KR20170039096A - 암의 치료에 있어서 에리불린의 용도 - Google Patents

암의 치료에 있어서 에리불린의 용도 Download PDF

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Publication number: KR20170039096A
Authority: KR; South Korea
Prior art keywords: eribulin; agent; pharmaceutically acceptable; acceptable salt; breast cancer
Prior art date: 2014-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

KR1020167036565A

Other languages

English (en)

Korean (ko)

Inventor

브루스 에이. 리틀필드

마코토 아사노

준지 마츠이

마틴 올리보

요이치 오자와

얀케 유

Original Assignee

에자이 알앤드디 매니지먼트 가부시키가이샤

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-28

Filing date

2015-05-27

Publication date

2017-04-10

2015-05-27 Application filed by 에자이 알앤드디 매니지먼트 가부시키가이샤 filed Critical 에자이 알앤드디 매니지먼트 가부시키가이샤

2017-04-10 Publication of KR20170039096A publication Critical patent/KR20170039096A/ko

Status Ceased legal-status Critical Current

Links

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- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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Public Health (AREA)
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Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
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Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Reproductive Health (AREA)
Dermatology (AREA)
Endocrinology (AREA)
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Engineering & Computer Science (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

KR1020167036565A 2014-05-28 2015-05-27 암의 치료에 있어서 에리불린의 용도 Ceased KR20170039096A (ko)

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US201462003937P	2014-05-28	2014-05-28
US62/003,937		2014-05-28
PCT/US2015/032684 WO2015183961A1 (en)	2014-05-28	2015-05-27	Use of eribulin in the treatment of cancer

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KR20170039096A true KR20170039096A (ko)	2017-04-10

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US (1)	US20170100367A1 (2)
EP (1)	EP3148526B1 (2)
JP (1)	JP2017516802A (2)
KR (1)	KR20170039096A (2)
CN (1)	CN106413705A (2)
AU (1)	AU2015267099B2 (2)
BR (1)	BR112016026545A8 (2)
CA (1)	CA2950320A1 (2)
IL (2)	IL249220B (2)
MX (1)	MX2016015378A (2)
RU (1)	RU2699545C2 (2)
SG (1)	SG11201609777SA (2)
WO (1)	WO2015183961A1 (2)

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HRP20161157T1 (hr)	2009-03-30	2016-11-18	Eisai R&D Management Co., Ltd.	Liposomski pripravak
AU2014299699B2 (en)	2013-06-26	2019-10-10	Eisai R&D Management Co., Ltd.	Use of eribulin and lenvatinib as combination therapy for treatment of cancer
KR20170122810A (ko)	2015-03-04	2017-11-06	머크 샤프 앤드 돔 코포레이션	암을 치료하기 위한 pd-1 길항제 및 에리불린의 조합
WO2017188350A1 (ja)	2016-04-28	2017-11-02	エーザイ・アール・アンド・ディー・マネジメント株式会社	腫瘍の成長を抑制する方法
JP2020508315A (ja) *	2017-02-20	2020-03-19	ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒＡｇ	がんを治療するための薬剤組合せ
EP3654967A4 (en) *	2017-07-21	2021-04-21	Eisai R&D Management Co., Ltd.	USE OF EIBULIN AND CYCLINE-DEPENDENT KINASE INHIBITORS IN THE TREATMENT OF CANCER
EP3713565A1 (en)	2017-11-20	2020-09-30	Basilea Pharmaceutica International AG	Pharmaceutical combinations for use in the treatment of neoplastic diseases
JP2022506829A (ja) *	2018-11-09	2022-01-17	ジー１、セラピューティクス、インコーポレイテッド	エリブリンと選択的ｃｄｋ４／６阻害剤との組合せを使用する癌の処置のための治療レジメン
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US6653341B1 (en) *	1998-06-17	2003-11-25	Eisai Co., Ltd.	Methods and compositions for use in treating cancer
PL2522663T3 (pl)	2004-06-03	2015-08-31	Eisai R&D Man Co Ltd	Produkty pośrednie do otrzymywania halichondryny B
CN108948039B (zh)	2007-10-03	2021-12-31	卫材R&D管理有限公司	用于合成软海绵素b类似物的中间体和方法
CN102803254B (zh)	2010-01-26	2016-09-14	卫材R&D管理有限公司	用于软海绵素b类似物合成的呋喃并[3,2-b]吡喃衍生物
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2015
- 2015-05-27 JP JP2016569857A patent/JP2017516802A/ja active Pending
- 2015-05-27 MX MX2016015378A patent/MX2016015378A/es unknown
- 2015-05-27 US US15/314,160 patent/US20170100367A1/en not_active Abandoned
- 2015-05-27 AU AU2015267099A patent/AU2015267099B2/en not_active Ceased
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- 2015-05-27 WO PCT/US2015/032684 patent/WO2015183961A1/en not_active Ceased
- 2015-05-27 KR KR1020167036565A patent/KR20170039096A/ko not_active Ceased
- 2015-05-27 EP EP15799560.6A patent/EP3148526B1/en active Active
- 2015-05-27 BR BR112016026545A patent/BR112016026545A8/pt not_active Application Discontinuation
- 2015-05-27 CA CA2950320A patent/CA2950320A1/en not_active Abandoned
- 2015-05-27 RU RU2016151303A patent/RU2699545C2/ru active
- 2015-05-27 CN CN201580029099.0A patent/CN106413705A/zh active Pending
2016
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WO2021230561A1 (ko) *	2020-05-11	2021-11-18	연성정밀화학(주)	결정성 에리불린 염
US12486283B2 (en)	2020-05-11	2025-12-02	Yonsung Fine Chemical Co., Ltd.	Crystalline salt of eribulin

