 230 235 240 atg aac acg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg 2685 Met Asn Thr Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met 245 250 255 260 gcc aac acc aag ttg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat 2733 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 265 270 275 aac atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc 2781 Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser 280 285 290 ttt tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc gtg gtt 2829 Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Val Val 295 300 305 tca gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc 2877 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 310 315 320 gag ggc gaa gcc aaa gtc aaa cac tgc gcc tct act gag acg ggc tgc 2925 Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 340 ttt gtg ctg atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt 2973 Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys 345 350 355 ggg gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg 3021 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 360 365 370 aac agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag 3069 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys 375 380 385 aca tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac 3117 Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His 390 395 400 ctg ggg tcc cgc cga ggc atg ttc atg ccc tac cag tgc aac atg caa 3165 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln 405 410 415 420 ttt gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg 3213 Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 425 430 435 acg ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat 3261 Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr 440 445 450 gat gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac 3309 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 455 460 465 gcc agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc 3357 Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro 470 475 480 gat cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg 3405 Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 500 gaa gaa tct gac tagagtgagt agtgtttggg ggaggtggag ggcttgtatg 3457 Glu Glu Ser Asp aggggcagaa tgactaaaat ctgtgttttt ctgtgtgttg cagcagc atg agc gga 3513 Met Ser Gly 505 agc gcc tcc ttt gag gga ggg gta ttc agc ccg tat ctg acg ggg cgt 3561 Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg 510 515 520 ctc ccc tcc tgg gct gga gtg cgt cag aat gtg atg gga tcc acg gtg 3609 Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser Thr Val 525 530 535 gac ggc cgg ccc gtg cag ccc gcg aac tct tca acc ctg acc tac gcg 3657 Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala 540 545 550 555 acc ctg agc tcc tcg tcc gtg gac gca gct gcc gcc gca gct gct gct 3705 Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala Ala Ala 560 565 570 tcc gcc gcc agc gcc gtg cgc gga atg gcc ctg ggc gcc ggc tac tac 3753 Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly Tyr Tyr 575 580 585 agc tct ctg gtg gcc aac tcg agt tcc acc aat aat ccc gcc agc ctg 3801 Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu 590 595 600 aac gag gag aag ctg ctg ctg ctg atg gcc cag ctc gag gcc ctg acc 3849 Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala Leu Thr 605 610 615 cag cgc ctg ggc gag ctg acc cag cag gtg gct cag ctg cag gcg gag 3897 Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln Ala Glu 620 625 630 635 acg cgg gcc gcg gtt gcc acg gtg aaa acc aaa taaaaaatga atcaataaat 3950 Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 640 645 aaacggagac ggttgttgat tttaacacag agtcttgaat ctttatttga tttttcgcgc 4010 gcggtaggcc ctggaccacc ggtctcgatc attgagcacc cggtggatct tttccaggac 4070 ccggtagagg tgggcttgga tgttgaggta catgggcatg agcccgtccc gggggtggag 4130 gtagctccat tgcagggcct cgtgctcggg ggtggtgttg taaatcaccc agtcatagca 4190 ggggcgcagt gcgtggtgct gcacgatgtc cttgaggagg agactgacgg ccacgggcag 4250 ccccttggtg taggtgttga cgaacctgtt gagctgggag ggatgcatgc ggggggagat 4310 gagatgcatc ttggcctgga tcttgagatt ggcgatgttc ccgcccagat cccgccgggg 4370 gttcatgttg tgcaggacca ccagcacggt gtatccggtg cacttgggga atttgtcatg 4430 caacttggaa gggaaggcgt gaaagaattt ggagacgccc ttgtggccgc ccaggttttc 4490 catgcactca tccatgatga tggcgatggg cccgtgggcg gcggcctggg caaagacgtt 4550 tcgggggtcg gacacatcgt agttgtggtc ctgggtgagc tcgtcatagg ccattttaat 4610 gaatttgggg cggagggtgc ccgactgggg gacgaaggtg ccctcgatcc cgggggcgta 4670 gttgccctcg cagatctgca tctcccaggc cttgagctcg gaggggggga tcatgtccac 4730 ctgcggggcg atgaaaaaaa cggtttccgg ggcgggggag atgagctggg ccgaaagcag 4790 gttccggagc agctgggact tgccgcagcc ggtgggaccg tagatgaccc cgatgaccgg 4850 ctgcaggtgg tagttgaggg agagacagct gccgtcctcg cggaggaggg gggccacctc 4910 gttcatcatc tcgcgcacat gcatgttctc gcgcacgagt tccgccagga ggcgctcgcc 4970 ccccagcgag aggagctctt gcagcgaggc gaagtttttc agcggcttga gcccgtcggc 5030 catgggcatt ttggagaggg tctgttgcaa gagttccaga cggtcccaga gctcggtgat 5090 gtgctctagg gcatctcgat ccagcagacc tcctcgtttc gcgggttggg gcgactgcgg 5150 gagtagggca ccaggcgatg ggcgtccagc gaggccaggg tccggtcctt ccagggccgt 5210 agggtccgcg tcagcgtggt ctccgtcacg gtgaaggggt gcgcgccggg ctgggcgctt 5270 gcgagggtgc gcttcaggct catccggctg gtcgagaacc gctcccggtc ggcgccctgc 5330 gcgtcggcca ggtagcaatt gagcatgagt tcgtagttga gcgcctcggc cgcgtggccc 5390 ttggcgcgga gcttaccttt ggaagtgtgt ccgcagacgg gacagaggag ggacttgagg 5450 gcgtagagct tgggggcgag gaagacggac tcgggggcgt aggcgtccgc gccgcagctg 5510 gcgcagacgg tctcgcactc cacgagccag gtgaggtcgg ggcggtcggg gtcaaaaacg 5570 aggtttcctc cgtgcttttt gatgcgtttc ttacctctgg tctccatgag ctcgtgtccc 5630 cgctgggtga caaagaggct gtccgtgtcc ccgtagaccg actttatggg ccggtcctcg 5690 agcggggtgc cgcggtcctc gtcgtagagg aaccccgccc actccgagac gaaggcccgg 5750 gtccaggcca gcacgaagga ggccacgtgg gaggggtagc ggtcgttgtc caccagcggg 5810 tccaccttct ccagggtatg caagcacatg tccccctcgt ccacatccag gaaggtgatt 5870 ggcttgtaag tgtaggccac gtgaccgggg gtcccggccg ggggggtata aaagggggcg 5930 ggcccctgct cgtcctcact gtcttccgga tcgctgtcca ggagcgccag ctgttggggt 5990 aggtattccc tctcgaaggc gggcatgacc tcggcactca ggttgtcagt ttctagaaac 6050 gaggaggatt tgatattgac ggtgccgttg gagacgcctt tcatgagccc ctcgtccatc 6110 tggtcagaaa agacgatctt tttgttgtcg agcttggtgg cgaaggagcc gtagagggca 6170 ttggagagga gcttggcgat ggagcgcatg gtctggttct tttccttgtc ggcgcgctcc 6230 ttggcggcga tgttgagctg cacgtactcg cgcgccacgc acttccattc ggggaagacg 6290 gtggtgagct cgtcgggcac gattctgacc cgccagccgc ggttgtgcag ggtgatgagg 6350 tccacgctgg tggccacctc gccgcgcagg ggctcgttgg tccagcagag gcgcccgccc 6410 ttgcgcgagc agaagggggg cagcgggtcc agcatgagct cgtcgggggg gtcggcgtcc 6470 acggtgaaga tgccgggcag gagctcgggg tcgaagtagc tgatgcaggt gcccagatcg 6530 tccagcgccg cttgccagtc gcgcacggcc agcgcgcgct cgtaggggct gaggggcgtg 6590 ccccagggca tggggtgcgt gagcgcggag gcgtacatgc cgcagatgtc gtagacgtag 6650 aggggctcct cgaggacgcc gatgtaggtg gggtagcagc gccccccgcg gatgctggcg 6710 cgcacgtagt cgtacagctc gtgcgagggc gcgaggagcc ccgtgccgag attggagcgc 6770 tgcggctttt cggcgcggta gacgatctgg cggaagatgg cgtgggagtt ggaggagatg 6830 gtgggcctct ggaagatgtt gaagtgggcg tggggcaggc cgaccgagtc cctgatgaag 6890 tgggcgtagg agtcctgcag cttggcgacg agctcggcgg tgacgaggac gtccagggcg 6950 cagtagtcga gggtctcttg gatgatgtcg tacttgagct ggcccttctg cttccacagc 7010 tcgcggttga gaaggaactc ttcgcggtcc ttccagtact cttcgagggg gaacccgtcc 7070 tgatcggcac ggtaagagcc caccatgtag aactggttga cggccttgta ggcgcagcag 7130 cccttctcca cggggagggc ataagcttgc gcggccttgc gcagggaggt gtgggtgagg 7190 gcgaaggtgt cgcgcaccat gaccttgagg aactggtgct tgaagtcgag gtcgtcgcag 7250 ccgccctgct cccagagttg gaagtccgtg cgcttcttgt aggcggggtt gggcaaagcg 7310 aaagtaacat cgttgaagag gatcttgccc gcgcggggca tgaagttgcg agtgatgcgg 7370 aaaggctggg gcacctcggc ccggttgttg atgacctggg cggcgaggac gatctcgtcg 7430 aagccgttga tgttgtgccc gacgatgtag agttccacga atcgcgggcg gcccttgacg 7490 tggggcagct tcttgagctc gtcgtaggtg agctcggcgg ggtcgctgag gccgtgctgc 7550 tcgagggccc agtcggcgac gtgggggttg gcgctgagga aggaagtcca gagatccacg 7610 gccagggcgg tctgcaagcg gtcccggtat tgacggaact gctggcccac ggccattttt 7670 tcgggggtga cgcagtagaa ggtgcggggg tcgccgtgcc agcggtccca cttgagctgg 7730 agggcgaggt cgtgggcgag ctcgacgagc ggcgggtccc cggagagttt catgaccagc 7790 atgaagggga cgagctgctt gccgaaggac cccatccagg tgtaggtttc cacatcgtag 7850 gtgaggaaga gcctttcggt gcgaggatgc gagccgatgg ggaagaactg gatctcctgc 7910 caccagttgg aggaatggct gttgatgtga tggaagtaga aatgccgacg gcgcgccgag 7970 cactcgtgct tgtgtttata caagcgtccg cagtgctcgc aacgctgcac gggatgcacg 8030 tgctgcacga gctgtacctg agttcctttg acgaggaatt tcagtgggca gtggagcgct 8090 ggcggctgca tctggtgctg tactacgtcc tggccatcgg cgtggccatc gtctgcctcg 8150 atggtggtca tgctgacgag gccgcgcggg aggcaggtcc agacctcggc tcggacgggt 8210 cggagagcga ggacgagggc gcgcaggccg gagctgtcca gggtcctgag acgctgcgga 8270 gtcaggtcag tgggcagcgg cggcgcgcgg ttgacttgca ggagcttttc cagggcgcgc 8330 gggaggtcca gatggtactt gatctccacg gcgccgttgg tggcgacgtc cacggcttgc 8390 agggtcccgt gcccctgggg cgccaccacc gtgccccgtt tcttcttggg cgctggcgtt 8450 ggcgctgctt ccatgtcggt cagaagcggc ggcgaggacg cgcgccgggc ggcaggggcg 8510 gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg ggcaggttct 8570 ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg tcctggatct 8630 gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag agttcgacag 8690 aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg tcgcccgagt 8750 tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcctga aggtctccgc 8810 ggccggcgcg ctcgacggtg gccgcgaggt cgttggagat gcggcccatg agctgcgaga 8870 aggcgttcat gccggcctcg ttccagacgc ggctgtagac cacggatccg tcggggtcgc 8930 gcgcgcgcat gaccacctgg gcgaggttga gctccacgtg gcgcgtgaag accgcgtagt 8990 tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg acgaagaagt 9050 acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagggcttcc aagcgctcca 9110 tggcctcgta gaagtccacg gcgaagttga aaaactggga gttgcgcgcc gagacggtca 9170 actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacttcg cgctcgaagg 9230 ccccgggggg ctcctcctct tccatctcct cctcttcctc ctcctccact aacatctctt 9290 ctacttcctc ctcaggaggc ggcggcgggg gaggggccct gcgtcgccgg cggcgcacgg 9350 gcagacggtc gatgaagcgc tcgatggtct ccccgcgccg gcgacgcatg gtctcggtga 9410 cggcgcgccc gtcctcgcgg ggccgcagcg tgaagacgcc gccgcgcatc tccaggtggc 9470 cgccgggggg gtctccgttg ggcagggaga gggcgctgac gatgcatctt atcaattggc 9530 ccgtagggac tccgcgcaag gacctgagcg tctcgagatc cacgggatcc gaaaaccgct 9590 gaacgaaggc ttcgagccag tcgcagtcgc aaggtaggct gagcccggtt tcttgttctt 9650 cgggtatttg gtcgggaggc gggcgggcga tgctgctggt gatgaagttg aagtaggcgg 9710 tcctgagacg gcggatggtg gcgaggagca ccaggtcctt gggcccggct tgctggatgc 9770 gcagacggtc ggccatgccc caggcgtggt cctgacacct ggcgaggtcc ttgtagtagt 9830 cctgcatgag ccgctccacg ggcacctcct cctcgcccgc gcggccgtgc atgcgcgtga 9890 gcccgaaccc gcgctgcggc tggacgagcg ccaggtcggc gacgacgcgc tcggcgagga 9950 tggcctgctg gatctgggtg agggtggtct ggaagtcgtc gaagtcgacg aagcggtggt 10010 aggctccggt gttgatggtg taggagcagt tggccatgac ggaccagttg acggtctggt 10070 ggccggggcg cacgagctcg tggtacttga ggcgcgagta ggcgcgcgtg tcgaagatgt 10130 agtcgttgca ggtgcgcacg aggtactggt atccgacgag gaagtgcggc ggcggctggc 10190 ggtagagcgg ccatcgctcg gtggcggggg cgccgggcgc gaggtcttcg agcatgaggc 10250 ggtggtagcc gtagatgtac ctggacatcc aggtgatgcc ggcggcggtg gtggaggcgc 10310 gcgggaactc gcggacgcgg ttccagatgt tgcgcagcgg caggaagtag ttcatggtgg 10370 ccgcggtctg gcccgtgagg cgcgcgcagt cgtggatgct ctagacatac gggcaaaaac 10430 gaaagcggtc agcggctcga ctccgtggcc tggaggctaa gcgaacgggt tgggctgcgc 10490 gtgtaccccg gttcgagtcc ctgctcgaat caggctggag ccgcagctaa cgtggtactg 10550 gcactcccgt ctcgacccaa gcctgctaac gaaacctcca ggatacggag gcgggtcgtt 10610 ttggcgtttt ttcgtcaggc cggaaatgaa actagtaagc gcggaaagcg gccgcccgca 10670 atggctcgct gccgtagtct ggagaaagaa tcgccagggt tgcgttgcgg tgtgccccgg 10730 ttcgagactc agcgctcggc gccggccgga ttccgcggct aacgtgggcg tggctgcccc 10790 gtcgtttcca agacccctta gccagccgac ttctccagtt acggagcgag cccctctttt 10850 ttttcttgtg tttttgccag atg cat ccc gta ctg cgg cag atg cgc ccc cac 10903 Met His Pro Val Leu Arg Gln Met Arg Pro His 650 655 cct cca cca caa ccg ccc cta ccg cag cag cag caa cag ccg gcg ctt 10951 Pro Pro Pro Gln Pro Pro Leu Pro Gln Gln Gln Gln Gln Pro Ala Leu 660 665 670 ctg ccc ccg ccc cag cag cag cag cag cca gcc act acc gcg gcg gcc 10999 Leu Pro Pro Pro Gln Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala 675 680 685 gcc gtg agc gga gcc ggc gtt cag tat gac ctg gcc ttg gaa gag ggc 11047 Ala Val Ser Gly Ala Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly 690 695 700 705 gag ggg ctg gcg cgg ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc 11095 Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg 710 715 720 gtg cag atg aaa agg gac gct cgc gag gcc tac gtg ccc aag cag aac 11143 Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn 725 730 735 ctg ttc aga gac agg agc ggc gag gag ccc gag gag atg cgc gcc tcc 11191 Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser 740 745 750 cgc ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg gac cga aag cgg 11239 Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg 755 760 765 gtg ctg agg gac gag gat ttc gag gcg gac gag ctg acg ggg atc agc 11287 Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser 770 775 780 785 ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc acg gcg tac gag 11335 Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu 790 795 800 cag acc gtg aag gag gag agc aac ttt caa aaa tcc ttc aac aac cac 11383 Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His 805 810 815 gtg cgc acc ttg atc gcg cgc gag gag gtg acc ctg ggc ctg atg cat 11431 Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His 820 825 830 ctg tgg gac ctg ctg gag gcc atc gtg cag aac ccc acg agc aag ccg 11479 Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro 835 840 845 ctg acg gcg cag ctg ttt ctg gtg gtg cag cac agt cgg gac aac gag 11527 Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu 850 855 860 865 acg ttc agg gag gcg ctg ctg aat atc acc gag ccc gag ggc cgc tgg 11575 Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp 870 875 880 ctc ctg gac ctg gtg aac att ctg cag agc atc gtg gtg cag gag cgc 11623 Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg 885 890 895 ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac ttc tcg gtg ctg 11671 Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu 900 905 910 agc ctg ggc aag tac tac gct agg aag atc tac aag acc ccg tac gtg 11719 Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val 915 920 925 ccc ata gac aag gag gtg aag atc gat ggg ttt tac atg cgc atg acc 11767 Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr 930 935 940 945 ctg aaa gtg ctg acc ctg agc gac gat ctg ggg gtg tac cgc aac gac 11815 Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp 950 955 960 agg atg cac cgc gcg gtg agc gcc agc cgc cgg cgc gag ctg agc gac 11863 Arg Met His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp 965 970 975 cag gag ctg atg cac agc ctg cag cgg gcc ctg acc ggg gcc ggg acc 11911 Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr 980 985 990 gag ggg gag agc tac ttt gac atg ggc gcg gac ctg cgc tgg cag ccc 11959 Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro 995 1000 1005 agc cgc cgg gcc ttg gaa gct gcc ggc ggc gtg ccc tac gtg gag 12004 Ser Arg Arg Ala Leu Glu Ala Ala Gly Gly Val Pro Tyr Val Glu 1010 1015 1020 gag gtg gac gat gag gag gag gag ggc gag tac ctg gaa gac 12046 Glu Val Asp Asp Glu Glu Glu Glu Gly Glu Tyr Leu Glu Asp 1025 1030 1035 tgatggcgcg accgtatttt tgctag atg cag caa cag cca ccg cct cct 12096 Met Gln Gln Gln Pro Pro Pro Pro 1040 1045 gat ccc gcg atg cgg gcg gcg ctg cag agc cag ccg tcc ggc att 12141 Asp Pro Ala Met Arg Ala Ala Leu Gln Ser Gln Pro Ser Gly Ile 1050 1055 1060 aac tcc tcg gac gat tgg acc cag gcc atg caa cgc atc atg gcg 12186 Asn Ser Ser Asp Asp Trp Thr Gln Ala Met Gln Arg Ile Met Ala 1065 1070 1075 ctg acg acc cgc aat ccc gaa gcc ttt aga cag cag cct cag gcc 12231 Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln Gln Pro Gln Ala 1080 1085 1090 aac cgg ctc tcg gcc atc ctg gag gcc gtg gtg ccc tcg cgc tcg 12276 Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro Ser Arg Ser 1095 1100 1105 aac ccc acg cac gag aag gtg ctg gcc atc gtg aac gcg ctg gtg 12321 Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala Leu Val 1110 1115 1120 gag aac aag gcc atc cgc ggc gac gag gcc ggg ctg gtg tac aac 12366 Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr Asn 1125 1130 1135 gcg ctg ctg gag cgc gtg gcc cgc tac aac agc acc aac gtg cag 12411 Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 1140 1145 1150 acg aac ctg gac cgc atg gtg acc gac gtg cgc gag gcg gtg tcg 12456 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 1155 1160 1165 cag cgc gag cgg ttc cac cgc gag tcg aac ctg ggc tcc atg gtg 12501 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val 1170 1175 1180 gcg ctg aac gcc ttc ctg agc acg cag ccc gcc aac gtg ccc cgg 12546 Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg 1185 1190 1195 ggc cag gag gac tac acc aac ttc atc agc gcg ctg cgg ctg atg 12591 Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met 1200 1205 1210 gtg gcc gag gtg ccc cag agc gag gtg tac cag tcg ggg ccg gac 12636 Val Ala Glu Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp 1215 1220 1225 tac ttc ttc cag acc agt cgc cag ggc ttg cag acc gtg aac ctg 12681 Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu 1230 1235 1240 agc cag gct ttc aag aac ttg cag gga ctg tgg ggc gtg cag gcc 12726 Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu Trp Gly Val Gln Ala 1245 1250 1255 ccg gtc ggg gac cgc gcg acg gtg tcg agc ctg ctg acg ccg aac 12771 Pro Val Gly Asp Arg Ala Thr Val Ser Ser Leu Leu Thr Pro Asn 1260 1265 1270 tcg cgc ctg ctg ctg ctg ctg gtg gcg ccc ttc acg gac agc ggc 12816 Ser Arg Leu Leu Leu Leu Leu Val Ala Pro Phe Thr Asp Ser Gly 1275 1280 1285 agc gtg agc cgc gac tcg tac ctg ggc tac ctg ctt aac ctg tac 12861 Ser Val Ser Arg Asp Ser Tyr Leu Gly Tyr Leu Leu Asn Leu Tyr 1290 1295 1300 cgc gag gcc atc ggg cag gcg cac gtg gac gag cag acc tac cag 12906 Arg Glu Ala Ile Gly Gln Ala His Val Asp Glu Gln Thr Tyr Gln 1305 1310 1315 gag atc acc cac gtg agc cgc gcg ctg ggc cag gag gac ccg ggc 12951 Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln Glu Asp Pro Gly 1320 1325 1330 aac ctg gag gcc acc ctg aac ttc ctg ctg acc aac cgg tcg cag 12996 Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn Arg Ser Gln 1335 1340 1345 aag atc ccg ccc cag tac gcg ctg agc acc gag gag gag cgc atc 13041 Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu Arg Ile 1350 1355 1360 ctg cgc tac gtg cag cag agc gtg ggg ctg ttc ctg atg cag gag 13086 Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln Glu 1365 1370 1375 ggg gcc acg ccc agc gcc gcg ctc gac atg acc gcg cgc aac atg 13131 Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 1380 1385 1390 gag ccc agc atg tac gcc cgc aac cgc ccg ttc atc aat aag ctg 13176 Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 1395 1400 1405 atg gac tac ttg cat cgg gcg gcc gcc atg aac tcg gac tac ttt 13221 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe 1410 1415 1420 acc aac gcc atc ttg aac ccg cac tgg ctc ccg ccg ccc ggg ttc 13266 Thr Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe 1425 1430 1435 tac acg ggc gag tac gac atg ccc gac ccc aac gac ggg ttc ctg 13311 Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu 1440 1445 1450 tgg gac gac gtg gac agc agc gtg ttc tcg ccg cgc ccc acc acc 13356 Trp Asp Asp Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr 1455 1460 1465 acc gtg tgg aag aaa gag ggc ggg gac cgg cgg ccg tcc tcg gcg 13401 Thr Val Trp Lys Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala 1470 1475 1480 ctg tcc ggt cgc gcg ggt gct gcc gcg gcg gtg ccc gag gcc gcc 13446 Leu Ser Gly Arg Ala Gly Ala Ala Ala Ala Val Pro Glu Ala Ala 1485 1490 1495 agc ccc ttc ccg agc ctg ccc ttt tcg ctg aac agc gtg cgc agc 13491 Ser Pro Phe Pro Ser Leu Pro Phe Ser Leu Asn Ser Val Arg Ser 1500 1505 1510 agc gag ctg ggt cgg ctg acg cgg ccg cgc ctg ctg ggc gag gag 13536 Ser Glu Leu Gly Arg Leu Thr Arg Pro Arg Leu Leu Gly Glu Glu 1515 1520 1525 gag tac ctg aac gac tcc ttg ttg agg ccc gag cgc gag aaa aac 13581 Glu Tyr Leu Asn Asp Ser Leu Leu Arg Pro Glu Arg Glu Lys Asn 1530 1535 1540 ttc ccc aat aac ggg ata gag agc ctg gtg gac aag atg agc cgc 13626 Phe Pro Asn Asn Gly Ile Glu Ser Leu Val Asp Lys Met Ser Arg 1545 1550 1555 tgg aag acg tac gcg cac gag cac agg gac gag ccc cga gct agc 13671 Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu Pro Arg Ala Ser 1560 1565 1570 agc agc acc ggc gcc cgt aga cgc cag cgg cac gac agg cag cgg 13716 Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His Asp Arg Gln Arg 1575 1580 1585 gga ctg gtg tgg gac gat gag gat tcc gcc gac gac agc agc gtg 13761 Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val 1590 1595 1600 ttg gac ttg ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ctg 13806 Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu 1605 1610 1615 cgc ccc cgt atc ggg cgc ctg atg taagaatctg aaaaaataaa aaaacggtac 13860 Arg Pro Arg Ile Gly Arg Leu Met 1620 tcaccaaggc catggcgacc agcgtgcgtt cttctctgtt gtttgtagta gt atg 13915 Met 1625 atg agg cgc gtg tac ccg gag ggt cct cct ccc tcg tac gag agc 13960 Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1630 1635 1640 gtg atg cag cag gcg gtg gcg gcg gcg atg cag ccc ccg ctg gag 14005 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu 1645 1650 1655 gcg cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg cgg 14050 Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 1660 1665 1670 aac agc att cgt tac tcg gag ctg gca ccc ttg tac gat acc acc 14095 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr 1675 1680 1685 cgg ttg tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg ctg 14140 Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu 1690 1695 1700 aac tac cag aac gac cac agc aac ttc ctg acc acc gtg gtg cag 14185 Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln 1705 1710 1715 aac aac gat ttc acc ccc acg gag gcc agc acc cag acc atc aac 14230 Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn 1720 1725 1730 ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc atg 14275 Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met 1735 1740 1745 cac acc aac atg ccc aac gtg aac gag ttc atg tac agc aac aag 14320 His Thr Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn Lys 1750 1755 1760 ttc aag gcg cgg gtg atg gtc tcg cgc aag acc ccc aac ggg gtc 14365 Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly Val 1765 1770 1775 aca gta aca gat ggt agt cag gac gag ctg acc tac gag tgg gtg 14410 Thr Val Thr Asp Gly Ser Gln Asp Glu Leu Thr Tyr Glu Trp Val 1780 1785 1790 gag ttt gag ctg ccc gag ggc aac ttc tcg gtg acc atg acc atc 14455 Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile 1795 1800 1805 gat ctg atg aac aac gcc atc atc gac aac tac ttg gcg gtg gga 14500 Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Ala Val Gly 1810 1815 1820 cgg cag aac ggg gtg ctg gag agc gac atc ggc gtg aag ttc gac 14545 Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp 1825 1830 1835 acg cgc aac ttc cgg ctg ggc tgg gac ccc gtg acc gag ctg gtg 14590 Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu Leu Val 1840 1845 1850 atg ccg ggc gtg tac acc aac gag gcc ttc cac ccc gac atc gtc 14635 Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile Val 1855 1860 1865 ctg ctg ccc ggc tgc ggc gtg gac ttc acc gag agc cgc ctc agc 14680 Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 1870 1875 1880 aac ctg ctg ggc atc cgc aag cgg cag ccc ttc cag gag ggc ttc 14725 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe 1885 1890 1895 cag atc ctg tac gag gac ctg gag ggg ggc aac atc ccc gcg ctg 14770 Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 1900 1905 1910 ctg gac gtc gaa gcc tac gag aaa agc aag gag gag gcc gcc gca 14815 Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 1915 1920 1925 gcg gcg acc gcg gcc gtg gct act gct gcg acc acc gat gca gat 14860 Ala Ala Thr Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp 1930 1935 1940 gca gct act act acc agg ggc gat aca ttc gcc acc cag gcg gag 14905 Ala Ala Thr Thr Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu 1945 1950 1955 gaa gca gcc gcc cta gcg gcg acc gat gat agt gaa agt aag ata 14950 Glu Ala Ala Ala Leu Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile 1960 1965 1970 gtc atc aag ccg gtg gag aag gac agc aag gac agg agc tac aac 14995 Val Ile Lys Pro Val Glu Lys Asp Ser Lys Asp Arg Ser Tyr Asn 1975 1980 1985 gtt cta tcg gat gga aag aac acc gcc tac cgc agc tgg tac ctg 15040 Val Leu Ser Asp Gly Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu 1990 1995 2000 gcc tac aac tac ggc gac cct gag aag ggc gtg cgc tcc tgg acg 15085 Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr 2005 2010 2015 ctg ctc acc acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac 15130 Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr 2020 2025 2030 tgg tcg ctg ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc 15175 Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser 2035 2040 2045 acg cgt caa gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg 15220 Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu 2050 2055 2060 ccc gtc tac tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg 15265 Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser 2065 2070 2075 cag cag ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc 15310 Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg 2080 2085 2090 ttc ccc gag aac cag atc ctc gtc cgc ccg ccc gcg ccc acc att 15355 Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile 2095 2100 2105 acc acc gtc agt gaa aac gtt cct gct ctc aca gat cac ggg acc 15400 Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 2110 2115 2120 ctg ccg ctg cgc agc agt atc cgg gga gtc cag cgc gtg acc gtc 15445 Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val 2125 2130 2135 act gac gcc aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg 15490 Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu 2140 2145 2150 ggc gta gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg 15538 Gly Val Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met 2155 2160 tcc att ctc atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc 15583 Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 2165 2170 2175 gcg ccc agc aag atg tac gga ggc gct cgc caa cgc tcc acg caa 15628 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln 2180 2185 2190 cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc 15673 His Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala 2195 2200 2205 ctc aag ggc cgc gtg cgc tcg cgc acc acc gtc gac gac gtg atc 15718 Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile 2210 2215 2220 gac cag gtg gtg gcc gac gcg cgc aac tac acg ccc gcc gcc gcg 15763 Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala 2225 2230 2235 ccc gcc tcc acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac 15808 Pro Ala Ser Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp 2240 2245 2250 gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc 15853 Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala 2255 2260 2265 cgg cgg cac cgg agc acc ccc gcc atg cgc gcg gcg cga gcc ttg 15898 Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu 2270 2275 2280 ctg cgc agg gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg 15943 Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala 2285 2290 2295 gcc aga cgc gcg gcc tcc ggc agc agc agc gcc ggc agg acc cgc 15988 Ala Arg Arg Ala Ala Ser Gly Ser Ser Ser Ala Gly Arg Thr Arg 2300 2305 2310 aga cgc gcg gcc acg gcg gcg gcg gcg gcc atc gcc agc atg tcc 16033 Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser 2315 2320 2325 cgc ccg cgg cgc ggc aac gtg tac tgg gtg cgc gac gcc gcc acc 16078 Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr 2330 2335 2340 ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct cgc act tgaagatgct 16127 Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg Thr 2345 2350 2355 gacttcgcga tgttgatgtg tcccagcggc gaggagg atg tcc aag cgc aaa tac 16182 Met Ser Lys Arg Lys Tyr 2360 aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac ggc ccc 16227 Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly Pro 2365 2370 2375 gcg gcg gcg gtg aag gag gaa aga aag ccc cgc aag ctg aag cgg 16272 Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg 2380 2385 2390 gtc aaa aag gac aaa aag gag gag gaa gat gtg aac gga ctg gtg 16317 Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Val Asn Gly Leu Val 2395 2400 2405 gag ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc 16362 Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg 2410 2415 2420 ggg cgg aaa gtg aaa ccg gtg ctg cgg ccc ggc acc acg gtg gtc 16407 Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val 2425 2430 2435 ttc acg ccc ggc gag cgt tcc ggc tcc gcc tcc aag cgc tcc tac 16452 Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr 2440 2445 2450 gac gag gtg tac ggg gac gag gac atc ctc gag cag gcg gtc gag 16497 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Val Glu 2455 2460 2465 cgt ctg ggc gag ttt gcg tac ggc aag cgc agc cgc ccc gcg ccc 16542 Arg Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro 2470 2475 2480 ttg aaa gag gag gcg gtg tcc atc ccg ctg gac cac ggc aac ccc 16587 Leu Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro 2485 2490 2495 acg ccg agc ctg aag ccg gtg acc ctg cag cag gtg ctg cct ggt 16632 Thr Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Gly 2500 2505 2510 gcg gcg ccg cgc cgg ggc ttc aaa cgc gag ggc ggc gag gat ctg 16677 Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu 2515 2520 2525 tac ccg acc atg cag ctg atg gtg ccc aag cgc cag aag ctg gag 16722 Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu 2530 2535 2540 gac gtg ctg gag cac atg aag gtg gac ccc gag gtg cag ccc gag 16767 Asp Val Leu Glu His Met Lys Val Asp Pro Glu Val Gln Pro Glu 2545 2550 2555 gtc aag gtg cgg ccc atc aag cag gtg gct ccg ggc ctg ggc gtg 16812 Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val 2560 2565 2570 cag acc gtg gac atc aag atc ccc acg gag ccc atg gaa acg cag 16857 Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln 2575 2580 2585 acc gag ccc gtg aag ccc agc acc agc acc atg gag gtg cag acg 16902 Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln Thr 2590 2595 2600 gat ccc tgg atg ccg gcg ccg gct tcc acc acc acc acc cgc cga 16947 Asp Pro Trp Met Pro Ala Pro Ala Ser Thr Thr Thr Thr Arg Arg 2605 2610 2615 aga cgc aag tac ggc gcg gcc agc ctg ctg atg ccc aac tac gcg 16992 Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala 2620 2625 2630 ctg cat cct tcc atc atc ccc acg ccg ggc tac cgc ggc acg cgc 17037 Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 2635 2640 2645 ttc tac cgc ggc tac acc agc agc cgc cgc cgc aag acc acc acc 17082 Phe Tyr Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr 2650 2655 2660 cgc cgc cgt cgt cgc agc cgc cgc agc agc acc gcg act tcc gcc 17127 Arg Arg Arg Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser Ala 2665 2670 2675 gcc gcc ctg gtg cgg aga gtg tac cgc agc ggg cgc gag cct ctg 17172 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu 2680 2685 2690 acc ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att taactctgcc 17221 Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2695 2700 2705 gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc gtc ccc att 17271 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile 2710 2715 acg ggc tac cga gga aga aag ccg cgc cgt aga agg ctg acg ggg 17316 Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly 2720 2725 2730 aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc gcc atc agc 17361 Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg Ala Ile Ser 2735 2740 2745 aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc ccc atc atc 17406 Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile 2750 2755 2760 gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc gtg gcg gtg 17451 Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser Val Ala Val 2765 2770 2775 cag gcc tct cag cgc cac tgagacacag cttggaaaat ttgtaataaa 17499 Gln Ala Ser Gln Arg His 2780 aaaatggact gacgctcctg gtcctgtgat gtgtgttttt ag atg gaa gac atc 17553 Met Glu Asp Ile 2785 aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg ttt atg 17598 Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met 2790 2795 2800 ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg ggc gcc 17643 Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly Gly Ala 2805 2810 2815 ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc 17688 Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 2820 2825 2830 acg ctc aaa acc tat ggc aac aag gcg tgg aac agc agc aca ggg 17733 Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 2835 2840 2845 cag gcg ctg agg gaa aag ctg aaa gag cag aac ttc cag cag aag 17778 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys 2850 2855 2860 gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg gtg gtg gac ctg 17823 Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu 2865 2870 2875 gcc aac cag gcc gtg cag aaa cag atc aac agc cgc ctg gac gcg 17868 Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala 2880 2885 2890 gtc ccg ccc gcg ggg tcc gtg gag atg ccc cag gtg gag gag gag 17913 Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu 2895 2900 2905 ctg cct ccc ctg gac aag cgc ggc gac aag cga ccg cgt ccc gac 17958 Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp 2910 2915 2920 gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc ccg tac 18003 Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr 2925 2930 2935 gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc gtg gcg 18048 Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Val Ala 2940 2945 2950 cct ctg gcc acc ggg gtg ctg aaa ccc agc agc agc agc cag ccc 18093 Pro Leu Ala Thr Gly Val Leu Lys Pro Ser Ser Ser Ser Gln Pro 2955 2960 2965 gcg acc ctg gac ttg cct ccg cct cgc ccc tcc aca gtg gct aag 18138 Ala Thr Leu Asp Leu Pro Pro Pro Arg Pro Ser Thr Val Ala Lys 2970 2975 2980 ccc ctg ccg ccg gtg gcc gtc gcg tcg cgc gcc ccc cga ggc cgc 18183 Pro Leu Pro Pro Val Ala Val Ala Ser Arg Ala Pro Arg Gly Arg 2985 2990 2995 ccc cag gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg 18228 Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu 3000 3005 3010 gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaaagacac 18271 Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 3015 3020 tgtagcgctt aacttgcttg tctgtgtgta tatgtatgtc cgccgaccag aaggaggagg 18331 aagaggcgcg tcgccgagtt gcaag atg gcc acc cca tcg atg ctg ccc cag 18383 Met Ala Thr Pro Ser Met Leu Pro Gln 3025 3030 tgg gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg 18428 Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu 3035 3040 3045 agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc 18473 Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe 3050 3055 3060 agt ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac 18518 Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His 3065 3070 3075 gat gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg 18563 Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val 3080 3085 3090 ccc gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac 18608 Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr 3095 3100 3105 acg ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc 18653 Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr 3110 3115 3120 tac ttt gac atc cgc ggc gtg ctg gat cgg ggc ccc agc ttc aaa 18698 Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys 3125 3130 3135 ccc tac tcc ggc acc gcc tac aac agc ctg gct ccc aag gga gcg 18743 Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala 3140 3145 3150 ccc aac act tgc cag tgg aca tat act gat aac caa act gag aaa 18788 Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Asn Gln Thr Glu Lys 3155 3160 3165 aca gcc aca tat gga aat gca ccc gta gag ggc att aac att aca 18833 Thr Ala Thr Tyr Gly Asn Ala Pro Val Glu Gly Ile Asn Ile Thr 3170 3175 3180 aaa gat ggc att caa ctt gga act gac agc gat ggt cag gca atc 18878 Lys Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Gln Ala Ile 3185 3190 3195 tat gca gac gaa act tat cag ccc gaa cct cag gtg gga gat cct 18923 Tyr Ala Asp Glu Thr Tyr Gln Pro Glu Pro Gln Val Gly Asp Pro 3200 3205 3210 gaa tgg cat gat acc aca ggt aca gaa gaa aaa tat gga ggc aga 18968 Glu Trp His Asp Thr Thr Gly Thr Glu Glu Lys Tyr Gly Gly Arg 3215 3220 3225 gcg ctt aaa cct gcc acc gac atg aaa cct tgc tat ggc tct ttt 19013 Ala Leu Lys Pro Ala Thr Asp Met Lys Pro Cys Tyr Gly Ser Phe 3230 3235 3240 gcc aag cca act aat gtt aag gga ggt cag gcc aaa agc aga aca 19058 Ala Lys Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Ser Arg Thr 3245 3250 3255 aaa act gat gga aca act gag cct gat att gac atg gcc ttt ttt 19103 Lys Thr Asp Gly Thr Thr Glu Pro Asp Ile Asp Met Ala Phe Phe 3260 3265 3270 gat ggt aga aat gca aca aca gct ggt ttg act cca gaa att gtt 19148 Asp Gly Arg Asn Ala Thr Thr Ala Gly Leu Thr Pro Glu Ile Val 3275 3280 3285 ttg tat act gaa aat gtg gat ctg gaa act cca gat acc cat att 19193 Leu Tyr Thr Glu Asn Val Asp Leu Glu Thr Pro Asp Thr His Ile 3290 3295 3300 gta tac aag gca ggc aca gat gac agc agc tct tca att aat ttg 19238 Val Tyr Lys Ala Gly Thr Asp Asp Ser Ser Ser Ser Ile Asn Leu 3305 3310 3315 ggt cag cag tcc atg ccc aac aga ccc aac tac att ggg ttt aga 19283 Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg 3320 3325 3330 gac aac ttc att ggg ctc atg tac tac aac agc act ggc aat atg 19328 Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met 3335 3340 3345 ggc gta ctg gct ggt cag gcc tcc cag ctg aat gct gtg gtg gac 19373 Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp 3350 3355 3360 ttg cag gac aga aac acc gaa ctg tcc tac cag ctc ttg ctt gac 19418 Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp 3365 3370 3375 tct ctg ggt gac aga acc agg tat ttc agt atg tgg aat cag gcg 19463 Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln Ala 3380 3385 3390 gtg gac agt tat gac ccc gat gtg cgc att att gaa aat cac ggt 19508 Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly 3395 3400 3405 gtg gag gat gaa cta ccc aac tat tgc ttc ccc ctg aat gct gtg 19553 Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Ala Val 3410 3415 3420 ggt aga aca gat agt tat cag gga att aag ccc aat gga ggc gat 19598 Gly Arg Thr Asp Ser Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp 3425 3430 3435 cca gct aca tgg gcc aaa gat gaa agc gtc aat gat tct aat gaa 19643 Pro Ala Thr Trp Ala Lys Asp Glu Ser Val Asn Asp Ser Asn Glu 3440 3445 3450 ttg ggc aag ggc aat cct ttc gcc atg gag atc aac atc cag gcc 19688 Leu Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala 3455 3460 3465 aac ctg tgg cgg aac ttc ctc tac gcg aac gtg gcc ctg tac ctg 19733 Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu 3470 3475 3480 ccc gac tcc tac aag tac acg ccg gcc aac atc acg ctg ccc acc 19778 Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr 3485 3490 3495 aac acc aac acc tac gat tac atg aac ggc cgc gtg gtg gcg ccc 19823 Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro 3500 3505 3510 tcg ctg gtg gac gcc tac atc aac atc ggg gcg cgc tgg tcg ctg 19868 Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu 3515 3520 3525 gac ccc atg gac aac gtc aac ccc ttc aac cac cac cgc aac gcg 19913 Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala 3530 3535 3540 ggc ctg cgc tac cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg 19958 Gly Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val 3545 3550 3555 ccc ttc cac atc cag gtg ccc caa aag ttc ttc gcc atc aag agc 20003 Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser 3560 3565 3570 ctc ctg ctc ctg ccc ggg tcc tac acc tac gag tgg aac ttc cgc 20048 Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg 3575 3580 3585 aag gac gtc aac atg atc ctg cag agc tcc ctc ggc aac gac ctg 20093 Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu 3590 3595 3600 cgc acg gac ggg gcc tcc atc gcc ttc acc agc atc aac ctc tac 20138 Arg Thr Asp Gly Ala Ser Ile Ala Phe Thr Ser Ile Asn Leu Tyr 3605 3610 3615 gcc acc ttc ttc ccc atg gcg cac aac acc gcc tcc acg ctc gag 20183 Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu 3620 3625 3630 gcc atg ctg cgc aac gac acc aac gac cag tcc ttc aac gac tac 20228 Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr 3635 3640 3645 ctc tcg gcg gcc aac atg ctc tac ccc atc ccg gcc aac gcc acc 20273 Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr 3650 3655 3660 aac gtg ccc atc tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc 20318 Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg 3665 3670 3675 ggc tgg tcc ttc acg cgc ctc aag acc cgc gag acg ccc tcg ctc 20363 Gly Trp Ser Phe Thr Arg Leu Lys Thr Arg Glu Thr Pro Ser Leu 3680 3685 3690 ggc tcc ggg ttc gac ccc tac ttc gtc tac tcg ggc tcc atc ccc 20408 Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro 3695 3700 3705 tac ctc gac ggc acc ttc tac ctc aac cac acc ttc aag aag gtc 20453 Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val 3710 3715 3720 tcc atc acc ttc gac tcc tcc gtc agc tgg ccc ggc aac gac cgc 20498 Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg 3725 3730 3735 ctc ctg acg ccc aac gag ttc gaa atc aag cgc acc gtc gac gga 20543 Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly 3740 3745 3750 gag ggg tac aac gtg gcc cag tgc aac atg acc aag gac tgg ttc 20588 Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe 3755 3760 3765 ctg gtc cag atg ctg gcc cac tac aac atc ggc tac cag ggc ttc 20633 Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe 3770 3775 3780 tac gtg ccc gag ggc tac aag gac cgc atg tac tcc ttc ttc cgc 20678 Tyr Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg 3785 3790 3795 aac ttc cag ccc atg agc cgc cag gtc gtg gac gag gtc aac tac 20723 Asn Phe Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr 3800 3805 3810 aag gac tac cag gcc gtc acc ctg acc tac cag cat aac aac tcg 20768 Lys Asp Tyr Gln Ala Val Thr Leu Thr Tyr Gln His Asn Asn Ser 3815 3820 3825 ggc ttc gtc ggc tac ctc gcg ccc acc atg cgc cag ggt cag ccc 20813 Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro 3830 3835 3840 tac ccc gcc aac tac ccc tac ccg ctc atc ggc aag agc gcc gtc 20858 Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val 3845 3850 3855 gcc agc gtc acc cag aaa aag ttc ctc tgc gac cgg gtc atg tgg 20903 Ala Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp 3860 3865 3870 cgc atc ccc ttc tcc agc aac ttc atg tcc atg ggc gcg ctc acc 20948 Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr 3875 3880 3885 gac ctc ggc cag aac atg ctc tac gcc aac tcc gcc cac gcg cta 20993 Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu 3890 3895 3900 gac atg aat ttc gaa gtc gac ccc atg gat gag tcc acc ctt ctc 21038 Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu 3905 3910 3915 tat gtt gtc ttc gaa gtc ttc gac gtc gtc cga gtg cac cag ccc 21083 Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro 3920 3925 3930 cac cgc ggc gtc atc gag gcc gtc tac ctg cgc acg ccc ttc tcg 21128 His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser 3935 3940 3945 gcc ggc aac gcc acc acc taagccgctc ttgcttcttg caag atg acg gcc 21179 Ala Gly Asn Ala Thr Thr Met Thr Ala 3950 3955 tgt ggc tcc ggc gag cag gag ctc agg gcc atc ctc cgc gac ctg 21224 Cys Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Leu Arg Asp Leu 3960 3965 3970 ggc tgc ggg ccc tgc ttc ctg ggc acc ttc gac aag cgc ttc ccg 21269 Gly Cys Gly Pro Cys Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro 3975 3980 3985 gga ttc atg gcc ccg cac aag ctg gcc tgc gcc atc gtc aac acg 21314 Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr 3990 3995 4000 gcc ggc cgc gag acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg 21359 Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 4005 4010 4015 aac ccg cgc tcc cac acc tgc tac ctc ttc gac ccc ttc ggg ttc 21404 Asn Pro Arg Ser His Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 4020 4025 4030 tcg gac gag cgc ctc aag cag atc tac cag ttc gag tac gag ggc 21449 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly 4035 4040 4045 ctg ctg cgc cgc agc gcc ctg gcc acc gag gac cgc tgc gtc acc 21494 Leu Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr 4050 4055 4060 ctg gaa aag tcc acc cag acc gtg cag ggt ccg cgc tcg gcc gcc 21539 Leu Glu Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala 4065 4070 4075 tgc ggg ctc ttc tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg 21584 Cys Gly Leu Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp 4080 4085 4090 ccc gac cgc ccc atg gac aag aac ccc acc atg aac ttg ctg acg 21629 Pro Asp Arg Pro Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr 4095 4100 4105 ggg gtg ccc aac ggc atg ctc cag tcg ccc cag gtg gaa ccc acc 21674 Gly Val Pro Asn Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr 4110 4115 4120 ctg cgc cgc aac cag gag gcg ctc tac cgc ttc ctc aat gcc cac 21719 Leu Arg Arg Asn Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ala His 4125 4130 4135 tcc gcc tac ttt cgc tcc cac cgc gcg cgc atc gag aag gcc acc 21764 Ser Ala Tyr Phe Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr 4140 4145 4150 gcc ttc gac cgc atg aat caa gac atg taaaccgtgt gtatgtgaat 21811 Ala Phe Asp Arg Met Asn Gln Asp Met 4155 4160 gctttattca taataaacag cacatgttta tgccacctga ggctctgact ttatttagaa 21871 atcgaagggg ttctgccggc tctcggcatg gcccgcgggc agggatacgt tgcggaactg 21931 gtacttgggc agccacttga actcggggat cagcagcttc ggcacgggga ggtcggggaa 21991 cgagtcgctc cacagcttgc gcgtgagttg cagggcgccc agcaggtcgg gcgcggagat 22051 cttgaaatcg cagttgggac ccgcgttctg cgcgcgagag ttgcggtaca cggggttgca 22111 gcactggaac accattaggg ccgggtgctt cacgctcgcc agcaccgtcg cgtcggtgat 22171 gccctccacg tccagatcct cggcgttggc catcccgaag ggggtcatct tgcaggtctg 22231 ccgccccatg ctgggcacgc agccgggctt gtggttgcaa tcgcagtgca ggggaatcag 22291 catcatctgg gcctgctcgg agctcatgcc cgggtacatg gccttcatga aagcctccag 22351 ctggcggaag gcctgctgcg ccttgccgcc ctcggtgaag aagaccccgc aggacttgct 22411 agagaactgg ttggtggcgc agcccgcgtc gtgcacgcag cagcgcgcgt cgttgttggc 22471 cagctgcacc acgctgcgcc cccagcggtt ctgggtgatc ttggcccggt cggggttctc 22531 cttcagcgcg cgctgcccgt tctcgctcgc cacatccatc tcgatcgtgt gctccttctg 22591 gatcatcacg gtcccgtgca ggcaccgcag cttgccctcg gcctcggtgc atccgtgcag 22651 ccacagcgcg cagccggtgc tctcccagtt cttgtgggcg atctgggagt gcgagtgcac 22711 gaagccctgc aggaagcggc ccatcatcgt ggtcagggtc ttgttgctgg tgaaggtcag 22771 cgggatgccg cggtgctcct cgttcacata caggtggcag atgcggcggt acacctcgcc 22831 ctgctcgggc atcagctgga aggcggactt caggtcgctc tccacgcggt accgctccat 22891 cagcagcgtc atcacttcca tgcccttctc ccaggccgaa acgatcggca ggctcagggg 22951 gttcttcacc gttgtcatct tagtcgccgc cgccgaggtc agggggtcgt tctcgtccag 23011 ggtctcaaac actcgcttgc cgtccttctc ggtgatgcgc acggggggga aggcgaagcc 23071 cacggccgcc agctcctcct cggcctgcct ttcgtcctcg ctgtcctggc tgatgtcttg 23131 caaaggcaca tgcttggtct tgcggggttt ctttttgggc ggcagaggcg gcggcggaga 23191 cgtgctgggc gagcgcgagt tctcgctcac cacgactatt tcttctcctt ggccgtcgtc 23251 cgagaccacg cggcggtagg catgcctctt ctggggcaga ggcggaggcg acgggctctc 23311 gcggttcggc gggcggctgg cagagcccct tccgcgttcg ggggtgcgct cctggcggcg 23371 ctgctctgac tgacttcctc cgcggccggc cattatgttc tcctagggag caacaagc 23429 atg gag act cag cca tcg tcg cca aca tcg cca tct gcc ccc gcc 23474 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala 4165 4170 4175 gac gag aac cag cag cag aat gaa agc tta acc gcc ccg ccg ccc 23519 Asp Glu Asn Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro 4180 4185 4190 agc ccc acc tcc gac gcg gcc cca gac atg caa gag atg gag gaa 23564 Ser Pro Thr Ser Asp Ala Ala Pro Asp Met Gln Glu Met Glu Glu 4195 4200 4205 tcc atc gag att gac ctg ggc tac gtg acg ccc gcg gag cac gag 23609 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 4210 4215 4220 gag gag ctg gca gcg cgc ttt tca gcc ccg gaa gag aac cac caa 23654 Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 4225 4230 4235 gag cag cca gag cag gaa gca gag agc gag cag cag cag gct ggg 23699 Glu Gln Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly 4240 4245 4250 ctc gag cat ggc gac tac ctg agc ggg gca gag gac gtg ctc atc 23744 Leu Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile 4255 4260 4265 aag cat ctg gcc cgc caa tgc atc atc gtc aag gac gcg ctg ctc 23789 Lys His Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu 4270 4275 4280 gac cgc gcc gag gtg ccc ctc agc gtg gcg gag ctc agc cgc gcc 23834 Asp Arg Ala Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala 4285 4290 4295 tac gag cgc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc cag 23879 Tyr Glu Arg Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln 4300 4305 4310 ccc aac ggc acc tgc gag ccc aac ccg cgc ctt aac ttc tac ccg 23924 Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro 4315 4320 4325 gtc ttc gcg gtg ccc gag gcc ctg gcc acc tac cac atc ttt ttc 23969 Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr His Ile Phe Phe 4330 4335 4340 aag aac caa aag atc ccc gtc tcc tgc cgc gcc aac cgc acc cgc 24014 Lys Asn Gln Lys Ile Pro Val Ser Cys Arg Ala Asn Arg Thr Arg 4345 4350 4355 gcc gac gcc ctt ttc aac ctg ggc ccc ggc gcc cgc cta cct gat 24059 Ala Asp Ala Leu Phe Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp 4360 4365 4370 atc gcc tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg ggc 24104 Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu Gly 4375 4380 4385 agc gac gag act cgg gcc gcg aac gct ctg caa gga aat gaa gag 24149 Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Asn Glu Glu 4390 4395 4400 cat gag cac cac agc gcc ctg gtc gag ttg gaa ggc gac aac gcg 24194 His Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala 4405 4410 4415 cgc ctg gcg gtc ctc aag cgc acg gtc gag ctg acc cac ttc gcc 24239 Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala 4420 4425 4430 tac ccg gcg ctc aac ctg ccc ccc aag gtc atg aac gcc gtc atg 24284 Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Asn Ala Val Met 4435 4440 4445 gac cag gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag gag gag 24329 Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu 4450 4455 4460 atg cag gac ccc gag agc tcg gac gag ggc aag ccc gtg gtc agc 24374 Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser 4465 4470 4475 gac gag cag ctg gcg cgc tgg ctg gga gcg agt agc acc ccc cag 24419 Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 4480 4485 4490 agc ctg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg gtg 24464 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val 4495 4500 4505 acc gtg gag ctg gag tgt ctg cgc cgc ttc ttt gcc gac gcg gag 24509 Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu 4510 4515 4520 acc ctg cgc aag gtc gag gag aac ctg cac tac ctc ttc agg cac 24554 Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His 4525 4530 4535 ggg ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg acc 24599 Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr 4540 4545 4550 aac ctg gtc tcc tac atg ggc atc ctg cac gag aac cgc ctg ggg 24644 Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly 4555 4560 4565 caa aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc cgc gac 24689 Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp 4570 4575 4580 tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc tgg cag 24734 Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr Trp Gln 4585 4590 4595 acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag aac ctg 24779 Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn Leu 4600 4605 4610 aaa gag ctc tgc aag ctc ctg cag aag aac ctg aag gcc ctg tgg 24824 Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu Trp 4615 4620 4625 acc ggg ttc gac gag cgc acc acc gcc gcg gac ctg gcc gac ctc 24869 Thr Gly Phe Asp Glu Arg Thr Thr Ala Ala Asp Leu Ala Asp Leu 4630 4635 4640 atc ttc ccc gag cgc ctg cgg cta acg ctg cgc aac ggg ctg ccc 24914 Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro 4645 4650 4655 gac ttt atg agc caa agc atg ttg caa aac ttt cgc tct ttc atc 24959 Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile 4660 4665 4670 ctc gaa cgc tcc ggg atc ctg ccc gcc acc tgc tcc gca ctg ccc 25004 Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro 4675 4680 4685 tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg ccg ctc 25049 Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu 4690 4695 4700 tgg agc cac tgc tac ttg ctg cgc ctg gct aac tac ctg gcc tac 25094 Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr 4705 4710 4715 cac tcg gac gtg atc gag gac gtc agc ggc gag ggt ctg ctc gag 25139 His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 4720 4725 4730 tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc ctg gcc 25184 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala 4735 4740 4745 tgc aac ccc cag ctg ctg agc gag acc cag atc atc ggc acc ttc 25229 Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe 4750 4755 4760 gag ttg caa ggc ccc ggc gac agc gag ggc aag ggg ggt ctg aaa 25274 Glu Leu Gln Gly Pro Gly Asp Ser Glu Gly Lys Gly Gly Leu Lys 4765 4770 4775 ctc acc cct ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg 25319 Leu Thr Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val 4780 4785 4790 ccc gag gac tac cat ccc ttc gag atc agg ttc tac gag gac caa 25364 Pro Glu Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln 4795 4800 4805 tcc cag ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc acc cag 25409 Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln 4810 4815 4820 ggg gcc atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc caa 25454 Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln 4825 4830 4835 gaa ttt ctg ctg aaa aag ggc cac ggg gtc tac ctg gac ccc cag 25499 Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln 4840 4845 4850 acc gga gag gag ctc aac ccc agc ttc ccc cag gat gcc ccg agg 25544 Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Pro Arg 4855 4860 4865 aag cag caa gaa gct gaa agt gga gct gcc gcc gga gga ttt gga 25589 Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Gly Gly Phe Gly 4870 4875 4880 gga aga ctg gga gag cag tca ggc aga gga gga gat gga aga ctg 25634 Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Asp Gly Arg Leu 4885 4890 4895 gga cag cac tca ggc aga gga gga cag cct gca aga cag tct gga 25679 Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly 4900 4905 4910 gga gga aga cga ggt gga gga gga ggc aga gga aga agc agc cgc 25724 Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg 4915 4920 4925 cgc cag acc gtc gtc ctc ggc gga gga gaa agc aag cag cac gga 25769 Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys Gln His Gly 4930 4935 4940 tac cat ctc cgc tcc ggg tcg ggg tcg cgg cgg tcg ggc cca cag 25814 Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Ser Gly Pro Gln 4945 4950 4955 tagatgggac gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg 25874 gcagggatac aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg 25934 cgggggcaac atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc 25994 ccgcaacatc ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga 26054 ggcagaaacc cagcagcagc agaaaaccag cggcagcagc agcagcagct agaaaatcca 26114 cagcggcggc ggcggcaggt ggactgagga tcgcggcgaa cgagccggcg cagacccggg 26174 agctgaggaa ccggatcttt cccaccctct atgccatctt ccagcagagt cgggggcagg 26234 agcaggaact gaaagtcaag aaccgttctc tgcgctcgct cacccgcagt tgtctgtatc 26294 acaagagcga agaccaactt cagcgcactc tcgaggacgc cgaggctctc ttcaacaagt 26354 actgcgcgct cactcttaaa gagtagcccg cgcccgccca cacacggaaa aaggcgggaa 26414 ttacgtcacc acctgcgccc ttcgcccgac catcatc atg agc aaa gag att ccc 26469 Met Ser Lys Glu Ile Pro 4960 acg cct tac atg tgg agc tac cag ccc cag atg ggc ctg gcc gcc 26514 Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala 4965 4970 4975 ggc gcc gcc cag gac tac tcc acc cgc atg aac tgg ctc agt gcc 26559 Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala 4980 4985 4990 ggg ccc gcg atg atc tca cgg gtg aat gac atc cgc gcc cac cga 26604 Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg Ala His Arg 4995 5000 5005 aac cag ata ctc cta gaa cag tca gcg atc acc gcc acg ccc cgc 26649 Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg 5010 5015 5020 cat cac ctt aat ccg cgt aat tgg ccc gcc gcc ctg gtg tac cag 26694 His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln 5025 5030 5035 gaa att ccc cag ccc acg acc gta cta ctt ccg cga gac gcc cag 26739 Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 5040 5045 5050 gcc gaa gtc cag ctg act aac tca ggt gtc cag ctg gcc ggc ggc 26784 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly 5055 5060 5065 gcc gcc ctg tgt cgt cac cgc ccc gct cag ggt ata aag cgg ctg 26829 Ala Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu 5070 5075 5080 gtg atc cga ggc aga ggc aca cag ctc aac gac gag gtg gtg agc 26874 Val Ile Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser 5085 5090 5095 tct tcg ctg ggt ctg cga cct gac gga gtc ttc caa ctc gcc gga 26919 Ser Ser Leu Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly 5100 5105 5110 tcg ggg aga tct tcc ttc acg cct cgt cag gcc gtc ctg act ttg 26964 Ser Gly Arg Ser Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu 5115 5120 5125 gag agt tcg tcc tcg cag ccc cgc tcg ggc ggc atc ggc act ctc 27009 Glu Ser Ser Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu 5130 5135 5140 cag ttc gtg gag gag ttc act ccc tcg gtc tac ttc aac ccc ttc 27054 Gln Phe Val Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe 5145 5150 5155 tcc ggc tcc ccc ggc cac tac ccg gac gag ttc atc ccg aac ttc 27099 Ser Gly Ser Pro Gly His Tyr Pro Asp Glu Phe Ile Pro Asn Phe 5160 5165 5170 gac gcc atc agc gag tcg gtg gac ggc tac gat tga atg tcc cat 27144 Asp Ala Ile Ser Glu Ser Val Asp Gly Tyr Asp Met Ser His 5175 5180 5185 ggt ggc gcg gct gac cta gct cgg ctt cga cac ctg gac cac tgc 27189 Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp His Cys 5190 5195 5200 cgc cgc ttc cgc tgc ttc gct cgg gat ctc gcc gag ttt gcc tac 27234 Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr 5205 5210 5215 ttt gag ctg ccc gag gag cac cct cag ggc ccg gcc cac gga gtg 27279 Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 5220 5225 5230 cgg atc gtc gtc gaa ggg ggc ctc gac tcc cac ctg ctt cgg atc 27324 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile 5235 5240 5245 ttc agc cag cga ccg atc ctg gtc gag cgc gag caa gga cag acc 27369 Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr 5250 5255 5260 cgt ctg acc ctg tac tgc atc tgc aac cac ccc ggc ctg cat gaa 27414 Arg Leu Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu 5265 5270 5275 agt ctt tgt tgt ctg ctg tgt act gag tat aat aaa agc tgagatcagc 27463 Ser Leu Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5280 5285 gactactccg gactcgattg tggtgttcct gctatcaacc ggtccctgtt cttcaccggg 27523 aacgagaccg agctccagct ccagtgtaag ccccacaaga agtatctcac ctggctgttc 27583 cagggctccc cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc 27643 cccgccaacc ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc 27703 cccgggacct atcagtgcct ctcgggaccc tgccatcaca ccttccacct gatcccgaat 27763 accacagcgg cgctccccgc tactaacaac caaactaccc accaacgcca ccgtcgcgac 27823 ctttcctctg aatctaatac taccacccac accggaggtg agctccgagg tcaaccaacc 27883 tctgggattt actacggccc ctgggaggtg gtggggttaa tagcgctagg cctagttgcg 27943 ggtgggcttt tggctctctg ctacctatac ctcccttgct gttcttactt agtggtgctg 28003 tgttgctggt ttaagaaatg gggaagatca ccctagtgag ctgcggtgcg ctggtggcgg 28063 tggtgctttc gattgtggga ctgggcggcg cggctgtagt gaaggagaag gccgatccct 28123 gcttgcattt caatcccgac aaatgccagc tgagttttca gcccgatggc aatcggtgcg 28183 cggtgctgat caagtgcgga tgggaatgcg agaacgtgag aatcgagtac aataacaaga 28243 ctcggaacaa tactctcgcg tccgtgtggc agcccgggga ccccgagtgg tacaccgtct 28303 ctgtccccgg tgctgacggc tccccgcgca ccgtgaacaa tactttcatt tttgcacaca 28363 tgtgcgacac ggtcatgtgg atgagcaagc agtacgatat gtggcccccc acgaaggaga 28423 acatcgtggt cttctccatc gcttacagcc tgtgcacggc gctaatcacc gctatcgtgt 28483 gcctgagcat tcacatgctc atcgctattc gccccagaaa taatgccgaa aaagagaaac 28543 agccataaca cgttttttca cacacctttt tcagacc atg gcc tct gtt aaa ttt 28598 Met Ala Ser Val Lys Phe 5290 ttt gct tta ttt gcc agt ctc att acc gtc att cat gga atg agt 28643 Phe Ala Leu Phe Ala Ser Leu Ile Thr Val Ile His Gly Met Ser 5295 5300 5305 aat gag aaa att act att tac act ggc act aat cac aca ttg aaa 28688 Asn Glu Lys Ile Thr Ile Tyr Thr Gly Thr Asn His Thr Leu Lys 5310 5315 5320 ggt cca gaa aaa gcc aca gaa gtt tca tgg tat tgt tat ttt aat 28733 Gly Pro Glu Lys Ala Thr Glu Val Ser Trp Tyr Cys Tyr Phe Asn 5325 5330 5335 gaa tca gat gta gct act gaa ctc tgt gga aac aac aac aaa aaa 28778 Glu Ser Asp Val Ala Thr Glu Leu Cys Gly Asn Asn Asn Lys Lys 5340 5345 5350 aat gag agc att act ctc atc aag ttt caa tgt gga tct gac tta 28823 Asn Glu Ser Ile Thr Leu Ile Lys Phe Gln Cys Gly Ser Asp Leu 5355 5360 5365 acc ctc att aac atc act aga gac tat gta ggt atg tat tat gga 28868 Thr Leu Ile Asn Ile Thr Arg Asp Tyr Val Gly Met Tyr Tyr Gly 5370 5375 5380 act aca gca ggc att tcg gac atg gaa ttt tat caa gtt tct gtg 28913 Thr Thr Ala Gly Ile Ser Asp Met Glu Phe Tyr Gln Val Ser Val 5385 5390 5395 tct gaa ccc acc acg cct aga atg acc aca acc aca aaa act aca 28958 Ser Glu Pro Thr Thr Pro Arg Met Thr Thr Thr Thr Lys Thr Thr 5400 5405 5410 cct act acc acc aca cag ctc act acc aat ggc ttt ttt gcc atg 29003 Pro Thr Thr Thr Thr Gln Leu Thr Thr Asn Gly Phe Phe Ala Met 5415 5420 5425 ctt caa gtg gct gaa aat agc acc agc att caa ccc acc cca ccc 29048 Leu Gln Val Ala Glu Asn Ser Thr Ser Ile Gln Pro Thr Pro Pro 5430 5435 5440 agt gag gaa att ccc aaa tcc atg att ggc att att gtt gct gta 29093 Ser Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val 5445 5450 5455 gtg gtg tgc atg ttg atc atc gcc ttg tgc atg gtg tac tat gcc 29138 Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala 5460 5465 5470 ttc tgc tac aga aag cac aga ctg aac gac aag ctg gaa cac tta 29183 Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu 5475 5480 5485 cta agt gtt gaa ttt taatttttta gaacc atg aag atc cta tgc ctt 29231 Leu Ser Val Glu Phe Met Lys Ile Leu Cys Leu 5490 5495 5500 tta gtt ttt tat atc att acc tct gct ctt tgt gaa tca gtg gat 29276 Leu Val Phe Tyr Ile Ile Thr Ser Ala Leu Cys Glu Ser Val Asp 5505 5510 5515 aaa gat gtt act att acc act ggt tct aat tat aca ctg aaa gga 29321 Lys Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly 5520 5525 5530 cca ccc tca ggt atg ctt tcg tgg tat tgc tat ttt gga act gac 29366 Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe Gly Thr Asp 5535 5540 5545 act gat caa act gaa tta tgc aat ttt caa aaa ggc aaa acc tca 29411 Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys Thr Ser 5550 5555 5560 aac tct aaa atc tct aat tat caa tgc aat ggc act gat ctg ata 29456 Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu Ile 5565 5570 5575 cta ctc aat gtc acg aaa gca tat ggt ggc agt tat tca tgc cct 29501 Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Ser Cys Pro 5580 5585 5590 gga caa aac act gaa gaa atg att ttt tac aaa gtg gaa gtg gtt 29546 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val 5595 5600 5605 gat ccc act act cca cct cca ccc gcc aca act act cac acc aca 29591 Asp Pro Thr Thr Pro Pro Pro Pro Ala Thr Thr Thr His Thr Thr 5610 5615 5620 cac aca gaa caa agc aca gca gag gca gca aag tta gcc ttg cag 29636 His Thr Glu Gln Ser Thr Ala Glu Ala Ala Lys Leu Ala Leu Gln 5625 5630 5635 gtc caa gac agt tca ttt gtt ggc att acc cct aca cct gat cag 29681 Val Gln Asp Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln 5640 5645 5650 cgg tgt ccg ggg ctg ctc gtc agc ggc att gtc ggt gtg ctt tcg 29726 Arg Cys Pro Gly Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser 5655 5660 5665 gga tta gca gtc ata atc atc tgc atg ttc att ttt gct tgc tgc 29771 Gly Leu Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys 5670 5675 5680 tat aga agg ctt tac cga caa aaa tca gac cca ctg ctg aac ctc 29816 Tyr Arg Arg Leu Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu 5685 5690 5695 tat gtt taattttttc cagagcc atg aag gca gtt agc gct cta gtt ttt 29866 Tyr Val Met Lys Ala Val Ser Ala Leu Val Phe 5700 5705 tgt tct ttg att ggc att gtt ttt aat agt aaa att acc aga gtt 29911 Cys Ser Leu Ile Gly Ile Val Phe Asn Ser Lys Ile Thr Arg Val 5710 5715 5720 agc ttt att aaa cat gtt aat gta act gaa gga gat aac atc aca 29956 Ser Phe Ile Lys His Val Asn Val Thr Glu Gly Asp Asn Ile Thr 5725 5730 5735 cta gca ggt gta gaa ggt gct caa aac acc acc tgg aca aaa tac 30001 Leu Ala Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr 5740 5745 5750 cat cta gga tgg aga gat att tgc acc tgg aat gta act tat tat 30046 His Leu Gly Trp Arg Asp Ile Cys Thr Trp Asn Val Thr Tyr Tyr 5755 5760 5765 tgc ata gga gtt aat ctt acc att gtt aac gct aac caa tct cag 30091 Cys Ile Gly Val Asn Leu Thr Ile Val Asn Ala Asn Gln Ser Gln 5770 5775 5780 aat ggg tta att aaa gga cag agt gtt agt gtg acc agt gat ggg 30136 Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr Ser Asp Gly 5785 5790 5795 tac tat acc cag cat agt ttt aac tac aac att act gtc ata cca 30181 Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val Ile Pro 5800 5805 5810 ctg cct acg cct agc cca cct agc act acc gca cag aca acc aca 30226 Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Ala Gln Thr Thr Thr 5815 5820 5825 tac agt aca tca aat cag cct acc acc act aca gca gca gag gtt 30271 Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 5830 5835 5840 gcc agc tcg tct ggg gtc cga gtg gca ttt ttg atg ttg gcc cca 30316 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro 5845 5850 5855 tct agc agt ccc act gct agt acc aat gag cag act act gaa ttt 30361 Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe 5860 5865 5870 ttg tcc act gtc gag agc cac acc aca gct acc tcc agt gcc ttc 30406 Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe 5875 5880 5885 tct agc acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc agt 30451 Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser 5890 5895 5900 ccc gct act act cct agc ccc gct cct ctt ccc act ccc ctg aag 30496 Pro Ala Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 5905 5910 5915 caa aca gac ggc ggc atg caa tgg cag atc acc ctg ctc att gtg 30541 Gln Thr Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val 5920 5925 5930 atc ggg ttg gtc atc ctg gcc gtg ttg cta tac tac atc ttc tgc 30586 Ile Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys 5935 5940 5945 cgc cgc att ccc aac gcg cac cgc aag ccg gcc tac aag ccc atc 30631 Arg Arg Ile Pro Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile 5950 5955 5960 gtt atc ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg 30676 Val Ile Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg 5965 5970 5975 aat ctt ctc ttc tct ttt aca gta tgg tgattgaact atg att cct aga 30725 Asn Leu Leu Phe Ser Phe Thr Val Trp Met Ile Pro Arg 5980 5985 caa ttc ttg atc act att ctt atc tgc ctc ctc caa gtc tgt gcc 30770 Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln Val Cys Ala 5990 5995 6000 acc ctc gct ctg gtg gcc aac gcc agt cca gac tgt att gga ccc 30815 Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile Gly Pro 6005 6010 6015 ttc gcc tcc tac gtg ctc ttt gcc ttc gtc acc tgc atc tgc tgc 30860 Phe Ala Ser Tyr Val Leu Phe Ala Phe Val Thr Cys Ile Cys Cys 6020 6025 6030 tgt agc ata gtc tgc ctg ctt atc acc ttc ttc cag ttc att gac 30905 Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 6035 6040 6045 tgg atc ttt gtg cgc atc gcc tac ctg cgc cac cac ccc cag tac 30950 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr 6050 6055 6060 cgc gac cag cga gtg gcg cag ctg ctc agg ctc ctc tgataagcat 30996 Arg Asp Gln Arg Val Ala Gln Leu Leu Arg Leu Leu 6065 6070 6075 gcgggctctg ctacttctcg cgcttctgct gttagtgctc ccccgtcccg ttgacccccg 31056 gccccccact cagtcccccg aggaggtccg caaatgcaaa ttccaagaac cctggaaatt 31116 cctcaaatgc taccgccaaa aatcagacat gcatcccagc tggatcatga tcattgggat 31176 cgtgaacatt ctggcctgca ccctcatctc ctttgtgatt tacccctgct