KR20230052995A - 시퀀싱 반응을 위한 중합 효소 - Google Patents

시퀀싱 반응을 위한 중합 효소 Download PDF

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KR20230052995A
KR20230052995A KR1020237012002A KR20237012002A KR20230052995A KR 20230052995 A KR20230052995 A KR 20230052995A KR 1020237012002 A KR1020237012002 A KR 1020237012002A KR 20237012002 A KR20237012002 A KR 20237012002A KR 20230052995 A KR20230052995 A KR 20230052995A
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조나단 엠. 로스버그
브라이언 리드
모함마드 와두드 부이야
만줄라 판데이
토마스 크리스티안
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Abstract

변형된 재조합 중합 효소를 포함하는 조성물이, 이러한 변형된 중합 효소를 코딩하는 핵산 분자와 함께 제공된다. 일부 측면에서, 핵산 분자를 합성하거나 또는 핵산 주형을 시퀀싱하기 위해 이러한 중합 효소를 사용하는 방법이 제공된다.

Description

시퀀싱 반응을 위한 중합 효소{POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS}
관련 출원
본 출원은 35 U.S.C. § 119(e) 하에, 2016년 12월 19일에 출원된 미국 가출원 번호 62/436,410을 우선권 주장하며, 이 가출원은 그 전문이 본원에 참조로 포함된다.
본 출원의 분야
본 출원은 일반적으로, 생물학적 및/또는 화학적 샘플의 시퀀싱 분석을 위한 방법 및 조성물에 관한 것이다.
DNA 폴리머라제는 모든 생물체의 게놈 복제에 필수적인 뉴클레오티드 중합 효소이다. DNA 폴리머라제는 복제 및 복구 동안 게놈 무결성을 유지하는 역할 이외에도, DNA 클로닝, 돌연변이 유발, 및 시퀀싱을 포함하여 시험관 내에서의 DNA 조작을 위해 널리 사용되고 있다. 주형 DNA에 따라 상보적 가닥을 합성할 수 있는 DNA 폴리머라제의 기본적인 능력은 보존되지만, 효소 간에는 전진성(processivity), 충실도, 및 기질 뉴클레오티드 선택성을 포함한 특이적 특성이 상이하다.
본원에 개시된 기술의 측면은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 중합 효소 (예를 들어, 폴리머라제)에 관한 것이다. 일부 측면에서, 본원에 기재된 폴리머라제는 시퀀싱 반응 (예를 들어, 핵산 시퀀싱)에 사용하기 적합하다. 일부 측면에서, 본 개시내용은 하나 이상의 변형을 갖는 재조합 폴리머라제를 제공한다. 일부 실시양태에서, 본 개시내용의 재조합 폴리머라제는 아미노산 돌연변이 또는 도메인 치환 중 적어도 하나를 포함한다.
일부 측면에서, 본 개시내용은 자연 발생 폴리머라제 (예를 들어, 표 1로부터 선택됨)에 기초하고 하나 이상의 아미노산 돌연변이 및/또는 절편 치환을 포함하는 아미노산 서열을 갖는 변형된 중합 효소 (예를 들어, 핵산 중합 효소, 또는 핵산 폴리머라제)를 제공한다. 일부 실시양태에서, 변형된 중합 효소는 하나 이상의 절편 치환 (예를 들어, 여기서 폴리머라제의 하나 이상의 절편이 상이한 폴리머라제로부터의 하나 이상의 상응하는 절편으로 대체된다), 하나 이상의 아미노산 부가, 결실, 및/또는 치환, 또는 그의 조합을 포함한다. 일부 실시양태에서, 절편은 폴리머라제의 규정된 영역 (예를 들어, 구조적 또는 기능적 도메인 또는 서브 도메인), 또는 그의 부분을 포함하며, 이는 하나 이상의 플랭킹 아미노산 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 특정 영역 또는 그의 부분의 어느 한쪽 상의 아미노산 1 내지 50개, 1 내지 40개, 1 내지 30개, 1 내지 20개, 5 내지 10개, 5 내지 25개, 또는 이들 범위 내의 임의의 정수)을 임의로 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 하나 이상의 위치에서 2개의 자연 발생 폴리머라제 간의 자연 발생 차이에 상응한다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 새로운 비-자연 발생 변화이다. 일부 실시양태에서, 아미노산 치환은 보존적 아미노산 치환 (예를 들어, 하나의 아미노산을 유사한 특성, 예를 들어 유사한 하전, 극성, 소수성, 친수성, 및/또는 다른 유사한 특성, 예컨대 유사한 크기를 갖는 또 다른 아미노산으로 대체시킨다)이다. 일부 실시양태에서, 아미노산 치환은 비-보존적 아미노산 치환이다. 일부 실시양태에서, 하나 이상의 아미노산 삽입, 결실, 또는 치환은 상이한 폴리머라제로부터의 하나 이상의 교환된 절편 내 및/또는 원래의 폴리머라제의 절편 내를 포함하여, 변형된 폴리머라제 내의 임의의 위치(들)에서 일어날 수 있다.
따라서, 일부 실시양태에서 본 개시내용은 표 1로부터 선택된 아미노산 서열 (또는 표 1로부터 선택된 아미노산 서열에 대해 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 80-90%, 90-95%, 95-99%, 또는 그 초과의 아미노산 서열 동일성을 갖는 아미노산 서열)을 갖고, 표 2, 표 3, 표 4, 또는 표 5로부터의 하나 이상의 아미노산 변형을 포함하는 재조합 중합 효소를 제공한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 아미노산 돌연변이 (예를 들어, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25개, 또는 그 초과의 아미노산 돌연변이)를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 1개 내지 5개 이하의 아미노산 돌연변이, 적어도 1개 내지 10개 이하의 아미노산 돌연변이, 적어도 1개 내지 15개 이하의 아미노산 돌연변이, 적어도 1개 내지 25개 이하의 아미노산 돌연변이, 적어도 1개 내지 50개 이하의 아미노산 돌연변이, 또는 적어도 1개 내지 100개 이하의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 도메인 치환 (예를 들어, 전체 도메인의 치환, 또는 특정 도메인 또는 특정 도메인의 부분을 포괄하는 절편의 치환)을 포함한다. 일부 실시양태에서, 적어도 하나의 도메인 치환은 엑소뉴클레아제 도메인 치환 및 폴리머라제 도메인 치환 중 적어도 하나를 포함한다. 일부 실시양태에서, 엑소뉴클레아제 도메인 치환은 엑소뉴클레아제 루프 치환을 포함한다. 일부 실시양태에서, 폴리머라제 도메인 치환은 팜(palm) 서브 도메인 치환, TPR1 서브 도메인 치환, 핑거 서브 도메인 치환, TPR2 서브 도메인 치환, 또는 섬(thumb) 서브 도메인 치환 중 어느 하나 (예를 들어, 전체의 폴리머라제, 팜, TPR1, 핑거, TPR2, 또는 섬 도메인 또는 서브 도메인, 또는 하나 이상의 플랭킹 아미노산을 임의로 포함한 그 중 어느 하나의 부분의 치환)를 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 변형은 적어도 하나의 도메인 치환 및 적어도 하나의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 아미노산 돌연변이는 아미노산 삽입, 결실, 또는 치환일 수 있다.
일부 실시양태에서, 본 개시내용의 재조합 중합 효소는 표 2로부터 선택된 서열을 갖는다. 일부 실시양태에서, 본 개시내용은 표 3으로부터 선택된 서열을 갖는 재조합 중합 효소를 제공한다.
일부 실시양태에서, 재조합 중합 효소는 정제 태그를 추가로 포함한다. 일부 실시양태에서, 정제 태그는 중합 효소 서열 내의 영역과 공유 결합된다. 일부 실시양태에서, 정제 태그는 중합 효소 서열의 말단 단부와 공유 결합된다. 일부 실시양태에서, 정제 태그는 C-말단 태그이다. 일부 실시양태에서, 정제 태그는 N-말단 태그이다. 일부 실시양태에서, 정제 태그는 His 태그 (예를 들어, 반복 히스티딘 잔기의 서열, 예컨대 헥사히스티딘 서열)이다.
일부 실시양태에서, 재조합 중합 효소는 커플링 기를 추가로 포함한다. 일부 실시양태에서, 커플링 기는 중합 효소 서열 내의 영역에 부착된다. 일부 실시양태에서, 커플링 기는 중합 효소의 말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 재조합 중합 효소의 C-말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 재조합 중합 효소의 N-말단 단부에 부착된다. 일부 실시양태에서, 커플링 기는 비오티닐화 서열이다. 일부 실시양태에서, 재조합 중합 효소는 펩티드 링커 (예를 들어, 5 내지 15개의 아미노산 또는 그 초과의 길이)와 직접적으로 연결되거나 또는 이러한 링커에 의해 분리된 정제 태그 (예를 들어, His 태그)와 커플링 기 (예를 들어, 비오티닐화 서열)를 포함한다 (예를 들어, 그의 C 말단에 포함한다).
일부 실시양태에서, 재조합 중합 효소는 특정 표면 상에 고정화된다. 일부 실시양태에서, 이러한 표면은 재조합 중합 효소와 결합하도록 설정된 커플링 기를 포함한다. 일부 실시양태에서, 상기 표면은 나노개구를 포함한다. 일부 실시양태에서, 상기 표면은 샘플 웰의 바닥면을 포함한다. 일부 실시양태에서, 샘플 웰은 표면 (예를 들어, 칩 또는 통합 장치의 표면) 상의 복수 개의 샘플 웰 사이에 배치된다. 일부 실시양태에서, 복수 개의 샘플 웰 각각은 재조합 중합 효소를 수용하도록 설정된다. 일부 실시양태에서, 재조합 중합 효소를 포함하는 복수 개의 샘플 웰 각각은 단일 분자 시퀀싱 반응을 시행할 수 있다.
일부 측면에서, 본 개시내용은 본원에 기재된 재조합 중합 효소를 코딩하는 단리된 핵산 분자를 제공한다. 일부 실시양태에서, 이러한 단리된 핵산 분자는 RNA를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 DNA를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 바이러스 벡터를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 발현 벡터를 포함한다. 일부 실시양태에서, 단리된 핵산 분자는 플라스미드를 포함한다. 일부 실시양태에서, 단리된 핵산은 프로모터 (예를 들어, 유도성 프로모터)를 포함한다. 일부 실시양태에서, 단리된 핵산은 재조합 중합 효소를 발현할 수 있는 숙주 세포 내에 있다. 일부 실시양태에서, 재조합 중합 효소는 숙주 세포로부터 (예를 들어, 바이오리액터에서의 성장 및 유도성 프로모터의 유도 후, 예를 들어 숙주 세포 제제로부터) 단리된다.
일부 측면에서, 본 개시내용은 본 출원에 기재된 재조합 중합 효소를 포함하는 조성물을 제공한다. 일부 실시양태에서, 이러한 조성물은 핵산을 시퀀싱하는 방법에 사용된다. 일부 실시양태에서, 상기 조성물은 시퀀싱 반응 혼합물을 추가로 포함한다. 일부 실시양태에서, 시퀀싱 반응 혼합물은 뉴클레오시드 폴리포스페이트 (예를 들어, 2개 이상의 포스페이트 기를 포함하는 뉴클레오시드, 예컨대 뉴클레오티드 또는 뉴클레오시드 헥사포스페이트), 시퀀싱될 주형 핵산, 상보적 가닥 합성을 위한 출발점으로서 제공되는 핵산 프라이머, 2가 금속 이온, 완충제 성분, 및 염 중 하나 이상을 포함할 수 있다. 일부 실시양태에서, 뉴클레오시드 폴리포스페이트는 검출 가능한 모이어티 (예를 들어, 발광 표지)를 포함한다.
일부 측면에서, 본 개시내용은 본 출원에 기재된 재조합 중합 효소를 시퀀싱 반응 혼합물과 접촉시킴으로써 핵산을 시퀀싱하는 방법을 제공한다. 일부 실시양태에서, 시퀀싱 반응 혼합물은 뉴클레오시드 폴리포스페이트 (예를 들어, 2개 이상의 포스페이트 기를 포함하는 뉴클레오시드, 예컨대 뉴클레오티드 또는 뉴클레오시드 헥사포스페이트), 시퀀싱될 주형 핵산, 상보적 가닥 합성을 위한 출발점으로서 제공되는 핵산 프라이머, 2가 금속 이온, 완충제 성분, 및 염 중 하나 이상을 포함할 수 있다. 일부 실시양태에서, 뉴클레오시드 폴리포스페이트는 발광 표지를 포함한다. 일부 실시양태에서, 상기 방법은 주형 핵산에 상보적인 성장 가닥 내의 하나 이상의 뉴클레오시드 폴리포스페이트의 혼입을 검출하는 것을 추가로 포함한다. 일부 실시양태에서, 검출하는 것은 혼입 이벤트에 관여하는 발광성 표지된 뉴클레오시드 폴리포스페이트의 하나 이상의 발광 특성 (예를 들어, 수명, 세기, 광자 도착 시간, 양자 수율)을 측정하는 것을 포함한다.
일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 엑소뉴클레아제 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 팜 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 TPR1 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 핑거 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 TPR2 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 표 1에서의 재조합 중합 효소 중 어느 하나의 섬 영역 또는 그의 부분 (및 임의로, 한쪽 또는 양쪽 상의 플랭킹 아미노산)을 포함하는 절편을 포함하는 재조합 중합 효소를 제공한다. 일부 측면에서, 본 개시내용은 본원에 기재된 바와 같은 2개 이상의 절편을 포함하는 재조합 중합 효소를 제공한다.
따라서, 일부 실시양태에서, 재조합 중합 효소는 상이한 중합 효소로부터의 (예를 들어, 상이한 종으로부터의) 하나 이상의 아미노산 절편을 포함하는 키메라 효소이다. 일부 실시양태에서, 키메라 폴리머라제는 하나 이상의 절편을 상이한 중합 효소로부터의 절편(들)으로 대체시킨 제1 중합 효소로부터의 아미노산 서열을 포함한다. 일부 실시양태에서, 상이한 중합 효소로부터의 하나 이상의 절편은 M2Y 폴리머라제로부터의 아미노산 1-51을 포함하는 절편, 이. 파에시움(E. faecium) 폴리머라제로부터의 아미노산 271-375를 포함하는 절편, 이. 파에시움 폴리머라제로부터의 아미노산 72-89를 포함하는 절편, 및/또는 이. 파에시움 폴리머라제로부터의 아미노산 445-449를 포함하는 절편일 수 있다. 일부 실시양태에서, M2Y 폴리머라제로부터의 1-51 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 1-54)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 271-375 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 260-359)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 72-89 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 75-91)을 대체한다. 일부 실시양태에서, 이. 파에시움 폴리머라제로부터의 445-449 절편이 상응하는 자연 발생 폴리머라제 절편 (예를 들어, Φ29 폴리머라제의 아미노산 429-433)을 대체한다.
일부 실시양태에서, 재조합 중합 효소는 Φ29 내에서의 하기 치환에 상응하는 하나 이상의 치환을 포함한다: M8R, V51A, N62D, I71V, L107I, K131E, K135Q, L142K, G197D, Y224K, E239G, V250A/I, L253A/H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K/R, K512Y, E515Q, K539E, D570S, 및 T571V.
일부 실시양태에서, 변형된 폴리머라제는 본원에 기재된 절편 치환 및/또는 아미노산 삽입, 결실, 및/또는 치환 중 하나 이상을 포함하고, 또한 하나 이상의 (예를 들어, 1-5, 5-10, 10-25, 25-50, 50-75, 75-100, 100-125, 125-150개의) 부가의 아미노산 삽입, 결실, 및/또는 치환 (예를 들어, 보존적 또는 비-보존적 아미노산 치환)을 포함한다. 따라서, 일부 실시양태에서, 표 2 또는 표 3의 변형된 폴리머라제는 하나 이상의 (예를 들어, 1-5, 5-10, 10-25, 25-50, 50-75, 75-100, 100-125, 125-150개의) 부가의 아미노산 삽입, 결실, 및/또는 치환 (예를 들어, 보존적 또는 비-보존적 아미노산 치환)을 포함할 수 있다.
이들 및 다른 측면은 하기 상세한 설명에 보다 상세하게 기재되고 비-제한적 도면 및 실시예에 의해 예시된다.
통상의 기술자는 본원에 기재된 도면이 단지 예시하기 위한 것임을 이해할 것이다. 일부 경우에, 본 발명의 이해를 용이하게 하기 위하여, 본 발명의 다양한 측면이 과장되거나 또는 확대되어 보여질 수 있음을 이해해야 한다. 본 도면에서, 유사한 참조 문자는 일반적으로, 다양한 도면 전반에 걸쳐 유사한 특색, 기능적으로 유사하고/하거나 구조적으로 유사한 요소를 지칭한다. 본 도면은 반드시 축척된 것은 아니며, 대신 교시의 원리를 예시하는 것에 중점을 둔다. 본 도면은 어떤 방식으로든 본 교시의 범위를 제한하지 않는다.
본 발명의 특색 및 이점은 도면과 연계하여 후술되는 상세한 설명으로부터 더욱 명백해질 것이다.
본 도면과 관련하여 실시양태를 설명할 때, 방향에 대한 언급 ( "위", "아래", "상단", "하단", "좌측", "우측", "수평", "수직" 등)을 이용할 수 있다. 이러한 언급은 단지 정상적인 배향으로 본 도면을 보는 독자를 돕기 위한 것이다. 이들 방향 언급은 구체화된 장치의 선호되거나 또는 유일한 배향을 기재하기 위한 것이 아니다. 장치는 다른 배향으로 구체화될 수 있다.