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AU2015267099A1 (en)	2017-01-05
IL249220A0 (en)	2017-02-28
IL276733A (en)	2020-09-30
WO2015183961A1 (en)	2015-12-03
RU2699545C2 (ru)	2019-09-06
US20170100367A1 (en)	2017-04-13
MX2016015378A (es)	2017-12-04
CA2950320A1 (en)	2015-12-03
AU2015267099B2 (en)	2020-08-27
RU2016151303A3 (2)	2019-01-17
JP2017516802A (ja)	2017-06-22
EP3148526A1 (en)	2017-04-05
AU2015267099A8 (en)	2020-08-27
BR112016026545A8 (pt)	2021-07-06
EP3148526A4 (en)	2018-03-14
BR112016026545A2 (pt)	2017-08-15
IL249220B (en)	2020-08-31
SG11201609777SA (en)	2016-12-29
RU2016151303A (ru)	2018-07-02
EP3148526B1 (en)	2021-01-06
CN106413705A (zh)	2017-02-15

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Publication	Publication Date	Title
EP3148526B1 (en)	2021-01-06	Use of eribulin in the treatment of cancer
US10238630B2 (en)	2019-03-26	Use of eribulin and poly (ADP ribose) polymerase (PARP) inhibitors as combination therapy for the treatment of cancer
EP3013335B1 (en)	2018-11-07	Combination therapy for the treatment of cancer comprising eribulin and lenvatinib
US20170071903A1 (en)	2017-03-16	Use of eribulin and mtor inhibitors as combination therapy for the treatment of cancer
CN112165945A (zh)	2021-01-01	治疗淋巴样恶性疾病之方法
KR20210008527A (ko)	2021-01-22	비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조성물 및 이의 사용 방법
CA3163635A1 (en)	2021-05-27	Lung targeted anticancer therapies with liposomal annamycin
EP4196116B1 (en)	2024-07-10	Pharmaceutical composition comprising cabozantinib, plerixafor, afatinib and etoricoxib for use in the treatment or prophylaxis of nsclc without driver mutations
US20200129473A1 (en)	2020-04-30	Use of eribulin and cyclin dependent kinase inhibitors in the treatment of cancer
CA3166741A1 (en)	2021-07-15	Combination therapy for treating cancer
TW200901989A (en)	2009-01-16	Anti-tumor activity of CCI-779 in papillary renal cell cancer
JP2025143272A (ja)	2025-10-01	がんを処置する方法及び使用
Greystoke et al.	2006	combination with carboplatin given on day 1 alone in patients with advanced solid tumours
HK1226654A1 (en)	2017-10-06	Anti-tumor activity of temsirolimus in papillary renal cell cancer
HK1226654A (en)	2017-10-06	Anti-tumor activity of temsirolimus in papillary renal cell cancer
HK1142538A (en)	2010-12-10	Anti-tumor activity of temsirolimus in papillary renal cell cancer