ttgactttgg 31236 ttggaactcg ccagaggcgc tctatctccc gcctgaacct gacacaccac cacagcaacc 31296 tcaggcacac gcactaccac caccacagcc taggccacaa tacatgccca tattagacta 31356 tgaggccgag ccacagcgac ccatgctccc cgctattagt tacttcaatc taaccggcgg 31416 ag atg act gac cca ctg gcc aac aac aac gtc aac gac ctt ctc ctg 31463 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu 6080 6085 6090 gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa ctt cgc 31508 Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg 6095 6100 6105 att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac ggc 31553 Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly 6110 6115 6120 ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa 31598 Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys 6125 6130 6135 cag gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc ctc 31643 Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu 6140 6145 6150 tcc tac gag ctc ctg cag cag cgc cag aag ttc acc tgc ctg gtc 31688 Ser Tyr Glu Leu Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu Val 6155 6160 6165 gga gtc aac ccc atc gtc atc acc cag cag tcg ggc gat acc aag 31733 Gly Val Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys 6170 6175 6180 ggg tgc atc cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act 31778 Gly Cys Ile His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr 6185 6190 6195 ctg atc aag acc ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac 31823 Leu Ile Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 6200 6205 6210 taatcaccca cttatccagt gaaataaaaa aataatcatt tgatttgaaa taaagataca 31883 atcatattga tgatttgagt ttaacaaaaa taaagaatca cttacttgaa atctgatacc 31943 aggtctctgt ccatattttc tgccaacacc acctcactcc cctcttccca gctctggtac 32003 tgcaggcccc ggcgggctgc aaacttcctc cacacgctga aggggatgtc aaattcctcc 32063 tgcccctcaa tcttcatttt atcttctatc ag atg tcc aaa aag cgc gtc cgg 32116 Met Ser Lys Lys Arg Val Arg 6215 gtg gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac aac 32161 Val Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn 6220 6225 6230 gca ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca gat 32206 Ala Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp 6235 6240 6245 gga ttc caa gag aag ccc ctg ggg gtg ttg tcc ctg cga ctg gcc 32251 Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala 6250 6255 6260 gac ccc gtc acc acc aag aac ggg gaa atc acc ctc aag ctg gga 32296 Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu Lys Leu Gly 6265 6270 6275 gag ggg gtg gac ctc gac tcc tcg gga aaa ctc atc tcc aac acg 32341 Glu Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser Asn Thr 6280 6285 6290 gcc gcc aag gcc gct gcc cct ctc agt ttt tcc aac aac acc att 32386 Ala Ala Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr Ile 6295 6300 6305 tcc ctt aac atg gat cac ccc ttt tac act aaa gat gga aaa tta 32431 Ser Leu Asn Met Asp His Pro Phe Tyr Thr Lys Asp Gly Lys Leu 6310 6315 6320 gcc tta caa gtt tct cca cca tta aat ata ctg aga aca agc att 32476 Ala Leu Gln Val Ser Pro Pro Leu Asn Ile Leu Arg Thr Ser Ile 6325 6330 6335 cta aac aca cta gct tta ggt ttt gga tca ggt tta gga ctc cgt 32521 Leu Asn Thr Leu Ala Leu Gly Phe Gly Ser Gly Leu Gly Leu Arg 6340 6345 6350 ggc tct gcc ttg gca gta cag tta gtc tct cca ctt aca ttt gat 32566 Gly Ser Ala Leu Ala Val Gln Leu Val Ser Pro Leu Thr Phe Asp 6355 6360 6365 act gat gga aac ata aag ctt acc tta gac aga ggt ttg cat gtt 32611 Thr Asp Gly Asn Ile Lys Leu Thr Leu Asp Arg Gly Leu His Val 6370 6375 6380 aca aca gga gat gca att gaa agc aac ata agc tgg gct aaa ggt 32656 Thr Thr Gly Asp Ala Ile Glu Ser Asn Ile Ser Trp Ala Lys Gly 6385 6390 6395 tta aaa ttt gaa gat gga gcc ata gca acc aac att gga aat ggg 32701 Leu Lys Phe Glu Asp Gly Ala Ile Ala Thr Asn Ile Gly Asn Gly 6400 6405 6410 tta gag ttt gga agc agt agt aca gaa aca ggt gtc gat gat gct 32746 Leu Glu Phe Gly Ser Ser Ser Thr Glu Thr Gly Val Asp Asp Ala 6415 6420 6425 tac cca atc caa gtt aaa ctt gga tct ggc ctt agc ttt gac agt 32791 Tyr Pro Ile Gln Val Lys Leu Gly Ser Gly Leu Ser Phe Asp Ser 6430 6435 6440 aca gga gcc ata atg gct ggt aac aaa gaa gac gat aaa ctc act 32836 Thr Gly Ala Ile Met Ala Gly Asn Lys Glu Asp Asp Lys Leu Thr 6445 6450 6455 ttg tgg aca aca cct gat cca tca cca aac tgt caa ata ctc gca 32881 Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Ile Leu Ala 6460 6465 6470 gaa aat gat gca aaa cta aca ctt tgc ttg act aaa tgt ggt agt 32926 Glu Asn Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser 6475 6480 6485 caa ata ctg gcc act gtg tca gtc tta gtt gta gga agt gga aac 32971 Gln Ile Leu Ala Thr Val Ser Val Leu Val Val Gly Ser Gly Asn 6490 6495 6500 cta aac ccc att act ggc acc gta agc agt gct cag gtg ttt cta 33016 Leu Asn Pro Ile Thr Gly Thr Val Ser Ser Ala Gln Val Phe Leu 6505 6510 6515 cgt ttt gat gca aac ggt gtt ctt tta aca gaa cat tct aca cta 33061 Arg Phe Asp Ala Asn Gly Val Leu Leu Thr Glu His Ser Thr Leu 6520 6525 6530 aaa aaa tac tgg ggg tat agg cag gga gat agc ata gat ggc act 33106 Lys Lys Tyr Trp Gly Tyr Arg Gln Gly Asp Ser Ile Asp Gly Thr 6535 6540 6545 cca tat gcc aat gct gta gga ttc atg ccc aat tta aaa gct tat 33151 Pro Tyr Ala Asn Ala Val Gly Phe Met Pro Asn Leu Lys Ala Tyr 6550 6555 6560 cca aag tca caa agt tct act act aaa aat aat ata gta ggg caa 33196 Pro Lys Ser Gln Ser Ser Thr Thr Lys Asn Asn Ile Val Gly Gln 6565 6570 6575 gta tac atg aat gga gat gtt tca aaa cct atg ctt ctc act ata 33241 Val Tyr Met Asn Gly Asp Val Ser Lys Pro Met Leu Leu Thr Ile 6580 6585 6590 acc ctc aat ggt act gat gac agc aac agt aca tat tca atg tca 33286 Thr Leu Asn Gly Thr Asp Asp Ser Asn Ser Thr Tyr Ser Met Ser 6595 6600 6605 ttt tca tac acc tgg act aat gga agc tat gtt gga gca aca ttt 33331 Phe Ser Tyr Thr Trp Thr Asn Gly Ser Tyr Val Gly Ala Thr Phe 6610 6615 6620 gga gct aac tct tat acc ttc tcc tac atc gcc caa gaa tgaatactgt 33380 Gly Ala Asn Ser Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 6625 6630 6635 atcccaccct gcatgcccaa ccctccccca cctctgtcta tatggaaaac tctgaaacac 33440 aaaataaaat aaagttcaag tgttttattg attcaacagt tttacaggat tcgagcagtt 33500 atttttcctc caccctccca ggacatggaa tacaccaccc tctccccccg cacagccttg 33560 aacatctgaa tgccattggt gatggacatg cttttggtct ccacgttcca cacagtttca 33620 gagcgagcca gtctcgggtc ggtcagggag atgaaaccct ccgggcactc ccgcatctgc 33680 acctcacagc tcaacagctg aggattgtcc tcggtggtcg ggatcacggt tatctggaag 33740 aagcagaaga gcggcggtgg gaatcatagt ccgcgaacgg gatcggccgg tggtgtcgca 33800 tcaggccccg cagcagtcgc tgccgccgcc gctccgtcaa gctgctgctc agggggtccg 33860 ggtccaggga ctccctcagc atgatgccca cggccctcag catcagtcgt ctggtgcggc 33920 gggcgcagca gcgcatgcgg atctcgctca cgtcgctgca gtacgtgcaa cacaggacca 33980 ccaggttgtt caacagtcca tagttcaaca cgctccagcc gaaactcatc gcgggaagga 34040 tgctacccac gtggccgtcg taccagatcc tcaggtaaat caagtggcgc cccctccaga 34100 acacgctgcc catgtacatg atctccttgg gcatgtggcg gttcaccacc tcccggtacc 34160 acatcaccct ctggttgaac atgcagcccc ggatgatcct gcggaaccac agggccagca 34220 ccgccccgcc cgccatgcag cgaagagacc ccgggtcccg gcaatggcaa tggaggaccc 34280 accgctcgta cccgtggatc atctgggagc tgaacaagtc tatgttggca cagcacaggc 34340 acacgctcat gcatctcttc agcactctca gctcctcggg ggtcaaaacc atatcccagg 34400 gcacgggaaa ctcttgcagg acagcgaagc ccgcagaaca gggcaatcct cgcacataac 34460 ttacattgtg catggacagg gtatcgcaat caggcagcac cgggtgatcc tccaccagag 34520 aagcgcgggt ctcggtctcc tcacagcgtg gtaagggggc cggccgatac gggtgatggc 34580 gggacgcggc tgatcgtgtt cgcgaccgtg tcatgatgca gttgctttcg gacattttcg 34640 tacttgctga agcagaacct ggtccgggcg ctgcacaccg atcgccggcg gcggtctcgg 34700 cgcttggaac gctcggtgtt gaagttgtaa aacagccact ctctcagacc gtgcagcaga 34760 tctagggcct caggagtgat gaagatccca tcatgcctga tggctctgat cacatcgacc 34820 accgtggaat gggccagacc cagccagatg atgcaatttt gttgggtttc ggtgacggcg 34880 ggggagggaa gaacaggaag aaccatgatt aacttttaat ccaaacggtc tcggagcact 34940 tcaaaatgaa ggtcgcggag atggcacctc tcgcccccgc tgtgttggtg gaaaataaca 35000 gccaggtcaa aggtgatacg gttctcgaga tgttccacgg tggcttccag caaagcctcc 35060 acgcgcacat ccagaaacaa gacaatagcg aaagcgggag ggttctctaa ttcctcaatc 35120 atcatgttac actcctgcac catccccaga taattttcat ttttccagcc ttgaatgatt 35180 cgaactagtt cctgaggtaa atccaagcca gccatgataa agagctcgcg cagagcgccc 35240 tccaccggca ttcttaagca caccctcata attccaagat attctgctcc tggttcacct 35300 gcagcagatt gacaagcggg atatcaaaat ctctgccgcg atccctgagc tcctccctca 35360 gcaataactg taagtactct ttcatatcct ctccgaaatt tttagccata ggacccccag 35420 gaataagaga agggcaagcc acattacaga taaaccgaag tcccccccag tgagcattgc 35480 caaatgtaag attgaaataa gcatgctggc tagacccggt gatatcttcc agataactgg 35540 acagaaaatc gggcaagcaa tttttaagaa aatcaacaaa agaaaaatct tccaggtgca 35600 cgtttagggc ctcgggaaca acgatggagt aagtgcaagg ggtgcgttcc agcatggtta 35660 gttagctgat ctgtaaaaaa acaaaaaata aaacattaaa ccatgctagc ctggcgaaca 35720 ggtgggtaaa tcgttctctc cagcaccagg caggccacgg ggtctccggc gcgaccctcg 35780 taaaaattgt cgctatgatt gaaaaccatc acagagagac gttcccggtg gccggcgtga 35840 atgattcgag aagaagcata cacccccgga acattggagt ccgtgagtga aaaaaagcgg 35900 ccgaggaagc aatgaggcac tacaacgctc actctcaagt ccagcaaagc gatgccatgc 35960 ggatgaagca caaaattttc aggtgcgtaa aaaatgtaat tactcccctc ctgcacaggc 36020 agcgaagctc ccgatccctc cagatacaca tacaaagcct cagcgtccat agcttaccga 36080 gcggcagcag cagcggcaca caacaggcgc aagagtcaga gaaaagactg agctctaacc 36140 tgtccgcccg ctctctgctc aatatatagc cccagatcta cactgacgta aaggccaaag 36200 tctaaaaata cccgccaaat aatcacacac gcccagcaca cgcccagaaa ccggtgacac 36260 actcaaaaaa atacgcgcac ttcctcaaac gcccaaactg ccgtcatttc cgggttccca 36320 cgctacgtca tcaaaacacg actttcaaat tccgtcgacc gttaaaaacg tcacccgccc 36380 cgcccctaac ggtcgccgct cccgcagcca atcaccgccc cgcatcccca aattcaaata 36440 cctcatttgc atattaacgc gcaccaaaag tttaaggtat attatttgat gatg 36494 <210> 66 <211> 504 <212> PRT <213> Simian adenovirus 38 <400> 66 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg 65 70 75 80 Ser Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro 85 90 95 Glu Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly 100 105 110 Ile Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr 115 120 125 Val Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu 130 135 140 Val Gln Ser Gln Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr 145 150 155 160 Ser Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp 165 170 175 Glu Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys 180 185 190 Lys Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile 195 200 205 Ser Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Ala Ala 210 215 220 Phe Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu 225 230 235 240 Gly Val Thr Phe Met Asn Thr Arg Phe Arg Gly Asp Gly Tyr Asn Gly 245 250 255 Val Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe 260 265 270 Phe Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val 275 280 285 Arg Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr 290 295 300 Lys Ser Val Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu 305 310 315 320 Gly Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr 325 330 335 Glu Thr Gly Cys Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His 340 345 350 Asn Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr 355 360 365 Cys Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser 370 375 380 His Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg 385 390 395 400 Cys Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln 405 410 415 Cys Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser 420 425 430 Arg Val Ser Leu Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys 435 440 445 Ile Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys 450 455 460 Gly Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu 465 470 475 480 Asp Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe 485 490 495 Gly Ser Ser Gly Glu Glu Ser Asp 500 <210> 67 <211> 142 <212> PRT <213> Simian adenovirus 38 <400> 67 Met Ser Gly Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu 1 5 10 15 Thr Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly 20 25 30 Ser Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu 35 40 45 Thr Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala 50 55 60 Ala Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala 65 70 75 80 Gly Tyr Tyr Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro 85 90 95 Ala Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu 100 105 110 Ala Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu 115 120 125 Gln Ala Glu Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 130 135 140 <210> 68 <211> 392 <212> PRT <213> Simian adenovirus 38 <400> 68 Met His Pro Val Leu Arg Gln Met Arg Pro His Pro Pro Pro Gln Pro 1 5 10 15 Pro Leu Pro Gln Gln Gln Gln Gln Pro Ala Leu Leu Pro Pro Pro Gln 20 25 30 Gln Gln Gln Gln Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala 35 40 45 Gly Val Gln Tyr Asp Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg 50 55 60 Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg 65 70 75 80 Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg 85 90 95 Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ser Arg Phe His Ala Gly 100 105 110 Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu 115 120 125 Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His 130 135 140 Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu 145 150 155 160 Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile 165 170 175 Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu 180 185 190 Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu 195 200 205 Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala 210 215 220 Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val 225 230 235 240 Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser 245 250 255 Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr 260 265 270 Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu 275 280 285 Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr 290 295 300 Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala 305 310 315 320 Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His 325 330 335 Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr 340 345 350 Phe Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu 355 360 365 Glu Ala Ala Gly Gly Val Pro Tyr Val Glu Glu Val Asp Asp Glu Glu 370 375 380 Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 69 <211> 586 <212> PRT <213> Simian adenovirus 38 <400> 69 Met Gln Gln Gln Pro Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu 1 5 10 15 Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala 20 25 30 Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 35 40 45 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val 50 55 60 Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn 65 70 75 80 Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val 85 90 95 Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val 100 105 110 Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ser 115 120 125 Gln Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala 130 135 140 Leu Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln 145 150 155 160 Glu Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Ala Glu 165 170 175 Val Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln 180 185 190 Thr Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys 195 200 205 Asn Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala 210 215 220 Thr Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 225 230 235 240 Val Ala Pro Phe Thr Asp Ser Gly Ser Val Ser Arg Asp Ser Tyr Leu 245 250 255 Gly Tyr Leu Leu Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val 260 265 270 Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 275 280 285 Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr 290 295 300 Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu 305 310 315 320 Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met 325 330 335 Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn 340 345 350 Met Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu 355 360 365 Met Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr 370 375 380 Asn Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr 385 390 395 400 Gly Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp 405 410 415 Val Asp Ser Ser Val Phe Ser Pro Arg Pro Thr Thr Thr Val Trp Lys 420 425 430 Lys Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala 435 440 445 Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu 450 455 460 Pro Phe Ser Leu Asn Ser Val Arg Ser Ser Glu Leu Gly Arg Leu Thr 465 470 475 480 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu 485 490 495 Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu 500 505 510 Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp 515 520 525 Glu Pro Arg Ala Ser Ser Ser Thr Gly Ala Arg Arg Arg Gln Arg His 530 535 540 Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp 545 550 555 560 Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala 565 570 575 His Leu Arg Pro Arg Ile Gly Arg Leu Met 580 585 <210> 70 <211> 539 <212> PRT <213> Simian adenovirus 38 <400> 70 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln Asp Glu 145 150 155 160 Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser 165 170 175 Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr 180 185 190 Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val 195 200 205 Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 210 215 220 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile 225 230 235 240 Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser 245 250 255 Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln 260 265 270 Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 275 280 285 Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala Ala Ala Thr 290 295 300 Ala Ala Val Ala Thr Ala Ala Thr Thr Asp Ala Asp Ala Ala Thr Thr 305 310 315 320 Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu Glu Ala Ala Ala Leu 325 330 335 Ala Ala Thr Asp Asp Ser Glu Ser Lys Ile Val Ile Lys Pro Val Glu 340 345 350 Lys Asp Ser Lys Asp Arg Ser Tyr Asn Val Leu Ser Asp Gly Lys Asn 355 360 365 Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu 370 375 380 Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys 385 390 395 400 Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro 405 410 415 Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly 420 425 430 Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala 435 440 445 Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe 450 455 460 Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr 465 470 475 480 Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr 485 490 495 Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr 500 505 510 Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val 515 520 525 Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe 530 535 <210> 71 <211> 194 <212> PRT <213> Simian adenovirus 38 <400> 71 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Ala Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 72 <211> 349 <212> PRT <213> Simian adenovirus 38 <400> 72 Met Ser Lys Arg Lys Tyr Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Val Asn 35 40 45 Gly Leu Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln 50 55 60 Trp Arg Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val 65 70 75 80 Val Phe Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr 85 90 95 Asp Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Val Glu Arg 100 105 110 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys 115 120 125 Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser 130 135 140 Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Gly Ala Ala Pro Arg 145 150 155 160 Arg Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln 165 170 175 Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met 180 185 190 Lys Val Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys 195 200 205 Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro 210 215 220 Thr Glu Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser 225 230 235 240 Thr Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Pro Ala Ser Thr 245 250 255 Thr Thr Thr Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 260 265 270 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg 275 280 285 Gly Thr Arg Phe Tyr Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr 290 295 300 Thr Thr Arg Arg Arg Arg Arg Ser Arg Arg Ser Ser Thr Ala Thr Ser 305 310 315 320 Ala Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu 325 330 335 Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 73 <211> 77 <212> PRT <213> Simian adenovirus 38 <400> 73 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 74 <211> 240 <212> PRT <213> Simian adenovirus 38 <400> 74 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Val Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Ser Ser Ser Ser Gln Pro Ala Thr Leu Asp Leu Pro Pro Pro 180 185 190 Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala Ser 195 200 205 Arg Ala Pro Arg Gly Arg Pro Gln Ala Asn Trp Gln Ser Thr Leu Asn 210 215 220 Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 225 230 235 240 <210> 75 <211> 930 <212> PRT <213> Simian adenovirus 38 <400> 75 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Thr Asp Asn Gln Thr Glu Lys 130 135 140 Thr Ala Thr Tyr Gly Asn Ala Pro Val Glu Gly Ile Asn Ile Thr Lys 145 150 155 160 Asp Gly Ile Gln Leu Gly Thr Asp Ser Asp Gly Gln Ala Ile Tyr Ala 165 170 175 Asp Glu Thr Tyr Gln Pro Glu Pro Gln Val Gly Asp Pro Glu Trp His 180 185 190 Asp Thr Thr Gly Thr Glu Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro 195 200 205 Ala Thr Asp Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn 210 215 220 Val Lys Gly Gly Gln Ala Lys Ser Arg Thr Lys Thr Asp Gly Thr Thr 225 230 235 240 Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Gly Arg Asn Ala Thr Thr 245 250 255 Ala Gly Leu Thr Pro Glu Ile Val Leu Tyr Thr Glu Asn Val Asp Leu 260 265 270 Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr Asp Asp Ser 275 280 285 Ser Ser Ser Ile Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro Asn 290 295 300 Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr Asn Ser 305 310 315 320 Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu Asn Ala 325 330 335 Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln Leu Leu 340 345 350 Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp Asn Gln 355 360 365 Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn His Gly 370 375 380 Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Ala Val Gly 385 390 395 400 Arg Thr Asp Ser Tyr Gln Gly Ile Lys Pro Asn Gly Gly Asp Pro Ala 405 410 415 Thr Trp Ala Lys Asp Glu Ser Val Asn Asp Ser Asn Glu Leu Gly Lys 420 425 430 Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg 435 440 445 Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys 450 455 460 Tyr Thr Pro Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp 465 470 475 480 Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ala Tyr Ile 485 490 495 Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro 500 505 510 Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu Leu 515 520 525 Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln Lys Phe 530 535 540 Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr Thr Tyr Glu 545 550 555 560 Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser Ser Leu Gly 565 570 575 Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ala Phe Thr Ser Ile Asn 580 585 590 Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala Ser Thr Leu 595 600 605 Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr 610 615 620 Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn 625 630 635 640 Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp 645 650 655 Ser Phe Thr Arg Leu Lys Thr Arg Glu Thr Pro Ser Leu Gly Ser Gly 660 665 670 Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly 675 680 685 Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp 690 695 700 Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu 705 710 715 720 Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln 725 730 735 Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr 740 745 750 Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp Arg 755 760 765 Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln Val Val 770 775 780 Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu Thr Tyr Gln 785 790 795 800 His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr Met Arg Gln 805 810 815 Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile Gly Lys Ser 820 825 830 Ala Val Ala Ser Val Thr Gln Lys Lys Phe Leu Cys Asp Arg Val Met 835 840 845 Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr 850 855 860 Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp 865 870 875 880 Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val 885 890 895 Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly 900 905 910 Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala 915 920 925 Thr Thr 930 <210> 76 <211> 207 <212> PRT <213> Simian adenovirus 38 <400> 76 Met Thr Ala Cys Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Leu Arg 1 5 10 15 Asp Leu Gly Cys Gly Pro Cys Phe Leu Gly Thr Phe Asp Lys Arg Phe 20 25 30 Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr 35 40 45 Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn 50 55 60 Pro Arg Ser His Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp 65 70 75 80 Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg 85 90 95 Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser 100 105 110 Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe Cys 115 120 125 Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met Asp 130 135 140 Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met Leu 145 150 155 160 Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala Leu 165 170 175 Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg Ala 180 185 190 Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 77 <211> 795 <212> PRT <213> Simian adenovirus 38 <400> 77 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Asp 1 5 10 15 Glu Asn Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 20 25 30 Thr Ser Asp Ala Ala Pro Asp Met Gln Glu Met Glu Glu Ser Ile Glu 35 40 45 Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu Glu Leu Ala 50 55 60 Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln Pro Glu Gln 65 70 75 80 Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly Leu Glu His Gly Asp Tyr 85 90 95 Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu Ala Arg Gln Cys 100 105 110 Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu Val Pro Leu Ser 115 120 125 Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe Ser Pro Arg 130 135 140 Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg 145 150 155 160 Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr Tyr 165 170 175 His Ile Phe Phe Lys Asn Gln Lys Ile Pro Val Ser Cys Arg Ala Asn 180 185 190 Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro Gly Ala Arg Leu 195 200 205 Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu 210 215 220 Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Asn Glu Glu 225 230 235 240 His Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg 245 250 255 Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro 260 265 270 Ala Leu Asn Leu Pro Pro Lys Val Met Asn Ala Val Met Asp Gln Val 275 280 285 Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu Met Gln Asp Pro 290 295 300 Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp Glu Gln Leu Ala 305 310 315 320 Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln Ser Leu Glu Glu Arg Arg 325 330 335 Lys Leu Met Met Ala Val Val Leu Val Thr Val Glu Leu Glu Cys Leu 340 345 350 Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn 355 360 365 Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile 370 375 380 Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His 385 390 395 400 Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu 405 410 415 Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His 420 425 430 Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln 435 440 445 Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu 450 455 460 Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ala Asp Leu Ala Asp Leu 465 470 475 480 Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp 485 490 495 Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu 500 505 510 Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp Phe 515 520 525 Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser His Cys 530 535 540 Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser Asp Val Ile 545 550 555 560 Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His Cys Arg Cys Asn 565 570 575 Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser 580 585 590 Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly Pro Gly Asp Ser 595 600 605 Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala 610 615 620 Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile Arg 625 630 635 640 Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser Ala Cys 645 650 655 Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys 660 665 670 Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp 675 680 685 Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Pro 690 695 700 Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Gly Gly Phe Gly 705 710 715 720 Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Gly Asp Gly Arg Leu Gly 725 730 735 Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Gly 740 745 750 Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln Thr 755 760 765 Val Val Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg 770 775 780 Ser Gly Ser Gly Ser Arg Arg Ser Gly Pro Gln 785 790 795 <210> 78 <211> 227 <212> PRT <213> Simian adenovirus 38 <400> 78 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 79 <211> 106 <212> PRT <213> Simian adenovirus 38 <400> 79 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 80 <211> 206 <212> PRT <213> Simian adenovirus 38 <400> 80 Met Ala Ser Val Lys Phe Phe Ala Leu Phe Ala Ser Leu Ile Thr Val 1 5 10 15 Ile His Gly Met Ser Asn Glu Lys Ile Thr Ile Tyr Thr Gly Thr Asn 20 25 30 His Thr Leu Lys Gly Pro Glu Lys Ala Thr Glu Val Ser Trp Tyr Cys 35 40 45 Tyr Phe Asn Glu Ser Asp Val Ala Thr Glu Leu Cys Gly Asn Asn Asn 50 55 60 Lys Lys Asn Glu Ser Ile Thr Leu Ile Lys Phe Gln Cys Gly Ser Asp 65 70 75 80 Leu Thr Leu Ile Asn Ile Thr Arg Asp Tyr Val Gly Met Tyr Tyr Gly 85 90 95 Thr Thr Ala Gly Ile Ser Asp Met Glu Phe Tyr Gln Val Ser Val Ser 100 105 110 Glu Pro Thr Thr Pro Arg Met Thr Thr Thr Thr Lys Thr Thr Pro Thr 115 120 125 Thr Thr Thr Gln Leu Thr Thr Asn Gly Phe Phe Ala Met Leu Gln Val 130 135 140 Ala Glu Asn Ser Thr Ser Ile Gln Pro Thr Pro Pro Ser Glu Glu Ile 145 150 155 160 Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val Val Val Cys Met Leu 165 170 175 Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His 180 185 190 Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser Val Glu Phe 195 200 205 <210> 81 <211> 203 <212> PRT <213> Simian adenovirus 38 <400> 81 Met Lys Ile Leu Cys Leu Leu Val Phe Tyr Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Lys Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys 50 55 60 Thr Ser Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Pro Ala Thr Thr Thr His Thr Thr His Thr 115 120 125 Glu Gln Ser Thr Ala Glu Ala Ala Lys Leu Ala Leu Gln Val Gln Asp 130 135 140 Ser Ser Phe Val Gly Ile Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Leu Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 82 <211> 288 <212> PRT <213> Simian adenovirus 38 <400> 82 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Asn Ser Lys Ile Thr Arg Val Ser Phe Ile Lys His Val Asn Val 20 25 30 Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu Gly Ala Gln Asn 35 40 45 Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg Asp Ile Cys Thr Trp 50 55 60 Asn Val Thr Tyr Tyr Cys Ile Gly Val Asn Leu Thr Ile Val Asn Ala 65 70 75 80 Asn Gln Ser Gln Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr 85 90 95 Ser Asp Gly Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val 100 105 110 Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Ala Gln Thr Thr 115 120 125 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 130 135 140 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 145 150 155 160 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 165 170 175 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr 180 185 190 Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 195 200 205 Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 210 215 220 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu 225 230 235 240 Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His 245 250 255 Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro Glu Pro Leu 260 265 270 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 83 <211> 91 <212> PRT <213> Simian adenovirus 38 <400> 83 Met Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Val Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 50 55 60 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Arg Val Ala Gln Leu Leu Arg Leu Leu 85 90 <210> 84 <211> 135 <212> PRT <213> Simian adenovirus 38 <400> 84 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 85 <211> 425 <212> PRT <213> Simian adenovirus 38 <400> 85 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Glu Gly Val Asp Leu Asp Ser Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Ala Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp His Pro Phe Tyr Thr Lys Asp Gly Lys Leu 100 105 110 Ala Leu Gln Val Ser Pro Pro Leu Asn Ile Leu Arg Thr Ser Ile Leu 115 120 125 Asn Thr Leu Ala Leu Gly Phe Gly Ser Gly Leu Gly Leu Arg Gly Ser 130 135 140 Ala Leu Ala Val Gln Leu Val Ser Pro Leu Thr Phe Asp Thr Asp Gly 145 150 155 160 Asn Ile Lys Leu Thr Leu Asp Arg Gly Leu His Val Thr Thr Gly Asp 165 170 175 Ala Ile Glu Ser Asn Ile Ser Trp Ala Lys Gly Leu Lys Phe Glu Asp 180 185 190 Gly Ala Ile Ala Thr Asn Ile Gly Asn Gly Leu Glu Phe Gly Ser Ser 195 200 205 Ser Thr Glu Thr Gly Val Asp Asp Ala Tyr Pro Ile Gln Val Lys Leu 210 215 220 Gly Ser Gly Leu Ser Phe Asp Ser Thr Gly Ala Ile Met Ala Gly Asn 225 230 235 240 Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro 245 250 255 Asn Cys Gln Ile Leu Ala Glu Asn Asp Ala Lys Leu Thr Leu Cys Leu 260 265 270 Thr Lys Cys Gly Ser Gln Ile Leu Ala Thr Val Ser Val Leu Val Val 275 280 285 Gly Ser Gly Asn Leu Asn Pro Ile Thr Gly Thr Val Ser Ser Ala Gln 290 295 300 Val Phe Leu Arg Phe Asp Ala Asn Gly Val Leu Leu Thr Glu His Ser 305 310 315 320 Thr Leu Lys Lys Tyr Trp Gly Tyr Arg Gln Gly Asp Ser Ile Asp Gly 325 330 335 Thr Pro Tyr Ala Asn Ala Val Gly Phe Met Pro Asn Leu Lys Ala Tyr 340 345 350 Pro Lys Ser Gln Ser Ser Thr Thr Lys Asn Asn Ile Val Gly Gln Val 355 360 365 Tyr Met Asn Gly Asp Val Ser Lys Pro Met Leu Leu Thr Ile Thr Leu 370 375 380 Asn Gly Thr Asp Asp Ser Asn Ser Thr Tyr Ser Met Ser Phe Ser Tyr 385 390 395 400 Thr Trp Thr Asn Gly Ser Tyr Val Gly Ala Thr Phe Gly Ala Asn Ser 405 410 415 Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 420 425 <210> 86 <211> 580 <212> DNA <213> Simian adenovirus 38 <220> <221> CDS <222> (1)..(576) <223> label=Elb\19K <400> 86 atg gag atc tgg acg gtc ttg gaa gac ttt cat cag act aga cag ctg 48 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 cta gag aac tca tcg gag gaa gtc tct tac ctg tgg aga ttt tgc ttc 96 Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 ggt ggg gct cta gct aag cta gtc tat agg gcc aaa cag gat tat aag 144 Gly Gly Ala Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys 35 40 45 gat caa ttt gag gat att ttg aga gag tgt cct ggt att ttt gac tct 192 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 ctc aac ttg ggc cat cag tct cac ttt aac cag agt att ctg aga gcc 240 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 ctt gac ttt tct act cct ggc aga act acc gcc gcg gta gcc ttt ttt 288 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 gcc ttt atc ctt gac aaa tgg agt caa gaa acc cat ttc agc agg gat 336 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 tac cgt ctg gac tgc tta gca gta gct ttg tgg aga aca tgg agg tgc 384 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 cag cgc ctg aat gca atc tcc ggc tac ttg cca gta cag ccg gta gac 432 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 acg ctg agg atc ctg agt ctc cag tca ccc cag gaa cac caa cgc cgc 480 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 cag cag ccg cag cag gag cag cag caa gag gag gag gag gac cga gaa 528 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu 165 170 175 gag aac ccg aga gcc ggt ctg gac cct ccg gtg gcg gag gag gag gag 576 Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 tagc 580 <210> 87 <211> 192 <212> PRT <213> Simian adenovirus 38 <400> 87 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Ala Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys 35 40 45 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu 165 170 175 Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 88 <211> 530 <212> DNA <213> Simian adenovirus 38 <220> <221> CDS <222> (1)..(528) <223> label=E3\gp19K <400> 88 atg ggg aag atc acc cta gtg agc tgc ggt gcg ctg gtg gcg gtg gtg 48 Met Gly Lys Ile Thr Leu Val Ser Cys Gly Ala Leu Val Ala Val Val 1 5 10 15 ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag aag gcc 96 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 gat ccc tgc ttg cat ttc aat ccc gac aaa tgc cag ctg agt ttt cag 144 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc gga tgg gaa tgc 192 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 gag aac gtg aga atc gag tac aat aac aag act cgg aac aat act ctc 240 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 gcg tcc gtg tgg cag ccc ggg gac ccc gag tgg tac acc gtc tct gtc 288 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 ccc ggt gct gac ggc tcc ccg cgc acc gtg aac aat act ttc att ttt 336 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 gca cac atg tgc gac acg gtc atg tgg atg agc aag cag tac gat atg 384 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 tgg ccc ccc acg aag gag aac atc gtg gtc ttc tcc atc gct tac agc 432 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 ctg tgc acg gcg cta atc acc gct atc gtg tgc ctg agc att cac atg 480 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 ctc atc gct att cgc ccc aga aat aat gcc gaa aaa gag aaa cag cca 528 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 ta 530 <210> 89 <211> 176 <212> PRT <213> Simian adenovirus 38 <400> 89 Met Gly Lys Ile Thr Leu Val Ser Cys Gly Ala Leu Val Ala Val Val 1 5 10 15 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 90 <211> 5900 <212> DNA <213> Simian adenovirus 38 <220> <221> CDS <222> (4)..(573) <223> label=22K <220> <221> CDS <222> (1880)..(2506) <223> label=E3\CR1\alpha <220> <221> CDS <222> (5465)..(5893) <223> label=E3\RID\beta <400> 90 agg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg ccg 48 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro 1 5 10 15 gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag atg 96 Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac agt 144 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca gcc 192 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 gcc gcc aga ccg tcg tcc tcg gcg gag gag aaa gca agc agc acg gat 240 Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp 65 70 75 acc atc tcc gct ccg ggt cgg ggt cgc ggc ggt cgg gcc cac agt aga 288 Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg 80 85 90 95 tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc ggt aag 336 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys 100 105 110 aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc atc 384 Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile 115 120 125 gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg cgc 432 Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg 130 135 140 tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg cat 480 Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His 145 150 155 tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa gag gca 528 Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala 160 165 170 175 gaa acc cag cag cag cag aaa acc agc ggc agc agc agc agc agc 573 Glu Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser Ser Ser 180 185 190 tagaaaatcc acagcggcgg cggcggcagg tggactgagg atcgcggcga acgagccggc 633 gcagacccgg gagctgagga accggatctt tcccaccctc tatgccatct tccagcagag 693 tcgggggcag gagcaggaac tgaaagtcaa gaaccgttct ctgcgctcgc tcacccgcag 753 ttgtctgtat cacaagagcg aagaccaact tcagcgcact ctcgaggacg ccgaggctct 813 cttcaacaag tactgcgcgc tcactcttaa agagtagccc gcgcccgccc acacacggaa 873 aaaggcggga attacgtcac cacctgcgcc cttcgcccga ccatcatcat gagcaaagag 933 attcccacgc cttacatgtg gagctaccag ccccagatgg gcctggccgc cggcgccgcc 993 caggactact ccacccgcat gaactggctc agtgccgggc ccgcgatgat ctcacgggtg 1053 aatgacatcc gcgcccaccg aaaccagata ctcctagaac agtcagcgat caccgccacg 1113 ccccgccatc accttaatcc gcgtaattgg cccgccgccc tggtgtacca ggaaattccc 1173 cagcccacga ccgtactact tccgcgagac gcccaggccg aagtccagct gactaactca 1233 ggtgtccagc tggccggcgg cgccgccctg tgtcgtcacc gccccgctca gggtataaag 1293 cggctggtga tccgaggcag aggcacacag ctcaacgacg aggtggtgag ctcttcgctg 1353 ggtctgcgac ctgacggagt cttccaactc gccggatcgg ggagatcttc cttcacgcct 1413 cgtcaggccg tcctgacttt ggagagttcg tcctcgcagc cccgctcggg cggcatcggc 1473 actctccagt tcgtggagga gttcactccc tcggtctact tcaacccctt ctccggctcc 1533 cccggccact acccggacga gttcatcccg aacttcgacg ccatcagcga gtcggtggac 1593 ggctacgatt gaatgtccca tggtggcgcg gctgacctag ctcggcttcg acacctggac 1653 cactgccgcc gcttccgctg cttcgctcgg gatctcgccg agtttgccta ctttgagctg 1713 cccgaggagc accctcaggg cccggcccac ggagtgcgga tcgtcgtcga agggggcctc 1773 gactcccacc tgcttcggat cttcagccag cgaccgatcc tggtcgagcg cgagcaagga 1833 cagacccgtc tgaccctgta ctgcatctgc aaccaccccg gcctgc atg aaa gtc 1888 Met Lys Val ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct gag atc agc gac 1936 Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp 195 200 205 tac tcc gga ctc gat tgt ggt gtt cct gct atc aac cgg tcc ctg ttc 1984 Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg Ser Leu Phe 210 215 220 225 ttc acc ggg aac gag acc gag ctc cag ctc cag tgt aag ccc cac aag 2032 Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys 230 235 240 aag tat ctc acc tgg ctg ttc cag ggc tcc ccg atc gcc gtt gtc aac 2080 Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn 245 250 255 cac tgc gac aac gac gga gtc ctg ctg agc ggc ccc gcc aac ctt act 2128 His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr 260 265 270 ttt tcc acc cgc aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc 2176 Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro 275 280 285 ggg acc tat cag tgc ctc tcg gga ccc tgc cat cac acc ttc cac ctg 2224 Gly Thr Tyr Gln Cys Leu Ser Gly Pro Cys His His Thr Phe His Leu 290 295 300 305 atc ccg aat acc aca gcg gcg ctc ccc gct act aac aac caa act acc 2272 Ile Pro Asn Thr Thr Ala Ala Leu Pro Ala Thr Asn Asn Gln Thr Thr 310 315 320 cac caa cgc cac cgt cgc gac ctt tcc tct gaa tct aat act acc acc 2320 His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr 325 330 335 cac acc gga ggt gag ctc cga ggt caa cca acc tct ggg att tac tac 2368 His Thr Gly Gly Glu Leu Arg Gly Gln Pro Thr Ser Gly Ile Tyr Tyr 340 345 350 ggc ccc tgg gag gtg gtg ggg tta ata gcg cta ggc cta gtt gcg ggt 2416 Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Ala Gly 355 360 365 ggg ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt tct tac tta 2464 Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu 370 375 380 385 gtg gtg ctg tgt tgc tgg ttt aag aaa tgg gga aga tca ccc 2506 Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 390 395 tagtgagctg cggtgcgctg gtggcggtgg tgctttcgat tgtgggactg ggcggcgcgg 2566 ctgtagtgaa ggagaaggcc gatccctgct tgcatttcaa tcccgacaaa tgccagctga 2626 gttttcagcc cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga 2686 acgtgagaat cgagtacaat aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc 2746 ccggggaccc cgagtggtac accgtctctg tccccggtgc tgacggctcc ccgcgcaccg 2806 tgaacaatac tttcattttt gcacacatgt gcgacacggt catgtggatg agcaagcagt 2866 acgatatgtg gccccccacg aaggagaaca tcgtggtctt ctccatcgct tacagcctgt 2926 gcacggcgct aatcaccgct atcgtgtgcc tgagcattca catgctcatc gctattcgcc 2986 ccagaaataa tgccgaaaaa gagaaacagc cataacacgt tttttcacac acctttttca 3046 gaccatggcc tctgttaaat tttttgcttt atttgccagt ctcattaccg tcattcatgg 3106 aatgagtaat gagaaaatta ctatttacac tggcactaat cacacattga aaggtccaga 3166 aaaagccaca gaagtttcat ggtattgtta ttttaatgaa tcagatgtag ctactgaact 3226 ctgtggaaac aacaacaaaa aaaatgagag cattactctc atcaagtttc aatgtggatc 3286 tgacttaacc ctcattaaca tcactagaga ctatgtaggt atgtattatg gaactacagc 3346 aggcatttcg gacatggaat tttatcaagt ttctgtgtct gaacccacca cgcctagaat 3406 gaccacaacc acaaaaacta cacctactac caccacacag ctcactacca atggcttttt 3466 tgccatgctt caagtggctg aaaatagcac cagcattcaa cccaccccac ccagtgagga 3526 aattcccaaa tccatgattg gcattattgt tgctgtagtg gtgtgcatgt tgatcatcgc 3586 cttgtgcatg gtgtactatg ccttctgcta cagaaagcac agactgaacg acaagctgga 3646 acacttacta agtgttgaat tttaattttt tagaaccatg aagatcctat gccttttagt 3706 tttttatatc attacctctg ctctttgtga atcagtggat aaagatgtta ctattaccac 3766 tggttctaat tatacactga aaggaccacc ctcaggtatg ctttcgtggt attgctattt 3826 tggaactgac actgatcaaa ctgaattatg caattttcaa aaaggcaaaa cctcaaactc 3886 taaaatctct aattatcaat gcaatggcac tgatctgata ctactcaatg tcacgaaagc 3946 atatggtggc agttattcat gccctggaca aaacactgaa gaaatgattt tttacaaagt 4006 ggaagtggtt gatcccacta ctccacctcc acccgccaca actactcaca ccacacacac 4066 agaacaaagc acagcagagg cagcaaagtt agccttgcag gtccaagaca gttcatttgt 4126 tggcattacc cctacacctg atcagcggtg tccggggctg ctcgtcagcg gcattgtcgg 4186 tgtgctttcg ggattagcag tcataatcat ctgcatgttc atttttgctt gctgctatag 4246 aaggctttac cgacaaaaat cagacccact gctgaacctc tatgtttaat tttttccaga 4306 gccatgaagg cagttagcgc tctagttttt tgttctttga ttggcattgt ttttaatagt 4366 aaaattacca gagttagctt tattaaacat gttaatgtaa ctgaaggaga taacatcaca 4426 ctagcaggtg tagaaggtgc tcaaaacacc acctggacaa aataccatct aggatggaga 4486 gatatttgca cctggaatgt aacttattat tgcataggag ttaatcttac cattgttaac 4546 gctaaccaat ctcagaatgg gttaattaaa ggacagagtg ttagtgtgac cagtgatggg 4606 tactataccc agcatagttt taactacaac attactgtca taccactgcc tacgcctagc 4666 ccacctagca ctaccgcaca gacaaccaca tacagtacat caaatcagcc taccaccact 4726 acagcagcag aggttgccag ctcgtctggg gtccgagtgg catttttgat gttggcccca 4786 tctagcagtc ccactgctag taccaatgag cagactactg aatttttgtc cactgtcgag 4846 agccacacca cagctacctc cagtgccttc tctagcaccg ccaatctctc ctcgctttcc 4906 tctacaccaa tcagtcccgc tactactcct agccccgctc ctcttcccac tcccctgaag 4966 caaacagacg gcggcatgca atggcagatc accctgctca ttgtgatcgg gttggtcatc 5026 ctggccgtgt tgctatacta catcttctgc cgccgcattc ccaacgcgca ccgcaagccg 5086 gcctacaagc ccatcgttat cgggcagccg gagccgcttc aggtggaagg gggtctaagg 5146 aatcttctct tctcttttac agtatggtga ttgaactatg attcctagac aattcttgat 5206 cactattctt atctgcctcc tccaagtctg tgccaccctc gctctggtgg ccaacgccag 5266 tccagactgt attggaccct tcgcctccta cgtgctcttt gccttcgtca cctgcatctg 5326 ctgctgtagc atagtctgcc tgcttatcac cttcttccag ttcattgact ggatctttgt 5386 gcgcatcgcc tacctgcgcc accaccccca gtaccgcgac cagcgagtgg cgcagctgct 5446 caggctcctc tgataagc atg cgg gct ctg cta ctt ctc gcg ctt ctg ctg 5497 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu 400 405 410 tta gtg ctc ccc cgt ccc gtt gac ccc cgg ccc ccc act cag tcc ccc 5545 Leu Val Leu Pro Arg Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro 415 420 425 gag gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa ttc ctc aaa 5593 Glu Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys 430 435 440 tgc tac cgc caa aaa tca gac atg cat ccc agc tgg atc atg atc att 5641 Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp Ile Met Ile Ile 445 450 455 ggg atc gtg aac att ctg gcc tgc acc ctc atc tcc ttt gtg att tac 5689 Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr 460 465 470 ccc tgc ttt gac ttt ggt tgg aac tcg cca gag gcg ctc tat ctc ccg 5737 Pro Cys Phe Asp Phe Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro 475 480 485 490 cct gaa cct gac aca cca cca cag caa cct cag gca cac gca cta cca 5785 Pro Glu Pro Asp Thr Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro 495 500 505 cca cca cag cct agg cca caa tac atg ccc ata tta gac tat gag gcc 5833 Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala 510 515 520 gag cca cag cga ccc atg ctc ccc gct att agt tac ttc aat cta acc 5881 Glu Pro Gln Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr 525 530 535 ggc gga gat gac tgaccca 5900 Gly Gly Asp Asp 540 <210> 91 <211> 190 <212> PRT <213> Simian adenovirus 38 <400> 91 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met Glu 20 25 30 Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu 35 40 45 Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu 165 170 175 Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser Ser Ser 180 185 190 <210> 92 <211> 209 <212> PRT <213> Simian adenovirus 38 <400> 92 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Leu Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ala Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr His Thr Gly Gly Glu Leu Arg Gly Gln Pro Thr Ser Gly 145 150 155 160 Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu 165 170 175 Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys 180 185 190 Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser 195 200 205 Pro <210> 93 <211> 143 <212> PRT <213> Simian adenovirus 38 <400> 93 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro Arg 100 105 110 Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro 115 120 125 Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 94 <211> 1440 <212> DNA <213> Simian adenovirus 38 <220> <221> CDS <222> (577)..(1144) <223> label=Ela\13S <220> <221> CDS <222> (1230)..(1435) <223> label=Ela\13S <400> 94 catcatcaaa taatatacct taaacttttg gtgcgcgtta atatgcaaat gaggtatttg 60 aatttgggga tgcggggcgg tgattggctg cgggagcggc gaccgttagg ggcggggcgg 120 gtgacgtttt gatgacgtgt ttgtgaggcg gagccggttt gcaagttctc gtgggaaaag 180 tgacgtcaaa cgaggtgtgg tttgaacacg gaaatactca attttcccgc gctctctgac 240 aggaaatgag gtgtttctgg gcggatgcaa gtgaaaacgg gccattttcg cgcgaaaact 300 gaatgaggaa gtgaaaatct gagtaatttc gcgtttatgg cagggaggag tatttgccga 360 gggccgagta gactttgacc gattacgtgg gggtttcgat taccgtattt ttcacctaaa 420 tttccgcgta cggtgtcaaa gtccggtgtt tttacgtagg tgtcagctga tcgccagggt 480 atttaaacct gcgctctcta gtcaagaggc cactcttgag tgccagcgag tagagttttc 540 tcctccgcgc cgcgagtcag atctacactt tgaaag atg agg cac ctg aga gac 594 Met Arg His Leu Arg Asp 1 5 ctg ccc ggt aat gtt ttc ctg gct act ggg aac gag att ctg gaa ctg 642 Leu Pro Gly Asn Val Phe Leu Ala Thr Gly Asn Glu Ile Leu Glu Leu 10 15 20 gtg gtg gac gcc atg atg ggt gac gac cct ccg gag ccc cct acc cca 690 Val Val Asp Ala Met Met Gly Asp Asp Pro Pro Glu Pro Pro Thr Pro 25 30 35 ttt gag gcg cct tcg ctg tac gat ttg tat gat ctg gag gtg gat gtg 738 Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr Asp Leu Glu Val Asp Val 40 45 50 ccc gag aac gac ccc aac gag gag gcg gtg aat gat ttg ttt agc gat 786 Pro Glu Asn Asp Pro Asn Glu Glu Ala Val Asn Asp Leu Phe Ser Asp 55 60 65 70 gcc gcg ctg ctg gct gcc gag cag gct aat acg gac tct ggc tca gac 834 Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn Thr Asp Ser Gly Ser Asp 75 80 85 agc gat tcc tct ctc cat acc ccg aga ccc ggc aga ggt gag aaa aag 882 Ser Asp Ser Ser Leu His Thr Pro Arg Pro Gly Arg Gly Glu Lys Lys 90 95 100 atc ccc gag ctt aaa ggg gaa gag ctc gac ctg cgc tgc tat gag gaa 930 Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp Leu Arg Cys Tyr Glu Glu 105 110 115 tgc ttg cct ccg agc gat gat gag gag gac gag gag gcg att cga gct 978 Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp Glu Glu Ala Ile Arg Ala 120 125 130 gca gcg aac cag gga gtg aaa gcg gcg ggc gag ggc ttt agc ctg gac 1026 Ala Ala Asn Gln Gly Val Lys Ala Ala Gly Glu Gly Phe Ser Leu Asp 135 140 145 150 tgt cct act ctg ccc gga cac ggc tgt aag tct tgt gaa ttt cat cgc 1074 Cys Pro Thr Leu Pro Gly His Gly Cys Lys Ser Cys Glu Phe His Arg 155 160 165 atg aat act gga gat aag aat gtg atg tgt gcc ctg tgc tat atg aga 1122 Met Asn Thr Gly Asp Lys Asn Val Met Cys Ala Leu Cys Tyr Met Arg 170 175 180 gct tac aac cat tgt gtt tac a gtaagtgtga ttaactttag ttgggaaggc 1174 Ala Tyr Asn His Cys Val Tyr 185 agagggtgac tgggtgctga ctggtttatt tatgtatatg tttttttatg tgtag gt 1231 Ser ccc gtc tct gac gta gat gag acc ccc act tca gag tgc att tca tca 1279 Pro Val Ser Asp Val Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser 195 200 205 ccc cca gaa att ggc gag gaa ccg ccc gaa gat att att cat aga cca 1327 Pro Pro Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro 210 215 220 gtt gca gtg aga gtc acc ggg cgg aga gca gct gtg gag agt ttg gat 1375 Val Ala Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp 225 230 235 gac ttg cta cag ggt ggg gat gaa cct ttg gac ttg tgt acc cgg aaa 1423 Asp Leu Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys 240 245 250 cgc ccc agg cac taagt 1440 Arg Pro Arg His 255 <210> 95 <211> 258 <212> PRT <213> Simian adenovirus 38 <400> 95 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Pro Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Ala Ile Arg Ala Ala Ala Asn Gln Gly Val Lys Ala Ala Gly 130 135 140 Glu Gly Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val 180 185 190 Ser Asp Val Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro 195 200 205 Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val Ala 210 215 220 Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp Leu 225 230 235 240 Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro 245 250 255 Arg His <210> 96 <211> 850 <212> DNA <213> Simian adenovirus 38 <220> <221> CDS <222> (4)..(331) <223> label=33K <220> <221> CDS <222> (501)..(847) <223> label=33K <400> 96 agg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg ccg 48 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro 1 5 10 15 gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag atg 96 Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met 20 25 30 gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac agt 144 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca gcc 192 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 gcc gcc aga ccg tcg tcc tcg gcg gag gag aaa gca agc agc acg gat 240 Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp 65 70 75 acc atc tcc gct ccg ggt cgg ggt cgc ggc ggt cgg gcc cac agt aga 288 Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg 80 85 90 95 tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc g 331 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 100 105 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 391 gcttgcaagc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 451 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 508 Ala Pro Thr act gtt tcc aag aag agg cag aaa ccc agc agc agc aga aaa cca gcg 556 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 gca gca gca gca gca gct aga aaa tcc aca gcg gcg gcg gcg gca ggt 604 Ala Ala Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Ala Ala Gly 130 135 140 gga ctg agg atc gcg gcg aac gag ccg gcg cag acc cgg gag ctg agg 652 Gly Leu Arg Ile Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg 145 150 155 160 aac cgg atc ttt ccc acc ctc tat gcc atc ttc cag cag agt cgg ggg 700 Asn Arg Ile Phe Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly 165 170 175 cag gag cag gaa ctg aaa gtc aag aac cgt tct ctg cgc tcg ctc acc 748 Gln Glu Gln Glu Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr 180 185 190 cgc agt tgt ctg tat cac aag agc gaa gac caa ctt cag cgc act ctc 796 Arg Ser Cys Leu Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu 195 200 205 gag gac gcc gag gct ctc ttc aac aag tac tgc gcg ctc act ctt aaa 844 Glu Asp Ala Glu Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys 210 215 220 gag tag 850 Glu 225 <210> 97 <211> 225 <212> PRT <213> Simian adenovirus 38 <400> 97 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met Glu 20 25 30 Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu 35 40 45 Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro Thr 100 105 110 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 Ala Ala Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Ala Ala Gly 130 135 140 Gly Leu Arg Ile Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg 145 150 155 160 Asn Arg Ile Phe Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly 165 170 175 Gln Glu Gln Glu Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr 180 185 190 Arg Ser Cys Leu Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu 195 200 205 Glu Asp Ala Glu Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys 210 215 220 Glu 225 <210> 98 <211> 36621 <212> DNA <213> Simian adenovirus 30 <220> <221> repeat_region <222> (1)..(126) <223> label=ITR <220> <221> CDS <222> (1906)..(3414) <223> label=Elb\55K <220> <221> CDS <222> (3452)..(3922) <223> label=pIX <220> <221> misc_feature <222> (3988)..(5609) <223> complement(3988..5318,5597..5609) label=IVa2 <220> <221> misc_feature <222> (5091)..(13843) <223> complement(5091..8663,13835..13843) label=pol <220> <221> misc_feature <222> (8465)..(13843) <223> complement(8465..10399,13835..13843) label=pTP <220> <221> CDS <222> (10826)..(12001) <223> label=52K <220> <221> CDS <222> (12028)..(13806) <223> label=pIIIa <220> <221> CDS <222> (13888)..(15486) <223> label=penton <220> <221> CDS <222> (15493)..(16071) <223> label=pVII <220> <221> CDS <222> (16116)..(17153) <223> label=V <220> <221> CDS <222> (17177)..(17407) <223> label=pX <220> <221> CDS <222> (17442)..(18218) <223> label=pVI <220> <221> CDS <222> (18328)..(21141) <223> label=hexon <220> <221> CDS <222> (21160)..(21786) <223> label=protease <220> <221> misc_feature <222> (21871)..(23403) <223> complement label=DBP <220> <221> CDS <222> (23426)..(25828) <223> label=100K <220> <221> CDS <222> (26451)..(27131) <223> label=pVIII <220> <221> CDS <222> (27409)..(28032) <223> label=E3\CR1\alpha <220> <221> CDS <222> (28581)..(29264) <223> label=E3\CR1\beta <220> <221> CDS <222> (29280)..(29888) <223> label=E3\CR1\gamma <220> <221> CDS <222> (29906)..(30769) <223> label=E3\CR1\delta <220> <221> CDS <222> (30780)..(31052) <223> label=E3\RID\alpha <220> <221> CDS <222> (31061)..(31492) <223> label=E3\RID\beta <220> <221> CDS <222> (32189)..(33523) <223> label=fiber <220> <221> misc_feature <222> (33628)..(34772) <223> complement(33628..33876,34623..34772) label=E4\orf6/7 <220> <221> misc_feature <222> (33876)..(34772) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34678)..(35043) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (35055)..(35405) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35405)..(35791) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35844)..(36215) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36496)..