KR20190042151A - Anti-fungal composition derived from natural products - Google Patents

Abstract

Discloses a natural antifungal composition that exhibits a killing effect against various fungi. The natural antifungal composition according to the present invention contains nuyin, xylitol, vitamin C, manuka honey, boswellia, myrrh and propolis in powder, liquid or extract form.

Description

ANTI-FUNGAL COMPOSITION DERIVED FROM NATURAL PRODUCTS [0002]

The present invention relates to an antifungal composition, and more particularly to a natural antifungal composition exhibiting a killing effect against various kinds of skin parasitic fungi.

Currently, only four types of antifungal drugs are available for the treatment of systemic fungal infections. These include polyenes (e.g., amphotericin B), azoles (e.g., ketoconazole or itraconazole), echinocandins (e.g., carportopan) and fluocytosine. The polyenes are the oldest types of antifungal compounds first introduced in the 1950s. The exact mode of action is not yet clear, but the polyenes are only effective for organisms containing sterols in their outer membranes. It has been suggested that amphotericin B interacts with the membrane sterols to form pores, which cause cellular components to leak and kill the cells. Azoles function by inhibition of 14 alpha-demethylating enzymes through cytochrome P450-dependent mechanisms. This causes depletion of the membrane sterol ergosterol and accumulation of sterol precursors, altering the fluidity and structure of the plasma membrane. Echinocandin acts by inhibition of cell wall synthetase β-glucan synthase. This causes abnormal cell wall formation, osmotic sensitivity and cell lysis. Fluocytosine is a pyrimidine analogue that interferes with cell pyrimidine metabolism, and DNA, RNA, and protein synthesis. However, extensive resistance to fluocytosine limits its therapeutic utility. It can be seen that the fungicide compositions currently available today mainly act on only two cell targets, membrane sterols (polyenes and azoles) and beta -glucan synthases (echinocandins). Resistance to both azoles and polyenes has been extensively reported, and as a result, only recently introduced echinocandin remains to fight invasive fungal infections. Due to the increased use of echinocandin, resistance to fungi will inevitably occur. Recently, pyrrole compounds have also been identified as antifungal compositions. WO 2009 130481 discloses pyrrol compounds which can be used for the prevention or treatment of fungal diseases.

These compounded antifungal compositions are chemically synthesized products, which are known to have not only a problem of tolerance but also a relatively large human toxicity.

Therefore, it is required to develop a natural-material-derived antifungal compound composition which is extracted from a natural product having no human toxicity and can bring about a positive treatment result for all the fungi.

Korean Registered Patent Publication No. 10-1346412 (Registration date: December 23, 2013) Korean Patent Laid-Open Publication No. 10-2016-0096601 (published date: 2016.08.16) Korean Unexamined Patent Application Publication No. 10-2016-0058294 (published date: May 2015) Korean Registered Patent Publication No. 10-0846356 (Registered Date: July 07, 2008)

Disclosure of Invention Technical Problem [8] The present invention has been made in order to solve the problems of the conventional antifungal composition described above, and a first object to be solved by the present invention is to provide an antifungal composition derived from a natural product having no toxicity to human body.

A second object to be solved by the present invention is to provide a natural antifungal compound composition which exhibits a wide range of effects against most fungi such as ringworm (dermatophytosis), rash, flocculation, candidiasis and the like.

The above-described problems of the present invention can be solved by a natural antifungal composition comprising a nutrient, xylitol, vitamin C, manuka honey, boswellia, myrrh and propolis in powder, liquid or extract form.

The natural antifungal composition according to the present invention may be prepared by mixing manuka honey and propolis in a mixed powder of Nuyin, xylitol, vitamin C, boswellia and myrrh to make pills, granules or powders.

The natural antifungal composition according to the present invention may be prepared by mixing manuka honey with a mixed powder of nuyin, xylitol, vitamin C, boswellia extract, myrrh and propolis extract to form a pill, granule or powder.

