KR20180132059A - 피페라진 유도체의 거울상이성질체들을 분리하는 방법 - Google Patents

피페라진 유도체의 거울상이성질체들을 분리하는 방법 Download PDF

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Publication number
KR20180132059A
KR20180132059A KR1020187027126A KR20187027126A KR20180132059A KR 20180132059 A KR20180132059 A KR 20180132059A KR 1020187027126 A KR1020187027126 A KR 1020187027126A KR 20187027126 A KR20187027126 A KR 20187027126A KR 20180132059 A KR20180132059 A KR 20180132059A
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KR
South Korea
Prior art keywords
acid
ethyl
piperazine
formula
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020187027126A
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English (en)
Korean (ko)
Inventor
안나 콰트로파니
산토쉬 에스. 쿨카르니
아왓두트 가젠드라 기리
요하네스 니콜라스 쿡
Original Assignee
아셰뉴론 에스아
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 아셰뉴론 에스아 filed Critical 아셰뉴론 에스아
Publication of KR20180132059A publication Critical patent/KR20180132059A/ko
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020187027126A 2016-02-25 2017-02-24 피페라진 유도체의 거울상이성질체들을 분리하는 방법 Withdrawn KR20180132059A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201621006637 2016-02-25
IN201621006637 2016-02-25
PCT/EP2017/054272 WO2017144635A1 (fr) 2016-02-25 2017-02-24 Procédé de séparation d'énantiomères de dérivés de pipérazine

Publications (1)

Publication Number Publication Date
KR20180132059A true KR20180132059A (ko) 2018-12-11

Family

ID=58159075

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187027126A Withdrawn KR20180132059A (ko) 2016-02-25 2017-02-24 피페라진 유도체의 거울상이성질체들을 분리하는 방법

Country Status (12)

Country Link
US (1) US10344021B2 (fr)
EP (1) EP3419974B1 (fr)
JP (1) JP2019510007A (fr)
KR (1) KR20180132059A (fr)
CN (1) CN108884081B (fr)
AU (1) AU2017222960A1 (fr)
BR (1) BR112018017213A2 (fr)
CA (1) CA3014376A1 (fr)
EA (1) EA201891437A1 (fr)
MX (1) MX2018010199A (fr)
SG (1) SG11201807005VA (fr)
WO (1) WO2017144635A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3868752A1 (fr) 2014-08-28 2021-08-25 Asceneuron SA Inhibiteurs de la glycosidase
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
AU2017222958B2 (en) 2016-02-25 2019-07-18 Asceneuron S. A. Glycosidase inhibitors
CN108884078A (zh) 2016-02-25 2018-11-23 阿森纽荣股份公司 糖苷酶抑制剂
SG11201807012QA (en) 2016-02-25 2018-09-27 Asceneuron S A Acid addition salts of piperazine derivatives
WO2019037860A1 (fr) 2017-08-24 2019-02-28 Asceneuron S.A. Inhibiteurs linéaires de la glycosidase
WO2020039028A1 (fr) 2018-08-22 2020-02-27 Asceneuron S. A. Inhibiteurs de tétrahydro-benzoazépine glycosidase
WO2020039029A1 (fr) 2018-08-22 2020-02-27 Asceneuron S. A. Composés spiro utilisés en tant qu'inhibiteurs de glycosidases
WO2020039027A1 (fr) 2018-08-22 2020-02-27 Asceneuron S. A. Inhibiteurs de pyrrolidine glycosidase
IL280841B2 (en) 2018-08-22 2024-12-01 Asceneuron S A Succinate and fumarate acid addition salts of piperazine derivatives useful as glycosidase inhibitors
CN109374808B (zh) * 2018-11-08 2020-09-29 上海明捷医药科技有限公司 测定琥珀酸索利钠新原料药中苯胺类基因毒性杂质的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1311316A (fr) * 1961-04-12 1962-12-07 Science Union Et Compagnie Soc Nouveaux dérivés de la pipérazine et leurs préparations
CA2448080A1 (fr) * 2001-05-22 2002-11-28 Neurogen Corporation Ligands recepteurs de l'hormone de concentration de la melanine: analogues de 1-benzyl-4-aryl piperazine substituee
JP2010520199A (ja) * 2007-03-02 2010-06-10 シェーリング コーポレイション ピペリジン誘導体およびその使用方法
PT2970272T (pt) * 2013-03-14 2019-06-05 Merck Patent Gmbh Inibidores de glicosidase
EP3868752A1 (fr) * 2014-08-28 2021-08-25 Asceneuron SA Inhibiteurs de la glycosidase

Also Published As

Publication number Publication date
EA201891437A1 (ru) 2019-03-29
US10344021B2 (en) 2019-07-09
EP3419974A1 (fr) 2019-01-02
JP2019510007A (ja) 2019-04-11
EP3419974B1 (fr) 2021-05-05
WO2017144635A1 (fr) 2017-08-31
BR112018017213A2 (pt) 2019-01-02
MX2018010199A (es) 2019-05-20
SG11201807005VA (en) 2018-09-27
CN108884081A (zh) 2018-11-23
CN108884081B (zh) 2022-11-01
AU2017222960A1 (en) 2018-08-16
CA3014376A1 (fr) 2017-08-31
US20190062316A1 (en) 2019-02-28

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20180919

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1202 Submission of document of withdrawal before decision of registration

Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment)

Patent event code: PC12021R01D

Patent event date: 20210122

WITB Written withdrawal of application