(36621) <223> label=ITR <400> 98 catcatcaat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg agccgtttga 60 atttggggat ggaggaaggt gattggctgt gggagcggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtggc catgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaattccg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tcccgagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgtcc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggct gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccccgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgagcgagg gagtgaaagt tgcgggcgag agctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagttgggaa aggcagaggg tgactgggtg ctgactggtt 1200 tatttatgta tatgtttttt atgtgtaggt cccgtctctg acgcagatga gacccccact 1260 tcagagtgca tttcatcacc cccagaaatt ggcgaggaac cgcccgaaga tattattcat 1320 agaccagttg cagtgagagt caccgggcgg agagcagctg tggagagttt ggatgacttg 1380 ctacagggtg gggatgaacc tttggacttg tgtacccgga aacgccccag gcactaagtg 1440 ccacacatgt gtgtttactt aaggtgatgt cagtatttat agggtgtgga gtgcaataaa 1500 aatatgtgtt gactttaagt gcgtgtttta tgactcaggg gtggggactg tgggtatata 1560 agcaggtgca gacctgtgtg gtcagttcag agcaggactc atggagatct ggacagtctt 1620 ggaagacttt caccagacta gacagctgct agagaactca tcggagggag tctcttacct 1680 gtggagattc tgcttcgctg ggcctctagc taagctagtc tatagggcca agcaggatta 1740 tagggaacaa tttgaggata ttttgagaga gtgtcctggt atttttgact ctctcaactt 1800 gggccatcag tctcacttta accagagtat tctgagagcc cttgactttt ctactcctgg 1860 cagaactacc gccgcggtag ccttttttgc ctttatcctt gacaa atg gag tca aga 1917 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1965 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2013 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2061 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2109 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc ggt 2157 Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser Gly 70 75 80 ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg gtg 2205 Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val 85 90 95 100 ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag agg 2253 Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg 105 110 115 cat gag gag act agc cac aga act gaa ctg act gtc agt ctg atg agc 2301 His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met Ser 120 125 130 cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtt cag tcg cag ggg 2349 Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln Gly 135 140 145 gta gat gag gtc tcg gtg atg cat gag aaa tat tcc cta gaa caa gtc 2397 Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln Val 150 155 160 aag act tgt tgg ttg gag ccc gag gat gat tgg gag gta gcc atc agg 2445 Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg 165 170 175 180 aat tat gcc aag ctg gct ctg agg cca gac aag aag tac aag att acc 2493 Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys Tyr Lys Ile Thr 185 190 195 aaa ctg att aat atc aga aat tcc tgc tac att tca ggg aat ggg gcc 2541 Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly Ala 200 205 210 gag gtg gag atc agt acc cag gag agg gtg gct ttc aga tgc tgc atg 2589 Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys Met 215 220 225 atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt atg 2637 Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe Met 230 235 240 aac gcg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg gcc 2685 Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met Ala 245 250 255 260 aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat aac 2733 Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn 265 270 275 atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc ttt 2781 Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser Phe 280 285 290 tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg tca 2829 Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val Ser 295 300 305 gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc gag 2877 Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser Glu 310 315 320 ggc gaa gcc aaa gtc aaa cac tgc gcc tct acc gag acg ggc tgc ttt 2925 Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys Phe 325 330 335 340 gtg tgt atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt ggg 2973 Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys Gly 345 350 355 gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg aac 3021 Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn 360 365 370 agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag aca 3069 Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys Thr 375 380 385 tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac ctg 3117 Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His Leu 390 395 400 ggc tcc cgc cga ggc atg ttc atg cca tac cag tgc aac atg caa ttt 3165 Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln Phe 405 410 415 420 gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg gcg 3213 Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Ala 425 430 435 ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat gat 3261 Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr Asp 440 445 450 gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac gcc 3309 Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala 455 460 465 agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc gat 3357 Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro Asp 470 475 480 cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg gaa 3405 His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly Glu 485 490 495 500 gaa tct gac tagagtgagt agtgtttggg ggcgggtggg agcctgc atg agg ggc 3460 Glu Ser Asp Met Arg Gly 505 aga atg act aaa atc tgt gtt ttt ctg tgc agc agc atg agc gga agc 3508 Arg Met Thr Lys Ile Cys Val Phe Leu Cys Ser Ser Met Ser Gly Ser 510 515 520 gcc tcc ttt gag gga ggg gta ttc agc cct tat ctg acg ggg cgt ctc 3556 Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg Leu 525 530 535 ccc tcc tgg gcg gga gtg cgt cag aat gtg atg gga tct acg gtg gac 3604 Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser Thr Val Asp 540 545 550 ggc cgg ccc gtg cag ccc gcg aac tct tca acc ctg acc tac gcg acc 3652 Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala Thr 555 560 565 570 ctg agc tcc tcg tcc gtg gac gca gct gcc gcc gca gct gct gct tcc 3700 Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala Ala Ala Ser 575 580 585 gcc gcc agc gcc gtg cgc gga atg gcc ctg ggc gcc ggc tac tac agc 3748 Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly Tyr Tyr Ser 590 595 600 tct ctg gtg gcc aac tcg agt tcc acc aat aat ccc gcc agc ctg aac 3796 Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu Asn 605 610 615 gag gag aag ctg ctg ctg ctg atg gcc cag ctc gag gcc ctg acc cag 3844 Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala Leu Thr Gln 620 625 630 cgc ctg ggc gag ctg acc cag cag gtg gct cag ctg cag gcg gag acg 3892 Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln Ala Glu Thr 635 640 645 650 cgg gcc gcg gtt gcc acg gtg aaa acc aaa taaaaaatga atcaataaat 3942 Arg Ala Ala Val Ala Thr Val Lys Thr Lys 655 660 aaacggagac ggttgttgat tttaacacag agtcttgaat ctttatttga tttttcgcgc 4002 gcggtaggcc ctggaccacc ggtctcgatc attgagcacc cggtggatct tttccaggac 4062 ccggtagagg tgggcttgga tgttgaggta catgggcatg agcccgtccc gggggtggag 4122 gtagctccat tgcagggcct cgtgctcggg ggtggtgttg taaatcaccc agtcatagca 4182 ggggcgcagt gcgtggtgct gcacgatgtc cttgaggagg agactgatgg ccacgggcag 4242 ccccttggtg taggtgttga cgaacctgtt gagctgggag ggatgcatgc ggggggagat 4302 gagatgcatc ttggcctgga tcttgagatt ggcgatgttc ccgcccagat cccgccgggg 4362 gttcatgttg tgcaggacca ccagcacggt gtatccggtg cacttgggga atttgtcatg 4422 caacttggaa gggaaggcgt gaaagaattt ggagacgccc ttgtgaccgc ccaggttttc 4482 catgcactca tccatgatga tggcgatggg cccgtgggcg gcggcctggg caaagacgtt 4542 tcgggggtcg gacacatcgt agttgtggtc ctgggtgagc tcgtcatagg ccattttaat 4602 gaatttgggg cggagggtgc ccgactgggg gacgaaggtg ccttcgatcc cgggggcgta 4662 gttgccctcg cagatctgca tctcccaggc cttgagctcg gaggggggga tcatgtccac 4722 ctgcggggcg atgaaaaaaa cggtttccgg ggcgggggag atgagctgcg ccgaaagcag 4782 gttccggagc agctgggact tgccgcagcc ggtggggccg tagatgaccc cgatgaccgg 4842 ctgcaggtgg tagttgaggg agagacagct gccgtcctcg cgtaggaggg gggccacctc 4902 gttcatcatc tcgcgcacat gcatgttctc gcgcacgagt tccgccagga ggcgctcgcc 4962 ccccagcgag aggagctctt gcagcgaggc gaagtttttc agcggcttga gcccgtcggc 5022 catgggcatt ttggagaggg tctgttgcaa gagttccaga cggtcccaga gctcggtgat 5082 gtgctctacg gcatctcgat ccagcagacc tcctcgtttc gcgggttggg acgactgcgg 5142 gagtagggca ccagacgatg ggcgtccagc gcagccaggg tccggtcctt ccagggtcgc 5202 agcgtccgcg tcagcgtggt ctccgtcacg gtgaaggggt gcgcgccggg ctgggcgctt 5262 gcgagggtgc gcttcaggct catccggctg gtcgagaacc gctcccgatc ggcgccctgc 5322 gcgtcggcca ggtagcaatt gaccatgagt tcgtagttga gcgcctcggc cgcgtggcct 5382 ttggcgcgga gcttaccttt ggaagtctgc ccgcaggcgg gacagaggag ggacttgagg 5442 gcgtagagct tgggggcgag gaagacggac tcgggggcgt aggcgtccgc gccgcagtgg 5502 gcgcagacgg tctcgcactc cacaagccag gtgaggtcgg ggcggtcggg gtcaaaaacg 5562 aggtttcctc cgtgcttttt gatgcgtttc ttacctctgg tctccatgag ctcgtgtccc 5622 cgctgggtga caaagaggct gtccgtgtcc ccgtagaccg actttatggg ccggtcctcg 5682 agcggggtgc cgcggtcctc gtcgtagagg aaccccgccc actccgagac gaaggcccgg 5742 gtccaggcca gcacgaagga ggccacgtgg gaggggtagc ggtcgttgtc caccagcggg 5802 tccaccttct ccagggtatg caagcacatg tccccctcgt ccacatccag gaaggtgatt 5862 ggcttgtaag tgtaggccac gtgaccgggg gtcccggccg ggggggtata aaagggggcg 5922 ggcccctgct cgtcctcact gtcttccgga tcgctgtcca ggagcgccag ctgttggggt 5982 aggtattccc tctcgaaggc gggcatgacc tcggcactca ggttgtcagt ttctagaaac 6042 gaggaggatt tgatattgac ggtgccgttg gagacgcctt tcatgagccc ctcgtccatc 6102 tggtcagaaa agacgatctt tttgttgtcg agcttggtgg cgaaggagcc gtagagggcg 6162 ttggagagca gcttggcgat ggagcgcatg gtctggttct tttccttgtc ggcgcgctcc 6222 ttggcggcga tgttgagctg cacgtactcg cgcgccacgc acttccattc ggggaagacg 6282 gtggtgagct cgtcgggcac gattctgacc cgccagccgc ggttgtgcag ggtgatgagg 6342 tccacgctgg tggccacctc gccgcgcagg ggctcgttgg tccagcagag gcgcccgccc 6402 ttgcgcgagc agaagggggg cagcgggtcc agcatgagct cgtcgggggg gtcggcgtcc 6462 acggtgaaga tgccgggcag gagctcgggg tcgaagtagc tgatgcaggt gcccagatcg 6522 tccagcgccg cttgccagtc gcgcacggcc agcgcgcgct cgtaggggct gaggggcgtg 6582 ccccagggca tggggtgcgt gagcgcggag gcgtacatgc cgcagatgtc gtagacgtag 6642 aggggctcct cgaggacgcc gatgtaggtg gggtagcagc gccccccgcg gatgctggcg 6702 cgcacgtagt cgtacagctc gtgcgagggc gcgaggagcc ccgcgccgag gttggagcgc 6762 tgcggctttt cggcgcggta gacgatctgg cggaagatgg cgtgggagtt ggaggagatg 6822 gtgggcctct ggaagatgtt gaagtgggcg tggggcaggc cgaccgagtc cctgatgaag 6882 tgggcgtagg agtcctgcag cttggcgacg agctcggcgg tgacgaggac gtccagggcg 6942 cagtagtcga gggtctcttg gatgatgtcg tacttgagct ggcccttctg cttccacagc 7002 tcgcggttga gaaggaactc ttcgcggtcc ttccagtact cttcgagggg gaacccgtcc 7062 tgatcggcac ggtaagagcc caccatgtag aactggttga cggccttgta ggcgcagcag 7122 cccttctcca cggggagggc ataagcttgc gcggccttgc gcagggaggt gtgggtgagg 7182 gcgaaggtgt cgcgcaccat gaccttgagg aactggtgct tgaagtcgag gtcgtcgcag 7242 ccgccctgct cccagagttg gaagtccgtg cgcttcttgt aggcggggtt gggcaaagcg 7302 aaagtaacat cgttgaagag gatcttgccc gcgcggggca tgaagttgcg agtgatgcgg 7362 aaaggctggg gcacctcggc ccggttgttg atgacctggg cggcgaggac gatctcgtcg 7422 aagccgttga tgttgtgccc gacgatgtag agttccacga atcgcgggcg gcccttgacg 7482 tggggcagct tcttgagctc gtcgtaggtg agctcggcgg ggtcgctgag gccgtgctgc 7542 tcaagggccc agtcggcgac gtgggggttg gcgctgagga aggaagtcca gagatccacg 7602 gccagggcgg tttgcaagcg gtcccggtac tgacggaact gctggcccac ggccattttt 7662 tcgggggtga tgcagtagaa ggtgcggggg tcgccgtgcc agcggtccca cttgagctgg 7722 agggcgaggt cgtgggcgag ctcgacgagc ggcgggtccc cggagagttt catgaccagc 7782 atgaagggga cgagctgctt gccgaaggac cccatccagg tgtaggtttc cacatcgtag 7842 gtgaggaaga gcctttcggt gcgaggatgc gagccgatgg ggaagaactg gatctcctgc 7902 caccagttgg aggaatggct gttgatgtga tggaagtaga aatgccgacg gcgcgccgag 7962 cactcgtgct tgtgtttata caagcgtccg cagtgctcgc aacgctgcac gggatgcacg 8022 tgctgcacga gctgtacctg ggttcctttg acgaggaatt tcagtgggca gtggagcgct 8082 ggcggctgca tctggtgctg tactacgtcc tggccatcgg cgtggccatc gtctgcctcg 8142 atggtggtca tgctgacgag cccgcgcggg aggcaggtcc agacctcggc tcggacgggt 8202 cggagagcga ggacgagggc gcgcaggccg gagctgtcca gggtcctgag acgctgcgga 8262 gtcaggtcag tgggcagcgg cggcgcgcgg ttgacttgca ggagcttttc cagggcgcgc 8322 gggaggtcca gatggtactt gatctccacg gcgccgttgg tggcgacgtc cacggcttgc 8382 agggtcccgt gcccctgggg cgccaccacc gtgccccgtt tcttcttggg cgctggcgtt 8442 ggcgctgctt ccatgtcggt cagaagcggc ggcgaggacg cgcgccgggc ggcaggggcg 8502 gctcggggcc cggaggcagg ggcggcaggg gcacgtcggc gccgcgcgcg ggcaggttct 8562 ggtactgcgc ccggagaaga ctggcgtgag cgacgacgcg acggttgacg tcctggatct 8622 gacgcctctg ggtgaaggcc acgggacccg tgagtttgaa cctgaaagag agttcgacag 8682 aatcaatctc ggtatcgttg acggcggcct gccgcaggat ctcttgcacg tcgcccgagt 8742 tgtcctggta ggcgatctcg gtcatgaact gctcgatctc ctcctcctga aggtctccgc 8802 ggccggcgcg ctcgacggtg gccgcgaggt cgttggagat gcggcccatg agctgcgaga 8862 aggcgttcat gccggcttcg ttccagacgc ggctgtagac cacggctccg tcggggtcgc 8922 gcgcgcgcat gaccacctgg gcgaggttga gctcgacgtg gcgcgtgaag accgcgtagt 8982 tgcagaggcg ctggtagagg tagttgagcg tggtggcgat gtgctcggtg acgaagaagt 9042 acatgatcca gcggcggagc ggcatctcgc tgacgtcgcc cagggcttcc aaacgttcca 9102 tggcctcgta aaagtccacg gcgaagttga aaaactggga gttgcgcgcc gagacggtca 9162 actcctcctc cagaagacgg atgagctcgg cgatggtggc gcgcacctcg cgctcgaagg 9222 cccccgggag ttcctccact tcctcttctt cttcctcctc cactaacatc tcttctactt 9282 cctcctcagg cggcagtggt ggcgggggag ggggcctgcg tcgccggcgg cgcacgggca 9342 gacggtcgat gaagcgctcg atggtctcgc cgcgccggcg tcgcatggtc tcggtgacgg 9402 cgcgcccgtc ctcgcggggc cgcagcgtga agacgccgcc gcgcatctcc aggtggccgg 9462 gggggtcccc gttgggcagg gagagggcgc tgacgatgca tcttatcaat tgccccgtag 9522 ggactccgcg caaggacctg agcgtctcga gatccacggg atctgaaaac cgttgaacga 9582 aggcttcgag ccagtcgcag tcgcaaggta ggctgagcac ggtttcttct ggcgggtcat 9642 gttggttgga gggagcgggg cgggcgatgc tgctggtgat gaagttgaaa taggcggttc 9702 tgagacggcg gatggtggcg aggagcacca ggtccttggg cccggcttgc tggatgcgca 9762 gacggtcggc catgccccag gcgtggtcct gacacctggc gaggtccttg tagtagtcct 9822 gcatgagccg ctccacgggc acctcctcct cgcccgcgcg gccgtgcatg cgcgtgagcc 9882 cgaacccgcg ctgcggctgg acgagcgcca ggtcggcgac gacgcgctcg gcgaggatgg 9942 cctgctggat ctgggtgagg gtggtctgga agtcgtcgaa gtcgacgaag cggtggtagg 10002 ctccggtgtt gatggtgtag gagcagttgg ccatgacgga ccagttgacg gtctggtggc 10062 ccggacgcac gagctcgtgg tacttgaggc gcgagtaggc gcgcgtgtcg aagatgtagt 10122 cgttgcaggt gcgcaccagg tactggtagc cgatgaggaa gtgcggcggc ggctggcggt 10182 agagcggcca tcgctcggtg gcgggggcgc cgggcgcgag gtcctcgagc atgaggcggt 10242 ggtagccgta gatgtacctg gacatccagg tgatgccggc ggcggtggtg gaggcgcgcg 10302 ggaactcgcg gacgcggttc cagatgttgc gcagcggcag gaagtagttc atggtgggca 10362 cggtctggcc cgtgaggcgc gcgcagtcgt ggatgctcta tacgggcaaa aacgaaagcg 10422 gtcagcggct cgactccgtg gcctggaggc taagcgaacg ggttgggctg cgcgtgtacc 10482 ccggttcgaa tctcgaatca ggctggagcc gcagctaacg tggtactggc actcccgtct 10542 cgacccaagc ctgcaccaac cctccaggat acggaggcgg gtcgttttgc aatttttttc 10602 ggaggccgga gactagtaag cgcggaaagc ggccgaccgc gatggctcgc tgccgtagtc 10662 tggagaagaa tcgccagggt tgcgttgcgg tgtgccccgg ttcgaggccg gccggattcc 10722 gcggctaacg agggcgtggc tgccccgtcg tttccaagac ccctagccag ccgacttctc 10782 cagttacgga gcgagcccct cttttgtttt ttgtttttgc cag atg cat ccc gta 10837 Met His Pro Val ctg cgg cag atg cgc ccc cac cac cct cca ccg caa caa cag ccc cct 10885 Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro 665 670 675 680 cca cag ccg gcg ctt ctg ccc ccg ccc cag cag caa ctt cca gcc acg 10933 Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Leu Pro Ala Thr 685 690 695 acc gcc gcg gcc gcc gtg agc ggg gct gga cag agt tat gac cac cag 10981 Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Ser Tyr Asp His Gln 700 705 710 ctg gcc ttg gaa gag ggc gag ggg ctg gcg cgc ctg ggg gcg tcg tcg 11029 Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser 715 720 725 ccg gag cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc 11077 Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala 730 735 740 tac gtg ccc aag cag aac ctg ttc aga gac agg agc ggc gag gag ccc 11125 Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro 745 750 755 760 gag gag atg cgc gcg gcc cgg ttc cac gcg ggg cgg gag ctg cgg cgc 11173 Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg 765 770 775 ggc ctg gac cga aag agg gtg ctg agg gac gag gat ttc gag gcg gac 11221 Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp 780 785 790 gag ctg acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac 11269 Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn 795 800 805 ctg gtc acg gcg tac gag cag acc gtg aag gag gag agc aac ttc caa 11317 Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln 810 815 820 aaa tcc ttc aac aac cac gtg cgc acg ctg atc gcg cgc gag gag gtg 11365 Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val 825 830 835 840 acc ctg ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc gtg cag 11413 Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln 845 850 855 aac ccc acg agc aag ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag 11461 Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln 860 865 870 cac agt cgg gac aac gag acg ttc agg gag gcg ctg ctg aat atc acc 11509 His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu Leu Asn Ile Thr 875 880 885 gag ccc gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg cag agc 11557 Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser 890 895 900 atc gtg gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc 11605 Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala 905 910 915 920 atc aac ttc tcg gtg ctg agt ttg ggc aag tac tac gct agg aag atc 11653 Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile 925 930 935 tac aag acc ccg tac gtg ccc ata gac aag gag gtg aag atc gac ggg 11701 Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly 940 945 950 ttt tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg 11749 Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu 955 960 965 ggg gtg tac cgc aac gac agg atg cac cgt gcg gtg agc gcc agc cgc 11797 Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg 970 975 980 cgg cgc gag ctg agc gac cag gag ctg atg cac agc ctg cag cgg gcc 11845 Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala 985 990 995 1000 ctg acc ggg gcc ggg acc gag ggg gag agc tac ttt gac atg ggc 11890 Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly 1005 1010 1015 gcg gac ctg cgc tgg cag ccc agc cgc cgg gcc ttg gaa gct gcc 11935 Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala 1020 1025 1030 ggc ggt tcc ccc tac gta gaa gag gtg gac gat gag gtg gac gag 11980 Gly Gly Ser Pro Tyr Val Glu Glu Val Asp Asp Glu Val Asp Glu 1035 1040 1045 gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag atg caa 12033 Glu Gly Glu Tyr Leu Glu Asp Met Gln 1050 caa cag cca cct cct gat ccc gcg atg cgg gcg gcg ctg cag agc 12078 Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser 1055 1060 1065 cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc atg 12123 Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 1070 1075 1080 caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa gcc ttt aga 12168 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 1085 1090 1095 cag cag ccc cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg 12213 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val 1100 1105 1110 gtg ccc tcg cgc tcc aac ccc acg cac gag aag gtc ctg gcc atc 12258 Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile 1115 1120 1125 gtg aac gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc 12303 Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala 1130 1135 1140 ggc ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc cgc tac aac 12348 Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn 1145 1150 1155 agc acc aac gtg cag acc aac ctg gac cgc atg gtg acc gac gtg 12393 Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val 1160 1165 1170 cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc gag tcc aac 12438 Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg Glu Ser Asn 1175 1180 1185 ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc acc cag ccc 12483 Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 1190 1195 1200 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc agc 12528 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser 1205 1210 1215 gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc gag gtg tac 12573 Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser Glu Val Tyr 1220 1225 1230 cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg 12618 Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu 1235 1240 1245 cag acc gtg aac ctg agc cag gct ttc aag aac ttg cag gga ttg 12663 Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu 1250 1255 1260 tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc 12708 Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser 1265 1270 1275 ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg gtg gcc ccc 12753 Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro 1280 1285 1290 ttc acg gac agc ggc agc atc aac cgc aac tcg tac ctg ggc tac 12798 Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly Tyr 1295 1300 1305 ctg att aac ctg tac cgc gag gcc atc ggc cag gcg cac gtg gac 12843 Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 1310 1315 1320 gag cag acc tac cag gag atc acc cac gtg agc cgc gcc ctg ggc 12888 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 1325 1330 1335 cag gac gac ccg ggc aac ctg gaa gcc acc ctg aac ttt ttg ctg 12933 Gln Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu 1340 1345 1350 acc aac cgg tcg cag aag atc ccg ccc cag tac gcg ctc agc acc 12978 Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr 1355 1360 1365 gag gag gag cgc atc ctg cgt tac gtg cag cag agc gtg ggc ctg 13023 Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu 1370 1375 1380 ttc ctg atg cag gag ggg gcc acc ccc agc gcc gcg ctc gac atg 13068 Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met 1385 1390 1395 acc gcg cgc aac atg gag ccc agc atg tac gcc agc aac cgc ccg 13113 Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro 1400 1405 1410 ttc atc aat aaa ctg atg gac tac ttg cat cgg gcg gcc gcc atg 13158 Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met 1415 1420 1425 aac tct gac tat ttc acc aac gcc atc ctg aat ccc cac tgg ctc 13203 Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu 1430 1435 1440 ccg ccg cct ggg ttc tac acg ggc gag tac gac atg ccc gac ccc 13248 Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro 1445 1450 1455 aat gac ggg ttc ctg tgg gac gat gtg gac agc agc gtg ttc tcc 13293 Asn Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser 1460 1465 1470 ccc cga ccg ggt gct aac gag cgc ccc ttg tgg aag aag gaa ggc 13338 Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu Trp Lys Lys Glu Gly 1475 1480 1485 agc gac cga cgc ccg tcc tcg gcg ctg tcc ggc cgc gag ggt gct 13383 Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Glu Gly Ala 1490 1495 1500 gcc gcg gcg gtg ccc gag gcc gcc agt cct ttt cct agc ttg ccc 13428 Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro 1505 1510 1515 ttc tcg ctg aac agt atc cgc agc agc gag ctg ggg agg atc acg 13473 Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr 1520 1525 1530 cgc ccg cgc ttg ctg ggc gag gag gag tac ttg aat gac tcg ctg 13518 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu 1535 1540 1545 ttg aga ccc gag cgg gag aag aac ttc ccc aat aac ggg ata gag 13563 Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 1550 1555 1560 agc ctg gtg gac aag atg agc cgc tgg aag acg tat gcg cag gag 13608 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu 1565 1570 1575 cac agg gac gat ccc cgg gcg tcg cag ggg gcc acg agc cgg ggc 13653 His Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Thr Ser Arg Gly 1580 1585 1590 agc gcc gcc cgt aaa cgc cgg tgg cac gac agg cag cgg gga ctg 13698 Ser Ala Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu 1595 1600 1605 atg tgg gac gat gag gat tcc gcc gac gac agc agc gtg ttg gac 13743 Met Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp 1610 1615 1620 ttg ggt ggg agt ggt ggt ggt aac ccg ttc gct cac ctg cgc ccc 13788 Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro 1625 1630 1635 cgc atc ggg cgc atg atg taagaaaccg aaaataaatg atactcacca 13836 Arg Ile Gly Arg Met Met 1640 1645 aggccatggc gaccagcgtg cgttcgtttc ttctctgttg ttgtatctag t atg atg 13893 Met Met agg cgt gcg tac ccg gag ggt cct cct ccc tcg tac gag agc gtg 13938 Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser Val 1650 1655 1660 atg cag cag gcg atg gcg gcg gcg gcg gcg atg cag ccc ccg ctg 13983 Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 1665 1670 1675 gag gct cct tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg 14028 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly 1680 1685 1690 cgg aac agc att cgt tac tcg gag ctg gca ccc ttg tac gat acc 14073 Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr 1695 1700 1705 acc cgg ttg tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg 14118 Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser 1710 1715 1720 ctg aac tac cag aac gac cac agc aac ttc ctg acc acc gtg gtg 14163 Leu Asn Tyr Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val 1725 1730 1735 cag aac aat gac ttc acc ccc acg gag gcc agc acc cag acc atc 14208 Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile 1740 1745 1750 aac ttt gac gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc 14253 Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile 1755 1760 1765 atg cac acc aac atg ccc aac gtg aac gag ttc atg tac agc aac 14298 Met His Thr Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn 1770 1775 1780 aag ttc aag gcg cgg gtc atg gtc tcc cgc aag acc ccc aac ggg 14343 Lys Phe Lys Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly 1785 1790 1795 gtg gga gag gat tat gat ggt agt cag gat gag ctg aaa tac gaa 14388 Val Gly Glu Asp Tyr Asp Gly Ser Gln Asp Glu Leu Lys Tyr Glu 1800 1805 1810 tgg gtg gag ttt gag ctg ccc gaa ggc aac ttc tcg gtg acc atg 14433 Trp Val Glu Phe Glu Leu Pro Glu Gly Asn Phe Ser Val Thr Met 1815 1820 1825 acc atc gac ctg atg aac aac gcc atc atc gac aat tac ttg gcg 14478 Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Ala 1830 1835 1840 gtg ggg cgg cag aac ggg gtc ctg gag agc gat atc ggc gtg aag 14523 Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys 1845 1850 1855 ttc gac act agg aac ttc agg ctg ggg tgg gac ccc gtg acc gag 14568 Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu 1860 1865 1870 ctg gtc atg ccc ggg gtg tac acc aac gag gcc ttc cat ccc gat 14613 Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp 1875 1880 1885 att gtc ttg ctg ccc ggc tgc ggg gtg gac ttc acc gag agc cgc 14658 Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 1890 1895 1900 ctc agc aac ctg ctg ggc att cgc aag agg cag cca ttc cag gag 14703 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 1905 1910 1915 ggt ttc cag atc atg tac gag gat ctg gag ggg ggc aac atc ccc 14748 Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro 1920 1925 1930 gcg ctc ctg gat gtc gac gcc tat gag aaa agc aag gag gaa gca 14793 Ala Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ala 1935 1940 1945 gca gct gag gca acc gca gcc gta gcc acc gcc tct acc gag gtc 14838 Ala Ala Glu Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val 1950 1955 1960 agg ggc gat aat ttt gca agc gcc gca gca gtg gca gcg gcc gag 14883 Arg Gly Asp Asn Phe Ala Ser Ala Ala Ala Val Ala Ala Ala Glu 1965 1970 1975 gcg gct gaa acc gaa agt aag ata gtc att cag ccg gtg gag aag 14928 Ala Ala Glu Thr Glu Ser Lys Ile Val Ile Gln Pro Val Glu Lys 1980 1985 1990 gat agc aag aac agg agc tac aac gta cta ccg gac aag ata aac 14973 Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu Pro Asp Lys Ile Asn 1995 2000 2005 acc gcc tac cgc agc tgg tac ctg gcc tac aac tat ggc gac ccc 15018 Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro 2010 2015 2020 gag aag ggc gtg cgc tcc tgg acg ctg ctc acc acc tcg gac gtc 15063 Glu Lys Gly Val Arg Ser Trp Thr Leu Leu Thr Thr Ser Asp Val 2025 2030 2035 acc tgc ggc gtg gag caa gtc tac tgg tcg ctg ccc gac atg atg 15108 Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu Pro Asp Met Met 2040 2045 2050 caa gac ccg gtc acc ttc cgc tcc acg cgt caa gtt agc aac tac 15153 Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr 2055 2060 2065 ccg gtg gtg ggc gcc gag ctc ctg ccc gtc tac tcc aag agc ttc 15198 Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe 2070 2075 2080 ttc aac gag cag gcc gtc tac tcg cag cag ctg cgc gcc ttc acc 15243 Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr 2085 2090 2095 tcg ctc acg cac gtc ttc aac cgc ttc ccc gag aac cag atc ctc 15288 Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu 2100 2105 2110 gtc cgc ccg ccc gcg ccc acc att acc acc gtc agt gaa aac gtt 15333 Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val 2115 2120 2125 cct gct ctc aca gat cac ggg acc ctg ccg ctg cgc agc agt atc 15378 Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile 2130 2135 2140 cgg gga gtc cag cgc gtg acc gtt act gac gcc aga cgc cgc acc 15423 Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr 2145 2150 2155 tgc ccc tac gtc tac aag gcc ctg ggc ata gtc gcg ccg cgc gtc 15468 Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val 2160 2165 2170 ctc tcg agc cgc acc ttc taaaaa atg tcc att ctc atc tcg ccc agt 15516 Leu Ser Ser Arg Thr Phe Met Ser Ile Leu Ile Ser Pro Ser 2175 2180 2185 aat aac acc ggt tgg ggc ctg cgc gcg ccc agc aag atg tac gga 15561 Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly 2190 2195 2200 ggc gct cgc caa cgc tcc acg caa cac ccc gtg cgc gtg cgc ggg 15606 Gly Ala Arg Gln Arg Ser Thr Gln His Pro Val Arg Val Arg Gly 2205 2210 2215 cac ttc cgc gct ccc tgg ggc gcc ctc aag ggc cgc gtg cgg tcg 15651 His Phe Arg Ala Pro Trp Gly Ala Leu Lys Gly Arg Val Arg Ser 2220 2225 2230 cgc acc acc gtc gac gac gtg atc gac cag gtg gtg gcc gac gcg 15696 Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val Val Ala Asp Ala 2235 2240 2245 cgc aac tac acc ccc gcc gcc gcg ccc gtc tcc acc gtg gac gcc 15741 Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr Val Asp Ala 2250 2255 2260 gtc atc gac agc gtg gtg gcc gac gcg cgc cgg tac gcc cgc gcc 15786 Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala 2265 2270 2275 aag agc cgg cgg cgg cgc atc gcc cgg cgg cac cgg agc acc ccc 15831 Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr Pro 2280 2285 2290 gcc atg cgc gcg gcg cga gcc ttg ctg cgc agg gcc agg cgc acg 15876 Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 2295 2300 2305 gga cgc agg gcc atg ctc agg gcg gcc aga cgc gcg gct tca ggc 15921 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly 2310 2315 2320 gcc agc gcc ggc agg acc cgg aga cgc gcg gcc acg gcg gcg gca 15966 Ala Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala 2325 2330 2335 gcg gcc atc gcc agc atg tcc cgc ccg cgg cga ggg aac gtg tac 16011 Ala Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr 2340 2345 2350 tgg gtg cgc gac gcc gcc acc ggt gtg cgc gtg ccc gtg cgc acc 16056 Trp Val Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr 2355 2360 2365 cgc ccc cct cgc act tgaagatgtt cacttcgcga tgttgatgtg tcccagcggc 16111 Arg Pro Pro Arg Thr 2370 gagg atg tcc aag cgc aaa ttc aag gaa gag atg ctc cag gtc atc 16157 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile 2375 2380 2385 gcg cct gag atc tac ggc ccc gcg gcg gcg gtg aag gag gaa aga 16202 Ala Pro Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg 2390 2395 2400 aag ccc cgc aaa atc aag cgg gtc aaa aag gac aaa aag gaa gaa 16247 Lys Pro Arg Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu 2405 2410 2415 gat gtg gac gat gtg gtg gag ttt gtg cgc gag ttc gcc ccc cgg 16292 Asp Val Asp Asp Val Val Glu Phe Val Arg Glu Phe Ala Pro Arg 2420 2425 2430 cgg cgc gtg cag tgg cgc ggg cgg aag gtg cag ccg gtg ctg aga 16337 Arg Arg Val Gln Trp Arg Gly Arg Lys Val Gln Pro Val Leu Arg 2435 2440 2445 ccc ggc acc acc gtg gtc ttc acg ccc ggc gag cgc tcc ggc acc 16382 Pro Gly Thr Thr Val Val Phe Thr Pro Gly Glu Arg Ser Gly Thr 2450 2455 2460 gct tcc aag cgc tcc tac gac gag gtg tac ggg gat gat gat att 16427 Ala Ser Lys Arg Ser Tyr Asp Glu Val Tyr Gly Asp Asp Asp Ile 2465 2470 2475 ctg gag cag gcg gcc gag cgc ctg ggc gag ttt gct tac ggc aag 16472 Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu Phe Ala Tyr Gly Lys 2480 2485 2490 cgc agc cgc tcc gcg ccg aag gaa gag gcg gtg tcc atc ccg ctg 16517 Arg Ser Arg Ser Ala Pro Lys Glu Glu Ala Val Ser Ile Pro Leu 2495 2500 2505 gac cac ggc aac ccc acg ccg agc ctc aag ccc gtg acc ctg cag 16562 Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val Thr Leu Gln 2510 2515 2520 cag gtg ctg ccg agc gcg gcg ccg cga agg ggg ttc aag cgc gag 16607 Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys Arg Glu 2525 2530 2535 ggc gag gat ctg tat ccc acc atg cag ctg atg gtg ccc aaa cgc 16652 Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys Arg 2540 2545 2550 cag aag ctg gaa gac gtg ctg gaa acc atg aag gtg gac ccg gac 16697 Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val Asp Pro Asp 2555 2560 2565 gtg cag ccc gag gtc aag gtg cgg ccc atc aag cag gtg gcc ccg 16742 Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro 2570 2575 2580 ggt ctg ggc gtg cag acc gtg gac atc aag atc ccc acg gag ccc 16787 Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 2585 2590 2595 atg gaa acg cag acc gag ccc atg atc aag ccc agt acc agc acc 16832 Met Glu Thr Gln Thr Glu Pro Met Ile Lys Pro Ser Thr Ser Thr 2600 2605 2610 atg gag gtg cag acg gat ccc tgg atg cca gcc gcc ccc acc agc 16877 Met Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Pro Thr Ser 2615 2620 2625 agc cga aga ccc cgg cgc aag tac ggc gcg gcc agc ctg ctg atg 16922 Ser Arg Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met 2630 2635 2640 ccc aac tac gcg ctg cat cct tcc atc atc ccc acg ccg ggc tac 16967 Pro Asn Tyr Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr 2645 2650 2655 cgc ggc acg cgc ttc tac cgc ggt cat aca acc agc tcc cgc cgc 17012 Arg Gly Thr Arg Phe Tyr Arg Gly His Thr Thr Ser Ser Arg Arg 2660 2665 2670 cgc aag acc acc act cgc cgc cgc cgt cgc cgc aca gcc gcc gct 17057 Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg Thr Ala Ala Ala 2675 2680 2685 gca acc acc ccc gcc gcc ctg gtg cgg aga gtg tac cgc cgc ggc 17102 Ala Thr Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg Arg Gly 2690 2695 2700 cgc gcg cct ctg acc ctg ccg cgc gcg cgc tac cac ccg agc atc 17147 Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile 2705 2710 2715 gcc att taaaactttc gcctgctttg cag atg gct ctc aca tgc cgc ctc 17197 Ala Ile Met Ala Leu Thr Cys Arg Leu 2720 cgc gtc ccc att acg ggc tac cga gga aga aaa ccg cgc cgt aga 17242 Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg 2725 2730 2735 agg ctg gcg ggg aac ggg atg cgt cgc cac cac cac cgg cgg cgg 17287 Arg Leu Ala Gly Asn Gly Met Arg Arg His His His Arg Arg Arg 2740 2745 2750 cgc gcc atc agc aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg 17332 Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu 2755 2760 2765 atc ccc atc atc gcc gcg gcg atc ggg gcg atc ccc ggc att gct 17377 Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala 2770 2775 2780 tcc gtg gcg gtg cag gcc tct cag cgc cac tgagacacac ttggaaacat 17427 Ser Val Ala Val Gln Ala Ser Gln Arg His 2785 2790 cttgtaataa acca atg gac tct gac gct cct ggt cct gtg atg tgt 17474 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys 2795 2800 2805 ttt cgt aga cag atg gaa gac atc aat ttt tcg tcc ctg gct ccg 17519 Phe Arg Arg Gln Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro 2810 2815 2820 cga cac ggc acg cgg ccg ttc atg ggc acc tgg agc gac atc ggc 17564 Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp Ser Asp Ile Gly 2825 2830 2835 acc agc caa ctg aac ggg ggc gcc ttc aat tgg agc agt ctc tgg 17609 Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp Ser Ser Leu Trp 2840 2845 2850 agc ggg ctt aag aat ttc ggg tcc acg ctt aaa acc tat ggc agc 17654 Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys Thr Tyr Gly Ser 2855 2860 2865 aag gcg tgg aac agc acc aca ggg cag gcg ctg agg gat aag ctg 17699 Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu Arg Asp Lys Leu 2870 2875 2880 aaa gag cag aac ttc cag cag aag gtg gtc gat ggg ctc gcc tcg 17744 Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp Gly Leu Ala Ser 2885 2890 2895 ggc atc aac ggg gtg gtg gac ctg gcc aac cag gcc gtg cag cgg 17789 Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln Ala Val Gln Arg 2900 2905 2910 cag atc aac agc cgc ctg gac ccg gtg ccg ccc gcc ggc tcc gtg 17834 Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala Gly Ser Val 2915 2920 2925 gag atg ccg cag gtg gag gag gag ctg cct ccc ctg gac aag cgg 17879 Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp Lys Arg 2930 2935 2940 ggc gag aag cga ccc cgc ccc gac gcg gag gag acg ctg ctg acg 17924 Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu Thr 2945 2950 2955 cac acg gac gag ccg ccc ccg tac gag gag gcg gtg aaa ctg ggt 17969 His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 2960 2965 2970 ctg ccc acc acg cgg ccc atc gcg ccc ctg gcc acc ggg gtg ctg 18014 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 2975 2980 2985 aaa ccc gaa agt aat aag ccc gcg acc ctg gac ttg cct cct ccc 18059 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro 2990 2995 3000 cag cct tct cgc ccc tcc aca gtg gct aag ccc ctg ccg ccg gtg 18104 Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val 3005 3010 3015 gcc gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc cct cat gcg 18149 Ala Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala 3020 3025 3030 aac tgg cag agc act ctg aac agc atc gtg ggt ctg gga gtg cag 18194 Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln 3035 3040 3045 agt gtg aag cgc cgc cgc tgc tat taaacctacc gtagcgctta acttgcttgt 18248 Ser Val Lys Arg Arg Arg Cys Tyr 3050 ctgtgtgtgt atgtattatg tcgccgccgc cgctgtccac cagaaggagg agtgaagagg 18308 cgcgtcgccg agttgcaag atg gcc acc cca tcg atg ctg ccc cag tgg 18357 Met Ala Thr Pro Ser Met Leu Pro Gln Trp 3055 3060 gcg tac atg cac atc gcc gga cag gac gct tcg gag tac ctg agt 18402 Ala Tyr Met His Ile Ala Gly Gln Asp Ala Ser Glu Tyr Leu Ser 3065 3070 3075 ccg ggt ctg gtg cag ttc gcc cgc gcc aca gac acc tac ttc agt 18447 Pro Gly Leu Val Gln Phe Ala Arg Ala Thr Asp Thr Tyr Phe Ser 3080 3085 3090 ctg ggg aac aag ttt agg aac ccc acg gtg gcg ccc acg cac gat 18492 Leu Gly Asn Lys Phe Arg Asn Pro Thr Val Ala Pro Thr His Asp 3095 3100 3105 gtg acc acc gac cgc agc cag cgg ctg acg ctg cgc ttc gtg ccc 18537 Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Val Pro 3110 3115 3120 gtg gac cgc gag gac aac acc tac tcg tac aaa gtg cgc tac acg 18582 Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr Lys Val Arg Tyr Thr 3125 3130 3135 ctg gcc gtg ggc gac aac cgc gtg ctg gac atg gcc agc acc tac 18627 Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met Ala Ser Thr Tyr 3140 3145 3150 ttt gac atc cgc ggc gtg ttg gac cgg ggc cct agc ttc aaa ccc 18672 Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser Phe Lys Pro 3155 3160 3165 tac tcc ggc acc gcc tac aac agc ctg gct ccc aag gga gcg ccc 18717 Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly Ala Pro 3170 3175 3180 aat tcc agc cag tgg gag caa aat gaa aac aat ggt caa ggt caa 18762 Asn Ser Ser Gln Trp Glu Gln Asn Glu Asn Asn Gly Gln Gly Gln 3185 3190 3195 gct aag aca cac acc tat ggt gtt gct gct atg ggc gga ctt gat 18807 Ala Lys Thr His Thr Tyr Gly Val Ala Ala Met Gly Gly Leu Asp 3200 3205 3210 att acg aaa gag ggt ctt caa att gga act gat gct agt aag gaa 18852 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Ala Ser Lys Glu 3215 3220 3225 gat gac aat gaa att tat gcc gat gaa aca tat cag ccc gag cct 18897 Asp Asp Asn Glu Ile Tyr Ala Asp Glu Thr Tyr Gln Pro Glu Pro 3230 3235 3240 caa ata gga gag gaa aat tgg caa gac act gaa aac ttt tat gga 18942 Gln Ile Gly Glu Glu Asn Trp Gln Asp Thr Glu Asn Phe Tyr Gly 3245 3250 3255 ggc aga gct ctt aaa aaa gat acc aag atg aag cca tgc tat ggc 18987 Gly Arg Ala Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly 3260 3265 3270 tca ttt gcc aga cct acc aat gtg aag gga ggg caa gcc aaa gtg 19032 Ser Phe Ala Arg Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Val 3275 3280 3285 aaa aca gaa gaa aat gtt cag tca ttc gac ata gat ctg gct ttc 19077 Lys Thr Glu Glu Asn Val Gln Ser Phe Asp Ile Asp Leu Ala Phe 3290 3295 3300 ttt gat att cca agc acc ggc aca ggg agc aat ggt aca aat gta 19122 Phe Asp Ile Pro Ser Thr Gly Thr Gly Ser Asn Gly Thr Asn Val 3305 3310 3315 aat gat aag cca gac atg gtc atg tac act gaa aat gtg aat ttg 19167 Asn Asp Lys Pro Asp Met Val Met Tyr Thr Glu Asn Val Asn Leu 3320 3325 3330 gag acg cca gat act cat att gtg tac aaa cct gga act tca gat 19212 Glu Thr Pro Asp Thr His Ile Val Tyr Lys Pro Gly Thr Ser Asp 3335 3340 3345 gac agc tct gaa gcc aac ttg tgc cag cag gcc atg cca aac aga 19257 Asp Ser Ser Glu Ala Asn Leu Cys Gln Gln Ala Met Pro Asn Arg 3350 3355 3360 cct aac tac att ggt ttc aga gac aat ttt att ggg ctc atg tac 19302 Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr 3365 3370 3375 tac aac agt act ggc aac atg ggt gta ctg gct ggt cag gcc tca 19347 Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser 3380 3385 3390 cag ctg aat gct gtg gtt gac ttg caa gac aga aac acc gag ctg 19392 Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu 3395 3400 3405 tcc tac cag ctc ttg ctt gac tct ctg ggc gac aga acc cgg tat 19437 Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr 3410 3415 3420 ttc agt atg tgg aat cag gcg gtg gac agt tat gat cct gat gtg 19482 Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val 3425 3430 3435 cgc att att gaa aac cac ggt gtg gaa gat gaa ctt ccc aac tat 19527 Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr 3440 3445 3450 tgc ttc cca ttg gat gga gct ggt act aat gct gtt tac cag ggt 19572 Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln Gly 3455 3460 3465 gtt aaa gaa aaa act ggc aat aat ggc gag tgg gaa gca gat acc 19617 Val Lys Glu Lys Thr Gly Asn Asn Gly Glu Trp Glu Ala Asp Thr 3470 3475 3480 aat gtt gcc tct cag aac cag ata tgc aag ggt aac atc tat gcc 19662 Asn Val Ala Ser Gln Asn Gln Ile Cys Lys Gly Asn Ile Tyr Ala 3485 3490 3495 atg gaa att aac ctc caa gcc aac ctg tgg aga agt ttc ctc tac 19707 Met Glu Ile Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr 3500 3505 3510 tcg aac gtg gcc ctg tac ctg ccc gat tct tac aag tac acg ccg 19752 Ser Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro 3515 3520 3525 gcc aac atc acc ctg ccc acc aac acc aac act tat gat tac atg 19797 Ala Asn Ile Thr Leu Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met 3530 3535 3540 aat ggg aga gtg gtg cct ccc tcg ctg gtg gac gcc tac atc aac 19842 Asn Gly Arg Val Val Pro Pro Ser Leu Val Asp Ala Tyr Ile Asn 3545 3550 3555 atc ggg gcg cgc tgg tcg ctg gac ccc atg gac aac gtg aac ccc 19887 Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val Asn Pro 3560 3565 3570 ttc aac cac cac cgc aat gcg ggg ctg cgc tac cgc tcc atg ctc 19932 Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser Met Leu 3575 3580 3585 ctg ggc aac ggg cgc tac gtg ccc ttc cac atc cag gtg ccc cag 19977 Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro Gln 3590 3595 3600 aaa ttt ttc gcc atc aag agc ctc ctg ctc ctg ccc ggg tcc tac 20022 Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr 3605 3610 3615 acc tac gag tgg aac ttc cgc aag gac gtc aac atg atc ctg cag 20067 Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln 3620 3625 3630 agc tcc ctc ggc aac gac ctg cgc acg gac ggg gcc tcc atc tcc 20112 Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser 3635 3640 3645 ttc acc agc atc aac ctc tac gcc acc ttc ttc ccc atg gcg cac 20157 Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His 3650 3655 3660 aac acg gcc tcc acg ctc gag gcc atg ctg cgc aac gac acc aac 20202 Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn 3665 3670 3675 gac cag tcc ttc aac gac tac ctc tcg gcg gcc aac atg ctc tac 20247 Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr 3680 3685 3690 ccc atc ccg gcc aac gcc acc aac gtg ccc atc tcc atc ccc tcg 20292 Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser 3695 3700 3705 cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc acg cgt ctc aag 20337 Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys 3710 3715 3720 acc aag gag acg ccc tcg ctg ggc tcc ggg ttc gac ccc tac ttc 20382 Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe 3725 3730 3735 gtc tac tcg ggc tcc atc ccc tac ctc gac ggc acc ttc tac ctc 20427 Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu 3740 3745 3750 aac cac acc ttc aag aag gtc tcc atc acc ttc gac tcc tcc gtc 20472 Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val 3755 3760 3765 agc tgg ccc ggc aac gac cgg ctc ctg aca ccc aac gag ttc gaa 20517 Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu 3770 3775 3780 atc aag cgc acc gtc gac ggc gag ggc tac aac gtg gcc cag tgc 20562 Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala Gln Cys 3785 3790 3795 aac atg acc aag gac tgg ttc ctg gtc cag atg ctg gcc cac tac 20607 Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala His Tyr 3800 3805 3810 aac atc ggc tac cag ggc ttc tac gtg ccc gag ggc tac aag gac 20652 Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr Lys Asp 3815 3820 3825 cgc atg tac tcc ttc ttc cgc aac ttc cag ccc atg agc cgc cag 20697 Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg Gln 3830 3835 3840 gtg gtg gac gag gtc aac tac aag gac tac cag gcc gtc acc ctg 20742 Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu 3845 3850 3855 gcc tac cag cac aac aac tcg ggc ttc gtc ggc tac ctc gcg ccc 20787 Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro 3860 3865 3870 acc atg cgc cag ggg cag ccc tac ccc gcc aac tac ccg tac ccg 20832 Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro 3875 3880 3885 ctc atc ggc aag agc gcc gtc acc agc gtc acc cag aaa aag ttc 20877 Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys Phe 3890 3895 3900 ctc tgc gac agg gtc atg tgg cgc atc ccc ttc tcc agc aac ttc 20922 Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe 3905 3910 3915 atg tcc atg ggc gcg ctc acc gac ctc ggc cag aac atg ctc tat 20967 Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr 3920 3925 3930 gcc aac tcc gcc cac gcg cta gac atg aat ttc gaa gtc gac ccc 21012 Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val Asp Pro 3935 3940 3945 atg gat gag tcc acc ctt ctc tat gtt gtc ttc gaa gtc ttc gac 21057 Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe Asp 3950 3955 3960 gtc gtc cga gtg cac cag ccc cac cgc ggc gtc atc gag gcc gtc 21102 Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala Val 3965 3970 3975 tac ctg cgc acc ccc ttc tcg gcc ggt aac gcc acc acc taagctcttg 21151 Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 3980 3985 3990 cttcttgc atg atg gct gag ccc acg ggc tcc ggc gag cag gag ctc 21198 Met Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu 3995 4000 agg gcc atc atc cgc gac ctg ggc tgc ggg ccc tac ttc ctg ggc 21243 Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly 4005 4010 4015 acc ttc gat aag cgc ttc ccg gga ttc atg gcc ccg cac aag ctg 21288 Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu 4020 4025 4030 gcc tgc gcc atc gtc aac acg gcc ggt cgc gag acc ggg ggc gag 21333 Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu 4035 4040 4045 cac tgg ctg gcc ttc gcc tgg aac ccg cgc tcg aac acc tgc tac 21378 His Trp Leu Ala Phe Ala Trp Asn Pro Arg Ser Asn Thr Cys Tyr 4050 4055 4060 ctc ttc gac ccc ttc ggg ttc tcg gac gag cgc ctc aag cag atc 21423 Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg Leu Lys Gln Ile 4065 4070 4075 tac cag ttc gag tac gag ggc ctg ctg cgc cgc agc gcc ctg gcc 21468 Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg Ser Ala Leu Ala 4080 4085 4090 acc gag gac cgc tgc gtc acc ctg gaa aag tcc acc cag acc gtg 21513 Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser Thr Gln Thr Val 4095 4100 4105 cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttc tgc tgc atg ttc 21558 Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe Cys Cys Met Phe 4110 4115 4120 ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc atg gac aag aac 21603 Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met Asp Lys Asn 4125 4130 4135 ccc acc atg aac ttg ctg acg ggg gtg ccc aac ggc atg ctc cag 21648 Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met Leu Gln 4140 4145 4150 tcg ccc cag gtg gaa ccc acc ctg cgc cgc aac cag gag gcg ctc 21693 Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala Leu 4155 4160 4165 tac cgc ttc ctc aac gcc cac tcc gcc tac ttt cgc tcc cac cgc 21738 Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 4170 4175 4180 gcg cgc atc gag aag gcc acc gcc ttc gac cgc atg aat caa gac 21783 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp 4185 4190 4195 atg taaaccgtgt gtgtatgtga atgctttatt cataataaac agcacatgtt 21836 Met 4200 tatgccacct tctctgaggc tctgacttta tttagaaatc gaaggggttc tgccggctct 21896 cggcgtgccc cgcgggcagg gatacgttgc ggaactggta cttgggcagc cacttgaact 21956 cggggatcag cagcttcggc acggggaggt cggggaacga gtcgctccac agcttgcgcg 22016 tgagttgcag ggcgcccagc aggtcgggcg cggagatctt gaaatcgcag ttgggacccg 22076 cgttctgcgc gcgagagttg cggtacacgg ggttgcagca ctggaacacc atcagggccg 22136 ggtgcttcac gctcgccagc accgtcgcgt cggtgatgcc ctccacgtcc agatcctcgg 22196 cgttggccat cccgaagggg gtcatcttgc aggtctgccg ccccatgctg ggcacgcagc 22256 cgggcttgtg gttgcaatcg cagtgcaggg ggatcagcat catctgggcc tgctcggagc 22316 tcatgcccgg gtacatggcc ttcatgaaag cctccagctg gcggaaggcc tgctgcgcct 22376 tgccgccctc ggtgaagaag accccgcagg acttgctaga gaactggttg gtagcgcagc 22436 ccgcgtcgtg cacgcagcag cgcgcgtcgt tgttggccag ctgcaccacg ctgcgccccc 22496 agcggttctg ggtgatcttg gcccggtcgg ggttctcctt cagcgcgcgc tgcccgttct 22556 cgctcgccac atccatctcg atcgtgtgct ccttctggat catcacggtc ccgtgcaggc 22616 accgcagctt gccctcggcc tcggtgcagc cgtgcagcca cagcgcgcag ccggtgctct 22676 cccagttctt gtgggcgatc tgggagtgcg agtgcacgaa gccctgcagg aagcggccca 22736 tcatcgtggt cagggtcttg ttgctggtga aggtcagcgg gatgccgcgg tgctcctcgt 22796 tcacatacag gtggcagatg cggcggtaca cctcgccctg ctcgggcatc agctggaagg 22856 cggacttcag gtcgctctcc acgcggtacc gctccatcag cagcgtcatc acttccatgc 22916 ccttctccca ggccgaaacg atcggcaggc tcagggggtt cttcaccgtc atcttagtcg 22976 ccgccgccga ggtcaggggg tcgttctcgt ccagggtctc aaacactcgc ttgccgtcct 23036 tctcggtgat gcgcacgggg gggaaggcga agcccacggc cgccagctcc tcctcggcct 23096 gcctttcgtc ctcgctgtcc tggctgatgt cttgcaaagg cacatgcttg gtcttgcggg 23156 gtttcttttt gggcggcaga ggcggcggcg gagacgtgct gggcgagcgc gagttctcgc 23216 tcaccacgac tatttcttct ccttggccgt cgtccgagac cacgcggcgg taggcatgcc 23276 tcttctgggg cagaggcgga ggcgacgggc tctcgcggtt cggcgggcgg ctggcagagc 23336 cccttccgcg ttcgggggtg cgctcctggc ggcgctgctc tgactgactt cctccgcggc 23396 cggccattgt gttctcctag ggagcaagc atg gag act cag cca tcg tcg cca 23449 Met Glu Thr Gln Pro Ser Ser Pro 4205 aca tcg cca tct gcc ccc gcc tcc acc gcc gac gag aac cag cag 23494 Thr Ser Pro Ser Ala Pro Ala Ser Thr Ala Asp Glu Asn Gln Gln 4210 4215 4220 cag cag aat gaa agc tta acc gcc ccg ccg ccc agc ccc acc tcc 23539 Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro Thr Ser 4225 4230 4235 gac gcc gcg gcc cca gac atg caa gag atg gag gaa tcc atc gag 23584 Asp Ala Ala Ala Pro Asp Met Gln Glu Met Glu Glu Ser Ile Glu 4240 4245 4250 att gac ctg ggc tac gtg acg ccc gcg gag cac gag gag gag ctg 23629 Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu Glu Leu 4255 4260 4265 gca gcg cgc ttt tca gcc ccg gaa gaa aac cac caa gag cag cca 23674 Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln Pro 4270 4275 4280 gag cag gaa gca gag aac gag cag aac cag gct ggg ctc gag cat 23719 Glu Gln Glu Ala Glu Asn Glu Gln Asn Gln Ala Gly Leu Glu His 4285 4290 4295 ggc gac tac ctg agc ggg gca gag gac gtg ctc atc aag cat ctg 23764 Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu 4300 4305 4310 gcc cgc caa tgc atc atc gtc aag gac gcg ctg ctc gac cgc gcc 23809 Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 4315 4320 4325 gag gtg ccc ctc agc gtg gcg gag ctc agc cgc gcc tac gag cgc 23854 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg 4330 4335 4340 aac ctc ttc tcg cca cgc gtg ccc ccc aag cgc cag ccc aac ggc 23899 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly 4345 4350 4355 acc tgc gag ccc aac ccg cgc ctc aac ttc tac ccg gtc ttc gcg 23944 Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala 4360 4365 4370 gtg ccc gag gcc ctg gcc acc tac cac ctc ttt ttc aag aac caa 23989 Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln 4375 4380 4385 agg atc ccc gtc tcc tgc cgc gcc aac cgc acc cgc gcc gac gcc 24034 Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala 4390 4395 4400 ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct gat atc gcc tcc 24079 Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser 4405 4410 4415 ttg gaa gag gtt ccc aag atc ttc gag ggt ctg ggc agc gac gag 24124 Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu 4420 4425 4430 act cgg gcc gcg aac gct ctg caa gga agc gga gag gag cat gag 24169 Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly Glu Glu His Glu 4435 4440 4445 cac cac agc gcc ctg gtg gag ttg gaa ggc gac aac gcg cgc ctg 24214 His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg Leu 4450 4455 4460 gcg gtc ctc aag cgc acg gtc gag ctg acc cac ttc gcc tac cca 24259 Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr Pro 4465 4470 4475 gcg ctc aac ctg ccc ccc aag gtc atg agc gcc gtc atg gac cag 24304 Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala Val Met Asp Gln 4480 4485 4490 gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag gag gag atg cag 24349 Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu Met Gln 4495 4500 4505 gac ccc gag agc tcg gac gag ggc aag ccc gtg gtc agc gac gag 24394 Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp Glu 4510 4515 4520 cag ctg gcg cgc tgg ctg gga gcg agt agc acc ccc cag agc ctg 24439 Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln Ser Leu 4525 4530 4535 gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg gtg acc gtg 24484 Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val 4540 4545 4550 gag ctg gag tgt ctg cgc cgc ttc ttt gcc gac gcg gag acc ctg 24529 Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 4555 4560 4565 cgc aag gtc gag gag aac ctg cac tac ctc ttc agg cac ggg ttc 24574 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe 4570 4575 4580 gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg acc aac ctg 24619 Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu 4585 4590 4595 gtc tcc tac atg ggc atc ctg cac gag aac cgc ctg ggg cag aac 24664 Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn 4600 4605 4610 gtg ctg cac acc acc ctg cgc ggg gag gcc cgc cgc gac tac atc 24709 Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile 4615 4620 4625 cgc gac tgc gtc tac ctg tac ctc tgc cac acc tgg cag acg ggc 24754 Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly 4630 4635 4640 atg ggc gtg tgg cag cag tgc ctg gag gag cag aac ctg aaa gag 24799 Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu 4645 4650 4655 ctc tgc aag ctc ctg cag aag aac ctc aag gcc ctg tgg acc ggg 24844 Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu Trp Thr Gly 4660 4665 4670 ttc gac gag cgc acc acc gcc tcg gac ctg gcc gac ctc atc ttc 24889 Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile Phe 4675 4680 4685 ccc gag cgc ctg cgg ctg acg ctg cgc aac ggg ctg ccc gac ttt 24934 Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp Phe 4690 4695 4700 atg agc caa agc atg ttg caa aac ttt cgc tct ttc atc ctc gaa 24979 Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile Leu Glu 4705 4710 4715 cgc tcc ggg atc ctg ccc gcc acc tgc tcc gcg ctg ccc tcg gac 25024 Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser Asp 4720 4725 4730 ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg ccg ctc tgg agc 25069 Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp Ser 4735 4740 4745 cac tgc tac ctg ctg cgc ctg gcc aac tac ctg gcc tac cac tcg 25114 His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His Ser 4750 4755 4760 gac gtg atc gag gac gtc agc ggc gag ggt ctg ctc gag tgc cac 25159 Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His 4765 4770 4775 tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc ctg gcc tgc aac 25204 Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn 4780 4785 4790 ccc cag ctg ctg agc gag acc cag atc atc ggc acc ttc gag ttg 25249 Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 4795 4800 4805 caa ggc ccc ggc gac agc gag ggc aag ggg ggt ctg aaa ctc acc 25294 Gln Gly Pro Gly Asp Ser Glu Gly Lys Gly Gly Leu Lys Leu Thr 4810 4815 4820 ccg ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag 25339 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu 4825 4830 4835 gac tac cat ccc ttc gag atc agg ttc tac gag gac caa tcc cag 25384 Asp Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln 4840 4845 4850 ccg ccc aag gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcc 25429 Pro Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala 4855 4860 4865 atc ctg gcc caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttt 25474 Ile Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe 4870 4875 4880 ctg ctg aaa aag ggc cac ggg gtc tac ttg gac ccc cag acc gga 25519 Leu Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln Thr Gly 4885 4890 4895 gag gag ctc aac ccc agc ttc ccc cag gat gcc ccg agg aag cag 25564 Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Pro Arg Lys Gln 4900 4905 4910 caa gaa gct gaa agt gga gct gcc gcc gga gga ttt gga gga aga 25609 Gln Glu Ala Glu Ser Gly Ala Ala Ala Gly Gly Phe Gly Gly Arg 4915 4920 4925 ctg gga gag cag tca ggc aga gga gga gat gga aga ctg gga cag 25654 Leu Gly Glu Gln Ser Gly Arg Gly Gly Asp Gly Arg Leu Gly Gln 4930 4935 4940 cac tca ggc aga gga gga cag cct gca aga cag tct gga gga gga 25699 His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Gly 4945 4950 4955 aga cga ggt gga gga gga ggc aga gga aga agc agc cgc cgc cag 25744 Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln 4960 4965 4970 acc gtc gtc ctc ggc gga gga gaa agc aag cag cac gga tac cat 25789 Thr Val Val Leu Gly Gly Gly Glu Ser Lys Gln His Gly Tyr His 4975 4980 4985 ctc cgc tcc ggg tcg ggg tcg cgg cgg ccg ggc cca cag tagatgggac 25838 Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 4990 4995 5000 gagaccgggc gcttcccgaa ccccaccacc cagaccggta agaaggagcg gcagggatac 25898 aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg cgggggcaac 25958 atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc 26018 ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga ggcagaaacc 26078 cagcagcagc agaaaaccag cggcagcagc agctagaaaa tccacagcgg cggcaggtgg 26138 actgaggatc gcggcgaacg agccggcgca gacccgggag ctgaggaacc ggatctttcc 26198 caccctctat gccatcttcc agcagagtcg ggggcaggag caggaactga aagtcaagaa 26258 ccgttctctg cgctcgctca cccgcagttg tctgtatcac aagagcgaag accaacttca 26318 gcgcactctc gaggacgccg aggctctctt caacaagtac tgcgcgctca ctcttaaaga 26378 gtagcccgcg cccgcccaca cacggaaaaa ggcgggaatt acgtcaccac ctgcgccctt 26438 cgcccgacca tc atg agc aaa gag att ccc acg cct tac atg tgg agc 26486 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser 5005 5010 tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc cag gac tac 26531 Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr 5015 5020 5025 tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg atg atc tca 26576 Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile Ser 5030 5035 5040 cgg gtg aat gac atc cgc gcc cgc cga aac cag ata ctc cta gaa 26621 Arg Val Asn Asp Ile Arg Ala Arg Arg Asn Gln Ile Leu Leu Glu 5045 5050 5055 cag tca gcg atc acc gcc acg ccc cgc cat cac ctt aat ccg cgt 26666 Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu Asn Pro Arg 5060 5065 5070 aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc cag ccc acg 26711 Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr 5075 5080 5085 acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc cag ctg act 26756 Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu Thr 5090 5095 5100 aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg tgt cgt cac 26801 Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu Cys Arg His 5105 5110 5115 cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga ggc aga ggc 26846 Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg Gly 5120 5125 5130 aca cag ctc aac gac gag gtg gtg agc tct tcg ctg ggt ctg cga 26891 Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu Arg 5135 5140 5145 cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga tct tcc ttc 26936 Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser Phe 5150 5155 5160 acg cct cgt cag gcc gtc ctg act ttg gag agt tcg tcc tcg cag 26981 Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser Gln 5165 5170 5175 ccc cgc tcg ggc ggc atc ggc act ctc cag ttc gtg gag gag ttc 27026 Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 5180 5185 5190 act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc cac 27071 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His 5195 5200 5205 tac ccg gac gag ttc atc ccg aac ttc gac gcc atc agc gag tcg 27116 Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser 5210 5215 5220 gtg gac ggc tac gat tgaatgtccc atggtggcgc agctgaccta gctcggcttc 27171 Val Asp Gly Tyr Asp 5225 gacacctgga ccactgccgc cgcttccgct gcttcgctcg ggatctcgcc gagtttgcct 27231 actttgagct gcccgaggag caccctcagg gcccagccca cggagtgcgg atcatcgtcg 27291 aagggggcct cgactcccac ctgcttcgga tcttcagcca gcgaccgatc ctggtcgagc 27351 gcgaacaagg acagacccgt ctgaccctgt actgcatctg caaccacccc ggcctgc 27408 atg aaa gtc ttt gtt gtc tgc tgt gta ctg agt ata ata aaa gct 27453 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala 5230 5235 5240 gag atc agc gac tac tcc gga ctc gat tgt ggt gtt cct gct atc 27498 Glu Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile 5245 5250 5255 aac cgg tcc ctg ttc ttc acc ggg aac gaa acc gag ctc cag ctc 27543 Asn Arg Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu 5260 5265 5270 cag tgt aag ccc cac aag aag tac ctc acc tgg ctg ttc cag ggc 27588 Gln Cys Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly 5275 5280 5285 tcc ccc atc gcc gtt gtc aac cac tgc gac aac gac gga gtc ctg 27633 Ser Pro Ile Ala Val Val Asn His Cys Asp Asn Asp Gly Val Leu 5290 5295 5300 ctg agc ggc cct gcc aac ctt act ttt tcc acc cgc aga agc aag 27678 Leu Ser Gly Pro Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys 5305 5310 5315 ctc cag ctc ttc caa ccc ttc ctc ccc ggg acc tat cag tgc gtc 27723 Leu Gln Leu Phe Gln Pro Phe Leu Pro Gly Thr Tyr Gln Cys Val 5320 5325 5330 tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg aat acc aca 27768 Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro Asn Thr Thr 5335 5340 5345 gcg ccg ctc ccc gct act aac aac caa act aac ctc cac caa cgc 27813 Ala Pro Leu Pro Ala Thr Asn Asn Gln Thr Asn Leu His Gln Arg 5350 5355 5360 cac cgt cgc gac ctt tcc tct gaa tct aat acc act acc gga ggt 27858 His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr Gly Gly 5365 5370 5375 gag ctc cga ggt cga cca acc tct ggg att tac tac ggc ccc tgg 27903 Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly Pro Trp 5380 5385 5390 gag gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt ggg ctt 27948 Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly Leu 5395 5400 5405 ttg gct ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta gtg 27993 Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val 5410 5415 5420 gtg ctg tgt tgc tgg ttt aag aaa tgg ggc aga tca ccc tagtgagctg 28042 Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 5425 5430 5435 cggtgtgctg gtggcggtgc tttcgattgt gggactgggc ggcgcggctg tagtgaagga 28102 ggagaaggcc gatccctgct tgcatttcaa tcccgacaaa tgccagctga gttttcagcc 28162 cgatggcaat cggtgcgcgg tgctgatcaa gtgcggatgg gaatgcgaga acgtgagaat 28222 cgagtacaat aacaagactc ggaacaatac tctcgcgtcc gtgtggcagc ccggggaccc 28282 cgagtggtac accgtctctg tccccggtgc tgacggctcc ccgcgcaccg tgaataatac 28342 tttcattttt gcgcacatgt gcaacacggt catgtggatg agcaagcagt acgatatgtg 28402 gccccccacg aaggagaaca tcgtggtctt ctccatcgct tacagcctgt gcacggcgct 28462 aatcaccgct atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa 28522 tgccgagaaa gagaaacagc cataacacgt tttttcacac accttgtttt tacagaca 28580 atg cgt ctg tta aat ttt tta aac att gtg ctc agt att gct tat 28625 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr 5440 5445 5450 gcc tct ggt tat gca aac ata cag aaa acc ctt tat gta gga tct 28670 Ala Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser 5455 5460 5465 gat ggt aca cta gag ggt acc caa tca caa gcc aag gtt gca tgg 28715 Asp Gly Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp 5470 5475 5480 tat ttt tat aga acc aac act gat cca gtt aaa ctt tgt aag ggt 28760 Tyr Phe Tyr Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly 5485 5490 5495 gaa ttg ccg cgt aca cat aaa act cca ctt aca ttt agt tgc agc 28805 Glu Leu Pro Arg Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser 5500 5505 5510 aat aat aat ctt aca ctt ttt tca att aca aaa caa tat act ggt 28850 Asn Asn Asn Leu Thr Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly 5515 5520 5525 act tat tac agt aca aac ttt cat aca gga caa gat aaa tat tat 28895 Thr Tyr Tyr Ser Thr Asn Phe His Thr Gly Gln Asp Lys Tyr Tyr 5530 5535 5540 act gtt aag gta gaa aat cct acc act cct aga act acc acc acc 28940 Thr Val Lys Val Glu Asn Pro Thr Thr Pro Arg Thr Thr Thr Thr 5545 5550 5555 acc acc act act gca aag ccc act gtg aaa act aca act agg acc 28985 Thr Thr Thr Thr Ala Lys Pro Thr Val Lys Thr Thr Thr Arg Thr 5560 5565 5570 acc aca act aca gaa acc acc acc agc aca aca ctt gct gca act 29030 Thr Thr Thr Thr Glu Thr Thr Thr Ser Thr Thr Leu Ala Ala Thr 5575 5580 5585 aca cac aca cac act aag cta acc tta cag acc act aat gat ttg 29075 Thr His Thr His Thr Lys Leu Thr Leu Gln Thr Thr Asn Asp Leu 5590 5595 5600 atc gcc ctg ctg caa aag ggg gat aac agc acc act tcc aat gag 29120 Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr Thr Ser Asn Glu 5605 5610 5615 gag ata ccc aaa tcc atg att ggc att att gtt gct gta gtg gtg 29165 Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val Val Val 5620 5625 5630 tgc atg ttg atc atc gcc ttg tgc atg gtg tac tat gcc ttc tgc 29210 Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys 5635 5640 5645 tac aga aag cac aga ctg aac gac aag ctg gaa cac tta cta agt 29255 Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser 5650 5655 5660 gtt gaa ttt taatttttta gaacc atg aag atc cta ggc ctt ttt agt 29303 Val Glu Phe Met Lys Ile Leu Gly Leu Phe Ser 5665 5670 ttt tct atc att acc tct gct ctt tgt gaa tca gtg gat aga gat 29348 Phe Ser Ile Ile Thr Ser Ala Leu Cys Glu Ser Val Asp Arg Asp 5675 5680 5685 gtt act att acc act ggt tct aat tat aca ctg aaa ggg cca ccc 29393 Val Thr Ile Thr Thr Gly Ser Asn Tyr Thr Leu Lys Gly Pro Pro 5690 5695 5700 tca ggt atg ctt tcg tgg tat tgc tat ttt gga act gac act gat 29438 Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe Gly Thr Asp Thr Asp 5705 5710 5715 caa act gaa tta tgc aat ttt caa aaa ggc aaa acc tca aac tct 29483 Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys Thr Ser Asn Ser 5720 5725 5730 aaa atc tct aat tat caa tgc aat ggc act gat ctg ata cta ctc 29528 Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu Ile Leu Leu 5735 5740 5745 aat gtc acg aaa gca tat ggt ggc agt tat tat tgc cct gga caa 29573 Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro Gly Gln 5750 5755 5760 aac act gaa gaa atg att ttt tac aaa gtg gaa gtg gtt gat ccc 29618 Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp Pro 5765 5770 5775 act aca cca ccc acc acc aca act att cat acc aca cac aca gaa 29663 Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu 5780 5785 5790 caa aca cca gag gca aca gaa gca gag ttg gcc ttc cag gtt cac 29708 Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His 5795 5800 5805 gga gat tcc ttt gct gtc aat acc cct aca ccc gat cag cgg tgt 29753 Gly Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys 5810 5815 5820 ccg ggg ccg cta gtc agc ggc att gtc ggt gtg ctt tcg gga tta 29798 Pro Gly Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu 5825 5830 5835 gca gtc ata atc atc tgc atg ttc att ttt gct tgc tgc tat aga 29843 Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg 5840 5845 5850 agg ctt tac cga caa aaa tca gac cca ctg ctg aac ctc tat gtt 29888 Arg Leu Tyr Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 5855 5860 5865 taattttttc cagagcc atg aag gca gtt agc gct cta gtt ttt tgt tct 29938 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser 5870 5875 ttg att ggc att gtt ttt aat agt aaa att acc aaa gtt agc ttt 29983 Leu Ile Gly Ile Val Phe Asn Ser Lys Ile Thr Lys Val Ser Phe 5880 5885 5890 att aaa cat gtt aat gta act gaa gga gat aac atc aca cta gca 30028 Ile Lys His Val Asn Val Thr Glu Gly Asp Asn Ile Thr Leu Ala 5895 5900 5905 ggt gta gaa ggt gct caa aac acc acc tgg aca aaa tac cat cta 30073 Gly Val Glu Gly Ala Gln Asn Thr Thr Trp Thr Lys Tyr His Leu 5910 5915 5920 gga tgg aga gat att tgc acc tgg aat gta act tat tat tgc ata 30118 Gly Trp Arg Asp Ile Cys Thr Trp Asn Val Thr Tyr Tyr Cys Ile 5925 5930 5935 gga att aat ctt acc att gtt aac gct aac caa tct cag aat ggg 30163 Gly Ile Asn Leu Thr Ile Val Asn Ala Asn Gln Ser Gln Asn Gly 5940 5945 5950 tta att aaa gga cag agt gtt agt gtg acc agt gat ggg tac tat 30208 Leu Ile Lys Gly Gln Ser Val Ser Val Thr Ser Asp Gly Tyr Tyr 5955 5960 5965 acc cag cat agt ttt aac tac aac att act gtc ata cca ctg cct 30253 Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val Ile Pro Leu Pro 5970 5975 5980 acg cct agc cca cct agc act acc aca cag aca acc aca tac agt 30298 Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr Thr Tyr Ser 5985 5990 5995 aca tca aat cag cct acc acc act aca gca gca gag gtt gcc agc 30343 Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala Ser 6000 6005 6010 tcg tct ggg gtc cga gtg gca ttt ttg atg ttg gcc cca tct agc 30388 Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser Ser 6015 6020 6025 agt ccc act gct agt acc aat gag cag act act gaa ttt ttg tcc 30433 Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 6030 6035 6040 act gtc gag agc cac acc aca gct acc tcc agt gcc ttc tct agc 30478 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser 6045 6050 6055 acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc agc ccc gct 30523 Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala 6060 6065 6070 act act cct agc ccc gct cct ctt ccc act ccc ctg aag caa aca 30568 Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr 6075 6080 6085 gac ggc ggc atg caa tgg cag atc acc ctg ctc att gtg atc ggg 30613 Asp Gly Gly Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly 6090 6095 6100 ttg gtc atc ctg gcc gtg ttg ctc tac tac atc ttc tgc cgc cgc 30658 Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg 6105 6110 6115 att ccc aac gcg cac cgc aag ccg gcc tac aag ccc atc gtt atc 30703 Ile Pro Asn Ala His Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile 6120 6125 6130 ggg cag ccg gag ccg ctt cag gtg gaa ggg ggt cta agg aat ctt 30748 Gly Gln Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu 6135 6140 6145 ctc ttc tct ttt aca gta tgg tgattgaact atg att cct aga caa ttc 30797 Leu Phe Ser Phe Thr Val Trp Met Ile Pro Arg Gln Phe 6150 6155 6160 ttg atc act att ctt atc tgc ctc ctc caa gtc tgt gcc acc ctc 30842 Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln Val Cys Ala Thr Leu 6165 6170 6175 gct ctg gtg gcc aac gcc agt cca gac tgt att ggg ccc ttc gcc 30887 Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile Gly Pro Phe Ala 6180 6185 6190 tcc tac gtg ctc ttt gcc ttc atc acc tgc atc tgc tgc tgt agc 30932 Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys Cys Cys Ser 6195 6200 6205 ata gtc tgc ctg ctt atc acc ttc ttc cag ttc att gac tgg atc 30977 Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp Trp Ile 6210 6215 6220 ttt gtg cgc atc gcc tac ctg cgc cac cac ccc cag tac cgc gac 31022 Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg Asp 6225 6230 6235 cag cga gtg gcg cag ctg ctc agg ctc ctc tgataagc atg cgg gct 31069 Gln Arg Val Ala Gln Leu Leu Arg Leu Leu Met Arg Ala 6240 6245 ctg cta ctt ctc gcg ctt ctg ctg tta gtg ctc ccc cgt ccc gtt 31114 Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg Pro Val 6250 6255 6260 gac ccc cgg ccc ccc act cag tcc ccc gag gag gtc cgc aaa tgc 31159 Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys Cys 6265 6270 6275 aaa ttc caa gaa ccc tgg aaa ttc ctc aaa tgc tac cgc caa aaa 31204 Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 6280 6285 6290 tca gac atg cat ccc agc tgg atc atg atc att ggg atc gtg aac 31249 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn 6295 6300 6305 att ctg gcc tgc acc ctc atc tcc ttt gtg att tac ccc tgc ttt 31294 Ile Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe 6310 6315 6320 gac ttt ggt tgg aac tcg cca gag gcg ctc tat ctc ccg cct gaa 31339 Asp Phe Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu 6325 6330 6335 cct gac aca cca cca cag caa cct cag gca cac gca cta cca cca 31384 Pro Asp Thr Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro 6340 6345 6350 cca cca cag cct agg cca caa tac atg ccc ata tta gac tat gag 31429 Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu 6355 6360 6365 gcc gag cca cag cga ccc atg ctc ccc gct att agt tac ttc aat 31474 Ala Glu Pro Gln Arg Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn 6370 6375 6380 cta acc ggc gga gat gac tgacccactg gccaacaaca acgtcaacga 31522 Leu Thr Gly Gly Asp Asp 6385 6390 ccttctcctg gacatggacg gccgcgcctc ggagcagcga ctcgcccaac ttcgcattcg 31582 ccagcagcag gagagagccg tcaaggagct gcaggacggc atagccatcc accagtgcaa 31642 gaaaggcatc ttctgcctgg tgaaacaggc caagatctcc tacgaggtca cccagaccga 31702 ccatcgcctc tcctacgagc tcatgcagca gcgccagaag ttcacctgcc tggtcggagt 31762 caaccccatc gtcatcaccc agcagtcggg cgataccaag gggtgcatcc actgctcctg 31822 cgactccccc gactgcgtcc acactctgat caagaccctc tgcggcctcc gcgacctcct 31882 ccccatgaac taatcacccc cttatccagt gaaataaaga tcatattgat gattaaataa 31942 aaaaaataat catttgattt gaaataaaga tacaatcata ttgatgattt gagtttaata 32002 aaaataaaga atcacttact tgaaatctga taccaggtct ctgtccatgt tttctgccaa 32062 caccacttca ctcccctctt cccagctctg gtactgcagg ccccggcggg ctgcaaactt 32122 cctccacacc ctgaagggga tgtcaaattc ctcctgtccc tcaatcttca ttttatcttc 32182 tatcag atg tcc aaa aag cgc gtc cgg gtg gat gat gac ttc gac ccc 32230 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro 6395 6400 gtc tac ccc tac gat gca gac aac gca ccg acc gtg ccc ttc atc 32275 Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile 6405 6410 6415 aac ccc ccc ttc gtc tct tca gat gga ttc caa gag aag ccc ctg 32320 Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu 6420 6425 6430 ggg gtg ctg tcc ctg cgt ctg gcc gat ccc gtc acc acc aag aac 32365 Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn 6435 6440 6445 ggg gaa atc acc ctc aag ctg gga gat ggg gtg gac ctc gac gac 32410 Gly Glu Ile Thr Leu Lys Leu Gly Asp Gly Val Asp Leu Asp Asp 6450 6455 6460 tcg gga aaa ctc atc tcc aac acg gcc acc aag gcc gcc gcc cct 32455 Ser Gly Lys Leu Ile Ser Asn Thr Ala Thr Lys Ala Ala Ala Pro 6465 6470 6475 ctc agt ttt tcc aac aac acc att tcc ctt aac atg gat acc cct 32500 Leu Ser Phe Ser Asn Asn Thr Ile Ser Leu Asn Met Asp Thr Pro 6480 6485 6490 ctt tac aac aac aat gga aag cta ggt atg aag gta acc gca cca 32545 Leu Tyr Asn Asn Asn Gly Lys Leu Gly Met Lys Val Thr Ala Pro 6495 6500 6505 tta aag ata tta gac aca gat cta cta aaa aca ctt gtt gtt gct 32590 Leu Lys Ile Leu Asp Thr Asp Leu Leu Lys Thr Leu Val Val Ala 6510 6515 6520 tat ggg cag gga tta gga aca aac acc aat ggt gct ctt gtt gcc 32635 Tyr Gly Gln Gly Leu Gly Thr Asn Thr Asn Gly Ala Leu Val Ala 6525 6530 6535 caa cta gca tac cca ctt gtt ttt aat acc gct agc aaa att gcc 32680 Gln Leu Ala Tyr Pro Leu Val Phe Asn Thr Ala Ser Lys Ile Ala 6540 6545 6550 ctt aat tta ggc aat gga cca tta aaa gtg gat gca aat aga ctg 32725 Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala Asn Arg Leu 6555 6560 6565 aac att aat tgc aaa aga ggt atc tat gtc act acc aca aaa gat 32770 Asn Ile Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr Lys Asp 6570 6575 6580 gca ctg gag att aat atc agt tgg gca aat gct atg aca ttt ata 32815 Ala Leu Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe Ile 6585 6590 6595 gga aat gcc att ggt gtc aat att gac aca aaa aaa ggc cta cag 32860 Gly Asn Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln 6600 6605 6610 ttc ggc act tca agc act gaa aca gat gtt aaa aat gct ttt cca 32905 Phe Gly Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro 6615 6620 6625 ctc caa gta aaa ctt gga gct ggt ctt aca ttt gac agc aca ggt 32950 Leu Gln Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly 6630 6635 6640 gcc att gtt gct tgg aac aaa gaa gat gac aaa ctt aca ctg tgg 32995 Ala Ile Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp 6645 6650 6655 acc aca gcc gat cca tct cca aac tgt cac ata tat tct gca aag 33040 Thr Thr Ala Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys 6660 6665 6670 gat gct aag ctt aca ctc tgc ttg aca aag tgt ggt agt cag ata 33085 Asp Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile 6675 6680 6685 ctg ggc act gtt tct ctc ata gct gtt gat act ggt agc tta aat 33130 Leu Gly Thr Val Ser Leu Ile Ala Val Asp Thr Gly Ser Leu Asn 6690 6695 6700 cca ata aca gga aaa gta acc act gct ctt gtt tca ctt aaa ttc 33175 Pro Ile Thr Gly Lys Val Thr Thr Ala Leu Val Ser Leu Lys Phe 6705 6710 6715 gat gcc aat gga gtt ttg caa gcc agt tca aca cta gat aaa gaa 33220 Asp Ala Asn Gly Val Leu Gln Ala Ser Ser Thr Leu Asp Lys Glu 6720 6725 6730 tat tgg aat ttc aga aaa gga gat gtg aca cct gct gac ccc tac 33265 Tyr Trp Asn Phe Arg Lys Gly Asp Val Thr Pro Ala Asp Pro Tyr 6735 6740 6745 act aat gct ata ggc ttt atg ccc aac ctt aat gca tac cca aaa 33310 Thr Asn Ala Ile Gly Phe Met Pro Asn Leu Asn Ala Tyr Pro Lys 6750 6755 6760 aac aca aac gca gct gca aaa agt cac att gtt gga aaa gta tac 33355 Asn Thr Asn Ala Ala Ala Lys Ser His Ile Val Gly Lys Val Tyr 6765 6770 6775 cta cat ggg gat gta agc aag cca cta gac ttg ata att aca ttt 33400 Leu His Gly Asp Val Ser Lys Pro Leu Asp Leu Ile Ile Thr Phe 6780 6785 6790 aat gaa acc agt gat gaa tcc tgt act tat tgc att aac ttt cag 33445 Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile Asn Phe Gln 6795 6800 6805 tgg cag tgg gga act gac caa tat aaa gat gaa aca ctt gca gtc 33490 Trp Gln Trp Gly Thr Asp Gln Tyr Lys Asp Glu Thr Leu Ala Val 6810 6815 6820 agt tca ttc acc ttc tca tac att gct aaa gaa taacatccac 33533 Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 6825 6830 6835 cctgcatgcc aacccatttc cctctatcta tacatggaaa actctgaagc agaaaaaata 33593 aagttcaagt gttttattga ttcaacagtt tttacagaat tcgagtagtt attttccctc 33653 caccctccca actcatggaa tacaccatcc tctccccacg cacagcctta aacatctgaa 33713 tgccattggt aatggacatg gttttggcct ccacattcca cacagtttca gagcgagcca 33773 gtctcgggtc ggtcagggag atgaaaccct ccgggcactc ctgcatctgc acctcacagt 33833 tcaacagctg agggctgtcc tcggtggtcg ggatcacggt tatctggaag aagagcgatg 33893 agaatcataa tccgcgaacg ggatcgggcg gttgtggcgc atcaggcccc gcagcagtcg 33953 ctgtctgcgc cgctccgtca agctgctgct caaggggtcc gggtccaggg actccctgcg 34013 catgatgccg atggccctga gcatcagtcg cctggtgcgg cgggcgcagc agcggatgcg 34073 gatctcactc aggtcggagc agtacgtgca gcacagcacc accaagttgt tcaacagtcc 34133 atagttcaac acgctccagc caaaactcat ctgtggaact atgctgccca cgtgtccatc 34193 gtaccagatc ctgatgtaaa tcaggtggcg ccccctccag aacacactgc ccatgtacat 34253 gatctccttg ggcatatgca ggttcaccac ctcccggtac cacatcaccc gctggttgaa 34313 catgcagccc tggataattc tgcggaacca gatggccagc accgccccgc ccgccatgca 34373 gcgcagggac cccgggtcct gacagtggca gtggaggacc caccgctcgc ggccgtggat 34433 caactgggag ctgaacaggt ctatgttggc acagcacagg cacacgctca tgcatgtctt 34493 cagcactctc agttcctcgg gggtcaggac catgtcccag ggcacgggga actcttgcag 34553 gacagtgaac ccggcagaac agggcagccc tcgcacacaa cttacattgt gcatggacag 34613 ggtatcgcaa tcaggcagca ccggatgatc ctccaccaga gaagcgcggg tctcggtctc 34673 ctcacaacga ggtaaggggg ccggcggttg gtacggatga tggcgggatg acgctaatcg 34733 tgttctggat cgtgtcatga tggagcttct tcctgacatc ttcgtatttc atgtagcaga 34793 acctggtccg ggcactgcac accgctcgcc ggcgacggtc tcggcgcttc gagcgctcgg 34853 tgttgaagtt gtaaaacagc cactccctca gagcgtgcag tatctcttga gcctcttggg 34913 tgatgaaaat cccatccgcc ctgatggctc tgatcacatc gaccacggtg gaatgggcca 34973 gacccagcca gatgatgcaa ttttgttggg tttcggtgac ggcgggggag ggaagaacag 35033 gaagaaccat gattaacttt attccaaacg gtctcggagc acttcaaaat gcaggtcgcg 35093 gagatggcac ctctcgcccc cactgtgttg atggaaaata acagccaggt caaaggtgac 35153 acggttctcg agatgttcca cggtggcttc cagcaaagcc tccacgcgca catccagaaa 35213 caagaggaca gcgaaagcgg gagcgttctc taattcctca atcatcatat tacactcctg 35273 caccatcccc agataatttt catttttcca gccttgaatg atttgaacta gttcctgagg 35333 taaatccaag ccagccatga taaaaagctc gcgcagagcg ccctccaccg gcattcttaa 35393 gcacaccctc ataattccaa gagattctgc tcctggttca cctgcagcag attaacaagg 35453 ggaatatcaa aatctctgcc gcgatctcta agctcctccc tcagcaataa ctgcaagtac 35513 tctttcatat cttctccgaa atttttagcc atagggccgc caggaatgag agcagggcaa 35573 gccacattac agataaagcg aagtcctccc cagtgagcat tgccaaatgt aagattgaaa 35633 taagcatgct ggctagaccc ggtgatatct tccagataac tggacagaaa atcaggcaag 35693 caatttttaa gaaaatcaac aaaagaaaag tcgtccaggt gcaagtttag agcctcagga 35753 acaacgatgg aataagtgca aggagtgcgt tccagcatgg ttagtgtttt tttggtgatc 35813 tgtagaacaa aaaataaaca tgcaatatta aaccatgcta gcctggcgaa caggtgggta 35873 aatcactctt tccagcacca ggcaggctac ggggtctccg gcgcgaccct cgtagaagct 35933 gtcgccatga ttgaaaagca tcaccgaaag actttcccgg tggccggcat ggatgattcg 35993 cgaagacgcg tacactccgg gaacattggc atccgtgagt gaaaaaaatc gccccaagaa 36053 gccccgaggc actacaatgc tcaaccttaa ttccagcaga gcgaccccat gcggatgaag 36113 cacaaaattg gtaggtgcgt aaaaaatgta attactcccc tcctgcacag gcagcaaagc 36173 ccccgctccc tccagaaaca catacaaagc ctcagcgtcc atagcttacc gagcacggca 36233 ggcgcaagat tcagagaaaa ggctgagctc taacctgact gcccgctcct gagctcaata 36293 tatagcccta acctacactg acgtaaaggc caaagtctaa aaatacccgc caaaatgaca 36353 cacacgccca gcacacgccc agaaaccggt gacacactca aaaaaatacg tgcgcttcct 36413 caaacgccca aaccggcgtc atttccgggt tcccacgcta cgtcaccgct cagcgacttt 36473 caaatttcgt cgaccgttaa acacgtcact cgccccgccc ctaacggtcg ccctcctctc 36533 ggccaatcac agccccgcat ccccaaattc aaacgcctca tttgcatatt aacgcgcacc 36593 aaaagtttga ggtatattat tgatgatg 36621 <210> 99 <211> 503 <212> PRT <213> Simian adenovirus 30 <400> 99 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser 65 70 75 80 Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu 85 90 95 Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile 100 105 110 Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val 115 120 125 Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val 130 135 140 Gln Ser Gln Gly Val Asp Glu Val Ser Val Met His Glu Lys Tyr Ser 145 150 155 160 Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu 165 170 175 Val Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys 180 185 190 Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser 195 200 205 Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe 210 215 220 Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly 225 230 235 240 Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val 245 250 255 Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe 260 265 270 Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg 275 280 285 Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys 290 295 300 Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly 305 310 315 320 Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu 325 330 335 Thr Gly Cys Phe Val Cys Ile Lys Gly Asn Ala Gln Val Lys His Asn 340 345 350 Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys 355 360 365 Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His 370 375 380 Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys 385 390 395 400 Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys 405 410 415 Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg 420 425 430 Val Ser Leu Ala Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile 435 440 445 Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly 450 455 460 Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp 465 470 475 480 Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly 485 490 495 Ser Ser Gly Glu Glu Ser Asp 500 <210> 100 <211> 157 <212> PRT <213> Simian adenovirus 30 <400> 100 Met Arg Gly Arg Met Thr Lys Ile Cys Val Phe Leu Cys Ser Ser Met 1 5 10 15 Ser Gly Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr 20 25 30 Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser 35 40 45 Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr 50 55 60 Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala 65 70 75 80 Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly 85 90 95 Tyr Tyr Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala 100 105 110 Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala 115 120 125 Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln 130 135 140 Ala Glu Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 145 150 155 <210> 101 <211> 392 <212> PRT <213> Simian adenovirus 30 <400> 101 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln 20 25 30 Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Ser 35 40 45 Tyr Asp His Gln Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu 50 55 60 Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg Asp 65 70 75 80 Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser 85 90 95 Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg 100 105 110 Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp 115 120 125 Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val 130 135 140 Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu 145 150 155 160 Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala 165 170 175 Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu 180 185 190 Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe 195 200 205 Leu Val Val Gln His Ser Arg Asp Asn Glu Thr Phe Arg Glu Ala Leu 210 215 220 Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn 225 230 235 240 Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu 245 250 255 Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr 260 265 270 Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val 275 280 285 Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu 290 295 300 Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val 305 310 315 320 Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser 325 330 335 Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe 340 345 350 Asp Met Gly Ala Asp Leu Arg Trp Gln Pro Ser Arg Arg Ala Leu Glu 355 360 365 Ala Ala Gly Gly Ser Pro Tyr Val Glu Glu Val Asp Asp Glu Val Asp 370 375 380 Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 <210> 102 <211> 593 <212> PRT <213> Simian adenovirus 30 <400> 102 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Thr Ser Arg Gly Ser Ala 530 535 540 Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp 545 550 555 560 Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser 565 570 575 Gly Gly Gly Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met 580 585 590 Met <210> 103 <211> 533 <212> PRT <213> Simian adenovirus 30 <400> 103 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Gly Glu Asp Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Glu Ala Ala Ala 290 295 300 Glu Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp 305 310 315 320 Asn Phe Ala Ser Ala Ala Ala Val Ala Ala Ala Glu Ala Ala Glu Thr 325 330 335 Glu Ser Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asn Arg 340 345 350 Ser Tyr Asn Val Leu Pro Asp Lys Ile Asn Thr Ala Tyr Arg Ser Trp 355 360 365 Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp 370 375 380 Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr 385 390 395 400 Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr 405 410 415 Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val 420 425 430 Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu 435 440 445 Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn 450 455 460 Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu 465 470 475 480 Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser 485 490 495 Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr 500 505 510 Cys Pro Tyr Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu 515 520 525 Ser Ser Arg Thr Phe 530 <210> 104 <211> 193 <212> PRT <213> Simian adenovirus 30 <400> 104 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 105 <211> 346 <212> PRT <213> Simian adenovirus 30 <400> 105 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Ala Ala Val Lys Glu Glu Arg Lys Pro Arg 20 25 30 Lys Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Val Asp Asp 35 40 45 Val Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp 50 55 60 Arg Gly Arg Lys Val Gln Pro Val Leu Arg Pro Gly Thr Thr Val Val 65 70 75 80 Phe Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 85 90 95 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu 100 105 110 Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu 115 120 125 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys 130 135 140 Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly 145 150 155 160 Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val 165 170 175 Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val Asp 180 185 190 Pro Asp Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala 195 200 205 Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro 210 215 220 Met Glu Thr Gln Thr Glu Pro Met Ile Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Pro Thr Ser Ser Arg 245 250 255 Arg Pro Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr 260 265 270 Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 275 280 285 Phe Tyr Arg Gly His Thr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr 290 295 300 Arg Arg Arg Arg Arg Arg Thr Ala Ala Ala Ala Thr Thr Pro Ala Ala 305 310 315 320 Leu Val Arg Arg Val Tyr Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro 325 330 335 Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 106 <211> 77 <212> PRT <213> Simian adenovirus 30 <400> 106 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 107 <211> 259 <212> PRT <213> Simian adenovirus 30 <400> 107 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro 195 200 205 Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala 210 215 220 Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser 225 230 235 240 Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg 245 250 255 Arg Cys Tyr <210> 108 <211> 938 <212> PRT <213> Simian adenovirus 30 <400> 108 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Ser Ser Gln Trp Glu Gln Asn Glu Asn Asn Gly Gln Gly 130 135 140 Gln Ala Lys Thr His Thr Tyr Gly Val Ala Ala Met Gly Gly Leu Asp 145 150 155 160 Ile Thr Lys Glu Gly Leu Gln Ile Gly Thr Asp Ala Ser Lys Glu Asp 165 170 175 Asp Asn Glu Ile Tyr Ala Asp Glu Thr Tyr Gln Pro Glu Pro Gln Ile 180 185 190 Gly Glu Glu Asn Trp Gln Asp Thr Glu Asn Phe Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Lys Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Arg 210 215 220 Pro Thr Asn Val Lys Gly Gly Gln Ala Lys Val Lys Thr Glu Glu Asn 225 230 235 240 Val Gln Ser Phe Asp Ile Asp Leu Ala Phe Phe Asp Ile Pro Ser Thr 245 250 255 Gly Thr Gly Ser Asn Gly Thr Asn Val Asn Asp Lys Pro Asp Met Val 260 265 270 Met Tyr Thr Glu Asn Val Asn Leu Glu Thr Pro Asp Thr His Ile Val 275 280 285 Tyr Lys Pro Gly Thr Ser Asp Asp Ser Ser Glu Ala Asn Leu Cys Gln 290 295 300 Gln Ala Met Pro Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe 305 310 315 320 Ile Gly Leu Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala 325 330 335 Gly Gln Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn 340 345 350 Thr Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr 355 360 365 Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp 370 375 380 Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr 385 390 395 400 Cys Phe Pro Leu Asp Gly Ala Gly Thr Asn Ala Val Tyr Gln Gly Val 405 410 415 Lys Glu Lys Thr Gly Asn Asn Gly Glu Trp Glu Ala Asp Thr Asn Val 420 425 430 Ala Ser Gln Asn Gln Ile Cys Lys Gly Asn Ile Tyr Ala Met Glu Ile 435 440 445 Asn Leu Gln Ala Asn Leu Trp Arg Ser Phe Leu Tyr Ser Asn Val Ala 450 455 460 Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Ile Thr Leu 465 470 475 480 Pro Thr Asn Thr Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Pro 485 490 495 Pro Ser Leu Val Asp Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu 500 505 510 Asp Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly 515 520 525 Leu Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe 530 535 540 His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu 545 550 555 560 Leu Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn 565 570 575 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala 580 585 590 Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met 595 600 605 Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr 610 615 620 Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr 625 630 635 640 Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg 645 650 655 Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys 660 665 670 Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser 675 680 685 Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe 690 695 700 Lys Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn 705 710 715 720 Asp Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp 725 730 735 Gly Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe 740 745 750 Leu Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr 755 760 765 Val Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe 770 775 780 Gln Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr 785 790 795 800 Gln Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly 805 810 815 Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr 820 825 830 Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys 835 840 845 Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn 850 855 860 Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr 865 870 875 880 Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met 885 890 895 Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val 900 905 910 Arg Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg 915 920 925 Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 <210> 109 <211> 209 <212> PRT <213> Simian adenovirus 30 <400> 109 Met Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile 1 5 10 15 Ile Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys 20 25 30 Arg Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val 35 40 45 Asn Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala 50 55 60 Trp Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe 65 70 75 80 Ser Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu 85 90 95 Leu Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu 100 105 110 Lys Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu 115 120 125 Phe Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 130 135 140 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 145 150 155 160 Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu 165 170 175 Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His 180 185 190 Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp 195 200 205 Met <210> 110 <211> 801 <212> PRT <213> Simian adenovirus 30 <400> 110 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ser 1 5 10 15 Thr Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro 20 25 30 Pro Pro Ser Pro Thr Ser Asp Ala Ala Ala Pro Asp Met Gln Glu Met 35 40 45 Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His 50 55 60 Glu Glu Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln 65 70 75 80 Glu Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Asn Gln Ala Gly Leu 85 90 95 Glu His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 100 105 110 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala 115 120 125 Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn 130 135 140 Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys 145 150 155 160 Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu 165 170 175 Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val 180 185 190 Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly 195 200 205 Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys 210 215 220 Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 225 230 235 240 Gln Gly Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu 290 295 300 Glu Glu Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val 305 310 315 320 Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln 325 330 335 Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 340 345 350 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu 355 360 365 Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val 370 375 380 Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser 385 390 395 400 Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His 405 410 415 Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val 420 425 430 Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln 435 440 445 Gln Cys Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln 450 455 460 Lys Asn Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala 465 470 475 480 Ser Asp Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu 485 490 495 Arg Asn Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe 500 505 510 Arg Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 515 520 525 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro 530 535 540 Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala 545 550 555 560 Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu 565 570 575 Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 580 585 590 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu 595 600 605 Gln Gly Pro Gly Asp Ser Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro 610 615 620 Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr 625 630 635 640 His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys 645 650 655 Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln 660 665 670 Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly 675 680 685 His Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser 690 695 700 Phe Pro Gln Asp Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly 725 730 735 Gly Asp Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala 740 745 750 Arg Gln Ser Gly Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg 755 760 765 Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser Lys Gln 770 775 780 His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro 785 790 795 800 Gln <210> 111 <211> 227 <212> PRT <213> Simian adenovirus 30 <400> 111 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala Arg Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 112 <211> 208 <212> PRT <213> Simian adenovirus 30 <400> 112 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Pro Leu Pro Ala Thr Asn Asn 115 120 125 Gln Thr Asn Leu His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser 130 135 140 Asn Thr Thr Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile 145 150 155 160 Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val 165 170 175 Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser 180 185 190 Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 195 200 205 <210> 113 <211> 228 <212> PRT <213> Simian adenovirus 30 <400> 113 Met Arg Leu Leu Asn Phe Leu Asn Ile Val Leu Ser Ile Ala Tyr Ala 1 5 10 15 Ser Gly Tyr Ala Asn Ile Gln Lys Thr Leu Tyr Val Gly Ser Asp Gly 20 25 30 Thr Leu Glu Gly Thr Gln Ser Gln Ala Lys Val Ala Trp Tyr Phe Tyr 35 40 45 Arg Thr Asn Thr Asp Pro Val Lys Leu Cys Lys Gly Glu Leu Pro Arg 50 55 60 Thr His Lys Thr Pro Leu Thr Phe Ser Cys Ser Asn Asn Asn Leu Thr 65 70 75 80 Leu Phe Ser Ile Thr Lys Gln Tyr Thr Gly Thr Tyr Tyr Ser Thr Asn 85 90 95 Phe His Thr Gly Gln Asp Lys Tyr Tyr Thr Val Lys Val Glu Asn Pro 100 105 110 Thr Thr Pro Arg Thr Thr Thr Thr Thr Thr Thr Thr Ala Lys Pro Thr 115 120 125 Val Lys Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser 130 135 140 Thr Thr Leu Ala Ala Thr Thr His Thr His Thr Lys Leu Thr Leu Gln 145 150 155 160 Thr Thr Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr 165 170 175 Thr Ser Asn Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala 180 185 190 Val Val Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala 195 200 205 Phe Cys Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu 210 215 220 Ser Val Glu Phe 225 <210> 114 <211> 203 <212> PRT <213> Simian adenovirus 30 <400> 114 Met Lys Ile Leu Gly Leu Phe Ser Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Arg Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Thr Asp Gln Thr Glu Leu Cys Asn Phe Gln Lys Gly Lys 50 55 60 Thr Ser Asn Ser Lys Ile Ser Asn Tyr Gln Cys Asn Gly Thr Asp Leu 65 70 75 80 Ile Leu Leu Asn Val Thr Lys Ala Tyr Gly Gly Ser Tyr Tyr Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Val Glu Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Thr Thr Thr Thr Ile His Thr Thr His Thr Glu 115 120 125 Gln Thr Pro Glu Ala Thr Glu Ala Glu Leu Ala Phe Gln Val His Gly 130 135 140 Asp Ser Phe Ala Val Asn Thr Pro Thr Pro Asp Gln Arg Cys Pro Gly 145 150 155 160 Pro Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile 165 170 175 Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg 180 185 190 Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 115 <211> 288 <212> PRT <213> Simian adenovirus 30 <400> 115 Met Lys Ala Val Ser Ala Leu Val Phe Cys Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Asn Ser Lys Ile Thr Lys Val Ser Phe Ile Lys His Val Asn Val 20 25 30 Thr Glu Gly Asp Asn Ile Thr Leu Ala Gly Val Glu Gly Ala Gln Asn 35 40 45 Thr Thr Trp Thr Lys Tyr His Leu Gly Trp Arg Asp Ile Cys Thr Trp 50 55 60 Asn Val Thr Tyr Tyr Cys Ile Gly Ile Asn Leu Thr Ile Val Asn Ala 65 70 75 80 Asn Gln Ser Gln Asn Gly Leu Ile Lys Gly Gln Ser Val Ser Val Thr 85 90 95 Ser Asp Gly Tyr Tyr Thr Gln His Ser Phe Asn Tyr Asn Ile Thr Val 100 105 110 Ile Pro Leu Pro Thr Pro Ser Pro Pro Ser Thr Thr Thr Gln Thr Thr 115 120 125 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val 130 135 140 Ala Ser Ser Ser Gly Val Arg Val Ala Phe Leu Met Leu Ala Pro Ser 145 150 155 160 Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser 165 170 175 Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr 180 185 190 Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile Ser Pro Ala Thr Thr 195 200 205 Pro Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Asp Gly Gly 210 215 220 Met Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu 225 230 235 240 Ala Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His 245 250 255 Arg Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Gln Pro Glu Pro Leu 260 265 270 Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 116 <211> 91 <212> PRT <213> Simian adenovirus 30 <400> 116 Met Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 50 55 60 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Arg Val Ala Gln Leu Leu Arg Leu Leu 85 90 <210> 117 <211> 144 <212> PRT <213> Simian adenovirus 30 <400> 117 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Pro Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Pro Gln Pro 100 105 110 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 115 120 125 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 118 <211> 445 <212> PRT <213> Simian adenovirus 30 <400> 118 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Glu Ile Thr Leu 50 55 60 Lys Leu Gly Asp Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Asn Thr Ala Thr Lys Ala Ala Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Asn Asn Asn Gly Lys Leu 100 105 110 Gly Met Lys Val Thr Ala Pro Leu Lys Ile Leu Asp Thr Asp Leu Leu 115 120 125 Lys Thr Leu Val Val Ala Tyr Gly Gln Gly Leu Gly Thr Asn Thr Asn 130 135 140 Gly Ala Leu Val Ala Gln Leu Ala Tyr Pro Leu Val Phe Asn Thr Ala 145 150 155 160 Ser Lys Ile Ala Leu Asn Leu Gly Asn Gly Pro Leu Lys Val Asp Ala 165 170 175 Asn Arg Leu Asn Ile Asn Cys Lys Arg Gly Ile Tyr Val Thr Thr Thr 180 185 190 Lys Asp Ala Leu Glu Ile Asn Ile Ser Trp Ala Asn Ala Met Thr Phe 195 200 205 Ile Gly Asn Ala Ile Gly Val Asn Ile Asp Thr Lys Lys Gly Leu Gln 210 215 220 Phe Gly Thr Ser Ser Thr Glu Thr Asp Val Lys Asn Ala Phe Pro Leu 225 230 235 240 Gln Val Lys Leu Gly Ala Gly Leu Thr Phe Asp Ser Thr Gly Ala Ile 245 250 255 Val Ala Trp Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Ala 260 265 270 Asp Pro Ser Pro Asn Cys His Ile Tyr Ser Ala Lys Asp Ala Lys Leu 275 280 285 Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly Thr Val Ser 290 295 300 Leu Ile Ala Val Asp Thr Gly Ser Leu Asn Pro Ile Thr Gly Lys Val 305 310 315 320 Thr Thr Ala Leu Val Ser Leu Lys Phe Asp Ala Asn Gly Val Leu Gln 325 330 335 Ala Ser Ser Thr Leu Asp Lys Glu Tyr Trp Asn Phe Arg Lys Gly Asp 340 345 350 Val Thr Pro Ala Asp Pro Tyr Thr Asn Ala Ile Gly Phe Met Pro Asn 355 360 365 Leu Asn Ala Tyr Pro Lys Asn Thr Asn Ala Ala Ala Lys Ser His Ile 370 375 380 Val Gly Lys Val Tyr Leu His Gly Asp Val Ser Lys Pro Leu Asp Leu 385 390 395 400 Ile Ile Thr Phe Asn Glu Thr Ser Asp Glu Ser Cys Thr Tyr Cys Ile 405 410 415 Asn Phe Gln Trp Gln Trp Gly Thr Asp Gln Tyr Lys Asp Glu Thr Leu 420 425 430 Ala Val Ser Ser Phe Thr Phe Ser Tyr Ile Ala Lys Glu 435 440 445 <210> 119 <211> 580 <212> DNA <213> Simian adenovirus 30 <220> <221> CDS <222> (1)..(573) <223> label=Elb\19K <400> 119 atg gag atc tgg aca gtc ttg gaa gac ttt cac cag act aga cag ctg 48 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 cta gag aac tca tcg gag gga gtc tct tac ctg tgg aga ttc tgc ttc 96 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 gct ggg cct cta gct aag cta gtc tat agg gcc aag cag gat tat agg 144 Ala Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg 35 40 45 gaa caa ttt gag gat att ttg aga gag tgt cct ggt att ttt gac tct 192 Glu Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 ctc aac ttg ggc cat cag tct cac ttt aac cag agt att ctg aga gcc 240 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 ctt gac ttt tct act cct ggc aga act acc gcc gcg gta gcc ttt ttt 288 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 gcc ttt atc ctt gac aaa tgg agt caa gaa acc cat ttc agc agg gat 336 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 tac cgt ctg gac tgc tta gca gta gct ttg tgg aga aca tgg agg tgc 384 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 cag cgc ctg aat gca atc tcc ggc tac ttg cca gta cag ccg gta gac 432 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 acg ctg agg atc ctg agt ctc cag tca ccc cag gaa cac caa cgc cgc 480 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 cag cag ccg cag cag gag cag cag caa gag gag gag gac cga gaa gag 528 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu 165 170 175 aac ccg aga gcc ggt ctg gac cct ccg gtg gcg gag gag gag gag 573 Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 tagctga 580 <210> 120 <211> 191 <212> PRT <213> Simian adenovirus 30 <400> 120 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Ala Gly Pro Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Arg 35 40 45 Glu Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Asp Arg Glu Glu 165 170 175 Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 121 <211> 6360 <212> DNA <213> Simian adenovirus 30 <220> <221> CDS <222> (8)..(571) <223> label=22K <220> <221> CDS <222> (1595)..(1912) <223> label=E3\12.5K <220> <221> CDS <222> (2477)..(3004) <223> label=E3\gp19K <220> <221> CDS <222> (5948)..(6352) <223> label=E3\14.7K <400> 121 ccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 49 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag 97 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 15 20 25 30 atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac 145 Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca 193 Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg gag gag aaa gca agc agc acg 241 Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 289 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 aga tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc ggt 337 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly 95 100 105 110 aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc 385 Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala 115 120 125 atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg 433 Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg 130 135 140 cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg 481 Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu 145 150 155 cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa gag 529 His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu 160 165 170 gca gaa acc cag cag cag cag aaa acc agc ggc agc agc agc 571 Ala Glu Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser 175 180 185 tagaaaatcc acagcggcgg caggtggact gaggatcgcg gcgaacgagc cggcgcagac 631 ccgggagctg aggaaccgga tctttcccac cctctatgcc atcttccagc agagtcgggg 691 gcaggagcag gaactgaaag tcaagaaccg ttctctgcgc tcgctcaccc gcagttgtct 751 gtatcacaag agcgaagacc aacttcagcg cactctcgag gacgccgagg ctctcttcaa 811 caagtactgc gcgctcactc ttaaagagta gcccgcgccc gcccacacac ggaaaaaggc 871 gggaattacg tcaccacctg cgcccttcgc ccgaccatca tgagcaaaga gattcccacg 931 ccttacatgt ggagctacca gccccagatg ggcctggccg ccggcgccgc ccaggactac 991 tccacccgca tgaactggct cagtgccggg cccgcgatga tctcacgggt gaatgacatc 1051 cgcgcccgcc gaaaccagat actcctagaa cagtcagcga tcaccgccac gccccgccat 1111 caccttaatc cgcgtaattg gcccgccgcc ctggtgtacc aggaaattcc ccagcccacg 1171 accgtactac ttccgcgaga cgcccaggcc gaagtccagc tgactaactc aggtgtccag 1231 ctggccggcg gcgccgccct gtgtcgtcac cgccccgctc agggtataaa gcggctggtg 1291 atccgaggca gaggcacaca gctcaacgac gaggtggtga gctcttcgct gggtctgcga 1351 cctgacggag tcttccaact cgccggatcg gggagatctt ccttcacgcc tcgtcaggcc 1411 gtcctgactt tggagagttc gtcctcgcag ccccgctcgg gcggcatcgg cactctccag 1471 ttcgtggagg agttcactcc ctcggtctac ttcaacccct tctccggctc ccccggccac 1531 tacccggacg agttcatccc gaacttcgac gccatcagcg agtcggtgga cggctacgat 1591 tga atg tcc cat ggt ggc gca gct gac cta gct cgg ctt cga cac ctg 1639 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu 190 195 200 gac cac tgc cgc cgc ttc cgc tgc ttc gct cgg gat ctc gcc gag ttt 1687 Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe 205 210 215 gcc tac ttt gag ctg ccc gag gag cac cct cag ggc cca gcc cac gga 1735 Ala Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly 220 225 230 235 gtg cgg atc atc gtc gaa ggg ggc ctc gac tcc cac ctg ctt cgg atc 1783 Val Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile 240 245 250 ttc agc cag cga ccg atc ctg gtc gag cgc gaa caa gga cag acc cgt 1831 Phe Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg 255 260 265 ctg acc ctg tac tgc atc tgc aac cac ccc ggc ctg cat gaa agt ctt 1879 Leu Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu 270 275 280 tgt tgt ctg ctg tgt act gag tat aat aaa agc tgagatcagc gactactccg 1932 Cys Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 285 290 gactcgattg tggtgttcct gctatcaacc ggtccctgtt cttcaccggg aacgaaaccg 1992 agctccagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctccc 2052 ccatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 2112 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 2172 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgc 2232 cgctccccgc tactaacaac caaactaacc tccaccaacg ccaccgtcgc gacctttcct 2292 ctgaatctaa taccactacc ggaggtgagc tccgaggtcg accaacctct gggatttact 2352 acggcccctg ggaggtggtg gggttaatag cgctaggcct agttgtgggt gggcttttgg 2412 ctctctgcta cctatacctc ccttgctgtt cgtacttagt ggtgctgtgt tgctggttta 2472 agaa atg ggg cag atc acc cta gtg agc tgc ggt gtg ctg gtg gcg gtg 2521 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val 295 300 305 ctt tcg att gtg gga ctg ggc ggc gcg gct gta gtg aag gag gag aag 2569 Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys 310 315 320 325 gcc gat ccc tgc ttg cat ttc aat ccc gac aaa tgc cag ctg agt ttt 2617 Ala Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe 330 335 340 cag ccc gat ggc aat cgg tgc gcg gtg ctg atc aag tgc gga tgg gaa 2665 Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu 345 350 355 tgc gag aac gtg aga atc gag tac aat aac aag act cgg aac aat act 2713 Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr 360 365 370 ctc gcg tcc gtg tgg cag ccc ggg gac ccc gag tgg tac acc gtc tct 2761 Leu Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser 375 380 385 gtc ccc ggt gct gac ggc tcc ccg cgc acc gtg aat aat act ttc att 2809 Val Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile 390 395 400 405 ttt gcg cac atg tgc aac acg gtc atg tgg atg agc aag cag tac gat 2857 Phe Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp 410 415 420 atg tgg ccc ccc acg aag gag aac atc gtg gtc ttc tcc atc gct tac 2905 Met Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr 425 430 435 agc ctg tgc acg gcg cta atc acc gct atc gtg tgc ctg agc att cac 2953 Ser Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His 440 445 450 atg ctc atc gct att cgc ccc aga aat aat gcc gag aaa gag aaa cag 3001 Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln 455 460 465 cca taacacgttt tttcacacac cttgttttta cagacaatgc gtctgttaaa 3054 Pro 470 ttttttaaac attgtgctca gtattgctta tgcctctggt tatgcaaaca tacagaaaac 3114 cctttatgta ggatctgatg gtacactaga gggtacccaa tcacaagcca aggttgcatg 3174 gtatttttat agaaccaaca ctgatccagt taaactttgt aagggtgaat tgccgcgtac 3234 acataaaact ccacttacat ttagttgcag caataataat cttacacttt tttcaattac 3294 aaaacaatat actggtactt attacagtac aaactttcat acaggacaag ataaatatta 3354 tactgttaag gtagaaaatc ctaccactcc tagaactacc accaccacca ccactactgc 3414 aaagcccact gtgaaaacta caactaggac caccacaact acagaaacca ccaccagcac 3474 aacacttgct gcaactacac acacacacac taagctaacc ttacagacca ctaatgattt 3534 gatcgccctg ctgcaaaagg gggataacag caccacttcc aatgaggaga tacccaaatc 3594 catgattggc attattgttg ctgtagtggt gtgcatgttg atcatcgcct tgtgcatggt 3654 gtactatgcc ttctgctaca gaaagcacag actgaacgac aagctggaac acttactaag 3714 tgttgaattt taatttttta gaaccatgaa gatcctaggc ctttttagtt tttctatcat 3774 tacctctgct ctttgtgaat cagtggatag agatgttact attaccactg gttctaatta 3834 tacactgaaa gggccaccct caggtatgct ttcgtggtat tgctattttg gaactgacac 3894 tgatcaaact gaattatgca attttcaaaa aggcaaaacc tcaaactcta aaatctctaa 3954 ttatcaatgc aatggcactg atctgatact actcaatgtc acgaaagcat atggtggcag 4014 ttattattgc cctggacaaa acactgaaga aatgattttt tacaaagtgg aagtggttga 4074 tcccactaca ccacccacca ccacaactat tcataccaca cacacagaac aaacaccaga 4134 ggcaacagaa gcagagttgg ccttccaggt tcacggagat tcctttgctg tcaatacccc 4194 tacacccgat cagcggtgtc cggggccgct agtcagcggc attgtcggtg tgctttcggg 4254 attagcagtc ataatcatct gcatgttcat ttttgcttgc tgctatagaa ggctttaccg 4314 acaaaaatca gacccactgc tgaacctcta tgtttaattt tttccagagc catgaaggca 4374 gttagcgctc tagttttttg ttctttgatt ggcattgttt ttaatagtaa aattaccaaa 4434 gttagcttta ttaaacatgt taatgtaact gaaggagata acatcacact agcaggtgta 4494 gaaggtgctc aaaacaccac ctggacaaaa taccatctag gatggagaga tatttgcacc 4554 tggaatgtaa cttattattg cataggaatt aatcttacca ttgttaacgc taaccaatct 4614 cagaatgggt taattaaagg acagagtgtt agtgtgacca gtgatgggta ctatacccag 4674 catagtttta actacaacat tactgtcata ccactgccta cgcctagccc acctagcact 4734 accacacaga caaccacata cagtacatca aatcagccta ccaccactac agcagcagag 4794 gttgccagct cgtctggggt ccgagtggca tttttgatgt tggccccatc tagcagtccc 4854 actgctagta ccaatgagca gactactgaa tttttgtcca ctgtcgagag ccacaccaca 4914 gctacctcca gtgccttctc tagcaccgcc aatctctcct cgctttcctc tacaccaatc 4974 agccccgcta ctactcctag ccccgctcct cttcccactc ccctgaagca aacagacggc 5034 ggcatgcaat ggcagatcac cctgctcatt gtgatcgggt tggtcatcct ggccgtgttg 5094 ctctactaca tcttctgccg ccgcattccc aacgcgcacc gcaagccggc ctacaagccc 5154 atcgttatcg ggcagccgga gccgcttcag gtggaagggg gtctaaggaa tcttctcttc 5214 tcttttacag tatggtgatt gaactatgat tcctagacaa ttcttgatca ctattcttat 5274 ctgcctcctc caagtctgtg ccaccctcgc tctggtggcc aacgccagtc cagactgtat 5334 tgggcccttc gcctcctacg tgctctttgc cttcatcacc tgcatctgct gctgtagcat 5394 agtctgcctg cttatcacct tcttccagtt cattgactgg atctttgtgc gcatcgccta 5454 cctgcgccac cacccccagt accgcgacca gcgagtggcg cagctgctca ggctcctctg 5514 ataagcatgc gggctctgct acttctcgcg cttctgctgt tagtgctccc ccgtcccgtt 5574 gacccccggc cccccactca gtcccccgag gaggtccgca aatgcaaatt ccaagaaccc 5634 tggaaattcc tcaaatgcta ccgccaaaaa tcagacatgc atcccagctg gatcatgatc 5694 attgggatcg tgaacattct ggcctgcacc ctcatctcct ttgtgattta cccctgcttt 5754 gactttggtt ggaactcgcc agaggcgctc tatctcccgc ctgaacctga cacaccacca 5814 cagcaacctc aggcacacgc actaccacca ccaccacagc ctaggccaca atacatgccc 5874 atattagact atgaggccga gccacagcga cccatgctcc ccgctattag ttacttcaat 5934 ctaaccggcg gag atg act gac cca ctg gcc aac aac aac gtc aac gac 5983 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp 475 480 ctt ctc ctg gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa 6031 Leu Leu Leu Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln 485 490 495 ctt cgc att cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac 6079 Leu Arg Ile Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp 500 505 510 ggc ata gcc atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa 6127 Gly Ile Ala Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys 515 520 525 530 cag gcc aag atc tcc tac gag gtc acc cag acc gac cat cgc ctc tcc 6175 Gln Ala Lys Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser 535 540 545 tac gag ctc atg cag cag cgc cag aag ttc acc tgc ctg gtc gga gtc 6223 Tyr Glu Leu Met Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val 550 555 560 aac ccc atc gtc atc acc cag cag tcg ggc gat acc aag ggg tgc atc 6271 Asn Pro Ile Val Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile 565 570 575 cac tgc tcc tgc gac tcc ccc gac tgc gtc cac act ctg atc aag acc 6319 His Cys Ser Cys Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr 580 585 590 ctc tgc ggc ctc cgc gac ctc ctc ccc atg aac taatcacc 6360 Leu Cys Gly Leu Arg Asp Leu Leu Pro Met Asn 595 600 605 <210> 122 <211> 188 <212> PRT <213> Simian adenovirus 30 <400> 122 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met Glu 20 25 30 Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu 35 40 45 Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu 165 170 175 Thr Gln Gln Gln Gln Lys Thr Ser Gly Ser Ser Ser 180 185 <210> 123 <211> 106 <212> PRT <213> Simian adenovirus 30 <400> 123 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Ile Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Arg Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 124 <211> 176 <212> PRT <213> Simian adenovirus 30 <400> 124 Met Gly Gln Ile Thr Leu Val Ser Cys Gly Val Leu Val Ala Val Leu 1 5 10 15 Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu Lys Ala 20 25 30 Asp Pro Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Ala His Met Cys Asn Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met 115 120 125 Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 125 <211> 135 <212> PRT <213> Simian adenovirus 30 <400> 125 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Met 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 126 <211> 870 <212> DNA <213> Simian adenovirus 30 <220> <221> CDS <222> (6)..(573) <223> label=Ela <220> <221> CDS <222> (659)..(864) <223> label=Ela <400> 126 gaaag atg agg cac ctg aga gac ctg ccc ggt aat gtt ttc ctg gct act 50 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr 1 5 10 15 ggg aac gag att ctg gaa ctg gtg gtg gac gcc atg atg ggt gac gac 98 Gly Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp 20 25 30 cct ccc gag ccc cct acc cca ttt gag gcg cct tcg ctg tac gat ttg 146 Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu 35 40 45 tat gat ctg gag gtg gat gtg tcc gag aac gac ccc aac gag gag gcg 194 Tyr Asp Leu Glu Val Asp Val Ser Glu Asn Asp Pro Asn Glu Glu Ala 50 55 60 gtg aat gat ttg ttt agc gat gcc gcg ctg ctg gct gcc gag cag gct 242 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala 65 70 75 aat acg gac tct ggc tca gac agc gat tcc tct ctc cat acc ccg aga 290 Asn Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg 80 85 90 95 ccc ggc aga ggt gag aaa aag atc ccc gag ctt aaa ggg gaa gag ctc 338 Pro Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu 100 105 110 gac ctg cgc tgc tat gag gaa tgc ttg cct ccg agc gat gat gag gag 386 Asp Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu 115 120 125 gac gag gag gcg att cga gct gca gcg agc gag gga gtg aaa gtt gcg 434 Asp Glu Glu Ala Ile Arg Ala Ala Ala Ser Glu Gly Val Lys Val Ala 130 135 140 ggc gag agc ttt agc ctg gac tgt cct act ctg ccc gga cac ggc tgt 482 Gly Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys 145 150 155 aag tct tgt gaa ttt cat cgc atg aat act gga gat aag aat gtg atg 530 Lys Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met 160 165 170 175 tgt gcc ctg tgc tat atg aga gct tac aac cat tgt gtt tac a 573 Cys Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr 180 185 gtaagtgtga ttaactttag ttgggaaagg cagagggtga ctgggtgctg actggtttat 633 ttatgtatat gttttttatg tgtag gt ccc gtc tct gac gca gat gag acc 684 Ser Pro Val Ser Asp Ala Asp Glu Thr 195 ccc act tca gag tgc att tca tca ccc cca gaa att ggc gag gaa ccg 732 Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro Glu Ile Gly Glu Glu Pro 200 205 210 ccc gaa gat att att cat aga cca gtt gca gtg aga gtc acc ggg cgg 780 Pro Glu Asp Ile Ile His Arg Pro Val Ala Val Arg Val Thr Gly Arg 215 220 225 230 aga gca gct gtg gag agt ttg gat gac ttg cta cag ggt ggg gat gaa 828 Arg Ala Ala Val Glu Ser Leu Asp Asp Leu Leu Gln Gly Gly Asp Glu 235 240 245 cct ttg gac ttg tgt acc cgg aaa cgc ccc agg cac taagtg 870 Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg His 250 255 <210> 127 <211> 258 <212> PRT <213> Simian adenovirus 30 <400> 127 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Ser Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Ala Ile Arg Ala Ala Ala Ser Glu Gly Val Lys Val Ala Gly 130 135 140 Glu Ser Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val 180 185 190 Ser Asp Ala Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro 195 200 205 Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val Ala 210 215 220 Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp Leu 225 230 235 240 Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro 245 250 255 Arg His <210> 128 <211> 840 <212> DNA <213> Simian adenovirus 30 <220> <221> CDS <222> (8)..(335) <223> label=33K <220> <221> CDS <222> (505)..(839) <223> label=33K <400> 128 ccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 49 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag gag gag 97 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu 15 20 25 30 atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac 145 Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa gca 193 Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg gag gag aaa gca agc agc acg 241 Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 289 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 aga tgg gac gag acc ggg cgc ttc ccg aac ccc acc acc cag acc g 335 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 95 100 105 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 395 gcttgcaagc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 455 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 512 Ala Pro Thr act gtt tcc aag aag agg cag aaa ccc agc agc agc aga aaa cca gcg 560 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 gca gca gca gct aga aaa tcc aca gcg gcg gca ggt gga ctg agg atc 608 Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile 130 135 140 gcg gcg aac gag ccg gcg cag acc cgg gag ctg agg aac cgg atc ttt 656 Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe 145 150 155 160 ccc acc ctc tat gcc atc ttc cag cag agt cgg ggg cag gag cag gaa 704 Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu 165 170 175 ctg aaa gtc aag aac cgt tct ctg cgc tcg ctc acc cgc agt tgt ctg 752 Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu 180 185 190 tat cac aag agc gaa gac caa ctt cag cgc act ctc gag gac gcc gag 800 Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu 195 200 205 gct ctc ttc aac aag tac tgc gcg ctc act ctt aaa gag t 840 Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 129 <211> 221 <212> PRT <213> Simian adenovirus 30 <400> 129 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Pro Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Glu Met Glu 20 25 30 Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser Leu 35 40 45 Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala Ala 50 55 60 Ala Arg Pro Ser Ser Ser Ala Glu Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro Thr 100 105 110 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile 130 135 140 Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe 145 150 155 160 Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu 165 170 175 Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu 180 185 190 Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu 195 200 205 Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 130 <211> 36629 <212> DNA <213> Simian adenovirus 25.2 <220> <221> repeat_region <222> (1)..(126) <223> label=ITR <220> <221> CDS <222> (1905)..(3416) <223> label=Elb\55K <220> <221> CDS <222> (3501)..(3926) <223> label=pIX <220> <221> misc_feature <222> (3990)..(5611) <223> complement (3990..5320, 5599..5611) label=IVa2 <220> <221> misc_feature <222> (5093)..(13834) <223> complement (5093..8665, 13826..13834) label=pol <220> <221> misc_feature <222> (8467)..(13834) <223> complement (8467..10398, 13826..13834) label=pTP <220> <221> CDS <222> (10833)..(12017) <223> label=52K <220> <221> CDS <222> (12044)..(13792) <223> label=pIIIa <220> <221> CDS <222> (13874)..(15466) <223> label=penton <220> <221> CDS <222> (15473)..(16054) <223> label=pVII <220> <221> CDS <222> (16102)..(17145) <223> label=V <220> <221> CDS <222> (17173)..(17403) <223> label=pX <220> <221> CDS <222> (17478)..(18209) <223> label=pVI <220> <221> CDS <222> (18315)..(21113) <223> label=hexon <220> <221> CDS <222> (21136)..(21759) <223> label=protease <220> <221> misc_feature <222> (21845)..(23377) <223> complement label=DBP <220> <221> CDS <222> (23400)..(25790) <223> label=100K <220> <221> CDS <222> (26425)..(27105) <223> label=pVIII <220> <221> CDS <222> (27109)..(27426) <223> label=E3\12.5K <220> <221> CDS <222> (27994)..(28527) <223> label=E3\gp19K <220> <221> CDS <222> (28560)..(29285) <223> label=E3\CR1\beta <220> <221> CDS <222> (29301)..(29906) <223> label=E3\CR1\gamma <220> <221> CDS <222> (29924)..(30784) <223> label=E3\CR1\delta <220> <221> CDS <222> (30795)..(31067) <223> label=E3\RID\alpha <220> <221> CDS <222> (31076)..(31507) <223> label=E3\RID\beta <220> <221> CDS <222> (32207)..(33535) <223> label=fiber <220> <221> misc_feature <222> (33632)..(34782) <223> complement (33632..33880, 34603..34782) label=E4\orf6/7 <220> <221> misc_feature <222> (33880)..(34782) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34691)..(35053) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (35066)..(35416) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35416)..(35802) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35846)..(36217) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36504)..(36629) <223> complement label=ITR <400> 130 catcatcaat aatatacctc aaacttttgg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggat gcggggcgct gattggctgt gacgaaggcg accgttaggg gcggggcggg 120 tgacgttttg atgacgtgtt tgtgaggcgg agccggtttg caagttctcg tgggaaaagt 180 gacgtcaaac gaggtgtggt ttgaacacgg aaatactcaa ttttcccgcg ctctctgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatggc agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtatttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctctag tcaagaggcc actcttgagt gccagcgagt agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 gtaatgtttt cctggctact gggaacgaga ttctggaact ggtggtggac gccatgatgg 660 gtgacgaccc tccggagccc cctaccccat ttgaggcgcc ttcgctgtac gatttgtatg 720 atctggaggt ggatgtgccc gagaacgacc ccaacgagga ggcggtgaat gatttgttta 780 gcgatgccgc gctgctggct gccgagcagg ctaatacgga ctctggctca gacagcgatt 840 cctctctcca taccccgaga cccggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagctcga cctgcgctgc tatgaggaat gcttgcctcc gagcgatgat gaggaggacg 960 aggaggcgat tcgagctgca gcgaaccagg gagtgaaagc ggcgggcgag ggctttagcc 1020 tggactgtcc tactctgccc ggacacggct gtaagtcttg tgaatttcat cgcatgaata 1080 ctggagataa gaatgtgatg tgtgccctgt gctatatgag agcttacaac cattgtgttt 1140 acagtaagtg tgattaactt tagttgggaa ggcagagggt gactgggtgc tgactggttt 1200 atttatgtat atgttttttt atgtgtaggt cccgtctctg acgtagatga gacccccact 1260 tcagagtgca tttcatcacc cccagaaatt ggcgaggaac cgcccgaaga tattattcat 1320 agaccagttg cagtgagagt caccgggcgg agagcagctg tggagagttt ggatgacttg 1380 ctacagggtg gggatgaacc tttggacttg tgtacccgga aacgccccag gcactaagtg 1440 ccacacatgt gtgtttactt aaggtgatgt cagtatttat agggtgtgga gtgcaataaa 1500 atccgtgttg actttaagtg cgtgttttat gactcagggg tggggactgt gggtatataa 1560 gcaggtgcag acctgtgtgg tcagttcaga gcaggactca tggagatctg gacggtcttg 1620 gaagactttc atcagactag acagctgcta gagaactcat cggaggaagt ctcttacctg 1680 tggagatttt gcttcggtgg ggctctagct aagctagtct atagggccaa acaggattat 1740 aaggatcaat ttgaggatat tttgagagag tgtcctggta tttttgactc tctcaacttg 1800 ggccatcagt ctcactttaa ccagagtatt ctgagagccc ttgacttttc tactcctggc 1860 agaactaccg ccgcggtagc cttttttgcc tttatccttg acaa atg gag tca aga 1916 Met Glu Ser Arg 1 aac cca ttt cag cag gga tta ccg tct gga ctg ctt agc agt agc ttt 1964 Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu Ser Ser Ser Phe 5 10 15 20 gtg gag aac atg gag gtg cca gcg cct gaa tgc aat ctc cgg cta ctt 2012 Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu Leu 25 30 35 gcc agt aca gcc ggt aga cac gct gag gat cct gag tct cca gtc acc 2060 Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu Ser Pro Val Thr 40 45 50 cca gga aca cca acg ccg cca gca gcc gca gca gga gca gca gca aga 2108 Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly Ala Ala Ala Arg 55 60 65 gga gga gga gga ccg aga aga gaa ccc gag agc cgg tct gga ccc tcc 2156 Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg Ser Gly Pro Ser 70 75 80 ggt ggc gga gga gga gga gta gct gac ttg ttt ccc gag ctg cgc cgg 2204 Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg 85 90 95 100 gtg ctg act agg tct tcc agt gga cgg gag agg ggg att aag cgg gag 2252 Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu 105 110 115 agg cat gag gag act agc cac aga act gaa ctg act gtc agt ctg atg 2300 Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr Val Ser Leu Met 120 125 130 agc cgc agg cgc cca gaa tcg gtg tgg tgg cat gag gtg cag tcg cag 2348 Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu Val Gln Ser Gln 135 140 145 ggg ata gat gag gtc tca gtg atg cat gag aaa tat tcc cta gaa caa 2396 Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr Ser Leu Glu Gln 150 155 160 gtc aag act tgt tgg ttg gag ccc gag gat gat tgg gag tta gcc atc 2444 Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Leu Ala Ile 165 170 175 180 agg aat tat gcc aag cta gct ctg aag cca gac aag aag tac aag att 2492 Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys Lys Tyr Lys Ile 185 190 195 acc aag ttg att aat atc aga aat tcc tgc tac att tca ggg aat ggg 2540 Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile Ser Gly Asn Gly 200 205 210 gcc gag gtg gag atc agt acc cag gag agg gtg gcc ttc aga tgt tgt 2588 Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala Phe Arg Cys Cys 215 220 225 atg atg aat atg tac ccg ggg gtg gtg ggc atg gag gga gtc acc ttt 2636 Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu Gly Val Thr Phe 230 235 240 atg aac gcg agg ttc agg ggt gat ggg tat aat ggg gtg gtc ttt atg 2684 Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly Val Val Phe Met 245 250 255 260 gcc aac acc aag ctg aca gtg cac gga tgc tcc ttc ttt ggc ttc aat 2732 Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn 265 270 275 aac atg tgc atc gag gcc tgg ggc agt gtt tca gtg agg gga tgc agc 2780 Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val Arg Gly Cys Ser 280 285 290 ttt tca gcc aac tgg atg ggg gtc gtg ggc aga acc aag agc aag gtg 2828 Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Lys Val 295 300 305 tca gtg aag aaa tgc ctg ttc gag agg tgc cac ctg ggg gtg atg agc 2876 Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser 310 315 320 gag ggc gaa gcc aaa gtc aaa cac tgc gcc tct acc gag acg ggc tgc 2924 Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr Glu Thr Gly Cys 325 330 335 340 ttt gtg ctg atc aag ggc aat gcc caa gtc aag cat aac atg atc tgt 2972 Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His Asn Met Ile Cys 345 350 355 ggg gcc tcg gat gag cgc ggc tac cag atg ctg acc tgc gcc ggt ggg 3020 Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly 360 365 370 aac agc cat atg ctg gcc acc gtg cat gtg gcc tcg cac ccc cgc aag 3068 Asn Ser His Met Leu Ala Thr Val His Val Ala Ser His Pro Arg Lys 375 380 385 aca tgg ccc gag ttc gag cac aac gtc atg acc cgc tgc aat gtg cac 3116 Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Val His 390 395 400 ctg ggc tcc cgc cga ggc atg ttc atg ccc tac cag tgc aac atg caa 3164 Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Met Gln 405 410 415 420 ttt gtg aag gtg ctg ctg gag ccc gat gcc atg tcc aga gtg agc ctg 3212 Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu 425 430 435 acg ggg gtg ttt gac atg aat gtg gag ctg tgg aaa att ctg aga tat 3260 Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys Ile Leu Arg Tyr 440 445 450 gat gaa tcc aag acc agg tgc cgg gcc tgc gaa tgc gga ggc aag cac 3308 Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His 455 460 465 gcc agg ctt cag ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc 3356 Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro 470 475 480 gat cat ttg gtg ttg tcc tgc aac ggg acg gag ttc ggc tcc agc ggg 3404 Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe Gly Ser Ser Gly 485 490 495 500 gaa gaa tct gac tagagtgagt agtgcttggg ggaggtggag ggcttgtatg 3456 Glu Glu Ser Asp aggggcagaa tgactaaaat ctgtgttttt ctgtgtgttg cagc atg agc gga agc 3512 Met Ser Gly Ser 505 gcc tcc ttt gag gga ggg gta ttc agc cct tat ctg acg ggg cgt ctc 3560 Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg Leu 510 515 520 ccc tcc tgg gct gga gtg cgt cag aat gtg atg gga tcc acg gtg gac 3608 Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly Ser Thr Val Asp 525 530 535 540 ggc cgg ccc gtg cag ccc gcg aac tct tca acc ctg acc tac gcg acc 3656 Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala Thr 545 550 555 ctg agc tct tcg tcc gtg gac gca gct gcc gcc gca gct gct gct tcc 3704 Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala Ala Ala Ala Ser 560 565 570 gcc gcc agc gcc gtg cgc gga atg gcc ctg ggc gcc ggc tac tac agc 3752 Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala Gly Tyr Tyr Ser 575 580 585 tct ctg gtg gcc aac tcg agt tcc acc aat aat ccc gcc agc ctg aac 3800 Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu Asn 590 595 600 gag gag aag ctg ctg ctg ctg atg gcc cag ctc gag gcc ctg acc cag 3848 Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu Ala Leu Thr Gln 605 610 615 620 cgc ctg ggc gag ctg acc cag cag gtg gct cag ctg cag gcg gag acg 3896 Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu Gln Ala Glu Thr 625 630 635 cgg gcc gcg gtt gcc acg gtg aaa acc aaa taaaaaatga atcaataaat 3946 Arg Ala Ala Val Ala Thr Val Lys Thr Lys 640 645 aaacggagac ggttgttgat tttaacagag tcttgaatct ttatttgatt tttcgcgcgc 4006 ggtaggccct ggaccaccgg tctcgatcat tgagcacccg gtggatcttt tccaggaccc 4066 ggtagaggtg ggcttggatg ttgaggtaca tgggcatgag cccgtcccgg gggtggaggt 4126 agctccattg cagggcctcg tgctcggggg tggtgttgta aatcacccag tcatagcagg 4186 ggcgcagggc gtggtgctgc acgatgtcct tgaggaggag actgatggcc acgggcagcc 4246 ccttggtgta ggtgttgacg aacctgttga gctgggaggg atgcatgcgg ggggagatga 4306 gatgcatctt ggcctggatc ttgagattgg cgatgttccc gcccagatcc cgccgggggt 4366 tcatgttgtg caggaccacc agcacggtgt atccggtgca cttggggaat ttgtcatgca 4426 acttggaagg gaaggcgtga aagaatttgg agacgccctt gtggccgccc aggttttcca 4486 tgcactcatc catgatgatg gcgatgggcc cgtgggcggc ggcctgggca aagacgtttc 4546 gggggtcgga cacatcgtag ttgtggtcct gggtgagctc gtcataggcc attttaatga 4606 atttggggcg gagggtgccc gactggggga cgaaggtgcc ctcgatcccg ggggcgtagt 4666 tgccctcgca gatctgcatc tcccaggcct tgagctcgga gggggggatc atgtccacct 4726 gcggggcgat gaaaaaaacg gtttccgggg cgggggagat gagctgggcc gaaagcaggt 4786 tccggagcag ctgggacttg ccgcagccgg tgggaccgta gatgaccccg atgaccggct 4846 gcaggtggta gttgagggag agacagctgc cgtcctcgcg gaggaggggg gccacctcgt 4906 tcatcatctc gcgcacatgc atgttctcgc gcacgagttc cgccaggagg cgctcgcccc 4966 ccagcgagag gagctcttgc agcgaggcga agtttttcag cggcttgagc ccgtcggcca 5026 tgggcatttt ggagagggtc tgttgcaaga gttccagacg gtcccagagc tcggtgatgt 5086 gctctagggc atctcgatcc agcagacctc ctcgtttcgc gggttggggc gactgcggga 5146 gtagggcacc aggcgatggg cgtccagcga ggccagggtc cggtccttcc agggccgtag 5206 ggtccgcgtc agcgtggtct ccgtcacggt gaaggggtgc gcgccgggct gggcgcttgc 5266 gagggtgcgc ttcaggctca tccggctggt cgagaaccgc tcccggtcgg cgccctgcgc 5326 gtcggccagg tagcaattga gcatgagttc gtagttgagc gcctcggccg cgtggccctt 5386 ggcgcggagc ttacctttgg aagtgtgtcc gcagacggga cagaggaggg acttgagggc 5446 gtagagcttg ggggcgagga agacggactc gggggcgtag gcgtccgcgc cgcagctggc 5506 gcagacggtc tcgcactcca cgagccaggt gaggtcgggg cggtcggggt caaaaacgag 5566 gtttcctccg tgctttttga tgcgtttctt acctctggtc tccatgagct cgtgtccccg 5626 ctgggtgaca aagaggctgt ccgtgtcccc gtagaccgac tttatgggcc ggtcctcgag 5686 cggggtgccg cggtcctcgt cgtagaggaa ccccgcccac tccgagacga aggcccgggt 5746 ccaggccagc acgaaggagg ccacgtggga ggggtagcgg tcgttgtcca ccagcgggtc 5806 caccttctcc agggtatgca agcacatgtc cccctcgtcc acatccagga aggtgattgg 5866 cttgtaagtg taggccacgt gaccgggggt cccggccggg ggggtataaa agggggcggg 5926 cccctgctcg tcctcactgt cttccggatc gctgtccagg agcgccagct gttggggtag 5986 gtattccctc tcgaaggcgg gcatgacctc ggcactcagg ttgtcagttt ctagaaacga 6046 ggaggatttg atattgacgg tgccgttgga gacgcctttc atgagcccct cgtccatctg 6106 gtcagaaaag acgatctttt tgttgtcgag cttggtggcg aaggagccgt agagggcatt 6166 ggagaggagc ttggcgatgg agcgcatggt ctggttcttt tccttgtcgg cgcgctcctt 6226 ggcggcgatg ttgagctgca cgtactcgcg cgccacgcac ttccattcgg ggaagacggt 6286 ggtgagctcg tcgggcacga ttctgacccg ccagccgcgg ttgtgcaggg tgatgaggtc 6346 cacgctggtg gccacctcgc cgcgcagggg ctcgttggtc cagcagaggc gcccgccctt 6406 gcgcgagcag aaggggggca gcgggtccag catgagctcg tcgggggggt cggcgtccac 6466 ggtgaagatg ccgggcagga gctcggggtc gaagtagctg atgcaggtgc ccagatcgtc 6526 cagcgccgct tgccagtcgc gcacggccag cgcgcgctcg taggggctga ggggcgtgcc 6586 ccagggcatg gggtgcgtga gcgcggaggc gtacatgccg cagatgtcgt agacgtagag 6646 gggctcctcg aggacgccga tgtaggtggg gtagcagcgc cccccgcgga tgctggcgcg 6706 cacgtagtcg tacagctcgt gcgagggcgc gaggagcccc gcgccgaggt tggagcgctg 6766 cggcttttcg gcgcggtaga cgatctggcg gaagatggcg tgggagttgg aggagatggt 6826 gggcctctgg aagatgttga agtgggcgtg gggcaggccg accgagtccc tgatgaagtg 6886 ggcgtaggag tcctgcagct tggcgacgag ctcggcggtg acgaggacgt ccagggcgca 6946 gtagtcgagg gtctcttgga tgatgtcgta cttgagctgg cccttctgct tccacagctc 7006 gcggttgaga aggaactctt cgcggtcctt ccagtactct tcgaggggga acccgtcctg 7066 atcggcacgg taagagccca ccatgtagaa ctggttgacg gccttgtagg cgcagcagcc 7126 cttctccacg gggagggcat aagcttgcgc ggccttgcgc agggaggtgt gggtgagggc 7186 gaaggtgtcg cgcaccatga ccttgaggaa ctggtgcttg aagtcgaggt cgtcgcagcc 7246 gccctgctcc cagagttgga agtccgtgcg cttcttgtag gcggggttgg gcaaagcgaa 7306 agtaacatcg ttgaagagga tcttgcccgc gcggggcatg aagttgcgag tgatgcggaa 7366 aggctggggc acctcggccc ggttgttgat gacctgggcg gcgaggacga tctcgtcgaa 7426 gccgttgatg ttgtgcccga cgatgtagag ttccacgaat cgcgggcggc ccttgacgtg 7486 gggcagcttc ttgagctcgt cgtaggtgag ctcggcgggg tcgctgaggc cgtgctgctc 7546 aagggcccag tcggcgacgt gggggttggc gctgaggaag gaagtccaga gatccacggc 7606 cagggcggtt tgcaagcggt cccggtactg acggaactgc tggcccacgg ccattttttc 7666 gggggtgatg cagtagaagg tgcgggggtc gccgtgccag cggtcccact tgagctggag 7726 ggcgaggtcg tgggcgagct cgacgagcgg cgggtccccg gagagtttca tgaccagcat 7786 gaaggggacg agctgcttgc cgaaggaccc catccaggtg taggtttcca catcgtaggt 7846 gaggaagagc ctttcggtgc gaggatgcga gccgatgggg aagaactgga tctcctgcca 7906 ccagttggag gaatggctgt tgatgtgatg gaagtagaaa tgccgacggc gcgccgagca 7966 ctcgtgcttg tgtttataca agcgtccgca gtgctcgcaa cgctgcacgg gatgcacgtg 8026 ctgcacgagc tgtacctggg ttcctttgac gaggaatttc agtgggcagt ggagcgctgg 8086 cggctgcatc tggtgctgta ctacgtcctg gccatcggcg tggccatcgt ctgcctcgat 8146 ggtggtcatg ctgacgagcc cgcgcgggag gcaggtccag acctcggctc ggacgggtcg 8206 gagagcgagg acgagggcgc gcaggccgga gctgtccagg gtcctgagac gctgcggagt 8266 caggtcagtg ggcagcggcg gcgcgcggtt gacttgcagg agcttttcca gggcgcgcgg 8326 gaggtccaga tggtacttga tctccacggc gccgttggtg gcgacgtcca cggcttgcag 8386 ggtcccgtgc ccctggggcg ccaccaccgt gccccgtttc ttcttgggcg ctggcgttgg 8446 cgctgcttcc atgtcggtca gaagcggcgg cgaggacgcg cgccgggcgg caggggcggc 8506 tcggggcccg gaggcagggg cggcaggggc acgtcggcgc cgcgcgcggg caggttctgg 8566 tactgcgccc ggagaagact ggcgtgagcg acgacgcgac ggttgacgtc ctggatctga 8626 cgcctctggg tgaaggccac gggacccgtg agtttgaacc tgaaagagag ttcgacagaa 8686 tcaatctcgg tatcgttgac ggcggcctgc cgcaggatct cttgcacgtc gcccgagttg 8746 tcctggtagg cgatctcggt catgaactgc tcgatctcct cctcctgaag gtctccgcgg 8806 ccggcgcgct cgacggtggc cgcgaggtcg ttggagatgc ggcccatgag ctgcgagaag 8866 gcgttcatgc cggcctcgtt ccagacgcgg ctgtagacca cggctccgtc ggggtcgcgc 8926 gcgcgcatga ccacctgggc gaggttgagc tcgacgtggc gcgtgaagac cgcgtagttg 8986 cagaggcgct ggtagaggta gttgagcgtg gtggcgatgt gctcggtgac gaagaagtac 9046 atgatccagc ggcggagcgg catctcgctg acgtcgccca gggcttccaa gcgctccatg 9106 gcctcgtaga agtccacggc gaagttgaaa aactgggagt tgcgcgccga gacggtcaac 9166 tcctcctcca gaagacggat gagctcggcg atggtggcgc gcacttcgcg ctcgaaggcc 9226 ccggggggct cctcctcttc catctcctcc tcttcctcct cctccactaa catctcttct 9286 acttcctcct caggaggcgg cggcggggga gggggcctgc gtcgccggcg gcgcacgggc 9346 agacggtcga tgaagcgctc gatggtctcc ccgcgccggc gacgcatggt ctcggtgacg 9406 gcgcgcccgt cctcgcgggg ccgcagcgtg aagacgccgc cgcgcatttc caggtggccg 9466 ggggggtccc cgttgggcag ggagagggcg ctgacgatgc atcttatcaa ttgccccgta 9526 gggactccgc gcaaggacct gagcgtctcg agatccacgg gatctgaaaa ccgttgaacg 9586 aaggcttcga gccagtcgca gtcgcaaggt aggctgagca cggtttcttc tggcgggtca 9646 tgttggggag cggggcgggc gatgctgctg gtgatgaagt tgaaataggc ggttctgaga 9706 cggcggatgg tggcgaggag caccaggtct ttgggcccgg cttgctggat gcgcagacgg 9766 tcggccatgc cccaggcgtg gtcctgacac ctggccagat ccttgtagta gtcctgcatg 9826 agccgctcca cgggcacctc ctcctcgccc gcgcggccgt gcatgcgcgt gagcccgaag 9886 ccgcgctggg gctggacgag cgccaggtcg gcgacgacgc gctcggcgag gatggcctgc 9946 tggatctggg tgagggtggt ctggaagtcg tcaaagtcga cgaagcggtg gtaggctccg 10006 gtgttgatgg tgtaggagca gttggccatg acggaccagt tgacggtctg gtggccggga 10066 cgcacgagct cgtggtactt gaggcgcgag taggcgcgcg tgtcgaagat gtagtcgttg 10126 caggtgcgca ccaggtactg gtagccgatg aggaagtgcg gcggcggctg gcggtagagc 10186 ggccatcgct cggtggcggg ggcgccgggc gcgaggtcct cgagcatggt gcggtggtag 10246 ccgtagatgt acctggacat ccaggtgatg ccggcggcgg tggtggaggc gcgcgggaac 10306 tcgcggacgc ggttccagat gttgcgcagc ggcaggaagt agttcatggt gggcacggtc 10366 tggcccgtga ggcgcgcgca gtcgtggatg ctctatacgg gcaaaaacga aagcggtcag 10426 cggctcgact ccgtggcctg gaggctaagc gaacgggttg ggctgcgcgt gtaccccggt 10486 tcgaatctcg aatcaggctg gagccgcagc taacgtggta ctggcactcc cgtctcgacc 10546 caagcctgca ccaaccctcc aggatacgga ggcgggtcgt ttttgcaact ttttttcgga 10606 ggccggaaat gaagactagt aagcgcggaa agcggccgac cgcgatggct cgctgccgta 10666 gtctggagaa gaatcgccag ggttgcgttg cggtgtgccc cggttcgagg ccggccggat 10726 tccgcggcta acgagggcgt ggctgccccg tcgtttccaa gacccctagc cagccgactt 10786 ctccagttac ggagcgagcc cctcttttgt tttttgtttt tgccag atg cat ccc 10841 Met His Pro gta ctg cgg cag atg cgc ccc cac cac cct cca ccg caa caa cag ccc 10889 Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro 650 655 660 665 cct cct cca cag ccg gcg ctt ctg ccc ccg ccc cag cag cag cag caa 10937 Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln 670 675 680 ctt cca gcc acg acc gcc gcg gcc gcc gtg agc ggg gct gga cag act 10985 Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Thr 685 690 695 tct cag tat gat cac ctg gcc ttg gaa gag ggc gag ggg ctg gcg cgc 11033 Ser Gln Tyr Asp His Leu Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg 700 705 710 ctg ggg gcg tcg tcg ccg gag cgg cac ccg cgc gtg cag atg aaa agg 11081 Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln Met Lys Arg 715 720 725 gac gct cgc gag gcc tac gtg ccc aag cag aac ctg ttc aga gac agg 11129 Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe Arg Asp Arg 730 735 740 745 agc ggc gag gag ccc gag gag atg cgc gcg gcc cgg ttc cac gcg ggg 