The natural antifungal composition according to the present invention is a natural antifungal composition comprising xanthorrhoid, vitamin C, manuka honey, boswellia, myrrh and propolis at a predetermined ratio, and extracting the extract with water or ethanol or water and ethanol as an active ingredient Granules, powders, or liquid formulations.

The object of the present invention is to provide a natural antifungal composition comprising the natural antifungal composition as described above and a powder, liquid or extract (powder), liquid (s), or extract (s) of celestial gong, crust (citrus fruit), sea bream, maple syrup, Can be more effectively solved by applying together a lymphocyte promoter contained in the form of a lymphocyte.

The natural antifungal composition of the present invention made of a natural material composite agent exhibited an effect on a wide range of fungi and exhibited a highly effective sterilizing action not only against surface fungal infection but also against deep fungal infection.

The natural antifungal composition according to the present invention contains nuyin, xylitol, vitamin C, manuka honey, boswellia, myrrh and propolis in powder, liquid or extract form.

The present invention relates to a pharmaceutical composition comprising i) 5-60% by weight (based on the total weight, hereinafter) of a compound known to have an antimicrobial function, ii) 10-40% by weight of xylitol also known to have antibacterial activity, and iii) 1 to 20% by weight of known vitamin C, iv) 1 to 20% by weight of Manuka honey known to have antibacterial active substances, v) 1 to 20% by weight of boswellia known to have detoxification function, and vi) 1 to 20% by weight of molfetine known to have hemihypertensive function, and vii) 0.1 to 10% by weight of propolis, an antibacterial agent extracted from beehive, to have a wide range of antifungal effects.

Adding less than 5% by weight of nifedipine is insignificant for the antifungal effect by nifedipine. Addition of more than 60% by weight of nifedipine does not increase the antifungal effect by the witch, but it is difficult to add antifungal function by other materials. Lt; / RTI > When xylitol is added in an amount of less than 10% by weight, the effect of xylitol is insufficient, and when xylitol is added in an amount of more than 40% by weight, the effect of xylitol is not increased. On the other hand, Lt; / RTI > When vitamin C is added in an amount of less than 1% by weight, the effect of vitamin C is insignificant. When vitamin C is added in an amount of more than 20% by weight, the effect of vitamin C is not increased. It is difficult to make it effective for a wide range of fungi. Adding less than 1% by weight of manuka honey has little effect on the antifungal effect of manuka honey. Addition of more than 20% by weight of manuka honey has little effect on the antifungal effect of manuka honey. It is difficult to make it effective for a wide range of fungi. When the boswellia is added in an amount of less than 1% by weight, the effect of the antifungal agent by the boswellia is insignificant. When the boswellia is added in an amount of more than 20% by weight, It is difficult to add an antifungal function and thus it is difficult to have efficacy against a wide range of fungi. Addition of less than 1% by weight of myrrh has little effect on the antifungal effect caused by myrrh. Addition of more than 20% by weight of myrrh has little effect on the antifungal effect of myrrh, Lt; / RTI > Addition of less than 0.1% by weight of propolis is insufficient for the antifungal effect of propolis, and addition of propolis more than 10% by weight results in less increase of antifungal effect by propolis, while addition of antifungal effect by other ingredients It is difficult to make it effective for a wide range of fungi.

The natural antifungal composition according to the present invention may be prepared by mixing manuka honey and propolis in a mixed powder of Nuyin, xylitol, vitamin C, boswellia and myrrh to make pills, granules or powders.

The natural antifungal composition according to the present invention can be prepared into a pill, granule, or powder for internal use by further mixing manuka honey with mixed powders of Nuyin, xylitol, vitamin C, boswellia extract, myrrh and propolis extract.

The natural antifungal composition according to the present invention is a natural antifungal composition comprising xanthorrhoid, vitamin C, manuka honey, boswellia, myrrh and propolis at a predetermined ratio, and extracting the extract with water or ethanol or water and ethanol as an active ingredient Granules, powders, or liquid formulations for oral use.