상세한 설명으로부터 명백한 바와 같이, 본 도면 (예를 들어, 도 1 내지 도 7)에 도시되고 본 출원 전반에 걸쳐 예시의 목적으로 추가로 기재된 예들은 비-제한적 실시양태를 설명하고, 일부 경우에는 특정 프로세스를 단순화하거나 또는 더 명확하게 예시하기 위하여 특색 또는 단계를 생략할 수 있다.
도 1은 단일 분자 프로세스를 모니터링하기 위한 비-제한적 프로세스에서 시그널 판독정보와 관련하여 중합 반응의 진행을 예시하는 개략도이다.
도 2는 Φ29 폴리머라제의 구조 및 이러한 폴리머라제의 도메인 및 서브 도메인을 도시하는 비-제한적 예시이다.
도 3은 폴리펩티드 가닥의 도메인 및 서브 도메인 내에 돌연변이 부위를 수반한 선택된 돌연변이 변이체의 비-제한적 예를 도시한다.
도 4는 폴리펩티드 가닥 내로 치환된 상이한 도메인 및 서브 도메인을 갖는 선택된 키메라 폴리머라제 변이체의 비-제한적 예를 도시한다.
도 5a는 Φ29 폴리머라제의 엑소뉴클레아제 도메인 내의 루프 영역을 도시하는 비-제한적 예시이다.
도 5b는 Φ29 폴리머라제의 엑소뉴클레아제 영역과 다른 폴리머라제의 비-제한적 세트 간의 서열 상동성 정렬을 도시한다.
도 6은 하나 이상의 부위 특이적 돌연변이를 포함하는 키메라 폴리머라제 변이체의 비-제한적 일반적인 예를 도시한다.
도 7은 이. 콜라이(E. coli)에서 발현된 폴리머라제의 순도를 평가하기 위해 시행된 SDS-PAGE의 그림이다.
본 개시내용의 측면은 변형된 중합 효소 및 그의 조성물에 관한 것이다. 일부 측면에서, 본 개시내용은 변형된 재조합 중합 효소를 사용하는 방법 및 이러한 효소를 포함하는 조성물을 제공한다. 일부 실시양태에서, 본 개시내용은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 재조합 중합 효소 및 조성물을 제공한다. 일부 측면에서, 본원에 기재된 중합 효소는 변형된 재조합 핵산 폴리머라제, 예를 들어, 변형된 재조합 DNA 폴리머라제이다. 일부 실시양태에서, 본 개시내용에 의해 제공된 변형된 재조합 DNA 폴리머라제는 DNA의 조작 (예를 들어, DNA 시퀀싱)과 관련된 시험관내 반응을 위해 사용될 수 있다.
다른 측면 중에서, 본 개시내용은 시험관내 중합 반응을 시행하기 위해 사용될 수 있는 변형된 중합 효소 (예를 들어, 폴리머라제)를 제공한다. 일부 실시양태에서, 본원에 기재된 폴리머라제는 개별적으로 또는 조합하여, 시퀀싱 반응을 시행하는 데 유용한 하나 이상의 변형을 포함한다. 일부 실시양태에서, 본원에 기재된 변형 중 하나 이상을 활용하여, 시퀀싱 반응을 시행하는 데 유용한 하나 이상의 특성, 예를 들어, 폴리머라제 전진성, 충실도 (예를 들어, 정확도), 기질 (예를 들어, 뉴클레오시드 폴리포스페이트) 결합 친화성, 기질 활용률 (예를 들어, 뉴클레오시드 폴리포스페이트가 주형 가닥에 상보적인 성장 가닥 내로 혼입되는 비율), 변형된 기질 (예를 들어, 표지된 뉴클레오시드 폴리포스페이트)과의 폴리머라제 상호 작용, 또는 그의 일부 조합과 같은 특성을 갖는 폴리머라제를 생산할 수 있다. 일부 실시양태에서, 상기 변형 중 하나 이상은 폴리머라제의 교정 능력을 최소화하거나 또는 없앤다. 예를 들어, 일부 실시양태에서, 하나 이상의 변형은 폴리머라제의 엑소뉴클레아제 활성 상의 손실을 초래하는 폴리머라제의 엑소뉴클레아제 도메인에 대해 이루어질 수 있다.
일부 측면에서, 본 출원은 단일 분자 핵산 시퀀싱 기술에 유리한 변경된 생화학적 특성을 갖는 변형된 폴리머라제에 관한 것이다. 일부 실시양태에서, 본원에 기재된 변이체 폴리머라제는 단일 분자 시퀀싱 반응에서 개선된 시그널 판독정보를 제공하도록 변형되었다. 도 1은 실시간 시그널 판독정보와 관련하여 시퀀싱 반응의 진행을 예시하는 예를 제공한다. 이론에 얽매이고자 한 것은 아니지만, 일부 단일 분자 핵산 시퀀싱 반응은 계획 (100)에 따라서 진행되는 것으로 여겨진다.
반응의 시작에서 (패널 I), 폴리머라제 (파선)는 관찰 영역에 한정되고 주형 가닥 및 프라이머 가닥과 결합된다. 도시된 바와 같이, 상이한 유형의 검출 가능한 표지를 각각 갖는 상이한 유형의 뉴클레오티드 (예를 들어, A, G, T, C, U)가 동일한 반응 혼합물에 존재한다. 폴리머라제가 발광성 표지된 뉴클레오티드와 연합되면 (패널 II), 이러한 표지는 일정 기간 동안 관찰 영역에 한정된다. 혼입 이벤트 동안에는, 예를 들어, 이러한 기간이 상기 표지가 관찰 영역에서의 그의 존재를 검출하고 확인하기에 충분한 양의 에너지를 수용 및/또는 방출하기에 충분할 수 있다. 시그널 판독정보 (102)와 관련하여 계획 (100)의 패널 I 및 II에 의해 예시된 바와 같이, 혼입 이벤트는 펄스 폭 (pw)에 상응하는 일정 기간 동안 시그널 펄스와 연관될 수 있다.
일부 실시양태에서, 혼입 이벤트와 연관된 개별 시그널 펄스는 혼입되는 뉴클레오티드의 유형 또는 특이적 시점에서의 폴리머라제의 활성과 같은 각종 조건에 의해 영향을 받을 수 있다는 것을 인지해야 한다. 일부 실시양태에서, 개별 시그널 펄스는 약 10밀리초 내지 약 10초의 개별 펄스 폭을 가질 수 있다. 따라서, 일부 실시양태에서, 개별 펄스 폭은 비교 목적을 위한 파라미터를 제공하기 위해 평균될 수 있다. 본원에 사용된 바와 같이, 일부 실시양태에서, "펄스 폭"은 각각의 개별 시그널 펄스가 개별 펄스 폭을 갖는 복수 개의 개별 시그널 펄스의 평균에 상응하는 값을 지칭한다.
일부 실시양태에서, 본 출원의 변형된 중합 효소는 약 10밀리초 내지 약 10초의 펄스 폭을 생산한다. 일부 실시양태에서, 펄스 폭은 적어도 10밀리초 내지 10초 이하, 적어도 10밀리초 내지 5초 이하, 적어도 10밀리초 내지 1초 이하, 또는 약 10밀리초 내지 약 1초이다. 일부 실시양태에서, 펄스 폭은 약 10 내지 약 500밀리초, 약 10 내지 약 200밀리초, 약 10 내지 약 100밀리초, 약 10 내지 약 50밀리초, 약 50밀리초 내지 약 1초, 약 50 내지 약 500밀리초, 약 50 내지 약 200밀리초, 약 50 내지 약 100밀리초, 약 100밀리초 내지 약 1초, 약 100 내지 약 500밀리초, 약 100 내지 약 200밀리초, 약 200밀리초 내지 약 1초, 약 200 내지 약 500밀리초, 또는 약 500밀리초 내지 약 1초이다.
뉴클레오티드가 성장 가닥 내로 혼입되고 발광 표지가 절단된 후, 이러한 표지는 조명 용적으로부터 확산되어 관찰 영역에서 더 이상 검출 가능하지 않다 (패널 III). 또한, 패널 III에 예시된 바와 같이, 혼입 이벤트 후, 폴리머라제는 주형 가닥을 따라 진행하여 후속의 발광성 표지된 뉴클레오티드와 연합될 수 있다. 패널 I에서 패널 II로의 진행과 유사하게, 시그널 트레이스 (102)에서 패널 III에서 패널 IV로의 진행에 상응하는 시그널은 비교적 낮은 세기 수준에서부터 연합 이벤트를 표시하는 시그널 펄스로 그 세기가 증가한다. 시그널 트레이스 (102)의 관점에서, 혼입 이벤트와 후속 연합 이벤트 사이의 기간은 인터펄스 거리 (ipd)와 연관될 수 있다.
펄스 폭과 관련하여 전술한 바와 같이, 일부 실시양태에서, 제1 시그널 펄스와 제2 시그널 펄스 사이의 기간과 연관된 개별 인터펄스 거리는 특이적 시점에서의 폴리머라제의 활성 또는 전진성과 같은 각종 조건에 의해 영향을 받을 수 있다. 일부 실시양태에서, 개별 인터펄스 거리는 약 10밀리초 내지 약 1분 이상 (예를 들어, 약 1 내지 약 60초, 약 1 내지 약 30초, 약 1 내지 약 20초, 약 1 내지 약 10초, 또는 약 1초 미만)의 기간에 상응한다. 따라서, 일부 실시양태에서, 개별 인터펄스 거리는 비교 목적을 위한 파라미터를 제공하기 위해 평균될 수 있다. 본원에 사용된 바와 같이, 일부 실시양태에서, "인터펄스 거리"는 복수 개의 개별 인터펄스 거리의 평균에 상응하는 값을 지칭한다.
일부 실시양태에서, 본 출원의 변형된 중합 효소는 약 10밀리초 내지 약 10초의 인터펄스 거리를 초래한다. 일부 실시양태에서, 인터펄스 거리는 적어도 10밀리초 내지 10초 이하, 적어도 10밀리초 내지 5초 이하, 적어도 10밀리초 내지 1초 이하, 또는 약 10밀리초 내지 약 1초이다. 일부 실시양태에서, 인터펄스 거리는 약 10 내지 약 500밀리초, 약 10 내지 약 200밀리초, 약 10 내지 약 100밀리초, 약 10 내지 약 50밀리초, 약 50밀리초 내지 약 1초, 약 50 내지 약 500밀리초, 약 50 내지 약 200밀리초, 약 50 내지 약 100밀리초, 약 100밀리초 내지 약 1초, 약 100 내지 약 500밀리초, 약 100 내지 약 200밀리초, 약 200밀리초 내지 약 1초, 약 200 내지 약 500밀리초, 또는 약 500밀리초 내지 약 1초이다.
펄스 폭 및/또는 인터펄스 거리의 특징은, 일부 실시양태에서, 특이적 발광 표지를 확인하기 위해 사용될 수 있다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 주형 가닥의 뉴클레오티드 서열을 결정하기 위해 발광성 표지된 뉴클레오티드의 연합을 표시하는 일련의 펄스 폭을 관찰함으로써 시퀀싱 반응에 사용될 수 있다. 일부 실시양태에서, 이러한 프로세스에서의 인공물은 부정확한 시퀀싱 정보를 야기할 수 있다. 예를 들어, 패널 V는 발광성 표지된 뉴클레오티드가 시그널 펄스를 발생시키기에 충분한 기간 동안 관찰 영역에 한정되지만 혼입 이벤트가 없는 결합 및 방출 이벤트를 예시한다.
패널 V에 제시된 바와 같이, 패널 IV에서 검출된 혼입 후에, 절단된 발광 표지는 관찰 가능한 영역 밖으로 확산한다 (i). 추가로 발광성 표지된 뉴클레오티드는 관찰 가능한 영역에서 폴리머라제와 연합하여 검출 가능한 시그널을 발생시킨다 (ii). 성장 가닥 내로 혼입되기 보다는, 발광성 표지된 뉴클레오티드가 폴리머라제로부터 해리되어 다시 반응 혼합물 내로 확산된다 (iii). 따라서, 동일한 유형의 뉴클레오티드의 후속적으로 성공적인 혼입 후 (도시되지 않음), 패널 V에 상응하는 시그널 펄스는 시퀀싱 정보 판독에 명백한 삽입을 초래할 것이다. 따라서, 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 이들 및 다른 인공물 이벤트로부터의 진실한 혼입 이벤트를 판별하기에 충분한 길이의 펄스 폭을 갖는다. 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 폴리머라제 활성 부위로부터의 조기 기질 방출 가능성을 감소시키는 하나 이상의 변형을 갖는다. 일부 실시양태에서, 본 출원의 변형된 폴리머라제는 일단 기질이 폴리머라제 활성 부위와 연합되면 기질 혼입의 가능성을 증가시키는 하나 이상의 변형을 갖는다.
일부 실시양태에서, 본 개시내용에 의해 제공된 변형된 폴리머라제는 하나 이상의 변형을 수반한 표 1에 제시된 야생형 폴리머라제 서열 [서열식별번호 (SEQ ID NO): 1-19]에 따르는 폴리머라제 서열을 포함한다 (예를 들어, 표 2-5에 예시된 바와 같거나, 또는 그의 2개 이상의 조합).
<표 1>
야생형 폴리머라제 아미노산 서열
Figure pat00001
Figure pat00002
Figure pat00003
Figure pat00004
Figure pat00005
일부 실시양태에서, 야생형 폴리머라제 서열 (예를 들어, 표 1에 제시된 바와 같음)은 하나 이상의 변형이 재조합 변이체 폴리머라제를 생성하기 위해 만들어질 수 있는 대다수의 폴리머라제 서열을 제공한다. 본원에 사용된 바와 같이, 변형된 폴리머라제의 "대다수의 폴리머라제 서열" 또는 "대다수의 서열"은 변형된 폴리머라제 서열 내에서 우세한 야생형 폴리머라제 서열을 지칭한다 (예를 들어, 변형된 폴리머라제 내의 아미노산의 적어도 50%가 대다수의 서열 내의 아미노산에 상응한다). 일부 실시양태에서, 변형된 폴리머라제 서열은 하나 이상의 아미노산 돌연변이를 추가로 포함하는 대다수의 서열을 포함한다. 일부 실시양태에서, 하나 이상의 아미노산 돌연변이는 상동 단백질 내의 위치에 상응하는 위치에 아미노산을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 A484에 상응하는 위치에 돌연변이를 포함한다. 다른 폴리머라제 내의 A484에 상응하는 아미노산은 상동성 정렬을 포함하여 관련 기술분야에 공지된 임의의 방법에 의해 결정될 수 있다. 이러한 분석의 비-제한적 예로서, 상동성 정렬은 표 1에 보고된 수많은 폴리머라제를 사용하여 시행되었으며, Φ29 폴리머라제 내의 A484가 M2Y 내의 A481, 바실루스(Bacillus) 파지 VMY22 내의 A492, 엔테로코쿠스 파에시움(Enterococcus faecium) 내의 K500, 및 루실리아 쿠프리나(Lucilia cuprina) 내의 K827에 상응하는 것으로 결정되었다. 따라서, 상동성 정렬 및 관련 기술분야에 공지된 유사한 방법을 사용하여, 본원에 기재된 변형된 잔기의 위치에 상응하는 다른 폴리머라제 내의 아미노산을 확인할 수 있다. 따라서, 본 개시내용의 변형이 본원에 기재된 폴리머라제 (예를 들어, 표 1에 열거된 것)로 제한하려는 것이 아니고, 공지된 기술을 사용하여 임의의 중합 효소로 연장될 수 있다는 것을 인지해야 한다.
일부 실시양태에서, 변형된 폴리머라제는 표 1에 열거된 폴리머라제 중 하나 이상 (예를 들어, 서열식별번호: 1, 서열식별번호: 5, 또는 표 1에 열거된 다른 서열)에 대해 적어도 25% 아미노산 서열 동일성을 갖는다. 일부 실시양태에서, 변형된 폴리머라제는 표 1에 열거된 폴리머라제 중 하나 이상 (예를 들어, 서열식별번호: 1, 서열식별번호: 5, 또는 표 1에 열거된 다른 서열)에 대해 25-50%, 50-60%, 60-70%, 70-80%, 80-90%, 90-95%, 또는 95-99%, 또는 그 초과의 아미노산 서열 동일성을 갖는다. 일부 실시양태에서, 이러한 변형된 폴리머라제는 본 출원에 제공된 상이한 변형된 폴리머라제 입체 배치 및/또는 예의 문맥에서 기재된 아미노산 돌연변이 및/또는 도메인 치환 중 하나 이상을 포함한다.
일부 실시양태에서, 상이한 폴리머라제로부터의 하나 이상의 절편 또는 영역은 본 출원에 기재된 특이적 서열에 대해 적어도 80% 아미노산 서열 동일성을 갖는 것으로 기재된다. 이러한 영역은, 예를 들어, 명시된 서열 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 상응하는 절편 또는 영역)에 대해 80-90%, 90-95%, 95-99%, 또는 100% 서열 동일성을 가질 수 있다. 또한, 대체 실시양태에서, 이러한 절편 영역은 명시된 서열 (예를 들어, 표 1의 자연 발생 폴리머라제 내의 상응하는 절편 또는 영역)에 대해 더 낮은 서열 동일성 (예를 들어, 50-60%, 60-70%, 또는 70-80%)의 아미노산 서열 동일성을 가질 수 있다.