11177 Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe His Ala Gly 750 755 760 cgg gag ctg cgg cgc ggc ctg gac cga aag agg gtg ctg agg gac gag 11225 Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu Arg Asp Glu 765 770 775 gat ttc gag gcg gac gag ctg acg ggg atc agc ccc gcg cgc gcg cac 11273 Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala Arg Ala His 780 785 790 gtg gcc gcg gcc aac ctg gtc acg gcg tac gag cag acc gtg aag gag 11321 Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr Val Lys Glu 795 800 805 gag agc aac ttc caa aaa tcc ttc aac aac cac gtg cgc acc ctg atc 11369 Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg Thr Leu Ile 810 815 820 825 gcg cgc gag gag gtg acc ctg ggc ctg atg cac ctg tgg gac ctg ctg 11417 Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp Asp Leu Leu 830 835 840 gag gcc atc gtg cag aac ccc acc agc aag ccg ctg acg gcg cag ctg 11465 Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu 845 850 855 ttc ctg gtg gtg cag cat agt cgg gac aac gag gcg ttc agg gag gcg 11513 Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe Arg Glu Ala 860 865 870 ctg ctg aat atc acc gag ccc gag ggc cgc tgg ctc ctg gac ctg gtg 11561 Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu Asp Leu Val 875 880 885 aac att ctg cag agc atc gtg gtg cag gag cgc ggg ctg ccg ctg tcc 11609 Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu Pro Leu Ser 890 895 900 905 gag aag ctg gcg gcc atc aac ttc tcg gtg ctg agt ctg ggc aag tac 11657 Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr 910 915 920 tac gct agg aag atc tac aag acc ccg tac gtg ccc ata gac aag gag 11705 Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu 925 930 935 gtg aag atc gac ggg ttt tac atg cgc atg acc ctg aaa gtg ctg acc 11753 Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys Val Leu Thr 940 945 950 ctg agc gac gat ctg ggg gtg tac cgc aac gac agg atg cac cgc gcg 11801 Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala 955 960 965 gtg agc gcc agc agg cgg cgc gag ctg agc gac cag gag ctg atg cac 11849 Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His 970 975 980 985 agc ctg cag cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc tac 11897 Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr 990 995 1000 ttt gac atg ggc gcg gac ctg cac tgg caa ccc agc cgc cgg gcc 11942 Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala 1005 1010 1015 ttg gag gcg gcg gca gga ccc tac gta gaa gag gtg gac gat gag 11987 Leu Glu Ala Ala Ala Gly Pro Tyr Val Glu Glu Val Asp Asp Glu 1020 1025 1030 gtg gac gag gag ggc gag tac ctg gaa gac tgatggcgcg accgtatttt 12037 Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 1035 1040 tgctag atg caa caa cag cca cct cct gat ccc gcg atg cgg gcg gcg 12085 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala 1045 1050 1055 ctg cag agc cag ccg tcc ggc att aac tcc tcg gac gat tgg acc 12130 Leu Gln Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr 1060 1065 1070 cag gcc atg caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa 12175 Gln Ala Met Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu 1075 1080 1085 gcc ttt aga cag cag ccc cag gcc aac cgg ctc tcg gcc atc ctg 12220 Ala Phe Arg Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu 1090 1095 1100 gag gcc gtg gtg ccc tcg cgc tcc aac ccc acg cac gag aag gtc 12265 Glu Ala Val Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val 1105 1110 1115 ctg gcc atc gtg aac gcg ctg gtg gag aac aag gcc atc cgc ggc 12310 Leu Ala Ile Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly 1120 1125 1130 gac gag gcc ggc ctg gtg tac aac gcg ctg ctg gag cgc gtg gcc 12355 Asp Glu Ala Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala 1135 1140 1145 cgc tac aac agc acc aac gtg cag acc aac ctg gac agg atg gtg 12400 Arg Tyr Asn Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val 1150 1155 1160 acc gac gtg cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc 12445 Thr Asp Val Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg 1165 1170 1175 gag tcc aac ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc 12490 Glu Ser Asn Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser 1180 1185 1190 acc cag ccc gcc aac gtg ccc cgg ggc cag gag gac tac acc aac 12535 Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn 1195 1200 1205 ttc atc agc gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc 12580 Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser 1210 1215 1220 gag gtg tac cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc 12625 Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg 1225 1230 1235 cag ggc ttg cag acc gtg aac ctg agc cag gcg ttc aag aac ttg 12670 Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu 1240 1245 1250 cag ggc ctg tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg 12715 Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 1255 1260 1265 gtg tcg agc ctg ctg acg ccg aac tcg cgc ctg ctg ctg ctg ctg 12760 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu 1270 1275 1280 gtg gcc ccc ttc acg gac agc ggc agt atc aac cgc gac tcg tac 12805 Val Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asp Ser Tyr 1285 1290 1295 ctg ggc tac ctg att aac ctg tac cgc gag gcc atc ggc cag gcg 12850 Leu Gly Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala 1300 1305 1310 cac gtg gac gag cag acc tac cag gag atc acc cac gtg agc cgc 12895 His Val Asp Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg 1315 1320 1325 gcg ctg ggc cag gag gac ccg ggc aac ctg gag gcc acc ctg aac 12940 Ala Leu Gly Gln Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn 1330 1335 1340 ttc ctg ctg acc aac cgg tcg cag aag atc ccg ccc cag tac gcg 12985 Phe Leu Leu Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala 1345 1350 1355 ctg agc acc gag gag gag cgc att ttg cgc tac gtg cag cag agc 13030 Leu Ser Thr Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser 1360 1365 1370 gtg ggg ctg ttc ctg atg cag gag ggg gcc acg ccc agc gcc gcg 13075 Val Gly Leu Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala 1375 1380 1385 ctc gac atg acc gcg cgc aac atg gag ccc agc atg tac gcc cgc 13120 Leu Asp Met Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Arg 1390 1395 1400 aac cgc ccg ttc atc aat aag ctg atg gac tac ttg cat cgg gcg 13165 Asn Arg Pro Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala 1405 1410 1415 gcc gcc atg aac tcg gac tac ttt acc aac gcc atc ttg aac ccg 13210 Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro 1420 1425 1430 cac tgg ctc ccg ccg ccc ggg ttc tac acg ggc gag tac gac atg 13255 His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met 1435 1440 1445 ccc gac ccc aac gac ggg ttc ctg tgg gat gac gtg gac agc agc 13300 Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser 1450 1455 1460 gtg ttc tcg ccg cgc ccc gcc acc acc gtg tgg aag aaa gag ggc 13345 Val Phe Ser Pro Arg Pro Ala Thr Thr Val Trp Lys Lys Glu Gly 1465 1470 1475 ggg gac cgg cgg ccg tcc tcg gcg ctg tcc ggt cgc gcg ggt gct 13390 Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala Gly Ala 1480 1485 1490 gcc gcg gcg gtg ccc gag gcc gcc agt ccg ttc ccg agc ttg ccc 13435 Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro 1495 1500 1505 ttc tcg ctg aac agt att cgc agc agc gag ctg ggc agg atc acg 13480 Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr 1510 1515 1520 cgc ccg cgc ttg ctg ggc gag gag gag tac ttg aat gac tcg ctg 13525 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu 1525 1530 1535 ttg aga ccc gag cgc gag aag aac ttc ccc aat aac ggg ata gag 13570 Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 1540 1545 1550 agc ctg gtg gac aag atg agc cgc tgg aag acg tac gcg cac gag 13615 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu 1555 1560 1565 cac agg gac gag ccc cga gct agc agc gcc acc cgt aga cgc cag 13660 His Arg Asp Glu Pro Arg Ala Ser Ser Ala Thr Arg Arg Arg Gln 1570 1575 1580 cgg cac gac agg cag cgg gga ctg gtg tgg gac gat gag gat tcc 13705 Arg His Asp Arg Gln Arg Gly Leu Val Trp Asp Asp Glu Asp Ser 1585 1590 1595 gcc gac gac agc agc gtg ttg gac ttg ggt ggg agt ggt ggt ggt 13750 Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser Gly Gly Gly 1600 1605 1610 aac ccg ttc gct cac ctg cgt ccc cgt atc ggg cgc ctg atg 13792 Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Leu Met 1615 1620 taagaatctg aaaaaataaa aaacggtact caccaaggcc atggcgacca gcgtgcgttc 13852 ttctctgttg tttgtagtag t atg atg agg cgc gtg tac ccg gag ggt cct 13903 Met Met Arg Arg Val Tyr Pro Glu Gly Pro 1625 1630 cct ccc tcg tac gag agc gtg atg cag cag gcg gtg gcg gcg gcg 13948 Pro Pro Ser Tyr Glu Ser Val Met Gln Gln Ala Val Ala Ala Ala 1635 1640 1645 atg cag ccc ccg ctg gag gcg cct tac gtg ccc ccg cgg tac ctg 13993 Met Gln Pro Pro Leu Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu 1650 1655 1660 gcg cct acg gag ggg cgg aac agc att cgt tac tcg gag ctg gca 14038 Ala Pro Thr Glu Gly Arg Asn Ser Ile Arg Tyr Ser Glu Leu Ala 1665 1670 1675 ccc ttg tac gat acc acc cgg ttg tac ctg gtg gac aac aag tcg 14083 Pro Leu Tyr Asp Thr Thr Arg Leu Tyr Leu Val Asp Asn Lys Ser 1680 1685 1690 gcg gac atc gcc tcg ctg aac tac cag aac gac cac agc aac ttc 14128 Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn Asp His Ser Asn Phe 1695 1700 1705 ctg acc acc gtg gtg cag aac aac gat ttc acc ccc acg gag gcc 14173 Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr Pro Thr Glu Ala 1710 1715 1720 agc acc cag acc atc aac ttt gac gag cgc tcg cgg tgg ggc ggc 14218 Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg Trp Gly Gly 1725 1730 1735 cag ctg aaa acc atc atg cac acc aac atg ccc aac gtg aac gag 14263 Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val Asn Glu 1740 1745 1750 ttc atg tac agc aac aag ttc aag gcg cgg gtg atg gtc tcg cgc 14308 Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser Arg 1755 1760 1765 aag acc ccc aac ggg gtg acg gta ggg gat gat tat gat ggt agt 14353 Lys Thr Pro Asn Gly Val Thr Val Gly Asp Asp Tyr Asp Gly Ser 1770 1775 1780 cag gac gag ctg acc tac gag tgg gtg gag ttt gag ctg ccc gag 14398 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu 1785 1790 1795 ggc aac ttc tcg gtg acc atg acc atc gat ctg atg aac aac gcc 14443 Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala 1800 1805 1810 atc atc gac aac tac ttg gcg gtg ggg cgg cag aac ggg gtg ctg 14488 Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu 1815 1820 1825 gag agc gac atc ggc gtg aag ttc gac acg cgc aac ttc cgg ctg 14533 Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu 1830 1835 1840 ggc tgg gac ccc gtg acc gag ctg gtg atg ccg ggc gtg tac acc 14578 Gly Trp Asp Pro Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr 1845 1850 1855 aac gag gcc ttc cac ccc gac atc gtc ctg ctg ccc ggc tgc ggc 14623 Asn Glu Ala Phe His Pro Asp Ile Val Leu Leu Pro Gly Cys Gly 1860 1865 1870 gtg gac ttc acc gag agc cgc ctc agc aac ctg ctg ggc atc cgc 14668 Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu Leu Gly Ile Arg 1875 1880 1885 aag cgg cag ccc ttc cag gag ggc ttc cag atc ctg tac gag gac 14713 Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln Ile Leu Tyr Glu Asp 1890 1895 1900 ctg gag ggg ggc aac atc ccc gcg ctg ctg gat gtg gac gcc tac 14758 Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp Val Asp Ala Tyr 1905 1910 1915 gag aaa agc aag gag gat agc gcc gcc gcg gcg acc gca gcc gtg 14803 Glu Lys Ser Lys Glu Asp Ser Ala Ala Ala Ala Thr Ala Ala Val 1920 1925 1930 gcc acc gcc tct acc gag gtg cgg ggc gat aat ttt gct agc gcc 14848 Ala Thr Ala Ser Thr Glu Val Arg Gly Asp Asn Phe Ala Ser Ala 1935 1940 1945 gcg gca gtg gcc gag gcg gct gaa acc gaa agt aag ata gtg atc 14893 Ala Ala Val Ala Glu Ala Ala Glu Thr Glu Ser Lys Ile Val Ile 1950 1955 1960 cag ccg gtg gag aag gac agc aag aac agg agc tac aac gtg ctc 14938 Gln Pro Val Glu Lys Asp Ser Lys Asn Arg Ser Tyr Asn Val Leu 1965 1970 1975 gcg gac aag aaa aac acc gcc tac cgc agc tgg tac ctg gcc tac 14983 Ala Asp Lys Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala Tyr 1980 1985 1990 aac tac ggc gac ccc gag aag ggc gtg cgc tcc tgg acg ctg ctc 15028 Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu 1995 2000 2005 acc acc tcg gac gtc acc tgc ggc gtg gag caa gtc tac tgg tcg 15073 Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser 2010 2015 2020 ctg ccc gac atg atg caa gac ccg gtc acc ttc cgc tcc acg cga 15118 Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg 2025 2030 2035 caa gtt agc aac tac ccg gtg gtg ggc gcc gag ctc ctg ccc gtc 15163 Gln Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val 2040 2045 2050 tac tcc aag agc ttc ttc aac gag cag gcc gtc tac tcg cag cag 15208 Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln 2055 2060 2065 ctg cgc gcc ttc acc tcg ctc acg cac gtc ttc aac cgc ttc ccc 15253 Leu Arg Ala Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro 2070 2075 2080 gag aac cag atc ctc gtt cgc ccg ccc gcg ccc acc att acc acc 15298 Glu Asn Gln Ile Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr 2085 2090 2095 gtc agt gaa aac gtt cct gct ctc aca gat cac ggg acc ctg ccg 15343 Val Ser Glu Asn Val Pro Ala Leu Thr Asp His Gly Thr Leu Pro 2100 2105 2110 ctg cgc agc agt atc cgg gga gtc cag cgc gtg acc gtc act gac 15388 Leu Arg Ser Ser Ile Arg Gly Val Gln Arg Val Thr Val Thr Asp 2115 2120 2125 gcc aga cgc cgc acc tgc ccc tac gtc tac aag gcc ctg ggc gta 15433 Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr Lys Ala Leu Gly Val 2130 2135 2140 gtc gcg ccg cgc gtc ctc tcg agc cgc acc ttc taaaaa atg tcc att 15481 Val Ala Pro Arg Val Leu Ser Ser Arg Thr Phe Met Ser Ile 2145 2150 2155 ctc atc tcg ccc agt aat aac acc ggt tgg ggc ctg cgc gcg ccc 15526 Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg Ala Pro 2160 2165 2170 agc aag atg tac gga ggc gct cgc caa cgc tcc acg caa cac ccc 15571 Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His Pro 2175 2180 2185 gtg cgc gtg cgc ggg cac ttc cgc gct ccc tgg ggc gcc ctc aag 15616 Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 2190 2195 2200 ggc cgc gtg cgc tcg cgc acc acc gtc gac gac gtg atc gac cag 15661 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln 2205 2210 2215 gtg gtg gcc gac gcg cgc aac tac acg ccc gcc gcc gcg ccc gtc 15706 Val Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val 2220 2225 2230 tcc acc gtg gac gcc gtc atc gac agc gtg gtg gcc gac gcg cgc 15751 Ser Thr Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg 2235 2240 2245 cgg tac gcc cgc gcc aag agc cgg cgg cgg cgc atc gcc cgg cgg 15796 Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg 2250 2255 2260 cac cgg agc acc ccc gcc atg cgc gcg gca cga gcc ttg ctg cgc 15841 His Arg Ser Thr Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg 2265 2270 2275 agg gcc agg cgc acg gga cgc agg gcc atg ctc agg gcg gcc aga 15886 Arg Ala Arg Arg Thr Gly Arg Arg Ala Met Leu Arg Ala Ala Arg 2280 2285 2290 cgc gcg gcc tcc ggc agc agc agc gcc ggc agg acc cgc aga cgc 15931 Arg Ala Ala Ser Gly Ser Ser Ser Ala Gly Arg Thr Arg Arg Arg 2295 2300 2305 gcg gcc acg gcg gcg gcg gcg gcc atc gcc agc atg tcc cgc ccg 15976 Ala Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser Met Ser Arg Pro 2310 2315 2320 cgg cgc ggc aac gtg tac tgg gtg cgc gac gcc gcc acc ggt gtg 16021 Arg Arg Gly Asn Val Tyr Trp Val Arg Asp Ala Ala Thr Gly Val 2325 2330 2335 cgc gtg ccc gtg cgc acc cgc ccc cct cgc act tgaagatgct 16064 Arg Val Pro Val Arg Thr Arg Pro Pro Arg Thr 2340 2345 gacttcgcga tgttgatgtg tcccagcggc gaggagg atg tcc aag cgc aaa 16116 Met Ser Lys Arg Lys 2350 tac aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac ggc 16161 Tyr Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr Gly 2355 2360 2365 ccc gcg gtg gtg aag gag gaa aga aag ccc cgc aaa ctg aag cgg 16206 Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys Leu Lys Arg 2370 2375 2380 gtc aaa aag gac aaa aag gag gag gaa gat gac gga ctg gtg gag 16251 Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly Leu Val Glu 2385 2390 2395 ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg 16296 Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly 2400 2405 2410 cgg aaa gtg aaa ccg gtg ctg cga ccc ggc acc acg gtg gtc ttc 16341 Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe 2415 2420 2425 acg ccc ggc gag cgt tcc ggc tcc gcc tcc aag cgc tcc tac gac 16386 Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp 2430 2435 2440 gag gtg tac ggg gac gag gac atc ctc gag cag gcg gtc gag cgt 16431 Glu Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Val Glu Arg 2445 2450 2455 ctg ggc gag ttt gct tac ggc aag cgc agc cgc ccc gcg ccc ttg 16476 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu 2460 2465 2470 aaa gag gag gcg gtg tcc atc ccg ctg gac cac ggc aac ccc acg 16521 Lys Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr 2475 2480 2485 ccg agc ctg aag ccg gtg acc ctg cag cag gtg ctg ccg agc gcg 16566 Pro Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala 2490 2495 2500 gcg ccg cgc cgg ggc ttc aag cgc gag ggc ggc gag gat ctg tac 16611 Ala Pro Arg Arg Gly Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr 2505 2510 2515 ccg acc atg cag ctg atg gtg ccc aag cgc cag aag ctg gag gac 16656 Pro Thr Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp 2520 2525 2530 gtg ctg gag cac atg aag gtg gac ccc gag gtg cag ccc gag gtc 16701 Val Leu Glu His Met Lys Val Asp Pro Glu Val Gln Pro Glu Val 2535 2540 2545 aag gtg cgg ccc atc aag cag gtg gcc ccg ggc ctg ggc gtg cag 16746 Lys Val Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln 2550 2555 2560 acc gtg gac atc aag atc ccc acg gag ccc atg gaa acg cag acc 16791 Thr Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr 2565 2570 2575 gag ccc gtg aag ccc agc acc agc acc atg gag gtg cag acg gat 16836 Glu Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp 2580 2585 2590 ccc tgg atg ccc gcg gct ccc acc acc acc act cgc cga aga cgc 16881 Pro Trp Met Pro Ala Ala Pro Thr Thr Thr Thr Arg Arg Arg Arg 2595 2600 2605 aag tac ggc gcg gcc agc ctg ctg atg ccc aac tac gcg ctg cat 16926 Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu His 2610 2615 2620 cct tcc atc atc ccc acg ccg ggc tac cgc ggc acg cgc ttc tac 16971 Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr 2625 2630 2635 cgc ggc tac acc agc agc cgc cgc cgc aag acc acc acc cgc cgc 17016 Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg 2640 2645 2650 cgc cgc cgt cgc cac acc cgc cgc agc agc acc gcg act tcc gcc 17061 Arg Arg Arg Arg His Thr Arg Arg Ser Ser Thr Ala Thr Ser Ala 2655 2660 2665 gcc gcc ttg gtg cgg aga gtg tac cgc agc ggg cgc gag cct ctg 17106 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu 2670 2675 2680 acc ctg ccg cgc gcg cgc tac cac ccg agc atc gcc att taactctgcc 17155 Thr Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 2685 2690 2695 gtcgcctcct tgcagat atg gcc ctc aca tgc cgc ctc cgc gtc ccc att 17205 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile 2700 2705 acg ggc tac cga gga aga aag ccg cgc cgt aga agg ctg acg ggg 17250 Thr Gly Tyr Arg Gly Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly 2710 2715 2720 aac ggg ctg cgt cgc cat cac cac cgg cgg cgg cgc gcc atc agc 17295 Asn Gly Leu Arg Arg His His His Arg Arg Arg Arg Ala Ile Ser 2725 2730 2735 aag cgg ttg ggg gga ggc ttc ctg ccc gcg ctg atc ccc atc atc 17340 Lys Arg Leu Gly Gly Gly Phe Leu Pro Ala Leu Ile Pro Ile Ile 2740 2745 2750 gcc gcg gcg atc ggg gcg atc ccc ggc ata gct tcc gtg gcg gtg 17385 Ala Ala Ala Ile Gly Ala Ile Pro Gly Ile Ala Ser Val Ala Val 2755 2760 2765 cag gcc tct cag cgc cac tgagacacaa aaaagcatgg atttgtaata 17433 Gln Ala Ser Gln Arg His 2770 aaaaaatgga ctgacgctcc tggtcctgtg atgtgtgttt ttag atg gaa gac atc 17489 Met Glu Asp Ile 2775 aat ttt tcg tcc ctg gca ccg cga cac ggc acg cgg ccg ttt atg 17534 Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met 2780 2785 2790 ggc acc tgg agc gac atc ggc aac agc caa ctg aac ggg ggc gcc 17579 Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly Gly Ala 2795 2800 2805 ttc aat tgg agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc 17624 Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 2810 2815 2820 acg ctc aaa acc tat ggc aac aag gcg tgg aac agc agc aca ggg 17669 Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 2825 2830 2835 cag gcg ctg agg gaa aag ctg aaa gag cag aac ttc cag cag aag 17714 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys 2840 2845 2850 gtg gtc gat ggc ctg gcc tcg ggc atc aac ggg gtg gtg gac ctg 17759 Val Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu 2855 2860 2865 gcc aac cag gcc gtg cag aaa cag atc aac agc cgc ctg gac gcg 17804 Ala Asn Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala 2870 2875 2880 gtc ccg ccc gcg ggc tcc gtg gag atg ccc cag gtg gag gag gag 17849 Val Pro Pro Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu 2885 2890 2895 ctg cct ccc ctg gac aag cgc ggc gac aag cga ccg cgt ccc gac 17894 Leu Pro Pro Leu Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp 2900 2905 2910 gcg gag gag acg ctg ctg acg cac acg gac gag ccg ccc ccg tac 17939 Ala Glu Glu Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr 2915 2920 2925 gag gag gcg gtg aaa ctg ggt ctg ccc acc acg cgg ccc atc gcg 17984 Glu Glu Ala Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala 2930 2935 2940 ccc ctg gcc acc ggg gtg ctg aaa ccc gaa agt aat aag ccc gcg 18029 Pro Leu Ala Thr Gly Val Leu Lys Pro Glu Ser Asn Lys Pro Ala 2945 2950 2955 acc ctg gac ttg cct cct ccc cag cct tcc cgc ccc tcc aca gtg 18074 Thr Leu Asp Leu Pro Pro Pro Gln Pro Ser Arg Pro Ser Thr Val 2960 2965 2970 gct aag ccc ctg ccg ccg gtg gcc gtg gcc cgc gcg cga ccc ggg 18119 Ala Lys Pro Leu Pro Pro Val Ala Val Ala Arg Ala Arg Pro Gly 2975 2980 2985 ggc acc gcc cgc cct cat gcg aac tgg cag agc act ctg aac agc 18164 Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser Thr Leu Asn Ser 2990 2995 3000 atc gtg ggt ctg gga gtg cag agt gtg aag cgc cgc cgc tgc tat 18209 Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 3005 3010 3015 taaacctacc gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc 18269 tgtcgccaga aggaggagtg aagaggcgcg tcgccgagtt gcaag atg gcc acc 18323 Met Ala Thr 3020 cca tcg atg ctg ccc cag tgg gcg tac atg cac atc gcc gga cag 18368 Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala Gly Gln 3025 3030 3035 gac gct tcg gag tac ctg agt ccg ggt ctg gtg cag ttt gcc cgc 18413 Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg 3040 3045 3050 gcc aca gac acc tac ttc agt ctg ggg aac aag ttt agg aac ccc 18458 Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 3055 3060 3065 acg gtg gcg ccc acg cac gat gtg acc acc gac cgc agc cag cgg 18503 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg 3070 3075 3080 ctg acg ctg cgc ttc gtg ccc gtg gac cgc gag gac aac acc tac 18548 Leu Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr 3085 3090 3095 tcg tac aaa gtg cgc tac acg ctg gcc gtg ggc gac aac cgc gtg 18593 Ser Tyr Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val 3100 3105 3110 ctg gac atg gcc agc acc tac ttt gac atc cgg ggc gtg ctg gac 18638 Leu Asp Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp 3115 3120 3125 cgg ggc cct agc ttc aaa ccc tac tcc ggc acc gcc tac aac agc 18683 Arg Gly Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser 3130 3135 3140 ctg gcc ccc aag gga gca ccc aac act tgt cag tgg aca tat aaa 18728 Leu Ala Pro Lys Gly Ala Pro Asn Thr Cys Gln Trp Thr Tyr Lys 3145 3150 3155 gcc gat ggt gaa act gcc aca gaa aaa acc tat aca tat gga aat 18773 Ala Asp Gly Glu Thr Ala Thr Glu Lys Thr Tyr Thr Tyr Gly Asn 3160 3165 3170 gca ccc gtg cag ggc att aac atc aca aaa gat ggt att caa ctt 18818 Ala Pro Val Gln Gly Ile Asn Ile Thr Lys Asp Gly Ile Gln Leu 3175 3180 3185 gga act gac acc gat gat cag cca atc tat gca gat gaa acc tat 18863 Gly Thr Asp Thr Asp Asp Gln Pro Ile Tyr Ala Asp Glu Thr Tyr 3190 3195 3200 cag cct gaa cct caa gtg ggt gat gct gaa tgg cat gac atc act 18908 Gln Pro Glu Pro Gln Val Gly Asp Ala Glu Trp His Asp Ile Thr 3205 3210 3215 ggt act gat gaa aag tat gga ggc aga gct ctt aag cct gat acc 18953 Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala Leu Lys Pro Asp Thr 3220 3225 3230 aaa atg aag cct tgt tat ggt tct ttt gcc aag cct act aat aaa 18998 Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Lys 3235 3240 3245 gaa gga ggt cag gca aat gtg aaa aca gga aca ggc act act aaa 19043 Glu Gly Gly Gln Ala Asn Val Lys Thr Gly Thr Gly Thr Thr Lys 3250 3255 3260 gaa tat gac ata gac atg gct ttc ttt gac aac aga agt gcg gcc 19088 Glu Tyr Asp Ile Asp Met Ala Phe Phe Asp Asn Arg Ser Ala Ala 3265 3270 3275 gct gcc ggc cta gct cca gaa att gtt ttg tat act gaa aat gtg 19133 Ala Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn Val 3280 3285 3290 gat ttg gaa act cca gat acc cat att gta tac aaa gca ggc aca 19178 Asp Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr 3295 3300 3305 gat gac agc agc tct tct att aat ttg ggc cag caa gcc atg ccc 19223 Asp Asp Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ala Met Pro 3310 3315 3320 aac aga cct aac tac att ggc ttc aga gac aac ttt atc ggg ctc 19268 Asn Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu 3325 3330 3335 atg tac tac aac agc act ggc aat atg ggg gtg ctg gcc ggt cag 19313 Met Tyr Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln 3340 3345 3350 gct tct cag ctg aat gct gtg gtt gac ttg caa gac aga aac acc 19358 Ala Ser Gln Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr 3355 3360 3365 gag ctg tcc tac cag ctc ttg ctt gac tct ctg ggc gac aga acc 19403 Glu Leu Ser Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr 3370 3375 3380 cgg tat ttc agt atg tgg aat cag gcg gtg gac agc tat gat cct 19448 Arg Tyr Phe Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro 3385 3390 3395 gat gta cgc att att gaa aat cat ggt gtg gag gat gaa ctt ccc 19493 Asp Val Arg Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro 3400 3405 3410 aac tat tgt ttc cct ctg gat gct gtt ggc aaa aca gat act tat 19538 Asn Tyr Cys Phe Pro Leu Asp Ala Val Gly Lys Thr Asp Thr Tyr 3415 3420 3425 cag gga att aag gct aat gga act gat caa acc aca tgg acc aaa 19583 Gln Gly Ile Lys Ala Asn Gly Thr Asp Gln Thr Thr Trp Thr Lys 3430 3435 3440 gat gac agt gtc aat gat gct aat gag ata ggc aag ggt aat cca 19628 Asp Asp Ser Val Asn Asp Ala Asn Glu Ile Gly Lys Gly Asn Pro 3445 3450 3455 ttt gct atg gag atc aac atc caa gcc aac ctg tgg agg aac ttc 19673 Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg Asn Phe 3460 3465 3470 ctc tac gcc aac gtg gcc ctg tac ctg ccc gat tct tac aag tac 19718 Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr Lys Tyr 3475 3480 3485 acg ccg gcc aac gtc acc ctg ccc gcc aac acc aac acc tac gat 19763 Thr Pro Ala Asn Val Thr Leu Pro Ala Asn Thr Asn Thr Tyr Asp 3490 3495 3500 tac atg aac ggc cgg gtg gtg gcg ccc tcg ctg gtg gac gcc tat 19808 Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp Ala Tyr 3505 3510 3515 atc aac atc ggg gcg cgc tgg tcg ctg gac ccc atg gac aac gtc 19853 Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn Val 3520 3525 3530 aat ccc ttc aac cac cac cgc aac gcg ggg ctg cgc tac cgc tcc 19898 Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser 3535 3540 3545 atg ctc ctg ggc aac ggg cgc tac gtg ccc ttc cac atc cag gtg 19943 Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val 3550 3555 3560 ccc cag aaa ttt ttc gcc atc aag agc ctc ctg ctc ctg ccc ggg 19988 Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly 3565 3570 3575 tcc tac acc tac gag tgg aac ttc cgc aag gac gtc aac atg atc 20033 Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile 3580 3585 3590 ctg cag agc tcc ctc ggc aac gac ctg cgc acg gac ggg gcc tcc 20078 Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser 3595 3600 3605 atc tcc ttc acc agc atc aac ctc tac gcc acc ttc ttc ccc atg 20123 Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met 3610 3615 3620 gcg cac aac acg gcc tcc acg ctc gag gcc atg ctg cgc aac gac 20168 Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp 3625 3630 3635 acc aac gac cag tcc ttc aac gac tac ctc tcg gcg gcc aac atg 20213 Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met 3640 3645 3650 ctc tac ccc atc ccg gcc aac gcc acc aac gtg ccc atc tcc atc 20258 Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile 3655 3660 3665 ccc tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc acg cgt 20303 Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg 3670 3675 3680 ctc aag acc aag gag acg ccc tcg ctg ggc tcc ggg ttc gac ccc 20348 Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro 3685 3690 3695 tac ttc gtc tac tcg ggc tcc atc ccc tac ctc gac ggc acc ttc 20393 Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly Thr Phe 3700 3705 3710 tac ctc aac cac acc ttc aag aag gtc tcc atc acc ttc gac tcc 20438 Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe Asp Ser 3715 3720 3725 tcc gtc agc tgg ccc ggc aac gac cgg ctc ctg acg ccc aac gag 20483 Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro Asn Glu 3730 3735 3740 ttc gaa atc aag cgc acc gtc gac ggc gag gga tac aac gtg gcc 20528 Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn Val Ala 3745 3750 3755 cag tgc aac atg acc aag gac tgg ttc ctg gtc cag atg ctg gcc 20573 Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu Ala 3760 3765 3770 cac tac aac atc ggc tac cag ggc ttc tac gtg ccc gag ggc tac 20618 His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr 3775 3780 3785 aag gac cgc atg tac tcc ttc ttc cgc aac ttc cag ccc atg agc 20663 Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser 3790 3795 3800 cgc cag gtg gtg gac gag gtc aac tac aag gac tac cag gcc gtc 20708 Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val 3805 3810 3815 acc cta gcc tac cag cac aac aac tcg ggc ttc gtc ggc tac ctc 20753 Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu 3820 3825 3830 gcg ccc acc atg cgc cag gga cag ccc tac ccc gcc aac tac ccc 20798 Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro 3835 3840 3845 tac ccg ctc atc ggc aag agc gcc gtc gcc agc gtc acc cag aaa 20843 Tyr Pro Leu Ile Gly Lys Ser Ala Val Ala Ser Val Thr Gln Lys 3850 3855 3860 aag ttc ctc tgc gac cgg gtc atg tgg cgc atc ccc ttc tcc agc 20888 Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser 3865 3870 3875 aac ttc atg tcc atg ggc gcg ctc acc gac ctc ggc cag aac atg 20933 Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met 3880 3885 3890 ctc tac gcc aac tcc gcc cac gcg cta gac atg aat ttc gaa gtc 20978 Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val 3895 3900 3905 gac ccc atg gat gag tcc acc ctt ctc tat gtt gtc ttc gaa gtc 21023 Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val 3910 3915 3920 ttc gac gtc gtc cga gtg cac cag ccc cac cgc ggc gtc atc gag 21068 Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val Ile Glu 3925 3930 3935 gcc gtc tac ctg cgc acg ccc ttc tcg gcc ggc aac gcc acc acc 21113 Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala Thr Thr 3940 3945 3950 taagcctctt gcttcttgca ag atg acg gcc tgt gcg ggc tcc ggc gag 21162 Met Thr Ala Cys Ala Gly Ser Gly Glu 3955 3960 cag gag ctc agg gcc atc ctc cgc gac ctg ggc tgc ggg ccc tgc 21207 Gln Glu Leu Arg Ala Ile Leu Arg Asp Leu Gly Cys Gly Pro Cys 3965 3970 3975 ttc ctg ggc acc ttc gac aag cgc ttc ccg gga ttc atg gcc ccg 21252 Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala Pro 3980 3985 3990 cac aag ctg gcc tgc gcc atc gtc aac acg gcc ggc cgc gag acc 21297 His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu Thr 3995 4000 4005 ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc acc cac 21342 Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg Thr His 4010 4015 4020 acc tgc tac ctc ttc gac ccc ttc ggg ttc tca gac gag cgc ctc 21387 Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg Leu 4025 4030 4035 aag cag atc tac cag ttc gag tac gag ggc ctg ctg cgc cgc agc 21432 Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg Ser 4040 4045 4050 gcc ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag tcc acc 21477 Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser Thr 4055 4060 4065 cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttc tgc 21522 Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe Cys 4070 4075 4080 tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc atg 21567 Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 4085 4090 4095 gac aag aac ccc acc atg aac ttg ctg acg ggg gtg ccc aac ggc 21612 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly 4100 4105 4110 atg ctc cag tcg ccc cag gtg gaa acc acc ctg cgc cgc aac cag 21657 Met Leu Gln Ser Pro Gln Val Glu Thr Thr Leu Arg Arg Asn Gln 4115 4120 4125 gag gcg ctc tac cgc ttc ctc aac gcc cac tcc gcc tac ttt cgc 21702 Glu Ala Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg 4130 4135 4140 tcc cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac cgc atg 21747 Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met 4145 4150 4155 aat caa gac atg taaaaaaccg gtgtgtgtat gtgaatgctt tattaataaa 21799 Asn Gln Asp Met cagcacatgt ttatgccacc ttctctgagg ctctgacttt atttagaaat cgaaggggtt 21859 ctgccggctc tcggcgtgcc ccgcgggcag ggatacgttg cggaactggt acttgggcag 21919 ccacttgaac tcggggatca gcagcttggg cacggggagg tcggggaacg agtcgctcca 21979 cagcttgcgc gtgagttgca gggcgcccag caggtcgggc gcggagatct tgaaatcgca 22039 gttgggaccc gcgttctgcg cgcgagagtt acggtacacg gggttgcagc actggaacac 22099 catcagggcc gggtgcttca cgctcgccag caccgtcgcg tcggtgatgc cctccacgtc 22159 cagatcctcg gcgttggtca tcccgaaggg ggtcatcttg caggtctgcc gccccatgct 22219 gggcacgcag ccgggcttgt ggttgcaatc gcagtgcagg gggatcagca tcatctgggc 22279 ctgctcggag ctcatgcccg ggtacatggc cttcatgaaa gcctccagct ggcggaaggc 22339 ctgctgcgcc ttgccgccct cggtgaagaa gaccccgcag gacttgctag agaactggtt 22399 ggtggcgcag ccggcgtcgt gcacgcagca gcgcgcgtcg ttgttggcca gctgcaccac 22459 gctgcgtccc cagcggttct gggtgatctt ggcccggtcg gggttctcct tcagcgcgcg 22519 ctgcccgttc tcgctcgcca catccatctc gatcgtgtgc tccttctgga tcatcacggt 22579 cccgtgcagg caccgcagct tgccctcggc ctcggtgcag ccgtgcagcc acagcgcgca 22639 gccggtgctc tcccagttct tgtgggcgat ctgggagtgc gagtgcacga agccctgcag 22699 gaagcggccc atcatcgtgg tcagggtctt gttgctggtg aaggtcagcg ggatgccgcg 22759 gtgctcctcg ttcacataca ggtggcagat gcggcggtac acctcgccct gctcgggcat 22819 cagctggaag gcggacttca ggtcgctctc cacgcggtac cggtccatca gcagcgtcat 22879 cacttccatg cccttctccc aggccgagac gatcggcagg ctcagggggt tcttcaccgt 22939 tgtcatctta gtcgccgccg ccgaggtcag ggggtcgttc tcgtccaggg tctcaaacac 22999 tcgcttgccg tccttctcgg tgatgcgcac gggggggaag gcgaagccca cggccgccag 23059 ctcctcctcg gcctgccttt cgtcctcgct gtcctggctg atgtcttgca aaggcacatg 23119 cttggtcttg cggggtttct ttttgggcgg cagaggcggc ggcgatgtgc tgggcgagcg 23179 cgagttctcg ctcaccacga ctatttcttc tccttggccg tcgtccgaga ccacgcggcg 23239 gtaggcatgc ctcttctggg gcagaggcgg aggcgacggg ctctcgcggt tcggcgggcg 23299 gctggcagag ccccttccgc gttcgggggt gcgctcctgg cggcgctgct ctgactgact 23359 tcctccgcgg ccggccattg tgttctccta gggagcaagc atg gag act cag cca 23414 Met Glu Thr Gln Pro 4160 tcg tcg cca aca tcg cca tct gcc ccc gcc gcc gcc gac gag aac 23459 Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala Ala Asp Glu Asn 4165 4170 4175 cag cag cag cag aat gaa agc tta acc gcc ccg ccg ccc agc ccc 23504 Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro Ser Pro 4180 4185 4190 acc tcc gac gcg gcc cca gac atg caa gag atg gag gaa tcc atc 23549 Thr Ser Asp Ala Ala Pro Asp Met Gln Glu Met Glu Glu Ser Ile 4195 4200 4205 gag att gac ctg ggc tac gtg acg ccc gcg gag cac gag gag gag 23594 Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu Glu 4210 4215 4220 ctg gca gcg cgc ttt tca gcc ccg gaa gag aac cac caa gag cag 23639 Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln 4225 4230 4235 cca gag cag gaa gca gag agc gag cag cag cag gct ggg ctc gag 23684 Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly Leu Glu 4240 4245 4250 cat ggc gac tac ctg agc ggg gca gag gac gtg ctc atc aag cat 23729 His Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His 4255 4260 4265 ctg gcc cgc caa tgc atc atc gtc aag gac gcg ctg ctc gac cgc 23774 Leu Ala Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg 4270 4275 4280 gcc gag gtg ccc ctc agc gtg gcg gag ctc agc cgc gcc tac gag 23819 Ala Glu Val Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu 4285 4290 4295 cgc aac ctc ttc tcg ccg cgc gtg ccc ccc aag cgc cag ccc aac 23864 Arg Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn 4300 4305 4310 ggc acc tgc gag ccc aac ccg cgc ctc aac ttc tac ccg gtc ttc 23909 Gly Thr Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe 4315 4320 4325 gcg gtg ccc gag gcc ctg gcc acc tac cac ctc ttt ttc aag aac 23954 Ala Val Pro Glu Ala Leu Ala Thr Tyr His Leu Phe Phe Lys Asn 4330 4335 4340 caa agg atc ccc gtc tcc tgc cgc gcc aac cgc acc cgc gcc gac 23999 Gln Arg Ile Pro Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp 4345 4350 4355 gcc ctg ctc aac ctg ggc ccc ggc gcc cgc cta cct gat atc gcc 24044 Ala Leu Leu Asn Leu Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala 4360 4365 4370 tcc ttg gaa gag gtt ccc aag atc ttc gag ggt ctg ggc agc gac 24089 Ser Leu Glu Glu Val Pro Lys Ile Phe Glu Gly Leu Gly Ser Asp 4375 4380 4385 gag act cgg gcc gcg aac gct ctg caa gga agc gga gag gag cat 24134 Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly Ser Gly Glu Glu His 4390 4395 4400 gag cac cac agc gcc ctg gtg gag ttg gaa ggc gac aac gcg cgc 24179 Glu His His Ser Ala Leu Val Glu Leu Glu Gly Asp Asn Ala Arg 4405 4410 4415 ctg gcg gtc ctc aag cgc acg gtc gag ctg acc cac ttc gcc tac 24224 Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His Phe Ala Tyr 4420 4425 4430 ccg gcg ctc aac ctg ccc ccc aag gtc atg agc gcc gtc atg gac 24269 Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala Val Met Asp 4435 4440 4445 cag gtg ctc atc aag cgc gcc tcg ccc ctc tcg gag gag gag atg 24314 Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu Met 4450 4455 4460 cag gac ccc gag agc tcg gac gag ggc aag ccc gtg gtc agc gac 24359 Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp 4465 4470 4475 gag cag ctg gcg cgc tgg ctg gga gcg agt agc acc ccc cag agc 24404 Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln Ser 4480 4485 4490 ctg gaa gag cgg cgc aag ctc atg atg gcc gtg gtc ctg gtg acc 24449 Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr 4495 4500 4505 gtg gag ctg gag tgt ctg cgc cgc ttc ttc gcc gac gcg gag acc 24494 Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr 4510 4515 4520 ctg cgc aag gtc gag gaa aac ctg cac tac ctc ttc agg cac ggg 24539 Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly 4525 4530 4535 ttc gtg cgc cag gcc tgc aag atc tcc aac gtg gag ctg acc aac 24584 Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn 4540 4545 4550 ctg gtc tcc tac atg ggc atc ctg cac gag aac cgc ctg ggg cag 24629 Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn Arg Leu Gly Gln 4555 4560 4565 aac gtg ctg cac acc acc ctg cgc ggg gag gcc cgc cgc gac tac 24674 Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala Arg Arg Asp Tyr 4570 4575 4580 atc cgc gac tgc gtc tac ctg tac ctc tgc cac acc tgg cag acg 24719 Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His Thr Trp Gln Thr 4585 4590 4595 ggc atg ggc gtg tgg cag cag tgc ctg gag gag cag aac ctg aaa 24764 Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu Gln Asn Leu Lys 4600 4605 4610 gag ctc tgc aag ctc ctg cag aag aac ctc aag gcc ctg tgg acc 24809 Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys Ala Leu Trp Thr 4615 4620 4625 ggg ttc gac gag cgc acc acc gcc tcg gac ctg gcc gac ctc atc 24854 Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu Ala Asp Leu Ile 4630 4635 4640 ttc ccc gag cgc ctg cgg ctg acg ctg cgc aac ggt ctg ccc gac 24899 Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn Gly Leu Pro Asp 4645 4650 4655 ttt atg agc caa agc atg ttg caa aac ttt cgc tct ttc atc ctc 24944 Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser Phe Ile Leu 4660 4665 4670 gaa cgc tcc ggg atc ctg ccc gcc acc tgc tcc gcg ctg ccc tcg 24989 Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu Pro Ser 4675 4680 4685 gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc ccg ccg ctc tgg 25034 Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu Trp 4690 4695 4700 agc cac tgc tac ttg ctg cgc ctg gcc aac tac ctg gcc tac cac 25079 Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His 4705 4710 4715 tcg gac gtg atc gag gac gtc agc ggc gag ggt ctg ctc gag tgc 25124 Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys 4720 4725 4730 cac tgc cgc tgc aac ctc tgc acg ccg cac cgc tcc ctg gcc tgc 25169 His Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys 4735 4740 4745 aac ccc cag ctg ctg agc gag acc cag atc atc ggc acc ttc gag 25214 Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu 4750 4755 4760 ttg caa ggc ccc ggc gag ggc aag ggg ggt ctg aaa ctc acc ccg 25259 Leu Gln Gly Pro Gly Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro 4765 4770 4775 ggg ctg tgg acc tcg gcc tac ttg cgc aag ttc gtg ccc gag gac 25304 Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 4780 4785 4790 tac cat ccc ttc gag atc agg ttc tac gag gac caa tcc cag ccg 25349 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro 4795 4800 4805 ccc aag gcc gag ctg tcg gcc tgc gtc atc acc cag ggg gcc atc 25394 Pro Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile 4810 4815 4820 ctg gcc caa ttg caa gcc atc cag aaa tcc cgc caa gaa ttt ctg 25439 Leu Ala Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu 4825 4830 4835 ctg aaa aag ggc cac ggg gtc tac ctg gac ccc cag acc gga gag 25484 Leu Lys Lys Gly His Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu 4840 4845 4850 gag ctc aac ccc agc ttc ccc cag gat gcc ccg agg aag cag caa 25529 Glu Leu Asn Pro Ser Phe Pro Gln Asp Ala Pro Arg Lys Gln Gln 4855 4860 4865 gaa gct gaa agt gga gct gcc gct gcc gcc gga gga ttt gga gga 25574 Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala Gly Gly Phe Gly Gly 4870 4875 4880 aga ctg gga gag cag tca ggc aga gga gat gga aga ctg gga cag 25619 Arg Leu Gly Glu Gln Ser Gly Arg Gly Asp Gly Arg Leu Gly Gln 4885 4890 4895 cac tca ggc aga gga gga cag cct gca aga cag tct gga gga gga 25664 His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser Gly Gly Gly 4900 4905 4910 aga cga ggt gga gga gga ggc aga gga aga agc agc cgc cgc cag 25709 Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg Arg Gln 4915 4920 4925 acc gtc gtc ctc ggc gga gaa agc aag cag cac gga tac cat ctc 25754 Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr His Leu 4930 4935 4940 cgc tcc ggg tcg ggg tcg cgg cgg ccg ggc cca cag tagatgggac 25800 Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 4945 4950 4955 gagaccgggc gcttcccaaa ccccaccacc cagaccggta agaaggagcg gcagggatac 25860 aagtcctggc gggggcacaa aaacgccatc gtctcctgct tgcaagcctg cgggggcaac 25920 atctccttca cccggcgcta cctgctcttc caccgcgggg tgaacttccc ccgcaacatc 25980 ttgcattact accgtcacct ccacagcccc tactactgtt tccaagaaga ggcagaaacc 26040 cagcagcagc agaaaaccag cagcagcagc agcagcagct agaaaatcca cagcggcggc 26100 ggcaggtgga ctgaggatcg cggcgaacga gccggcgcag acccgggagc tgaggaaccg 26160 gatctttccc accctctatg ccatcttcca gcagagtcgg gggcaggagc aggaactgaa 26220 agtcaagaac cgttctctgc gctcgctcac ccgcagttgt ctgtatcaca agagcgaaga 26280 ccaacttcag cgcactctcg aggacgccga ggctctcttc aacaagtact gcgcgctcac 26340 tcttaaagag tagcccgcgc ccgcccacac acggaaaaag gcgggaatta cgtcaccacc 26400 tgcgcccttc gcccgaccat catc atg agc aaa gag att ccc acg cct tac 26451 Met Ser Lys Glu Ile Pro Thr Pro Tyr 4960 4965 atg tgg agc tac cag ccc cag atg ggc ctg gcc gcc ggc gcc gcc 26496 Met Trp Ser Tyr Gln Pro Gln Met Gly Leu Ala Ala Gly Ala Ala 4970 4975 4980 cag gac tac tcc acc cgc atg aac tgg ctc agt gcc ggg ccc gcg 26541 Gln Asp Tyr Ser Thr Arg Met Asn Trp Leu Ser Ala Gly Pro Ala 4985 4990 4995 atg atc tca cgg gtg aat gac atc cgc gcc cac cga aac cag ata 26586 Met Ile Ser Arg Val Asn Asp Ile Arg Ala His Arg Asn Gln Ile 5000 5005 5010 ctc cta gaa cag tca gca atc acc gcc acg ccc cgc cat cac ctt 26631 Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr Pro Arg His His Leu 5015 5020 5025 aat ccg cgt aat tgg ccc gcc gcc ctg gtg tac cag gaa att ccc 26676 Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr Gln Glu Ile Pro 5030 5035 5040 cag ccc acg acc gta cta ctt ccg cga gac gcc cag gcc gaa gtc 26721 Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln Ala Glu Val 5045 5050 5055 cag ctg act aac tca ggt gtc cag ctg gcc ggc ggc gcc gcc ctg 26766 Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala Ala Leu 5060 5065 5070 tgt cgt cac cgc ccc gct cag ggt ata aag cgg ctg gtg atc cga 26811 Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile Arg 5075 5080 5085 ggc aga ggc aca cag ctc aac gac gag gtg gtg agc tct tcg ctg 26856 Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 5090 5095 5100 ggt ctg cga cct gac gga gtc ttc caa ctc gcc gga tcg ggg aga 26901 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg 5105 5110 5115 tct tcc ttc acg cct cgt cag gcc gtc ctg act ttg gag agt tcg 26946 Ser Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser 5120 5125 5130 tcc tcg cag ccc cgc tcg ggt ggc atc ggc act ctc cag ttc gtg 26991 Ser Ser Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val 5135 5140 5145 gag gag ttc act ccc tcg gtc tac ttc aac ccc ttc tcc ggc tcc 27036 Glu Glu Phe Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser 5150 5155 5160 ccc ggc cac tac ccg gac gag ttc atc ccg aac ttc gac gcc atc 27081 Pro Gly His Tyr Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile 5165 5170 5175 agc gag tcg gtg gac ggc tac gat tga atg tcc cat ggt ggc gcg 27126 Ser Glu Ser Val Asp Gly Tyr Asp Met Ser His Gly Gly Ala 5180 5185 gct gac cta gct cgg ctt cga cac ctg gac cac tgc cgc cgc ttc 27171 Ala Asp Leu Ala Arg Leu Arg His Leu Asp His Cys Arg Arg Phe 5190 5195 5200 cgc tgc ttc gct cgg gat ctc gcc gag ttt gcc tac ttt gag ctg 27216 Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala Tyr Phe Glu Leu 5205 5210 5215 ccc gag gag cac cct cag ggc ccg gcc cac gga gtg cgg atc gtc 27261 Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val Arg Ile Val 5220 5225 5230 gtc gaa ggg ggc ctc gac tcc cac ctg ctt cgg atc ttc agc cag 27306 Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe Ser Gln 5235 5240 5245 cga ccg atc ctg gtc gag cgc gag caa gga cag acc ctt ctg acc 27351 Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Leu Leu Thr 5250 5255 5260 ctg tac tgc atc tgc aac cgc ccc ggc ctg cat gaa agt ctt tgt 27396 Leu Tyr Cys Ile Cys Asn Arg Pro Gly Leu His Glu Ser Leu Cys 5265 5270 5275 tgt ctg ctg tgt act gag tat aat aaa agc tgaaatcagc gactactccg 27446 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 5280 5285 gactcgattg tggtgttcct gctatcaacc ggtccctgtt cttcaccggg aacgagaccg 27506 agcttcagct ccagtgtaag ccccacaaga agtacctcac ctggctgttc cagggctctc 27566 cgatcgccgt tgtcaaccac tgcgacaacg acggagtcct gctgagcggc cctgccaacc 27626 ttactttttc cacccgcaga agcaagctcc agctcttcca acccttcctc cccgggacct 27686 atcagtgcgt ctcgggaccc tgccatcaca ccttccacct gatcccgaat accacagcgt 27746 cgctccccgc tactaacaac caatctaccc accaacgcca ccgtcgcgac ctttcctctg 27806 aatctaatac taccacccac accggaggtg agctccgagg tcgaccaacc tctgggattt 27866 actacggccc ctgggaggtg gtggggttaa tagcgctagg cctagttgtg ggtgggcttt 27926 tggctctctg ctacctatac ctcccttgct gttcgtactt agtggtgctg tgttgctggt 27986 ttaagaa atg ggg aag atc acc cta gtg agc tgc ggt gtg ccg gtg 28032 Met Gly Lys Ile Thr Leu Val Ser Cys Gly Val Pro Val 5290 5295 5300 gcg gtg gtg gtg ctt tcg att gtg gga ctg ggc ggc gcg gct gta 28077 Ala Val Val Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val 5305 5310 5315 gtg aag gag gag aag gcc gat tcc tgc ttg cat ttc aat ccc gac 28122 Val Lys Glu Glu Lys Ala Asp Ser Cys Leu His Phe Asn Pro Asp 5320 5325 5330 aaa tgc cag ctg agt ttt cag ccc gat ggc aat cgg tgc acg gtg 28167 Lys Cys Gln Leu Ser Phe Gln Pro Asp Gly Asn Arg Cys Thr Val 5335 5340 5345 ctg atc aag tgc gga tgg gaa tgc gag aac gtg aga atc gag tac 28212 Leu Ile Lys Cys Gly Trp Glu Cys Glu Asn Val Arg Ile Glu Tyr 5350 5355 5360 aat aac aag act cgg aac aat act ctc gcg tcc gtg tgg cag ccc 28257 Asn Asn Lys Thr Arg Asn Asn Thr Leu Ala Ser Val Trp Gln Pro 5365 5370 5375 ggg gac ccc gag tgg tac acc gtc tct gtc ccc ggt gct gac ggc 28302 Gly Asp Pro Glu Trp Tyr Thr Val Ser Val Pro Gly Ala Asp Gly 5380 5385 5390 tcc ccg cgc acc gtg aat aat act ttc att ttt gca cac atg tgc 28347 Ser Pro Arg Thr Val Asn Asn Thr Phe Ile Phe Ala His Met Cys 5395 5400 5405 gac acg gtc atg tgg atg agc aag cag tac gat atg tgg ccc ccc 28392 Asp Thr Val Met Trp Met Ser Lys Gln Tyr Asp Met Trp Pro Pro 5410 5415 5420 acg aag gag aac atc gtg gtc ttc tcc atc gct tac agc ctg tgc 28437 Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser Leu Cys 5425 5430 5435 acg gcg cta atc acc gct atc gtg tgc ctg agc att cac atg ctc 28482 Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met Leu 5440 5445 5450 atc gct att cgc ccc aga aat aat gcc gag aaa gag aaa cag cca 28527 Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5455 5460 5465 taacacgttt ttttacacac ctttttcaga cc atg gcc tct gtt act gcc cta 28580 Met Ala Ser Val Thr Ala Leu 5470 att att ttt ttg ggc ctt gtg ggc act agc agc act ttt gat cat 28625 Ile Ile Phe Leu Gly Leu Val Gly Thr Ser Ser Thr Phe Asp His 5475 5480 5485 aaa aac tta act gtt ttt gtt ggt tct gat gtt aca cta ccc ggg 28670 Lys Asn Leu Thr Val Phe Val Gly Ser Asp Val Thr Leu Pro Gly 5490 5495 5500 cat caa tcg cac cag agg gtt tca tgg tat cat ttt aat aaa cag 28715 His Gln Ser His Gln Arg Val Ser Trp Tyr His Phe Asn Lys Gln 5505 5510 5515 aac aca gct tat aca ctt tgc aaa ggt cat cag caa gcc aca tat 28760 Asn Thr Ala Tyr Thr Leu Cys Lys Gly His Gln Gln Ala Thr Tyr 5520 5525 5530 cgc agt ggt ctt tat tac aga tgc aat aac aat aac ctc aca cta 28805 Arg Ser Gly Leu Tyr Tyr Arg Cys Asn Asn Asn Asn Leu Thr Leu 5535 5540 5545 ctc tca gtt aat gca aat tat tct ggc aca tac tat gga acc aat 28850 Leu Ser Val Asn Ala Asn Tyr Ser Gly Thr Tyr Tyr Gly Thr Asn 5550 5555 5560 ttt aac aca aaa cag gac act tac tat agt gtc aaa gta ttg aat 28895 Phe Asn Thr Lys Gln Asp Thr Tyr Tyr Ser Val Lys Val Leu Asn 5565 5570 5575 cca acc tct cct aga act acc act aag cct acc gct acc acc act 28940 Pro Thr Ser Pro Arg Thr Thr Thr Lys Pro Thr Ala Thr Thr Thr 5580 5585 5590 act act gca aag ccc act aaa cct aaa act acc aag aaa acc act 28985 Thr Thr Ala Lys Pro Thr Lys Pro Lys Thr Thr Lys Lys Thr Thr 5595 5600 5605 gtg aag act aca aca act aga acc acc aca act aca gag acc acc 29030 Val Lys Thr Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr 5610 5615 5620 acc agc aca ctt gct gcc act aca cac aca cac att gag cta acc 29075 Thr Ser Thr Leu Ala Ala Thr Thr His Thr His Ile Glu Leu Thr 5625 5630 5635 tta cag acc act aat gat ttg atc gcc ctg ttg caa aag ggg gat 29120 Leu Gln Thr Thr Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp 5640 5645 5650 aac agc acc act tcc gat gag gaa ata ccc aaa tcc atg att ggc 29165 Asn Ser Thr Thr Ser Asp Glu Glu Ile Pro Lys Ser Met Ile Gly 5655 5660 5665 att att gtt gct gta gtg gtg tgc atg ttg atc atc gcc ttg tgc 29210 Ile Ile Val Ala Val Val Val Cys Met Leu Ile Ile Ala Leu Cys 5670 5675 5680 atg gtg tac tat gcc ttc tgc tac aga aag cac aga ctg aac gac 29255 Met Val Tyr Tyr Ala Phe Cys Tyr Arg Lys His Arg Leu Asn Asp 5685 5690 5695 aag ctg gaa cac tta cta agt gtt gaa ttt taatttttta gaacc atg 29303 Lys Leu Glu His Leu Leu Ser Val Glu Phe Met 5700 5705 5710 aag atc cta ggc ctt tta gtt ttt tct atc att acc tct gct ctt 29348 Lys Ile Leu Gly Leu Leu Val Phe Ser Ile Ile Thr Ser Ala Leu 5715 5720 5725 tgt gaa tcg gtg gat aaa gat gtt act att acc act ggt tct aac 29393 Cys Glu Ser Val Asp Lys Asp Val Thr Ile Thr Thr Gly Ser Asn 5730 5735 5740 tat aca ctg aaa ggg cca ccc tca ggt atg ctt tcg tgg tat tgc 29438 Tyr Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys 5745 5750 5755 tat ttt gga act gac tct gaa caa act gag ctt tgc aat gca atg 29483 Tyr Phe Gly Thr Asp Ser Glu Gln Thr Glu Leu Cys Asn Ala Met 5760 5765 5770 aga ggc caa atg cca acc tca aaa att aaa cat aaa tgc aat ggt 29528 Arg Gly Gln Met Pro Thr Ser Lys Ile Lys His Lys Cys Asn Gly 5775 5780 5785 act gat ttg ata ctc ctc aat gtc acg aaa gca tat gct ggc agt 29573 Thr Asp Leu Ile Leu Leu Asn Val Thr Lys Ala Tyr Ala Gly Ser 5790 5795 5800 tac acc tgc cct gga gat gat gct gac agt atg att ttt tac aaa 29618 Tyr Thr Cys Pro Gly Asp Asp Ala Asp Ser Met Ile Phe Tyr Lys 5805 5810 5815 gta act gtt gtt gat ccc act act cca cca ccc acc acc aca act 29663 Val Thr Val Val Asp Pro Thr Thr Pro Pro Pro Thr Thr Thr Thr 5820 5825 5830 act cat acc aca cac aca gaa caa aca cca gag gca gca gga gag 29708 Thr His Thr Thr His Thr Glu Gln Thr Pro Glu Ala Ala Gly Glu 5835 5840 5845 tta gcc ttg cag gtt cag gaa gat tcc ctt atg gct aat acc cct 29753 Leu Ala Leu Gln Val Gln Glu Asp Ser Leu Met Ala Asn Thr Pro 5850 5855 5860 aca ccc gat cat cgg tgt ccg ggg ttg ctc gtc agc ggc att gtc 29798 Thr Pro Asp His Arg Cys Pro Gly Leu Leu Val Ser Gly Ile Val 5865 5870 5875 ggt gtg ctt tcg gga tta gca gtc ata atc atc tgc atg ttc att 29843 Gly Val Leu Ser Gly Leu Ala Val Ile Ile Ile Cys Met Phe Ile 5880 5885 5890 ttt gct tgc tgc tat aga agg ctt tac cga caa aaa tca gac cca 29888 Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln Lys Ser Asp Pro 5895 5900 5905 ctg ctg aac ctc tat gtt taattttttc cagagcc atg aag gca gtt aga 29938 Leu Leu Asn Leu Tyr Val Met Lys Ala Val Arg 5910 5915 gtt cta gtt ttt tgt tct ttg att ggc att gtt ttt agt gct ggg 29983 Val Leu Val Phe Cys Ser Leu Ile Gly Ile Val Phe Ser Ala Gly 5920 5925 5930 ttt ttg aaa aat ctt acc att tat gaa ggt gag aat gcc act cta 30028 Phe Leu Lys Asn Leu Thr Ile Tyr Glu Gly Glu Asn Ala Thr Leu 5935 5940 5945 gtg ggc atc agt ggt caa aat gtc agc tgg cta aaa tac cat cta 30073 Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr His Leu 5950 5955 5960 gat agg tgg aaa gac att tgc gat tgg aat gtc act gtg tat aca 30118 Asp Arg Trp Lys Asp Ile Cys Asp Trp Asn Val Thr Val Tyr Thr 5965 5970 5975 tgt aat gga gtt aac ctc acc att act aat gcc acc caa gat caa 30163 Cys Asn Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 5980 5985 5990 aat ggt agg ttt aag ggt cag agt ttc act aga aat aat ggg tat 30208 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Arg Asn Asn Gly Tyr 5995 6000 6005 gaa tcc cat aac atg ttt atc tat gac gtc act gtc atc aga aat 30253 Glu Ser His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Arg Asn 6010 6015 6020 gag act gcc acc acc acc aca cag atg caa acc aca cag acg acc 30298 Glu Thr Ala Thr Thr Thr Thr Gln Met Gln Thr Thr Gln Thr Thr 6025 6030 6035 aca tac agt aca tca aat cag cct acc acc act aca gca gca gag 30343 Thr Tyr Ser Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu 6040 6045 6050 gtt gcc agc tcg tct ggt gtc aaa gtg gca ttt ttg ttg ttg ccc 30388 Val Ala Ser Ser Ser Gly Val Lys Val Ala Phe Leu Leu Leu Pro 6055 6060 6065 cca tct agc agt ccc act gct agt acc aat gag cag act act gaa 30433 Pro Ser Ser Ser Pro Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu 6070 6075 6080 ttt ttg tcc act gtc gag agc cac acc aca gct acc tcg agt gcc 30478 Phe Leu Ser Thr Val Glu Ser His Thr Thr Ala Thr Ser Ser Ala 6085 6090 6095 ttc tct agc acc gcc aat ctc tcc tcg ctt tcc tct aca cca atc 30523 Phe Ser Ser Thr Ala Asn Leu Ser Ser Leu Ser Ser Thr Pro Ile 6100 6105 6110 agt tcc gct act act act cct agc ccc gct cct ctt ccc act ccc 30568 Ser Ser Ala Thr Thr Thr Pro Ser Pro Ala Pro Leu Pro Thr Pro 6115 6120 6125 ctg aag caa act gag gac agc ggc atg caa tgg cag atc acc ctg 30613 Leu Lys Gln Thr Glu Asp Ser Gly Met Gln Trp Gln Ile Thr Leu 6130 6135 6140 ctc att gtg atc ggg ttg gtc atc ctg gcc gtg ttg ctc tac tac 30658 Leu Ile Val Ile Gly Leu Val Ile Leu Ala Val Leu Leu Tyr Tyr 6145 6150 6155 atc ttc tgc cgc cgc att ccc aac gcg cac cgc aag ccg gtc tac 30703 Ile Phe Cys Arg Arg Ile Pro Asn Ala His Arg Lys Pro Val Tyr 6160 6165 6170 aag ccc atc att gtc ggg cag cca gag ccg ctt cag gtg gaa ggg 30748 Lys Pro Ile Ile Val Gly Gln Pro Glu Pro Leu Gln Val Glu Gly 6175 6180 6185 ggt cta agg aat ctt ctc ttc tct ttt aca gta tgg tgattgaact atg 30797 Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp Met 6190 6195 att cct aga caa ttc ttg atc act att ctt atc tgc ctc ctc caa 30842 Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 6200 6205 6210 gtc tgt gcc acc ctc gct ctg gtg gcc aac gcc agt cca gac tgt 30887 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys 6215 6220 6225 att ggg ccc ttc gcc tcc tac gtg ctc ttt gcc ttc atc acc tgc 30932 Ile Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys 6230 6235 6240 atc tgc tgc tgt agc ata gtc tgc ctg ctt atc acc ttc ttc cag 30977 Ile Cys Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln 6245 6250 6255 ttc att gac tgg atc ttt gtg cgc atc gcc tac ctg cgc cac cac 31022 Phe Ile Asp Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His 6260 6265 6270 ccc cag tac cgc gac cag cga gtg gcg cga ctg ctc agg ctc ctc 31067 Pro Gln Tyr Arg Asp Gln Arg Val Ala Arg Leu Leu Arg Leu Leu 6275 6280 6285 tgataagc atg cgg gct ctg cta ctt ctc gcg ctt ctg ctg tta gtg 31114 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val 6290 6295 6300 ctc ccc cgt ccc gtc gac ccc cgg tcc ccc act cag tcc ccc gag 31159 Leu Pro Arg Pro Val Asp Pro Arg Ser Pro Thr Gln Ser Pro Glu 6305 6310 6315 gag gtc cgc aaa tgc aaa ttc caa gaa ccc tgg aaa ttc ctc aaa 31204 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys 6320 6325 6330 tgc tac cgc caa aaa tca gac atg cat ccc agc tgg atc atg atc 31249 Cys Tyr Arg Gln Lys Ser Asp Met His Pro Ser Trp Ile Met Ile 6335 6340 6345 att ggg atc gtg aac att ctg gcc tgc acc ctc atc tcc ttt gtg 31294 Ile Gly Ile Val Asn Ile Leu Ala Cys Thr Leu Ile Ser Phe Val 6350 6355 6360 att tac ccc tgc ttt gac ttt ggt tgg aac tcg cca gag gcg ctc 31339 Ile Tyr Pro Cys Phe Asp Phe Gly Trp Asn Ser Pro Glu Ala Leu 6365 6370 6375 tat ctc ccg cct gaa cct gac aca cca cca cag cag caa cct cag 31384 Tyr Leu Pro Pro Glu Pro Asp Thr Pro Pro Gln Gln Gln Pro Gln 6380 6385 6390 gca cac gca cta cca cca cca cag cct agg cca caa tac atg ccc 31429 Ala His Ala Leu Pro Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro 6395 6400 6405 ata tta gac tat gag gcc gag cca cag cga ccc atg ctc ccc gct 31474 Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg Pro Met Leu Pro Ala 6410 6415 6420 att agt tac ttc aat cta acc ggc gga gat gac tgacccactg 31517 Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 6425 6430 gccaacaaca acgtcaacga ccttctcctg gacatggacg gccgcgcctc ggagcagcga 31577 ctcgcccaac ttcgcattcg ccagcagcag gagagagccg tcaaggagct gcaggacggc 31637 atagccatcc accagtgcaa gaaaggcatc ttctgcctgg tgaaacaggc caagatctcc 31697 tacgaggtca cccagaccga ccatcgcctc tcctacgagc tcctgcagca gcgccagaag 31757 ttcacctgcc tggtcggagt caaccccatc gtcatcaccc agcagtcggg cgataccaag 31817 gggtgcatcc actgctcctg cgactccccc gactgcgtcc acactctgat caagaccctc 31877 tgcggcctcc gcgacctcct ccccatgaac taatcacccc cttatccagt gaaataaaga 31937 tcatattgat gatgatttaa ataaaaaata atcatttgat ttgaaaataa agatacaatc 31997 atattgatga tttgagttta acaaaaataa agaatcactt acttgaaatc tgataccagg 32057 tctctgtcca tgttttctgc caacaccacc tcactcccct cttcccagct ctggtactgc 32117 aggccccggc gggctgcaaa cttcctccac acgctgaagg ggatgtcaaa ttcctcctgt 32177 ccctcaatct tcattttatc ttctatcag atg tcc aaa aag cgc gtc cgg gtg 32230 Met Ser Lys Lys Arg Val Arg Val 6435 6440 gat gat gac ttc gac ccc gtc tac ccc tac gat gca gac aac gca 32275 Asp Asp Asp Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala 6445 6450 6455 ccg acc gtg ccc ttc atc aac ccc ccc ttc gtc tct tca gat gga 32320 Pro Thr Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly 6460 6465 6470 ttc caa gag aag ccc ctg ggg gtg ctg tcc ctg cgc ctg gcc gac 32365 Phe Gln Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp 6475 6480 6485 ccc gtc acc acc aag aac ggg gct gtc acc ctc aag ctg ggg gag 32410 Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu Lys Leu Gly Glu 6490 6495 6500 ggg gtg gac ctc gac gac tcg gga aaa ctc atc tcc aaa aat gcc 32455 Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser Lys Asn Ala 6505 6510 6515 acc aag gcc act gcc cct ctc agt att tcc aac agc acc att tcc 32500 Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Ser Thr Ile Ser 6520 6525 6530 ctt aac atg gct gcc cct ttt tac aac aac aat gga acg tta agt 32545 Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu Ser 6535 6540 6545 ctc aat gtt tct aca cca tta gca gta ttt ccc act ttt aac act 32590 Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr 6550 6555 6560 tta ggt atc agt ctt ggc aac ggt ctt caa act tct aat aag ttg 32635 Leu Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu 6565 6570 6575 ctg act gta cag tta act cat cct ctt aca ttc agc tca aat agc 32680 Leu Thr Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser 6580 6585 6590 atc aca gta aaa aca gac aaa gga ctc tat att aat tct agt gga 32725 Ile Thr Val Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly 6595 6600 6605 aac aga ggg ctt gag gct aac ata agc cta aaa aga gga ctg att 32770 Asn Arg Gly Leu Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile 6610 6615 6620 ttt gat ggt aat gct att gca aca tac ctt gga agt ggt tta gac 32815 Phe Asp Gly Asn Ala Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp 6625 6630 6635 tat gga tcc tat gat agc gat gga aaa aca aga ccc atc atc acc 32860 Tyr Gly Ser Tyr Asp Ser Asp Gly Lys Thr Arg Pro Ile Ile Thr 6640 6645 6650 aaa att gga gca ggt ttg aat ttt gat gct aat aaa gcc atg gct 32905 Lys Ile Gly Ala Gly Leu Asn Phe Asp Ala Asn Lys Ala Met Ala 6655 6660 6665 gtg aag cta ggc aca ggt tta agt ttt gac tct gcc ggt gcc tta 32950 Val Lys Leu Gly Thr Gly Leu Ser Phe Asp Ser Ala Gly Ala Leu 6670 6675 6680 aca gct gga aac aaa gag gat gac aag cta aca ctt tgg act aca 32995 Thr Ala Gly Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr 6685 6690 6695 cct gac ccc agc cct aat tgt caa tta ctt tca gac aga gat gcc 33040 Pro Asp Pro Ser Pro Asn Cys Gln Leu Leu Ser Asp Arg Asp Ala 6700 6705 6710 aaa ttt acc cta tgt ctt aca aaa tgc ggt agt caa ata cta ggc 33085 Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu Gly 6715 6720 6725 act gtt gca gta gct gct gtt act gta ggt tca gca cta aat cca 33130 Thr Val Ala Val Ala Ala Val Thr Val Gly Ser Ala Leu Asn Pro 6730 6735 6740 att aat gac aca gta aaa agc gcc ata gta ttc ctt aga ttt gat 33175 Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu Arg Phe Asp 6745 6750 6755 tcc aat ggt gtg ctc atg tca aac tca tca atg gta ggc gat tac 33220 Ser Asn Gly Val Leu Met Ser Asn Ser Ser Met Val Gly Asp Tyr 6760 6765 6770 tgg aac ttt agg gaa gga cag acc acc caa agt gtg gcc tat aca 33265 Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr Thr 6775 6780 6785 aat gct gtg gga ttt atg ccc aat cta ggt gca tat cct aaa acc 33310 Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr 6790 6795 6800 caa agc aaa aca cca aaa aat agt ata gtt agt cag gta tat tta 33355 Gln Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu 6805 6810 6815 aat gga gaa acc act atg cca atg aca cta aca ata act ttc aat 33400 Asn Gly Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn 6820 6825 6830 ggc act gat gaa aaa gat aca aca cct gtc agc act tac tct atg 33445 Gly Thr Asp Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met 6835 6840 6845 act ttt aca tgg cag tgg act gga gac tat aag gac aag aat att 33490 Thr Phe Thr Trp Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile 6850 6855 6860 acc ttt gct acc aac tca ttc tct ttc tcc tac atg gcc caa gaa 33535 Thr Phe Ala Thr Asn Ser Phe Ser Phe Ser Tyr Met Ala Gln Glu 6865 6870 6875 taaaccctgc atgccaaccc catccccacc gctctatgga aaactctgaa gcagaaaaat 33595 aaagttcaag tgtttttatt gattcaacag ttttcacagg attcgagtag ttattttccc 33655 tcctccctcc caactcatgg aatacaccac cctctcccca cgcacagcct taaacatctg 33715 aatgccattg gtaatggaca tggttttggt ctccacgttc cacacagttt cagagcgagc 33775 cagtctcggg tcggtcaggg agatgaaacc ctccgggcac tcccgcatct gcacctcaca 33835 gctcaacagc tgaggattgt cctcggtggt cgggatcacg gttatctgga agaagcagaa 33895 gagcggcggt gggaatcata gtccgcgaac gggatcggtc ggtggtgccg catcaggccc 33955 cgcagcagtc gctgccgccg ccgctccgtc aagctgctgc tcagggggtc cgggtccagt 34015 gactccctca gcatgatgcc cacggccctc agcatcagtc gtctggtgcg gcgggcgcag 34075 cagcgcatgc ggatctcgct caggtcactg cagtacgtgc aacacaggac caccaggttg 34135 ttcaacagtc catagttcaa cacgctccag ccgaaactca tcgcgggaag gatgctaccc 34195 acgtggccgt cgtaccagat cctcaggtaa atcaagtggc gctccctcca gaagacgctg 34255 cccatgtaca tgatctcctt gggcatgtgg cggttcacca cctcccggta ccacatcacc 34315 ctctggttga acatgcagcc ccggatgatc ctgcggaacc acagggccag caccgccccg 34375 cccgccatgc agcgaagaga ccccggatcc cggcaatgac aatggaggac ccaccgctcg 34435 tacccgtgga tcatctggga gctgaacaag tctatgttgg cacagcacag gcacacgctc 34495 atgcatctct tcagcactct cagctcctcg ggggtcaaaa ccatatccca gggcacgggg 34555 aactcttgca ggacagcgaa ccccgcagaa cagggcaatc ctcgcacata acttacattg 34615 tgcatggaca gggtatcgca atcaggcagc accgggtgat cctccaccag agaagcgcgg 34675 gtctcggtct cctcacagcg tggtaagggg gccggccgat acgggtgatg gcgggacgcg 34735 gctgatcgtg ttctcgaccg tgtcatgatg cagttgcttt cggacatttt cgtacttgct 34795 gtagcagaac ctggtccggg cgctgcacac cgatcgccgg cggcggtctc ggcgcttgga 34855 acgctcggtg ttaaagttgt aaaacagcca ctctctcaga ccgtgcagca gatctagggc 34915 ctcaggagtg atgaagatcc catcatgcct gatagctctg atcacatcga ccaccgtgga 34975 atgggccagg cccagccaga tgatgcaatt ttgttgggtt tcggtgacgg cgggggaggg 35035 aagaacagga agaaccatga ttaactttta atccaaacgg tctcggagca cttcaaaatg 35095 aaggtcacgg agatggcacc tctcgccccc gctgtgttgg tggaaaataa cagccaggtc 35155 aaaggtgata cggttctcga gatgttccac ggtggcttcc agcaaagcct ccacgcgcac 35215 atccagaaac aagacaatag cgaaagcggg agggttctct aattcctcaa tcatcatgtt 35275 acactcctgc accatcccca gataattttc atttttccag ccttgaatga ttcgaactag 35335 ttcctgaggt aaatccaagc cagccatgat aaagagctcg cgcagagcgc cctccaccgg 35395 cattcttaag cacaccctca taattccaag atattctgct cctggttcac ctgcagcaga 35455 ttgacaagcg gaatatcaaa atctctgccg cgatccctaa gctcctccct cagcaataac 35515 tgtaagtact ctttcatatc ctctccgaaa tttttagcca taggaccgcc aggaatgaga 35575 ttaggacaag ccacattaca gataaaccga agtccccccc agtgagcatt gccaaatgta 35635 agattgaaat aagcatgctg gctagacccg gtgatatctt ccagataact ggacagaaaa 35695 tcgcccaggc aatttttaag aaaatcaaca aaagaaaaat cttccaggtg cacgtttagg 35755 gcctcgggaa caacgatgga gtaagtgcaa ggggtgcgtt ccagcatggt tagttagctg 35815 atctgtaaaa aaacaaaaaa taaaacatta aaccatgcta gcctggcgaa caggtgggta 35875 aatcgttctc tccagcacca ggcaggccac ggggtctccg gcgcgaccct cgtaaaaatt 35935 gtcgctatga ttgaaaacca tcacagagag acgttcccgg tggccggcgt gaatgattcg 35995 acaagatgaa tacacccccg gaacattggc gtccgcgagt gaaaaaaagc gcccaaggaa 36055 gcaataaggc actacaatgc tcagtctcaa gtccagcaaa gcgatgccat gcggatgaag 36115 cacaaaattc tcaggtgcgt acaaaatgta attactcccc tcctgcacag gcagcaaagc 36175 ccccgatccc tccaggtaca catacaaagc ctcagcgtcc atagcttacc gagcagcagc 36235 acacaacagg cgcaagagtc agagaaaggc tgagctctaa cctgtccacc cgctctctgc 36295 tcaatatata gcccagatct acactgacgt aaaggccaaa gtctaaaaat acccgccaaa 36355 tagtcacaca cgcccagcac acgcccagaa accggtgaca cactcagaaa aatacgcgca 36415 cttcctcaaa cgcccaaact gtcgtcattt ccgggttccc acgctacgtc atcagaattc 36475 gactttcaaa ttccgtcgac cgttaaacac gtcacccgcc ccgcccctaa cggtcgcctt 36535 cgtcacagcc aatcagcgcc ccgcatcccc aaattcaaac gcctcatttg catattaacg 36595 cgcaccaaaa gtttgaggta tattattgat gatg 36629 <210> 131 <211> 504 <212> PRT <213> Simian adenovirus 25.2 <400> 131 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ser Gly Leu Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Ser Thr Ala Gly Arg His Ala Glu Asp Pro Glu 35 40 45 Ser Pro Val Thr Pro Gly Thr Pro Thr Pro Pro Ala Ala Ala Ala Gly 50 55 60 Ala Ala Ala Arg Gly Gly Gly Gly Pro Arg Arg Glu Pro Glu Ser Arg 65 70 75 80 Ser Gly Pro Ser Gly Gly Gly Gly Gly Gly Val Ala Asp Leu Phe Pro 85 90 95 Glu Leu Arg Arg Val Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly 100 105 110 Ile Lys Arg Glu Arg His Glu Glu Thr Ser His Arg Thr Glu Leu Thr 115 120 125 Val Ser Leu Met Ser Arg Arg Arg Pro Glu Ser Val Trp Trp His Glu 130 135 140 Val Gln Ser Gln Gly Ile Asp Glu Val Ser Val Met His Glu Lys Tyr 145 150 155 160 Ser Leu Glu Gln Val Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp 165 170 175 Glu Leu Ala Ile Arg Asn Tyr Ala Lys Leu Ala Leu Lys Pro Asp Lys 180 185 190 Lys Tyr Lys Ile Thr Lys