The natural antifungal composition according to the present invention is a natural antifungal composition comprising xanthorrhoid, vitamin C, manuka honey, boswellia, myrrh and propolis at a predetermined ratio, and extracting the extract with water or ethanol or water and ethanol as an active ingredient External packs (packs), cosmetics, soaps or shampoos.

Uiin is a dried rice plant of Yulmu which is a paddy plant. Yulmu is planted in various parts of our country. In the fall, the seeds are ripe, then the topping is cut and dried, and the seeds are peeled off. The taste is sweet and the quality is a bit cold. It is known to act on the nerves (脾 经) and menopause (肺 经). It makes the stomach (stomach stomach) strong, the urine comes out well, the fever is lowered and the pus is pulled out. In pharmacological experiments, anti-inflammatory effects, blood cholesterol-lowering effects, anti-cancer effects, anti-hypertensive effects, sedative and analgesic effects were found. In one room, it is also used for edema, dysuria, diarrhea caused by diarrhea, ula, pulmonary ab- scess, acute appendicitis, chronic gastritis, gastric cancer, chronic hepatitis, nephritis and malnutrition . Recently, the antimicrobial action of Nadine has been known (PCT International Publication No. WO 2000/13697).

Xylitol is extracted from the bark and sap of five decadic species (Betula platyphylla var. Japonica Hara, Birch), Betula platyphylla Sukatschev (Manchuria birch), etc., belonging to the Betulaceae family (Scientific name: Betula platyphylla var. Japonica Hara) (C ₅ H ₁₂ O _5, molecular weight 152.15). In Oriental medicine, birch has been known to have beneficial effects on skin and sap. It is known that birch bark is called as white bloom, bark, flower bark, etc. and has effects such as fever, water, detoxification, and extermination. Bronchitis, pneumonia and hepatitis, jaundice, nephritis, cystitis and so on.

Vitamin C is an antioxidant that protects the body against active oxygen (free radicals), preventing cancer, atherosclerosis, rheumatism, and strengthening the immune system. It is anticipated that when combined with other active ingredients, there is either an antifungal effect directly on vitamin C or an immunopotentiating effect that enhances the antifungal effect, it is included in the natural antifungal composition according to the present invention.

Honey has not only been used as food for thousands of years, but has also been used for medical purposes, primarily as an antibacterial agent. The main cause of the antibacterial active substance is the hydrogen peroxide produced in the honey by the enzyme glucose oxidizing agent. Although honey has a clear antibacterial effect, the antibacterial efficacy of honey varies substantially depending on the type of honey. Most of the compounds present in honey are included in the group of carbohydrates, enzymes, aromatic acids, hydrocarbons, straight-chain monovalent and divalent base acids and water. Honey is mainly composed of sugar glucose, fructose, sucrose and maltose, and contains many other oligosaccharides. The other substance added to the honey by bees is the amino acid with the most abundant proline and a small amount of catalase. These enzymatic catalase break down hydrogen peroxide into water and oxygen. Diacids including octandedioic, nonanedioic, decanedioic, and trans-2-decenedioic have also been reported to be present in honey.

The Manuka tree, Leptospermum scoparium, is native to New Zealand and can grow to a height of 6-8 m and a diameter of 7-10 cm, These flowers produce honey with a very strong aroma, called manuka honey. Manuka Honey not only moisturizes dry skin, it also has better antimicrobial action against damaged skin and Helicobacter pneumonia.