2개 이상의 아미노산 서열을 비교할 목적으로, 제1 아미노산 서열과 제2 아미노산 서열 간의 "서열 동일성" (본원에서 "아미노산 동일성"으로서 지칭되기도 함)의 백분율은 [제2 아미노산 서열 내의 상응하는 위치에서의 아미노산 잔기와 동일한 제1 아미노산 서열 내의 아미노산 잔기의 수]를 [제1 아미노산 서열 내의 아미노산 잔기의 총 수]로 나누고 이에 [100%]를 곱합으로써 계산될 수 있으며, 여기서 제1 아미노산 서열과 비교해서 제2 아미노산 서열 내의 아미노산 잔기의 각각의 결실, 삽입, 치환 또는 부가는 단일 아미노산 잔기 (위치)에서의 차이로서 간주되는데, 즉 본원에 정의된 바와 같은 "아미노산 차이"로서 간주된다. 또 다른 한편으로, 두 아미노산 서열 간의 서열 동일성의 정도는 공지된 컴퓨터 알고리즘을 이용하여, 예를 들어, 문헌 [Smith and Waterman (1970) Adv. Appl. Math. 2:482c]의 국소 상동성 알고리즘에 의해, 문헌 [Needleman and Wunsch, J. Mol. Biol. (1970) 48:443]의 상동성 정렬 알고리즘에 의해, 문헌 [Pearson and Lipman. Proc. Natl. Acad. Sci. USA (1998) 85:2444]의 유사성 검색 방법에 의해, 또는 블라스트(Blast), 클러스털 오메가(Clustal Omega), 또는 다른 서열 정렬 알고리즘으로서 이용 가능한 알고리즘의 컴퓨터화된 구현에 의해, 및 예를 들어, 표준 설정을 이용하여 계산될 수 있다. 통상적으로, 상기 그 개요가 서술된 계산 방법에 따라 두 아미노산 서열 간의 "서열 동일성"의 백분율을 결정할 목적으로, 가장 많은 수의 아미노산 잔기를 갖는 아미노산 서열이 "제1" 아미노산 서열로서 간주될 것이고, 다른 아미노산 서열이 "제2" 아미노산 서열로서 간주될 것이다.
부가적으로, 또는 또 다른 한편으로, 2개 이상의 서열은 서열 간의 동일성에 관하여 평가될 수 있다. 2개 이상의 핵산 또는 아미노산 서열의 문맥에서 용어 "동일한" 또는 퍼센트 "동일성"은 동일한 2개 이상의 서열 또는 하위 서열을 지칭한다. 2개의 서열이 하기 서열 비교 알고리즘 중 하나를 이용하거나 또는 수동 정렬 및 육안 검사에 의해 측정된 바와 같이 비교 창 또는 지명된 영역에 걸쳐 최대 상응도를 위해 비교 및 정렬되는 경우, 명시된 영역에 걸쳐 또는 전체의 서열에 걸쳐 동일한 아미노산 잔기 또는 뉴클레오티드의 명시된 백분율 (예를 들어, 적어도 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.6%, 99.7%, 99.8% 또는 99.9% 동일함)을 갖는 경우에 이러한 2개의 서열은 "실질적으로 동일하다". 임의로, 동일성은 적어도 약 25, 50, 75, 또는 100개 아미노산의 길이인 영역에 걸쳐, 또는 보다 바람직하게 100 내지 150, 200개 또는 그 초과의 아미노산의 길이인 영역에 걸쳐 존재한다.
부가적으로, 또는 또 다른 한편으로, 2개 이상의 서열은 서열 간의 정렬에 관하여 평가될 수 있다. 2개 이상의 핵산 또는 아미노산 서열의 문맥에서 용어 "정렬" 또는 퍼센트 "정렬"은 동일한 2개 이상의 서열 또는 하위 서열을 지칭한다. 2개의 서열이 하기 서열 비교 알고리즘 중 하나를 이용하거나 또는 수동 정렬 및 육안 검사에 의해 측정된 바와 같이 비교 창 또는 지명된 영역에 걸쳐 최대 상응도를 위해 비교 및 정렬되는 경우, 명시된 영역에 걸쳐 또는 전체의 서열에 걸쳐 동일한 아미노산 잔기 또는 뉴클레오티드의 명시된 백분율 (예를 들어, 적어도 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99%, 99.5%, 99.6%, 99.7%, 99.8% 또는 99.9% 동일함)을 갖는 경우에 이러한 2개의 서열은 "실질적으로 정렬된다". 임의로, 정렬은 적어도 약 25, 50, 75, 또는 100개 아미노산의 길이인 영역에 걸쳐, 또는 보다 바람직하게 100 내지 150, 200개 또는 그 초과의 아미노산의 길이인 영역에 걸쳐 존재한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 K131, K135, L142, Y148, Y224, E239, V250, L253, R306, R308, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 위치에 하나 이상 (예를 들어, 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하는 경우, 이러한 변형된 폴리머라제는 앞서 열거된 바와 같은 위치에 하나 이상의 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 Y148, Y226, V250, N251, T368, E375, K379, Q380, A437, P477, K478, 및 A484에 상응하는 하나 이상의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Y148, Y226, V250, N251, T368, E375, K379, Q380, A437, P477, K478, 및 A484 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484C 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484S 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484T 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484Q 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484N 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484E 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484D 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484K 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484R 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484H 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484Y 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Y148I, Y226F, V250A, N251R, T368F, E375K, K379R, Q380R, A437G, P477D, K478D, 및 A484X 중 하나 이상을 포함하며, 여기서 X는 본원에 기재된 바와 같은 비-자연 아미노산을 나타낸다. 본원에 사용된 바와 같은, 하나 이상은 상기 열거된 아미노산 치환 중 2개 이상, 4개 이상, 6개 이상, 8개 이상, 10개 이상, 12개 이상, 예를 들어 모두일 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M8, V51, N62, I71, L107, K131, K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 하나 이상의 위치 (예를 들어, 1 내지 35개 위치 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)에 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M8, V51, N62, I71, L107, K131, K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 하기 돌연변이 M8R, V51A, N62D, I71V, L107I, K131E, K135Q, L142K, G197D, Y224K, E239G, V250A, V250I, L253A, L253H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K, D510R, K512Y, E515Q, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1 내지 35개 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 20개 이상, 예를 들어 모두)을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 K135, L142, Y224, E239, V250, L253, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571에 상응하는 하나 이상의 위치 (예를 들어, 1 내지 18개의 위치 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 예를 들어 모두)에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 K135, L142, Y224, E239, V250, L253, E375, A437, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 K135Q, L142K, Y224K, E239G, V250I, L253A, E375Y, A437G, E466K, D476H, A484E, E508R, D510R, K512Y, E515Q, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1 내지 18개 또는 그 사이의 임의의 정수, 예를 들어 2개 이상, 5개 이상, 10개 이상, 15개 이상, 예를 들어 모두)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 TPR1 영역 치환을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 S260-L359에 상응하는 TPR1 영역 대신 이. 파에시움으로부터의 TPR1 영역 (예를 들어, 서열식별번호: 5 내의 V271-M375)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 치환을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 M1-V54에 상응하는 아미노산 대신 M2Y로부터의 엑소뉴클레아제 영역의 부분 (예를 들어, 서열식별번호: 2 내의 M1-I51)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 E75-N91에 상응하는 아미노산 대신 이. 파에시움으로부터의 엑소뉴클레아제 영역의 부분 (예를 들어, 서열식별번호: 5 내의 F72-S89)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M1-V54 및 E75-N91에 각각 상응하는 아미노산 대신 M2Y로부터의 엑소뉴클레아제 영역의 부분 및 이. 파에시움으로부터의 엑소뉴클레아제 영역의 부분을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 변형된 팜 영역을 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 (서열식별번호: 1) 내의 M429-I433에 상응하는 아미노산 대신 이. 파에시움으로부터의 팜 영역의 부분 (예를 들어, 서열식별번호: 5 내의 L445-V449)을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 A444에 상응하는 위치에 알라닌에서 티민으로의 돌연변이 (예를 들어, A444T)를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 이. 파에시움으로부터의 팜 영역의 부분 및 Φ29 폴리머라제 내의 A444T에 상응하는 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 G197, I71, 및 L107에 상응하는 하나 이상의 위치 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 G197, I71, 및 L107 중 하나 이상 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 G197D, I71V, 및 L107I 중 하나 이상 (예를 들어, 1, 2, 또는 3개)을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 폴리머라제의 하나 이상의 영역 또는 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) 내의 하나 이상의 아미노산 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 엑소뉴클레아제 영역, 팜 영역, TPR1 영역, 핑거 영역, TPR2 영역, 및 섬 영역 중 하나 이상 내의 하나 이상의 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 위치 (예를 들어, 엑소뉴클레아제 영역의 엑소뉴클레아제 루프)에 돌연변이를 포함한다. 일부 실시양태에서, Φ29 폴리머라제 대다수의 서열을 갖는 변형된 폴리머라제는 엑소뉴클레아제 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Φ29 폴리머라제의 엑소뉴클레아제 영역 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91 중 하나 이상에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91에 상응하는 위치에 하나 이상의 아미노산 돌연변이를 포함한다. 따라서, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 E75F, R76K, S82C, A83K, D84E, G85A, L86K, P87E, N88R, Y90F, 및 N91S 중 하나 이상을 포함한다. 따라서, 일부 실시양태에서, 엑소뉴클레아제 도메인 또는 그의 부분을 포함하는 절편은 상이한 폴리머라제로부터의 상응하는 엑소뉴클레아제 도메인에 대해 교환된다. 예를 들어, 일부 실시양태에서, 하나의 폴리머라제의 엑소뉴클레아제 도메인의 플랭킹 아미노산 및 루프를 포함하는 절편은 또 다른 폴리머라제로부터의 상응하는 절편으로 대체된다. 예를 들어, 일부 실시양태에서, Φ29 E75-N91 절편은 이. 파에시움으로부터의 상응하는 F72-S89 절편으로 대체된다. 일부 실시양태에서, 엑소뉴클레아제 루프를 포함하는 절편을 교환하는 것은 폴리머라제의 인터펄스 거리를 감소시킬 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 TPR1 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 Y281, I288, T301, D325, D341, 및 K354에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Y281, I288, T301, D325, D341, 및 K354 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, Y281, I288, T301, D325, D341, 및 K354 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)에서의 아미노산은 다른 폴리머라제 (예를 들어, M2Y, 루실리아 쿠프리나, 바실루스 균주, 예를 들어 GA-1) 내의 상응하는 위치에서의 아미노산으로 변화된다. 일부 실시양태에서, 변형된 폴리머라제는 Y281H, I288L, T301C, D325E, D341E, 및 K354R 중 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 Y281, I288, T301, D325, D341, 및 K354에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 또는 6개)의 위치에서의 돌연변이는 (예를 들어, 단일 분자 시퀀싱 반응에서의) 혼입 속도를 증가시킨다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 M429, G430, V431, I433, 및 A444에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 M429, G430, V431, I433, 및 A444 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, M429, G430, V431, I433, 및 A444 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에서의 아미노산은 다른 폴리머라제 (예를 들어, M2Y, 루실리아 쿠프리나, 바실루스 균주, 예를 들어 GA-1) 내의 상응하는 위치에서의 아미노산으로 변화된다. 일부 실시양태에서, 변형된 폴리머라제는 M429L, G430A, V431S, I433V, 및 A444T 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 M429, G430, V431, I433, 및 A444에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에서의 돌연변이는 (예를 들어, 단일 분자 시퀀싱 반응에서의) 정확도를 증가시킨다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치 및 엑소뉴클레아제 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 G197, M8, 및 V51에 상응하는 하나 이상 (예를 들어, 1, 2, 또는 3개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 G197, M8, 및 V51 중 하나 이상 (예를 들어, 1, 2, 또는 3개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 G197D, M8R, 및 V51A 중 하나 이상 (예를 들어, 1, 2, 또는 3개)을 포함한다. 일부 실시양태에서, Φ29 폴리머라제 내의 G197, M8, 및 V51에 상응하는 하나 이상 (예를 들어, 1, 2, 또는 3개)의 위치에서의 돌연변이는 생산 수율, 열 안정성을 개선시키고/시키거나 부하 (예를 들어, 어레이의 샘플 웰 내로의 부하)의 효율을 개선시킬 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 팜 영역 내의 하나 이상의 위치 및 섬 영역 내의 하나 이상의 위치에 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E466, D476, K539, D570, 및 T571에 상응하는 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)의 위치에 돌연변이를 포함한다. 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 E466, D476, K539, D570, 및 T571 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)에 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 E466K, D476H, K539E, D570S, 및 T571V 중 하나 이상 (예를 들어, 1, 2, 3, 4, 또는 5개)을 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 M2Y 폴리머라제 내의 N59, Y145, V247, L250, E372, A481, 및 K509에 상응하는 위치에 하나 이상 (예를 들어, 1, 2, 3, 4, 5, 6, 또는 7개)의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 M2Y 폴리머라제 대다수의 서열을 포함하는 경우, 이러한 변형된 폴리머라제는 앞에 열거된 바와 같은 위치에 하나 이상의 돌연변이를 포함한다. 일부 실시양태에서, 변형된 폴리머라제가 M2Y 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산 돌연변이를 포함한다.
일부 실시양태에서, 변형된 폴리머라제는 야생형 폴리머라제 (예를 들어, 표 1에 제시된 바와 같음)의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)을 포함한다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) (예를 들어, 서열식별번호: 5의 하나 이상의 절편)이 서열식별번호: 1-4, 및 6-19 중 임의의 것의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 Φ29 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 M2Y 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 Φ29 폴리머라제 및/또는 M2Y 폴리머라제의 하나 이상의 절편을 대체할 수 있다. 일부 실시양태에서, 엔테로코쿠스 파에시움 폴리머라제의 하나 이상의 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분) (예를 들어, 서열식별번호: 5의 도메인 또는 그의 변형된 형태, 예를 들어, 하나 이상의 아미노산 치환을 함유함)이 본원에 기재된 변이체 폴리머라제 (예를 들어, 표 2에 열거된 변이체 폴리머라제, 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 아미노산 치환 또는 다른 도메인 치환을 함유하는 변이체 폴리머라제)의 하나 이상의 절편을 대체할 수 있다.
일부 실시양태에서, 변형된 폴리머라제의 대다수의 서열은 예로서 상기 열거된 폴리머라제 내의 위치에 상응하는 하나 이상의 상동 아미노산을 포함하지 않는다. 이러한 경우, 일부 실시양태에서, 변형된 폴리머라제는 하나 이상의 돌연변이를 포함하지 않는다. 그러나, 일부 실시양태에서, 원하는 아미노산 서열을 본원에 기재된 폴리머라제 서열과 비교할 때 주변 상동 잔기가 확인 가능한 경우, 돌연변이된 아미노산은 상기 주변 상동 잔기에 기초하여 추론되는 폴리머라제 내의 특정 부위에서의 삽입으로서 상기 변형된 폴리머라제에 포함된다. 돌연변이된 폴리머라제 변이체는 본원에 기재된 실시양태에 따라서 조작되었고 표 2에 열거된다 (서열식별번호: 20-96).
<표 2>
상동 폴리머라제 변이체
Figure pat00006
Figure pat00007
Figure pat00008
Figure pat00009
Figure pat00010
Figure pat00011
Figure pat00012
Figure pat00013
Figure pat00014
Figure pat00015
Figure pat00016
Figure pat00017
Figure pat00018
Figure pat00019
Figure pat00020
일부 실시양태에서, 아미노산은 폴리머라제의 구조 및/또는 기능에 기초하여 변형을 위해 선택된다. 예를 들어, 도 2는 Φ29 폴리머라제 (200)의 카툰 예시를 도시한다. 폴딩된 3차원 구조는 오버레이 (202)에 상응하는 별개의 도메인 및 서브 도메인을 포함한다: N-말단 엑소뉴클레아제 도메인 (1); 및 팜 서브 도메인 (2), 말단 단백질 영역 1 서브 도메인 (TPR1) (3), 핑거 서브 도메인 (4), TPR2 서브 도메인 (5), 및 섬 서브 도메인 (6)을 함유하는 C-말단 폴리머라제 도메인. 이들 도메인 및 서브 도메인은 N-말단에서 C-말단 방식으로 배향되는, 폴리펩티드 구축물 (204)에 따르는 폴리펩티드 가닥의 부위에 매핑된다. 도시된 바와 같이, N-말단 엑소뉴클레아제 도메인 (1)은 야생형 Φ29 폴리머라제의 잔기 1-189에 걸쳐 있고, C-말단 폴리머라제 도메인은 잔기 190-575에 걸쳐 있다. C-말단 폴리머라제 도메인 내에서, 팜 서브 도메인 (2)은 야생형 Φ29 폴리머라제의 잔기 190-260 및 427-530에 걸쳐 있고, TPR1 서브 도메인 (3)은 잔기 261-358에 걸쳐 있으며, 핑거 서브 도메인 (4)은 잔기 359-394에 걸쳐 있고, TPR2 서브 도메인 (5)은 잔기 395-426에 걸쳐 있으며, 섬 서브 도메인 (6)은 잔기 531-575에 걸쳐 있다. 본 출원에 기재된 상이한 폴리머라제의 등가 절편 (예를 들어, 플랭킹 아미노산을 임의로 포함한, 도메인 또는 그의 부분)이 서로 대체되어 키메라 폴리머라제를 생산할 수 있다. 예를 들어, 하나의 폴리머라제 (예를 들어, 표 1에 제시된 야생형 서열을 갖거나 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 돌연변이를 갖는다)로부터의 엑소뉴클레아제 도메인, 팜 서브 도메인, TPR1 서브 도메인, 하나 이상의 핑거 서브 도메인, TPR2 서브 도메인, 및/또는 섬 서브 도메인 중 하나 이상이 또 다른 폴리머라제 (예를 들어, 표 1에 제시된 야생형 서열을 갖거나 또는 표 2에 예시되거나 또는 표 3-5에 기재된 하나 이상의 돌연변이를 갖는다) 내의 상응하는 도메인을 대체할 수 있다. 일부 실시양태에서, 하나 이상의 플랭킹 아미노산을 임의로 포함한, 이들 도메인 중 하나 이상의 부분을 포함하는 절편이 대체할 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 이외의 대다수의 폴리머라제 서열을 포함한다. 이러한 실시양태에서, 대다수의 폴리머라제 서열은 (예를 들어, 상동성 정렬, 계산 모델링, 구조적 분석, 또는 임의의 적합한 방법에 기초하여) Φ29 폴리머라제 (200)로 유추될 수 있는 하나 이상의 영역을 포함한다. 본원에 사용된 바와 같은, 폴리머라제의 "영역"은 폴리머라제 효소의 별개의 도메인 또는 서브 도메인을 지칭한다. 예를 들어, 일부 실시양태에서, 폴리머라제의 영역은 N-말단 엑소뉴클레아제 도메인 또는 C-말단 폴리머라제 도메인을 지칭한다. 일부 실시양태에서, 폴리머라제의 영역은 팜 서브 도메인, TPR1 서브 도메인, 핑거 서브 도메인, TPR2 서브 도메인, 또는 섬 서브 도메인을 지칭한다. 따라서, 일부 실시양태에서, 폴리머라제의 영역은 소정의 도메인 또는 서브 도메인을 포함하는 모든 아미노산을 지칭한다. 일부 실시양태에서, 변형된 폴리머라제는 대다수의 폴리머라제 서열의 하나 이상의 영역에 대한 변형을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 대다수의 폴리머라제 서열의 하나 이상의 부분에 대한 변형을 포함한다. 본원에 사용된 바와 같은, 폴리머라제의 "부분"은 폴리머라제 서열 내의 2개 이상의 연속되는 잔기의 연장물을 지칭한다. 일부 실시양태에서, 폴리머라제 서열의 부분은 단일 폴리머라제 도메인 또는 단일 폴리머라제 서브 도메인 내의 2개 이상의 연속되는 아미노산을 지칭한다. 일부 실시양태에서, 폴리머라제 서열의 부분은 2개 이상의 폴리머라제 도메인 및/또는 서브 도메인 전역에 걸쳐 있는 2개 이상의 연속되는 아미노산을 지칭한다. 따라서, 일부 실시양태에서, 폴리머라제 서열의 부분은 폴리머라제 서열 이내의 연속되는 아미노산의 임의의 연장물이다. 일부 실시양태에서, 부분은 5-10개의 연속되는 아미노산, 10-25개의 연속되는 아미노산, 25-50개의 연속되는 아미노산, 50-75개의 연속되는 아미노산, 75-100개의 연속되는 아미노산 또는, 예를 들어, 폴리머라제 영역 또는 도메인의 부분을 구성하는 다른 수의 연속되는 아미노산을 지칭한다.