Leu Ile Asn Ile Arg Asn Ser Cys Tyr Ile 195 200 205 Ser Gly Asn Gly Ala Glu Val Glu Ile Ser Thr Gln Glu Arg Val Ala 210 215 220 Phe Arg Cys Cys Met Met Asn Met Tyr Pro Gly Val Val Gly Met Glu 225 230 235 240 Gly Val Thr Phe Met Asn Ala Arg Phe Arg Gly Asp Gly Tyr Asn Gly 245 250 255 Val Val Phe Met Ala Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe 260 265 270 Phe Gly Phe Asn Asn Met Cys Ile Glu Ala Trp Gly Ser Val Ser Val 275 280 285 Arg Gly Cys Ser Phe Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr 290 295 300 Lys Ser Lys Val Ser Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu 305 310 315 320 Gly Val Met Ser Glu Gly Glu Ala Lys Val Lys His Cys Ala Ser Thr 325 330 335 Glu Thr Gly Cys Phe Val Leu Ile Lys Gly Asn Ala Gln Val Lys His 340 345 350 Asn Met Ile Cys Gly Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr 355 360 365 Cys Ala Gly Gly Asn Ser His Met Leu Ala Thr Val His Val Ala Ser 370 375 380 His Pro Arg Lys Thr Trp Pro Glu Phe Glu His Asn Val Met Thr Arg 385 390 395 400 Cys Asn Val His Leu Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln 405 410 415 Cys Asn Met Gln Phe Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser 420 425 430 Arg Val Ser Leu Thr Gly Val Phe Asp Met Asn Val Glu Leu Trp Lys 435 440 445 Ile Leu Arg Tyr Asp Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys 450 455 460 Gly Gly Lys His Ala Arg Leu Gln Pro Val Cys Val Glu Val Thr Glu 465 470 475 480 Asp Leu Arg Pro Asp His Leu Val Leu Ser Cys Asn Gly Thr Glu Phe 485 490 495 Gly Ser Ser Gly Glu Glu Ser Asp 500 <210> 132 <211> 142 <212> PRT <213> Simian adenovirus 25.2 <400> 132 Met Ser Gly Ser Ala Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu 1 5 10 15 Thr Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly 20 25 30 Ser Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu 35 40 45 Thr Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala 50 55 60 Ala Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Leu Gly Ala 65 70 75 80 Gly Tyr Tyr Ser Ser Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro 85 90 95 Ala Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu 100 105 110 Ala Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu 115 120 125 Gln Ala Glu Thr Arg Ala Ala Val Ala Thr Val Lys Thr Lys 130 135 140 <210> 133 <211> 395 <212> PRT <213> Simian adenovirus 25.2 <400> 133 Met His Pro Val Leu Arg Gln Met Arg Pro His His Pro Pro Pro Gln 1 5 10 15 Gln Gln Pro Pro Pro Pro Gln Pro Ala Leu Leu Pro Pro Pro Gln Gln 20 25 30 Gln Gln Gln Leu Pro Ala Thr Thr Ala Ala Ala Ala Val Ser Gly Ala 35 40 45 Gly Gln Thr Ser Gln Tyr Asp His Leu Ala Leu Glu Glu Gly Glu Gly 50 55 60 Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu Arg His Pro Arg Val Gln 65 70 75 80 Met Lys Arg Asp Ala Arg Glu Ala Tyr Val Pro Lys Gln Asn Leu Phe 85 90 95 Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu Met Arg Ala Ala Arg Phe 100 105 110 His Ala Gly Arg Glu Leu Arg Arg Gly Leu Asp Arg Lys Arg Val Leu 115 120 125 Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu Thr Gly Ile Ser Pro Ala 130 135 140 Arg Ala His Val Ala Ala Ala Asn Leu Val Thr Ala Tyr Glu Gln Thr 145 150 155 160 Val Lys Glu Glu Ser Asn Phe Gln Lys Ser Phe Asn Asn His Val Arg 165 170 175 Thr Leu Ile Ala Arg Glu Glu Val Thr Leu Gly Leu Met His Leu Trp 180 185 190 Asp Leu Leu Glu Ala Ile Val Gln Asn Pro Thr Ser Lys Pro Leu Thr 195 200 205 Ala Gln Leu Phe Leu Val Val Gln His Ser Arg Asp Asn Glu Ala Phe 210 215 220 Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro Glu Gly Arg Trp Leu Leu 225 230 235 240 Asp Leu Val Asn Ile Leu Gln Ser Ile Val Val Gln Glu Arg Gly Leu 245 250 255 Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn Phe Ser Val Leu Ser Leu 260 265 270 Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys Thr Pro Tyr Val Pro Ile 275 280 285 Asp Lys Glu Val Lys Ile Asp Gly Phe Tyr Met Arg Met Thr Leu Lys 290 295 300 Val Leu Thr Leu Ser Asp Asp Leu Gly Val Tyr Arg Asn Asp Arg Met 305 310 315 320 His Arg Ala Val Ser Ala Ser Arg Arg Arg Glu Leu Ser Asp Gln Glu 325 330 335 Leu Met His Ser Leu Gln Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly 340 345 350 Glu Ser Tyr Phe Asp Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg 355 360 365 Arg Ala Leu Glu Ala Ala Ala Gly Pro Tyr Val Glu Glu Val Asp Asp 370 375 380 Glu Val Asp Glu Glu Gly Glu Tyr Leu Glu Asp 385 390 395 <210> 134 <211> 583 <212> PRT <213> Simian adenovirus 25.2 <400> 134 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asp Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Glu Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Thr Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Arg Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Ala Thr Thr Val Trp Lys Lys 420 425 430 Glu Gly Gly Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Ala Gly 435 440 445 Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro 450 455 460 Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr Arg 465 470 475 480 Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu Leu Arg 485 490 495 Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu Ser Leu Val 500 505 510 Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala His Glu His Arg Asp Glu 515 520 525 Pro Arg Ala Ser Ser Ala Thr Arg Arg Arg Gln Arg His Asp Arg Gln 530 535 540 Arg Gly Leu Val Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val 545 550 555 560 Leu Asp Leu Gly Gly Ser Gly Gly Gly Asn Pro Phe Ala His Leu Arg 565 570 575 Pro Arg Ile Gly Arg Leu Met 580 <210> 135 <211> 531 <212> PRT <213> Simian adenovirus 25.2 <400> 135 Met Met Arg Arg Val Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Val Ala Ala Ala Met Gln Pro Pro Leu Glu Ala 20 25 30 Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 35 40 45 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu Tyr 50 55 60 Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr Gln Asn 65 70 75 80 Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp Phe Thr 85 90 95 Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg Ser Arg 100 105 110 Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro Asn Val 115 120 125 Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met Val Ser 130 135 140 Arg Lys Thr Pro Asn Gly Val Thr Val Gly Asp Asp Tyr Asp Gly Ser 145 150 155 160 Gln Asp Glu Leu Thr Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly 165 170 175 Asn Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile 180 185 190 Asp Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp 195 200 205 Ile Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro 210 215 220 Val Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His 225 230 235 240 Pro Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser 245 250 255 Arg Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu 260 265 270 Gly Phe Gln Ile Leu Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala 275 280 285 Leu Leu Asp Val Asp Ala Tyr Glu Lys Ser Lys Glu Asp Ser Ala Ala 290 295 300 Ala Ala Thr Ala Ala Val Ala Thr Ala Ser Thr Glu Val Arg Gly Asp 305 310 315 320 Asn Phe Ala Ser Ala Ala Ala Val Ala Glu Ala Ala Glu Thr Glu Ser 325 330 335 Lys Ile Val Ile Gln Pro Val Glu Lys Asp Ser Lys Asn Arg Ser Tyr 340 345 350 Asn Val Leu Ala Asp Lys Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu 355 360 365 Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu 370 375 380 Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser 385 390 395 400 Leu Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln 405 410 415 Val Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser 420 425 430 Lys Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala 435 440 445 Phe Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile 450 455 460 Leu Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val 465 470 475 480 Pro Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg 485 490 495 Gly Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro 500 505 510 Tyr Val Tyr Lys Ala Leu Gly Val Val Ala Pro Arg Val Leu Ser Ser 515 520 525 Arg Thr Phe 530 <210> 136 <211> 194 <212> PRT <213> Simian adenovirus 25.2 <400> 136 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ser 130 135 140 Ser Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala 145 150 155 160 Ala Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val 165 170 175 Arg Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro 180 185 190 Arg Thr <210> 137 <211> 348 <212> PRT <213> Simian adenovirus 25.2 <400> 137 Met Ser Lys Arg Lys Tyr Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Leu Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Glu Asp Asp Gly Leu 35 40 45 Val Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg 50 55 60 Gly Arg Lys Val Lys Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe 65 70 75 80 Thr Pro Gly Glu Arg Ser Gly Ser Ala Ser Lys Arg Ser Tyr Asp Glu 85 90 95 Val Tyr Gly Asp Glu Asp Ile Leu Glu Gln Ala Val Glu Arg Leu Gly 100 105 110 Glu Phe Ala Tyr Gly Lys Arg Ser Arg Pro Ala Pro Leu Lys Glu Glu 115 120 125 Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys 130 135 140 Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly 145 150 155 160 Phe Lys Arg Glu Gly Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met 165 170 175 Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu Glu His Met Lys Val 180 185 190 Asp Pro Glu Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val 195 200 205 Ala Pro Gly Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu 210 215 220 Pro Met Glu Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met 225 230 235 240 Glu Val Gln Thr Asp Pro Trp Met Pro Ala Ala Pro Thr Thr Thr Thr 245 250 255 Arg Arg Arg Arg Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr 260 265 270 Ala Leu His Pro Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg 275 280 285 Phe Tyr Arg Gly Tyr Thr Ser Ser Arg Arg Arg Lys Thr Thr Thr Arg 290 295 300 Arg Arg Arg Arg Arg His Thr Arg Arg Ser Ser Thr Ala Thr Ser Ala 305 310 315 320 Ala Ala Leu Val Arg Arg Val Tyr Arg Ser Gly Arg Glu Pro Leu Thr 325 330 335 Leu Pro Arg Ala Arg Tyr His Pro Ser Ile Ala Ile 340 345 <210> 138 <211> 77 <212> PRT <213> Simian adenovirus 25.2 <400> 138 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Thr Gly Asn Gly Leu Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 139 <211> 244 <212> PRT <213> Simian adenovirus 25.2 <400> 139 Met Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg 1 5 10 15 Pro Phe Met Gly Thr Trp Ser Asp Ile Gly Asn Ser Gln Leu Asn Gly 20 25 30 Gly Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly 35 40 45 Ser Thr Leu Lys Thr Tyr Gly Asn Lys Ala Trp Asn Ser Ser Thr Gly 50 55 60 Gln Ala Leu Arg Glu Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val 65 70 75 80 Val Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn 85 90 95 Gln Ala Val Gln Lys Gln Ile Asn Ser Arg Leu Asp Ala Val Pro Pro 100 105 110 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu 115 120 125 Asp Lys Arg Gly Asp Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu 130 135 140 Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu 145 150 155 160 Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu 165 170 175 Lys Pro Glu Ser Asn Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln 180 185 190 Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val 195 200 205 Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln 210 215 220 Ser Thr Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg 225 230 235 240 Arg Arg Cys Tyr <210> 140 <211> 933 <212> PRT <213> Simian adenovirus 25.2 <400> 140 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Cys Gln Trp Thr Tyr Lys Ala Asp Gly Glu Thr Ala 130 135 140 Thr Glu Lys Thr Tyr Thr Tyr Gly Asn Ala Pro Val Gln Gly Ile Asn 145 150 155 160 Ile Thr Lys Asp Gly Ile Gln Leu Gly Thr Asp Thr Asp Asp Gln Pro 165 170 175 Ile Tyr Ala Asp Glu Thr Tyr Gln Pro Glu Pro Gln Val Gly Asp Ala 180 185 190 Glu Trp His Asp Ile Thr Gly Thr Asp Glu Lys Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Pro Asp Thr Lys Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Lys Glu Gly Gly Gln Ala Asn Val Lys Thr Gly Thr Gly 225 230 235 240 Thr Thr Lys Glu Tyr Asp Ile Asp Met Ala Phe Phe Asp Asn Arg Ser 245 250 255 Ala Ala Ala Ala Gly Leu Ala Pro Glu Ile Val Leu Tyr Thr Glu Asn 260 265 270 Val Asp Leu Glu Thr Pro Asp Thr His Ile Val Tyr Lys Ala Gly Thr 275 280 285 Asp Asp Ser Ser Ser Ser Ile Asn Leu Gly Gln Gln Ala Met Pro Asn 290 295 300 Arg Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr 305 310 315 320 Tyr Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln 325 330 335 Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr 340 345 350 Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met 355 360 365 Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu 370 375 380 Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asp 385 390 395 400 Ala Val Gly Lys Thr Asp Thr Tyr Gln Gly Ile Lys Ala Asn Gly Thr 405 410 415 Asp Gln Thr Thr Trp Thr Lys Asp Asp Ser Val Asn Asp Ala Asn Glu 420 425 430 Ile Gly Lys Gly Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn 435 440 445 Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp 450 455 460 Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Ala Asn Thr Asn 465 470 475 480 Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp 485 490 495 Ala Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp Asn 500 505 510 Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr Arg Ser 515 520 525 Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile Gln Val Pro 530 535 540 Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu Pro Gly Ser Tyr 545 550 555 560 Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met Ile Leu Gln Ser 565 570 575 Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser Ile Ser Phe Thr 580 585 590 Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala His Asn Thr Ala 595 600 605 Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn Asp Gln Ser Phe 610 615 620 Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro Ile Pro Ala Asn 625 630 635 640 Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe 645 650 655 Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu 660 665 670 Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr 675 680 685 Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile 690 695 700 Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr 705 710 715 720 Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn 725 730 735 Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met Leu 740 745 750 Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu Gly Tyr 755 760 765 Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro Met Ser Arg 770 775 780 Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln Ala Val Thr Leu 785 790 795 800 Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr Leu Ala Pro Thr 805 810 815 Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro Tyr Pro Leu Ile 820 825 830 Gly Lys Ser Ala Val Ala Ser Val Thr Gln Lys Lys Phe Leu Cys Asp 835 840 845 Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe Met Ser Met Gly 850 855 860 Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala Asn Ser Ala His 865 870 875 880 Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp Glu Ser Thr Leu 885 890 895 Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg Val His Gln Pro 900 905 910 His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala 915 920 925 Gly Asn Ala Thr Thr 930 <210> 141 <211> 208 <212> PRT <213> Simian adenovirus 25.2 <400> 141 Met Thr Ala Cys Ala Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Leu 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Cys Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Thr His Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Thr Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ala His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Gln Asp Met 195 200 205 <210> 142 <211> 797 <212> PRT <213> Simian adenovirus 25.2 <400> 142 Met Glu Thr Gln Pro Ser Ser Pro Thr Ser Pro Ser Ala Pro Ala Ala 1 5 10 15 Ala Asp Glu Asn Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 20 25 30 Pro Ser Pro Thr Ser Asp Ala Ala Pro Asp Met Gln Glu Met Glu Glu 35 40 45 Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu Glu 50 55 60 Glu Leu Ala Ala Arg Phe Ser Ala Pro Glu Glu Asn His Gln Glu Gln 65 70 75 80 Pro Glu Gln Glu Ala Glu Ser Glu Gln Gln Gln Ala Gly Leu Glu His 85 90 95 Gly Asp Tyr Leu Ser Gly Ala Glu Asp Val Leu Ile Lys His Leu Ala 100 105 110 Arg Gln Cys Ile Ile Val Lys Asp Ala Leu Leu Asp Arg Ala Glu Val 115 120 125 Pro Leu Ser Val Ala Glu Leu Ser Arg Ala Tyr Glu Arg Asn Leu Phe 130 135 140 Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro 145 150 155 160 Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu 165 170 175 Ala Thr Tyr His Leu Phe Phe Lys Asn Gln Arg Ile Pro Val Ser Cys 180 185 190 Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Leu Asn Leu Gly Pro Gly 195 200 205 Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile Phe 210 215 220 Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu Gln Gly 225 230 235 240 Ser Gly Glu Glu His Glu His His Ser Ala Leu Val Glu Leu Glu Gly 245 250 255 Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu Thr His 260 265 270 Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser Ala Val 275 280 285 Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Leu Ser Glu Glu Glu 290 295 300 Met Gln Asp Pro Glu Ser Ser Asp Glu Gly Lys Pro Val Val Ser Asp 305 310 315 320 Glu Gln Leu Ala Arg Trp Leu Gly Ala Ser Ser Thr Pro Gln Ser Leu 325 330 335 Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val Glu 340 345 350 Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys 355 360 365 Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln 370 375 380 Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met 385 390 395 400 Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr 405 410 415 Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu 420 425 430 Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys 435 440 445 Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn 450 455 460 Leu Lys Ala Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp 465 470 475 480 Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn 485 490 495 Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser 500 505 510 Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu 515 520 525 Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu 530 535 540 Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His 545 550 555 560 Ser Asp Val Ile Glu Asp Val Ser Gly Glu Gly Leu Leu Glu Cys His 565 570 575 Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro 580 585 590 Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly 595 600 605 Pro Gly Glu Gly Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr 610 615 620 Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu 625 630 635 640 Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser 645 650 655 Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala Ile 660 665 670 Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly His Gly Val Tyr 675 680 685 Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Ser Phe Pro Gln Asp 690 695 700 Ala Pro Arg Lys Gln Gln Glu Ala Glu Ser Gly Ala Ala Ala Ala Ala 705 710 715 720 Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Ser Gly Arg Gly Asp Gly 725 730 735 Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln Pro Ala Arg Gln Ser 740 745 750 Gly Gly Gly Arg Arg Gly Gly Gly Gly Gly Arg Gly Arg Ser Ser Arg 755 760 765 Arg Gln Thr Val Val Leu Gly Gly Glu Ser Lys Gln His Gly Tyr His 770 775 780 Leu Arg Ser Gly Ser Gly Ser Arg Arg Pro Gly Pro Gln 785 790 795 <210> 143 <211> 227 <212> PRT <213> Simian adenovirus 25.2 <400> 143 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Ile Thr Ala Thr 50 55 60 Pro Arg His His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Ala Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 144 <211> 106 <212> PRT <213> Simian adenovirus 25.2 <400> 144 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Ala 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Glu Gln Gly Gln Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asn Arg Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 145 <211> 178 <212> PRT <213> Simian adenovirus 25.2 <400> 145 Met Gly Lys Ile Thr Leu Val Ser Cys Gly Val Pro Val Ala Val Val 1 5 10 15 Val Leu Ser Ile Val Gly Leu Gly Gly Ala Ala Val Val Lys Glu Glu 20 25 30 Lys Ala Asp Ser Cys Leu His Phe Asn Pro Asp Lys Cys Gln Leu Ser 35 40 45 Phe Gln Pro Asp Gly Asn Arg Cys Thr Val Leu Ile Lys Cys Gly Trp 50 55 60 Glu Cys Glu Asn Val Arg Ile Glu Tyr Asn Asn Lys Thr Arg Asn Asn 65 70 75 80 Thr Leu Ala Ser Val Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val 85 90 95 Ser Val Pro Gly Ala Asp Gly Ser Pro Arg Thr Val Asn Asn Thr Phe 100 105 110 Ile Phe Ala His Met Cys Asp Thr Val Met Trp Met Ser Lys Gln Tyr 115 120 125 Asp Met Trp Pro Pro Thr Lys Glu Asn Ile Val Val Phe Ser Ile Ala 130 135 140 Tyr Ser Leu Cys Thr Ala Leu Ile Thr Ala Ile Val Cys Leu Ser Ile 145 150 155 160 His Met Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys 165 170 175 Gln Pro <210> 146 <211> 242 <212> PRT <213> Simian adenovirus 25.2 <400> 146 Met Ala Ser Val Thr Ala Leu Ile Ile Phe Leu Gly Leu Val Gly Thr 1 5 10 15 Ser Ser Thr Phe Asp His Lys Asn Leu Thr Val Phe Val Gly Ser Asp 20 25 30 Val Thr Leu Pro Gly His Gln Ser His Gln Arg Val Ser Trp Tyr His 35 40 45 Phe Asn Lys Gln Asn Thr Ala Tyr Thr Leu Cys Lys Gly His Gln Gln 50 55 60 Ala Thr Tyr Arg Ser Gly Leu Tyr Tyr Arg Cys Asn Asn Asn Asn Leu 65 70 75 80 Thr Leu Leu Ser Val Asn Ala Asn Tyr Ser Gly Thr Tyr Tyr Gly Thr 85 90 95 Asn Phe Asn Thr Lys Gln Asp Thr Tyr Tyr Ser Val Lys Val Leu Asn 100 105 110 Pro Thr Ser Pro Arg Thr Thr Thr Lys Pro Thr Ala Thr Thr Thr Thr 115 120 125 Thr Ala Lys Pro Thr Lys Pro Lys Thr Thr Lys Lys Thr Thr Val Lys 130 135 140 Thr Thr Thr Thr Arg Thr Thr Thr Thr Thr Glu Thr Thr Thr Ser Thr 145 150 155 160 Leu Ala Ala Thr Thr His Thr His Ile Glu Leu Thr Leu Gln Thr Thr 165 170 175 Asn Asp Leu Ile Ala Leu Leu Gln Lys Gly Asp Asn Ser Thr Thr Ser 180 185 190 Asp Glu Glu Ile Pro Lys Ser Met Ile Gly Ile Ile Val Ala Val Val 195 200 205 Val Cys Met Leu Ile Ile Ala Leu Cys Met Val Tyr Tyr Ala Phe Cys 210 215 220 Tyr Arg Lys His Arg Leu Asn Asp Lys Leu Glu His Leu Leu Ser Val 225 230 235 240 Glu Phe <210> 147 <211> 202 <212> PRT <213> Simian adenovirus 25.2 <400> 147 Met Lys Ile Leu Gly Leu Leu Val Phe Ser Ile Ile Thr Ser Ala Leu 1 5 10 15 Cys Glu Ser Val Asp Lys Asp Val Thr Ile Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Pro Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Thr Asp Ser Glu Gln Thr Glu Leu Cys Asn Ala Met Arg Gly Gln 50 55 60 Met Pro Thr Ser Lys Ile Lys His Lys Cys Asn Gly Thr Asp Leu Ile 65 70 75 80 Leu Leu Asn Val Thr Lys Ala Tyr Ala Gly Ser Tyr Thr Cys Pro Gly 85 90 95 Asp Asp Ala Asp Ser Met Ile Phe Tyr Lys Val Thr Val Val Asp Pro 100 105 110 Thr Thr Pro Pro Pro Thr Thr Thr Thr Thr His Thr Thr His Thr Glu 115 120 125 Gln Thr Pro Glu Ala Ala Gly Glu Leu Ala Leu Gln Val Gln Glu Asp 130 135 140 Ser Leu Met Ala Asn Thr Pro Thr Pro Asp His Arg Cys Pro Gly Leu 145 150 155 160 Leu Val Ser Gly Ile Val Gly Val Leu Ser Gly Leu Ala Val Ile Ile 165 170 175 Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu Tyr Arg Gln 180 185 190 Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 <210> 148 <211> 287 <212> PRT <213> Simian adenovirus 25.2 <400> 148 Met Lys Ala Val Arg Val Leu Val Phe Cys Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Tyr Glu Gly Glu Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Arg Trp Lys Asp Ile Cys Asp Trp Asn Val Thr Val Tyr 50 55 60 Thr Cys Asn Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Arg Asn Asn Gly Tyr Glu 85 90 95 Ser His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Arg Asn Glu Thr 100 105 110 Ala Thr Thr Thr Thr Gln Met Gln Thr Thr Gln Thr Thr Thr Tyr Ser 115 120 125 Thr Ser Asn Gln Pro Thr Thr Thr Thr Ala Ala Glu Val Ala Ser Ser 130 135 140 Ser Gly Val Lys Val Ala Phe Leu Leu Leu Pro Pro Ser Ser Ser Pro 145 150 155 160 Thr Ala Ser Thr Asn Glu Gln Thr Thr Glu Phe Leu Ser Thr Val Glu 165 170 175 Ser His Thr Thr Ala Thr Ser Ser Ala Phe Ser Ser Thr Ala Asn Leu 180 185 190 Ser Ser Leu Ser Ser Thr Pro Ile Ser Ser Ala Thr Thr Thr Pro Ser 195 200 205 Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln Thr Glu Asp Ser Gly Met 210 215 220 Gln Trp Gln Ile Thr Leu Leu Ile Val Ile Gly Leu Val Ile Leu Ala 225 230 235 240 Val Leu Leu Tyr Tyr Ile Phe Cys Arg Arg Ile Pro Asn Ala His Arg 245 250 255 Lys Pro Val Tyr Lys Pro Ile Ile Val Gly Gln Pro Glu Pro Leu Gln 260 265 270 Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe Thr Val Trp 275 280 285 <210> 149 <211> 91 <212> PRT <213> Simian adenovirus 25.2 <400> 149 Met Ile Pro Arg Gln Phe Leu Ile Thr Ile Leu Ile Cys Leu Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Pro Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Ile Asp 50 55 60 Trp Ile Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Arg Val Ala Arg Leu Leu Arg Leu Leu 85 90 <210> 150 <211> 144 <212> PRT <213> Simian adenovirus 25.2 <400> 150 Met Arg Ala Leu Leu Leu Leu Ala Leu Leu Leu Leu Val Leu Pro Arg 1 5 10 15 Pro Val Asp Pro Arg Ser Pro Thr Gln Ser Pro Glu Glu Val Arg Lys 20 25 30 Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Lys Cys Tyr Arg Gln Lys 35 40 45 Ser Asp Met His Pro Ser Trp Ile Met Ile Ile Gly Ile Val Asn Ile 50 55 60 Leu Ala Cys Thr Leu Ile Ser Phe Val Ile Tyr Pro Cys Phe Asp Phe 65 70 75 80 Gly Trp Asn Ser Pro Glu Ala Leu Tyr Leu Pro Pro Glu Pro Asp Thr 85 90 95 Pro Pro Gln Gln Gln Pro Gln Ala His Ala Leu Pro Pro Pro Gln Pro 100 105 110 Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala Glu Pro Gln Arg 115 120 125 Pro Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr Gly Gly Asp Asp 130 135 140 <210> 151 <211> 443 <212> PRT <213> Simian adenovirus 25.2 <400> 151 Met Ser Lys Lys Arg Val Arg Val Asp Asp Asp Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu 50 55 60 Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ser 65 70 75 80 Lys Asn Ala Thr Lys Ala Thr Ala Pro Leu Ser Ile Ser Asn Ser Thr 85 90 95 Ile Ser Leu Asn Met Ala Ala Pro Phe Tyr Asn Asn Asn Gly Thr Leu 100 105 110 Ser Leu Asn Val Ser Thr Pro Leu Ala Val Phe Pro Thr Phe Asn Thr 115 120 125 Leu Gly Ile Ser Leu Gly Asn Gly Leu Gln Thr Ser Asn Lys Leu Leu 130 135 140 Thr Val Gln Leu Thr His Pro Leu Thr Phe Ser Ser Asn Ser Ile Thr 145 150 155 160 Val Lys Thr Asp Lys Gly Leu Tyr Ile Asn Ser Ser Gly Asn Arg Gly 165 170 175 Leu Glu Ala Asn Ile Ser Leu Lys Arg Gly Leu Ile Phe Asp Gly Asn 180 185 190 Ala Ile Ala Thr Tyr Leu Gly Ser Gly Leu Asp Tyr Gly Ser Tyr Asp 195 200 205 Ser Asp Gly Lys Thr Arg Pro Ile Ile Thr Lys Ile Gly Ala Gly Leu 210 215 220 Asn Phe Asp Ala Asn Lys Ala Met Ala Val Lys Leu Gly Thr Gly Leu 225 230 235 240 Ser Phe Asp Ser Ala Gly Ala Leu Thr Ala Gly Asn Lys Glu Asp Asp 245 250 255 Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro Asn Cys Gln Leu 260 265 270 Leu Ser Asp Arg Asp Ala Lys Phe Thr Leu Cys Leu Thr Lys Cys Gly 275 280 285 Ser Gln Ile Leu Gly Thr Val Ala Val Ala Ala Val Thr Val Gly Ser 290 295 300 Ala Leu Asn Pro Ile Asn Asp Thr Val Lys Ser Ala Ile Val Phe Leu 305 310 315 320 Arg Phe Asp Ser Asn Gly Val Leu Met Ser Asn Ser Ser Met Val Gly 325 330 335 Asp Tyr Trp Asn Phe Arg Glu Gly Gln Thr Thr Gln Ser Val Ala Tyr 340 345 350 Thr Asn Ala Val Gly Phe Met Pro Asn Leu Gly Ala Tyr Pro Lys Thr 355 360 365 Gln Ser Lys Thr Pro Lys Asn Ser Ile Val Ser Gln Val Tyr Leu Asn 370 375 380 Gly Glu Thr Thr Met Pro Met Thr Leu Thr Ile Thr Phe Asn Gly Thr 385 390 395 400 Asp Glu Lys Asp Thr Thr Pro Val Ser Thr Tyr Ser Met Thr Phe Thr 405 410 415 Trp Gln Trp Thr Gly Asp Tyr Lys Asp Lys Asn Ile Thr Phe Ala Thr 420 425 430 Asn Ser Phe Ser Phe Ser Tyr Met Ala Gln Glu 435 440 <210> 152 <211> 590 <212> DNA <213> Simian adenovirus 25.2 <220> <221> CDS <222> (10)..(585) <223> label=Elb\19K <400> 152 gcaggactc atg gag atc tgg acg gtc ttg gaa gac ttt cat cag act aga 51 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg 1 5 10 cag ctg cta gag aac tca tcg gag gaa gtc tct tac ctg tgg aga ttt 99 Gln Leu Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe 15 20 25 30 tgc ttc ggt ggg gct cta gct aag cta gtc tat agg gcc aaa cag gat 147 Cys Phe Gly Gly Ala Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp 35 40 45 tat aag gat caa ttt gag gat att ttg aga gag tgt cct ggt att ttt 195 Tyr Lys Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe 50 55 60 gac tct ctc aac ttg ggc cat cag tct cac ttt aac cag agt att ctg 243 Asp Ser Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu 65 70 75 aga gcc ctt gac ttt tct act cct ggc aga act acc gcc gcg gta gcc 291 Arg Ala Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala 80 85 90 ttt ttt gcc ttt atc ctt gac aaa tgg agt caa gaa acc cat ttc agc 339 Phe Phe Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser 95 100 105 110 agg gat tac cgt ctg gac tgc tta gca gta gct ttg tgg aga aca tgg 387 Arg Asp Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp 115 120 125 agg tgc cag cgc ctg aat gca atc tcc ggc tac ttg cca gta cag ccg 435 Arg Cys Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro 130 135 140 gta gac acg ctg agg atc ctg agt ctc cag tca ccc cag gaa cac caa 483 Val Asp Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln 145 150 155 cgc cgc cag cag ccg cag cag gag cag cag caa gag gag gag gag gac 531 Arg Arg Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp 160 165 170 cga gaa gag aac ccg aga gcc ggt ctg gac cct ccg gtg gcg gag gag 579 Arg Glu Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu 175 180 185 190 gag gag tagct 590 Glu Glu <210> 153 <211> 192 <212> PRT <213> Simian adenovirus 25.2 <400> 153 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Gln Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ser Ser Glu Glu Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Ala Leu Ala Lys Leu Val Tyr Arg Ala Lys Gln Asp Tyr Lys 35 40 45 Asp Gln Phe Glu Asp Ile Leu Arg Glu Cys Pro Gly Ile Phe Asp Ser 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Ser Ile Leu Arg Ala 65 70 75 80 Leu Asp Phe Ser Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Ile Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Arg Leu Asp Cys Leu Ala Val Ala Leu Trp Arg Thr Trp Arg Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Val Asp 130 135 140 Thr Leu Arg Ile Leu Ser Leu Gln Ser Pro Gln Glu His Gln Arg Arg 145 150 155 160 Gln Gln Pro Gln Gln Glu Gln Gln Gln Glu Glu Glu Glu Asp Arg Glu 165 170 175 Glu Asn Pro Arg Ala Gly Leu Asp Pro Pro Val Ala Glu Glu Glu Glu 180 185 190 <210> 154 <211> 6410 <212> DNA <213> Simian adenovirus 25.2 <220> <221> CDS <222> (10)..(579) <223> label=22K <220> <221> CDS <222> (1883)..(2509) <223> label=E3\CR1\alpha <220> <221> CDS <222> (6003)..(6407) <223> label=E3\14.7K <400> 154 tcccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 51 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ctg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag 99 Leu Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 147 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa 195 Asp Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu 50 55 60 gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca agc agc acg 243 Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 291 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 aga tgg gac gag acc ggg cgc ttc cca aac ccc acc acc cag acc ggt 339 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly 95 100 105 110 aag aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc 387 Lys Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala 115 120 125 atc gtc tcc tgc ttg caa gcc tgc ggg ggc aac atc tcc ttc acc cgg 435 Ile Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg 130 135 140 cgc tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg 483 Arg Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu 145 150 155 cat tac tac cgt cac ctc cac agc ccc tac tac tgt ttc caa gaa gag 531 His Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu 160 165 170 gca gaa acc cag cag cag cag aaa acc agc agc agc agc agc agc agc 579 Ala Glu Thr Gln Gln Gln Gln Lys Thr Ser Ser Ser Ser Ser Ser Ser 175 180 185 190 tagaaaatcc acagcggcgg cggcaggtgg actgaggatc gcggcgaacg agccggcgca 639 gacccgggag ctgaggaacc ggatctttcc caccctctat gccatcttcc agcagagtcg 699 ggggcaggag caggaactga aagtcaagaa ccgttctctg cgctcgctca cccgcagttg 759 tctgtatcac aagagcgaag accaacttca gcgcactctc gaggacgccg aggctctctt 819 caacaagtac tgcgcgctca ctcttaaaga gtagcccgcg cccgcccaca cacggaaaaa 879 ggcgggaatt acgtcaccac ctgcgccctt cgcccgacca tcatcatgag caaagagatt 939 cccacgcctt acatgtggag ctaccagccc cagatgggcc tggccgccgg cgccgcccag 999 gactactcca cccgcatgaa ctggctcagt gccgggcccg cgatgatctc acgggtgaat 1059 gacatccgcg cccaccgaaa ccagatactc ctagaacagt cagcaatcac cgccacgccc 1119 cgccatcacc ttaatccgcg taattggccc gccgccctgg tgtaccagga aattccccag 1179 cccacgaccg tactacttcc gcgagacgcc caggccgaag tccagctgac taactcaggt 1239 gtccagctgg ccggcggcgc cgccctgtgt cgtcaccgcc ccgctcaggg tataaagcgg 1299 ctggtgatcc gaggcagagg cacacagctc aacgacgagg tggtgagctc ttcgctgggt 1359 ctgcgacctg acggagtctt ccaactcgcc ggatcgggga gatcttcctt cacgcctcgt 1419 caggccgtcc tgactttgga gagttcgtcc tcgcagcccc gctcgggtgg catcggcact 1479 ctccagttcg tggaggagtt cactccctcg gtctacttca accccttctc cggctccccc 1539 ggccactacc cggacgagtt catcccgaac ttcgacgcca tcagcgagtc ggtggacggc 1599 tacgattgaa tgtcccatgg tggcgcggct gacctagctc ggcttcgaca cctggaccac 1659 tgccgccgct tccgctgctt cgctcgggat ctcgccgagt ttgcctactt tgagctgccc 1719 gaggagcacc ctcagggccc ggcccacgga gtgcggatcg tcgtcgaagg gggcctcgac 1779 tcccacctgc ttcggatctt cagccagcga ccgatcctgg tcgagcgcga gcaaggacag 1839 acccttctga ccctgtactg catctgcaac cgccccggcc tgc atg aaa gtc ttt 1894 Met Lys Val Phe gtt gtc tgc tgt gta ctg agt ata ata aaa gct gaa atc agc gac tac 1942 Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr 195 200 205 210 tcc gga ctc gat tgt ggt gtt cct gct atc aac cgg tcc ctg ttc ttc 1990 Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg Ser Leu Phe Phe 215 220 225 acc ggg aac gag acc gag ctt cag ctc cag tgt aag ccc cac aag aag 2038 Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys 230 235 240 tac ctc acc tgg ctg ttc cag ggc tct ccg atc gcc gtt gtc aac cac 2086 Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala Val Val Asn His 245 250 255 tgc gac aac gac gga gtc ctg ctg agc ggc cct gcc aac ctt act ttt 2134 Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala Asn Leu Thr Phe 260 265 270 tcc acc cgc aga agc aag ctc cag ctc ttc caa ccc ttc ctc ccc ggg 2182 Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro Phe Leu Pro Gly 275 280 285 290 acc tat cag tgc gtc tcg gga ccc tgc cat cac acc ttc cac ctg atc 2230 Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr Phe His Leu Ile 295 300 305 ccg aat acc aca gcg tcg ctc ccc gct act aac aac caa tct acc cac 2278 Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn Gln Ser Thr His 310 315 320 caa cgc cac cgt cgc gac ctt tcc tct gaa tct aat act acc acc cac 2326 Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn Thr Thr Thr His 325 330 335 acc gga ggt gag ctc cga ggt cga cca acc tct ggg att tac tac ggc 2374 Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly Ile Tyr Tyr Gly 340 345 350 ccc tgg gag gtg gtg ggg tta ata gcg cta ggc cta gtt gtg ggt ggg 2422 Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Val Gly Gly 355 360 365 370 ctt ttg gct ctc tgc tac cta tac ctc cct tgc tgt tcg tac tta gtg 2470 Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys Ser Tyr Leu Val 375 380 385 gtg ctg tgt tgc tgg ttt aag aaa tgg gga aga tca ccc tagtgagctg 2519 Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 390 395 cggtgtgccg gtggcggtgg tggtgctttc gattgtggga ctgggcggcg cggctgtagt 2579 gaaggaggag aaggccgatt cctgcttgca tttcaatccc gacaaatgcc agctgagttt 2639 tcagcccgat ggcaatcggt gcacggtgct gatcaagtgc ggatgggaat gcgagaacgt 2699 gagaatcgag tacaataaca agactcggaa caatactctc gcgtccgtgt ggcagcccgg 2759 ggaccccgag tggtacaccg tctctgtccc cggtgctgac ggctccccgc gcaccgtgaa 2819 taatactttc atttttgcac acatgtgcga cacggtcatg tggatgagca agcagtacga 2879 tatgtggccc cccacgaagg agaacatcgt ggtcttctcc atcgcttaca gcctgtgcac 2939 ggcgctaatc accgctatcg tgtgcctgag cattcacatg ctcatcgcta ttcgccccag 2999 aaataatgcc gagaaagaga aacagccata acacgttttt ttacacacct ttttcagacc 3059 atggcctctg ttactgccct aattattttt ttgggccttg tgggcactag cagcactttt 3119 gatcataaaa acttaactgt ttttgttggt tctgatgtta cactacccgg gcatcaatcg 3179 caccagaggg tttcatggta tcattttaat aaacagaaca cagcttatac actttgcaaa 3239 ggtcatcagc aagccacata tcgcagtggt ctttattaca gatgcaataa caataacctc 3299 acactactct cagttaatgc aaattattct ggcacatact atggaaccaa ttttaacaca 3359 aaacaggaca cttactatag tgtcaaagta ttgaatccaa cctctcctag aactaccact 3419 aagcctaccg ctaccaccac tactactgca aagcccacta aacctaaaac taccaagaaa 3479 accactgtga agactacaac aactagaacc accacaacta cagagaccac caccagcaca 3539 cttgctgcca ctacacacac acacattgag ctaaccttac agaccactaa tgatttgatc 3599 gccctgttgc aaaaggggga taacagcacc acttccgatg aggaaatacc caaatccatg 3659 attggcatta ttgttgctgt agtggtgtgc atgttgatca tcgccttgtg catggtgtac 3719 tatgccttct gctacagaaa gcacagactg aacgacaagc tggaacactt actaagtgtt 3779 gaattttaat tttttagaac catgaagatc ctaggccttt tagttttttc tatcattacc 3839 tctgctcttt gtgaatcggt ggataaagat gttactatta ccactggttc taactataca 3899 ctgaaagggc caccctcagg tatgctttcg tggtattgct attttggaac tgactctgaa 3959 caaactgagc tttgcaatgc aatgagaggc caaatgccaa cctcaaaaat taaacataaa 4019 tgcaatggta ctgatttgat actcctcaat gtcacgaaag catatgctgg cagttacacc 4079 tgccctggag atgatgctga cagtatgatt ttttacaaag taactgttgt tgatcccact 4139 actccaccac ccaccaccac aactactcat accacacaca cagaacaaac accagaggca 4199 gcaggagagt tagccttgca ggttcaggaa gattccctta tggctaatac ccctacaccc 4259 gatcatcggt gtccggggtt gctcgtcagc ggcattgtcg gtgtgctttc gggattagca 4319 gtcataatca tctgcatgtt catttttgct tgctgctata gaaggcttta ccgacaaaaa 4379 tcagacccac tgctgaacct ctatgtttaa ttttttccag agccatgaag gcagttagag 4439 ttctagtttt ttgttctttg attggcattg tttttagtgc tgggtttttg aaaaatctta 4499 ccatttatga aggtgagaat gccactctag tgggcatcag tggtcaaaat gtcagctggc 4559 taaaatacca tctagatagg tggaaagaca tttgcgattg gaatgtcact gtgtatacat 4619 gtaatggagt taacctcacc attactaatg ccacccaaga tcaaaatggt aggtttaagg 4679 gtcagagttt cactagaaat aatgggtatg aatcccataa catgtttatc tatgacgtca 4739 ctgtcatcag aaatgagact gccaccacca ccacacagat gcaaaccaca cagacgacca 4799 catacagtac atcaaatcag cctaccacca ctacagcagc agaggttgcc agctcgtctg 4859 gtgtcaaagt ggcatttttg ttgttgcccc catctagcag tcccactgct agtaccaatg 4919 agcagactac tgaatttttg tccactgtcg agagccacac cacagctacc tcgagtgcct 4979 tctctagcac cgccaatctc tcctcgcttt cctctacacc aatcagttcc gctactacta 5039 ctcctagccc cgctcctctt cccactcccc tgaagcaaac tgaggacagc ggcatgcaat 5099 ggcagatcac cctgctcatt gtgatcgggt tggtcatcct ggccgtgttg ctctactaca 5159 tcttctgccg ccgcattccc aacgcgcacc gcaagccggt ctacaagccc atcattgtcg 5219 ggcagccaga gccgcttcag gtggaagggg gtctaaggaa tcttctcttc tcttttacag 5279 tatggtgatt gaactatgat tcctagacaa ttcttgatca ctattcttat ctgcctcctc 5339 caagtctgtg ccaccctcgc tctggtggcc aacgccagtc cagactgtat tgggcccttc 5399 gcctcctacg tgctctttgc cttcatcacc tgcatctgct gctgtagcat agtctgcctg 5459 cttatcacct tcttccagtt cattgactgg atctttgtgc gcatcgccta cctgcgccac 5519 cacccccagt accgcgacca gcgagtggcg cgactgctca ggctcctctg ataagcatgc 5579 gggctctgct acttctcgcg cttctgctgt tagtgctccc ccgtcccgtc gacccccggt 5639 cccccactca gtcccccgag gaggtccgca aatgcaaatt ccaagaaccc tggaaattcc 5699 tcaaatgcta ccgccaaaaa tcagacatgc atcccagctg gatcatgatc attgggatcg 5759 tgaacattct ggcctgcacc ctcatctcct ttgtgattta cccctgcttt gactttggtt 5819 ggaactcgcc agaggcgctc tatctcccgc ctgaacctga cacaccacca cagcagcaac 5879 ctcaggcaca cgcactacca ccaccacagc ctaggccaca atacatgccc atattagact 5939 atgaggccga gccacagcga cccatgctcc ccgctattag ttacttcaat ctaaccggcg 5999 gag atg act gac cca ctg gcc aac aac aac gtc aac gac ctt ctc ctg 6047 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu 400 405 410 gac atg gac ggc cgc gcc tcg gag cag cga ctc gcc caa ctt cgc att 6095 Asp Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile 415 420 425 430 cgc cag cag cag gag aga gcc gtc aag gag ctg cag gac ggc ata gcc 6143 Arg Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala 435 440 445 atc cac cag tgc aag aaa ggc atc ttc tgc ctg gtg aaa cag gcc aag 6191 Ile His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys 450 455 460 atc tcc tac gag gtc acc cag acc gac cat cgc ctc tcc tac gag ctc 6239 Ile Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu 465 470 475 ctg cag cag cgc cag aag ttc acc tgc ctg gtc gga gtc aac ccc atc 6287 Leu Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile 480 485 490 gtc atc acc cag cag tcg ggc gat acc aag ggg tgc atc cac tgc tcc 6335 Val Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser 495 500 505 510 tgc gac tcc ccc gac tgc gtc cac act ctg atc aag acc ctc tgc ggc 6383 Cys Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly 515 520 525 ctc cgc gac ctc ctc ccc atg aac taa 6410 Leu Arg Asp Leu Leu Pro Met Asn 530 <210> 155 <211> 190 <212> PRT <213> Simian adenovirus 25.2 <400> 155 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Cys Phe Gln Glu Glu Ala Glu 165 170 175 Thr Gln Gln Gln Gln Lys Thr Ser Ser Ser Ser Ser Ser Ser 180 185 190 <210> 156 <211> 209 <212> PRT <213> Simian adenovirus 25.2 <400> 156 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asp Cys Gly Val Pro Ala Ile Asn Arg 20 25 30 Ser Leu Phe Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys 35 40 45 Pro His Lys Lys Tyr Leu Thr Trp Leu Phe Gln Gly Ser Pro Ile Ala 50 55 60 Val Val Asn His Cys Asp Asn Asp Gly Val Leu Leu Ser Gly Pro Ala 65 70 75 80 Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Gln Leu Phe Gln Pro 85 90 95 Phe Leu Pro Gly Thr Tyr Gln Cys Val Ser Gly Pro Cys His His Thr 100 105 110 Phe His Leu Ile Pro Asn Thr Thr Ala Ser Leu Pro Ala Thr Asn Asn 115 120 125 Gln Ser Thr His Gln Arg His Arg Arg Asp Leu Ser Ser Glu Ser Asn 130 135 140 Thr Thr Thr His Thr Gly Gly Glu Leu Arg Gly Arg Pro Thr Ser Gly 145 150 155 160 Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu 165 170 175 Val Val Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Cys 180 185 190 Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser 195 200 205 Pro <210> 157 <211> 135 <212> PRT <213> Simian adenovirus 25.2 <400> 157 Met Thr Asp Pro Leu Ala Asn Asn Asn Val Asn Asp Leu Leu Leu Asp 1 5 10 15 Met Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg 20 25 30 Gln Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Gly Ile Ala Ile 35 40 45 His Gln Cys Lys Lys Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile 50 55 60 Ser Tyr Glu Val Thr Gln Thr Asp His Arg Leu Ser Tyr Glu Leu Leu 65 70 75 80 Gln Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val 85 90 95 Ile Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys 100 105 110 Asp Ser Pro Asp Cys Val His Thr Leu Ile Lys Thr Leu Cys Gly Leu 115 120 125 Arg Asp Leu Leu Pro Met Asn 130 135 <210> 158 <211> 870 <212> DNA <213> Simian adenovirus 25.2 <220> <221> CDS <222> (6)..(573) <223> label=Ela <220> <221> CDS <222> (659)..(864) <223> label=Ela <400> 158 gaaag atg agg cac ctg aga gac ctg ccc ggt aat gtt ttc ctg gct act 50 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr 1 5 10 15 ggg aac gag att ctg gaa ctg gtg gtg gac gcc atg atg ggt gac gac 98 Gly Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp 20 25 30 cct ccg gag ccc cct acc cca ttt gag gcg cct tcg ctg tac gat ttg 146 Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu 35 40 45 tat gat ctg gag gtg gat gtg ccc gag aac gac ccc aac gag gag gcg 194 Tyr Asp Leu Glu Val Asp Val Pro Glu Asn Asp Pro Asn Glu Glu Ala 50 55 60 gtg aat gat ttg ttt agc gat gcc gcg ctg ctg gct gcc gag cag gct 242 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala 65 70 75 aat acg gac tct ggc tca gac agc gat tcc tct ctc cat acc ccg aga 290 Asn Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg 80 85 90 95 ccc ggc aga ggt gag aaa aag atc ccc gag ctt aaa ggg gaa gag ctc 338 Pro Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu 100 105 110 gac ctg cgc tgc tat gag gaa tgc ttg cct ccg agc gat gat gag gag 386 Asp Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu 115 120 125 gac gag gag gcg att cga gct gca gcg aac cag gga gtg aaa gcg gcg 434 Asp Glu Glu Ala Ile Arg Ala Ala Ala Asn Gln Gly Val Lys Ala Ala 130 135 140 ggc gag ggc ttt agc ctg gac tgt cct act ctg ccc gga cac ggc tgt 482 Gly Glu Gly Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys 145 150 155 aag tct tgt gaa ttt cat cgc atg aat act gga gat aag aat gtg atg 530 Lys Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met 160 165 170 175 tgt gcc ctg tgc tat atg aga gct tac aac cat tgt gtt tac a 573 Cys Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr 180 185 gtaagtgtga ttaactttag ttgggaaggc agagggtgac tgggtgctga ctggtttatt 633 tatgtatatg tttttttatg tgtag gt ccc gtc tct gac gta gat gag acc 684 Ser Pro Val Ser Asp Val Asp Glu Thr 195 ccc act tca gag tgc att tca tca ccc cca gaa att ggc gag gaa ccg 732 Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro Glu Ile Gly Glu Glu Pro 200 205 210 ccc gaa gat att att cat aga cca gtt gca gtg aga gtc acc ggg cgg 780 Pro Glu Asp Ile Ile His Arg Pro Val Ala Val Arg Val Thr Gly Arg 215 220 225 230 aga gca gct gtg gag agt ttg gat gac ttg cta cag ggt ggg gat gaa 828 Arg Ala Ala Val Glu Ser Leu Asp Asp Leu Leu Gln Gly Gly Asp Glu 235 240 245 cct ttg gac ttg tgt acc cgg aaa cgc ccc agg cac taagtg 870 Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg His 250 255 <210> 159 <211> 258 <212> PRT <213> Simian adenovirus 25.2 <400> 159 Met Arg His Leu Arg Asp Leu Pro Gly Asn Val Phe Leu Ala Thr Gly 1 5 10 15 Asn Glu Ile Leu Glu Leu Val Val Asp Ala Met Met Gly Asp Asp Pro 20 25 30 Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu Tyr Asp Leu Tyr 35 40 45 Asp Leu Glu Val Asp Val Pro Glu Asn Asp Pro Asn Glu Glu Ala Val 50 55 60 Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Gln Ala Asn 65 70 75 80 Thr Asp Ser Gly Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Leu Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Glu Asp 115 120 125 Glu Glu Ala Ile Arg Ala Ala Ala Asn Gln Gly Val Lys Ala Ala Gly 130 135 140 Glu Gly Phe Ser Leu Asp Cys Pro Thr Leu Pro Gly His Gly Cys Lys 145 150 155 160 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Asn Val Met Cys 165 170 175 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val 180 185 190 Ser Asp Val Asp Glu Thr Pro Thr Ser Glu Cys Ile Ser Ser Pro Pro 195 200 205 Glu Ile Gly Glu Glu Pro Pro Glu Asp Ile Ile His Arg Pro Val Ala 210 215 220 Val Arg Val Thr Gly Arg Arg Ala Ala Val Glu Ser Leu Asp Asp Leu 225 230 235 240 Leu Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro 245 250 255 Arg His <210> 160 <211> 860 <212> DNA <213> Simian adenovirus 25.2 <220> <221> CDS <222> (10)..(337) <223> label=33K <220> <221> CDS <222> (507)..(850) <223> label=33K <400> 160 tcccccagg atg ccc cga gga agc agc aag aag ctg aaa gtg gag ctg ccg 51 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro 1 5 10 ctg ccg ccg gag gat ttg gag gaa gac tgg gag agc agt cag gca gag 99 Leu Pro Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu 15 20 25 30 gag atg gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa 147 Glu Met Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln 35 40 45 gac agt ctg gag gag gaa gac gag gtg gag gag gag gca gag gaa gaa 195 Asp Ser Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu 50 55 60 gca gcc gcc gcc aga ccg tcg tcc tcg gcg gag aaa gca agc agc acg 243 Ala Ala Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt cgc ggc ggc cgg gcc cac agt 291 Asp Thr Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser 80 85 90 aga tgg gac gag acc ggg cgc ttc cca aac ccc acc acc cag acc g 337 Arg Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 95 100 105 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 397 gcttgcaagc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 457 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 514 Ala Pro Thr act gtt tcc aag aag agg cag aaa ccc agc agc agc aga aaa cca gca 562 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 gca gca gca gca gca gct aga aaa tcc aca gcg gcg gcg gca ggt gga 610 Ala Ala Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Ala Gly Gly 130 135 140 ctg agg atc gcg gcg aac gag ccg gcg cag acc cgg gag ctg agg aac 658 Leu Arg Ile Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn 145 150 155 160 cgg atc ttt ccc acc ctc tat gcc atc ttc cag cag agt cgg ggg cag 706 Arg Ile Phe Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln 165 170 175 gag cag gaa ctg aaa gtc aag aac cgt tct ctg cgc tcg ctc acc cgc 754 Glu Gln Glu Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg 180 185 190 agt tgt ctg tat cac aag agc gaa gac caa ctt cag cgc act ctc gag 802 Ser Cys Leu Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu 195 200 205 gac gcc gag gct ctc ttc aac aag tac tgc gcg ctc act ctt aaa gag 850 Asp Ala Glu Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 tagcccgcgc 860 <210> 161 <211> 224 <212> PRT <213> Simian adenovirus 25.2 <400> 161 Met Pro Arg Gly Ser Ser Lys Lys Leu Lys Val Glu Leu Pro Leu Pro 1 5 10 15 Pro Glu Asp Leu Glu Glu Asp Trp Glu Ser Ser Gln Ala Glu Glu Met 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Glu Asp Glu Val Glu Glu Glu Ala Glu Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Glu Lys Ala Ser Ser Thr Asp Thr 65 70 75 80 Ile Ser Ala Pro Gly Arg Gly Arg Gly Gly Arg Ala His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro Thr 100 105 110 Thr Val Ser Lys Lys Arg Gln Lys Pro Ser Ser Ser Arg Lys Pro Ala 115 120 125 Ala Ala Ala Ala Ala Ala Arg Lys Ser Thr Ala Ala Ala Ala Gly Gly 130 135 140 Leu Arg Ile Ala Ala Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn 145 150 155 160 Arg Ile Phe Pro Thr Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln 165 170 175 Glu Gln Glu Leu Lys Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg 180 185 190 Ser Cys Leu Tyr His Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu 195 200 205 Asp Ala Glu Ala Leu Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 220 <210> 162 <211> 36628 <212> DNA <213> Simian adenovirus 26 <220> <221> repeat_region <222> (1)..(131) <223> label=ITR <220> <221> CDS <222> (1908)..(3404) <223> label=Elb\55K <220> <221> CDS <222> (3492)..(3917) <223> label=pIX <220> <221> misc_feature <222> (3982)..(5603) <223> complement (3982...5312, 5591...5603) label=IVa2 <220> <221> misc_feature <222> (5085)..(13842) <223> complement (5085 ...8663, 13834 ...13842) label=pol <220> <221> misc_feature <222> (8465)..(13842) <223> complement (8465...10399, 13834...13842) label=pTP <220> <221> CDS <222> (10612)..(12003) <223> label=52K <220> <221> CDS <222> (12030)..(13805) <223> label=pIIIa <220> <221> CDS <222> (13884)..(15521) <223> label=penton <220> <221> CDS <222> (15528)..(16106) <223> label=pVII <220> <221> CDS <222> (16151)..(17167) <223> label=V <220> <221> CDS <222> (17195)..(17428) <223> label=pX <220> <221> CDS <222> (17461)..(18234) <223> label=PVI <220> <221> CDS <222> (18344)..(21154) <223> label=hexon <220> <221> CDS <222> (21176)..(21802) <223> label=protease <220> <221> misc_feature <222> (21885)..(23423) <223> complement label=DBP <220> <221> CDS <222> (23449)..(25854) <223> label=100K <220> <221> CDS <222> (26482)..(27162) <223> label=pVIII <220> <221> CDS <222> (27166)..(27483) <223> label=E3\12.5K <220> <221> CDS <222> (28057)..(28584) <223> label=E3\gp19K <220> <221> CDS <222> (28618)..(29355) <223> label=E3\CR1-beta <220> <221> CDS <222> (29371)..(29988) <223> label=E3\CR1-gamma <220> <221> CDS <222> (30011)..(30883) <223> label=E3\CR1-delta <220> <221> CDS <222> (30895)..(31167) <223> label=E3\RID-alpha <220> <221> CDS <222> (31170)..(31613) <223> label=E3\RID-beta <220> <221> CDS <222> (32264)..(33538) <223> label=fiber <220> <221> misc_feature <222> (33635)..(34779) <223> complement (33635...33883, 34630...34779) label=E4\orf6/7 <220> <221> misc_feature <222> (33883)..(34779) <223> complement label=E4\orf6 <220> <221> misc_feature <222> (34685)..(35050) <223> complement label=E4\orf4 <220> <221> misc_feature <222> (35062)..(35412) <223> complement label=E4\orf3 <220> <221> misc_feature <222> (35412)..(35798) <223> complement label=E4\orf2 <220> <221> misc_feature <222> (35851)..(36222) <223> complement label=E4\orf1 <220> <221> repeat_region <222> (36498)..(36628) <223> complement label=ITR <400> 162 catcatcaat aatatacctc aaactttttg tgcgcgttaa tatgcaaatg aggcgtttga 60 atttggggag gaagggttgt gattggctgc gggaagggcg accgttaggg gcggggcgag 120 tgacgttttt atgacgtggc cgtgaggagg agctagcttg caagttcttg tgggaaaagt 180 gacgttaaac gaggtgtggt ttgaacacgg aaatacttaa ttttcccgcg ctctttgaca 240 ggaaatgagg tgtttctggg cggatgcaag tgaaaacggg ccattttcgc gcgaaaactg 300 aatgaggaag tgaaaatctg agtaatttcg cgtttatgac agggaggagt atttgccgag 360 ggccgagtag actttgaccg attacgtggg ggtttcgatt accgtgtttt tcacctaaat 420 ttccgcgtac ggtgtcaaag tccggtgttt ttacgtaggt gtcagctgat cgccagggta 480 tttaaacctg cgctctccag tcaagaggcc actcttgagt gccagcgaga agagttttct 540 cctccgcgcc gcgagtcaga tctacacttt gaaagatgag gcacctgaga gacctgcccg 600 atgagaaaat catcatcgct tccgggaacg agattctgga actggtggta aatgccatga 660 tgggcgacga ccctccggag ccccccaccc catttgaggc accttcgctg cacgatttgt 720 atgatctgga ggtggatgtg cccgatgacg accccaacga ggaggcggta aatgatttat 780 ttagcgatgc cgcgctgcta gctgccgagg aggcttcgag ccctagctca gacagcgact 840 cttcactgca tacccctaga cctggcagag gtgagaaaaa gatccccgag cttaaagggg 900 aagagatgga cttgcgctgc tatgaggaat gcttgccccc gagcgatgat gaggacgagc 960 aggcgatcca gaacgcagcg agccagggag tgcaagccgc cagcgagagc tttgcgctgg 1020 actgcccgcc tctgcccgga cacggctgta agtcttgtga atttcatcgc atgaatactg 1080 gagataaagc tgtgttgtgt gcactttgct atatgagagc ttacaaccat tgtgtttaca 1140 gtaagtgtga ttaagttgaa ctttagaggg aggcagagag cagggtgact gggcgatgac 1200 tggtttattt atgtatatat atgttcttta tataggtccc gtctctgacg cagatgatga 1260 gacccccact acagagtcca cttcgtcacc cccagaaatt ggcacatctc cacctgagaa 1320 tattgttaga ccagttcctg ttagagccac tgggaggaga gcagctgtgg aatgtttgga 1380 tgacttgcta cagggtgggg atgaaccttt ggacttgtgt acccggaaac gccccaggca 1440 ctaagtgcca cacatgtgtg tttacttgag gtgatgtcag tatttatagg gtgtggagtg 1500 caataaaaaa tgtgttgact ttaagtgcgt ggtttatgac tcaggggtgg ggactgtggg 1560 tatataagca ggtgcagacc tgtgtggtta gctcagagcg gcatggagat ttggacggtc 1620 ttggaagact ttcacaagac tagacagctg ctagagaacg cctcgaacgg agtctcttac 1680 ctgtggagat tctgcttcgg tggcgaccta gctaggctag tctatagggc caaacaggat 1740 tatagtgaac aatttgaggt tattttgaga gagtgttctg gtctttttga cgctcttaac 1800 ttgggccatc agtctcactt taaccagagg atttcgagag cccttgactt tactactcct 1860 ggcagaacca ctgcggcagt agcctttttt gcttttcttc ttgacaa atg gag tca 1916 Met Glu Ser 1 aga aac cca ttt cag cag gga tta cca gct gga ttt ctt agc agt agc 1964 Arg Asn Pro Phe Gln Gln Gly Leu Pro Ala Gly Phe Leu Ser Ser Ser 5 10 15 ttt gtg gag aac atg gaa gtg cca gcg cct gaa tgc aat ctc agg cta 2012 Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn Leu Arg Leu 20 25 30 35 ctt gcc ggt aca gcc gct aga cac tct gag gat cct gaa tct cca gga 2060 Leu Ala Gly Thr Ala Ala Arg His Ser Glu Asp Pro Glu Ser Pro Gly 40 45 50 gag tcc cag ggc aca cca acg tcg cca gca gca gca gcg gca gca gga 2108 Glu Ser Gln Gly Thr Pro Thr Ser Pro Ala Ala Ala Ala Ala Ala Gly 55 60 65 gga gga tca aga aga gaa ccc gag agc cgg cct gga ccc tcc gga gga 2156 Gly Gly Ser Arg Arg Glu Pro Glu Ser Arg Pro Gly Pro Ser Gly Gly 70 75 80 gga gga gta gct gac ctg ttt cct gaa ctg cgc cgg gtg ctg act agg 2204 Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val Leu Thr Arg 85 90 95 tct tcg agt ggt cgg gag agg ggg att aag cgg gag agg cat gat gag 2252 Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg His Asp Glu 100 105 110 115 act aat cac aga act gaa ctg act gtg ggt ctg atg agc cgc aag cgt 2300 Thr Asn His Arg Thr Glu Leu Thr Val Gly Leu Met Ser Arg Lys Arg 120 125 130 cca gaa aca gtg tgg tgg cat gag gtg cag tcg act ggc aca gat gag 2348 Pro Glu Thr Val Trp Trp His Glu Val Gln Ser Thr Gly Thr Asp Glu 135 140 145 gtg tca gtg atg cat gag agg ttt tcc cta gaa caa gtc aag act tgt 2396 Val Ser Val Met His Glu Arg Phe Ser Leu Glu Gln Val Lys Thr Cys 150 155 160 tgg tta gag cct gag gat gat tgg gag gta gcc atc agg aat tat gcc 2444 Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg Asn Tyr Ala 165 170 175 aag ctg gct ctc agg cca gac aag aag tac aag att act aag ctg ata 2492 Lys Leu Ala Leu Arg Pro Asp Lys Lys Tyr Lys Ile Thr Lys Leu Ile 180 185 190 195 aat atc aga aat gcc tgc tac atc tca ggg aat ggg gct gaa gtg gag 2540 Asn Ile Arg Asn Ala Cys Tyr Ile Ser Gly Asn Gly Ala Glu Val Glu 200 205 210 atc tgt ctt cag gat aga gtg gct ttc aga tgc tgt atg atg aat atg 2588 Ile Cys Leu Gln Asp Arg Val Ala Phe Arg Cys Cys Met Met Asn Met 215 220 225 tac ccg gga gtg gtg ggc atg gat ggg gtc acc ttt atg aac atg agg 2636 Tyr Pro Gly Val Val Gly Met Asp Gly Val Thr Phe Met Asn Met Arg 230 235 240 ttc agg gga gat ggg tat aat ggt acg gtc ttt atg gcc aat acc aag 2684 Phe Arg Gly Asp Gly Tyr Asn Gly Thr Val Phe Met Ala Asn Thr Lys 245 250 255 ctg aca gtc cat ggc tgc tcc ttc ttt ggg ttt aat aac acc tgc att 2732 Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn Thr Cys Ile 260 265 270 275 gag gcc tgg ggc cag gtt ggt gtg agg ggc tgt agt ttt tca gcc aac 2780 Glu Ala Trp Gly Gln Val Gly Val Arg Gly Cys Ser Phe Ser Ala Asn 280 285 290 tgg atg ggg gtc gtg ggc agg acc aag agt atg ctg tct gtg aag aaa 2828 Trp Met Gly Val Val Gly Arg Thr Lys Ser Met Leu Ser Val Lys Lys 295 300 305 tgc ttg ttc gag agg tgc cac ctg ggg gtg atg agc gag ggc gaa gcc 2876 Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser Glu Gly Glu Ala 310 315 320 aga atc cgc cac tgc gcc tct acc gag acg ggc tgc ttt gtg ctg tgc 2924 Arg Ile Arg His Cys Ala Ser Thr Glu Thr Gly Cys Phe Val Leu Cys 325 330 335 aag ggc aat gct aag atc aag cat aat atg att tgt gga gcc tcg gac 2972 Lys Gly Asn Ala Lys Ile Lys His Asn Met Ile Cys Gly Ala Ser Asp 340 345 350 355 gag cgc ggc tac cag atg ctg acc tgc gcc ggg ggg aac agc cat atg 3020 Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn Ser His Met 360 365 370 ctg gcc acc gtg cat gtg gct tcc cat tcc cgc aag ccc tgg ccc gag 3068 Leu Ala Thr Val His Val Ala Ser His Ser Arg Lys Pro Trp Pro Glu 375 380 385 ttc gag cac aat gtc atg acc agg tgc aat atg cat ctg ggg tct cgc 3116 Phe Glu His Asn Val Met Thr Arg Cys Asn Met His Leu Gly Ser Arg 390 395 400 cga ggc atg ttc atg ccc tac cag tgc aac ctg aat tat gtg aag gtg 3164 Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Leu Asn Tyr Val Lys Val 405 410 415 ctg ctg gag cct gat gcc atg tcc aga gtg agc ctg acg ggg gtg ttt 3212 Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Thr Gly Val Phe 420 425 430 435 gac atg aat gtg gag gtg tgg aag att ctg aga tat gat gaa tcc aag 3260 Asp Met Asn Val Glu Val Trp Lys Ile Leu Arg Tyr Asp Glu Ser Lys 440 445 450 acc agg tgc cga gcc tgc gag tgc gga ggg aag cat gcc agg ttc cag 3308 Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala Arg Phe Gln 455 460 465 ccc gtg tgt gtg gag gtg acg gag gac ctg cga ccc gat cat ttg gtg 3356 Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro Asp His Leu Val 470 475 480 ttg tcc tgc acc ggg acg gag ttc ggt tcc agc ggg gaa gaa tct gac 3404 Leu Ser Cys Thr Gly Thr Glu Phe Gly Ser Ser Gly Glu Glu Ser Asp 485 490 495 tagagtgagt agtgttctgg ggcgggggag ggcctgcatg aggggcagaa tgactgaaat 3464 ctgtgctttt ctgtgtgttg cagcagc atg agc gga agc ggc tcc ttt gag gga 3518 Met Ser Gly Ser Gly Ser Phe Glu Gly 500 505 ggg gta ttc agc cct tat ctg acg ggg cgt ctc ccc tcc tgg gcg gga 3566 Gly Val Phe Ser Pro Tyr Leu Thr Gly Arg Leu Pro Ser Trp Ala Gly 510 515 520 gtg cgt cag aat gtg atg gga tcc acg gtg gac ggc cgg ccc gtg cag 3614 Val Arg Gln Asn Val Met Gly Ser Thr Val Asp Gly Arg Pro Val Gln 525 530 535 540 ccc gcg aac tct tca acc ctg acc tat gca acc ctg agc tct tcg tcg 3662 Pro Ala Asn Ser Ser Thr Leu Thr Tyr Ala Thr Leu Ser Ser Ser Ser 545 550 555 gtg gac gca gct gcc gcc gca gct gct gca tct gcc gcc agc gcc gtg 3710 Val Asp Ala Ala Ala Ala Ala Ala Ala Ala Ser Ala Ala Ser Ala Val 560 565 570 cgc gga atg gcc atg ggc gcc ggc tac tac ggc act ctg gtg gcc aac 3758 Arg Gly Met Ala Met Gly Ala Gly Tyr Tyr Gly Thr Leu Val Ala Asn 575 580 585 tcg agt tcc acc aat aat ccc gcc agc ctg aac gag gag aag ctg ctg 3806 Ser Ser Ser Thr Asn Asn Pro Ala Ser Leu Asn Glu Glu Lys Leu Leu 590 595 600 ctg ctg atg gcc cag ctc gag gcc ttg acc cag cgc ctg ggc gag ctg 3854 Leu Leu Met Ala Gln Leu Glu Ala Leu Thr Gln Arg Leu Gly Glu Leu 605 610 615 620 acc cag cag gtg gct cag ctg cag gag cag acg cgg gcc gcg gtt gcc 3902 Thr Gln Gln Val Ala Gln Leu Gln Glu Gln Thr Arg Ala Ala Val Ala 625 630 635 acg gtg aaa tcc aaa taaaaaatga atcaataaat aaacggagac ggttgttgat 3957 Thr Val Lys Ser Lys 640 tttaacacag agtctgaatc tttatttgat ttttcgcgcg cggtaggccc tggaccaccg 4017 gtctcgatca ttgagcaccc ggtggatctt ttccaggacc cggtagaggt gggcttggat 4077 gttgaggtac atgggcatga gcccgtcccg ggggtggagg tagctccatt gcagggcctc 4137 atgctcgggg gtggtgttgt aaatcaccca gtcatagcag gggcgcaggg catggtgttg 4197 cacaatatct ttgaggagga gactgatggc cacgggcagc cctttggtgt aggtgtttac 4257 aaatctgttg agctgggagg gatgcatgcg gggggagatg aggtgcatct tggcctggat 4317 cttgagattg gcgatgttac cgcccagatc ccgcctgggg ttcatgttgt gcaggaccac 4377 cagcacggtg tatccggtgc acttggggaa tttatcatgc aacttggaag ggaaggcgtg 4437 aaagaatttg gcgacgccct tgtgcccgcc caggttttcc atgcactcat ccatgatgat 4497 ggcgatgggc ccgtgggcgg cggcctgggc aaagacgttt cgggggtcgg acacatcata 4557 gttgtggtcc tgggtgagat catcataggc cattttaatg aatttggggc ggagggtgcc 4617 ggactggggg acaaaggtac cctcgatccc gggggcgtag ttcccctcac agatctgcat 4677 ctcccaggct ttgagctcgg agggggggat catgtccacc tgcggggcga taaagaacac 4737 ggtttccggg gcgggggaga tgagctgggc cgaaagcaag ttccggagca gctgggactt 4797 gccgcagccg gtggggccgt agatgacccc gatgaccggc tgcaggtggt agttgaggga 4857 gagacagctg ccgtcctcgc ggaggagggg ggccacttcg ttcatcatct cgcgcacatg 4917 catgttctcg cgcaccagtt ccgccaggag gcgctctccc cccagggata ggagctcctg 4977 gagcgaggcg aagtttttca gcggcttgag tccgtcggcc atgggcattt tggagagggt 5037 ctgttgcaag agttccaagc ggtcccagag ctcggtgatg tgctctacgg catctcgatc 5097 cagcagacct cctcgtttcg cgggttggga cggctgcggg agtagggcac cagacgatgg 5157 gcgtccagcg cagccagggt ccggtccttc cagggccgca gcgtccgcgt cagggtggtc 5217 tccgtcacgg tgaaggggtg cgcgccgggc tgggcgcttg cgagggtgcg cttcaggctc 5277 atccggctgg tcgaaaaccg ctcccgatcg gcgccctgcg cgtcggccag gtagcaattg 5337 accatgagtt cgtagttgag cgcctcggcc gcgtggcctt tggcgcggag cttacctttg 5397 gaagtctgcc cgcaggcggg acagaggagg gacttgaggg cgtagagctt gggggcgagg 5457 aagacggact cgggggcgta ggcgtccgcg ccgcagtggg cgcagacggt ctcgcactcc 5517 acgagccagg tgaggtcggg ctggtcgggg tcaaaaacca gtttcccgcc gttctttttg 5577 atgcgtttct tacctttggt ctccatgagc tcgtgtcccc gctgggtgac aaagaggctg 5637 tccgtgtccc cgtagaccga ctttatgggc cggtcctcga gcggtgtgcc gcggtcctcc 5697 tcgtagagga accccgccca ctccgagacg aaagcccggg tccaggccag cacgaaggag 5757 gccacgtggg acgggtagcg gtcgttgtcc accagcgggt ccactttctc cagggtatgc 5817 aaacacatgt ccccctcgtc cacatccagg aaggtgattg gcttgtaagt gtaggccacg 5877 tgaccggggg tcccggccgg gggggtataa aagggggcgg gcccctgctc gtcctcactg 5937 tcttccggat cgctgtccag gagcgccagc tgttggggta ggtattccct ctcgaaggcg 5997 ggcatgacct cggcactcag gttgtcagtt tctagaaacg aggaggattt gatattgacg 6057 gtgccggcgg agatgccttt caagagcccc tcgtccatct ggtcagaaaa gacgatcttt 6117 ttgttgtcga gtttggtggc gaaggagccg tagagggcgt tggaaaggag cttggcgatg 6177 gagcgcatgg tctggttctt ttccttgtcg gcgcgctcct tggccgcgat gttgagctgc 6237 acgtactcgc gcgccacaca cttccattcg gggaagacgg tggtcagctc gtcgggcacg 6297 attctgacct gccagccccg attatgcagg gtgatgaggt ccacactggt ggccacctcg 6357 ccgcgcaggg gctcgttggt ccagcagagg cgcccgccct tgcgcgagca gaaggggggc 6417 agggggtcca gcatgacctc gtcggggggg tcggcatcga tggtgaagat gccgggcagg 6477 aggtcggggt caaagtagct gatggaagtg tccagatcgt ccagggcagc ttgccattcg 6537 cgcacggcca gcgcgcgctc gtagggactg aggggcgtgc cccagggcat ggggtgggtg 6597 agcgcggagg cgtacatgcc gcagatgtcg tagacgtaga ggggctcctc gaggatgccg 6657 atgtaggtgg ggtagcagcg ccccccgcgg atgctggcgc gcacgtagtc atacagctcg 6717 tgcgaggggg cgaggagccc cgggcccagg ttggtgcgac tgggcttttc ggcgcggtag 6777 acgatctggc ggaagatggc gtgcgagttg gaggagatgg tgggcctttg gaagatgttg 6837 aagtgggcgt gggggagacc gaccgagtcg cggaggaagt gggcgtagga gtcttgcagc 6897 ttggcgacga gctcggcggt gacgaggacg tccagagcgc agtagtcgag ggtctcctgg 6957 atgatgtcat acttgagctg gcccttttgt ttccacagct cgcggttgag aaggaactct 7017 tcgcggtcct tccagtactc ttcgaggggg aacccgtcct gatctgcacg gtaagagcct 7077 agcatgtaga actggttgac ggccttgtag gcgcagcagc ccttctccac ggggagggcg 7137 taggcctggg cggccttgcg cagggaggtg tgcgtgaggg cgaaagtgtc cctgaccatg 7197 accttgagga actggtgctt gaagtcgata tcgtcgcagc ccccctgctc ccagagctgg 7257 aagtccgtgc gctttttgta ggcggggttg ggcaaagcga aagtaacatc gttgaagagg 7317 atcttgcccg cgcggggcat aaagttgcga gtgatgcgga aaggctgggg cacctcggcc 7377 cggttgttga tgacctgggc ggcgagcacg atctcgtcga agccgttgat gttgtggccc 7437 acgatgtaga gttccactaa tcgcgggcgg cccttgacgt ggggcagttt cttgagctcc 7497 tcgtaggtga gctcgtcggg gtcgctgagg ccgtactgct cgagcgccca gtcggcgaga 7557 tgggggttgg cgcggaggaa ggaagtccag agatccacgg ccagggcggt ctgcaggcgg 7617 tcccggtact gacggaactg ctgcccgacg gccatttttt cgggggtgac gcagtagaag 7677 gtgcgggggt ccccgtgcca gcgatcccat ttgagctgga gggcgagatc gagggcgagc 7737 tcgacgagcc ggtcgtcccc ggagagtttc atgaccagca tgaaggggac gagctgcttg 7797 ccgaaggacc ccatccaggt gtaggtttcc acatcgtagg tgaggaagag cctttcggtg 7857 cgaggatgcg agccgatggg gaagaactgg atctcctgcc accaattgga ggaatggctg 7917 ttgatgtgat ggaagtagaa atgccgacgg cgcgccgaac actcgtgctt gtgtttatac 7977 aagcggccac agtgctcgca acgctgcacg ggatgcacgt gctgcacgag ctgtacctga 8037 gttcctttga cgaggaattt cagtgggaag tggagtcgtg gcgcctgcat ctcgtgctgt 8097 actacgtcgt ggtggtcggc ctggccctct tctgcctcga tggtggtcat gctgacgagc 8157 ccgcgcggga ggcaggtcca gacctcggcg cgagcgggtc ggagagcgag gacgagggcg 8217 cgcaggccgg agctgtccag ggtcctgaga cgctgcggag tcaggtcagt gggcagcggc 8277 ggcgcgcggt tgacttgcag gagtttttcc agggcgcgcg ggaggtccag atggtacttg 8337 atctccaccg cgccgttggt ggcgacgtcg atggcttgca gggtcccgtg cccctggggt 8397 gtgaccaccg tcccccgttt cttcttgggc ggctggggcg acgggggcgg tacttcttcc 8457 atggttagaa gcggcggcga ggacgcgcgc cgggcggcag aggcggctcg gggcccggag 8517 gcaggggcgg caggggcacg tcggcgccgc gcgcgggtag gttctggtac tgcgcccgga 8577 gaagactggc gtgagcgacg acgcgacggt tgacgtcctg gatctgacgc ctctgggtga 8637 aggccacggg acccgtgagt ttgaacctga aagagagttc gacagaatca atctcggtat 8697 cgttgacggc ggcctgccgc aggatctctt gcacgtcgcc cgagttgtcc tggtaggcga 8757 tctcggtcat gaactgctcg atctcctcct cctgaaggtc tccgcggccg gcgcgctcca 8817 cggtggccgc gaggtcgttg gagatgcggc ccatgagctg cgagaaggcg ttcatgcccg 8877 cctcgttcca gacgcggctg tagaccacga cgccctcggg atcgcgggcg cgcatgacca 8937 cctgggcgag gttgagctcc acgtggcgcg tgaagaccgc gtagttgcag aggcgctggt 8997 agaggtagtt gagcgtggtg gcgatgtgct cggtgacgaa gaaatacatg atccagcgac 9057 ggagcggcat ctcgctgacg tcgcccagcg cctccaaacg ttccatggcc tcgtaaaagt 9117 ccacggcgaa gttgaaaaac tgggagttgc gcgccgagac ggtcaactcc tcctccagaa 9177 gacggatgag ctcggcgatg gtggcgcgca cctcgcgctc gaaggccccc gggagttcct 9237 cctcttccat ctcttcttct acctcctcca ctaacatctc ttctacttcc tcctcaggcg 9297 gtggtggcgg gggagggggc ctgcgtcgcc ggcggcgcac gggcagacgg tcgatgaagc 9357 gctcgatggt ctcgccgcgc cggcgtcgca tggtctcggt gacggcgcgc ccgtcctcgc 9417 ggggccgcag cgtgaagacg ccgccgcgca tctccaggtg gccggggggg tccccgttgg 9477 gcagggagag ggcgctgacg atgcatctta tcaattgccc cgtagggact ccgcgcaagg 9537 acctgagcgt ctcgagatcc acgggatctg aaaaccgttg aacgaaggct tcgagccagt 9597 cgcagtcgca aggtaggctg agcacggttt cttccggcgg gtcatgttgg ttggagggag 9657 cggggcgggc gatgctgctg gtgatgaagt tgaaataggc ggttctgaga cggcggatgg 9717 tggcgaggag caccaggtct ttgggcccgg cttgctggat gcgcagacgg tcggccatgc 9777 cccaggcgtg gtcctgacac ctggccaggt ccttgtagta gtcctgcatg agccgctcca 9837 cgggcacctc ctcctcgccc gcgcggccgt gcatgcgcgt gagcccgaag ccgcgctggg 9897 gctggacgag cgccaggtcg gcgacgacgc gctcggcgag gatggcctgc tgaatctggg 9957 tgagggtggt ctggaagtcg tcaaagtcga cgaagcggtg gtaggctccg gtgttgatgg 10017 