Manuka honey has an additional antibacterial active substance in addition to the antibacterial active substance of common honey. These additional active substances are known as peroxide active materials and are referred to as Unique Manuka Factors (UMF). These non-peroxide active substances, which contain large amounts of manuka honey, have a higher level of antibacterial activity that can not be accounted for by osmolarity, pH and glucose oxidant activity alone. There have been many studies to characterize the non-peroxide active substances (UMF) of manuka honey, and attempts have been made to identify the causative segments of these additional active substances, but despite many years of research, Non-peroxide components were not isolated or identified. In recent years, hydrogen peroxide is the only significant antibacterial substance of honey, hydrogen peroxide is produced by glucose oxidizing agents in honey or their segments, and other substances such as propolis-derived phenolic systems are not important compared to hydrogen peroxide, Studies have shown that the level of hydrogen peroxide is essentially determined by the amount of plant-derived catalase in honey, and Manuka honey has more plant-induced catalase than other honey. However, these findings also do not provide sufficient explanation or evidence for the presence or absence of the specific Manuka Factor (UMF). However, many studies have shown that such Manuka Honey Additional Active Substances (UMF) can be stable to heat and light, soluble in organic solvents such as ethanol and ether, The degree of activation was confirmed. Based on these properties revealed for manuka honey, the present inventors have found the direct antifungal effect of manuka honey and the immunity enhancing effect for enhancing antifungal effect, and they are included in the natural antifungal composition according to the present invention.

Bosswellia (frankincense) is a condensed and dried resin that exudes from the trunk and bark of a tropical plant, an olive tree belonging to the Burseraceae family. 60 to 70% of resin, 25 to 30% of glue, and essential oil. The frankincense has an efficacy of the vital quantity (the skin pruritus), the detoxification extinction (the action to remove the inflammation by the pathogenic microorganism), the blood circulation tongue (the ichi thalassemia) (Separate))> describes the treatment of swelling caused by Feng Shui (Feng Shui) and treatment of urticaria and itching. In addition, frankincense (frankincense) in Oriental medicine due to the ear (ear), paralyzed (风) the symptoms that do not speak it, the woman's bleeding symptoms, the colon diarrhea and feces bleeding and all the swelling and treatment Poison), eliminating the scent of air-cooling, raising (气) and jing (精). It strengthens the back and knees, regulates backache and abdominal pain caused by Shinhe (肾虛), and treats symptoms of severe abdominal pain and infectious disease through the involvement of bad fraud. Boil and make plaster to stop the pain, to raise the newborn, to treat the insomnia, to protect the kidneys, to stop the pain of all gangs, It cleanses the inside of the lesion by eliminating the poison of the swelling, removes the heart, and stops the pain by the action of the hibernation (livelihood) and relaxes the muscles. The inventors of the present invention have anticipated that there is a direct antifungal effect on boswellia or an immune-enhancing effect that enhances the antifungal effect from detoxification action, and boswellia is included in the natural anti-fungal composition according to the present invention.

The myrrh was found in the Burseraceae, which is a small branch of myrrh (myrrha), a stem of the myrrh (myrrha), and a yellow juice that exudes from the skin of the skin. The oily resin is dried to form a reddish brown mass. Myrrhin 25-40% (α, β, γ-comphoric acid), diplomatic 65%, ash and essential oil 2.5% ~8% (cuminaldehyde.eugenol). Myrrh is a kind of vaginal myrrh (extermal skin), which makes blood circulate well, eliminates eosinophilia, calms the swelling, stops the pain and causes the newborn to grow well. My stomach hurts my stomach, my stomachache, my stomach stopped, my bruises and sore trauma. Other wounds, inflammation of the mucous membranes can be used for a good effect. Convergent action, anti-inflammatory action, anti-fungal action, analgesic action. According to the reformed herb of the main herbaceous gangbok, the herb is removed, the pain is stopped, the trauma caused by the scalpel or bluntness is treated, and all swellings, It is said that it treats the lower blood, and it treats the symptoms that the eyes are covered with the sight, the dizziness, the pain and the skin are swollen. In oriental medicine, he removed Jinga (a disease in which a lump was formed in the abdomen) and ejaculation, regulated the aches, cured the weakness of the heart, and the lack of hepatic blood.

