KR20190130411A - 아픽사반 약제학적 제제 및 그의 제조방법 - Google Patents

아픽사반 약제학적 제제 및 그의 제조방법 Download PDF

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Publication number
KR20190130411A
KR20190130411A KR1020180055075A KR20180055075A KR20190130411A KR 20190130411 A KR20190130411 A KR 20190130411A KR 1020180055075 A KR1020180055075 A KR 1020180055075A KR 20180055075 A KR20180055075 A KR 20180055075A KR 20190130411 A KR20190130411 A KR 20190130411A
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KR
South Korea
Prior art keywords
apixaban
minutes
weight
pharmaceutical formulation
delay time
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020180055075A
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English (en)
Korean (ko)
Inventor
권석영
박윤상
구대환
이영빈
Original Assignee
신일제약주식회사
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Filing date
Publication date
Application filed by 신일제약주식회사 filed Critical 신일제약주식회사
Priority to KR1020180055075A priority Critical patent/KR20190130411A/ko
Priority to PCT/KR2019/005795 priority patent/WO2019221488A1/fr
Publication of KR20190130411A publication Critical patent/KR20190130411A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020180055075A 2018-05-14 2018-05-14 아픽사반 약제학적 제제 및 그의 제조방법 Withdrawn KR20190130411A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1020180055075A KR20190130411A (ko) 2018-05-14 2018-05-14 아픽사반 약제학적 제제 및 그의 제조방법
PCT/KR2019/005795 WO2019221488A1 (fr) 2018-05-14 2019-05-14 Formulation pharmaceutique comprenant de l'apixaban et son procédé de préparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020180055075A KR20190130411A (ko) 2018-05-14 2018-05-14 아픽사반 약제학적 제제 및 그의 제조방법

Publications (1)

Publication Number Publication Date
KR20190130411A true KR20190130411A (ko) 2019-11-22

Family

ID=68540479

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020180055075A Withdrawn KR20190130411A (ko) 2018-05-14 2018-05-14 아픽사반 약제학적 제제 및 그의 제조방법

Country Status (2)

Country Link
KR (1) KR20190130411A (fr)
WO (1) WO2019221488A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022115051A1 (fr) * 2020-11-27 2022-06-02 Santa Farma Ilac Sanayii A.S. Procédé de compression directe pour formulations d'apixaban non micronisées
CN113577035A (zh) * 2021-09-07 2021-11-02 山东仁和制药有限公司 一种阿哌沙班片及其制备方法
WO2024144207A1 (fr) * 2022-12-26 2024-07-04 Rexpharmtech Co., Ltd Comprimé à libération prolongée comprenant de l'apixaban

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090052346A (ko) 2006-09-12 2009-05-25 글락소 그룹 리미티드 인자 ｘａ 억제제를 포함하는 복수의 소형 정제를 포함하는제약 조성물
KR20120029428A (ko) 2009-06-16 2012-03-26 화이자 인코포레이티드 아픽사반의 투여 형태
KR20140046395A (ko) 2010-12-15 2014-04-18 메리온 리서치 Ⅲ 리미티드 경구 투여를 위한 선택적 인자 ｘａ 억제제의 제약 조성물
KR20160098508A (ko) 2013-12-23 2016-08-18 라보라토리오스 델 드라. 에스테브.에스.에이. 경구용 약학 조성물
KR101796300B1 (ko) 2010-02-25 2017-11-10 브리스톨-마이어스 스퀴브 홀딩스 아일랜드 아픽사반 제제

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238674A1 (en) * 2006-04-06 2007-10-11 Veltri Enrico P Tra combination therapies
US20130064888A1 (en) * 2011-08-08 2013-03-14 Roey Solomonovich Pharmaceutical formulations
CN103830199A (zh) * 2014-03-24 2014-06-04 重庆东得医药科技有限公司 含阿哌沙班的药用制剂及其制备方法
WO2017182908A1 (fr) * 2016-04-18 2017-10-26 Emcure Pharmaceuticals Limited Compositions pharmaceutiques d'apixaban

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090052346A (ko) 2006-09-12 2009-05-25 글락소 그룹 리미티드 인자 ｘａ 억제제를 포함하는 복수의 소형 정제를 포함하는제약 조성물
KR20120029428A (ko) 2009-06-16 2012-03-26 화이자 인코포레이티드 아픽사반의 투여 형태
KR101796300B1 (ko) 2010-02-25 2017-11-10 브리스톨-마이어스 스퀴브 홀딩스 아일랜드 아픽사반 제제
KR20140046395A (ko) 2010-12-15 2014-04-18 메리온 리서치 Ⅲ 리미티드 경구 투여를 위한 선택적 인자 ｘａ 억제제의 제약 조성물
KR20160098508A (ko) 2013-12-23 2016-08-18 라보라토리오스 델 드라. 에스테브.에스.에이. 경구용 약학 조성물

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