tgtaggagca gttggccatg acggaccagt tgacggtctg gtggcccgga cgcacgagct 10077 cgtggtactt gaggcgcgag taggcgcgcg tgtcgaagat gtagtcgttg caggtgcgca 10137 ccaggtactg gtagccgatg aggaagtgcg gcggcggctg gcggtagagc ggccatcgct 10197 cggtggcggg ggcgccgggc gcgaggtcct cgagcatggt gcggtggtag ccgtagatgt 10257 acctggacat ccaggtgatg ccggcggcgg tggtggaggc gcgcgggaac tcgcggacgc 10317 ggttccagat gttgcgcagc ggcaggaagt agttcatggt gggcacggtc tggcccgtga 10377 ggcgcgcgca gtcgtggatg ctctatacgg gcaaaaacga aagcggtcag cggctcgact 10437 ccgtggcctg gaggctaagc gaacgggttg ggctgcgcgt gtaccccggt tcgaatctcg 10497 aatcaggctg gagccgcagc taacgtggta ctggcactcc cgtctcgacc caagcctgca 10557 caaaacctcc aggatacgga ggcgggtcgt tttgcaactt tttttggagg ccgg atg 10614 Met aaa cta gta agc gca gaa agc ggc cga ccg cga tgg ctc gct gcc gta 10662 Lys Leu Val Ser Ala Glu Ser Gly Arg Pro Arg Trp Leu Ala Ala Val 645 650 655 gtc tgg aga aga atc gcc agg gtt gcg ttg cgg tgt gcc ccg gtt cga 10710 Val Trp Arg Arg Ile Ala Arg Val Ala Leu Arg Cys Ala Pro Val Arg 660 665 670 agc cgg ccg gat tcc gcg gct aac gag ggc gtg gct gcc ccg tcg ttt 10758 Ser Arg Pro Asp Ser Ala Ala Asn Glu Gly Val Ala Ala Pro Ser Phe 675 680 685 690 cca aga ccc cct agc cag ccg act tct cca gtt acg gag cga gcc cct 10806 Pro Arg Pro Pro Ser Gln Pro Thr Ser Pro Val Thr Glu Arg Ala Pro 695 700 705 ctt ttg ttt ttt tgt ttt tgc cag atg cat ccc gta ctg cgg cag atg 10854 Leu Leu Phe Phe Cys Phe Cys Gln Met His Pro Val Leu Arg Gln Met 710 715 720 cgc ccc cac cac cct cca ccg caa caa cag ccc cct cca cag ccg gcg 10902 Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro Pro Gln Pro Ala 725 730 735 ctt ctg ccc ccg ccc cag cag cag cag caa ctt cca gcc acg acc gcc 10950 Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln Leu Pro Ala Thr Thr Ala 740 745 750 gcg gcc gcc gtg agc ggg gct gga cag act tct cag tat gac ctg gcc 10998 Ala Ala Ala Val Ser Gly Ala Gly Gln Thr Ser Gln Tyr Asp Leu Ala 755 760 765 770 ttg gaa gag ggc gag ggg ctg gcg cgc ctg ggg gcg tcg tcg ccg gag 11046 Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro Glu 775 780 785 cgg cac ccg cgc gtg cag atg aaa agg gac gct cgc gag gcc tac gtg 11094 Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr Val 790 795 800 ccc aag cag aac ctg ttc aga gac agg agc ggc gag gag ccc gag gag 11142 Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu Glu 805 810 815 atg cgc gcg gcc cgg ttc cac gcg ggg cgg gag ctg cgg cgc ggc ctg 11190 Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly Leu 820 825 830 gac cga aag agg gtg ctg agg gac gag gat ttc gag gcg gac gag ctg 11238 Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu Leu 835 840 845 850 acg ggg atc agc ccc gcg cgc gcg cac gtg gcc gcg gcc aac ctg gtc 11286 Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu Val 855 860 865 acg gcg tac gag cag acc gtg aag gag gag agc aac ttc caa aaa tcc 11334 Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys Ser 870 875 880 ttc aac aac cac gtg cgc acc ctg atc gcg cgc gag gag gtg acc ctg 11382 Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr Leu 885 890 895 ggc ctg atg cac ctg tgg gac ctg ctg gag gcc atc gtg cag aac ccc 11430 Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn Pro 900 905 910 acc agc aag ccg ctg acg gcg cag ctg ttc ctg gtg gtg cag cac agt 11478 Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His Ser 915 920 925 930 cgg gac aac gag gcg ttc agg gag gcg ctg ctg aat atc act gag ccc 11526 Arg Asp Asn Glu Ala Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu Pro 935 940 945 gag ggc cgc tgg ctc ctg gac ctg gtg aac att ctg caa agc atc gtg 11574 Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile Val 950 955 960 gtg cag gag cgc ggg ctg ccg ctg tcc gag aag ctg gcg gcc atc aac 11622 Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile Asn 965 970 975 ttc tcg gtg ctg agt ctg ggc aag tac tac gct agg aag atc tac aag 11670 Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr Lys 980 985 990 acc ccg tac gtg ccc ata gac aag gag gtg aag atc gat ggg ttt 11715 Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe 995 1000 1005 tac atg cgc atg acc ctg aaa gtg ctg acc ctg agc gac gat ctg 11760 Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu 1010 1015 1020 ggg gtg tac cgc aac gac agg atg cac cgc gcg gtg agc gcc agc 11805 Gly Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser 1025 1030 1035 agg cgg cgc gag ctg agc gac cag gag ctg atg cat agt ctg cag 11850 Arg Arg Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln 1040 1045 1050 cgg gcc ctg acc ggg gcc ggg acc gag ggg gag agc tac ttt gac 11895 Arg Ala Leu Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp 1055 1060 1065 atg ggc gcg gac ctg cac tgg cag ccc agc cgc cgg gcc ttg gag 11940 Met Gly Ala Asp Leu His Trp Gln Pro Ser Arg Arg Ala Leu Glu 1070 1075 1080 gcg gcc ggt cct ccc tac gta gaa gag gtg gac gag gac gag gag 11985 Ala Ala Gly Pro Pro Tyr Val Glu Glu Val Asp Glu Asp Glu Glu 1085 1090 1095 ggc gag tac ctg gaa gac tgatggcgcg accgtatttt tgctag atg caa 12035 Gly Glu Tyr Leu Glu Asp Met Gln 1100 1105 caa cag cca cct cct gat ccc gca atg cgg gcg gcg ctg cag agc 12080 Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln Ser 1110 1115 1120 cag ccg tcc ggc att aac tcc tcg gac gat tgg acc cag gcc atg 12125 Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 1125 1130 1135 caa cgc atc atg gcg ctg acg acc cgc aac ccc gaa gcc ttt aga 12170 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg 1140 1145 1150 cag cag ccc cag gcc aac cgg ctc tcg gcc atc ctg gag gcc gtg 12215 Gln Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val 1155 1160 1165 gtg ccc tcg cgc tcc aac ccc acg cac gag aag gtc ctg gcc atc 12260 Val Pro Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile 1170 1175 1180 gtg aac gcg ctg gtg gag aac aag gcc atc cgc ggc gac gag gcc 12305 Val Asn Ala Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala 1185 1190 1195 ggc ctg gtg tac aac gcg ctg ctg gag cgc gtg gct cgc tac aac 12350 Gly Leu Val Tyr Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn 1200 1205 1210 agc acc aac gtg cag acc aac ctg gac cgc atg gtg acc gac gtg 12395 Ser Thr Asn Val Gln Thr Asn Leu Asp Arg Met Val Thr Asp Val 1215 1220 1225 cgc gag gcc gtg gcc cag cgc gag cgg ttc cac cgc gag tcc aac 12440 Arg Glu Ala Val Ala Gln Arg Glu Arg Phe His Arg Glu Ser Asn 1230 1235 1240 ctg gga tcc atg gtg gcg ctg aac gcc ttc ctc agc acc cag ccc 12485 Leu Gly Ser Met Val Ala Leu Asn Ala Phe Leu Ser Thr Gln Pro 1245 1250 1255 gcc aac gtg ccc cgg ggc cag gag gac tac acc aac ttc atc agc 12530 Ala Asn Val Pro Arg Gly Gln Glu Asp Tyr Thr Asn Phe Ile Ser 1260 1265 1270 gcc ctg cgc ctg atg gtg acc gag gtg ccc cag agc gag gtg tac 12575 Ala Leu Arg Leu Met Val Thr Glu Val Pro Gln Ser Glu Val Tyr 1275 1280 1285 cag tcc ggg ccg gac tac ttc ttc cag acc agt cgc cag ggc ttg 12620 Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr Ser Arg Gln Gly Leu 1290 1295 1300 cag acc gtg aac ctg agc cag gcg ttc aag aac ttg cag ggc ctg 12665 Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn Leu Gln Gly Leu 1305 1310 1315 tgg ggc gtg cag gcc ccg gtc ggg gac cgc gcg acg gtg tcg agc 12710 Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr Val Ser Ser 1320 1325 1330 ctg ctg acg ccg aac tcg cgc ctg ctg ctg ttg ctg gtg gcg ccc 12755 Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val Ala Pro 1335 1340 1345 ttc acg gac agc ggc agc atc aac cgc aac tcg tac ctg ggc tac 12800 Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly Tyr 1350 1355 1360 ctg att aac ttg tac cgc gag gcc atc ggc cag gcg cac gtg gac 12845 Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 1365 1370 1375 gag cag acc tac cag gag atc acc cac gtg agc cgc gcc ctg ggc 12890 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly 1380 1385 1390 cag gac gac ccg ggc aat ctg gaa gcc acc ctg aac ttt ttg ctg 12935 Gln Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu 1395 1400 1405 acc aac cgg tcg cag aag atc ccg ccc cag tac gcg ctc agt gcc 12980 Thr Asn Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Ala 1410 1415 1420 gag gag gag cgc atc ctg cga tac gtg cag cag agc gtg ggc ctg 13025 Glu Glu Glu Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu 1425 1430 1435 ttc ctg atg cag gag ggg gcc acc ccc agc gcc gcg ctc gac atg 13070 Phe Leu Met Gln Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met 1440 1445 1450 acc gcg cgc aac atg gag ccc agc atg tac gcc agc aac cgc ccg 13115 Thr Ala Arg Asn Met Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro 1455 1460 1465 ttc atc aat aaa ctg atg gac tac ttg cat cgg gcg gcc gcc atg 13160 Phe Ile Asn Lys Leu Met Asp Tyr Leu His Arg Ala Ala Ala Met 1470 1475 1480 aac tct gac tat ttc acc aac gcc atc ctg aat ccc cac tgg ctc 13205 Asn Ser Asp Tyr Phe Thr Asn Ala Ile Leu Asn Pro His Trp Leu 1485 1490 1495 ccg ccg ccg ggg ttc tac acg ggc gag tac gac atg ccc gac ccc 13250 Pro Pro Pro Gly Phe Tyr Thr Gly Glu Tyr Asp Met Pro Asp Pro 1500 1505 1510 aat gac ggg ttc ctg tgg gac gat gtg gac agc agc gtg ttc tcc 13295 Asn Asp Gly Phe Leu Trp Asp Asp Val Asp Ser Ser Val Phe Ser 1515 1520 1525 ccc cga ccg ggt gct aac gag cgc ccc ttg tgg aag aag gaa ggc 13340 Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu Trp Lys Lys Glu Gly 1530 1535 1540 agc gac cgg cgc ccg tcc tcg gcg ctg tcc ggc cgc gag ggt gct 13385 Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly Arg Glu Gly Ala 1545 1550 1555 gcc gcg gcg gtg ccc gag gcc gcc agt cct ttc cct agc ttg ccc 13430 Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro Ser Leu Pro 1560 1565 1570 ttc tcg ctg aac agt atc cgc agc agc gag ctg ggc agg atc acg 13475 Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg Ile Thr 1575 1580 1585 cgc ccg cgc ttg ctg ggc gag gag gag tac ttg aat gac tcc ttg 13520 Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser Leu 1590 1595 1600 ctg aga ccc gag cgg gag aag aac ttc ccc aat aac ggg ata gag 13565 Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 1605 1610 1615 agc ctg gtg gac aag atg agc cgc tgg aag acg tac gcg cag gag 13610 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu 1620 1625 1630 cac agg gac gat ccc cgg gcg tcg cag ggg gcc gcg agc cgg ggc 13655 His Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Ala Ser Arg Gly 1635 1640 1645 agc gcc gcc cgt aaa cgc cgg tgg cac gac agg cag cgg gga ctg 13700 Ser Ala Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu 1650 1655 1660 atg tgg gac gat gag gac tcc gcc gac gac agc agc gtg ttg gac 13745 Met Trp Asp Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp 1665 1670 1675 ttg ggt ggg agt ggt ggt aac ccg ttc gct cac ctg cgc ccc cgc 13790 Leu Gly Gly Ser Gly Gly Asn Pro Phe Ala His Leu Arg Pro Arg 1680 1685 1690 atc ggg cgc atg atg taagaaaccg aaaataaatg atactcacca aggccatggc 13845 Ile Gly Arg Met Met 1695 gaccagcgtg cgttcgtttc ttctctgttg tatctagt atg atg agg cgt gcg 13898 Met Met Arg Arg Ala 1700 tac ccg gag ggt cct cct ccc tcg tac gag agc gtg atg cag cag 13943 Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser Val Met Gln Gln 1705 1710 1715 gcg atg gcg gcg gcg gcg gcg atg cag ccc ccg ctg gag gct cct 13988 Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu Glu Ala Pro 1720 1725 1730 tac gtg ccc ccg cgg tac ctg gcg cct acg gag ggg cgg aac agc 14033 Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg Asn Ser 1735 1740 1745 att cgt tac tcg gag ctg gca ccc ttg tac gat acc acc cgg ttg 14078 Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg Leu 1750 1755 1760 tac ctg gtg gac aac aag tcg gcg gac atc gcc tcg ctg aac tac 14123 Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 1765 1770 1775 cag aac gac cac agc aac ttc ctg acc acc gtg gtg cag aac aat 14168 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn 1780 1785 1790 gac ttc acc ccc acg gag gcc agc acc cag acc atc aac ttt gac 14213 Asp Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp 1795 1800 1805 gag cgc tcg cgg tgg ggc ggc cag ctg aaa acc atc atg cac acc 14258 Glu Arg Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr 1810 1815 1820 aac atg ccc aac gtg aac gag ttc atg tac agc aac aag ttc aag 14303 Asn Met Pro Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys 1825 1830 1835 gcg cgg gtc atg gtc tcc cgc aag acc ccc aac ggg gtg aca gtg 14348 Ala Arg Val Met Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val 1840 1845 1850 aca gat ggt agt cag gat gag ttg aaa tac gag tgg gtg gag ttt 14393 Thr Asp Gly Ser Gln Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe 1855 1860 1865 gag ctg ccc gaa ggc aac ttc tcg gtg acc atg acc atc gac ctg 14438 Glu Leu Pro Glu Gly Asn Phe Ser Val Thr Met Thr Ile Asp Leu 1870 1875 1880 atg aac aac gcc atc atc gac aat tac ttg gcg gtg ggg cgg cag 14483 Met Asn Asn Ala Ile Ile Asp Asn Tyr Leu Ala Val Gly Arg Gln 1885 1890 1895 aac ggg gtc ctg gag agc gac atc ggc gtg aag ttc gac act agg 14528 Asn Gly Val Leu Glu Ser Asp Ile Gly Val Lys Phe Asp Thr Arg 1900 1905 1910 aac ttc agg ctg ggc tgg gac ccc gtg acc gag ctg gtc atg ccc 14573 Asn Phe Arg Leu Gly Trp Asp Pro Val Thr Glu Leu Val Met Pro 1915 1920 1925 ggg gtg tac acc aac gag gcc ttc cat ccc gat att gtg ctg ctg 14618 Gly Val Tyr Thr Asn Glu Ala Phe His Pro Asp Ile Val Leu Leu 1930 1935 1940 ccc ggc tgc ggg gtg gac ttt acc gag agc cgc ctt agc aac ctg 14663 Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg Leu Ser Asn Leu 1945 1950 1955 ctg ggc att cgc aag agg cag cct ttc cag gag ggt ttc cag atc 14708 Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly Phe Gln Ile 1960 1965 1970 atg tac gag gat ctg gag ggg ggc aac atc ccc gca ctc ctg gat 14753 Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu Leu Asp 1975 1980 1985 gtc gag gcc tac gag aaa agc aag gag gag aat gca gca gcc gag 14798 Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Asn Ala Ala Ala Glu 1990 1995 2000 gcc gtg gct acc gcc gcg acc gcc gag gcc aag gct gtg gta gat 14843 Ala Val Ala Thr Ala Ala Thr Ala Glu Ala Lys Ala Val Val Asp 2005 2010 2015 gca gac gcc aat gtg acc agg ggc gat aca ttc gcc act cag gcg 14888 Ala Asp Ala Asn Val Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala 2020 2025 2030 gag gaa gca gcc gcc cta gcg gtc gcc gat gat agt gaa agt acc 14933 Glu Glu Ala Ala Ala Leu Ala Val Ala Asp Asp Ser Glu Ser Thr 2035 2040 2045 aag aca gtg acc att cag cca gta aaa gtg gat agc aag aac agg 14978 Lys Thr Val Thr Ile Gln Pro Val Lys Val Asp Ser Lys Asn Arg 2050 2055 2060 agt tac aac gtg ctg ccg gac gag aaa aac acc gcc tac cgc agc 15023 Ser Tyr Asn Val Leu Pro Asp Glu Lys Asn Thr Ala Tyr Arg Ser 2065 2070 2075 tgg tac ctg gcc tac aac tat ggc gac ccc gag aag ggc gtg cgc 15068 Trp Tyr Leu Ala Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg 2080 2085 2090 tcc tgg acg ctg ctc acc acc tcg gac gtc acc tgc ggc gtg gag 15113 Ser Trp Thr Leu Leu Thr Thr Ser Asp Val Thr Cys Gly Val Glu 2095 2100 2105 caa gtc tac tgg tcg ctg ccc gac atg atg caa gac ccg gtc acc 15158 Gln Val Tyr Trp Ser Leu Pro Asp Met Met Gln Asp Pro Val Thr 2110 2115 2120 ttc cgc tcc acg cgt caa gtt agc aac tac ccg gtg gtg ggc gcc 15203 Phe Arg Ser Thr Arg Gln Val Ser Asn Tyr Pro Val Val Gly Ala 2125 2130 2135 gag ctc ctg ccc gtc tac tcc aag agc ttc ttc aac gag cag gcc 15248 Glu Leu Leu Pro Val Tyr Ser Lys Ser Phe Phe Asn Glu Gln Ala 2140 2145 2150 gtc tac tcg cag cag ctg cgc gcc ttc acc tcg ctc acg cac gtc 15293 Val Tyr Ser Gln Gln Leu Arg Ala Phe Thr Ser Leu Thr His Val 2155 2160 2165 ttc aac cgc ttc ccc gag aac cag atc ctc gtc cgc ccg ccc gcg 15338 Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu Val Arg Pro Pro Ala 2170 2175 2180 ccc acc att acc acc gtc agt gaa aac gtt cct gct ctc aca gat 15383 Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro Ala Leu Thr Asp 2185 2190 2195 cac ggg acc ctg ccg ctg cgc agc agt atc cgg gga gtc cag cgc 15428 His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly Val Gln Arg 2200 2205 2210 gtg acc gtt act gac gcc aga cgc cgc acc tgc ccc tac gtc tac 15473 Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr Val Tyr 2215 2220 2225 aag gcc ctg ggc ata gtc gcg ccg cgc gtc ctc tcg agc cgc acc 15518 Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg Thr 2230 2235 2240 ttc taaaaa atg tcc att ctc atc tcg ccc agt aat aac acc ggt tgg 15566 Phe Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp 2245 2250 2255 ggc ctg cgc gcg ccc agc aag atg tac gga ggc gct cgc caa cgc 15611 Gly Leu Arg Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg 2260 2265 2270 tcc acg caa cac ccc gtg cgc gtg cgc ggg cac ttc cgc gct ccc 15656 Ser Thr Gln His Pro Val Arg Val Arg Gly His Phe Arg Ala Pro 2275 2280 2285 tgg ggc gcc ctc aag ggc cgc gtg cgg tcg cgc acc acc gtc gac 15701 Trp Gly Ala Leu Lys Gly Arg Val Arg Ser Arg Thr Thr Val Asp 2290 2295 2300 gac gtg atc gac cag gtg gtg gcc gac gcg cgc aac tac acc ccc 15746 Asp Val Ile Asp Gln Val Val Ala Asp Ala Arg Asn Tyr Thr Pro 2305 2310 2315 gcc gcc gcg ccc gtc tcc acc gtg gac gcc gtc atc gac agc gtg 15791 Ala Ala Ala Pro Val Ser Thr Val Asp Ala Val Ile Asp Ser Val 2320 2325 2330 gtg gcc gac gcg cgc cgg tac gcc cgc gcc aag agc cgg cgg cgg 15836 Val Ala Asp Ala Arg Arg Tyr Ala Arg Ala Lys Ser Arg Arg Arg 2335 2340 2345 cgc atc gcc cgg cgg cac cgg agc acc ccc gcc atg cgc gcg gcg 15881 Arg Ile Ala Arg Arg His Arg Ser Thr Pro Ala Met Arg Ala Ala 2350 2355 2360 cga gcc ttg ctg cgc agg gcc agg cgc acg gga cgc agg gcc atg 15926 Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr Gly Arg Arg Ala Met 2365 2370 2375 ctc agg gcg gcc aga cgc gcg gct tca ggc gcc agc gcc ggc agg 15971 Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala Ser Ala Gly Arg 2380 2385 2390 acc cgg aga cgc gcg gcc acg gcg gcg gca gcg gcc atc gcc agc 16016 Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala Ile Ala Ser 2395 2400 2405 atg tcc cgc ccg cgg cga ggg aac gtg tac tgg gtg cgc gac gcc 16061 Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg Asp Ala 2410 2415 2420 gcc acc ggt gtg cgc gtg ccc gtg cgc acc cgc ccc cct cgc act 16106 Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg Thr 2425 2430 2435 tgaagatgtt cacttcgcga tgttgatgtg tcccagcggc gagg atg tcc aag cgc 16162 Met Ser Lys Arg 2440 aaa ttc aag gaa gag atg ctc cag gtc atc gcg cct gag atc tac 16207 Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro Glu Ile Tyr 2445 2450 2455 ggc ccc gcg gtg gtg aag gag gaa aga aag ccc cgc aaa atc aag 16252 Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys Ile Lys 2460 2465 2470 cgg gtc aaa aag gac aaa aag gaa gaa gat gac gat ctg gtg gag 16297 Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Asp Asp Leu Val Glu 2475 2480 2485 ttt gtg cgc gag ttc gcc ccc cgg cgg cgc gtg cag tgg cgc ggg 16342 Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly 2490 2495 2500 cgg aag gtg caa ccg gtg ctg aga ccc ggc acc acc gtg gtc ttc 16387 Arg Lys Val Gln Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe 2505 2510 2515 acg ccc ggc gag cgc tca ggc acc gct tcc aag cgc tcc tac gac 16432 Thr Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp 2520 2525 2530 gag gtg tac ggg gat gat gat att ctg gag cag gcg gcc gag cgc 16477 Glu Val Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg 2535 2540 2545 ctg ggc gag ttt gct tac ggc aag cgc agc cgc tcc gcg ccg aag 16522 Leu Gly Glu Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys 2550 2555 2560 gaa gag gcg gtg tcc atc ccg ctg gac cat ggc aac ccc acg ccg 16567 Glu Glu Ala Val Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro 2565 2570 2575 agc ctc aag ccc gtg acc ctg cag cag gtg ctg ccg agc gcg gcg 16612 Ser Leu Lys Pro Val Thr Leu Gln Gln Val Leu Pro Ser Ala Ala 2580 2585 2590 ccg cgt cgg ggg ttc aag cgc gag ggc gag gat ctg tac ccc acc 16657 Pro Arg Arg Gly Phe Lys Arg Glu Gly Glu Asp Leu Tyr Pro Thr 2595 2600 2605 atg cag ctg atg gtg ccc aag cgc cag aag ctg gaa gac gtg ctg 16702 Met Gln Leu Met Val Pro Lys Arg Gln Lys Leu Glu Asp Val Leu 2610 2615 2620 gag acc atg aag gtg gac ccg gac gtg cag ccc gag gtc aag gtg 16747 Glu Thr Met Lys Val Asp Pro Asp Val Gln Pro Glu Val Lys Val 2625 2630 2635 cgg ccc atc aag cag gtg gcc ccg ggc ctg ggc gtg cag acc gtg 16792 Arg Pro Ile Lys Gln Val Ala Pro Gly Leu Gly Val Gln Thr Val 2640 2645 2650 gac atc aag atc ccc acg gag ccc atg gaa acg cag acc gag ccc 16837 Asp Ile Lys Ile Pro Thr Glu Pro Met Glu Thr Gln Thr Glu Pro 2655 2660 2665 gtg aaa ccc agc acc agc acc atg gag gtg cag acg gat cct tgg 16882 Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln Thr Asp Pro Trp 2670 2675 2680 atg cca gcc gcc ccc acc act cga aga ccc cgg cgc aag tac ggc 16927 Met Pro Ala Ala Pro Thr Thr Arg Arg Pro Arg Arg Lys Tyr Gly 2685 2690 2695 gcg gcc agc ctg ctg atg ccc aac tac gcg ctg cat cct tcc atc 16972 Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu His Pro Ser Ile 2700 2705 2710 atc ccc acg ccg ggc tac cgc ggc acg cgc ttc tac cgc ggt cat 17017 Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly His 2715 2720 2725 aca agc cgc cgc cgc aag acc acc act cgc cgc cgc cgt cgc cgc 17062 Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg 2730 2735 2740 acc gcc gct gca tct acc cct gcc gcc ctg gtg cgg aga gtg tac 17107 Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg Val Tyr 2745 2750 2755 cgc cgc ggc cgc gcg cct ctg acc ctg ccg cgc gcg cgc tac cac 17152 Arg Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His 2760 2765 2770 ccg agc atc gcc att taaaactttc gcctgctttg cagatca atg gcc ctc 17203 Pro Ser Ile Ala Ile Met Ala Leu 2775 aca tgc cgc ctc cgc gtt ccc att acg ggc tac cga gga aga aaa 17248 Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly Arg Lys 2780 2785 2790 ccg cgc cgt aga agg ctg gcg ggg aac ggg atg cgt cgc cac cac 17293 Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His His 2795 2800 2805 cac cgg cgg cgg cgc gcc atc agc aag cgg ttg ggg gga ggc ttc 17338 His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 2810 2815 2820 ctg ccc gcg ctg atc ccc atc atc gcc gcg gcg atc ggg gcg atc 17383 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile 2825 2830 2835 ccc ggc att gct tcc gtg gcg gtg cag gcc tct cag cgc cac tga 17428 Pro Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 2840 2845 2850 gacacacttg gaaaacatct tgtaataaac ca atg gac tct gac gct cct ggt 17481 Met Asp Ser Asp Ala Pro Gly 2855 cct gtg atg tgt ttt cgt aga cag atg gaa gac atc aat ttt tcg 17526 Pro Val Met Cys Phe Arg Arg Gln Met Glu Asp Ile Asn Phe Ser 2860 2865 2870 tcc ctg gct ccg cga cac ggc acg cgg ccg ttc atg ggc acc tgg 17571 Ser Leu Ala Pro Arg His Gly Thr Arg Pro Phe Met Gly Thr Trp 2875 2880 2885 agc gac atc ggc acc agc caa ctg aac ggg ggc gcc ttc aat tgg 17616 Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly Ala Phe Asn Trp 2890 2895 2900 agc agt ctc tgg agc ggg ctt aag aat ttc ggg tcc acg ctt aaa 17661 Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser Thr Leu Lys 2905 2910 2915 acc tat ggc agc aag gcg tgg aac agc acc aca ggg cag gcg ctg 17706 Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln Ala Leu 2920 2925 2930 agg gat aag ctg aaa gag cag aac ttc cag cag aag gtg gtc gat 17751 Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val Asp 2935 2940 2945 ggg ctc gcc tcg ggc atc aac ggg gtg gtg gac ctg gcc aac cag 17796 Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 2950 2955 2960 gcc gtg cag cgg cag atc aac agc cgc ctg gac ccg gtg ccg ccc 17841 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro 2965 2970 2975 gcc ggc tcc gtg gag atg ccg cag gtg gag gag gag ctg cct ccc 17886 Ala Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro 2980 2985 2990 ctg gac aag cgg ggc gag aag cga ccc cgc ccc gac gcg gag gag 17931 Leu Asp Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu 2995 3000 3005 acg ctg ctg acg cac acg gac gag ccg ccc ccg tac gag gag gcg 17976 Thr Leu Leu Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala 3010 3015 3020 gtg aaa ctg ggt ctg ccc acc acg cgg ccc atc gcg ccc ctg gcc 18021 Val Lys Leu Gly Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala 3025 3030 3035 acc gga gtg ctg aaa ccc gaa act aag ccc gcg acc ctg gac ttg 18066 Thr Gly Val Leu Lys Pro Glu Thr Lys Pro Ala Thr Leu Asp Leu 3040 3045 3050 cct cct ccc cag cct tcc cgc ccc tcc aca gtg gct aag ccc ctg 18111 Pro Pro Pro Gln Pro Ser Arg Pro Ser Thr Val Ala Lys Pro Leu 3055 3060 3065 ccg ccg gtg gcc gtg gcc cgc gcg cga ccc ggg ggc acc gcc cgc 18156 Pro Pro Val Ala Val Ala Arg Ala Arg Pro Gly Gly Thr Ala Arg 3070 3075 3080 cct cat gcg aac tgg cag agc act ctg aac agc atc gtg ggt ctg 18201 Pro His Ala Asn Trp Gln Ser Thr Leu Asn Ser Ile Val Gly Leu 3085 3090 3095 gga gtg cag agt gtg aag cgc cgc cgc tgc tat taaacctacc 18244 Gly Val Gln Ser Val Lys Arg Arg Arg Cys Tyr 3100 3105 3110 gtagcgctta acttgcttgt ctgtgtgtgt atgtattatg tcgccgccgc cgctgtccac 18304 cagaaggagg agtgaagagg cgcgtcgccg agttgcaag atg gcc acc cca tcg 18358 Met Ala Thr Pro Ser 3115 atg ctg ccc cag tgg gcg tac atg cac atc gcc gga cag gac gct 18403 Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala Gly Gln Asp Ala 3120 3125 3130 tcg gag tac ctg agt ccg ggt ctg gtg cag ttc gcc cgc gcc aca 18448 Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala Arg Ala Thr 3135 3140 3145 gac acc tac ttc agt ctg ggg aac aag ttt agg aac ccc acg gtg 18493 Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro Thr Val 3150 3155 3160 gcg ccc acg cac gat gtg acc acc gac cgc agc cag cgg ctg acg 18538 Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu Thr 3165 3170 3175 ctg cgc ttc gtg ccc gtg gac cgc gag gac aac acc tac tcg tac 18583 Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 3180 3185 3190 aaa gtg cgc tac acg ctg gcc gtg ggc gac aac cgc gtg ctg gac 18628 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp 3195 3200 3205 atg gcc agc acc tac ttt gac atc cgc ggc gtg ctg gac cgg ggc 18673 Met Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly 3210 3215 3220 cct agc ttc aaa ccc tac tcc ggc acc gcc tac aac agc ctg gct 18718 Pro Ser Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala 3225 3230 3235 ccc aag gga gca ccc aac acc tca cag tgg gta acc aaa gat aat 18763 Pro Lys Gly Ala Pro Asn Thr Ser Gln Trp Val Thr Lys Asp Asn 3240 3245 3250 ggg act gat aaa aca tac agc ttt ggt aat gct cct gtc cga ggt 18808 Gly Thr Asp Lys Thr Tyr Ser Phe Gly Asn Ala Pro Val Arg Gly 3255 3260 3265 ttg gac att aca gaa gag ggt ctc caa att gga act gat gac tct 18853 Leu Asp Ile Thr Glu Glu Gly Leu Gln Ile Gly Thr Asp Asp Ser 3270 3275 3280 tca acc gaa agc aag aaa att ttt gca gac aaa aca tat cag cct 18898 Ser Thr Glu Ser Lys Lys Ile Phe Ala Asp Lys Thr Tyr Gln Pro 3285 3290 3295 gaa cct cag gtt gga gat gag gaa tgg cat gac acc att ggg gct 18943 Glu Pro Gln Val Gly Asp Glu Glu Trp His Asp Thr Ile Gly Ala 3300 3305 3310 gaa gac aaa tat gga ggc aga gct ctt aaa cct gcc acc aac atg 18988 Glu Asp Lys Tyr Gly Gly Arg Ala Leu Lys Pro Ala Thr Asn Met 3315 3320 3325 aaa ccc tgt tat ggt tct ttt gcc aag cca act aat gct aag gga 19033 Lys Pro Cys Tyr Gly Ser Phe Ala Lys Pro Thr Asn Ala Lys Gly 3330 3335 3340 ggt cag gct aaa acc aga acc aaa gac gat gga act acc gag cct 19078 Gly Gln Ala Lys Thr Arg Thr Lys Asp Asp Gly Thr Thr Glu Pro 3345 3350 3355 gat att gat atg gcc ttc ttt gac gat cgc agt cag cag gct agt 19123 Asp Ile Asp Met Ala Phe Phe Asp Asp Arg Ser Gln Gln Ala Ser 3360 3365 3370 ttc agt cca gaa ctt gtt ttg tat act gag aat gtg gat ttg gag 19168 Phe Ser Pro Glu Leu Val Leu Tyr Thr Glu Asn Val Asp Leu Glu 3375 3380 3385 acc cca gat acc cac att att tac aaa ccc ggt act gat gaa acc 19213 Thr Pro Asp Thr His Ile Ile Tyr Lys Pro Gly Thr Asp Glu Thr 3390 3395 3400 agt tct tct ttc aac ttg ggc cag caa tcc atg ccc aac agg ccc 19258 Ser Ser Ser Phe Asn Leu Gly Gln Gln Ser Met Pro Asn Arg Pro 3405 3410 3415 aac tac att ggt ttc aga gac aac ttt att ggt ctc atg tat tac 19303 Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr 3420 3425 3430 aac agc act ggc aat atg ggg gtg ctg gcc ggt cag gct tct cag 19348 Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln 3435 3440 3445 ctg aat gct gtg gtt gac ttg caa gac aga aac acc gag ctg tcc 19393 Leu Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser 3450 3455 3460 tac cag ctc ttg ctt gac tct ctg ggc gac aga acc cgg tat ttc 19438 Tyr Gln Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe 3465 3470 3475 agt atg tgg aac cag gcg gtg gac agc tat gat cct gat gtg cgc 19483 Ser Met Trp Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg 3480 3485 3490 att att gaa aac cat ggt gtg gag gat gaa ttg cca aac tat tgt 19528 Ile Ile Glu Asn His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys 3495 3500 3505 ttc cct ctg aac ggt gtg ggc ttc aca gac aca ttc cag gga att 19573 Phe Pro Leu Asn Gly Val Gly Phe Thr Asp Thr Phe Gln Gly Ile 3510 3515 3520 aag gtt aaa act acc aac aac ggt act gct aat gct aca gag tgg 19618 Lys Val Lys Thr Thr Asn Asn Gly Thr Ala Asn Ala Thr Glu Trp 3525 3530 3535 gag tct gat act tct gtc aat aat gcc aat gag att gcc aag ggt 19663 Glu Ser Asp Thr Ser Val Asn Asn Ala Asn Glu Ile Ala Lys Gly 3540 3545 3550 aat cca ttt gcc atg gaa atc aac att caa gcc aac ctg tgg agg 19708 Asn Pro Phe Ala Met Glu Ile Asn Ile Gln Ala Asn Leu Trp Arg 3555 3560 3565 aac ttc ctc tat gcc aac gtg gcc ctg tac ctg ccc gat tct tac 19753 Asn Phe Leu Tyr Ala Asn Val Ala Leu Tyr Leu Pro Asp Ser Tyr 3570 3575 3580 aag tac acg ccg gcc aac gtc acc ctg ccc acc aac atc aac acc 19798 Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro Thr Asn Ile Asn Thr 3585 3590 3595 tac gat tac atg aac ggc cgg gtg gtg gcg ccc tcg ctg gtg gac 19843 Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro Ser Leu Val Asp 3600 3605 3610 tcc tac atc aac atc ggg gcg cgc tgg tcg ctg gac ccc atg gac 19888 Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp Pro Met Asp 3615 3620 3625 aac gtc aat ccc ttc aac cac cac cgc aac gcg ggg ctg cgc tac 19933 Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu Arg Tyr 3630 3635 3640 cgc tcc atg ctc ctg ggc aac ggg cgc tac gtg ccc ttc cac atc 19978 Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His Ile 3645 3650 3655 cag gtg ccc cag aaa ttt ttc gcc atc aag agc ctc ctg ctc ctg 20023 Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu 3660 3665 3670 ccc ggg tcc tac acc tac gag tgg aac ttc cgc aag gac gtc aac 20068 Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn 3675 3680 3685 atg atc ctg cag agc tcc ctc ggc aac gac ctg cgc acg gac ggg 20113 Met Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly 3690 3695 3700 gcc tcc atc tcc ttc acc agc atc aac ctc tac gcc acc ttc ttc 20158 Ala Ser Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe 3705 3710 3715 ccc atg gcg cac aac acg gcc tcc acg ctc gag gcc atg ctg cgc 20203 Pro Met Ala His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg 3720 3725 3730 aac gac acc aac gac cag tcc ttc aac gac tac ctc tcg gcg gcc 20248 Asn Asp Thr Asn Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala 3735 3740 3745 aac atg ctc tac ccc atc ccg gcc aac gcc acc aac gtg ccc atc 20293 Asn Met Leu Tyr Pro Ile Pro Ala Asn Ala Thr Asn Val Pro Ile 3750 3755 3760 tcc atc ccc tcg cgc aac tgg gcc gcc ttc cgc ggc tgg tcc ttc 20338 Ser Ile Pro Ser Arg Asn Trp Ala Ala Phe Arg Gly Trp Ser Phe 3765 3770 3775 acg cgc ctc aag acc aag gag acg ccc tcg ctg ggc tcc ggg ttc 20383 Thr Arg Leu Lys Thr Lys Glu Thr Pro Ser Leu Gly Ser Gly Phe 3780 3785 3790 gac ccc tac ttc gtc tac tcg ggc tcc atc ccc tac ctc gac ggc 20428 Asp Pro Tyr Phe Val Tyr Ser Gly Ser Ile Pro Tyr Leu Asp Gly 3795 3800 3805 acc ttc tac ctc aac cac acc ttc aag aag gtc tcc atc acc ttc 20473 Thr Phe Tyr Leu Asn His Thr Phe Lys Lys Val Ser Ile Thr Phe 3810 3815 3820 gac tcc tcc gtc agc tgg ccc ggc aac gac cgg ctc ctg acg ccc 20518 Asp Ser Ser Val Ser Trp Pro Gly Asn Asp Arg Leu Leu Thr Pro 3825 3830 3835 aac gag ttc gaa atc aag cgc acc gtc gac ggc gag gga tac aac 20563 Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly Glu Gly Tyr Asn 3840 3845 3850 gtg gcc cag tgc aac atg acc aag gac tgg ttc ctg gtc cag atg 20608 Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu Val Gln Met 3855 3860 3865 ctg gcc cac tac aac atc ggc tac cag ggc ttc tac gtg ccc gag 20653 Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val Pro Glu 3870 3875 3880 ggc tac aag gac cgc atg tac tcc ttc ttc cgc aac ttc cag ccc 20698 Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln Pro 3885 3890 3895 atg agc cgc cag gtg gtg gac gag gtc aac tac aag gac tac cag 20743 Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln 3900 3905 3910 gcc gtc acc ctg gcc tac cag cac aac aac tcg ggc ttc gtc ggc 20788 Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly 3915 3920 3925 tac ctc gcg ccc acc atg cgc cag ggc cag ccc tac ccc gcc aac 20833 Tyr Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn 3930 3935 3940 tac ccc tat ccg ctc atc ggc aag agc gcc gtc acc agc gtc acc 20878 Tyr Pro Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr 3945 3950 3955 cag aaa aag ttc ctc tgc gac agg gtc atg tgg cgc atc ccc ttc 20923 Gln Lys Lys Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe 3960 3965 3970 tcc agc aac ttc atg tcc atg ggc gcg ctc acc gac ctc ggc cag 20968 Ser Ser Asn Phe Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln 3975 3980 3985 aac atg ctc tat gcc aac tcc gcc cac gcg cta gac atg aat ttc 21013 Asn Met Leu Tyr Ala Asn Ser Ala His Ala Leu Asp Met Asn Phe 3990 3995 4000 gaa gtc gac ccc atg gat gag tcc acc ctt ctc tat gtt gtc ttc 21058 Glu Val Asp Pro Met Asp Glu Ser Thr Leu Leu Tyr Val Val Phe 4005 4010 4015 gaa gtc ttc gac gtc gtc cga gtg cac cag ccc cac cgc ggc gtc 21103 Glu Val Phe Asp Val Val Arg Val His Gln Pro His Arg Gly Val 4020 4025 4030 atc gag gcc gtc tac ctg cgc acc ccc ttc tcg gcc ggt aac gcc 21148 Ile Glu Ala Val Tyr Leu Arg Thr Pro Phe Ser Ala Gly Asn Ala 4035 4040 4045 acc acc taagctcttg cttcttgcaa g atg gct gag ccc acg ggc tcc ggc 21199 Thr Thr Met Ala Glu Pro Thr Gly Ser Gly 4050 4055 gag cag gag ctc agg gcc atc atc cgc gac ctg ggc tgc ggg ccc 21244 Glu Gln Glu Leu Arg Ala Ile Ile Arg Asp Leu Gly Cys Gly Pro 4060 4065 4070 tac ttc ctg ggc acc ttc gat aag cgc ttc ccg gga ttc atg gcc 21289 Tyr Phe Leu Gly Thr Phe Asp Lys Arg Phe Pro Gly Phe Met Ala 4075 4080 4085 ccg cac aag ctg gcc tgc gcc atc gtc aac acg gcc ggc cgc gag 21334 Pro His Lys Leu Ala Cys Ala Ile Val Asn Thr Ala Gly Arg Glu 4090 4095 4100 acc ggg ggc gag cac tgg ctg gcc ttc gcc tgg aac ccg cgc tcg 21379 Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp Asn Pro Arg Ser 4105 4110 4115 aac acc tgc tac ctc ttc gac ccc ttc ggg ttc tcg gac gag cga 21424 Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser Asp Glu Arg 4120 4125 4130 ctc aag cag atc tac cag ttc gag tac gaa ggc ctg ctg cgc cgc 21469 Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu Arg Arg 4135 4140 4145 agc gcc ctg gcc acc gag gac cgc tgc gtc acc ctg gaa aag tcc 21514 Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys Ser 4150 4155 4160 acc cag acc gtg cag ggt ccg cgc tcg gcc gcc tgc ggg ctc ttc 21559 Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 4165 4170 4175 tgc tgc atg ttc ctg cac gcc ttc gtg cac tgg ccc gac cgc ccc 21604 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro 4180 4185 4190 atg gac aag aac ccc acc atg aac ttg ctg acg ggg gtg ccc aac 21649 Met Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn 4195 4200 4205 ggc atg ctc cag tcg ccc cag gtg gaa ccc acc ctg cgc cgc aac 21694 Gly Met Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn 4210 4215 4220 cag gag gcg ctc tac cgc ttc ctc aac tcc cac tcc gcc tac ttt 21739 Gln Glu Ala Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe 4225 4230 4235 cgc tcc cac cgc gcg cgc atc gag aag gcc acc gcc ttc gac cgc 21784 Arg Ser His Arg Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg 4240 4245 4250 atg aac aat caa gac atg taacactgtg tgtgtatgtt aaaatatctt 21832 Met Asn Asn Gln Asp Met 4255 ttaataaaca gcactttcat gttacacatg catctgagat gattttattt tagaaatcga 21892 aagggttctg ccgggtctcg gcatggcccg cgggcaggga cacgttgcgg aactggtact 21952 tggccagcca cttgaactcg gggatcagca gtttcggcag cggggtgtcg ggaaaggagt 22012 cggtccacag cttccgcgtc agttgcaggg cgcccagcag gtcgggcgcg gagatcttga 22072 aatcgcagtt gggacccgcg ttctgcgcgc gagagttgcg gtacacgggg ttgcagcact 22132 ggaacaccat cagggccggg tgcttcacgc tcgccagcac cgtcgcgtcg gtgatgctct 22192 ccacgtcgag gtcctcggcg ttggccatcc cgaagggggt catcttgcag gtctgccttc 22252 ccatagtggg cacgcagccg ggcttgtggt tgcaatcgca gtgcaggggg atcagcatca 22312 tctgggcctg gtcggcgttc atccccgggt acatggcctt catgaaagcc tccaattgcc 22372 taaaagcctg ctgggccttg gctccctcgg tgaagaagac cccgcaggac ttgctagaga 22432 actggttggt ggcgcacccg gcgtcgtgca cgcagcagcg cgcgtcgttg ttggccagct 22492 gcaccacgct gcgcccccag cggttctggg tgatcttggc ccggtcgggg ttctccttca 22552 gcgcgcgctg tccgttctcg ctcgccacat ccatctcgat catgtgctcc ttctggatca 22612 tggtggtacc atgcaggcac cgcagcttgc cctcggtctc ggtgcacccg tgcagccaca 22672 gcgcgcaccc ggtgcactcc cagttcttgt gggcgatctg ggaatgcgcg tgcacgaagc 22732 cctgcaggaa gcggcccatc atggtggtta gggtcttgtt gctagtgaag gtcagcggga 22792 tgccgcggtg ctcctcattg atgtacaggt ggcagatgcg gcggtacacc tcgccctgct 22852 cgggcatcag ttggaagttg gctttcaggt cggtctccac gcggtagcgg tccatcagca 22912 tagtcatgat ttccatgccc ttctcccagg ccgagacgat gggtaggctc atggggttct 22972 tcaccatcat cttagcacta gcagccgcgg ccagggggtc gctctcgttc agggtctcaa 23032 agctccgctt gccgtccttc tcggtgatcc gcacgggggg gtagctgaag cccacggccg 23092 ccagctcctc ctcggcctgt ctttcgtcct cgctgtcctg gctgacgtcc tgcaggacca 23152 catgcttggt cttgcggggt ttcttcttgg gcggcagcgg tggcggagat gttggagatg 23212 gtgaggggga gcgcgagttc tcgctcacca ctactatctc ttcctcttct tggtccgagg 23272 ccacgcggcg gtaggtatgt ctcttcgggg gcagaggcgg aggcgacggg ctctcgccgc 23332 cgcgacttgg cggatggctg gcagagcccc ttccgcgttc gggggtgcgc tcccggcggc 23392 gctctgactg acttcctccg cggccggcca ttgtgttctc ctagggaaca acaagc atg 23451 Met gag act cag cca tcg cca acc tcg cca tct gcc ccc acc acc gcc 23496 Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 4260 4265 4270 gac gag aag cag cag cag cag aat gaa agc tta acc gcc ccg ccg 23541 Asp Glu Lys Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro 4275 4280 4285 ccc agc ccc gcc tcc gac gcg gcc gcg gtc cca gac atg caa gag 23586 Pro Ser Pro Ala Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu 4290 4295 4300 atg gag gaa tcc atc gag att gac ctg ggc tat gtg acg ccc gcg 23631 Met Glu Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala 4305 4310 4315 gag cac gag gag gag ctg gca gtg cgc ttt caa tcg tca agc cag 23676 Glu His Glu Glu Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln 4320 4325 4330 gaa gat aaa gaa cag cca gag cag gaa gca gag aac gag cag agt 23721 Glu Asp Lys Glu Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser 4335 4340 4345 cag act ggg ctc gag cat ggc gac tac ctc cac ctg agc ggg gag 23766 Gln Thr Gly Leu Glu His Gly Asp Tyr Leu His Leu Ser Gly Glu 4350 4355 4360 gag gac gcg ctc atc aag cat ctg gcc cgg cag gcc acc atc gtc 23811 Glu Asp Ala Leu Ile Lys His Leu Ala Arg Gln Ala Thr Ile Val 4365 4370 4375 aag gat gcg ctg ctc gac cgc acc gag gtg ccc ctc agc gtg gag 23856 Lys Asp Ala Leu Leu Asp Arg Thr Glu Val Pro Leu Ser Val Glu 4380 4385 4390 gag ctc agc cgc gcc tac gag ctc aac ctc ttc tcg ccg cgc gtg 23901 Glu Leu Ser Arg Ala Tyr Glu Leu Asn Leu Phe Ser Pro Arg Val 4395 4400 4405 ccc ccc aag cgc cag ccc aac ggc acc tgc gag ccc aac ccg cgc 23946 Pro Pro Lys Arg Gln Pro Asn Gly Thr Cys Glu Pro Asn Pro Arg 4410 4415 4420 ctc aac ttc tac ccg gtc ttc gcg gtg ccc gag gcc ctg gcc acc 23991 Leu Asn Phe Tyr Pro Val Phe Ala Val Pro Glu Ala Leu Ala Thr 4425 4430 4435 tac cac atc ttt ttc aag aac caa aag atc ccc gtc tcc tgc cgc 24036 Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro Val Ser Cys Arg 4440 4445 4450 gcc aac cgc acc cgc gcc gac gcc ctt ttc aac ctg ggc ccc ggc 24081 Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu Gly Pro Gly 4455 4460 4465 gcc cgc cta cct gat atc gcc tcc ttg gaa gag gtt ccc aag atc 24126 Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro Lys Ile 4470 4475 4480 ttc gag ggt ctg ggc agc gac gag act cgg gcc gcg aac gct ctg 24171 Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala Leu 4485 4490 4495 caa gga aat gaa gag cat gag cac cac agc gcc ctg gtc gag ttg 24216 Gln Gly Asn Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 4500 4505 4510 gaa ggc gac aac gcg cgg ctg gcg gtg ctc aaa cgc acg gtc gag 24261 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu 4515 4520 4525 ctg acc cat ttc gcc tac ccg gct ctg aac ctg ccc ccc aaa gtc 24306 Leu Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val 4530 4535 4540 atg agc gcg gtc atg gac cag gtg ctc atc aag cgc gcg tcg ccc 24351 Met Ser Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro 4545 4550 4555 atc tcc gag gac gag ggc atg caa gac tcc gag gag ggc aag ccc 24396 Ile Ser Glu Asp Glu Gly Met Gln Asp Ser Glu Glu Gly Lys Pro 4560 4565 4570 gtg gtc agt gac gag cag ctg gcc cgg tgg ctg ggt cct aat gct 24441 Val Val Ser Asp Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala 4575 4580 4585 acc cct cag agt ttg gaa gag cgg cgc aag ctt atg atg gcc gtg 24486 Thr Pro Gln Ser Leu Glu Glu Arg Arg Lys Leu Met Met Ala Val 4590 4595 4600 gtc ctg gtg acc gtg gag ctg gag tgc ctg cgc cgc ttc ttc gcc 24531 Val Leu Val Thr Val Glu Leu Glu Cys Leu Arg Arg Phe Phe Ala 4605 4610 4615 gac gcg gag acc ctg cgc aag gtc gag gag aac ctg cac tac ctc 24576 Asp Ala Glu Thr Leu Arg Lys Val Glu Glu Asn Leu His Tyr Leu 4620 4625 4630 ttc agg cac ggg ttc gtg cgc cag gcc tgc aag atc tcc aat gtg 24621 Phe Arg His Gly Phe Val Arg Gln Ala Cys Lys Ile Ser Asn Val 4635 4640 4645 gag ctg acc aac ctg gtc tcc tac atg ggc atc ttg cac gag aac 24666 Glu Leu Thr Asn Leu Val Ser Tyr Met Gly Ile Leu His Glu Asn 4650 4655 4660 cgc ctg ggg cag aac gtg ctg cac acc acc ctg cgc ggg gag gcc 24711 Arg Leu Gly Gln Asn Val Leu His Thr Thr Leu Arg Gly Glu Ala 4665 4670 4675 cgc cgc gac tac atc cgc gac tgc gtc tac ctg tac ctc tgc cac 24756 Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu Tyr Leu Cys His 4680 4685 4690 acc tgg cag acg ggc atg ggc gtg tgg cag cag tgc ctg gag gag 24801 Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys Leu Glu Glu 4695 4700 4705 cag aac ctg aaa gag cta tgc aag ctc ctg cag aag aac ctc aag 24846 Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn Leu Lys 4710 4715 4720 ggt ctg tgg acc ggg ttc gac gag cgg acc acc gcc tcg gac ctg 24891 Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp Leu 4725 4730 4735 gcc gac ctc atc ttc ccc gag cgc ctc agg ctg acg ctg cgc aac 24936 Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn 4740 4745 4750 ggc ctg ccc gac ttt atg agc caa agc atg ttg caa aac ttt cgc 24981 Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg 4755 4760 4765 tct ttc atc ctc gaa cgc tcc gga atc ctg ccc gcc acc tgc tcc 25026 Ser Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser 4770 4775 4780 gcg ctg ccc tcg gac ttc gtg ccg ctg acc ttc cgc gag tgc ccc 25071 Ala Leu Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro 4785 4790 4795 ccg ccg ctg tgg agc cac tgc tac ctg ctg cgt ctg gcc aac tac 25116 Pro Pro Leu Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr 4800 4805 4810 ctg gcc tac cac tcg gac gtg atc gag gac gtc agc ggc gag gcc 25161 Leu Ala Tyr His Ser Asp Val Ile Glu Asp Val Ser Gly Glu Ala 4815 4820 4825 ctg ctc gag tgc cac tgc cgc tgc aac ctc tgc acg ccg cac cgc 25206 Leu Leu Glu Cys His Cys Arg Cys Asn Leu Cys Thr Pro His Arg 4830 4835 4840 tcc ctg gcc tgc aac ccc cag ctg ctg agc gag acc cag atc atc 25251 Ser Leu Ala Cys Asn Pro Gln Leu Leu Ser Glu Thr Gln Ile Ile 4845 4850 4855 ggc acc ttc gag ttg caa ggg ccc agc gag ggc gag ggt tca gcc 25296 Gly Thr Phe Glu Leu Gln Gly Pro Ser Glu Gly Glu Gly Ser Ala 4860 4865 4870 gcc aag ggg ggt ctg aaa ctc acc ccg ggg ctg tgg acc tcg gcc 25341 Ala Lys Gly Gly Leu Lys Leu Thr Pro Gly Leu Trp Thr Ser Ala 4875 4880 4885 tac ttg cgc aag ttc gtg ccc gag gac tac cat ccc ttc gag atc 25386 Tyr Leu Arg Lys Phe Val Pro Glu Asp Tyr His Pro Phe Glu Ile 4890 4895 4900 agg ttc tac gag gac caa tcc cag ccg ccc aag gcc gag ctg tcg 25431 Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro Lys Ala Glu Leu Ser 4905 4910 4915 gcc tgc gtc atc acc cag ggg gcg atc ctg gcc caa ttg caa gcc 25476 Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala Gln Leu Gln Ala 4920 4925 4930 atc cag aaa tcc cgc caa gaa ttc ttg ctg aaa aag ggc cgc ggg 25521 Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys Gly Arg Gly 4935 4940 4945 gtc tac ctc gac ccc cag acc ggt gag gag ctc aac ccc ggc ttc 25566 Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro Gly Phe 4950 4955 4960 ccc cag gat gcc ccg agg aaa caa gaa gct gaa agt gga gct gcc 25611 Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala Ala 4965 4970 4975 gcc cgt gga gga ttt gga gga aga ctg gga gaa cag cag tca ggc 25656 Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 4980 4985 4990 aga gga gat gga gga aga ctg gga cag cac tca ggc aga gga gga 25701 Arg Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly 4995 5000 5005 cag cct gca aga cag tct gga gga aga cga gga gga ggc aga gga 25746 Gln Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly 5010 5015 5020 gga ggt gga aga agc agc cgc cgc cag acc gtc gtc ctc ggc ggg 25791 Gly Gly Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly 5025 5030 5035 gga gaa agc aag cag cac gga tac cat ctc cgc tcc ggg tcg ggg 25836 Gly Glu Ser Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly 5040 5045 5050 tcc cgc tcg gcc cca cag tagatgggac gagaccgggc gattcccgaa 25884 Ser Arg Ser Ala Pro Gln 5055 ccccaccacc cagaccggta agaaggagcg gcagggatac aagtcctggc gggggcacaa 25944 aaacgccatc gtctcctgct tgcaggcctg cgggggcaac atctccttca cccggcgcta 26004 cctgctcttc caccgcgggg tgaacttccc ccgcaacatc ttgcattact accgtcacct 26064 ccacagcccc tactacttcc aagaagaggc agcagcggca gaaaaagacc agcagaaaac 26124 cagcagctag aaaatccaca gcggcggcag gtggactgag gatcgcggcg aacgagccgg 26184 cgcagacccg ggagctgagg aaccggatct ttcccaccct ctatgccatc ttccagcaga 26244 gtcgggggca ggagcaggaa ctgaaagtca agaaccgttc tctgcgctcg ctcacccgca 26304 gttgtctgta tcacaagagc gaagaccaac ttcagcgcac tctcgaggac gccgaggctc 26364 tcttcaacaa gtactgcgcg ctcactctta aagagtagcc cgcgcccgcc cagtcgcaga 26424 aaaaggcggg aattacgtca cctgtgccct tcgccctagc cgcctccacc catcatc 26481 atg agc aaa gag att ccc acg cct tac atg tgg agc tac cag ccc 26526 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro 5060 5065 5070 cag atg ggc ctg gcc gcc ggc gcc gcc cag gac tac tcc acc cgc 26571 Gln Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg 5075 5080 5085 atg aat tgg ctc agc gcc ggg ccc gcg atg atc tca cgg gtg aat 26616 Met Asn Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn 5090 5095 5100 gac atc cgc gcc cac cga aac cag ata ctc cta gaa cag tca gcg 26661 Asp Ile Arg Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala 5105 5110 5115 ctc acc gcc acg ccc cgc aat cac ctc aat ccg cgt aat tgg ccc 26706 Leu Thr Ala Thr Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro 5120 5125 5130 gcc gcc ctg gtg tac cag gaa att ccc cag ccc acg acc gta cta 26751 Ala Ala Leu Val Tyr Gln Glu Ile Pro Gln Pro Thr Thr Val Leu 5135 5140 5145 ctt ccg cga gac gcc cag gcc gaa gtc cag ctg act aac tca ggt 26796 Leu Pro Arg Asp Ala Gln Ala Glu Val Gln Leu Thr Asn Ser Gly 5150 5155 5160 gtc cag ctg gcg ggc ggc gcc acc ctg tgt cgt cac cgc ccc gct 26841 Val Gln Leu Ala Gly Gly Ala Thr Leu Cys Arg His Arg Pro Ala 5165 5170 5175 cag ggt ata aag cgg ctg gtg atc cgg ggc aga ggc aca cag ctc 26886 Gln Gly Ile Lys Arg Leu Val Ile Arg Gly Arg Gly Thr Gln Leu 5180 5185 5190 aac gac gag gtg gtg agc tct tcg ctg ggt ctg cga cct gac gga 26931 Asn Asp Glu Val Val Ser Ser Ser Leu Gly Leu Arg Pro Asp Gly 5195 5200 5205 gtc ttc caa ctc gcc gga tcg ggg aga tct tcc ttc acg cct cgt 26976 Val Phe Gln Leu Ala Gly Ser Gly Arg Ser Ser Phe Thr Pro Arg 5210 5215 5220 cag gcg gtc ctg act ttg gaa agt tcg tcc tcg cag ccc cgc tcg 27021 Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser Gln Pro Arg Ser 5225 5230 5235 ggc ggc atc ggc act ctc cag ttc gtg gag gag ttc act ccc tcg 27066 Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe Thr Pro Ser 5240 5245 5250 gtc tac ttc aac ccc ttc tcc ggc tcc ccc ggc cac tac ccg gac 27111 Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr Pro Asp 5255 5260 5265 gag ttc atc ccg aac ttt gac gcc atc agc gag tcg gtg gac ggc 27156 Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp Gly 5270 5275 5280 tac gat tga atg tcc cat ggt ggc gcg gct gac cta gct cgg ctt 27201 Tyr Asp Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu 5285 5290 5295 cga cac ctt gac cac tgc cgc cgc ttt cgc tgc ttc gca cgg gac 27246 Arg His Leu Asp His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp 5300 5305 5310 ctc gcc gag ttc acc tac ttc gag ctg ccc gag gag cat cct cag 27291 Leu Ala Glu Phe Thr Tyr Phe Glu Leu Pro Glu Glu His Pro Gln 5315 5320 5325 ggc ccg gcc cac gga gtg cgg atc gtc gtc gaa ggg ggc cta gac 27336 Gly Pro Ala His Gly Val Arg Ile Val Val Glu Gly Gly Leu Asp 5330 5335 5340 tcc cac ctg ctt cgg atc ttc agc cag cgc ccg atc ctg gtc gag 27381 Ser His Leu Leu Arg Ile Phe Ser Gln Arg Pro Ile Leu Val Glu 5345 5350 5355 cgc caa cag ggc aac acc ctc ctg acc ctc tac tgc atc tgc gac 27426 Arg Gln Gln Gly Asn Thr Leu Leu Thr Leu Tyr Cys Ile Cys Asp 5360 5365 5370 cac ccc ggc ctg cat gaa agt ctt tgt tgt ctg ctg tgt act gag 27471 His Pro Gly Leu His Glu Ser Leu Cys Cys Leu Leu Cys Thr Glu 5375 5380 5385 tat aat aaa agc tgagatcagc gactactccg gactcaactg tggtgtttct 27523 Tyr Asn Lys Ser 5390 gcatccatca atcggtcact gaccttcacc gggaacgaga ccgagctcca gctccagtgt 27583 aagccccaca agaagtacct cacctggctg taccagggct ccccgatcgc cgttgttaac 27643 cactgcgacg acgacggagt cctgctgaac ggccccgcca accttacttt ttccacccgc 27703 agaagcaagc tcgagctctt ccaacccttc ctccccggga cctatcagtg catctcggga 27763 ccctgccatc acaccttcca cctgatcccg aataccacct cttccccagc gccgctcccc 27823 actaacaacc aaactaacca ccaccaacgc taccgacgcg acctcgttga atctaatacc 27883 acccacaccg gaggtgagct ccgaggtcct gaatcctctg ggatttatta cggcccctgg 27943 gaggtggtgg ggttaatagc tttaggctta gtagcgggtg ggcttttggc tctctgctac 28003 ctatacctcc cttgcttttc ctacttagtg gtgctttgtt gctggtttaa gaa atg 28059 Met ggg aag atc acc cta gtg tgc ggt gtg ctg gtg acg gtg gtg ctt 28104 Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 5395 5400 5405 tcg att ctg gga ggg gga agc gcg gct gta gtg acg gag aag aag 28149 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys 5410 5415 5420 gcc gat ccc tgc ttg act ttc aac ccc gat aaa tgc cgg ctg agt 28194 Ala Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser 5425 5430 5435 ttt cag ccc gat ggc aat cgg tgc gcg gtg ttg atc aag tgc gga 28239 Phe Gln Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly 5440 5445 5450 tgg gaa tgc gag agt gtg gcg att cag tat aaa aac aag acg cgg 28284 Trp Glu Cys Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg 5455 5460 5465 aac aat act ctc gcg tcc aca tgg cag ccc ggg gac ccc gag tgg 28329 Asn Asn Thr Leu Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp 5470 5475 5480 tac acc gtc tct gtc cct ggt gct gac ggc tcc ctc cgc acg gtg 28374 Tyr Thr Val Ser Val Pro Gly Ala Asp Gly Ser Leu Arg Thr Val 5485 5490 5495 aac aac act ttc att ttt gag cac atg tgc gat acc gcc atg ttc 28419 Asn Asn Thr Phe Ile Phe Glu His Met Cys Asp Thr Ala Met Phe 5500 5505 5510 atg agc aag cag tac ggt atg tgg ccc cca cga aaa gag aat atc 28464 Met Ser Lys Gln Tyr Gly Met Trp Pro Pro Arg Lys Glu Asn Ile 5515 5520 5525 gtg gtc ttc tcc atc gct tac agc gcg tgc acg gtg cta atc acc 28509 Val Val Phe Ser Ile Ala Tyr Ser Ala Cys Thr Val Leu Ile Thr 5530 5535 5540 gcg atc gtg tgc ctg agc att cac atg ctc atc gct att cgc ccc 28554 Ala Ile Val Cys Leu Ser Ile His Met Leu Ile Ala Ile Arg Pro 5545 5550 5555 aga aat aat gcc gag aaa gag aaa cag cca taacacactt ttttcacaca 28604 Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 5560 5565 cctttttcag acc atg gcc tct gtt aca atc ctt att tat ttt ttg ggc 28653 Met Ala Ser Val Thr Ile Leu Ile Tyr Phe Leu Gly 5570 5575 ctt gtg ggc act atc agc agt ttc gac cat aaa aac gta act gct 28698 Leu Val Gly Thr Ile Ser Ser Phe Asp His Lys Asn Val Thr Ala 5580 5585 5590 tat gtt ggt tct aac tgt gta cta tct ggg tac cag tca cat cag 28743 Tyr Val Gly Ser Asn Cys Val Leu Ser Gly Tyr Gln Ser His Gln 5595 5600 5605 cgg gtt tca tgg tac tgg ttt gat aaa aag aac aca gct tat aca 28788 Arg Val Ser Trp Tyr Trp Phe Asp Lys Lys Asn Thr Ala Tyr Thr 5610 5615 5620 ctc tgc aaa ggc tat cag cag ccc aca cat cgc agt ggt ctt tat 28833 Leu Cys Lys Gly Tyr Gln Gln Pro Thr His Arg Ser Gly Leu Tyr 5625 5630 5635 tac agc tgc acc aat aat aat atc aca cta ctt caa gta acc aac 28878 Tyr Ser Cys Thr Asn Asn Asn Ile Thr Leu Leu Gln Val Thr Asn 5640 5645 5650 caa tat tct ggg acc tac tat gga acc aat ttt aac aca aaa cag 28923 Gln Tyr Ser Gly Thr Tyr Tyr Gly Thr Asn Phe Asn Thr Lys Gln 5655 5660 5665 gac act tac tat agt gtc aga gta ttg gat cca act act ccc aga 28968 Asp Thr Tyr Tyr Ser Val Arg Val Leu Asp Pro Thr Thr Pro Arg 5670 5675 5680 act act act aaa cat acc aca act aag aag ccc act aca cct aaa 29013 Thr Thr Thr Lys His Thr Thr Thr Lys Lys Pro Thr Thr Pro Lys 5685 5690 5695 aag cct acc acg ccc aaa acc act aag aca aca act gct aag cag 29058 Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr Ala Lys Gln 5700 5705 5710 acc act acc aca gag cca acc aca acc agc acc aca ctt gct ata 29103 Thr Thr Thr Thr Glu Pro Thr Thr Thr Ser Thr Thr Leu Ala Ile 5715 5720 5725 act aca cac act gag ctg acc tca cag gca act act gaa aat ggt 29148 Thr Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn Gly 5730 5735 5740 ttt gcc cta ttg caa aag ggg gag aac agt agc agc agt cct ctg 29193 Phe Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro Leu 5745 5750 5755 cct act acc ccc agt gag gaa ata ccc aag tcc atg gtt ggc att 29238 Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile 5760 5765 5770 atc gct gct gta gtg gtg tgt atg gtg att atc atc ttg tgc atg 29283 Ile Ala Ala Val Val Val Cys Met Val Ile Ile Ile Leu Cys Met 5775 5780 5785 atg tac tat gcc tgc tac tac aga aaa cac agg cta aac aat aag 29328 Met Tyr Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys 5790 5795 5800 ctg gac ccc cta ctg aat gtt gat ttt taatttttta gaacc atg aag 29376 Leu Asp Pro Leu Leu Asn Val Asp Phe Met Lys 5805 5810 5815 atc cta agc ctt ttt gtt ttt tct atc att acc tct gct att tgt 29421 Ile Leu Ser Leu Phe Val Phe Ser Ile Ile Thr Ser Ala Ile Cys 5820 5825 5830 aaa tca gtg gat aag gac gtt act gtc acc act ggc tct aat tat 29466 Lys Ser Val Asp Lys Asp Val Thr Val Thr Thr Gly Ser Asn Tyr 5835 5840 5845 aca cta aaa ggg cct tcc tca ggt atg ctt tcg tgg tat tgt tat 29511 Thr Leu Lys Gly Pro Ser Ser Gly Met Leu Ser Trp Tyr Cys Tyr 5850 5855 5860 ttt gga aat gat gat aaa cag aca gag ctt tgt aat ttc cag aac 29556 Phe Gly Asn Asp Asp Lys Gln Thr Glu Leu Cys Asn Phe Gln Asn 5865 5870 5875 gga aaa acc aaa aat tct aaa ata gat aac tat caa tgc cat ggt 29601 Gly Lys Thr Lys Asn Ser Lys Ile Asp Asn Tyr Gln Cys His Gly 5880 5885 5890 act gat tta gta ctg atg aat atc acg aaa gca tat gct ggc agt 29646 Thr Asp Leu Val Leu Met Asn Ile Thr Lys Ala Tyr Ala Gly Ser 5895 5900 5905 tat tcc tgt cct gga caa aac acc gaa gaa atg att ttt tac aaa 29691 Tyr Ser Cys Pro Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys 5910 5915 5920 ttg att gtg gtt gat ccc act aca cct cca ccc acc aca act acc 29736 Leu Ile Val Val Asp Pro Thr Thr Pro Pro Pro Thr Thr Thr Thr 5925 5930 5935 aat gca cct acc aca gac aca cag gaa acc act cca gag gca gta 29781 Asn Ala Pro Thr Thr Asp Thr Gln Glu Thr Thr Pro Glu Ala Val 5940 5945 5950 gca gag tta gca aag cag att cat gaa gat tcc ttt gtt gct aat 29826 Ala Glu Leu Ala Lys Gln Ile His Glu Asp Ser Phe Val Ala Asn 5955 5960 5965 act ccc aca cac ccc gga ccg caa tgt cca ggg tta gta gtc agc 29871 Thr Pro Thr His Pro Gly Pro Gln Cys Pro Gly Leu Val Val Ser 5970 5975 5980 ggc att gtc ggt gtg ctt tgc ggg tta gca gtt ata atc atc tgc 29916 Gly Ile Val Gly Val Leu Cys Gly Leu Ala Val Ile Ile Ile Cys 5985 5990 5995 atg ttc att ttt gct tgc tgc tac aga agg ctt cac cga caa aaa 29961 Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg Leu His Arg Gln Lys 6000 6005 6010 tca gac cca ctg ctg aac ctc tat gtt taatttttga ttttccagag cc 30010 Ser Asp Pro Leu Leu Asn Leu Tyr Val 6015 atg aag gca ctt agc act tta gta ttt ttg tcc ttg att ggc att 30055 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile 6020 6025 6030 gtt ttc agt gct ggg ttt ttg aaa aat ctt acc att att gaa ggc 30100 Val Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly 6035 6040 6045 gat aat gca aca ctg gta gga atc agt ggt cag aat gtt agt tgg 30145 Asp Asn Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp 6050 6055 6060 cta aaa tat cat cta gat ggg tgg aaa cct att tgc acc tgg aat 30190 Leu Lys Tyr His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn 6065 6070 6075 gtc agt gtg tac aca tgt cat ggt gtt aac ctc acc att acc aat 30235 Val Ser Val Tyr Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn 6080 6085 6090 gcc acc caa gat cag aat ggc agg ttt aag ggt cag agt ttc act 30280 Ala Thr Gln Asp Gln Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr 6095 6100 6105 agc aac aat ggc tat gaa acc cat aac atg ttc atc tat gat gtc 30325 Ser Asn Asn Gly Tyr Glu Thr His Asn Met Phe Ile Tyr Asp Val 6110 6115 6120 act gtc ata tca aat aag act aca cct acc acc caa aca ccc act 30370 Thr Val Ile Ser Asn Lys Thr Thr Pro Thr Thr Gln Thr Pro Thr 6125 6130 6135 aca cat agc tca act cat gcc atg cag acc act cag acc acc act 30415 Thr His Ser Ser Thr His Ala Met Gln Thr Thr Gln Thr Thr Thr 6140 6145 6150 tac act aca tcc att cag ccc acc acc act aca gca gag gta acc 30460 Tyr Thr Thr Ser Ile Gln Pro Thr Thr Thr Thr Ala Glu Val Thr 6155 6160 6165 agc aca gcg cct cag ccc caa gca ttg gct ttg atg gct gca cag 30505 Ser Thr Ala Pro Gln Pro Gln Ala Leu Ala Leu Met Ala Ala Gln 6170 6175 6180 cct agc agc atg act gct aaa acc aat gag cag act act gaa ttt 30550 Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln Thr Thr Glu Phe 6185 6190 6195 ttg tcc act act cag agc agc acc aca gct acc tcg agt gcc ttc 30595 Leu Ser Thr Thr Gln Ser Ser Thr Thr Ala Thr Ser Ser Ala Phe 6200 6205 6210 tct agc acc gcc aat ctc acc tcg ctt tct tct acg cca atc agt 30640 Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro Ile Ser 6215 6220 6225 aat gct act acc tcc ccc gct cct ctt ccc act cct ctg aag caa 30685 Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys Gln 6230 6235 6240 tcc gag tct agc acg cag ctg cag atc acc ctg ctc att gtg atc 30730 Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 6245 6250 6255 ggg gtg gtc atc ctg gca gtg ctg ctc tac ttt atc ttc tgc cgc 30775 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg 6260 6265 6270 cgc atc ccc aac gcg aaa ccg gcc tac aag ccc att gtt atc ggg 30820 Arg Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly 6275 6280 6285 acg ccg gaa ccg ctt cag gtg gag gga ggt cta agg aat ctt ctc 30865 Thr Pro Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu 6290 6295 6300 ttc tct ttt aca gta tgg tgatttgaac t atg att cct aga cat ttc 30912 Phe Ser Phe Thr Val Trp Met Ile Pro Arg His Phe 6305 6310 6315 att atc act tct cta atc tgt gtg ctc caa gtc tgt gcc acc ctc 30957 Ile Ile Thr Ser Leu Ile Cys Val Leu Gln Val Cys Ala Thr Leu 6320 6325 6330 gct ctc gtg gct aac gcg agt cca gac tgc att gga gcg ttc gcc 31002 Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile Gly Ala Phe Ala 6335 6340 6345 tcc tac gtg ctc ttt gcc ttc atc acc tgc atc tgc tgc tgt agc 31047 Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys Cys Cys Ser 6350 6355 6360 ata gtc tgc ctg ctt atc acc ttc ttc cag ttc gtt gac tgg gtc 31092 Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Val Asp Trp Val 6365 6370 6375 ttt gtg cgc atc gcc tac ctg cgc cac cat ccc cag tac cgc gac 31137 Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg Asp 6380 6385 6390 cag aga gtg gcg caa ctg ttg aga ctc atc tg atg ata agc atg cgg 31184 Gln Arg Val Ala Gln Leu Leu Arg Leu Ile Met Ile Ser Met Arg 6395 6400 6405 gct ctg cta cta ctc ctc gcg ctt ctg cta gtt ccc ctc gcc gcc 31229 Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Val Pro Leu Ala Ala 6410 6415 6420 ccc tta tcc ttc aaa tcc ccc acc cag tcc cct gaa gag gtt cga 31274 Pro Leu Ser Phe Lys Ser Pro Thr Gln Ser Pro Glu Glu Val Arg 6425 6430 6435 aaa tgt aaa ttc caa gaa ccc tgg aaa ttc ctt tca tgc tac aaa 31319 Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys Tyr Lys 6440 6445 6450 ctc aaa tca gaa atg cac ccc agc tgg atc atg atc att gga atc 31364 Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Ile Gly Ile 6455 6460 6465 gtg aac atc ctt gcc tgt acc ctc ttc tcc ttt gtg att tac ccc 31409 Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 6470 6475 6480 cgc ttt gac ttt ggg tgg aac gca ccc gag gcg ctc tgg ctc ccg 31454 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro 6485 6490 6495 cct gat ccc gac ata cca cca cag cag cag caa aat cag gca cac 31499 Pro Asp Pro Asp Ile Pro Pro Gln Gln Gln Gln Asn Gln Ala His 6500 6505 6510 gca cca cca cca cag cct agg cca caa tac atg ccc atc tta gac 31544 Ala Pro Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp 6515 6520 6525 tat gag gcc gag cca cag cga gcc atg ctt cct gct att agt tac 31589 Tyr Glu Ala Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr 6530 6535 6540 ttc aac cta acc ggc gga gat gac tgaccccatg gccaacaaca ccgtcaacga 31643 Phe Asn Leu Thr Gly Gly Asp Asp 6545 cctcctggac atggacggcc gcgcctcgga gcagcgactc gcccaactcc gcatccgcca 31703 gcagcaggag agagccgtca aggagctgca ggatgcggtg gctatccacc agtgcaagag 31763 aggcatcttc tgcctggtga agcaggccaa gatcaccttc gaggtgactt ccaccgacca 31823 tcgcctctcc tacgagctcc tgcagcagcg ccagaagttc acctgcctgg tcggagtcaa 31883 ccccatcgtc atcacccagc agtctggcga taccaagggg tgcatccact gctcctgcga 31943 ctcccccgag tgccttcaca ccctggtcaa gaccctctgc ggcctccgcg acctcctccc 32003 catgaactaa tcaactaacc cctacccctt taccctccag taaaaaataa agattaaaaa 32063 atgattgaat tgatcaataa agaatcactt acttgaaatc tgaaaccagg tctctgtcca 32123 tgttttctgt cagcagcact tcactcccct cttcccagct ctggtactgc aggccccggc 32183 gggctgcaaa cttcctccac actctgaagg ggatgtcaaa ttcctcctgt ccctcaatct 32243 tcatttttat cttctatcag atg tcc aaa aag cgc gcg cgg gtg gat gat 32293 Met Ser Lys Lys Arg Ala Arg Val Asp Asp 6550 6555 ggc ttc gac ccc gtg tac ccc tac gat gca gac aac gca ccg act 32338 Gly Phe Asp Pro Val Tyr Pro Tyr Asp Ala Asp Asn Ala Pro Thr 6560 6565 6570 gtg ccc ttc atc aac cct ccc ttc gtc tct tca gat gga ttc caa 32383 Val Pro Phe Ile Asn Pro Pro Phe Val Ser Ser Asp Gly Phe Gln 6575 6580 6585 gaa aag ccc ttg ggg gtg ttg tcc ctg cgc ctg gcc gac ccc gtc 32428 Glu Lys Pro Leu Gly Val Leu Ser Leu Arg Leu Ala Asp Pro Val 6590 6595 6600 acc acc aag aac ggg gct gtc acc ctc aag ctg ggg gag ggg gtg 32473 Thr Thr Lys Asn Gly Ala Val Thr Leu Lys Leu Gly Glu Gly Val 6605 6610 6615 gac ctc gac gac tcg gga aaa ctc att gca aac aca gtc agc aag 32518 Asp Leu Asp Asp Ser Gly Lys Leu Ile Ala Asn Thr Val Ser Lys 6620 6625 6630 gcc att gcc cct ctc agt ttt tcc aac aac acc att tcc ctt aac 32563 Ala Ile Ala Pro Leu Ser Phe Ser Asn Asn Thr Ile Ser Leu Asn 6635 6640 6645 atg gat acc cct tta tat acc aaa gat gga aaa cta tcc tta caa 32608 Met Asp Thr Pro Leu Tyr Thr Lys Asp Gly Lys Leu Ser Leu Gln 6650 6655 6660 gtt tct cca cca tta aat ata tta aga tca acg att ctg aac aca 32653 Val Ser Pro Pro Leu Asn Ile Leu Arg Ser Thr Ile Leu Asn Thr 6665 6670 6675 tta gct cta gct ttt ggc tca ggt tta gga ctc agt ggc agc gcc 32698 Leu Ala Leu Ala Phe Gly Ser Gly Leu Gly Leu Ser Gly Ser Ala 6680 6685 6690 ctg gca gta cag tta gcc tct cca ctt aca ttt gat gat aaa gga 32743 Leu Ala Val Gln Leu Ala Ser Pro Leu Thr Phe Asp Asp Lys Gly 6695 6700 6705 aat ata aag att acc cta gac agg gga ttg cat gtt acg aca gga 32788 Asn Ile Lys Ile Thr Leu Asp Arg Gly Leu His Val Thr Thr Gly 6710 6715 6720 aat gca att gaa agc aac ata agc tgg gct aaa ggt ata aaa ttt 32833 Asn Ala Ile Glu Ser Asn Ile Ser Trp Ala Lys Gly Ile Lys Phe 6725 6730 6735 gaa gat gga gcc ata gct gcc aac att ggt aaa ggg cta gag ttt 32878 Glu Asp Gly Ala Ile Ala Ala Asn Ile Gly Lys Gly Leu Glu Phe 6740 6745 6750 ggc acc agt agt aca gta aca ggt gtt gac gac gct tat cca ata 32923 Gly Thr Ser Ser Thr Val Thr Gly Val Asp Asp Ala Tyr Pro Ile 6755 6760 6765 caa gtt aaa ctt gga tct ggt ctt agc ttt gat agc aca ggg gct 32968 Gln Val Lys Leu Gly Ser Gly Leu Ser Phe Asp Ser Thr Gly Ala 6770 6775 6780 atc atg gct ggc aat aag gag gat gac aaa ctt act tta tgg aca 33013 Ile Met Ala Gly Asn Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr 6785 6790 6795 aca cct gat cca tcg cca aat tgt caa ata ctc gca gaa aat gat 33058 Thr Pro Asp Pro Ser Pro Asn Cys Gln Ile Leu Ala Glu Asn Asp 6800 6805 6810 gca aaa cta aca ctt tgc tta aca aag tgt ggt agt caa ata ttg 33103 Ala Lys Leu Thr Leu Cys Leu Thr Lys Cys Gly Ser Gln Ile Leu 6815 6820 6825 gcc act gta tca gtc tta gtg gta gga agt gga aag tta aac cca 33148 Ala Thr Val Ser Val Leu Val Val Gly Ser Gly Lys Leu Asn Pro 6830 6835 6840 att act ggg gaa gta agc agt gct caa gtc ttt cta cga ttt gat 33193 Ile Thr Gly Glu Val Ser Ser Ala Gln Val Phe Leu Arg Phe Asp 6845 6850 6855 tct aat gga gta ctc tta gta aac agc tcc aca ttg aaa aag tat 33238 Ser Asn Gly Val Leu Leu Val Asn Ser Ser Thr Leu Lys Lys Tyr 6860 6865 6870 tgg ggg tat agg cag ggt gac agc ata gat ggt act cca tac acc 33283 Trp Gly Tyr Arg Gln Gly Asp Ser Ile Asp Gly Thr Pro Tyr Thr 6875 6880 6885 aac gcc gta ggt ttc atg cca aat tta aaa gct tac cca aag tcc 33328 Asn Ala Val Gly Phe Met Pro Asn Leu Lys Ala Tyr Pro Lys Ser 6890 6895 6900 caa agt tct act act aaa aat aat ata gtg gga caa gta tac atg 33373 Gln Ser Ser Thr Thr Lys Asn Asn Ile Val Gly Gln Val Tyr Met 6905 6910 6915 aat ggt gat aat tca aaa cct atg ctt ctt act ata act ctc aat 33418 Asn Gly Asp Asn Ser Lys Pro Met Leu Leu Thr Ile Thr Leu Asn 6920 6925 6930 ggc act gat gat acc acc agt gca tat tca atg tca ttt tca tac 33463 Gly Thr Asp Asp Thr Thr Ser Ala Tyr Ser Met Ser Phe Ser Tyr 6935 6940 6945 acc tgg act aat gga agt tat acc gga gca aca ttt gga gct aac 33508 Thr Trp Thr Asn Gly Ser Tyr Thr Gly Ala Thr Phe Gly Ala Asn 6950 6955 6960 tca tac aca ttt tcc tac att gcc caa gaa taatcccacc ctgcatgcca 33558 Ser Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 6965 6970 accccttttc ccactctata aatggaactg aaacaaaaat aaagttcaag tgtttttatt 33618 gattcaacag ttttcacagg attcgagtag ttattttccc tcctccctcc caactcatgg 33678 aatacaccac cctctcccca cgcacagcct taaacatctg aatgccattg gtaatggaca 33738 tggttttggt ctccacattc cacacagttt cagagcgagc cagtctcggg tcggtcaggg 33798 agatgaaacc ctccgggcac tcctgcatct gcacctcaaa gttcagtagc tgagggctgt 33858 cctcggtggt cgggatcaca gttatctgga agaagagcga tgagagtcat aatccgcgaa 33918 cgggatcggg cggttgtggc gcatcaggcc ccgcagcagt cgctgtctgc gccgctccgt 33978 caagctgctg cttaaggggt ccgggtccag ggactccctg cgcatgatgc caatggccct 34038 gagcatcagt cgcctggtgc ggcgggcgca gcagcggatg cggatctcac tcaggtcgga 34098 gcagtacgtg cagcacagca ctaccaagtt gttcaacagt ccatagttca acgtgctcca 34158 gccaaaactc atctgtggaa ctatgctgcc cacatgtcca tcgtaccaga tcctgatgta 34218 aatcaggtgg cgccccctcc agaacacact gcccatgtac atgatctcct tgggcatatg 34278 caggttcacc acctcccggt accacatcac ccgctggttg aacatgcagc cctggataat 34338 cctgcggaac cagatggcca gtaccgcccc gcccgccatg cagcgaaggg accccgggtc 34398 ctgacagtgg cagtggatga tccaccgctc gcggccgtgg atcaactggg aactgaacaa 34458 gtctatgttg gcacagcaca ggcacacgct catgcatgtc ttcagcactc tcagctcctc 34518 gggggtcagg accatgtccc agggcacggg gaactcttgc aggacagtga acccggcaga 34578 acaaggcaac cctcgcacac aacttacatt gtgcatggac agggtatcgc aatcaggcag 34638 caccggatga tcctccacca gagaagcgcg ggtctcggtc tcctcacagc gaggtaaggg 34698 ggccgggggt tggtacggat gatggcggga tgacgctaat cgtgttctgg atcgtgtcat 34758 gatggagctg tttcctgaca ttttcgtact tcacgaagca gaacctggta cgggcactgc 34818 acaccgctcg tcggcgacgg tctcggcgct tcgagcgctc ggtgttgaag ttatagaaca 34878 gccactccct cagagcatgc agtatctcct gagcctcttg ggtgatgaaa atcccatccg 34938 ccctgatggc tctgatcaca tcgaccacgg tggaatgggc cagacccagc cagatgatgc 34998 aattttgttg ggtttcggtg acggcggggg agggaagaac aggaagaacc atgattaact 35058 ttattccaaa cggtctcgga gcacttcaaa atgcaggtcc cggagatggc acctctcgcc 35118 cccactgtgt tggtggaaaa taacagccag gtcaaaggtg acacggttct cgagatgttc 35178 cacggtggct tccagtaaag cctccacgcg cacatccaga aacaagagga cagcgaaagc 35238 gggagcgttt tctaattcct caatcatcat attacactcc tgcaccatcc ccagataatt 35298 