일부 실시양태에서, 변형된 폴리머라제는 일반적으로 도 2에 도시된 바와 같은 도메인 및/또는 서브 도메인 중 하나 이상 내에서의 하나 이상의 단일 부위 돌연변이를 포함한다. 예를 들어, 도 3은 각각의 폴리펩티드 가닥 이내의 돌연변이 부위 (화살표로 그 근차치가 제시됨)를 수반한 표 2의 선택된 돌연변이 변이체를 도시한다. M2Y 및 M2Y 돌연변이 변이체 H016 (열린 채움), 루실리아 쿠프리나 및 루실리아 쿠프리나 돌연변이 변이체 H018 (점자 채움), 엔테로코쿠스 파에시움 및 엔테로코쿠스 파에시움 돌연변이 변이체 H020 (파선 채움), 및 바실루스 파지 VMY22 및 바실루스 파지 VMY22 돌연변이 변이체 H022 (대각선 채움)에 대한 폴리펩티드 가닥이 도시된다. 그러나, 본원에 기재된 바와 같은 다른 절편 교환 및/또는 아미노산 돌연변이를 포함하는 키메라가 사용될 수도 있다.
일부 실시양태에서, 본원에 기재된 하나 이상의 단일 부위 돌연변이 변형 이외에 또는 그에 대한 대안으로, 대다수의 폴리머라제 서열 내의 아미노산의 연장물 (예를 들어, 2개 이상의 연속되는 아미노산)이 변형된다. 일부 실시양태에서, 아미노산의 연장물은 상이한 폴리머라제 서열의 부분에 상응하는 아미노산의 연장물이다. 예를 들어, 일부 실시양태에서, 대다수의 폴리머라제 서열의 도메인/서브 도메인 (또는 그 내에서의 부분)은 상이한 폴리머라제 서열의 상응하는 도메인/서브 도메인 (또는 그 내에서의 부분)으로 교환된다. 이러한 실시양태에서, 폴리머라제는 키메라 폴리머라제, 키메라 폴리머라제 변이체, 또는 키메라로서 지칭된다. 키메라 폴리머라제는 본원에 기재된 실시양태에 따라서 조작되었고, 표 3에 열거된다 (서열식별번호: 97-516).
<표 3>
키메라 폴리머라제 변이체
Figure pat00021
Figure pat00022
Figure pat00023
Figure pat00024
Figure pat00025
Figure pat00026
Figure pat00027
Figure pat00028
Figure pat00029
Figure pat00030
Figure pat00031
Figure pat00032
Figure pat00033
Figure pat00034
Figure pat00035
Figure pat00036
Figure pat00037
Figure pat00038
Figure pat00039
Figure pat00040
Figure pat00041
Figure pat00042
Figure pat00043
Figure pat00044
Figure pat00045
Figure pat00046
Figure pat00047
Figure pat00048
Figure pat00049
Figure pat00050
Figure pat00051
Figure pat00052
Figure pat00053
Figure pat00054
Figure pat00055
Figure pat00056
Figure pat00057
Figure pat00058
Figure pat00059
Figure pat00060
Figure pat00061
Figure pat00062
Figure pat00063
Figure pat00064
Figure pat00065
Figure pat00066
Figure pat00067
Figure pat00068
Figure pat00069
Figure pat00070
Figure pat00071
Figure pat00072
Figure pat00073
Figure pat00074
Figure pat00075
Figure pat00076
Figure pat00077
Figure pat00078
Figure pat00079
Figure pat00080
Figure pat00081
Figure pat00082
Figure pat00083
Figure pat00084
Figure pat00085
Figure pat00086
Figure pat00087
Figure pat00088
Figure pat00089
Figure pat00090
Figure pat00091
Figure pat00092
Figure pat00093
Figure pat00094
Figure pat00095
Figure pat00096
Figure pat00097
Figure pat00098
Figure pat00099
Figure pat00100
Figure pat00101
일부 실시양태에서, 본 개시내용의 변형된 재조합 폴리머라제 효소는 표 3으로부터 선택된다. 일부 실시양태에서, 키메라 폴리머라제 변이체 (예를 들어, 표 3에 열거된 바와 같음)는 상이한 폴리머라제 서열의 영역 또는 부분으로 치환된 대다수의 서열의 영역 또는 부분을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 대다수의 폴리머라제 서열 내의 영역 (예를 들어, 도메인 및/또는 서브 도메인)을 포함하는 잔기 모두는 상이한 폴리머라제 서열 내의 상응하는 영역을 포함하는 잔기 모두로 치환된다. 일부 실시양태에서, 대다수의 폴리머라제 서열 내의 영역을 포함하는 잔기의 적어도 특정 부분은 상이한 폴리머라제 서열 내의 상응하는 영역을 포함하는 잔기의 적어도 특정 부분으로 치환된다.
일부 실시양태에서, 대다수의 서열 내의 단일 서브 도메인 만이 상이한 서열의 상응하는 서브 도메인으로 치환된다. 예를 들어, 도 4는 표 3으로부터 선택된 키메라 폴리머라제 변이체를 도시한다. 6개의 선택된 변이체가, 아미노 말단에서 카르복시 말단 배향으로 폴리펩티드 이내에 일반적으로 발생하는 바와 같이 서브 도메인을 갖는 폴리펩티드 가닥으로서 제시된다. 도 4의 폴리펩티드 가닥 각각은 Q001의 폴리머라제 대다수의 서열 (흑색 채움)을 포함하며, 하나 이상의 도메인 및/또는 서브 도메인이 M2Y 폴리머라제 (서열식별번호: 2, 열린 채움)의 하나 이상의 상응하는 도메인 및/또는 서브 도메인 또는 루실리아 쿠프리나 (서열식별번호: 3, 점자 채움)의 하나 이상의 상응하는 도메인 및/또는 서브 도메인 및/또는 하나 이상의 플랭킹 아미노산으로 치환된다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 도 4에 도시된 바와 같이, C017은 M2Y 폴리머라제 서열 (예를 들어, 서열식별번호: 2에 제시된 바와 같음)로부터 치환된 엑소뉴클레아제 도메인을 포함하는 키메라 폴리머라제 변이체이다. 유사하게, C020은 루실리아 쿠프리나 폴리머라제 서열 (예를 들어, 서열식별번호: 3에 제시된 바와 같음)로부터 치환된 엑소뉴클레아제 도메인을 포함한다. 일부 실시양태에서, 변형된 폴리머라제 변이체 내의 엑소뉴클레아제 도메인의 변형 또는 대체는 폴리머라제의 교정 능력이 바람직하지 않은 경우 (예를 들어, 시퀀싱 반응에서)에 유용할 수 있다. 그러나, 부가의 및 대안 도메인 및/또는 서브 도메인 치환이 본 개시내용의 변형된 재조합 폴리머라제를 위해 고려된다는 것을 인지해야 한다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 루프를 갖는 대다수의 폴리머라제 서열을 포함한다. 본원에 사용된 바와 같은, 일부 실시양태에서, "엑소뉴클레아제 루프"는 엑소뉴클레아제 도메인 내에 루프 영역을 형성하는 연속되는 아미노산의 연장물을 지칭한다. 예를 들어, 도 5a는 전체 투시도 (500) 및 확대 투시도 (502)에서의 Φ29 폴리머라제의 카툰 예시를 도시한다. 전체 투시도 (500)로 도시된 박스 내에 있는 영역의 확대도인 확대 투시도 (502)는 Φ29 폴리머라제의 엑소뉴클레아제 도메인 내의 루프 영역을 나타낸다. 선택된 루프 잔기는 잔기 N77 내지 N88에 걸쳐 있는 엑소뉴클레아제 루프를 형성하는 연속되는 아미노산의 연장물과 함께 확대 투시도 (502)의 스틱 형태로 도시된다. 이러한 엑소뉴클레아제 도메인의 영역에 대한 진화 보존 분석 결과, 루프 및 몇 개의 플랭킹 잔기가 비교적 잘 보존되지 않은 것으로 밝혀졌다. 도 5b는 Φ29 폴리머라제의 엑소뉴클레아제 영역과 표 1로부터 선택된 다른 폴리머라제의 비-제한적 세트 간의 상동성 정렬 (504)을 도시한다. 또한, Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88 및 다른 폴리머라제 내의 상응하는 엑소뉴클레아제 루프를 보여주는 루프 상동성 정렬 (506)이 도시된다.
Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88에 상응하는 영역 내에서 비교적 낮은 보존성을 보여주는 상동성 분석에 기초하여, 이는 폴리머라제 변이체에서 바람직한 생화학적 특성 (예를 들어, 시퀀싱 반응에서 사용하기에 바람직하다)에 대한 검색에서 변이 공급원을 제공하였다. 따라서, 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 엑소뉴클레아제 루프를 갖는 대다수의 폴리머라제 서열을 포함하며, 여기서 "엑소뉴클레아제 루프"는 Φ29 폴리머라제의 엑소뉴클레아제 루프 N77-N88과 상동이다 (예를 들어, 도 5b 내의 루프 상동성 정렬 (506)에 의해 도시된 바와 같음).
도 5b 내의 예시적인 정렬에 의해 도시된 바와 같이, 서열 상동성 분석은 Φ29 폴리머라제의 N77-N88과 상동인 엑소뉴클레아제 루프 서열을 확인하기 위해 사용될 수 있다. 한 예로서 제한 없이, 루프 상동성 정렬 (506)은 M2Y (H74-N85), 루실리아 쿠프리나 (N64-G76), 이. 파에시움 (N74-R86), 바실루스 GA-1 (N74-K88), 바실루스 VMY22 (K80-K91), 악티노마이세스(Actinomyces) AV-1 (H93-K105), 감자 낭 선충류 (L86-K99), 이베리아 스라소니 내장(Iberian lynx gut) (D73-R87), 칸디다투스(Candidatus) (N85-N98), 및 에게르텔라 종(Eggerthella sp.) (V73-K88)에 대한 상동 엑소뉴클레아제 루프 서열을 나타낸다. 따라서, 일부 실시양태에서, 치환된 엑소뉴클레아제 루프는 Φ29 폴리머라제의 N77-N88과의 상동성 영역 내의 약 12개 내지 약 16개의 아미노산을 포함할 수 있다. 일부 실시양태에서, 치환된 엑소뉴클레아제 루프는 Φ29 폴리머라제의 N77-N88과의 상동성 영역 내의 약 10개 아미노산 내지 20개 이하의 아미노산, 약 5개 아미노산 내지 15개 이하의 아미노산, 약 5개 아미노산 내지 20개 이하의 아미노산, 또는 약 5개 아미노산 내지 25개 이상의 아미노산을 포함한다.
일부 실시양태에서, 본 출원의 변형된 폴리머라제는 Φ29 폴리머라제의 N77-N88과의 상동성의 엑소뉴클레아제 루프를 포함하는 엑소뉴클레아제 도메인의 영역 내의 하나 이상의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 본 개시내용의 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91 중 하나 이상에서의 돌연변이를 포함하는 변형된 Φ29 폴리머라제이다. 일부 실시양태에서, 변형된 폴리머라제는 E75F, R76K, S82C, A83K, D84E, G85A, L86K, P87E, N88R, Y90F, 및 N91S 중 하나 이상을 포함한다. 일부 실시양태에서, 변형된 폴리머라제는 Φ29 폴리머라제 내의 E75, R76, S82, A83, D84, G85, L86, P87, N88, Y90, 및 N91에 상응하는 위치에 하나 이상의 아미노산 돌연변이를 포함한다. 예를 들어, 일부 실시양태에서, 변형된 폴리머라제가 Φ29 폴리머라제 대다수의 서열을 포함하지 않는 경우, 이러한 변형된 폴리머라제는, 예를 들어, 상동성 정렬 또는 관련 기술분야에 공지된 다른 방법에 의해 결정된 바와 같이, 상기 열거된 위치에 상응하는 하나 이상의 아미노산을 포함한다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 TPR1 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 예를 들어, C018은 M2Y 폴리머라제 서열로부터 치환된 TPR1 서브 도메인을 포함하는 키메라 폴리머라제이다. 유사하게, C021은 루실리아 쿠프리나 폴리머라제로부터 치환된 TPR1 서브 도메인을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 팜 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 핑거 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 TPR2 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 일부 실시양태에서, 키메라 폴리머라제 변이체는 상이한 폴리머라제 서열로부터 치환된 섬 서브 도메인을 갖는 대다수의 폴리머라제 서열을 포함한다. 본원에 기재된 바와 같은, 변형된 재조합 폴리머라제는 2개 이상의 도메인 및/또는 서브 도메인 치환을 포함하는 키메라 폴리머라제 변이체를 포함한다.
일부 실시양태에서, 대다수의 서열 내의 2개의 영역 (예를 들어, 도메인/서브 도메인)이 상이한 서열의 2개의 상응하는 영역 (예를 들어, 상응하는 도메인/서브 도메인)으로 치환된다. 예를 들어, 도 4에 도시된 바와 같이, C019는 M2Y 폴리머라제 서열의 상응하는 엑소뉴클레아제 도메인 및 TPR1 서브 도메인으로 치환된 엑소뉴클레아제 도메인 및 TPR1 서브 도메인을 포함하는 키메라 폴리머라제이다. 유사하게, C022는 루실리아 쿠프리나 폴리머라제의 상응하는 엑소뉴클레아제 도메인 및 TPR1 서브 도메인으로 치환된 엑소뉴클레아제 도메인 및 TPR1 서브 도메인을 포함한다. 일부 실시양태에서, 부가의 도메인 및/또는 서브 도메인 치환이 본원에 기재된 변형된 폴리머라제와 함께 고려된다. 예를 들어, 일부 실시양태에서, 대다수의 서열 내의 3개 이상 (예를 들어, 3개, 4개, 5개, 또는 6개)의 영역 (예를 들어, 도메인/서브 도메인)이 상이한 서열의 3개 이상 (예를 들어, 3개, 4개, 5개, 또는 6개)의 상응하는 영역으로 치환된다.
일부 실시양태에서, 키메라 폴리머라제 변이체의 대다수의 폴리머라제 서열은 표 1-3 내의 서열로부터 선택된다. 일부 실시양태에서, 이러한 대다수의 폴리머라제 서열은 표 1-3으로부터 선택된 상이한 폴리머라제 서열로부터 치환된 하나 이상의 영역 및/또는 부분을 포함한다. 예를 들어, 표 4는 표 3으로부터 선택된 키메라 폴리머라제 변이체의 개요를 제공하고, 치환된 영역(들)/부분(들) 및 그 치환이 기초하는 서열에 관한 설명과 함께 각각에 대한 대다수의 폴리머라제 서열을 열거한다.
<표 4>
키메라 폴리머라제 - 치환된 부분
Figure pat00102
Figure pat00103
Figure pat00104
Figure pat00105
그러나, 예를 들어 본원의 표 중 하나 이상에 기재되고 예시된 바와 같은 다른 키메라가 사용될 수 있고/있거나 추가로 변형될 수 있다.