Propolis is used as an antibacterial agent in beehives as a resinous material collected by bees from the gum exudate of trees. So far, it is known that Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Trichomonas bacteria, Salmonella and the like are effective. Bees protect themselves from germs and fungi by spraying propolis in the cracks of the honeycomb, and prevent the invasion of enemies such as wasps or rats. Especially when the queen bee spawning, worker bees are used to clean the spawning place. Propolis includes substituted benzoic acid, cinnamic acid, and flavonoids. Flavonoids are the major antibacterial agents in propolis. Flavonoids identified as causative agents for antibacterial active substances include galangin, pinocembrin, caffeic acid and ferulic acid. The main efficacy of propolis is antibacterial, anti-inflammatory, analgesic, immune-enhancing, anti-cancer, and antioxidant. The anti-inflammatory effect is because it reduces the enzymes that cause prostaglandins, which cause inflammation in people's bodies, by up to half. The main ingredient, flavonoid, has antioxidant effect because it eliminates active oxygen. And quercetin, which has an anti-cancer effect, and blocks cancer genes before their genes are replicated. The present inventors have confirmed that propolis acts on fungal inflammation and that propolis is contained in the natural antifungal composition according to the present invention in anticipation of having an antifungal effect directly on propolis or an immunostimulating effect enhancing antifungal effect .

Among the constituents of the natural antifungal composition according to the present invention, xylitol, manuka honey, boswellia, myrrh and propolis are derived from natural life forms. These components are antimicrobial compositions that can exert a wide range of effects and are the crystal of immunity that has been constantly evolving for billions of years to defend itself against many kinds of fungal infections. Therefore, when the natural antifungal composition according to the present invention is applied to the human body, not only directly kills various kinds of fungi, but also directly or indirectly strengthens the immune function of the body to help the infected fungus to be eradicated.

Other features of fungal disease are repeated, depending on their health condition, without symptoms being clean. First of all, if you think only at the cell level, the cells that are infected with the fungus will be diseased cells, so it will be difficult for various metabolic activities to proceed normally. Therefore, it is presumed that already infected cells will accumulate pathological metabolites in the cells, weaken the cells themselves, decrease the life cycle of the cells, and react sensitively to the stimuli. Next, from a systemic point of view, The activity of the fungus varies greatly depending on the immunity. In other words, if the immune system is normal, it will survive only in the cell and will not cause any special lesion. When the immune system weakens, it infects surrounding cells and causes inherent lesions. According to the immune system, two cases are repeated and continue without symptoms.

The inventors of the present invention have found that, in addition to the present invention, the present inventors have found that the present invention relates to a method for producing a nutrient solution containing a citrine, a crust (citrus fruit), a sea bream, a maple syrup, Lymph circulation accelerator was further developed and patented separately.

The natural antifungal composition according to the present invention has a synergistic effect when administered in combination with the lymphocyte promoter. The lymphocyte promoter promotes the absorption of the active ingredient contained in the natural antifungal composition according to the present invention, facilitates the movement of the antifungal composition according to the present invention to the required site, Rapidly removes the substances, quickly cleanses the infected cells lost by taking the natural antifungal composition according to the present invention, and helps restore the normal cells.

<Examples>

1) In order to confirm the clinical test and the efficacy of the fungicidal disease, the natural product antifungal compound ring according to the present invention was produced several times in the following amounts.

A mixed powder of 3,200 g of powdered wool, 2,700 g of xylitol powder, 1,200 g of vitamin C powder, 500 g of boswellia extract powder, 1,000 g of myrrh powder and 200 g of propolis extract powder was mixed with 1,200 g of Manuka honey, A small circle of 3-5mm made about 10,000g and packed them in 4.8g units. In order to obtain boswellia extract and propolis extract, boswellia and propolis were mixed in a weight ratio of 50% ethanol and 1:30 (boswellia or propolis 1: 50% ethanol 30), respectively, The mixture was extracted at 120 DEG C for 3 to 12 hours. Then, the ethanol was evaporated for an appropriate time to remove the components of ethanol, and the residue was removed, followed by drying and pulverization.

2) In order to carry out clinical tests sequentially or concurrently with the natural antifungal composition according to the present invention, a lymphocyte promoter ring was produced several times in the following amounts.

Mixed powders of 2,700 g of astragalus powder, 1,400 g of citrus fruit (crust) powder, 1,100 g of sea bream (sea bream) powder and 800 g of powder of yulmu were mixed and mixed with 2,600 g of maple syrup and 1,400 g of bamboo A small circle with a diameter of 3-5 mm made about 10,000 g and packed them in 4.8 g unit.