ttcatttttc cagccttgaa tgattcgtat tagttcctgg ggtaaatcca agccagccat 35358 gataaaaagc tcgcgcagag cgccctccac cggcattctt aagcacactc tcataattcc 35418 aagagattct gctcctggtt cacctgcagc agattaacaa tgggaatatc aaaatctctg 35478 ccgcgatccc taagctcctc cctcaacaat aactgtatgt aatctttcat gtcatctccg 35538 aaatttttag ccatagggcc gccaggaata agagaagggc aagccacatt acagataaag 35598 cgaagtcctc cccagtgagc attgccaaat gtaagattga aataagcatg ctggctagac 35658 ccggtgatat cctccagata actggacaga aaatcaggca agcaattttt aagaaaatca 35718 acaaaagaaa agtcgtccag gtgcacgttt agagcctcgg gaacaacgat ggaataagtg 35778 caaggagtgc gctccagcat ggttagtgtt ttttggtgat ctgtagaaca aaaaaataaa 35838 catgcaatat taaaccatgc tagcctggcg aacaggtggg taaatcactc tttccagcac 35898 caggcaggct acggggtctc cggcgcgacc ctcgtagaaa ctgtcgccat gattgaaaag 35958 catcaccgag agaccttccc ggtgaccggc atggatgatt cgagaagaag catacactcc 36018 gggaacattg gcgtccgtga gtgaaaaaaa gcgacctata aagcctcgag ggactacaat 36078 gctcaatctc aattccagca aagcgacccc atgcggatga agcacaaaat tggcaggtgc 36138 gtaaaaaatg taattactcc cctcctgcac aggcagcaaa gcccccgctc cctccagaaa 36198 cacatacaaa gcctcagcgt ccatagctta ccgagcacgg caggcgcaag agtcagagaa 36258 aaggctgagc tctaacctga ctgcccgctc ctgtgctcaa tatatagccc taacctacac 36318 tgacgtaaag gccaaagtct aaaaataccc gccaaaatga cacacacgcc cagcacacgc 36378 ccagaaaccg gtgacacact caaaaaaata cgtgcgcttc ctcaaacgcc caaaccggcg 36438 tcatttccgg gttcccacgc tacgtcacct atcagcgact ttcaaattcc gtcgaccgtt 36498 aaaaacgtca ctcgccccgc ccctaacggt cgcccttccc gcagccaatc acaacccttc 36558 ctccccaaat tcaaacgcct catttgcata ttaacgcgca caaaaagttt gaggtatatt 36618 attgatgatg 36628 <210> 163 <211> 499 <212> PRT <213> Simian adenovirus 26 <400> 163 Met Glu Ser Arg Asn Pro Phe Gln Gln Gly Leu Pro Ala Gly Phe Leu 1 5 10 15 Ser Ser Ser Phe Val Glu Asn Met Glu Val Pro Ala Pro Glu Cys Asn 20 25 30 Leu Arg Leu Leu Ala Gly Thr Ala Ala Arg His Ser Glu Asp Pro Glu 35 40 45 Ser Pro Gly Glu Ser Gln Gly Thr Pro Thr Ser Pro Ala Ala Ala Ala 50 55 60 Ala Ala Gly Gly Gly Ser Arg Arg Glu Pro Glu Ser Arg Pro Gly Pro 65 70 75 80 Ser Gly Gly Gly Gly Val Ala Asp Leu Phe Pro Glu Leu Arg Arg Val 85 90 95 Leu Thr Arg Ser Ser Ser Gly Arg Glu Arg Gly Ile Lys Arg Glu Arg 100 105 110 His Asp Glu Thr Asn His Arg Thr Glu Leu Thr Val Gly Leu Met Ser 115 120 125 Arg Lys Arg Pro Glu Thr Val Trp Trp His Glu Val Gln Ser Thr Gly 130 135 140 Thr Asp Glu Val Ser Val Met His Glu Arg Phe Ser Leu Glu Gln Val 145 150 155 160 Lys Thr Cys Trp Leu Glu Pro Glu Asp Asp Trp Glu Val Ala Ile Arg 165 170 175 Asn Tyr Ala Lys Leu Ala Leu Arg Pro Asp Lys Lys Tyr Lys Ile Thr 180 185 190 Lys Leu Ile Asn Ile Arg Asn Ala Cys Tyr Ile Ser Gly Asn Gly Ala 195 200 205 Glu Val Glu Ile Cys Leu Gln Asp Arg Val Ala Phe Arg Cys Cys Met 210 215 220 Met Asn Met Tyr Pro Gly Val Val Gly Met Asp Gly Val Thr Phe Met 225 230 235 240 Asn Met Arg Phe Arg Gly Asp Gly Tyr Asn Gly Thr Val Phe Met Ala 245 250 255 Asn Thr Lys Leu Thr Val His Gly Cys Ser Phe Phe Gly Phe Asn Asn 260 265 270 Thr Cys Ile Glu Ala Trp Gly Gln Val Gly Val Arg Gly Cys Ser Phe 275 280 285 Ser Ala Asn Trp Met Gly Val Val Gly Arg Thr Lys Ser Met Leu Ser 290 295 300 Val Lys Lys Cys Leu Phe Glu Arg Cys His Leu Gly Val Met Ser Glu 305 310 315 320 Gly Glu Ala Arg Ile Arg His Cys Ala Ser Thr Glu Thr Gly Cys Phe 325 330 335 Val Leu Cys Lys Gly Asn Ala Lys Ile Lys His Asn Met Ile Cys Gly 340 345 350 Ala Ser Asp Glu Arg Gly Tyr Gln Met Leu Thr Cys Ala Gly Gly Asn 355 360 365 Ser His Met Leu Ala Thr Val His Val Ala Ser His Ser Arg Lys Pro 370 375 380 Trp Pro Glu Phe Glu His Asn Val Met Thr Arg Cys Asn Met His Leu 385 390 395 400 Gly Ser Arg Arg Gly Met Phe Met Pro Tyr Gln Cys Asn Leu Asn Tyr 405 410 415 Val Lys Val Leu Leu Glu Pro Asp Ala Met Ser Arg Val Ser Leu Thr 420 425 430 Gly Val Phe Asp Met Asn Val Glu Val Trp Lys Ile Leu Arg Tyr Asp 435 440 445 Glu Ser Lys Thr Arg Cys Arg Ala Cys Glu Cys Gly Gly Lys His Ala 450 455 460 Arg Phe Gln Pro Val Cys Val Glu Val Thr Glu Asp Leu Arg Pro Asp 465 470 475 480 His Leu Val Leu Ser Cys Thr Gly Thr Glu Phe Gly Ser Ser Gly Glu 485 490 495 Glu Ser Asp <210> 164 <211> 142 <212> PRT <213> Simian adenovirus 26 <400> 164 Met Ser Gly Ser Gly Ser Phe Glu Gly Gly Val Phe Ser Pro Tyr Leu 1 5 10 15 Thr Gly Arg Leu Pro Ser Trp Ala Gly Val Arg Gln Asn Val Met Gly 20 25 30 Ser Thr Val Asp Gly Arg Pro Val Gln Pro Ala Asn Ser Ser Thr Leu 35 40 45 Thr Tyr Ala Thr Leu Ser Ser Ser Ser Val Asp Ala Ala Ala Ala Ala 50 55 60 Ala Ala Ala Ser Ala Ala Ser Ala Val Arg Gly Met Ala Met Gly Ala 65 70 75 80 Gly Tyr Tyr Gly Thr Leu Val Ala Asn Ser Ser Ser Thr Asn Asn Pro 85 90 95 Ala Ser Leu Asn Glu Glu Lys Leu Leu Leu Leu Met Ala Gln Leu Glu 100 105 110 Ala Leu Thr Gln Arg Leu Gly Glu Leu Thr Gln Gln Val Ala Gln Leu 115 120 125 Gln Glu Gln Thr Arg Ala Ala Val Ala Thr Val Lys Ser Lys 130 135 140 <210> 165 <211> 464 <212> PRT <213> Simian adenovirus 26 <400> 165 Met Lys Leu Val Ser Ala Glu Ser Gly Arg Pro Arg Trp Leu Ala Ala 1 5 10 15 Val Val Trp Arg Arg Ile Ala Arg Val Ala Leu Arg Cys Ala Pro Val 20 25 30 Arg Ser Arg Pro Asp Ser Ala Ala Asn Glu Gly Val Ala Ala Pro Ser 35 40 45 Phe Pro Arg Pro Pro Ser Gln Pro Thr Ser Pro Val Thr Glu Arg Ala 50 55 60 Pro Leu Leu Phe Phe Cys Phe Cys Gln Met His Pro Val Leu Arg Gln 65 70 75 80 Met Arg Pro His His Pro Pro Pro Gln Gln Gln Pro Pro Pro Gln Pro 85 90 95 Ala Leu Leu Pro Pro Pro Gln Gln Gln Gln Gln Leu Pro Ala Thr Thr 100 105 110 Ala Ala Ala Ala Val Ser Gly Ala Gly Gln Thr Ser Gln Tyr Asp Leu 115 120 125 Ala Leu Glu Glu Gly Glu Gly Leu Ala Arg Leu Gly Ala Ser Ser Pro 130 135 140 Glu Arg His Pro Arg Val Gln Met Lys Arg Asp Ala Arg Glu Ala Tyr 145 150 155 160 Val Pro Lys Gln Asn Leu Phe Arg Asp Arg Ser Gly Glu Glu Pro Glu 165 170 175 Glu Met Arg Ala Ala Arg Phe His Ala Gly Arg Glu Leu Arg Arg Gly 180 185 190 Leu Asp Arg Lys Arg Val Leu Arg Asp Glu Asp Phe Glu Ala Asp Glu 195 200 205 Leu Thr Gly Ile Ser Pro Ala Arg Ala His Val Ala Ala Ala Asn Leu 210 215 220 Val Thr Ala Tyr Glu Gln Thr Val Lys Glu Glu Ser Asn Phe Gln Lys 225 230 235 240 Ser Phe Asn Asn His Val Arg Thr Leu Ile Ala Arg Glu Glu Val Thr 245 250 255 Leu Gly Leu Met His Leu Trp Asp Leu Leu Glu Ala Ile Val Gln Asn 260 265 270 Pro Thr Ser Lys Pro Leu Thr Ala Gln Leu Phe Leu Val Val Gln His 275 280 285 Ser Arg Asp Asn Glu Ala Phe Arg Glu Ala Leu Leu Asn Ile Thr Glu 290 295 300 Pro Glu Gly Arg Trp Leu Leu Asp Leu Val Asn Ile Leu Gln Ser Ile 305 310 315 320 Val Val Gln Glu Arg Gly Leu Pro Leu Ser Glu Lys Leu Ala Ala Ile 325 330 335 Asn Phe Ser Val Leu Ser Leu Gly Lys Tyr Tyr Ala Arg Lys Ile Tyr 340 345 350 Lys Thr Pro Tyr Val Pro Ile Asp Lys Glu Val Lys Ile Asp Gly Phe 355 360 365 Tyr Met Arg Met Thr Leu Lys Val Leu Thr Leu Ser Asp Asp Leu Gly 370 375 380 Val Tyr Arg Asn Asp Arg Met His Arg Ala Val Ser Ala Ser Arg Arg 385 390 395 400 Arg Glu Leu Ser Asp Gln Glu Leu Met His Ser Leu Gln Arg Ala Leu 405 410 415 Thr Gly Ala Gly Thr Glu Gly Glu Ser Tyr Phe Asp Met Gly Ala Asp 420 425 430 Leu His Trp Gln Pro Ser Arg Arg Ala Leu Glu Ala Ala Gly Pro Pro 435 440 445 Tyr Val Glu Glu Val Asp Glu Asp Glu Glu Gly Glu Tyr Leu Glu Asp 450 455 460 <210> 166 <211> 592 <212> PRT <213> Simian adenovirus 26 <400> 166 Met Gln Gln Gln Pro Pro Pro Asp Pro Ala Met Arg Ala Ala Leu Gln 1 5 10 15 Ser Gln Pro Ser Gly Ile Asn Ser Ser Asp Asp Trp Thr Gln Ala Met 20 25 30 Gln Arg Ile Met Ala Leu Thr Thr Arg Asn Pro Glu Ala Phe Arg Gln 35 40 45 Gln Pro Gln Ala Asn Arg Leu Ser Ala Ile Leu Glu Ala Val Val Pro 50 55 60 Ser Arg Ser Asn Pro Thr His Glu Lys Val Leu Ala Ile Val Asn Ala 65 70 75 80 Leu Val Glu Asn Lys Ala Ile Arg Gly Asp Glu Ala Gly Leu Val Tyr 85 90 95 Asn Ala Leu Leu Glu Arg Val Ala Arg Tyr Asn Ser Thr Asn Val Gln 100 105 110 Thr Asn Leu Asp Arg Met Val Thr Asp Val Arg Glu Ala Val Ala Gln 115 120 125 Arg Glu Arg Phe His Arg Glu Ser Asn Leu Gly Ser Met Val Ala Leu 130 135 140 Asn Ala Phe Leu Ser Thr Gln Pro Ala Asn Val Pro Arg Gly Gln Glu 145 150 155 160 Asp Tyr Thr Asn Phe Ile Ser Ala Leu Arg Leu Met Val Thr Glu Val 165 170 175 Pro Gln Ser Glu Val Tyr Gln Ser Gly Pro Asp Tyr Phe Phe Gln Thr 180 185 190 Ser Arg Gln Gly Leu Gln Thr Val Asn Leu Ser Gln Ala Phe Lys Asn 195 200 205 Leu Gln Gly Leu Trp Gly Val Gln Ala Pro Val Gly Asp Arg Ala Thr 210 215 220 Val Ser Ser Leu Leu Thr Pro Asn Ser Arg Leu Leu Leu Leu Leu Val 225 230 235 240 Ala Pro Phe Thr Asp Ser Gly Ser Ile Asn Arg Asn Ser Tyr Leu Gly 245 250 255 Tyr Leu Ile Asn Leu Tyr Arg Glu Ala Ile Gly Gln Ala His Val Asp 260 265 270 Glu Gln Thr Tyr Gln Glu Ile Thr His Val Ser Arg Ala Leu Gly Gln 275 280 285 Asp Asp Pro Gly Asn Leu Glu Ala Thr Leu Asn Phe Leu Leu Thr Asn 290 295 300 Arg Ser Gln Lys Ile Pro Pro Gln Tyr Ala Leu Ser Ala Glu Glu Glu 305 310 315 320 Arg Ile Leu Arg Tyr Val Gln Gln Ser Val Gly Leu Phe Leu Met Gln 325 330 335 Glu Gly Ala Thr Pro Ser Ala Ala Leu Asp Met Thr Ala Arg Asn Met 340 345 350 Glu Pro Ser Met Tyr Ala Ser Asn Arg Pro Phe Ile Asn Lys Leu Met 355 360 365 Asp Tyr Leu His Arg Ala Ala Ala Met Asn Ser Asp Tyr Phe Thr Asn 370 375 380 Ala Ile Leu Asn Pro His Trp Leu Pro Pro Pro Gly Phe Tyr Thr Gly 385 390 395 400 Glu Tyr Asp Met Pro Asp Pro Asn Asp Gly Phe Leu Trp Asp Asp Val 405 410 415 Asp Ser Ser Val Phe Ser Pro Arg Pro Gly Ala Asn Glu Arg Pro Leu 420 425 430 Trp Lys Lys Glu Gly Ser Asp Arg Arg Pro Ser Ser Ala Leu Ser Gly 435 440 445 Arg Glu Gly Ala Ala Ala Ala Val Pro Glu Ala Ala Ser Pro Phe Pro 450 455 460 Ser Leu Pro Phe Ser Leu Asn Ser Ile Arg Ser Ser Glu Leu Gly Arg 465 470 475 480 Ile Thr Arg Pro Arg Leu Leu Gly Glu Glu Glu Tyr Leu Asn Asp Ser 485 490 495 Leu Leu Arg Pro Glu Arg Glu Lys Asn Phe Pro Asn Asn Gly Ile Glu 500 505 510 Ser Leu Val Asp Lys Met Ser Arg Trp Lys Thr Tyr Ala Gln Glu His 515 520 525 Arg Asp Asp Pro Arg Ala Ser Gln Gly Ala Ala Ser Arg Gly Ser Ala 530 535 540 Ala Arg Lys Arg Arg Trp His Asp Arg Gln Arg Gly Leu Met Trp Asp 545 550 555 560 Asp Glu Asp Ser Ala Asp Asp Ser Ser Val Leu Asp Leu Gly Gly Ser 565 570 575 Gly Gly Asn Pro Phe Ala His Leu Arg Pro Arg Ile Gly Arg Met Met 580 585 590 <210> 167 <211> 546 <212> PRT <213> Simian adenovirus 26 <400> 167 Met Met Arg Arg Ala Tyr Pro Glu Gly Pro Pro Pro Ser Tyr Glu Ser 1 5 10 15 Val Met Gln Gln Ala Met Ala Ala Ala Ala Ala Met Gln Pro Pro Leu 20 25 30 Glu Ala Pro Tyr Val Pro Pro Arg Tyr Leu Ala Pro Thr Glu Gly Arg 35 40 45 Asn Ser Ile Arg Tyr Ser Glu Leu Ala Pro Leu Tyr Asp Thr Thr Arg 50 55 60 Leu Tyr Leu Val Asp Asn Lys Ser Ala Asp Ile Ala Ser Leu Asn Tyr 65 70 75 80 Gln Asn Asp His Ser Asn Phe Leu Thr Thr Val Val Gln Asn Asn Asp 85 90 95 Phe Thr Pro Thr Glu Ala Ser Thr Gln Thr Ile Asn Phe Asp Glu Arg 100 105 110 Ser Arg Trp Gly Gly Gln Leu Lys Thr Ile Met His Thr Asn Met Pro 115 120 125 Asn Val Asn Glu Phe Met Tyr Ser Asn Lys Phe Lys Ala Arg Val Met 130 135 140 Val Ser Arg Lys Thr Pro Asn Gly Val Thr Val Thr Asp Gly Ser Gln 145 150 155 160 Asp Glu Leu Lys Tyr Glu Trp Val Glu Phe Glu Leu Pro Glu Gly Asn 165 170 175 Phe Ser Val Thr Met Thr Ile Asp Leu Met Asn Asn Ala Ile Ile Asp 180 185 190 Asn Tyr Leu Ala Val Gly Arg Gln Asn Gly Val Leu Glu Ser Asp Ile 195 200 205 Gly Val Lys Phe Asp Thr Arg Asn Phe Arg Leu Gly Trp Asp Pro Val 210 215 220 Thr Glu Leu Val Met Pro Gly Val Tyr Thr Asn Glu Ala Phe His Pro 225 230 235 240 Asp Ile Val Leu Leu Pro Gly Cys Gly Val Asp Phe Thr Glu Ser Arg 245 250 255 Leu Ser Asn Leu Leu Gly Ile Arg Lys Arg Gln Pro Phe Gln Glu Gly 260 265 270 Phe Gln Ile Met Tyr Glu Asp Leu Glu Gly Gly Asn Ile Pro Ala Leu 275 280 285 Leu Asp Val Glu Ala Tyr Glu Lys Ser Lys Glu Glu Asn Ala Ala Ala 290 295 300 Glu Ala Val Ala Thr Ala Ala Thr Ala Glu Ala Lys Ala Val Val Asp 305 310 315 320 Ala Asp Ala Asn Val Thr Arg Gly Asp Thr Phe Ala Thr Gln Ala Glu 325 330 335 Glu Ala Ala Ala Leu Ala Val Ala Asp Asp Ser Glu Ser Thr Lys Thr 340 345 350 Val Thr Ile Gln Pro Val Lys Val Asp Ser Lys Asn Arg Ser Tyr Asn 355 360 365 Val Leu Pro Asp Glu Lys Asn Thr Ala Tyr Arg Ser Trp Tyr Leu Ala 370 375 380 Tyr Asn Tyr Gly Asp Pro Glu Lys Gly Val Arg Ser Trp Thr Leu Leu 385 390 395 400 Thr Thr Ser Asp Val Thr Cys Gly Val Glu Gln Val Tyr Trp Ser Leu 405 410 415 Pro Asp Met Met Gln Asp Pro Val Thr Phe Arg Ser Thr Arg Gln Val 420 425 430 Ser Asn Tyr Pro Val Val Gly Ala Glu Leu Leu Pro Val Tyr Ser Lys 435 440 445 Ser Phe Phe Asn Glu Gln Ala Val Tyr Ser Gln Gln Leu Arg Ala Phe 450 455 460 Thr Ser Leu Thr His Val Phe Asn Arg Phe Pro Glu Asn Gln Ile Leu 465 470 475 480 Val Arg Pro Pro Ala Pro Thr Ile Thr Thr Val Ser Glu Asn Val Pro 485 490 495 Ala Leu Thr Asp His Gly Thr Leu Pro Leu Arg Ser Ser Ile Arg Gly 500 505 510 Val Gln Arg Val Thr Val Thr Asp Ala Arg Arg Arg Thr Cys Pro Tyr 515 520 525 Val Tyr Lys Ala Leu Gly Ile Val Ala Pro Arg Val Leu Ser Ser Arg 530 535 540 Thr Phe 545 <210> 168 <211> 193 <212> PRT <213> Simian adenovirus 26 <400> 168 Met Ser Ile Leu Ile Ser Pro Ser Asn Asn Thr Gly Trp Gly Leu Arg 1 5 10 15 Ala Pro Ser Lys Met Tyr Gly Gly Ala Arg Gln Arg Ser Thr Gln His 20 25 30 Pro Val Arg Val Arg Gly His Phe Arg Ala Pro Trp Gly Ala Leu Lys 35 40 45 Gly Arg Val Arg Ser Arg Thr Thr Val Asp Asp Val Ile Asp Gln Val 50 55 60 Val Ala Asp Ala Arg Asn Tyr Thr Pro Ala Ala Ala Pro Val Ser Thr 65 70 75 80 Val Asp Ala Val Ile Asp Ser Val Val Ala Asp Ala Arg Arg Tyr Ala 85 90 95 Arg Ala Lys Ser Arg Arg Arg Arg Ile Ala Arg Arg His Arg Ser Thr 100 105 110 Pro Ala Met Arg Ala Ala Arg Ala Leu Leu Arg Arg Ala Arg Arg Thr 115 120 125 Gly Arg Arg Ala Met Leu Arg Ala Ala Arg Arg Ala Ala Ser Gly Ala 130 135 140 Ser Ala Gly Arg Thr Arg Arg Arg Ala Ala Thr Ala Ala Ala Ala Ala 145 150 155 160 Ile Ala Ser Met Ser Arg Pro Arg Arg Gly Asn Val Tyr Trp Val Arg 165 170 175 Asp Ala Ala Thr Gly Val Arg Val Pro Val Arg Thr Arg Pro Pro Arg 180 185 190 Thr <210> 169 <211> 339 <212> PRT <213> Simian adenovirus 26 <400> 169 Met Ser Lys Arg Lys Phe Lys Glu Glu Met Leu Gln Val Ile Ala Pro 1 5 10 15 Glu Ile Tyr Gly Pro Ala Val Val Lys Glu Glu Arg Lys Pro Arg Lys 20 25 30 Ile Lys Arg Val Lys Lys Asp Lys Lys Glu Glu Asp Asp Asp Leu Val 35 40 45 Glu Phe Val Arg Glu Phe Ala Pro Arg Arg Arg Val Gln Trp Arg Gly 50 55 60 Arg Lys Val Gln Pro Val Leu Arg Pro Gly Thr Thr Val Val Phe Thr 65 70 75 80 Pro Gly Glu Arg Ser Gly Thr Ala Ser Lys Arg Ser Tyr Asp Glu Val 85 90 95 Tyr Gly Asp Asp Asp Ile Leu Glu Gln Ala Ala Glu Arg Leu Gly Glu 100 105 110 Phe Ala Tyr Gly Lys Arg Ser Arg Ser Ala Pro Lys Glu Glu Ala Val 115 120 125 Ser Ile Pro Leu Asp His Gly Asn Pro Thr Pro Ser Leu Lys Pro Val 130 135 140 Thr Leu Gln Gln Val Leu Pro Ser Ala Ala Pro Arg Arg Gly Phe Lys 145 150 155 160 Arg Glu Gly Glu Asp Leu Tyr Pro Thr Met Gln Leu Met Val Pro Lys 165 170 175 Arg Gln Lys Leu Glu Asp Val Leu Glu Thr Met Lys Val Asp Pro Asp 180 185 190 Val Gln Pro Glu Val Lys Val Arg Pro Ile Lys Gln Val Ala Pro Gly 195 200 205 Leu Gly Val Gln Thr Val Asp Ile Lys Ile Pro Thr Glu Pro Met Glu 210 215 220 Thr Gln Thr Glu Pro Val Lys Pro Ser Thr Ser Thr Met Glu Val Gln 225 230 235 240 Thr Asp Pro Trp Met Pro Ala Ala Pro Thr Thr Arg Arg Pro Arg Arg 245 250 255 Lys Tyr Gly Ala Ala Ser Leu Leu Met Pro Asn Tyr Ala Leu His Pro 260 265 270 Ser Ile Ile Pro Thr Pro Gly Tyr Arg Gly Thr Arg Phe Tyr Arg Gly 275 280 285 His Thr Ser Arg Arg Arg Lys Thr Thr Thr Arg Arg Arg Arg Arg Arg 290 295 300 Thr Ala Ala Ala Ser Thr Pro Ala Ala Leu Val Arg Arg Val Tyr Arg 305 310 315 320 Arg Gly Arg Ala Pro Leu Thr Leu Pro Arg Ala Arg Tyr His Pro Ser 325 330 335 Ile Ala Ile <210> 170 <211> 77 <212> PRT <213> Simian adenovirus 26 <400> 170 Met Ala Leu Thr Cys Arg Leu Arg Val Pro Ile Thr Gly Tyr Arg Gly 1 5 10 15 Arg Lys Pro Arg Arg Arg Arg Leu Ala Gly Asn Gly Met Arg Arg His 20 25 30 His His Arg Arg Arg Arg Ala Ile Ser Lys Arg Leu Gly Gly Gly Phe 35 40 45 Leu Pro Ala Leu Ile Pro Ile Ile Ala Ala Ala Ile Gly Ala Ile Pro 50 55 60 Gly Ile Ala Ser Val Ala Val Gln Ala Ser Gln Arg His 65 70 75 <210> 171 <211> 258 <212> PRT <213> Simian adenovirus 26 <400> 171 Met Asp Ser Asp Ala Pro Gly Pro Val Met Cys Phe Arg Arg Gln Met 1 5 10 15 Glu Asp Ile Asn Phe Ser Ser Leu Ala Pro Arg His Gly Thr Arg Pro 20 25 30 Phe Met Gly Thr Trp Ser Asp Ile Gly Thr Ser Gln Leu Asn Gly Gly 35 40 45 Ala Phe Asn Trp Ser Ser Leu Trp Ser Gly Leu Lys Asn Phe Gly Ser 50 55 60 Thr Leu Lys Thr Tyr Gly Ser Lys Ala Trp Asn Ser Thr Thr Gly Gln 65 70 75 80 Ala Leu Arg Asp Lys Leu Lys Glu Gln Asn Phe Gln Gln Lys Val Val 85 90 95 Asp Gly Leu Ala Ser Gly Ile Asn Gly Val Val Asp Leu Ala Asn Gln 100 105 110 Ala Val Gln Arg Gln Ile Asn Ser Arg Leu Asp Pro Val Pro Pro Ala 115 120 125 Gly Ser Val Glu Met Pro Gln Val Glu Glu Glu Leu Pro Pro Leu Asp 130 135 140 Lys Arg Gly Glu Lys Arg Pro Arg Pro Asp Ala Glu Glu Thr Leu Leu 145 150 155 160 Thr His Thr Asp Glu Pro Pro Pro Tyr Glu Glu Ala Val Lys Leu Gly 165 170 175 Leu Pro Thr Thr Arg Pro Ile Ala Pro Leu Ala Thr Gly Val Leu Lys 180 185 190 Pro Glu Thr Lys Pro Ala Thr Leu Asp Leu Pro Pro Pro Gln Pro Ser 195 200 205 Arg Pro Ser Thr Val Ala Lys Pro Leu Pro Pro Val Ala Val Ala Arg 210 215 220 Ala Arg Pro Gly Gly Thr Ala Arg Pro His Ala Asn Trp Gln Ser Thr 225 230 235 240 Leu Asn Ser Ile Val Gly Leu Gly Val Gln Ser Val Lys Arg Arg Arg 245 250 255 Cys Tyr <210> 172 <211> 937 <212> PRT <213> Simian adenovirus 26 <400> 172 Met Ala Thr Pro Ser Met Leu Pro Gln Trp Ala Tyr Met His Ile Ala 1 5 10 15 Gly Gln Asp Ala Ser Glu Tyr Leu Ser Pro Gly Leu Val Gln Phe Ala 20 25 30 Arg Ala Thr Asp Thr Tyr Phe Ser Leu Gly Asn Lys Phe Arg Asn Pro 35 40 45 Thr Val Ala Pro Thr His Asp Val Thr Thr Asp Arg Ser Gln Arg Leu 50 55 60 Thr Leu Arg Phe Val Pro Val Asp Arg Glu Asp Asn Thr Tyr Ser Tyr 65 70 75 80 Lys Val Arg Tyr Thr Leu Ala Val Gly Asp Asn Arg Val Leu Asp Met 85 90 95 Ala Ser Thr Tyr Phe Asp Ile Arg Gly Val Leu Asp Arg Gly Pro Ser 100 105 110 Phe Lys Pro Tyr Ser Gly Thr Ala Tyr Asn Ser Leu Ala Pro Lys Gly 115 120 125 Ala Pro Asn Thr Ser Gln Trp Val Thr Lys Asp Asn Gly Thr Asp Lys 130 135 140 Thr Tyr Ser Phe Gly Asn Ala Pro Val Arg Gly Leu Asp Ile Thr Glu 145 150 155 160 Glu Gly Leu Gln Ile Gly Thr Asp Asp Ser Ser Thr Glu Ser Lys Lys 165 170 175 Ile Phe Ala Asp Lys Thr Tyr Gln Pro Glu Pro Gln Val Gly Asp Glu 180 185 190 Glu Trp His Asp Thr Ile Gly Ala Glu Asp Lys Tyr Gly Gly Arg Ala 195 200 205 Leu Lys Pro Ala Thr Asn Met Lys Pro Cys Tyr Gly Ser Phe Ala Lys 210 215 220 Pro Thr Asn Ala Lys Gly Gly Gln Ala Lys Thr Arg Thr Lys Asp Asp 225 230 235 240 Gly Thr Thr Glu Pro Asp Ile Asp Met Ala Phe Phe Asp Asp Arg Ser 245 250 255 Gln Gln Ala Ser Phe Ser Pro Glu Leu Val Leu Tyr Thr Glu Asn Val 260 265 270 Asp Leu Glu Thr Pro Asp Thr His Ile Ile Tyr Lys Pro Gly Thr Asp 275 280 285 Glu Thr Ser Ser Ser Phe Asn Leu Gly Gln Gln Ser Met Pro Asn Arg 290 295 300 Pro Asn Tyr Ile Gly Phe Arg Asp Asn Phe Ile Gly Leu Met Tyr Tyr 305 310 315 320 Asn Ser Thr Gly Asn Met Gly Val Leu Ala Gly Gln Ala Ser Gln Leu 325 330 335 Asn Ala Val Val Asp Leu Gln Asp Arg Asn Thr Glu Leu Ser Tyr Gln 340 345 350 Leu Leu Leu Asp Ser Leu Gly Asp Arg Thr Arg Tyr Phe Ser Met Trp 355 360 365 Asn Gln Ala Val Asp Ser Tyr Asp Pro Asp Val Arg Ile Ile Glu Asn 370 375 380 His Gly Val Glu Asp Glu Leu Pro Asn Tyr Cys Phe Pro Leu Asn Gly 385 390 395 400 Val Gly Phe Thr Asp Thr Phe Gln Gly Ile Lys Val Lys Thr Thr Asn 405 410 415 Asn Gly Thr Ala Asn Ala Thr Glu Trp Glu Ser Asp Thr Ser Val Asn 420 425 430 Asn Ala Asn Glu Ile Ala Lys Gly Asn Pro Phe Ala Met Glu Ile Asn 435 440 445 Ile Gln Ala Asn Leu Trp Arg Asn Phe Leu Tyr Ala Asn Val Ala Leu 450 455 460 Tyr Leu Pro Asp Ser Tyr Lys Tyr Thr Pro Ala Asn Val Thr Leu Pro 465 470 475 480 Thr Asn Ile Asn Thr Tyr Asp Tyr Met Asn Gly Arg Val Val Ala Pro 485 490 495 Ser Leu Val Asp Ser Tyr Ile Asn Ile Gly Ala Arg Trp Ser Leu Asp 500 505 510 Pro Met Asp Asn Val Asn Pro Phe Asn His His Arg Asn Ala Gly Leu 515 520 525 Arg Tyr Arg Ser Met Leu Leu Gly Asn Gly Arg Tyr Val Pro Phe His 530 535 540 Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Ser Leu Leu Leu Leu 545 550 555 560 Pro Gly Ser Tyr Thr Tyr Glu Trp Asn Phe Arg Lys Asp Val Asn Met 565 570 575 Ile Leu Gln Ser Ser Leu Gly Asn Asp Leu Arg Thr Asp Gly Ala Ser 580 585 590 Ile Ser Phe Thr Ser Ile Asn Leu Tyr Ala Thr Phe Phe Pro Met Ala 595 600 605 His Asn Thr Ala Ser Thr Leu Glu Ala Met Leu Arg Asn Asp Thr Asn 610 615 620 Asp Gln Ser Phe Asn Asp Tyr Leu Ser Ala Ala Asn Met Leu Tyr Pro 625 630 635 640 Ile Pro Ala Asn Ala Thr Asn Val Pro Ile Ser Ile Pro Ser Arg Asn 645 650 655 Trp Ala Ala Phe Arg Gly Trp Ser Phe Thr Arg Leu Lys Thr Lys Glu 660 665 670 Thr Pro Ser Leu Gly Ser Gly Phe Asp Pro Tyr Phe Val Tyr Ser Gly 675 680 685 Ser Ile Pro Tyr Leu Asp Gly Thr Phe Tyr Leu Asn His Thr Phe Lys 690 695 700 Lys Val Ser Ile Thr Phe Asp Ser Ser Val Ser Trp Pro Gly Asn Asp 705 710 715 720 Arg Leu Leu Thr Pro Asn Glu Phe Glu Ile Lys Arg Thr Val Asp Gly 725 730 735 Glu Gly Tyr Asn Val Ala Gln Cys Asn Met Thr Lys Asp Trp Phe Leu 740 745 750 Val Gln Met Leu Ala His Tyr Asn Ile Gly Tyr Gln Gly Phe Tyr Val 755 760 765 Pro Glu Gly Tyr Lys Asp Arg Met Tyr Ser Phe Phe Arg Asn Phe Gln 770 775 780 Pro Met Ser Arg Gln Val Val Asp Glu Val Asn Tyr Lys Asp Tyr Gln 785 790 795 800 Ala Val Thr Leu Ala Tyr Gln His Asn Asn Ser Gly Phe Val Gly Tyr 805 810 815 Leu Ala Pro Thr Met Arg Gln Gly Gln Pro Tyr Pro Ala Asn Tyr Pro 820 825 830 Tyr Pro Leu Ile Gly Lys Ser Ala Val Thr Ser Val Thr Gln Lys Lys 835 840 845 Phe Leu Cys Asp Arg Val Met Trp Arg Ile Pro Phe Ser Ser Asn Phe 850 855 860 Met Ser Met Gly Ala Leu Thr Asp Leu Gly Gln Asn Met Leu Tyr Ala 865 870 875 880 Asn Ser Ala His Ala Leu Asp Met Asn Phe Glu Val Asp Pro Met Asp 885 890 895 Glu Ser Thr Leu Leu Tyr Val Val Phe Glu Val Phe Asp Val Val Arg 900 905 910 Val His Gln Pro His Arg Gly Val Ile Glu Ala Val Tyr Leu Arg Thr 915 920 925 Pro Phe Ser Ala Gly Asn Ala Thr Thr 930 935 <210> 173 <211> 209 <212> PRT <213> Simian adenovirus 26 <400> 173 Met Ala Glu Pro Thr Gly Ser Gly Glu Gln Glu Leu Arg Ala Ile Ile 1 5 10 15 Arg Asp Leu Gly Cys Gly Pro Tyr Phe Leu Gly Thr Phe Asp Lys Arg 20 25 30 Phe Pro Gly Phe Met Ala Pro His Lys Leu Ala Cys Ala Ile Val Asn 35 40 45 Thr Ala Gly Arg Glu Thr Gly Gly Glu His Trp Leu Ala Phe Ala Trp 50 55 60 Asn Pro Arg Ser Asn Thr Cys Tyr Leu Phe Asp Pro Phe Gly Phe Ser 65 70 75 80 Asp Glu Arg Leu Lys Gln Ile Tyr Gln Phe Glu Tyr Glu Gly Leu Leu 85 90 95 Arg Arg Ser Ala Leu Ala Thr Glu Asp Arg Cys Val Thr Leu Glu Lys 100 105 110 Ser Thr Gln Thr Val Gln Gly Pro Arg Ser Ala Ala Cys Gly Leu Phe 115 120 125 Cys Cys Met Phe Leu His Ala Phe Val His Trp Pro Asp Arg Pro Met 130 135 140 Asp Lys Asn Pro Thr Met Asn Leu Leu Thr Gly Val Pro Asn Gly Met 145 150 155 160 Leu Gln Ser Pro Gln Val Glu Pro Thr Leu Arg Arg Asn Gln Glu Ala 165 170 175 Leu Tyr Arg Phe Leu Asn Ser His Ser Ala Tyr Phe Arg Ser His Arg 180 185 190 Ala Arg Ile Glu Lys Ala Thr Ala Phe Asp Arg Met Asn Asn Gln Asp 195 200 205 Met <210> 174 <211> 802 <212> PRT <213> Simian adenovirus 26 <400> 174 Met Glu Thr Gln Pro Ser Pro Thr Ser Pro Ser Ala Pro Thr Thr Ala 1 5 10 15 Asp Glu Lys Gln Gln Gln Gln Asn Glu Ser Leu Thr Ala Pro Pro Pro 20 25 30 Ser Pro Ala Ser Asp Ala Ala Ala Val Pro Asp Met Gln Glu Met Glu 35 40 45 Glu Ser Ile Glu Ile Asp Leu Gly Tyr Val Thr Pro Ala Glu His Glu 50 55 60 Glu Glu Leu Ala Val Arg Phe Gln Ser Ser Ser Gln Glu Asp Lys Glu 65 70 75 80 Gln Pro Glu Gln Glu Ala Glu Asn Glu Gln Ser Gln Thr Gly Leu Glu 85 90 95 His Gly Asp Tyr Leu His Leu Ser Gly Glu Glu Asp Ala Leu Ile Lys 100 105 110 His Leu Ala Arg Gln Ala Thr Ile Val Lys Asp Ala Leu Leu Asp Arg 115 120 125 Thr Glu Val Pro Leu Ser Val Glu Glu Leu Ser Arg Ala Tyr Glu Leu 130 135 140 Asn Leu Phe Ser Pro Arg Val Pro Pro Lys Arg Gln Pro Asn Gly Thr 145 150 155 160 Cys Glu Pro Asn Pro Arg Leu Asn Phe Tyr Pro Val Phe Ala Val Pro 165 170 175 Glu Ala Leu Ala Thr Tyr His Ile Phe Phe Lys Asn Gln Lys Ile Pro 180 185 190 Val Ser Cys Arg Ala Asn Arg Thr Arg Ala Asp Ala Leu Phe Asn Leu 195 200 205 Gly Pro Gly Ala Arg Leu Pro Asp Ile Ala Ser Leu Glu Glu Val Pro 210 215 220 Lys Ile Phe Glu Gly Leu Gly Ser Asp Glu Thr Arg Ala Ala Asn Ala 225 230 235 240 Leu Gln Gly Asn Glu Glu His Glu His His Ser Ala Leu Val Glu Leu 245 250 255 Glu Gly Asp Asn Ala Arg Leu Ala Val Leu Lys Arg Thr Val Glu Leu 260 265 270 Thr His Phe Ala Tyr Pro Ala Leu Asn Leu Pro Pro Lys Val Met Ser 275 280 285 Ala Val Met Asp Gln Val Leu Ile Lys Arg Ala Ser Pro Ile Ser Glu 290 295 300 Asp Glu Gly Met Gln Asp Ser Glu Glu Gly Lys Pro Val Val Ser Asp 305 310 315 320 Glu Gln Leu Ala Arg Trp Leu Gly Pro Asn Ala Thr Pro Gln Ser Leu 325 330 335 Glu Glu Arg Arg Lys Leu Met Met Ala Val Val Leu Val Thr Val Glu 340 345 350 Leu Glu Cys Leu Arg Arg Phe Phe Ala Asp Ala Glu Thr Leu Arg Lys 355 360 365 Val Glu Glu Asn Leu His Tyr Leu Phe Arg His Gly Phe Val Arg Gln 370 375 380 Ala Cys Lys Ile Ser Asn Val Glu Leu Thr Asn Leu Val Ser Tyr Met 385 390 395 400 Gly Ile Leu His Glu Asn Arg Leu Gly Gln Asn Val Leu His Thr Thr 405 410 415 Leu Arg Gly Glu Ala Arg Arg Asp Tyr Ile Arg Asp Cys Val Tyr Leu 420 425 430 Tyr Leu Cys His Thr Trp Gln Thr Gly Met Gly Val Trp Gln Gln Cys 435 440 445 Leu Glu Glu Gln Asn Leu Lys Glu Leu Cys Lys Leu Leu Gln Lys Asn 450 455 460 Leu Lys Gly Leu Trp Thr Gly Phe Asp Glu Arg Thr Thr Ala Ser Asp 465 470 475 480 Leu Ala Asp Leu Ile Phe Pro Glu Arg Leu Arg Leu Thr Leu Arg Asn 485 490 495 Gly Leu Pro Asp Phe Met Ser Gln Ser Met Leu Gln Asn Phe Arg Ser 500 505 510 Phe Ile Leu Glu Arg Ser Gly Ile Leu Pro Ala Thr Cys Ser Ala Leu 515 520 525 Pro Ser Asp Phe Val Pro Leu Thr Phe Arg Glu Cys Pro Pro Pro Leu 530 535 540 Trp Ser His Cys Tyr Leu Leu Arg Leu Ala Asn Tyr Leu Ala Tyr His 545 550 555 560 Ser Asp Val Ile Glu Asp Val Ser Gly Glu Ala Leu Leu Glu Cys His 565 570 575 Cys Arg Cys Asn Leu Cys Thr Pro His Arg Ser Leu Ala Cys Asn Pro 580 585 590 Gln Leu Leu Ser Glu Thr Gln Ile Ile Gly Thr Phe Glu Leu Gln Gly 595 600 605 Pro Ser Glu Gly Glu Gly Ser Ala Ala Lys Gly Gly Leu Lys Leu Thr 610 615 620 Pro Gly Leu Trp Thr Ser Ala Tyr Leu Arg Lys Phe Val Pro Glu Asp 625 630 635 640 Tyr His Pro Phe Glu Ile Arg Phe Tyr Glu Asp Gln Ser Gln Pro Pro 645 650 655 Lys Ala Glu Leu Ser Ala Cys Val Ile Thr Gln Gly Ala Ile Leu Ala 660 665 670 Gln Leu Gln Ala Ile Gln Lys Ser Arg Gln Glu Phe Leu Leu Lys Lys 675 680 685 Gly Arg Gly Val Tyr Leu Asp Pro Gln Thr Gly Glu Glu Leu Asn Pro 690 695 700 Gly Phe Pro Gln Asp Ala Pro Arg Lys Gln Glu Ala Glu Ser Gly Ala 705 710 715 720 Ala Ala Arg Gly Gly Phe Gly Gly Arg Leu Gly Glu Gln Gln Ser Gly 725 730 735 Arg Gly Asp Gly Gly Arg Leu Gly Gln His Ser Gly Arg Gly Gly Gln 740 745 750 Pro Ala Arg Gln Ser Gly Gly Arg Arg Gly Gly Gly Arg Gly Gly Gly 755 760 765 Gly Arg Ser Ser Arg Arg Gln Thr Val Val Leu Gly Gly Gly Glu Ser 770 775 780 Lys Gln His Gly Tyr His Leu Arg Ser Gly Ser Gly Ser Arg Ser Ala 785 790 795 800 Pro Gln <210> 175 <211> 227 <212> PRT <213> Simian adenovirus 26 <400> 175 Met Ser Lys Glu Ile Pro Thr Pro Tyr Met Trp Ser Tyr Gln Pro Gln 1 5 10 15 Met Gly Leu Ala Ala Gly Ala Ala Gln Asp Tyr Ser Thr Arg Met Asn 20 25 30 Trp Leu Ser Ala Gly Pro Ala Met Ile Ser Arg Val Asn Asp Ile Arg 35 40 45 Ala His Arg Asn Gln Ile Leu Leu Glu Gln Ser Ala Leu Thr Ala Thr 50 55 60 Pro Arg Asn His Leu Asn Pro Arg Asn Trp Pro Ala Ala Leu Val Tyr 65 70 75 80 Gln Glu Ile Pro Gln Pro Thr Thr Val Leu Leu Pro Arg Asp Ala Gln 85 90 95 Ala Glu Val Gln Leu Thr Asn Ser Gly Val Gln Leu Ala Gly Gly Ala 100 105 110 Thr Leu Cys Arg His Arg Pro Ala Gln Gly Ile Lys Arg Leu Val Ile 115 120 125 Arg Gly Arg Gly Thr Gln Leu Asn Asp Glu Val Val Ser Ser Ser Leu 130 135 140 Gly Leu Arg Pro Asp Gly Val Phe Gln Leu Ala Gly Ser Gly Arg Ser 145 150 155 160 Ser Phe Thr Pro Arg Gln Ala Val Leu Thr Leu Glu Ser Ser Ser Ser 165 170 175 Gln Pro Arg Ser Gly Gly Ile Gly Thr Leu Gln Phe Val Glu Glu Phe 180 185 190 Thr Pro Ser Val Tyr Phe Asn Pro Phe Ser Gly Ser Pro Gly His Tyr 195 200 205 Pro Asp Glu Phe Ile Pro Asn Phe Asp Ala Ile Ser Glu Ser Val Asp 210 215 220 Gly Tyr Asp 225 <210> 176 <211> 106 <212> PRT <213> Simian adenovirus 26 <400> 176 Met Ser His Gly Gly Ala Ala Asp Leu Ala Arg Leu Arg His Leu Asp 1 5 10 15 His Cys Arg Arg Phe Arg Cys Phe Ala Arg Asp Leu Ala Glu Phe Thr 20 25 30 Tyr Phe Glu Leu Pro Glu Glu His Pro Gln Gly Pro Ala His Gly Val 35 40 45 Arg Ile Val Val Glu Gly Gly Leu Asp Ser His Leu Leu Arg Ile Phe 50 55 60 Ser Gln Arg Pro Ile Leu Val Glu Arg Gln Gln Gly Asn Thr Leu Leu 65 70 75 80 Thr Leu Tyr Cys Ile Cys Asp His Pro Gly Leu His Glu Ser Leu Cys 85 90 95 Cys Leu Leu Cys Thr Glu Tyr Asn Lys Ser 100 105 <210> 177 <211> 176 <212> PRT <213> Simian adenovirus 26 <400> 177 Met Gly Lys Ile Thr Leu Val Cys Gly Val Leu Val Thr Val Val Leu 1 5 10 15 Ser Ile Leu Gly Gly Gly Ser Ala Ala Val Val Thr Glu Lys Lys Ala 20 25 30 Asp Pro Cys Leu Thr Phe Asn Pro Asp Lys Cys Arg Leu Ser Phe Gln 35 40 45 Pro Asp Gly Asn Arg Cys Ala Val Leu Ile Lys Cys Gly Trp Glu Cys 50 55 60 Glu Ser Val Ala Ile Gln Tyr Lys Asn Lys Thr Arg Asn Asn Thr Leu 65 70 75 80 Ala Ser Thr Trp Gln Pro Gly Asp Pro Glu Trp Tyr Thr Val Ser Val 85 90 95 Pro Gly Ala Asp Gly Ser Leu Arg Thr Val Asn Asn Thr Phe Ile Phe 100 105 110 Glu His Met Cys Asp Thr Ala Met Phe Met Ser Lys Gln Tyr Gly Met 115 120 125 Trp Pro Pro Arg Lys Glu Asn Ile Val Val Phe Ser Ile Ala Tyr Ser 130 135 140 Ala Cys Thr Val Leu Ile Thr Ala Ile Val Cys Leu Ser Ile His Met 145 150 155 160 Leu Ile Ala Ile Arg Pro Arg Asn Asn Ala Glu Lys Glu Lys Gln Pro 165 170 175 <210> 178 <211> 246 <212> PRT <213> Simian adenovirus 26 <400> 178 Met Ala Ser Val Thr Ile Leu Ile Tyr Phe Leu Gly Leu Val Gly Thr 1 5 10 15 Ile Ser Ser Phe Asp His Lys Asn Val Thr Ala Tyr Val Gly Ser Asn 20 25 30 Cys Val Leu Ser Gly Tyr Gln Ser His Gln Arg Val Ser Trp Tyr Trp 35 40 45 Phe Asp Lys Lys Asn Thr Ala Tyr Thr Leu Cys Lys Gly Tyr Gln Gln 50 55 60 Pro Thr His Arg Ser Gly Leu Tyr Tyr Ser Cys Thr Asn Asn Asn Ile 65 70 75 80 Thr Leu Leu Gln Val Thr Asn Gln Tyr Ser Gly Thr Tyr Tyr Gly Thr 85 90 95 Asn Phe Asn Thr Lys Gln Asp Thr Tyr Tyr Ser Val Arg Val Leu Asp 100 105 110 Pro Thr Thr Pro Arg Thr Thr Thr Lys His Thr Thr Thr Lys Lys Pro 115 120 125 Thr Thr Pro Lys Lys Pro Thr Thr Pro Lys Thr Thr Lys Thr Thr Thr 130 135 140 Ala Lys Gln Thr Thr Thr Thr Glu Pro Thr Thr Thr Ser Thr Thr Leu 145 150 155 160 Ala Ile Thr Thr His Thr Glu Leu Thr Ser Gln Ala Thr Thr Glu Asn 165 170 175 Gly Phe Ala Leu Leu Gln Lys Gly Glu Asn Ser Ser Ser Ser Pro Leu 180 185 190 Pro Thr Thr Pro Ser Glu Glu Ile Pro Lys Ser Met Val Gly Ile Ile 195 200 205 Ala Ala Val Val Val Cys Met Val Ile Ile Ile Leu Cys Met Met Tyr 210 215 220 Tyr Ala Cys Tyr Tyr Arg Lys His Arg Leu Asn Asn Lys Leu Asp Pro 225 230 235 240 Leu Leu Asn Val Asp Phe 245 <210> 179 <211> 206 <212> PRT <213> Simian adenovirus 26 <400> 179 Met Lys Ile Leu Ser Leu Phe Val Phe Ser Ile Ile Thr Ser Ala Ile 1 5 10 15 Cys Lys Ser Val Asp Lys Asp Val Thr Val Thr Thr Gly Ser Asn Tyr 20 25 30 Thr Leu Lys Gly Pro Ser Ser Gly Met Leu Ser Trp Tyr Cys Tyr Phe 35 40 45 Gly Asn Asp Asp Lys Gln Thr Glu Leu Cys Asn Phe Gln Asn Gly Lys 50 55 60 Thr Lys Asn Ser Lys Ile Asp Asn Tyr Gln Cys His Gly Thr Asp Leu 65 70 75 80 Val Leu Met Asn Ile Thr Lys Ala Tyr Ala Gly Ser Tyr Ser Cys Pro 85 90 95 Gly Gln Asn Thr Glu Glu Met Ile Phe Tyr Lys Leu Ile Val Val Asp 100 105 110 Pro Thr Thr Pro Pro Pro Thr Thr Thr Thr Asn Ala Pro Thr Thr Asp 115 120 125 Thr Gln Glu Thr Thr Pro Glu Ala Val Ala Glu Leu Ala Lys Gln Ile 130 135 140 His Glu Asp Ser Phe Val Ala Asn Thr Pro Thr His Pro Gly Pro Gln 145 150 155 160 Cys Pro Gly Leu Val Val Ser Gly Ile Val Gly Val Leu Cys Gly Leu 165 170 175 Ala Val Ile Ile Ile Cys Met Phe Ile Phe Ala Cys Cys Tyr Arg Arg 180 185 190 Leu His Arg Gln Lys Ser Asp Pro Leu Leu Asn Leu Tyr Val 195 200 205 <210> 180 <211> 291 <212> PRT <213> Simian adenovirus 26 <400> 180 Met Lys Ala Leu Ser Thr Leu Val Phe Leu Ser Leu Ile Gly Ile Val 1 5 10 15 Phe Ser Ala Gly Phe Leu Lys Asn Leu Thr Ile Ile Glu Gly Asp Asn 20 25 30 Ala Thr Leu Val Gly Ile Ser Gly Gln Asn Val Ser Trp Leu Lys Tyr 35 40 45 His Leu Asp Gly Trp Lys Pro Ile Cys Thr Trp Asn Val Ser Val Tyr 50 55 60 Thr Cys His Gly Val Asn Leu Thr Ile Thr Asn Ala Thr Gln Asp Gln 65 70 75 80 Asn Gly Arg Phe Lys Gly Gln Ser Phe Thr Ser Asn Asn Gly Tyr Glu 85 90 95 Thr His Asn Met Phe Ile Tyr Asp Val Thr Val Ile Ser Asn Lys Thr 100 105 110 Thr Pro Thr Thr Gln Thr Pro Thr Thr His Ser Ser Thr His Ala Met 115 120 125 Gln Thr Thr Gln Thr Thr Thr Tyr Thr Thr Ser Ile Gln Pro Thr Thr 130 135 140 Thr Thr Ala Glu Val Thr Ser Thr Ala Pro Gln Pro Gln Ala Leu Ala 145 150 155 160 Leu Met Ala Ala Gln Pro Ser Ser Met Thr Ala Lys Thr Asn Glu Gln 165 170 175 Thr Thr Glu Phe Leu Ser Thr Thr Gln Ser Ser Thr Thr Ala Thr Ser 180 185 190 Ser Ala Phe Ser Ser Thr Ala Asn Leu Thr Ser Leu Ser Ser Thr Pro 195 200 205 Ile Ser Asn Ala Thr Thr Ser Pro Ala Pro Leu Pro Thr Pro Leu Lys 210 215 220 Gln Ser Glu Ser Ser Thr Gln Leu Gln Ile Thr Leu Leu Ile Val Ile 225 230 235 240 Gly Val Val Ile Leu Ala Val Leu Leu Tyr Phe Ile Phe Cys Arg Arg 245 250 255 Ile Pro Asn Ala Lys Pro Ala Tyr Lys Pro Ile Val Ile Gly Thr Pro 260 265 270 Glu Pro Leu Gln Val Glu Gly Gly Leu Arg Asn Leu Leu Phe Ser Phe 275 280 285 Thr Val Trp 290 <210> 181 <211> 91 <212> PRT <213> Simian adenovirus 26 <400> 181 Met Ile Pro Arg His Phe Ile Ile Thr Ser Leu Ile Cys Val Leu Gln 1 5 10 15 Val Cys Ala Thr Leu Ala Leu Val Ala Asn Ala Ser Pro Asp Cys Ile 20 25 30 Gly Ala Phe Ala Ser Tyr Val Leu Phe Ala Phe Ile Thr Cys Ile Cys 35 40 45 Cys Cys Ser Ile Val Cys Leu Leu Ile Thr Phe Phe Gln Phe Val Asp 50 55 60 Trp Val Phe Val Arg Ile Ala Tyr Leu Arg His His Pro Gln Tyr Arg 65 70 75 80 Asp Gln Arg Val Ala Gln Leu Leu Arg Leu Ile 85 90 <210> 182 <211> 148 <212> PRT <213> Simian adenovirus 26 <400> 182 Met Ile Ser Met Arg Ala Leu Leu Leu Leu Leu Ala Leu Leu Leu Val 1 5 10 15 Pro Leu Ala Ala Pro Leu Ser Phe Lys Ser Pro Thr Gln Ser Pro Glu 20 25 30 Glu Val Arg Lys Cys Lys Phe Gln Glu Pro Trp Lys Phe Leu Ser Cys 35 40 45 Tyr Lys Leu Lys Ser Glu Met His Pro Ser Trp Ile Met Ile Ile Gly 50 55 60 Ile Val Asn Ile Leu Ala Cys Thr Leu Phe Ser Phe Val Ile Tyr Pro 65 70 75 80 Arg Phe Asp Phe Gly Trp Asn Ala Pro Glu Ala Leu Trp Leu Pro Pro 85 90 95 Asp Pro Asp Ile Pro Pro Gln Gln Gln Gln Asn Gln Ala His Ala Pro 100 105 110 Pro Pro Gln Pro Arg Pro Gln Tyr Met Pro Ile Leu Asp Tyr Glu Ala 115 120 125 Glu Pro Gln Arg Ala Met Leu Pro Ala Ile Ser Tyr Phe Asn Leu Thr 130 135 140 Gly Gly Asp Asp 145 <210> 183 <211> 425 <212> PRT <213> Simian adenovirus 26 <400> 183 Met Ser Lys Lys Arg Ala Arg Val Asp Asp Gly Phe Asp Pro Val Tyr 1 5 10 15 Pro Tyr Asp Ala Asp Asn Ala Pro Thr Val Pro Phe Ile Asn Pro Pro 20 25 30 Phe Val Ser Ser Asp Gly Phe Gln Glu Lys Pro Leu Gly Val Leu Ser 35 40 45 Leu Arg Leu Ala Asp Pro Val Thr Thr Lys Asn Gly Ala Val Thr Leu 50 55 60 Lys Leu Gly Glu Gly Val Asp Leu Asp Asp Ser Gly Lys Leu Ile Ala 65 70 75 80 Asn Thr Val Ser Lys Ala Ile Ala Pro Leu Ser Phe Ser Asn Asn Thr 85 90 95 Ile Ser Leu Asn Met Asp Thr Pro Leu Tyr Thr Lys Asp Gly Lys Leu 100 105 110 Ser Leu Gln Val Ser Pro Pro Leu Asn Ile Leu Arg Ser Thr Ile Leu 115 120 125 Asn Thr Leu Ala Leu Ala Phe Gly Ser Gly Leu Gly Leu Ser Gly Ser 130 135 140 Ala Leu Ala Val Gln Leu Ala Ser Pro Leu Thr Phe Asp Asp Lys Gly 145 150 155 160 Asn Ile Lys Ile Thr Leu Asp Arg Gly Leu His Val Thr Thr Gly Asn 165 170 175 Ala Ile Glu Ser Asn Ile Ser Trp Ala Lys Gly Ile Lys Phe Glu Asp 180 185 190 Gly Ala Ile Ala Ala Asn Ile Gly Lys Gly Leu Glu Phe Gly Thr Ser 195 200 205 Ser Thr Val Thr Gly Val Asp Asp Ala Tyr Pro Ile Gln Val Lys Leu 210 215 220 Gly Ser Gly Leu Ser Phe Asp Ser Thr Gly Ala Ile Met Ala Gly Asn 225 230 235 240 Lys Glu Asp Asp Lys Leu Thr Leu Trp Thr Thr Pro Asp Pro Ser Pro 245 250 255 Asn Cys Gln Ile Leu Ala Glu Asn Asp Ala Lys Leu Thr Leu Cys Leu 260 265 270 Thr Lys Cys Gly Ser Gln Ile Leu Ala Thr Val Ser Val Leu Val Val 275 280 285 Gly Ser Gly Lys Leu Asn Pro Ile Thr Gly Glu Val Ser Ser Ala Gln 290 295 300 Val Phe Leu Arg Phe Asp Ser Asn Gly Val Leu Leu Val Asn Ser Ser 305 310 315 320 Thr Leu Lys Lys Tyr Trp Gly Tyr Arg Gln Gly Asp Ser Ile Asp Gly 325 330 335 Thr Pro Tyr Thr Asn Ala Val Gly Phe Met Pro Asn Leu Lys Ala Tyr 340 345 350 Pro Lys Ser Gln Ser Ser Thr Thr Lys Asn Asn Ile Val Gly Gln Val 355 360 365 Tyr Met Asn Gly Asp Asn Ser Lys Pro Met Leu Leu Thr Ile Thr Leu 370 375 380 Asn Gly Thr Asp Asp Thr Thr Ser Ala Tyr Ser Met Ser Phe Ser Tyr 385 390 395 400 Thr Trp Thr Asn Gly Ser Tyr Thr Gly Ala Thr Phe Gly Ala Asn Ser 405 410 415 Tyr Thr Phe Ser Tyr Ile Ala Gln Glu 420 425 <210> 184 <211> 570 <212> DNA <213> Simian adenovirus 26 <220> <221> CDS <222> (3)..(563) <223> label=Elb\19K <400> 184 gc atg gag att tgg acg gtc ttg gaa gac ttt cac aag act aga cag 47 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Lys Thr Arg Gln 1 5 10 15 ctg cta gag aac gcc tcg aac gga gtc tct tac ctg tgg aga ttc tgc 95 Leu Leu Glu Asn Ala Ser Asn Gly Val Ser Tyr Leu Trp Arg Phe Cys 20 25 30 ttc ggt ggc gac cta gct agg cta gtc tat agg gcc aaa cag gat tat 143 Phe Gly Gly Asp Leu Ala Arg Leu Val Tyr Arg Ala Lys Gln Asp Tyr 35 40 45 agt gaa caa ttt gag gtt att ttg aga gag tgt tct ggt ctt ttt gac 191 Ser Glu Gln Phe Glu Val Ile Leu Arg Glu Cys Ser Gly Leu Phe Asp 50 55 60 gct ctt aac ttg ggc cat cag tct cac ttt aac cag agg att tcg aga 239 Ala Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Arg Ile Ser Arg 65 70 75 gcc ctt gac ttt act act cct ggc aga acc act gcg gca gta gcc ttt 287 Ala Leu Asp Phe Thr Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe 80 85 90 95 ttt gct ttt ctt ctt gac aaa tgg agt caa gaa acc cat ttc agc agg 335 Phe Ala Phe Leu Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg 100 105 110 gat tac cag ctg gat ttc tta gca gta gct ttg tgg aga aca tgg aag 383 Asp Tyr Gln Leu Asp Phe Leu Ala Val Ala Leu Trp Arg Thr Trp Lys 115 120 125 tgc cag cgc ctg aat gca atc tca ggc tac ttg ccg gta cag ccg cta 431 Cys Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Leu 130 135 140 gac act ctg agg atc ctg aat ctc cag gag agt ccc agg gca cac caa 479 Asp Thr Leu Arg Ile Leu Asn Leu Gln Glu Ser Pro Arg Ala His Gln 145 150 155 cgt cgc cag cag cag cag cgg cag cag gag gag gat caa gaa gag aac 527 Arg Arg Gln Gln Gln Gln Arg Gln Gln Glu Glu Asp Gln Glu Glu Asn 160 165 170 175 ccg aga gcc ggc ctg gac cct ccg gag gag gag gag tagctga 570 Pro Arg Ala Gly Leu Asp Pro Pro Glu Glu Glu Glu 180 185 <210> 185 <211> 187 <212> PRT <213> Simian adenovirus 26 <400> 185 Met Glu Ile Trp Thr Val Leu Glu Asp Phe His Lys Thr Arg Gln Leu 1 5 10 15 Leu Glu Asn Ala Ser Asn Gly Val Ser Tyr Leu Trp Arg Phe Cys Phe 20 25 30 Gly Gly Asp Leu Ala Arg Leu Val Tyr Arg Ala Lys Gln Asp Tyr Ser 35 40 45 Glu Gln Phe Glu Val Ile Leu Arg Glu Cys Ser Gly Leu Phe Asp Ala 50 55 60 Leu Asn Leu Gly His Gln Ser His Phe Asn Gln Arg Ile Ser Arg Ala 65 70 75 80 Leu Asp Phe Thr Thr Pro Gly Arg Thr Thr Ala Ala Val Ala Phe Phe 85 90 95 Ala Phe Leu Leu Asp Lys Trp Ser Gln Glu Thr His Phe Ser Arg Asp 100 105 110 Tyr Gln Leu Asp Phe Leu Ala Val Ala Leu Trp Arg Thr Trp Lys Cys 115 120 125 Gln Arg Leu Asn Ala Ile Ser Gly Tyr Leu Pro Val Gln Pro Leu Asp 130 135 140 Thr Leu Arg Ile Leu Asn Leu Gln Glu Ser Pro Arg Ala His Gln Arg 145 150 155 160 Arg Gln Gln Gln Gln Arg Gln Gln Glu Glu Asp Gln Glu Glu Asn Pro 165 170 175 Arg Ala Gly Leu Asp Pro Pro Glu Glu Glu Glu 180 185 <210> 186 <211> 6450 <212> DNA <213> Simian adenovirus 26 <220> <221> CDS <222> (4)..(564) <223> label=22K <220> <221> CDS <222> (1870)..(2502) <223> label=CR1-alpha <220> <221> CDS <222> (6039)..(6440) <223> label=E3/14.7K <400> 186 agg atg ccc cga gga aac aag aag ctg aaa gtg gag ctg ccg ccc gtg 48 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val 1 5 10 15 gag gat ttg gag gaa gac tgg gag aac agc agt cag gca gag gag atg 96 Glu Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Met 20 25 30 gag gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac 144 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 agt ctg gag gaa gac gag gag gag gca gag gag gag gtg gaa gaa gca 192 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Glu Glu Val Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg ggg gag aaa gca agc agc acg 240 Ala Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt ccc gct cgg ccc cac agt aga 288 Asp Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg 80 85 90 95 tgg gac gag acc ggg cga ttc ccg aac ccc acc acc cag acc ggt aag 336 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys 100 105 110 aag gag cgg cag gga tac aag tcc tgg cgg ggg cac aaa aac gcc atc 384 Lys Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile 115 120 125 gtc tcc tgc ttg cag gcc tgc ggg ggc aac atc tcc ttc acc cgg cgc 432 Val Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg 130 135 140 tac ctg ctc ttc cac cgc ggg gtg aac ttc ccc cgc aac atc ttg cat 480 Tyr Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His 145 150 155 tac tac cgt cac ctc cac agc ccc tac tac ttc caa gaa gag gca gca 528 Tyr Tyr Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala 160 165 170 175 gcg gca gaa aaa gac cag cag aaa acc agc agc tag aaaatccaca 574 Ala Ala Glu Lys Asp Gln Gln Lys Thr Ser Ser 180 185 gcggcggcag gtggactgag gatcgcggcg aacgagccgg cgcagacccg ggagctgagg 634 aaccggatct ttcccaccct ctatgccatc ttccagcaga gtcgggggca ggagcaggaa 694 ctgaaagtca agaaccgttc tctgcgctcg ctcacccgca gttgtctgta tcacaagagc 754 gaagaccaac ttcagcgcac tctcgaggac gccgaggctc tcttcaacaa gtactgcgcg 814 ctcactctta aagagtagcc cgcgcccgcc cagtcgcaga aaaaggcggg aattacgtca 874 cctgtgccct tcgccctagc cgcctccacc catcatcatg agcaaagaga ttcccacgcc 934 ttacatgtgg agctaccagc cccagatggg cctggccgcc ggcgccgccc aggactactc 994 cacccgcatg aattggctca gcgccgggcc cgcgatgatc tcacgggtga atgacatccg 1054 cgcccaccga aaccagatac tcctagaaca gtcagcgctc accgccacgc cccgcaatca 1114 cctcaatccg cgtaattggc ccgccgccct ggtgtaccag gaaattcccc agcccacgac 1174 cgtactactt ccgcgagacg cccaggccga agtccagctg actaactcag gtgtccagct 1234 ggcgggcggc gccaccctgt gtcgtcaccg ccccgctcag ggtataaagc ggctggtgat 1294 ccggggcaga ggcacacagc tcaacgacga ggtggtgagc tcttcgctgg gtctgcgacc 1354 tgacggagtc ttccaactcg ccggatcggg gagatcttcc ttcacgcctc gtcaggcggt 1414 cctgactttg gaaagttcgt cctcgcagcc ccgctcgggc ggcatcggca ctctccagtt 1474 cgtggaggag ttcactccct cggtctactt caaccccttc tccggctccc ccggccacta 1534 cccggacgag ttcatcccga actttgacgc catcagcgag tcggtggacg gctacgattg 1594 aatgtcccat ggtggcgcgg ctgacctagc tcggcttcga caccttgacc actgccgccg 1654 ctttcgctgc ttcgcacggg acctcgccga gttcacctac ttcgagctgc ccgaggagca 1714 tcctcagggc ccggcccacg gagtgcggat cgtcgtcgaa gggggcctag actcccacct 1774 gcttcggatc ttcagccagc gcccgatcct ggtcgagcgc caacagggca acaccctcct 1834 gaccctctac tgcatctgcg accaccccgg cctgc atg aaa gtc ttt gtt gtc 1887 Met Lys Val Phe Val Val 190 tgc tgt gta ctg agt ata ata aaa gct gag atc agc gac tac tcc gga 1935 Cys Cys Val Leu Ser Ile Ile Lys Ala Glu Ile Ser Asp Tyr Ser Gly 195 200 205 ctc aac tgt ggt gtt tct gca tcc atc aat cgg tca ctg acc ttc acc 1983 Leu Asn Cys Gly Val Ser Ala Ser Ile Asn Arg Ser Leu Thr Phe Thr 210 215 220 ggg aac gag acc gag ctc cag ctc cag tgt aag ccc cac aag aag tac 2031 Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys Lys Pro His Lys Lys Tyr 225 230 235 240 ctc acc tgg ctg tac cag ggc tcc ccg atc gcc gtt gtt aac cac tgc 2079 Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile Ala Val Val Asn His Cys 245 250 255 gac gac gac gga gtc ctg ctg aac ggc ccc gcc aac ctt act ttt tcc 2127 Asp Asp Asp Gly Val Leu Leu Asn Gly Pro Ala Asn Leu Thr Phe Ser 260 265 270 acc cgc aga agc aag ctc gag ctc ttc caa ccc ttc ctc ccc ggg acc 2175 Thr Arg Arg Ser Lys Leu Glu Leu Phe Gln Pro Phe Leu Pro Gly Thr 275 280 285 tat cag tgc atc tcg gga ccc tgc cat cac acc ttc cac ctg atc ccg 2223 Tyr Gln Cys Ile Ser Gly Pro Cys His His Thr Phe His Leu Ile Pro 290 295 300 aat acc acc tct tcc cca gcg ccg ctc ccc act aac aac caa act aac 2271 Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro Thr Asn Asn Gln Thr Asn 305 310 315 320 cac cac caa cgc tac cga cgc gac ctc gtt gaa tct aat acc acc cac 2319 His His Gln Arg Tyr Arg Arg Asp Leu Val Glu Ser Asn Thr Thr His 325 330 335 acc gga ggt gag ctc cga ggt cct gaa tcc tct ggg att tat tac ggc 2367 Thr Gly Gly Glu Leu Arg Gly Pro Glu Ser Ser Gly Ile Tyr Tyr Gly 340 345 350 ccc tgg gag gtg gtg ggg tta ata gct tta ggc tta gta gcg ggt ggg 2415 Pro Trp Glu Val Val Gly Leu Ile Ala Leu Gly Leu Val Ala Gly Gly 355 360 365 ctt ttg gct ctc tgc tac cta tac ctc cct tgc ttt tcc tac tta gtg 2463 Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro Cys Phe Ser Tyr Leu Val 370 375 380 gtg ctt tgt tgc tgg ttt aag aaa tgg gga aga tca ccc tagtgtgcgg 2512 Val Leu Cys Cys Trp Phe Lys Lys Trp Gly Arg Ser Pro 385 390 395 tgtgctggtg acggtggtgc tttcgattct gggaggggga agcgcggctg tagtgacgga 2572 gaagaaggcc gatccctgct tgactttcaa ccccgataaa tgccggctga gttttcagcc 2632 cgatggcaat cggtgcgcgg tgttgatcaa gtgcggatgg gaatgcgaga gtgtggcgat 2692 tcagtataaa aacaagacgc ggaacaatac tctcgcgtcc acatggcagc ccggggaccc 2752 cgagtggtac accgtctctg tccctggtgc tgacggctcc ctccgcacgg tgaacaacac 2812 tttcattttt gagcacatgt gcgataccgc catgttcatg agcaagcagt acggtatgtg 2872 gcccccacga aaagagaata tcgtggtctt ctccatcgct tacagcgcgt gcacggtgct 2932 aatcaccgcg atcgtgtgcc tgagcattca catgctcatc gctattcgcc ccagaaataa 2992 tgccgagaaa gagaaacagc cataacacac ttttttcaca cacctttttc agaccatggc 3052 ctctgttaca atccttattt attttttggg ccttgtgggc actatcagca gtttcgacca 3112 taaaaacgta actgcttatg ttggttctaa ctgtgtacta tctgggtacc agtcacatca 3172 gcgggtttca tggtactggt ttgataaaaa gaacacagct tatacactct gcaaaggcta 3232 tcagcagccc acacatcgca gtggtcttta ttacagctgc accaataata atatcacact 3292 acttcaagta accaaccaat attctgggac ctactatgga accaatttta acacaaaaca 3352 ggacacttac tatagtgtca gagtattgga tccaactact cccagaacta ctactaaaca 3412 taccacaact aagaagccca ctacacctaa aaagcctacc acgcccaaaa ccactaagac 3472 aacaactgct aagcagacca ctaccacaga gccaaccaca accagcacca cacttgctat 3532 aactacacac actgagctga cctcacaggc aactactgaa aatggttttg ccctattgca 3592 aaagggggag aacagtagca gcagtcctct gcctactacc cccagtgagg aaatacccaa 3652 gtccatggtt ggcattatcg ctgctgtagt ggtgtgtatg gtgattatca tcttgtgcat 3712 gatgtactat gcctgctact acagaaaaca caggctaaac aataagctgg accccctact 3772 gaatgttgat ttttaatttt ttagaaccat gaagatccta agcctttttg ttttttctat 3832 cattacctct gctatttgta aatcagtgga taaggacgtt actgtcacca ctggctctaa 3892 ttatacacta aaagggcctt cctcaggtat gctttcgtgg tattgttatt ttggaaatga 3952 tgataaacag acagagcttt gtaatttcca gaacggaaaa accaaaaatt ctaaaataga 4012 taactatcaa tgccatggta ctgatttagt actgatgaat atcacgaaag catatgctgg 4072 cagttattcc tgtcctggac aaaacaccga agaaatgatt ttttacaaat tgattgtggt 4132 tgatcccact acacctccac ccaccacaac taccaatgca cctaccacag acacacagga 4192 aaccactcca gaggcagtag cagagttagc aaagcagatt catgaagatt cctttgttgc 4252 taatactccc acacaccccg gaccgcaatg tccagggtta gtagtcagcg gcattgtcgg 4312 tgtgctttgc gggttagcag ttataatcat ctgcatgttc atttttgctt gctgctacag 4372 aaggcttcac cgacaaaaat cagacccact gctgaacctc tatgtttaat ttttgatttt 4432 ccagagccat gaaggcactt agcactttag tatttttgtc cttgattggc attgttttca 4492 gtgctgggtt tttgaaaaat cttaccatta ttgaaggcga taatgcaaca ctggtaggaa 4552 tcagtggtca gaatgttagt tggctaaaat atcatctaga tgggtggaaa cctatttgca 4612 cctggaatgt cagtgtgtac acatgtcatg gtgttaacct caccattacc aatgccaccc 4672 aagatcagaa tggcaggttt aagggtcaga gtttcactag caacaatggc tatgaaaccc 4732 ataacatgtt catctatgat gtcactgtca tatcaaataa gactacacct accacccaaa 4792 cacccactac acatagctca actcatgcca tgcagaccac tcagaccacc acttacacta 4852 catccattca gcccaccacc actacagcag aggtaaccag cacagcgcct cagccccaag 4912 cattggcttt gatggctgca cagcctagca gcatgactgc taaaaccaat gagcagacta 4972 ctgaattttt gtccactact cagagcagca ccacagctac ctcgagtgcc ttctctagca 5032 ccgccaatct cacctcgctt tcttctacgc caatcagtaa tgctactacc tcccccgctc 5092 ctcttcccac tcctctgaag caatccgagt ctagcacgca gctgcagatc accctgctca 5152 ttgtgatcgg ggtggtcatc ctggcagtgc tgctctactt tatcttctgc cgccgcatcc 5212 ccaacgcgaa accggcctac aagcccattg ttatcgggac gccggaaccg cttcaggtgg 5272 agggaggtct aaggaatctt ctcttctctt ttacagtatg gtgatttgaa ctatgattcc 5332 tagacatttc attatcactt ctctaatctg tgtgctccaa gtctgtgcca ccctcgctct 5392 cgtggctaac gcgagtccag actgcattgg agcgttcgcc tcctacgtgc tctttgcctt 5452 catcacctgc atctgctgct gtagcatagt ctgcctgctt atcaccttct tccagttcgt 5512 tgactgggtc tttgtgcgca tcgcctacct gcgccaccat ccccagtacc gcgaccagag 5572 agtggcgcaa ctgttgagac tcatctgatg ataagcatgc gggctctgct actactcctc 5632 gcgcttctgc tagttcccct cgccgccccc ttatccttca aatcccccac ccagtcccct 5692 gaagaggttc gaaaatgtaa attccaagaa ccctggaaat tcctttcatg ctacaaactc 5752 aaatcagaaa tgcaccccag ctggatcatg atcattggaa tcgtgaacat ccttgcctgt 5812 accctcttct cctttgtgat ttacccccgc tttgactttg ggtggaacgc acccgaggcg 5872 ctctggctcc cgcctgatcc cgacatacca ccacagcagc agcaaaatca ggcacacgca 5932 ccaccaccac agcctaggcc acaatacatg cccatcttag actatgaggc cgagccacag 5992 cgagccatgc ttcctgctat tagttacttc aacctaaccg gcggag atg act gac 6047 Met Thr Asp 400 ccc atg gcc aac aac acc gtc aac gac ctc ctg gac atg gac ggc cgc 6095 Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met Asp Gly Arg 405 410 415 gcc tcg gag cag cga ctc gcc caa ctc cgc atc cgc cag cag cag gag 6143 Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln Gln Gln Glu 420 425 430 aga gcc gtc aag gag ctg cag gat gcg gtg gct atc cac cag tgc aag 6191 Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His Gln Cys Lys 435 440 445 aga ggc atc ttc tgc ctg gtg aag cag gcc aag atc acc ttc gag gtg 6239 Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Thr Phe Glu Val 450 455 460 act tcc acc gac cat cgc ctc tcc tac gag ctc ctg cag cag cgc cag 6287 Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln Gln Arg Gln 465 470 475 480 aag ttc acc tgc ctg gtc gga gtc aac ccc atc gtc atc acc cag cag 6335 Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile Thr Gln Gln 485 490 495 tct ggc gat acc aag ggg tgc atc cac tgc tcc tgc gac tcc ccc gag 6383 Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp Ser Pro Glu 500 505 510 tgc ctt cac acc ctg gtc aag acc ctc tgc ggc ctc cgc gac ctc ctc 6431 Cys Leu His Thr Leu Val Lys Thr Leu Cys Gly Leu Arg Asp Leu Leu 515 520 525 ccc atg aac taatcaacta 6450 Pro Met Asn 530 <210> 187 <211> 186 <212> PRT <213> Simian adenovirus 26 <400> 187 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Met Glu 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Asp Glu Glu Glu Ala Glu Glu Glu Val Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Gly Lys Lys 100 105 110 Glu Arg Gln Gly Tyr Lys Ser Trp Arg Gly His Lys Asn Ala Ile Val 115 120 125 Ser Cys Leu Gln Ala Cys Gly Gly Asn Ile Ser Phe Thr Arg Arg Tyr 130 135 140 Leu Leu Phe His Arg Gly Val Asn Phe Pro Arg Asn Ile Leu His Tyr 145 150 155 160 Tyr Arg His Leu His Ser Pro Tyr Tyr Phe Gln Glu Glu Ala Ala Ala 165 170 175 Ala Glu Lys Asp Gln Gln Lys Thr Ser Ser 180 185 <210> 188 <211> 211 <212> PRT <213> Simian adenovirus 26 <400> 188 Met Lys Val Phe Val Val Cys Cys Val Leu Ser Ile Ile Lys Ala Glu 1 5 10 15 Ile Ser Asp Tyr Ser Gly Leu Asn Cys Gly Val Ser Ala Ser Ile Asn 20 25 30 Arg Ser Leu Thr Phe Thr Gly Asn Glu Thr Glu Leu Gln Leu Gln Cys 35 40 45 Lys Pro His Lys Lys Tyr Leu Thr Trp Leu Tyr Gln Gly Ser Pro Ile 50 55 60 Ala Val Val Asn His Cys Asp Asp Asp Gly Val Leu Leu Asn Gly Pro 65 70 75 80 Ala Asn Leu Thr Phe Ser Thr Arg Arg Ser Lys Leu Glu Leu Phe Gln 85 90 95 Pro Phe Leu Pro Gly Thr Tyr Gln Cys Ile Ser Gly Pro Cys His His 100 105 110 Thr Phe His Leu Ile Pro Asn Thr Thr Ser Ser Pro Ala Pro Leu Pro 115 120 125 Thr Asn Asn Gln Thr Asn His His Gln Arg Tyr Arg Arg Asp Leu Val 130 135 140 Glu Ser Asn Thr Thr His Thr Gly Gly Glu Leu Arg Gly Pro Glu Ser 145 150 155 160 Ser Gly Ile Tyr Tyr Gly Pro Trp Glu Val Val Gly Leu Ile Ala Leu 165 170 175 Gly Leu Val Ala Gly Gly Leu Leu Ala Leu Cys Tyr Leu Tyr Leu Pro 180 185 190 Cys Phe Ser Tyr Leu Val Val Leu Cys Cys Trp Phe Lys Lys Trp Gly 195 200 205 Arg Ser Pro 210 <210> 189 <211> 134 <212> PRT <213> Simian adenovirus 26 <400> 189 Met Thr Asp Pro Met Ala Asn Asn Thr Val Asn Asp Leu Leu Asp Met 1 5 10 15 Asp Gly Arg Ala Ser Glu Gln Arg Leu Ala Gln Leu Arg Ile Arg Gln 20 25 30 Gln Gln Glu Arg Ala Val Lys Glu Leu Gln Asp Ala Val Ala Ile His 35 40 45 Gln Cys Lys Arg Gly Ile Phe Cys Leu Val Lys Gln Ala Lys Ile Thr 50 55 60 Phe Glu Val Thr Ser Thr Asp His Arg Leu Ser Tyr Glu Leu Leu Gln 65 70 75 80 Gln Arg Gln Lys Phe Thr Cys Leu Val Gly Val Asn Pro Ile Val Ile 85 90 95 Thr Gln Gln Ser Gly Asp Thr Lys Gly Cys Ile His Cys Ser Cys Asp 100 105 110 Ser Pro Glu Cys Leu His Thr Leu Val Lys Thr Leu Cys Gly Leu Arg 115 120 125 Asp Leu Leu Pro Met Asn 130 <210> 190 <211> 880 <212> DNA <213> Simian adenovirus 26 <220> <221> CDS <222> (6)..(570) <223> label=Ela <220> <221> CDS <222> (666)..(871) <223> label=Ela <400> 190 gaaag atg agg cac ctg aga gac ctg ccc gat gag aaa atc atc atc gct 50 Met Arg His Leu Arg Asp Leu Pro Asp Glu Lys Ile Ile Ile Ala 1 5 10 15 tcc ggg aac gag att ctg gaa ctg gtg gta aat gcc atg atg ggc gac 98 Ser Gly Asn Glu Ile Leu Glu Leu Val Val Asn Ala Met Met Gly Asp 20 25 30 gac cct ccg gag ccc ccc acc cca ttt gag gca cct tcg ctg cac gat 146 Asp Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu His Asp 35 40 45 ttg tat gat ctg gag gtg gat gtg ccc gat gac gac ccc aac gag gag 194 Leu Tyr Asp Leu Glu Val Asp Val Pro Asp Asp Asp Pro Asn Glu Glu 50 55 60 gcg gta aat gat tta ttt agc gat gcc gcg ctg cta gct gcc gag gag 242 Ala Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Glu 65 70 75 gct tcg agc cct agc tca gac agc gac tct tca ctg cat acc cct aga 290 Ala Ser Ser Pro Ser Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg 80 85 90 95 cct ggc aga ggt gag aaa aag atc ccc gag ctt aaa ggg gaa gag atg 338 Pro Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Met 100 105 110 gac ttg cgc tgc tat gag gaa tgc ttg ccc ccg agc gat gat gag gac 386 Asp Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Asp 115 120 125 gag cag gcg atc cag aac gca gcg agc cag gga gtg caa gcc gcc agc 434 Glu Gln Ala Ile Gln Asn Ala Ala Ser Gln Gly Val Gln Ala Ala Ser 130 135 140 gag agc ttt gcg ctg gac tgc ccg cct ctg ccc gga cac ggc tgt aag 482 Glu Ser Phe Ala Leu Asp Cys Pro Pro Leu Pro Gly His Gly Cys Lys 145 150 155 tct tgt gaa ttt cat cgc atg aat act gga gat aaa gct gtg ttg tgt 530 Ser Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Ala Val Leu Cys 160 165 170 175 gca ctt tgc tat atg aga gct tac aac cat tgt gtt tac a gtaagtgtga 580 Ala Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr 180 185 ttaagttgaa ctttagaggg aggcagagag cagggtgact gggcgatgac tggtttattt 640 atgtatatat atgttcttta tatag gt ccc gtc tct gac gca gat gat gag 691 Ser Pro Val Ser Asp Ala Asp Asp Glu 190 195 acc ccc act aca gag tcc act tcg tca ccc cca gaa att ggc aca tct 739 Thr Pro Thr Thr Glu Ser Thr Ser Ser Pro Pro Glu Ile Gly Thr Ser 200 205 210 cca cct gag aat att gtt aga cca gtt cct gtt aga gcc act ggg agg 787 Pro Pro Glu Asn Ile Val Arg Pro Val Pro Val Arg Ala Thr Gly Arg 215 220 225 aga gca gct gtg gaa tgt ttg gat gac ttg cta cag ggt ggg gat gaa 835 Arg Ala Ala Val Glu Cys Leu Asp Asp Leu Leu Gln Gly Gly Asp Glu 230 235 240 245 cct ttg gac ttg tgt acc cgg aaa cgc ccc agg cac taagtgcca 880 Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg His 250 255 <210> 191 <211> 257 <212> PRT <213> Simian adenovirus 26 <400> 191 Met Arg His Leu Arg Asp Leu Pro Asp Glu Lys Ile Ile Ile Ala Ser 1 5 10 15 Gly Asn Glu Ile Leu Glu Leu Val Val Asn Ala Met Met Gly Asp Asp 20 25 30 Pro Pro Glu Pro Pro Thr Pro Phe Glu Ala Pro Ser Leu His Asp Leu 35 40 45 Tyr Asp Leu Glu Val Asp Val Pro Asp Asp Asp Pro Asn Glu Glu Ala 50 55 60 Val Asn Asp Leu Phe Ser Asp Ala Ala Leu Leu Ala Ala Glu Glu Ala 65 70 75 80 Ser Ser Pro Ser Ser Asp Ser Asp Ser Ser Leu His Thr Pro Arg Pro 85 90 95 Gly Arg Gly Glu Lys Lys Ile Pro Glu Leu Lys Gly Glu Glu Met Asp 100 105 110 Leu Arg Cys Tyr Glu Glu Cys Leu Pro Pro Ser Asp Asp Glu Asp Glu 115 120 125 Gln Ala Ile Gln Asn Ala Ala Ser Gln Gly Val Gln Ala Ala Ser Glu 130 135 140 Ser Phe Ala Leu Asp Cys Pro Pro Leu Pro Gly His Gly Cys Lys Ser 145 150 155 160 Cys Glu Phe His Arg Met Asn Thr Gly Asp Lys Ala Val Leu Cys Ala 165 170 175 Leu Cys Tyr Met Arg Ala Tyr Asn His Cys Val Tyr Ser Pro Val Ser 180 185 190 Asp Ala Asp Asp Glu Thr Pro Thr Thr Glu Ser Thr Ser Ser Pro Pro 195 200 205 Glu Ile Gly Thr Ser Pro Pro Glu Asn Ile Val Arg Pro Val Pro Val 210 215 220 Arg Ala Thr Gly Arg Arg Ala Ala Val Glu Cys Leu Asp Asp Leu Leu 225 230 235 240 Gln Gly Gly Asp Glu Pro Leu Asp Leu Cys Thr Arg Lys Arg Pro Arg 245 250 255 His <210> 192 <211> 830 <212> DNA <213> Simian adenovirus 26 <220> <221> CDS <222> (4)..(331) <223> label=33K <220> <221> CDS <222> (501)..(829) <223> label=33K <400> 192 agg atg ccc cga gga aac aag aag ctg aaa gtg gag ctg ccg ccc gtg 48 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val 1 5 10 15 gag gat ttg gag gaa gac tgg gag aac agc agt cag gca gag gag atg 96 Glu Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Met 20 25 30 gag gaa gac tgg gac agc act cag gca gag gag gac agc ctg caa gac 144 Glu Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp 35 40 45 agt ctg gag gaa gac gag gag gag gca gag gag gag gtg gaa gaa gca 192 Ser Leu Glu Glu Asp Glu Glu Glu Ala Glu Glu Glu Val Glu Glu Ala 50 55 60 gcc gcc gcc aga ccg tcg tcc tcg gcg ggg gag aaa gca agc agc acg 240 Ala Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr 65 70 75 gat acc atc tcc gct ccg ggt cgg ggt ccc gct cgg ccc cac agt aga 288 Asp Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg 80 85 90 95 tgg gac gag acc ggg cga ttc ccg aac ccc acc acc cag acc g 331 Trp Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr 100 105 gtaagaagga gcggcaggga tacaagtcct ggcgggggca caaaaacgcc atcgtctcct 391 gcttgcaggc ctgcgggggc aacatctcct tcacccggcg ctacctgctc ttccaccgcg 451 gggtgaactt cccccgcaac atcttgcatt actaccgtca cctccacag cc cct act 508 Ala Pro Thr act tcc aag aag agg cag cag cgg cag aaa aag acc agc aga aaa cca 556 Thr Ser Lys Lys Arg Gln Gln Arg Gln Lys Lys Thr Ser Arg Lys Pro 115 120 125 gca gct aga aaa tcc aca gcg gcg gca ggt gga ctg agg atc gcg gcg 604 Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile Ala Ala 130 135 140 aac gag ccg gcg cag acc cgg gag ctg agg aac cgg atc ttt ccc acc 652 Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe Pro Thr 145 150 155 160 ctc tat gcc atc ttc cag cag agt cgg ggg cag gag cag gaa ctg aaa 700 Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu Leu Lys 165 170 175 gtc aag aac cgt tct ctg cgc tcg ctc acc cgc agt tgt ctg tat cac 748 Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu Tyr His 180 185 190 aag agc gaa gac caa ctt cag cgc act ctc gag gac gcc gag gct ctc 796 Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu Ala Leu 195 200 205 ttc aac aag tac tgc gcg ctc act ctt aaa gag t 830 Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 <210> 193 <211> 219 <212> PRT <213> Simian adenovirus 26 <400> 193 Met Pro Arg Gly Asn Lys Lys Leu Lys Val Glu Leu Pro Pro Val Glu 1 5 10 15 Asp Leu Glu Glu Asp Trp Glu Asn Ser Ser Gln Ala Glu Glu Met Glu 20 25 30 Glu Asp Trp Asp Ser Thr Gln Ala Glu Glu Asp Ser Leu Gln Asp Ser 35 40 45 Leu Glu Glu Asp Glu Glu Glu Ala Glu Glu Glu Val Glu Glu Ala Ala 50 55 60 Ala Ala Arg Pro Ser Ser Ser Ala Gly Glu Lys Ala Ser Ser Thr Asp 65 70 75 80 Thr Ile Ser Ala Pro Gly Arg Gly Pro Ala Arg Pro His Ser Arg Trp 85 90 95 Asp Glu Thr Gly Arg Phe Pro Asn Pro Thr Thr Gln Thr Ala Pro Thr 100 105 110 Thr Ser Lys Lys Arg Gln Gln Arg Gln Lys Lys Thr Ser Arg Lys Pro 115 120 125 Ala Ala Arg Lys Ser Thr Ala Ala Ala Gly Gly Leu Arg Ile Ala Ala 130 135 140 Asn Glu Pro Ala Gln Thr Arg Glu Leu Arg Asn Arg Ile Phe Pro Thr 145 150 155 160 Leu Tyr Ala Ile Phe Gln Gln Ser Arg Gly Gln Glu Gln Glu Leu Lys 165 170 175 Val Lys Asn Arg Ser Leu Arg Ser Leu Thr Arg Ser Cys Leu Tyr His 180 185 190 Lys Ser Glu Asp Gln Leu Gln Arg Thr Leu Glu Asp Ala Glu Ala Leu 195 200 205 Phe Asn Lys Tyr Cys Ala Leu Thr Leu Lys Glu 210 215 <210> 194 <211> 65 <212> DNA <213> Artificial <220> <223> oligonucleotide SV39T <400> 194 aattatttaa atcccgggga tcatcgatga tctctagaga tcactagtct aggatatcat 60 ttaaa 65 <210> 195 <211> 63 <212> DNA <213> Artificial <220> <223> oligonucleotide SV39B <400> 195 tatttaaatg atatcctaga ctagtgatct ctagagatca tcgatgatcc ccgggattta 60 aat 63 <210> 196 <211> 46 <212> DNA <213> Artificial <220> <223> oligomer SV25 Top <400> 196 aattatttaa atcccgggta tcaagcttga tagatatcat ttaaat 46 <210> 197 <211> 44 <212> DNA <213> Artificial <220> <223> oligomer SV25 Bot <400> 197 taatttaaat gatatctatc aagcttgata cccgggattt aaat 44 <210> 198 <211> 58 <212> DNA <213> Artificial <220> <223> oligomer pSR6 top <400> 198 aattttaatt aacccgggta tcggcgcgcc ttaacctagg gatagatatc ttaattaa 58 <210> 199 <211> 56 <212> DNA <213> Artificial <220> <223> oligomer pSR6 bot <400> 199 tattaattaa gatatctatc cctaggttaa ggcgcgccga tacccgggtt aattaa 56 <210> 200 <211> 660 <212> DNA <213> Unknown <220> <223> Plasmid sequence <400> 200 gatatcattt ccccgaaaag tgccacctga cgtaactata acggtcctaa ggtagcgaaa 60 gctcagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg atgccgcata 120 gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt gcgcgagcaa 180 aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc tgcttagggt 240 taggcgtttt gcgctgcttc gcgatgtacg ggccagatat acgcggtacg aaaccgctga 300 tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct 360 tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca 420 tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag 480 ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct 540 gaggcggaaa gaaccagcag atctgcagat ctgaattcat ctatgtcggg tgcggagaaa 600 gaggtaatga aatggcatta tgggtattat gggtctgcat taatgaatcg gccagatatc 660

Claims (21)

  1. (a) SAdV-39의 헥손 단백질, SEQ ID NO: 11의 아미노산 1 내지 940; SAdV-30의 헥손 단백질, SEQ ID NO: 108의 아미노산 1 내지 938; SAdV-25.2의 헥손 단백질, SEQ ID NO: 140의 아미노산 1 내지 933; SAdV-37의 헥손 단백질, SEQ ID NO: 43의 아미노산 1 내지 942; SAdV-38의 헥손 단백질, SEQ ID NO: 75의 아미노산 1 내지 930; SAdV-26의 헥손 단백질, SEQ ID NO: 172의 아미노산 1 내지 937;
    (b) SAdV-39의 펜톤 단백질, SEQ ID NO: 6의 아미노산 1 내지 532; SAdV-30의 펜톤 단백질, SEQ ID NO: 103의 아미노산 1 내지 533; SAdV-25.2의 펜톤 단백질, SEQ ID NO: 135의 아미노산 1 내지 531; SAdV-37의 펜톤 단백질, SEQ ID NO: 38의 아미노산 1 내지 542; SAdV-38의 펜톤 단백질, SEQ ID NO: 70의 아미노산 1 내지 539; SAdV-26의 펜톤 단백질, SEQ ID NO: 167의 아미노산 1 내지 546; 및
    (c) SAdV-39의 섬유 단백질, SEQ ID NO: 22의 아미노산 1 내지 489, SAdV-30의 섬유 단백질, SEQ ID NO: 118의 아미노산 1 내지 445; SAdV-25.2의 섬유 단백질, SEQ ID NO: 151의 아미노산 1 내지 443; SAdV-37의 섬유 단백질, SEQ ID NO: 54의 아미노산 1 내지 445; SAdV-38의 섬유 단백질, SEQ ID NO: 85의 아미노산 1 내지 425; SAdV-26의 섬유 단백질, SEQ ID NO: 183의 아미노산 1 내지 425;
    로 구성되는 군으로부터 선택되는 캡시드 단백질을 포함하는 캡시드를 가지며,
    상기 캡시드는 숙주 세포에서 그것의 전사, 번역 및/또는 발현을 지시하는 발현 조절 서열에 작동가능하게 연결된 유전자를 전달하는 이종성 분자를 단백질막으로 싸는 아데노바이러스.
  2. 제 1 항에 있어서, 복제 및 단백질 막화에 필요한 5' 및 3' 아데노바이러스 시스-구성요소를 추가로 포함하는 것을 특징으로 하는 아데노바이러스.
  3. 제 1 항에 있어서, 상기 아데노바이러스는 E1 유전자의 모두 또는 일부를 결핍하는 것을 특징으로 하는 아데노바이러스.
  4. 제 3 항에 있어서, 상기 아데노바이러스는 복제-결함인 것을 특징으로 하는 아데노바이러스.
  5. 제 5 항에 있어서, 상기 바이러스는 하이브리드 캡시드인 것을 특징으로 하는 아데노바이러스.
  6. 제 5 항에 있어서, 상기 벡터는 SAdV-39, SAdV-30, SAdV-25.2, SAdV-37, SAdV-38, 및 SAdV-26으로부터 선택되는 하나 이상의 캡시드 단백질을 포함하는 것을 특징으로 하는 아데노바이러스.
  7. SAdV 헥손 단백질의 단편은 길이에 있어서 약 50개의 아미노산의 N-말단 또는 C-말단 절단을 가지는 SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 SAdV 헥손 단백질 또는
    SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 아미노산 잔기 125 내지 443;
    SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 아미노산 잔기 138 내지 441;
    SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 아미노산 잔기 138 내지 163;
    SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 아미노산 잔기 170 내지 176; 및
    SEQ ID NO: 11, 108, 140, 43, 75 또는 172의 아미노산 잔기 404 내지 430으로 구성되는 군으로부터 선택되는 유인원 아데노바이러스 헥손 단백질의 단편 및 SAdV에 이종성인 핵산 서열을 함유하는 헥손을 포함하는 캡시드를 가지는 재조합 아데노바이러스.
  8. 제 7 항에 있어서, 캡시드는 SAdV-39, SAdV-30, SAdV-25.2, SAdV-37, SAdV-38 또는 SAdV-26 섬유 단백질을 추가로 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  9. 제 7 항에 있어서, 캡시드는 추가로 SAdV-39, SAdV-30, SAdV-25.2, SAdV-37, SAdV-38 또는 SAdV-26 펜톤 단백질을 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  10. 제 7 항에 있어서, 상기 아데노바이러스는 복제 및 단백질 막화에 필요한 5' 및 3' 아데노바이러스 시스-구성요소를 포함하는 슈도타입화된 아데노바이러스이고, 상기 시스-구성요소는 아데노바이러스 5' 역위 말단 반복 및 아데노바이러스 3' 역위 말단 반복을 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  11. 제 7 항에 있어서, 아데노바이러스는 숙주 세포에서 생성물의 발현을 지시하는 서열에 작동가능하게 연결된 생성물을 암호화하는 핵산 서열을 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  12. 제 7 항에 있어서, 재조합 아데노바이러스는 하나 이상의 아데노바이러스 유전자를 포함하는 것을 특징으로 하는 재조합 아데노바이러스.
  13. 제 7 항에 있어서, 재조합 아데노바이러스는 복제-결함인 것을 특징으로 하는 재조합 아데노바이러스.
  14. 제 13 항에 있어서, 재조합 아데노바이러스는 아데노바이러스 E1에서 결실된 것을 특징으로 하는 재조합 아데노바이러스.
  15. 약학적으로 허용가능한 담체 중에 제 1 항 내지 제 14 항 중 어느 한 항의 바이러스를 포함하는 조성물.
  16. 제 1 항 내지 제 14 항 중 어느 한 항에 따르는 바이러스를 피험자에게 전달하는 단계를 포함하는 아데노바이러스 수용체를 가지는 세포를 표적화하는 방법.
  17. 유인원 아데노바이러스 39 핵산 SEQ ID NO:1의 1 내지 36553 및 그것의 보체;
    유인원 아데노바이러스 25.2 핵산 SEQ ID NO: 130의 1 내지 36629 및 그것의 보체;
    유인원 아데노바이러스 26 핵산 SEQ ID NO: 162의 1 내지 36628 및 그것의 보체;
    유인원 아데노바이러스 30 핵산 SEQ ID NO: 98의 1 내지 36621 및 그것의 보체;
    유인원 아데노바이러스 37 핵산 SEQ ID NO: 33의 1 내지 36634 및 그것의 보체; 및
    유인원 아데노바이러스 38 핵산 SEQ ID NO: 65의 1 내지 36494 및 그것의 보체
    로 구성되는 군으로부터 선택되는 분리된 유인원 아데노바이러스 핵산.
  18. (a) 5' 역위 말단 반복 (ITR) 서열;
    (b) 아데노바이러스 E1a 영역;
    (c) 아데노바이러스 E1b 영역, 또는 작은 T, 거대한 T, IX, 및 IVa2영역에 대한 오픈리딩프레임으로 구성되는 군 중에서 선택되는 그것의 단편;
    (d) pTP, 폴리머라아제, 및 IVa 영역에 대한 오픈리딩프레임을 포함하는 E2b 영역;
    (e) L1 영역, 또는 52/55 kD 단백질, 및 IIIa 단백질에 대한 오픈리딩프레임으로 구성되는 군 중에서 선택되는 그것의 단편;
    (f) L2 영역, 또는 펜톤, VII, VI, 및 X 단백질에 대한 오픈리딩프레임으로 구성되는 군으로부터 선택되는 그것의 단편;
    (g) L3 영역, 또는 VI, 헥손, 또는 엔도프로테아제에 대한 오픈리딩프레임으로 구성되는 군으로부터 선택되는 그것의 단편;
    (h) DNA-결합 단백질(DBP)에 대한 오픈리딩프레임을 포함하는 E2a 단백질;
    (i) L4 영역, 또는 100 kD 단백질, 33 kD 상동체, 22kD 상동체 및 VIII에 대한 오픈리딩프레임으로 구성되는 군으로부터 선택되는 그것의 단편;
    (j) E3 영역, 또는 12.5K, CR1-알파, gp19K, CR1-베타, CR1-감마, CR1-델타, RID-알파, RID-베타, 및 14.7 K에 대한 오픈리딩프레임으로 구성되는 군으로부터 선택되는 그것의 단편;
    (k) L5 영역, 또는 섬유 단백질에 대한 오픈리딩프레임으로부터 선택되는 그것의 단편;
    (l) E4 영역, 또는 E4 ORF6/7, E4 ORF6, E4 ORF4, E4 ORF3, E4 ORF2, 및 E4 ORF1에 대한 오픈리딩프레임으로 구성되는 군으로부터 선택되는 그것의 단편; 및
    (m) 유인원 아데노바이러스 39, SEQ ID NO:1; SAdV-25.2, SEQ ID NO: 130; 유인원 아데노바이러스 26, SEQ ID NO: 162, 유인원 아데노바이러스 30, SEQ ID NO: 98; 유인원 아데노바이러스 37, SEQ ID NO: 33; 유인원 아데노바이러스 38, SEQ ID NO: 65의 3' ITR
    로 구성되는 하나 이상의 군으로부터 선택되는 유인원 아데노바이러스 핵산 서열을 포함하는 벡터.
  19. 제 18 항에 따르는 핵산 서열에 의해 암호화되는 유인원 아데노바이러스 단백질.
  20. SEQ ID NO:30, 127, 159, 62, 95 및 191의 아미노산 서열로부터 선택되는 E1a;
    SEQ ID NO:24, 120, 153, 56, 89, 및 185의 아미노산 서열로부터 선택되는 E1b, 작은 T/19K;
    SEQ ID NO: 2, 99, 131, 34, 66, 및 163의 아미노산 서열로부터 선택되는 E1b, 거대 T/55K;
    SEQ ID NO:3, 100, 132, 35, 67, 및 164의 아미노산 서열로부터 선택되는 IX;
    SEQ ID NO:4, 101, 133, 36, 68, 및 165의 아미노산 서열로부터 선택되는 52/55D;
    SEQ ID NO:5, 102, 134, 37, 69 및 166의 아미노산 서열로부터 선택되는 IIa;
    SEQ ID NO:6, 103, 135, 38, 70, 및 167의 아미노산 서열로부터 선택되는 펜톤;
    SEQ ID NO: 7, 104, 136, 39, 71, 및 168의 아미노산 서열로부터 선택되는 VII;
    SEQ ID NO: 8, 105, 137, 40, 72, 및 169의 아미노산 서열로부터 선택되는 V;
    SEQ ID NO: 9, 106, 138, 41, 73, 및 170의 아미노산 서열로부터 선택되는 pX;
    SEQ ID NO: 10, 107, 139, 42, 74, 및 171의 아미노산 서열로부터 선택되는 VI;
    SEQ ID NO: 11, 108, 140, 43, 75, 및 172의 아미노산 서열로부터 선택되는 헥손;
    SEQ ID NO:12, 109, 141, 44, 76, 및 173의 아미노산 서열로부터 선택되는 엔도프로테아제;
    SEQ ID NO: 13, 110, 142, 45, 77, 및 174의 아미노산 서열로부터 선택되는 100 kD;
    SEQ ID NO: 32, 129, 161, 64, 97, 97, 및 193의 아미노산 서열로부터 선택되는 33 kD;
    SEQ ID NO: 26, 122, 155, 58, 91, 및 187의 아미노산 서열로부터 선택되는 22 kD;
    SEQ ID NO: 14, 111, 143, 46, 78, 및 175의 아미노산 서열로부터 선택되는 VIII;
    SEQ ID NO: 15, 123, 144, 47, 79, 및 176의 아미노산 서열로부터 선택되는 E3/12.5 K;
    SEQ ID NO:27, 112, 156, 59, 92, 및 188의 아미노산 서열로부터 선택되는 CR1-알파;
    SEQ ID NO: 16, 124, 145, 48, 87, 및 177의 아미노산 서열로부터 선택되는 gp19K;
    SEQ ID NO: 17, 113, 146, 49, 80, 및 178의 아미노산 서열로부터 선택되는 CR1-베타;
    SEQ ID NO:18, 114, 147, 50, 81, 및 179의 아미노산 서열로부터 선택되는 CR1-감마;
    SEQ ID NO: 19, 115, 148, 51, 82, 180의 아미노산 서열로부터 선택되는 CR1-델타;
    SEQ ID NO:20, 116, 149, 52, 83, 및 181의 아미노산 서열로부터 선택되는 RID-알파;
    SEQ ID NO:21, 117, 150, 53, 93, 및 182의 아미노산 서열로부터 선택되는 RID-베타;
    SEQ ID NO:28, 125, 158, 60, 84, 및 189의 아미노산 서열로부터 선택되는 E3/14.7K; 및
    SEQ ID NO:22, 118, 151, 54, 85 및 183의 아미노산 서열로부터 선택되는 섬유소로 구성되는 군으로부터 선택되는 하나 이상의 유인원 아데노바이러스 단백질을 포함하는 조성물.
  21. 제 20 항에 따르는 조성물을 피험자에 전달하는 단계를 포함하며, 상기 조성물은 헥손, 펜톤 및 섬유소로부터 선택되는 하나 이상의 유인원 아데노바이러스 SAdV-39, -25.2, -26, -30, -37, 및 -38 단백질인 아데노바이러스 수용체를 가지는 세포를 표적화하는 방법.
KR1020157025105A 2007-11-28 2008-11-24 유인원 ｅ 아데노바이러스 ｓａｄｖ-39, -25.2, -26, -30, -37, 및 -38 Expired - Fee Related KR101662574B1 (ko)

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