일부 실시양태에서, 키메라 폴리머라제 변이체는 하나 이상의 부위 특이적 돌연변이를 추가로 포함할 수 있다. 따라서, 일부 실시양태에서, 본원에 기재된 하나 이상의 돌연변이 중 임의의 것 (예를 들어, 표 2 내의 각각의 서열에 포함된 하나 이상의 돌연변이 중 임의의 것)이 본 개시내용에 고려된 키메라 폴리머라제 (예를 들어, 상기에 언급되고 표 3에 열거된 바와 같음) 중 임의의 것에 적용될 수 있다. 도 6은 일반적으로, 하나 이상의 돌연변이를 포함하는 키메라 폴리머라제 변이체를 도시한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (602)는 치환된 M2Y 엑소뉴클레아제 도메인 및 이러한 치환된 도메인 이내에서의 돌연변이를 갖는 Φ29 폴리머라제 대다수의 서열을 포함한다. 일부 실시양태에서, 돌연변이체 키메라 폴리머라제는 2개 이상의 상이한 폴리머라제 서열에 상응하는 영역으로 치환된 2개 이상의 영역을 수반한 대다수의 서열을 포함한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (604)는 치환된 엔테로코쿠스 파에시움 폴리머라제 TPR1 서브 도메인 및 치환된 M2Y 폴리머라제 TPR2 서브 도메인을 갖는 Φ29 폴리머라제 대다수의 서열을 포함하며, 폴리머라제 서열 내의 다양한 위치에서 이루어진 부위 특이적 돌연변이를 수반한다. 일부 실시양태에서, 돌연변이체 키메라 폴리머라제는 상이한 폴리머라제에 상응하는 영역으로 치환된 2개 이상의 영역을 수반한 대다수의 서열을 포함한다. 예를 들어, 돌연변이체 키메라 폴리머라제 (606)는 치환된 엔테로코쿠스 파에시움 폴리머라제 TPR1, TPR2, 및 섬 서브 도메인을 갖는 Φ29 폴리머라제 대다수의 서열을 포함하며, 폴리머라제 서열 내의 다양한 위치에서 이루어진 부위 특이적 돌연변이를 수반한다.
표 5는 표 3으로부터 선택된 키메라 폴리머라제 변이체의 개요를 제공하고, 특별한 변이체가 되도록 이루어진 아미노산 돌연변이에 관한 설명과 함께 각각에 대한 대다수의 폴리머라제 서열을 제공한다.
<표 5>
키메라 폴리머라제 - 부위 특이적 돌연변이체
Figure pat00106
그러나, 다른 아미노산 돌연변이가 본원에 기재된 하나 이상의 키메라 폴리머라제 내로 혼입될 수 있다. 예를 들어, 하나 이상의 아미노산 변화가 Φ29 폴리머라제 서열과 관련하여 위치 M8, V51, N62, I71, L107, 및/또는 K131 중 하나 이상, 및/또는 위치 K135, L142, G197, Y224, E239, V250, L253, Y281, I288, T301, R306, R308, D325, D341, K354, T368, E375, A437, A444, E466, D476, A484, E508, D510, K512, E515, K539, D570, 및 T571 중 하나 이상에 혼입될 수 있다. 예를 들어, 일부 실시양태에서, 키메라 폴리머라제는 또한, 하기 아미노산 치환: M8R, V51A, N62D, I71V, L107I, 및/또는 K131E 중 하나 이상, 및/또는 하기 아미노산 치환: K135Q, L142K, G197D, Y224K, E239G, V250A, V250I, L253A, L253H, Y281H, I288L, T301C, R306Q, R308L, D325E, D341E, K354R, T368F, E375Y, A437G, A444T, E466K, D476H, A484E, E508R, D510K, D510R, K512Y, E515Q, K539E, D570S, 및/또는 T571V 중 하나 이상을 포함할 수 있다.
본원에 사용된 바와 같은 용어 "폴리머라제" 및 "중합 효소"는 일반적으로, 중합 반응을 촉매할 수 있는 임의의 효소를 지칭한다. 폴리머라제의 예는 DNA 폴리머라제, RNA 폴리머라제, 열 안정성 폴리머라제, 야생형 폴리머라제, 변형된 폴리머라제, 이. 콜라이 DNA 폴리머라제 I, T7 DNA 폴리머라제, 박테리오파지 T4 DNA 폴리머라제 φ29 (파이29) DNA 폴리머라제, Taq 폴리머라제, Tth 폴리머라제, Tli 폴리머라제, Pfu 폴리머라제, Pwo 폴리머라제, VENT® 폴리머라제, Deep VENT™ 폴리머라제, Ex TAQ™ 폴리머라제, LA TAQ™ 폴리머라제, Sso 폴리머라제, Poc 폴리머라제, Pab 폴리머라제, Mth 폴리머라제, ES4 폴리머라제, Tru 폴리머라제, Tac 폴리머라제, Tne 폴리머라제, Tma 폴리머라제, Tca 폴리머라제, Tih 폴리머라제, Tfi 폴리머라제, PLATINUM® Taq 폴리머라제, Tbr 폴리머라제, Tfl 폴리머라제, Tth 폴리머라제, PFUTURBO® 폴리머라제, PYROBEST™ 폴리머라제, Pwo 폴리머라제, KOD 폴리머라제, Bst 폴리머라제, Sac 폴리머라제, 클레노우 단편, 3'에서 5'로의 엑소뉴클레아제 활성을 지닌 폴리머라제, 및 그의 변이체, 변형된 산물 및 유도체를 포함하나, 이에 제한되지는 않는다. 일부 실시양태에서, 폴리머라제는 단일 서브유닛 폴리머라제이다. 폴리머라제의 부가의 예는 M2Y 폴리머라제, 루실리아 쿠프리나 폴리머라제, 엔테로코쿠스 파에시움 폴리머라제, 바실루스 파지 VMY22 폴리머라제, 바실루스 파지 GA-1 폴리머라제, 악티노마이세스 파지 AV-1 폴리머라제, 칸디다투스 모란박테리아(Moranbacteria) 폴리머라제, 바실루스 파지 MG-B1 폴리머라제, 에게르텔라 종 폴리머라제, 스트렙토코쿠스(Streptococcus) 파지 CP-7 폴리머라제, 박테로이데스 종(Bacteroides sp.) 폴리머라제, 클라미디아 트라코마티스(Chlamydia trachomatis) 폴리머라제, 및 글로보데라 팔리다(Globodera pallida) 폴리머라제를 포함한다. DNA 폴리머라제의 비-제한적 예 및 그의 특성은 특히, 문헌 [DNA Replication 2nd edition, Kornberg and Baker, W. H. Freeman, New York, N.Y. (1991)]에 상세히 기재되어 있다. 이러한 서열의 비-제한적 예는 표 1에서 찾을 수 있다 (서열식별번호: 1-19).
표적 핵산의 핵 염기와 상보적인 dNTP 간의 염기쌍을 형성할 때, 폴리머라제는 새로이 합성된 가닥의 3' 히드록실 말단과 dNTP의 알파 포스페이트 간에 포스포디에스테르 결합을 형성함으로써 dNTP를 새로이 합성된 핵산 가닥 내로 혼입시킨다. 일부 실시양태에서, 폴리머라제는 높은 전진성을 지닌 폴리머라제이다. 그러나, 일부 실시양태에서, 폴리머라제는 감소된 전진성을 지닌 폴리머라제이다. 폴리머라제 전진성은 일반적으로, 핵산 주형을 방출하지 않고서도 dNTP를 핵산 주형 내로 연속적으로 혼입할 수 있는 폴리머라제의 능력을 지칭한다.
일부 실시양태에서, 폴리머라제는 낮은 5'-3' 엑소뉴클레아제 활성 및/또는 3'-5' 엑소뉴클레아제를 수반한 폴리머라제이다. 일부 실시양태에서, 폴리머라제는 상응하는 야생형 폴리머라제와 비교하여 감소된 5'-3' 엑소뉴클레아제 활성 및/또는 3'-5' 활성을 갖는 것으로 변형된다 (예를 들어, 아미노산 치환에 의함). DNA 폴리머라제의 추가의 비-제한적 예는 9°NM™ DNA 폴리머라제 [뉴 잉글랜드 바이오랩스(New England Biolabs)], 및 클레노우 엑소-폴리머라제의 P680G 돌연변이체를 포함한다 (Tuske et al. (2000) JBC 275(31):23759-23768). 일부 실시양태에서, 감소된 전진성을 갖는 폴리머라제는 뉴클레오티드 반복 서열의 하나 이상의 연장물 (예를 들어, 동일한 유형의 2개 이상의 순차적 염기)을 함유하는 주형을 시퀀싱하기 위한 증가된 정확도를 제공한다.
핵산 폴리머라제의 전진성, 엑소뉴클레아제 활성, 상이한 유형의 핵산에 대한 상대적 친화성, 또는 다른 특성은 상응하는 야생형 폴리머라제와 비교하여 돌연변이 또는 다른 변형에 의해 관련 기술분야의 통상의 기술자에 의해 증가되거나 또는 감소될 수 있다.
일부 실시양태에서, 변형된 폴리머라제는 하나 이상의 비-자연 아미노산 치환을 포함한다. 본원에 사용된 바와 같은, "비-자연 아미노산"은 하기 20개의 유전적으로 코딩된 알파-아미노산 이외의 임의의 아미노산, 변형된 아미노산, 또는 아미노산 유사체를 지칭한다: 알라닌, 아르기닌, 아스파라긴, 아스파르트산, 시스테인, 글루타민, 글루탐산, 글리신, 히스티딘, 이소류신, 류신, 리신, 메티오닌, 페닐알라닌, 프롤린, 세린, 트레오닌, 트립토판, 티로신, 발린. 일부 실시양태에서, 비-자연 아미노산은 상기 20개의 알파-아미노산 이외의 자연 발생 화합물을 포함할 수 있다. 비-자연 아미노산 및 비-자연 아미노산을 단백질 서열 내로 혼입하는 방법은, 예를 들어, 미국 특허 번호 7,045,337 (그의 내용이 본원에 참조로 포함된다)에 기재된 바와 같이, 관련 기술분야에 공지되어 있다.
본원에 기재된 바와 같은, 폴리머라제 및/또는 폴리머라제 서열은 이들이 공통 조상의 단백질 또는 단백질 서열로부터 자연적으로 또는 인공적으로 유래될 때 "상동"이다. 유사하게, 핵산 및/또는 핵산 서열은 이들이 공통 조상의 핵산 또는 핵산 서열로부터 자연적으로 또는 인공적으로 유래될 때 상동이다. 예를 들어, 임의의 자연 발생 핵산은 폴리펩티드 내의 소정의 위치에서 자연 발생하지 않는 아미노산을 코딩하는 적어도 하나의 특이적 코돈을 포함하도록 임의의 이용 가능한 돌연변이 유발 방법에 의해 변형될 수 있다. 발현될 때, 이와 같이 돌연변이 유발된 핵산은 하나 이상의 돌연변이된 아미노산을 포함하는 폴리펩티드를 코딩한다. 일부 실시양태에서, 상동성은 일반적으로, 2개 이상의 핵산 또는 단백질 (또는 그의 서열) 간의 서열 유사성으로부터 추론된다. 상동성 확립에 유용한 서열 간의 유사성의 정확한 백분율은 문제가 되는 핵산 및 단백질에 따라 다양하지만, 25% 정도의 서열 유사성이 상동성을 확립하는 데 일상적으로 사용된다. 더 높은 수준의 서열 유사성, 예를 들어, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% 또는 99% 또는 그 초과가 또한, 상동성을 확립하는 데 사용될 수 있다. 서열 유사성 백분율을 결정하는 방법은 관련 기술분야에 널리 공지되어 있다. 일부 실시양태에서, 유사성은, 예를 들어, 디폴트 파라미터를 사용하여, 예를 들어 BLASTP 및 BLASTN 알고리즘을 포함한, 상기 기재된 것과 같은 알고리즘을 사용하여 결정될 수 있다.
일부 실시양태에서, 본 개시내용의 폴리머라제를 발현하기 위해, 이러한 폴리머라제를 코딩하는 DNA를 하나 이상의 발현 벡터 내로 삽입하여, 이와 같이 코딩된 폴리머라제가 전사 및 번역 제어 서열과 작동적으로 연결되도록 한다 [예를 들어, 미국 특허 번호 6,914,128 (그의 내용이 본원에 참조로 포함된다) 참조]. 이와 관련하여, 용어 "작동적으로 연결된"이란 폴리머라제를 코딩하는 서열이 벡터 내로 라이게이션되어 이러한 벡터 내에서의 전사 및 번역 제어 서열이 폴리머라제의 전사 및 번역을 조절하는 의도된 기능을 수행하도록 하는 것을 의미한다. 발현 벡터 및 발현 제어 서열은 사용된 발현 숙주 세포와 화합성이 되도록 선택된다. 폴리머라제-코딩 서열이 표준 방법 (예를 들어, 폴리머라제-코딩 서열 및 벡터 상의 상보적 제한 부위의 라이게이션, 및 제한 부위가 존재하지 않는 경우 평활 말단 라이게이션)에 의해 발현 벡터 내로 삽입된다.
변형된 폴리머라제의 발현을 위하여, 변형된 폴리머라제를 코딩하는 발현 벡터를 표준 기술에 의해 숙주 세포 내로 형질감염시킬 수 있다. 용어 "형질감염"의 다양한 형태는 외인성 DNA를 원핵 또는 진핵 숙주 세포 내로 도입하는 데 흔히 사용되는 광범위한 기술, 예를 들어, 전기천공, 인산칼슘 침전, DEAE-덱스트란 형질감염 등을 포괄하는 것으로 의도된다. 본 개시내용의 폴리머라제를 발현하는 데 적합한 숙주 세포는 원핵 생물, 효모, 또는 고등 진핵 세포를 포함한다.
이러한 목적에 적합한 원핵 생물은 유박테리아, 예컨대 그램 음성 또는 그램 양성 유기체, 예를 들어, 엔테로박테리아세아에(Enterobacteriaceae), 예컨대 에스케리키아(Escherichia), 예를 들어, 이. 콜라이, 엔테로박터(Enterobacter), 에르위니아(Erwinia), 클렙시엘라(Klebsiella), 프로테우스(Proteus), 살모넬라(Salmonella), 예를 들어, 살모넬라 티피무륨(Salmonella typhimurium), 세라티아(Serratia), 예를 들어, 세라티아 마르세스칸스(Serratia marcescans), 및 시겔라(Shigella) 뿐만 아니라 바실루스, 예컨대 비. 서브틸리스(B. subtilis) 및 비. 리케니포르미스(B. licheniformis), 슈도모나스(Pseudomonas), 예컨대 피. 아에루기노사(P. aeruginosa), 및 스트렙토마이세스(Streptomyces)를 포함한다. 원핵 생물 이외에도, 진핵 미생물, 예컨대 섬유상 진균 또는 효모가 폴리펩티드 코딩 벡터에 적합한 클로닝 또는 발현 숙주이다. 사카로마이세스 세레비시아에(Saccharomyces cerevisiae), 또는 일반 빵 효모가 하등 진핵 숙주 미생물 중에서 가장 흔히 사용되고 있다. 그러나, 수많은 다른 속, 종, 및 균주, 예컨대 시조사카로마이세스 폼베(Schizosaccharomyces pombe); 클루이베로마이세스(Kluyveromyces) 숙주, 예컨대, 예를 들어, 케이. 락티스(K. lactis), 케이. 프라길리스(K. fragilis), 케이. 불가리쿠스(K. bulgaricus), 케이. 위케라미이(K. wickeramii), 케이. 왈티이(K. waltii), 케이. 드로소필라룸(K. drosophilarum), 케이. 써모톨레란스(K. thermotolerans), 및 케이. 마륵시아누스(K. marxianus); 피치아 파스토리스(Pichia pastoris); 칸디다(Candida); 트리코데르마 레에시아(Trichoderma reesia); 뉴로스포라 크라사(Neurospora crassa); 쉬반니오마이세스(Schwanniomyces), 예컨대 쉬반니오마이세스 옥시덴탈리스(Schwanniomyces occidentalis); 및 섬유상 진균, 예컨대, 예를 들어, 뉴로스포라(Neurospora), 페니실륨(Penicillium), 톨리포클라디움(Tolypocladium), 및 아스페르길루스(Aspergillus) 숙주, 예컨대 에이. 니둘란스(A. nidulans) 및 에이. 니제르(A. niger)가 통상적으로 이용 가능하고 본원에 유용하다.
일부 실시양태에서, 숙주 세포는 폴리머라제 생산을 위하여 상기 언급된 발현 또는 클로닝 벡터로 형질전환시키고, 프로모터를 유도하거나, 형질전환체를 선택하거나 또는 원하는 서열을 코딩하는 유전자를 증폭시키기 위해 적절하게 변형시킨 통상적인 영양 배지에서 배양한다. 폴리머라제를 생산하기 위해 사용되는 숙주 세포는 각종 배지에서 배양될 수 있다. 상업적으로 이용 가능한 배지, 예컨대 햄스(Ham's) F10™ [시그마(Sigma)], 최소 필수 배지™ (MEM) (시그마), RPMI-1640 (시그마), 및 둘벡코 변형된 이글 배지™ (DMEM) (시그마)가 숙주 세포를 배양하는 데 적합하다. 배양 조건, 예컨대 온도, pH 등은 발현을 위해 선택된 숙주 세포를 이용하여 앞서 사용된 것이고, 관련 기술분야의 통상의 기술자에게 명백할 것이다.
일부 실시양태에서, 폴리머라제 변이체는 세포 내에서, 세포질 주위 공간에서 생산되거나 또는 세포의 배지로 직접 분비될 수 있다. 폴리머라제 변이체가 세포 내에서 생산되는 실시양태에서, 숙주 세포 또는 용해된 세포 (예를 들어, 균질화로부터 생성됨)의 미립자 부스러기는 원심 분리 또는 한외 여과를 포함하지만 이에 제한되지는 않는 다양한 수단에 의해 제거될 수 있다. 폴리머라제가 배지 내로 분비되는 경우, 이러한 발현 시스템으로부터의 상등액은 상업적으로 이용 가능한 단백질 농축 필터를 사용하여 먼저 농축될 수 있으며, 그 후 하나 이상의 부가의 정제 기술을 수행할 수 있으며, 이는 단백질 친화성 크로마토그래피를 포함한 친화성 크로마토그래피, 이온 교환 크로마토그래피, 예컨대 음이온 또는 양이온 교환 크로마토그래피, 및 소수성 상호 작용 크로마토그래피를 포함하지만, 이에 제한되지는 않는다.