The lymphocyte promoter has been developed by the present inventor and promotes lymphatic circulation to rapidly remove waste products and toxic substances accumulated in the lesion, thereby reducing symptoms and facilitating the supply of nutrients, oxygen, and moisture required by the cells, Helping to create the desired optimal environment. Thus, the symptoms of the antifungal composition according to the present invention are rapidly improved, and not only the prominent response caused by the use of the antifungal composition according to the present invention is reduced, but also the recovery of damaged cells is promoted.

The following clinical examples are obtained only for specific patients who have established a trust relationship with the present inventors among the patients selected by the present inventors through introduction of the surrounding, and the raw materials, composition, and composition of the natural antifungal composition according to the present invention, And the like are examples of the antifungal composition being developed by the present inventor and only the efficacy thereof and the clinical efficacy confirmed by the consent of the patient. In this process, the amounts other than the amounts taken directly by the patient were not provided at all, and the clinical tests were conducted while thoroughly controlling the natural antifungal composition according to the present invention to prevent leakage or transmission to the third party.

<Clinical Example 1> Toenail athlete's foot (46 years old, male)

The fourth claw and fifth claw athlete's foot was a severe 46-year-old male patient. The man was taking BARACLUDE as a carrier with hepatitis B virus. This patient has been using the athlete's foot medicine for about 10 years because of toxicity to the liver because of the toxicity of the chemical compound antifungal drug, but the toenail athlete's foot was severe and less severe. The natural antifungal agent composition according to the present invention was administered by tid for 1 week in one week for 4 weeks. At 4 weeks of taking, the improvement of the fourth toe began to be noticeable, and at the 4th week of administration, the fifth toenail athlete's foot improved by more than 80%. After taking 12 weeks, the 4th claw and 5th claw athlete's foot completely disappeared.

<Clinical Example 2> Ringworm (55 years old, male)

In the lower part of the right side of the right side of the face, a white line (dermatophytic fungus) of about 7 to 8 mm, which is about 24 months old, was observed. Tami silk cream was applied for 6 months, and at the same time, 3 capsules of ruconazole were taken once a week for 6 months. However, it was not weakened at all but rather spread to the periphery and widened slightly. The natural antifungal agent composition according to the present invention is administered in a bid for 1 week in bid for 4 weeks, and at the same time, the lymphocyte promoter is injected into a bid for 4 weeks Respectively. After 4 weeks, the color of the spots became dim and the size remarkably decreased. After 4 weeks of taking the same dose, the spot disappeared without any trace, and the skin color at the spot became the same as the surrounding skin color.

<Clinical Example 3> Wax (35 years, man)

This patient was observed at several places in the buttocks and groin, which were rounded. As it has been for a considerable period of time, the partial pigment has been deposited and it becomes very itchy. The natural antifungal agent composition according to the present invention is first administered twice in bid for 4 weeks, and at the same time, the lymphocyte promoter is injected into a bid for 4 weeks Respectively. After four weeks, itching disappeared, and the color became faded and the shape became more irregular. After 8 weeks of taking the same dose, most of the skin color of the area where the wax was placed returned to the surrounding skin color, and only a few spotted pigment remained. The itching completely disappeared.

Claims (3)

As antifungal compositions,
Xylitol, vitamin C, manuka honey, boswellia, myrrh and propolis in the form of powder, liquid or extract.
The antifungal composition according to claim 1, wherein the antifungal composition is prepared by mixing manuka honey with a mixed powder of nuyin, xylitol, vitamin C, boswellia extract, myrrh and propolis extract to form a pill, granule or powder Lt; / RTI &gt;
[Claim 2] The antifungal composition according to claim 1, wherein the antifungal composition is selected from the group consisting of: wool, xylitol, vitamin C, manuka honey, boswellia, myrrh and propolis at a certain ratio and extracting with water or ethanol or water and ethanol Wherein the natural antifungal agent is an antifungal agent.