일부 실시양태에서, 본 출원의 측면은 생물학적 샘플의 검정과 관계된 방법에 사용될 수 있다. 예시적인 실시양태에서, 본원에 제공된 방법은 샘플 내의 하나 이상의 핵산 또는 폴리펩티드의 서열을 결정하고/하거나 샘플 내의 하나 이상의 핵산 또는 폴리펩티드 변이체 (예를 들어, 관심 유전자 내의 하나 이상의 돌연변이)의 존재 또는 부재를 결정하기 위해 사용되는 기술에 유용하다. 일부 실시양태에서, 시험은 핵산 서열 정보를 제공하거나 또는 진단, 예후, 및/또는 치료 목적으로 하나 이상의 관심 핵산의 존재 또는 부재를 결정하기 위해 환자 샘플 (예를 들어, 인간 환자 샘플) 상에서 수행될 수 있다. 일부 예에서, 진단 시험은, 예를 들어 대상체의 생물학적 샘플 내의 무세포 DNA 분자 및/또는 발현 산물 (예를 들어, RNA)을 시퀀싱함으로써, 대상체의 생물학적 샘플 내의 핵산 분자를 시퀀싱하는 것을 포함할 수 있다. 예를 들어, 본 개시내용은 공동 계류중인 미국 특허 출원 번호: 14/543,865, 14/543,867, 14/543,888, 14/821,656, 14/821,686, 14/821,688, 15/161,067, 15/161,088, 15/161,125, 15/255,245, 15/255,303, 15/255,624, 15/261,697, 15/261,724, 62/289,019, 62/296,546, 62/310,398, 62/339,790, 62/343,997, 62/344,123, 및 62/426,144 (각각의 내용이 본원에 참조로 포함된다)에 기재된 기술에 유리하게 활용될 수 있는 방법 및 조성물을 제공한다.
본 출원의 일부 측면은 생물학적 중합체, 예컨대 핵산 및 단백질을 시퀀싱할 수 있는 기술에 유용하다. 일부 실시양태에서, 본 출원에 기재된 방법 및 조성물은 (예를 들어, 일련의 표지된 뉴클레오티드 또는 아미노산 단량체의 시간 과정에 따른 혼입을 검출함으로써) 핵산 또는 단백질 내로 혼입되는 일련의 뉴클레오티드 또는 아미노산 단량체를 확인해 주는 기술에 사용될 수 있다. 일부 실시양태에서, 본 출원에 기재된 방법 및 조성물은 중합 효소에 의해 합성된 주형 의존성 핵산 시퀀싱 반응 산물 내로 혼입되는 일련의 뉴클레오티드를 확인해 주는 기술 내로 혼입될 수 있다.
시퀀싱 동안, 중합 효소는 표적 핵산 분자 (예를 들어, 시퀀싱 주형의 핵산 분자)의 프라이밍 위치에 커플링 (예를 들어, 부착)될 수 있다. 프라이밍 위치는 표적 핵산 분자의 부분에 상보적인 프라이머를 포함할 수 있다. 대안으로서 프라이밍 위치는 표적 핵산 분자의 이중 가닥 절편 내에 제공되는 갭 또는 닉(nick)이다. 갭 또는 닉은 0 내지 적어도 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 20, 30, 또는 40개의 뉴클레오티드 길이일 수 있다. 닉은 이중 가닥 서열의 한 가닥에서 브레이크를 제공할 수 있으며, 이는 중합 효소, 예컨대, 예를 들어 가닥 치환 폴리머라제 효소를 위한 프라이밍 위치를 제공할 수 있다.
일부 경우에, 시퀀싱 프라이머는 고체 지지체에 고정화될 수 있거나 또는 고정화되지 않을 수 있는 표적 핵산 분자에 어닐링될 수 있다. 고체 지지체는, 예를 들어, 핵산 시퀀싱에 사용되는 통합 장치 상의 샘플 웰을 포함할 수 있다. 일부 실시양태에서, 시퀀싱 프라이머는 고체 지지체에 고정화될 수 있고, 표적 핵산 분자의 혼성화는 또한, 표적 핵산 분자를 고체 지지체에 고정화시킨다. 일부 실시양태에서, 폴리머라제는 고체 지지체에 고정화되고 가용성 프라이머 및 표적 핵산은 폴리머라제에 접촉된다. 그러나, 일부 실시양태에서, 폴리머라제, 표적 핵산 및 프라이머를 포함하는 복합체가 용액 중에 형성되고, 이러한 복합체는 (예를 들어, 폴리머라제, 프라이머, 및/또는 표적 핵산의 고정화를 통해) 고체 지지체에 고정화된다. 일부 실시양태에서, 샘플 웰 내의 어떠한 성분도 고체 지지체에 고정화되지 않는다. 예를 들어, 일부 실시양태에서, 폴리머라제, 표적 핵산, 및 프라이머를 포함하는 복합체가 용액 중에 형성되고, 이러한 복합체는 고체 지지체에 고정화되지 않는다.
적절한 조건 하에, 어닐링된 프라이머/표적 핵산에 접촉되는 폴리머라제 효소는 하나 이상의 뉴클레오티드를 프라이머 상에 부가하거나 혼입시킬 수 있으며, 뉴클레오티드는 프라이머에 5'에서 3'로의 주형 의존성 방식으로 부가될 수 있다. 이와 같이 뉴클레오티드를 (예를 들어, 폴리머라제의 작용을 통해) 프라이머 상으로 혼입하는 것은 일반적으로, 프라이머 연장 반응으로서 지칭될 수 있다. 각각의 뉴클레오티드는 핵산 연장 반응 동안 검출 및 확인될 수 있고 (예를 들어, 그의 발광 수명 및/또는 다른 특징에 기초한다), 연장된 프라이머 내로 혼입된 각각의 뉴클레오티드를 결정하고, 이에 따라 새로이 합성된 핵산 분자의 서열을 결정하는데 사용될 수 있는 검출 가능한 태그와 연합될 수 있다. 새로이 합성된 핵산 분자의 서열 상보성을 통해, 표적 핵산 분자의 서열을 결정할 수도 있다. 일부 경우에, 시퀀싱 프라이머를 표적 핵산 분자에 어닐링시키고 뉴클레오타이드를 시퀀싱 프라이머에 혼입시키는 것은 유사한 반응 조건 (예를 들어, 동일하거나 또는 유사한 반응 온도) 또는 상이한 반응 조건 (예를 들어, 상이한 반응 온도)에서 발생할 수 있다. 일부 실시양태에서, 합성 방법에 의한 시퀀싱은 표적 핵산 분자의 집단 (예를 들어, 표적 핵산의 카피)의 존재 및/또는 표적 핵산의 집단을 달성하기 위한 표적 핵산의 증폭 단계를 포함할 수 있다. 그러나, 일부 실시양태에서, 합성에 의한 시퀀싱은 평가되는 각각의 반응에서 단일 분자의 서열을 결정하는데 사용된다 (그리고 핵산 증폭은 시퀀싱을 위한 표적 주형을 제조하는데 필요하지 않다). 일부 실시양태에서, 복수 개의 단일 분자 시퀀싱 반응은 본 출원의 측면에 따라서 병렬식으로 (예를 들어, 단일 통합 장치 상에서) 수행된다. 예를 들어, 일부 실시양태에서, 복수 개의 단일 분자 시퀀싱 반응은 통합 장치 상의 별도의 반응 챔버에서 각각 수행된다.
일부 실시양태에서, 본 개시내용의 중합 효소는 상당히 작은 용적의 샘플 웰에서 시행되는 단일 분자 시퀀싱 반응에 유용하다. 예를 들어, 샘플 웰의 용적은 일부 구현에서 약 10-21 리터 내지 약 10-15 리터일 수 있다. 샘플 웰이 작은 용적을 갖기 때문에, 단일 샘플 이벤트 (예를 들어, 단일 분자 이벤트)의 검출이 달성 가능하다. 일부 실시양태에서, 표면 (예를 들어, 샘플 웰의 표면)은 본원에 기재된 폴리머라제를 수용하도록 설정된다. 일부 실시양태에서, 샘플 웰은 바닥면과 같은 샘플 웰의 표면 상에 배치될 수 있는 폴리머라제를 수용한다. 일부 실시양태에서, 샘플 웰은 통합 장치 내에 형성되며, 여기서 샘플 웰의 바닥면은 그것이 형성되는 통합 장치의 표면에 대해 원위이다.
특정 실시양태에서, 본원에 기재된 기술은 샘플 웰에 부가될 수 있는 중합 효소, 및 그의 복합체에 관한 것이다. 일부 실시양태에서, 본원에 기재된 중합 효소는 샘플 웰의 표적 용적 (예를 들어, 반응 용적)에 한정될 수 있다. 일부 실시양태에서, 표적 용적은 샘플 웰 내의 영역이다. 하나 이상의 중합 효소가 바닥면 위에 고정화되어야 하는 실시양태에서, 하나 이상의 중합 효소 (예를 들어, 중합 효소 및 그의 복합체)의 부착을 허용하도록 바닥면을 기능화하는 것이 바람직할 수 있다. 일부 실시양태에서, 바닥면은 커플링 기를 포함하는 물질로 기능화된다. 예를 들어, 커플링 기는 화학적 모이어티, 예컨대 아민 기, 카르복실 기, 히드록실 기, 술프히드릴 기, 금속, 킬레이트제 등을 포함할 수 있다. 또 다른 한편으로, 이들은 특이적 결합 요소, 예컨대 비오틴, 아비딘, 스트렙타비딘, 뉴트라비딘, 렉틴, SNAP-태그™ 또는 그에 대한 기질, 연합 또는 결합 펩티드 또는 단백질, 항체 또는 항체 단편, 핵산 또는 핵산 유사체 등을 포함할 수 있다. 부가적으로, 또는 또 다른 한편으로, 커플링 기는 일부 경우에 화학적 작용기와 특이적 결합 요소 둘 다를 포함할 수 있는 관심 분자 (예를 들어, 중합 효소 또는 그의 복합체)와 커플링 또는 결합하는데 사용되는 부가의 기와 커플링하기 위해 사용될 수 있다. 한 예로서, 커플링 기, 예를 들어, 비오틴은 기질 표면 상에 증착될 수 있고 소정의 영역에서 선택적으로 활성화될 수 있다. 이어서, 중간 결합제, 예를 들어, 스트렙타비딘이 제1 커플링 기와 커플링될 수 있다. 이러한 특별한 예에서 비오티닐화될 것인 관심 분자 (예를 들어, 중합 효소 또는 그의 복합체)는 스트렙타비딘과 커플링된다. 일부 실시양태에서, 본원에 기재된 중합 효소는 폴리머라제를 표면 (예를 들어, 샘플 웰의 표면)에 고정화시키는 커플링 기와의 상호 작용을 형성할 수 있는 커플링 모이어티를 추가로 포함할 수 있다. 예를 들어, 일부 실시양태에서, 중합 효소는 아비딘 단백질과 결합할 수 있는 N-말단 또는 C-말단 비오티닐화 서열을 포함한다. 일부 실시양태에서, 비오티닐화 서열은 링커 서열을 추가로 포함한다. 예를 들어, 일부 실시양태에서, C-말단 링커/비오티닐화 서열은 아미노산 서열 GGGSGGGSGGGSGLNDFFEAQKIEWHE (서열식별번호: 517)을 포함한다.
실시예
실시예 1. 변형된 폴리머라제의 발현 및 평가
재조합 폴리머라제 변이체는 이. 콜라이에서 발현되었고, 이를 His-스핀 컬럼을 사용하여 150 mL 규모의 배양물로부터 정제하였다. 단백질 순도는 SDS-PAGE에 이어 쿠마시 블루(Coomassie Blue) 염색함으로써 분석되었다 (도 7). 완충액 교환 및 단백질 농축 후, 30℃에서 30분 동안 트랩 체이스(trap chase)를 이용하여 dNTP의 존재하에 재조합 변이체를 활성 및 전진성에 관하여 평가하였다. 키메라 폴리머라제 변이체 C017 및 C020은 트랩의 존재하에 활성, 전진성, 및 합성 길이를 나타내었다. 변이체 폴리머라제에 의한 dNTP 유사체의 활용률을 측정하여 시퀀싱 반응에서의 폴리머라제의 적합성을 평가하였다. 상동 돌연변이체 변이체와 키메라 폴리머라제 변이체 둘 다는 dN6P의 활용률을 표시하였다. 단일 분자 시퀀싱으로부터의 결과가 하기 표 6에 제시된다.
<표 6>
변형된 폴리머라제를 이용한 시퀀싱 결과
Figure pat00107
등가물 및 범위
몇 가지 발명적 실시양태가 본원에 기재되고 예시되었지만, 관련 기술분야의 통상의 기술자는 기능을 수행하고/하거나 그 결과 및/또는 본원에 기재된 이점 중 하나 이상을 수득하기 위한 각종 다른 수단 및/또는 구조를 용이하게 구상할 것이며, 이러한 변이 및/또는 변형 각각은 본원에 기재된 발명적 실시양태의 범위 내에 있는 것으로 간주된다. 보다 일반적으로, 관련 기술분야의 통상의 기술자는 본원에 기재된 모든 파라미터, 치수, 물질, 및 입체 배치가 예시적인 것으로 의도되고 실제 파라미터, 치수, 물질, 및/또는 입체 배치가, 본 발명의 교시가 사용하는 특이적 적용(들)에 의존한다는 것을 용이하게 인지할 것이다. 관련 기술분야의 통상의 기술자는 단지 일상적인 실험을 사용하여, 본원에 기재된 특이적 발명적 실시양태에 대한 많은 등가물을 인식하거나 또는 확인할 수 있을 것이다. 따라서, 전술한 실시양태는 단지 한 예로서 제시되고, 첨부된 청구범위 및 그에 대한 등가물의 범위 내에서, 발명적 실시양태는 구체적으로 기재되고 청구된 것과 다르게 실시될 수 있다는 것을 이해해야 한다. 본 개시내용의 발명적 실시양태는 본원에 기재된 각각의 개별적인 특색, 시스템, 물품, 물질, 키트 및/또는 방법에 관한 것이다. 또한, 이러한 특색, 시스템, 물품, 물질, 키트 및/또는 방법이 서로 불일치하지 않는 경우, 이러한 특색, 시스템, 물품, 물질, 키트 및/또는 방법 중 2개 이상의 임의의 조합이 본 개시내용의 발명적 범위 내에 포함된다.
본원에 정의되고 사용된 바와 같은 모든 정의가, 사전적 정의, 참조로 포함된 문헌에서의 정의, 및/또는 정의된 용어의 통상적인 의미에 비해 우선하는 것으로 이해되어야 한다.
본원에 개시된 모든 참고 문헌, 특허 및 특허 출원은 각각이 인용되는 주제에 관해서 참조로 포함되며, 일부 경우에는 그 문서의 전체를 포괄할 수 있다.
본 명세서 및 청구범위에 사용된 바와 같은 단수 형태는 달리 명백하게 표시되지 않는 한, "적어도 하나"를 의미하는 것으로 이해되어야 한다.
본 명세서 및 청구범위에 사용된 바와 같은 문구 "및/또는"은, 이와 같이 결합된 요소 중 "어느 하나 또는 양쪽", 즉 일부 경우에는 결합적으로 존재하고 다른 경우에는 분리적으로 존재하는 요소를 의미하는 것으로 이해되어야 한다. "및/또는"으로 열거된 다수의 요소는 동일한 방식으로, 즉 결합된 요소 중 "하나 이상"으로 해석되어야 한다. 구체적으로 확인된 요소와 관련이 있거나 관련이 없든지 간에, "및/또는" 구절에 의해 구체적으로 확인된 요소 이외에 다른 요소가 임의로 존재할 수 있다. 따라서, 비-제한적 예로서, "포함하는" 것과 같이 제한을 두지 않은 언어와 연계해서 사용될 때, "A 및/또는 B"에 대한 언급은 한 실시양태에서 A 만을 지칭할 수 있고 (B 이외의 요소를 임의로 포함함); 또 다른 실시 양태에서, B 만을 지칭할 수 있으며 (A 이외의 요소를 임의로 포함함); 또한 또 다른 실시양태에서, A와 B 둘 다를 지칭할 수 있다 (다른 요소를 임의로 포함함).
본 명세서 및 청구범위에 사용된 바와 같은 "또는"은 상기 정의된 바와 같은 "및/또는"과 동일한 의미를 갖는 것으로 이해되어야 한다. 예를 들어, 목록에서 항목을 분리할 때, "또는" 또는 "및/또는"은 포괄적인 것으로 해석되어야 하는데, 즉 수많은 요소 또는 요소 목록, 및 임의로 부가의 목록에 없는 항목 중 적어도 하나뿐만 아니라 2개 이상을 포함한다. 그 반대로 명백하게 표시된 용어, 예컨대 "오직 하나" 또는 "정확히 하나", 또는 청구범위에서 사용되는 경우 "~로 이루어진"이란 용어만이 수많은 요소 또는 요소 목록 중 정확히 하나의 요소를 포함하는 것을 지칭할 것이다. 일반적으로, 본원에 사용된 바와 같은 용어 "또는"은 "어느 하나", "하나", "오직 하나" 또는 "정확히 하나"와 같이 배타적인 용어가 선행될 때, 배타적인 대안 (즉, "하나 또는 다른 것이지만, 둘 다가 아닌")을 표시하는 것으로 해석되어야 한다. 청구범위에서 사용될 때 "본질적으로 이루어지는"은 특허법 분야에서 사용된 바와 같은 그의 통상적인 의미를 지닐 것이다.
본 명세서 및 청구범위에 사용된 바와 같이, 하나 이상의 요소의 목록과 관련하여 "적어도 하나"라는 문구는 상기 요소의 목록 내의 임의의 하나 이상의 요소로부터 선택된 적어도 하나의 요소를 의미하는 것으로 이해되어야 하지만, 요소의 목록 내에 구체적으로 열거된 각각의 및 모든 요소 중 적어로 하나를 반드시 포함하지 않고, 요소의 목록 내의 요소의 임의의 조합을 배제하지 않는다. 이러한 정의는 또한, 구체적으로 확인된 요소와 관련이 있는지의 여부와 상관없이, "적어도 하나"라는 문구가 지칭된 요소 목록 내에서 구체적으로 확인된 요소 이외에 요소가 임의로 존재할 수 있게 해준다. 따라서, 비-제한적 예로서, "A와 B 중 적어도 하나" (또는 동등하게, "A 또는 B 중 적어도 하나" 또는 동등하게는 "A 및/또는 B 중 적어도 하나")는 한 실시양태에서, 적어도 하나, 임의로 2개 이상의 A를 포함하고, B가 존재하지 않은 것 (및 임의로 B 이외의 요소를 포함함)을 지칭할 수 있고; 또 다른 실시 양태에서, 적어도 하나, 임의로 2개 이상의 B를 포함하고, A가 존재하지 않은 것 (및 임의로 A 이외의 요소를 포함함)을 지칭할 수 있으며; 또한 또 다른 실시양태에서, 적어도 하나, 임의로 2개 이상의 A를 포함하고, 적어도 하나, 임의로 2개 이상의 B를 포함하는 것 (및 임의로 다른 원소를 포함함)을 지칭할 수 있다.
반대로 명확하게 표시되지 않는 한, 둘 이상의 단계 또는 동작을 포함하는 본원에 청구된 임의의 방법에서는, 그러한 방법의 단계 또는 동작의 순서가 반드시, 그 방법의 단계 또는 동작이 나열되는 순서로 제한되지 않는다는 것을 이해해야 한다.
청구범위뿐만 아니라 상기 명세서에서, "포함하는", "포함하는", "수반하는", "갖는", "함유하는", "포함하는", "보유하다", "구성된" 등과 같은 모든 이행 어구는 제한을 두지 않는 것으로, 즉 포함하나 이에 제한되지는 않는 것을 의미하는 것으로 이해되어야 한다. 이행 어구 "~로 이루어지는" 및 "본질적으로 ~로 이루어지는" 것 만이 미국 특허청 특허 심사 절차 매뉴얼, 섹션 2111.03에 명시된 바와 같이, 각각 폐쇄 또는 반-폐쇄 이행 어구일 것이다. 제한을 두지 않은 이행 어구 (예를 들어, "포함하는")를 사용하여 본 명세서에 기재된 실시양태는 또한, 대안 실시양태에서 제한을 두지 않은 이행 어구에 의해 기재된 특색으로 "이루어진" 및 "본질적으로 이루어진" 것으로 고려된다. 예를 들어, 본 개시내용이 "A 및 B를 포함하는 조성물"을 기재하는 경우, 본 개시내용은 또한, 대안 실시양태에서 "A 및 B로 이루어진 조성물" 및 "본질적으로 A 및 B로 이루어진 조성물"을 고려한다.
SEQUENCE LISTING <110> Quantum-Si Incorporated <120> POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS <130> R0708.70022WO00 <140> Not Yet Assigned <141> Concurrently Herewith <150> US 62/436,410 <151> 2016-12-19 <160> 539 <170> PatentIn version 3.5 <210> 1 <211> 575 <212> PRT <213> Bacillus phage phi29 <400> 1 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 2 <211> 572 <212> PRT <213> Bacteriophage M2Y <400> 2 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 3 <211> 830 <212> PRT <213> Lucilia cuprina <400> 3 Met Ala Arg Lys Arg Pro Ile Arg Ile Thr Lys Asn Asp Arg Ala Glu 1 5 10 15 Tyr Lys Arg Leu Ser Lys Asn Ala Lys Ser Lys Leu Asn Arg Thr Val 20 25 30 Lys Asn Tyr Gly Ile Asp Leu Ser Asn Asp Val Asp Ile Pro Lys Leu 35 40 45 Ser Asp Phe Lys Thr Arg Lys Glu Phe Asn Asp Trp Lys Gln Lys Ile 50 55 60 Thr Ser Phe Thr Ser Arg Ser Asn Gln Glu Tyr Gln Phe Arg Lys Asn 65 70 75 80 Glu Tyr Gly Val Val Ala Ser Val Lys Glu Leu Asn Glu Ile Lys Arg 85 90 95 Asn Thr Lys Lys Ala Gln Lys Ile Ala Lys Glu Lys Ile Asp Lys Ala 100 105 110 Met Lys Leu Asp Phe Tyr Val Glu Gly Glu Arg Gln Gly Lys Val Lys 115 120 125 Asp Arg Ile Lys Leu Met Lys Lys Glu Glu Val Ala Gly Val Ser Val 130 135 140 Pro Val Asp Phe Asp Phe Asp Lys Ile Gln Thr Arg Lys Arg Leu Glu 145 150 155 160 Asp Lys Ala Gly Phe Met Glu Glu Arg Ala Thr Gly Asp Tyr Tyr Arg 165 170 175 Lys Lys Asp Ile Gln Met Lys Glu Asn Phe Ile Ser Met Ile Glu Gln 180 185 190 Gly Phe Asn Ser Asp Ala Asp Glu Val Ile Lys Lys Leu Lys Lys Ile 195 200 205 Pro Pro Asp Asp Phe Val Glu Leu Thr Ile Val Thr Asp Glu Ile Asp 210 215 220 Phe Arg Asn Tyr Gly Ser Lys Asn Glu Gly Gly Ile Asn Asp Glu Asp 225 230 235 240 Lys Leu Glu Glu Leu Asn Asn Thr Leu Asn Asp Tyr Phe Asn Glu Thr 245 250 255 Thr Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu 260 265 270 Ile Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe 275 280 285 Met Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asn Leu 290 295 300 Lys Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr 305 310 315 320 Thr Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile 325 330 335 Ser Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp 340 345 350 Gly Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu 355 360 365 Pro Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu 370 375 380 Lys Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile 385 390 395 400 Asp Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala 405 410 415 Glu Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn 420 425 430 Gly Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr 435 440 445 Glu Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg 450 455 460 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Thr 465 470 475 480 Lys Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Val Asn Ser Leu Tyr 485 490 495 Pro Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro 500 505 510 Phe Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln 515 520 525 Lys Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile 530 535 540 Gln Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser 545 550 555 560 Ser Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp 565 570 575 Glu Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys 580 585 590 Gly Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp 595 600 605 Lys Trp Met Leu Val Lys Asn Met Ser Ala Gly Ala Lys Lys Ala Ile 610 615 620 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro 625 630 635 640 Asp Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly 645 650 655 Phe Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val 660 665 670 Gly Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala 675 680 685 Gln Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His 690 695 700 Leu Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp 705 710 715 720 Asp Val Leu Gly Tyr Trp Lys Lys Glu Gly Gln Phe Lys Gln Gly Lys 725 730 735 Phe Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val 740 745 750 Arg Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Ile Lys 755 760 765 Thr Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys 770 775 780 Cys Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn 785 790 795 800 Phe Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val 805 810 815 Tyr Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 820 825 830 <210> 4 <211> 589 <212> PRT <213> Lucilia cuprina (mod.) <400> 4 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 20 25 30 Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 35 40 45 Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 65 70 75 80 Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 85 90 95 Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 100 105 110 Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 145 150 155 160 Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 180 185 190 Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr Glu 195 200 205 Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Thr Lys 225 230 235 240 Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Val Asn Ser Leu Tyr Pro 245 250 255 Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 260 265 270 Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 275 280 285 Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 290 295 300 Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 305 310 315 320 Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 325 330 335 Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 340 345 350 Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp Lys 355 360 365 Trp Met Leu Val Lys Asn Met Ser Ala Gly Ala Lys Lys Ala Ile Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe 405 410 415 Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly 420 425 430 Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln 435 440 445 Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu 450 455 460 Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp Asp 465 470 475 480 Val Leu Gly Tyr Trp Lys Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe 485 490 495 Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg 500 505 510 Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Ile Lys Thr 515 520 525 Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys 530 535 540 Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe 545 550 555 560 Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr 565 570 575 Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 580 585 <210> 5 <211> 573 <212> PRT <213> Enterococcus faecium <400> 5 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 6 <211> 592 <212> PRT <213> Bacillus phage VMY22 <400> 6 Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr 1 5 10 15 Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp 20 25 30 Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp 35 40 45 Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His 50 55 60 Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys 65 70 75 80 Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val 85 90 95 Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly 100 105 110 Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp 130 135 140 Ile Asp Tyr Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu 145 150 155 160 Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu 165 170 175 Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala 180 185 190 Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val 195 200 205 Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met 210 215 220 Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn 225 230 235 240 Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Val 245 250 255 Asn Ser Leu Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly 260 265 270 Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro 275 280 285 Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His 290 295 300 Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu 305 310 315 320 Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn 325 330 335 Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu 340 345 350 Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn 355 360 365 Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro 370 375 380 Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys 385 390 395 400 Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp 405 410 415 Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro 420 425 430 Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met 435 440 445 Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp 450 455 460 Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys 465 470 475 480 Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Ala Phe Glu Cys Met 485 490 495 Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met 500 505 510 Tyr Ala Lys Phe Met Ser Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Met 515 520 525 Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val 530 535 540 Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg 545 550 555 560 Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys 565 570 575 His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys 580 585 590 <210> 7 <211> 578 <212> PRT <213> Bacillus phage GA-1 <400> 7 Met Ala Arg Ser Val Tyr Val Cys Asp Phe Glu Thr Thr Thr Asp Pro 1 5 10 15 Glu Asp Cys Arg Leu Trp Ala Trp Gly Trp Met Asp Ile Tyr Asn Thr 20 25 30 Asp Lys Trp Ser Tyr Gly Glu Asp Ile Asp Ser Phe Met Glu Trp Ala 35 40 45 Leu Asn Ser Asn Ser Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ser Phe Ile Leu Pro Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu 65 70 75 80 Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly 85 90 95 Met Gly Gln Trp Tyr Ala Val Asp Val Cys Ile Asn Thr Arg Gly Lys 100 105 110 Asn Lys Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Lys Val Glu Gln Ile Ala Lys Gly Phe Gly Leu Pro Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr Lys Lys Tyr Arg Pro Val Gly Tyr Val Met Asp Asp 145 150 155 160 Asn Glu Ile Glu Tyr Leu Lys His Asp Leu Leu Ile Val Ala Leu Ala 165 170 175 Leu Arg Ser Met Phe Asp Asn Asp Phe Thr Ser Met Thr Val Gly Ser 180 185 190 Asp Ala Leu Asn Thr Tyr Lys Glu Met Leu Gly Val Lys Gln Trp Glu 195 200 205 Lys Tyr Phe Pro Val Leu Ser Leu Lys Val Asn Ser Glu Ile Arg Lys 210 215 220 Ala Tyr Lys Gly Gly Phe Thr Trp Val Asn Pro Lys Tyr Gln Gly Glu 225 230 235 240 Thr Val Tyr Gly Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala 245 250 255 Met Met Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys 260 265 270 Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val 275 280 285 Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile 290 295 300 Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly 305 310 315 320 Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile 325 330 335 Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met 340 345 350 Phe Lys Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met 355 360 365 Glu Ile Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Leu Asp Glu Asn Gly Val Leu Lys Phe 405 410 415 Arg Lys Gly Glu Leu Lys Glu Arg Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Cys Phe Ile Thr Ala Tyr Ala Arg Glu Asn Ile Leu Ser Asn Ala Gln 435 440 445 Lys Leu Tyr Pro Arg Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Val 450 455 460 Glu Gly Leu Gly Glu Val Asp Ala Ile Lys Asp Val Ile Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Asp His Glu Ala Thr Phe Gln Arg Ala Arg Tyr 485 490 495 Val Arg Gln Lys Thr Tyr Phe Ile Glu Thr Thr Trp Lys Glu Asn Asp 500 505 510 Lys Gly Lys Leu Val Val Cys Glu Pro Gln Asp Ala Thr Lys Val Lys 515 520 525 Pro Lys Ile Ala Cys Ala Gly Met Ser Asp Ala Ile Lys Glu Arg Ile 530 535 540 Arg Phe Asn Glu Phe Lys Ile Gly Tyr Ser Thr His Gly Ser Leu Lys 545 550 555 560 Pro Lys Asn Val Leu Gly Gly Val Val Leu Met Asp Tyr Pro Phe Ala 565 570 575 Ile Lys <210> 8 <211> 566 <212> PRT <213> Actinomyces phage AV-1 <400> 8 Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg 1 5 10 15 Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr 20 25 30 Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val 35 40 45 Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met 50 55 60 Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asn Leu Ala 65 70 75 80 Phe Asp Gly Thr Phe Ile Leu Asp Trp Leu Leu Lys His Gly Tyr Arg 85 90 95 Trp Thr Lys Glu Asn Pro Gly Val Lys Glu Phe Thr Ser Leu Ile Ser 100 105 110 Arg Met Gly Lys Tyr Tyr Ser Ile Thr Val Val Phe Glu Thr Gly Phe 115 120 125 Arg Val Glu Phe Arg Asp Ser Phe Lys Lys Leu Pro Met Ser Val Ser 130 135 140 Ala Ile Ala Lys Ala Phe Asn Leu His Asp Gln Lys Leu Glu Ile Asp 145 150 155 160 Tyr Glu Lys Pro Arg Pro Ile Gly Tyr Ile Pro Thr Glu Gln Glu Lys 165 170 175 Arg Tyr Gln Arg Asn Asp Val Ala Ile Val Ala Gln Ala Leu Glu Val 180 185 190 Gln Phe Ala Glu Lys Met Thr Lys Leu Thr Ala Gly Ser Asp Ser Leu 195 200 205 Ala Thr Tyr Lys Lys Met Thr Gly Lys Leu Phe Ile Arg Arg Phe Pro 210 215 220 Ile Leu Ser Pro Glu Ile Asp Thr Glu Ile Arg Lys Ala Tyr Arg Gly 225 230 235 240 Gly Phe Thr Tyr Ala Asp Pro Arg Tyr Ala Lys Lys Leu Asn Gly Lys 245 250 255 Gly Ser Val Tyr Asp Val Asn Ser Leu Tyr Pro Ser Val Met Arg Thr 260 265 270 Ala Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu Gly Ala Pro Arg 275 280 285 Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe Thr Ala Lys Leu 290 295 300 Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys Asn Leu Ser Phe 305 310 315 320 Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro Thr Thr Val Val 325 330 335 Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His Tyr Asp Phe Lys 340 345 350 Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly Ser His Gly Phe 355 360 365 Phe Asp Thr Tyr Val Asp His Phe Met Glu Ile Lys Lys Asn Ser Thr 370 375 380 Gly Gly Leu Arg Gln Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly 385 390 395 400 Lys Phe Ala Thr Asn Pro Asp Ile Thr Gly Lys His Pro Thr Leu Lys 405 410 415 Asp Asn Arg Val Ser Leu Val Met Asn Glu Pro Glu Thr Arg Asp Pro 420 425 430 Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Tyr Ala Arg Lys Lys 435 440 445 Thr Ile Ser Ala Ala Gln Asp Asn Tyr Glu Thr Phe Ala Tyr Ala Asp 450 455 460 Thr Asp Ser Leu His Leu Ile Gly Pro Thr Thr Pro Pro Asp Ser Leu 465 470 475 480 Trp Val Asp Pro Val Glu Leu Gly Ala Trp Lys His Glu Ser Ser Phe 485 490 495 Thr Lys Ser Val Tyr Ile Arg Ala Lys Gln Tyr Ala Glu Glu Ile Gly 500 505 510 Gly Lys Leu Asp Val His Ile Ala Gly Met Pro Arg Asn Val Ala Ala 515 520 525 Thr Leu Thr Leu Glu Asp Met Leu His Gly Gly Thr Trp Asn Gly Lys 530 535 540 Leu Ile Pro Val Arg Val Pro Gly Gly Thr Val Leu Lys Asp Thr Thr 545 550 555 560 Phe Thr Leu Lys Ile Asp 565 <210> 9 <211> 593 <212> PRT <213> Candidatus Moranbacteria <400> 9 Met Lys Leu Lys Ser Lys Tyr Val Ala Asp Phe Glu Ala Thr Gly Glu 1 5 10 15 Glu Gln Tyr Lys Ile Asp Gly Ser Thr His Val Trp Ala Val Gly Val 20 25 30 Ile Asp Ile Glu Thr Glu Glu Thr Val Leu Ile Ser Asn Asp Ile Ala 35 40 45 Asp Phe Met Asn Trp Leu Ser Lys Asp Asn His Asn His Lys Asn Lys 50 55 60 Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys 65 70 75 80 Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr 85 90 95 Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu 100 105 110 Ile Lys Ile Cys Phe His Ala Leu Lys Thr Arg Lys Val Glu Val Lys 115 120 125 Ile His Asp Ser Tyr Lys Leu Leu Pro Phe Ser Glu Glu Lys Ile Ala 130 135 140 Lys Ala Phe Lys Leu Thr Val Ser Lys Gly Glu Ile Asp Tyr Asp Arg 145 150 155 160 Tyr Arg Pro Val Gly Tyr Gln Leu Gln Glu Tyr Glu Val Asp Tyr Leu 165 170 175 Lys Thr Asp Leu Leu Ile Met Ala Gln Ala Leu Lys Val Gln Met Asn 180 185 190 Lys Gly Leu Thr Lys Met Thr Ile Gly Ser Asn Ala Leu Ala Asp Tyr 195 200 205 Lys Gln Arg Ile Ser Lys Asp Lys Phe Lys Tyr Leu Phe Pro Val Leu 210 215 220 Asp Asn Ile Ile Asp Ala Asp Leu Arg His Ala Tyr Arg Gly Gly His 225 230 235 240 Thr Tyr Leu Gln Pro Phe Tyr Ala Asn Lys Ile Leu Glu Asn Val His 245 250 255 Ser Tyr Asp Lys Asn Ser Met His Pro Ser Gln Met Lys Asn Met Pro 260 265 270 Met Pro Tyr Gly Ile Pro Val Tyr Tyr Glu Gly Glu Tyr Lys Asn Asp 275 280 285 Pro Asp Tyr Pro Leu Phe Ile Gln Ser Ile Glu Ile Asp Cys Lys Val 290 295 300 Lys Lys Gly Tyr Leu Pro Thr Ile Gln Pro Arg Asn Ala Phe Arg Phe 305 310 315 320 Ala Thr Thr Glu Phe Leu Glu Asp Thr Lys Gly Glu Pro Ile Gln Leu 325 330 335 Phe Val Thr Ser Ile Asp Leu Met Leu Ile Leu Glu His Tyr Asp Ile 340 345 350 His Tyr Ile Gln Tyr Leu Glu Gly Phe Lys Phe Arg Ser His Ile Gly 355 360 365 Leu Phe Asp Glu Tyr Ile Asp Tyr Trp Tyr His Ile Lys Glu Thr Asn 370 375 380 Thr Gly Pro Leu Arg Glu Ile Ala Lys Leu Met Leu Asn Asn Leu Tyr 385 390 395 400 Gly Lys Phe Gly Thr Asn Pro Ile Arg Ala Arg Lys Glu Pro Ile Tyr 405 410 415 Asp Lys Thr Lys Gly Ala Val Tyr Val Asn Leu Pro Ala Glu Glu Gly 420 425 430 Asp Ala Val Tyr Ile Pro Met Ala Cys Phe Ile Thr Ala Tyr Ser Arg 435 440 445 Tyr Asp Leu Ile Ser Thr Ala Gln Lys Phe Tyr Lys Asn Val Val Tyr 450 455 460 Met Asp Thr Asp Ser Ile Lys Phe Tyr Gly Ile Ser Arg Glu Val Ile 465 470 475 480 Glu Ala Gln Ile Glu Val His Asp Thr Lys Ile Gly Ala Trp Lys Tyr 485 490 495 Glu Gly Thr Ala Lys Met Phe Lys Ala Leu Arg Pro Lys Thr Tyr Ala 500 505 510 Tyr Ile Asp Glu Asn Asp Glu Leu Asp Val Lys Cys Ala Gly Leu Pro 515 520 525 Lys Lys Ala Lys Lys Asp Ile Thr Phe Asp Thr Phe Gln Tyr Gly Phe 530 535 540 Val Ser Lys Glu Lys Leu Glu Ile Lys Arg Val Lys Gly Gly Thr Ile 545 550 555 560 Leu Leu Lys Thr Lys Phe Glu Ile Lys Lys Gln Val Asp Asn Lys His 565 570 575 Ile Asp Thr Glu Tyr Phe Glu Asp Glu Asp Ile Asp Ile Phe Asn Gln 580 585 590 Leu <210> 10 <211> 669 <212> PRT <213> Bacillus phage MG-B1 <400> 10 Met Lys Lys Lys Arg Thr Lys Thr Lys Ile Lys Thr Tyr Ala Cys Asp 1 5 10 15 Phe Glu Thr Asn Thr Glu Ala Trp Leu His Glu Asp Lys Leu Arg Asp 20 25 30 Glu Leu Lys Thr Lys Glu Glu Asn Pro Glu Leu Trp Arg Lys Arg Glu 35 40 45 Ala Trp Lys Leu His Thr Gly Gly Asp Lys Ala Phe Val Trp Ser Trp 50 55 60 Gly Gly Thr Glu Ile Arg Glu Asp Met Ser Phe Lys Gly Glu Leu Asp 65 70 75 80 Asn Phe Val Val Gly Lys Gly Ile Ser Glu Tyr Val Asp Trp Met Leu 85 90 95 Asp Gly Ser Lys Asn Val Trp Phe His Asn Leu Lys Phe Asp Gly Ser 100 105 110 Phe Ile Ala Val Glu Leu Leu Arg Arg Gly Phe Lys Phe Thr Phe Asp 115 120 125 Arg Asn Pro Ala Ile Gly Glu Phe Thr Gly Leu Ile Asp Gly Lys Lys 130 135 140 Met Trp Phe Glu Leu Ile Ile Cys Lys Glu Gly Lys Arg Gly Gly Arg 145 150 155 160 Gln Phe Ile Thr Ile Lys Asp Ser Leu Lys Lys Val Pro Phe Gly Leu 165 170 175 Arg Val Ala Ala Met Ala Phe Gly Leu Asp Val Phe Lys Asp Asp Met 180 185 190 Asp Tyr Asp Val Ile Arg Glu Pro Phe Glu Pro Ile Gly Glu Ala Asp 195 200 205 Tyr Lys Tyr Leu Lys Lys Asp Val Glu Ile Thr Ala Lys Ile Ile His 210 215 220 Tyr Gln Val Phe Gln Ser Gly Leu Lys Lys Thr Thr Ile Gly Ser Asp 225 230 235 240 Ala Leu Asn Glu Phe Lys Ser Thr Val Gly Gly Asp Lys Gly Phe Lys 245 250 255 Glu Ile Phe Pro Val Met Asp Phe Asp Thr Asp Ser Phe Ile Arg Lys 260 265 270 Ser Tyr Phe Gly Gly Val Thr Gln Val Lys Pro Gly Met Glu Gly Lys 275 280 285 Leu Ile Gly Glu Gly Ser Val Phe Asp Ile Val Ser Met Tyr Pro Trp 290 295 300 Val Gln Tyr Thr Lys Leu Leu Pro Tyr Gly Leu Pro Ile Glu Tyr Asn 305 310 315 320 Gly Glu Tyr Thr Tyr Asp Glu Glu Tyr Pro Leu Tyr Val Gln Gln Val 325 330 335 Ser Phe Ser Phe Val Val Lys Asp Asn Met Leu Pro Thr Ile Gln Leu 340 345 350 Lys Lys Gln Asn Val Glu Phe Asn Tyr Asn Glu Ala Asp Asp Val Arg 355 360 365 Lys Phe Asn Gly Arg Glu Phe Gln Lys Thr Ser Tyr Gly Glu Ile Val 370 375 380 Thr Met Tyr Val Thr Asn Val Gln Trp Glu Gln Ile Gln Lys His Tyr 385 390 395 400 Trp Leu Asp Asp Leu His Phe His Lys Gly Met Met Phe Lys Gly Lys 405 410 415 Ile Gly Leu Phe Lys Glu His Ile Asp Lys Trp Leu Lys Val Lys Lys 420 425 430 Gln Ala Asn Asp Asp Gly Asn Asp Ala Leu Lys Ser Leu Ala Lys Leu 435 440 445 Met Leu Asn Ser Pro Tyr Gly Lys Phe Gly Thr Asn Thr Ile Arg Leu 450 455 460 Asn Val Glu Pro Phe Leu Trp Glu Asp Asp Glu Ser Leu Gly Phe Arg 465 470 475 480 Val Glu Asp Asp Asp Pro Pro Pro Ala Asp Pro Ile Tyr Thr Ala Tyr 485 490 495 Ala Ser Phe Val Thr Ala Tyr Ala Arg Glu Glu Leu Val Ser Thr Ile 500 505 510 Met Met Cys Tyr Asp Arg Phe Val Tyr Cys Asp Thr Asp Ser Ile His 515 520 525 Leu Ile Gly Thr Glu Ile Pro Glu Gly Ile Lys His Lys Ile Gly Gly 530 535 540 Asp Leu Gly Asp Trp Glu Pro Glu Ser Glu Phe Lys Leu Ala Lys Phe 545 550 555 560 His Arg Ala Lys Thr Tyr Cys Glu Met Val Tyr Ala Lys Lys Val Met 565 570 575 Lys Lys Asp Arg Trp Gly Asp Val Val Glu Ser Leu Lys His Cys Ser 580 585 590 Lys Glu Glu Trp Gly Thr Leu Pro Gln Asp Gln Lys Thr Leu Asp Lys 595 600 605 Asn Leu Lys Cys Ala Gly Leu Gln Gly His Leu Lys Asp Tyr Val Ser 610 615 620 Phe Glu Glu Phe Glu Ile Gly Leu Lys Ile Asn Pro Glu Val Asn Lys 625 630 635 640 Asp Ile Met Gly Lys Pro Leu Gly Lys Leu Met Pro Cys Gln Val Lys 645 650 655 Gly Gly Thr Leu Leu Lys Val Arg Lys Phe Ser Leu Asn 660 665 <210> 11 <211> 572 <212> PRT <213> Eggerthella sp. <400> 11 Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr 1 5 10 15 Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu 20 25 30 Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile 35 40 45 Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asn Leu Lys Phe 50 55 60 Asp Gly Ser Tyr Ile Leu Ser Tyr Leu Leu Gly Val Ala Lys Trp Glu 65 70 75 80 Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Cys Leu 85 90 95 Ile Ser Ser Ile Gly Val His Tyr Asn Tyr Arg Ile Asn Phe Thr Lys 100 105 110 Arg Lys Tyr Val Lys Ile Tyr Asp Thr Leu Lys Ile Phe Asn Met Ser 115 120 125 Val Ser Gln Ile Ala Lys Ser Phe Gly Ile Lys Glu Gln Lys Gly Ser 130 135 140 Ile Asp Tyr Ala Ile Phe Arg Gly Tyr Asn Tyr Thr Met Thr Pro Lys 145 150 155 160 Glu Val Glu Tyr Ile Thr Asn Asp Val Lys Ile Val Ala Lys Ala Ile 165 170 175 Lys Gln Phe Arg Asn Glu Gly His Glu Arg Asn Thr Ile Ala Ser Asn 180 185 190 Ala Met Arg Tyr Tyr Lys Lys Asn Ser Tyr Tyr Ser Asn Tyr Glu Phe 195 200 205 Leu Thr Tyr Phe Pro His Leu Asp Asp Asp Leu Tyr His Leu Leu Lys 210 215 220 Arg Ala Tyr Lys Gly Gly Tyr Cys Tyr Val Asn Pro Lys Phe Lys Gly 225 230 235 240 Lys Pro Val Gly His Gly Arg Val Tyr Asp Val Asn Ser Leu Tyr Pro 245 250 255 Ser Val Met Ser Asp Pro Gln Asn Lys Tyr Pro Ile Gly Thr Pro Val 260 265 270 Phe Phe Glu Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile 275 280 285 Gln Phe Ile Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr 290 295 300 Ile Gln Ile Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr 305 310 315 320 Ser Thr Gly Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu 325 330 335 Glu Met Phe Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly 340 345 350 Gly Tyr Lys Phe Ile Gly Arg Ser Gly Ile Phe Ile Asp Tyr Val Asn 355 360 365 His Phe Lys Glu Met Lys Met Gln Ala Thr Ile Glu Lys Asn Ala Gly 370 375 380 Lys Arg Ser Ile Ala Lys Leu Phe Leu Asn Ser Leu Tyr Gly Lys Phe 385 390 395 400 Gly Ala Ser Asn Asp Lys Phe Val Lys Arg Pro Tyr Ile Asn Asp Lys 405 410 415 Gly Ile Leu Ala Tyr Gln Thr Val Glu Thr Pro Arg Pro Ala Lys Thr 420 425 430 Val Tyr Val Pro Val Ala Ala Phe Val Thr Ala Tyr Ala Arg Arg Phe 435 440 445 Ile Gln Thr Leu Phe Ile Lys Asn Val Asp Arg Cys Cys Tyr Cys Asp 450 455 460 Thr Asp Ser Leu His Leu Ile Gly Asp Asp Pro Pro Glu Gly Val Lys 465 470 475 480 Ile Ser Asp Thr Glu Phe Asn Cys Met Ala His Glu Ser Ser Phe Ser 485 490 495 Arg Ala Lys Phe Leu Gly Ala Lys Leu Tyr Ile Glu Glu Asp Glu Gln 500 505 510 Gly Asn Leu Asp Val Lys Ala Ala Gly Leu Gly Gln Asn Glu Val Val 515 520 525 Lys Asn Gln Ile Thr Phe Asp Asn Phe Asn Thr Glu Gln Glu Tyr Phe 530 535 540 Gly Ile Leu Lys Ser Lys Thr Val Gln Gly Gly Val Glu Leu Ser Glu 545 550 555 560 Ser Thr Phe Lys Ile Arg Glu Arg Gly Thr Arg Phe 565 570 <210> 12 <211> 568 <212> PRT <213> Streptococcus phage CP-7 <400> 12 Met Thr Cys Tyr Tyr Ala Gly Asp Phe Glu Thr Thr Thr Asn Glu Glu 1 5 10 15 Glu Thr Glu Val Trp Leu Ser Cys Phe Ala Lys Val Ile Asp Tyr Asp 20 25 30 Lys Leu Asp Thr Phe Lys Val Asn Thr Ser Leu Glu Asp Phe Leu Lys 35 40 45 Ser Leu Tyr Leu Asp Leu Asp Lys Thr Tyr Thr Glu Thr Gly Glu Asp 50 55 60 Glu Phe Ile Ile Phe Phe His Asn Leu Lys Phe Asp Gly Ser Phe Leu 65 70 75 80 Leu Ser Phe Phe Leu Asn Asn Asp Ile Glu Cys Thr Tyr Phe Ile Asn 85 90 95 Asp Met Gly Val Trp Tyr Ser Ile Thr Leu Glu Phe Pro Asp Phe Thr 100 105 110 Leu Thr Phe Arg Asp Ser Leu Lys Ile Leu Asn Phe Ser Ile Ala Thr 115 120 125 Met Ala Gly Leu Phe Lys Met Pro Ile Ala Lys Gly Thr Thr Pro Leu 130 135 140 Leu Lys His Lys Pro Asp Glu Ile Lys Pro Glu Trp Ile Asp Tyr Ile 145 150 155 160 His Val Asp Val Ala Ile Leu Ala Arg Gly Ile Phe Ala Met Tyr Tyr 165 170 175 Glu Glu Asn Phe Ser Lys Tyr Thr Ser Ala Ser Glu Ala Leu Thr Glu 180 185 190 Phe Lys Arg Ile Phe Arg Lys Ser Lys Arg Lys Phe Arg Asp Phe Phe 195 200 205 Pro Ile Leu Asp Glu Lys Val Asp Asp Phe Cys Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Trp Thr Phe Ala Asn Pro Lys Thr Gln Gly Arg Thr Leu Lys 225 230 235 240 Gln Leu Ile Asp Ile Tyr Asp Ile Asn Ser Met Tyr Pro Ala Thr Met 245 250 255 Leu Gln Asn Ala Leu Pro Ile Gly Ile Pro Lys Arg Tyr Lys Gly Lys 260 265 270 Pro Lys Glu Ile Lys Glu Asp His Tyr Tyr Ile Tyr His Ile Lys Ala 275 280 285 Asp Phe Asp Leu Lys Arg Gly Tyr Leu Pro Thr Ile Gln Ile Lys Lys 290 295 300 Lys Leu Asp Ala Leu Arg Ile Gly Val Arg Thr Ser Asp Tyr Val Thr 305 310 315 320 Thr Ser Lys Asn Glu Val Ile Asp Leu Tyr Leu Thr Asn Phe Asp Leu 325 330 335 Asp Leu Phe Leu Lys His Tyr Asp Ala Thr Ile Met Tyr Val Glu Thr 340 345 350 Leu Glu Phe Gln Thr Glu Ser Gly Leu Phe Asp Asp Tyr Ile Thr Thr 355 360 365 Tyr Arg Tyr Lys Lys Glu Asn Ala Gln Ser Pro Ala Glu Lys Gln Lys 370 375 380 Ala Lys Ile Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Ala Lys Ile 385 390 395 400 Ile Ser Val Lys Lys Leu Ala Tyr Leu Asp Asp Lys Gly Ile Leu Arg 405 410 415 Phe Lys Asn Asp Asp Glu Glu Glu Val Gln Pro Val Tyr Ala Pro Val 420 425 430 Ala Leu Phe Val Thr Ser Ile Ala Arg His Phe Ile Ile Ser Asn Ala 435 440 445 Gln Glu Asn Tyr Asp Asn Phe Leu Tyr Ala Asp Thr Asp Ser Leu His 450 455 460 Leu Phe His Ser Asp Ser Leu Val Leu Asp Ile Asp Pro Ser Glu Phe 465 470 475 480 Gly Lys Trp Ala His Glu Gly Arg Ala Val Lys Ala Lys Tyr Leu Arg 485 490 495 Ser Lys Leu Tyr Ile Glu Glu Leu Ile Gln Glu Asp Gly Thr Thr His 500 505 510 Leu Asp Val Lys Gly Ala Gly Met Thr Pro Glu Ile Lys Glu Lys Ile 515 520 525 Thr Phe Glu Asn Phe Val Ile Gly Ala Thr Phe Glu Gly Lys Arg Ala 530 535 540 Ser Lys Gln Ile Lys Gly Gly Thr Leu Ile Tyr Glu Thr Thr Phe Lys 545 550 555 560 Ile Arg Glu Thr Asp Tyr Leu Val 565 <210> 13 <211> 616 <212> PRT <213> Bacteroides sp. <400> 13 Met Ser Lys Lys Ser Ala Lys Lys Pro Val Ile Ile Ala Ala Asp Phe 1 5 10 15 Glu Thr Thr Val Tyr Pro Gly Gln Thr Ser Thr Glu Val Trp Ser Ala 20 25 30 Ala Trp Ile Glu Leu Phe Thr Glu Arg Pro His Val Arg Gly Asn Ile 35 40 45 Glu Asp Phe Leu Asn Asp Ile Phe Asn Leu Asn Lys Asn Val Leu Cys 50 55 60 Tyr Phe His Asn Leu Arg Phe Asp Gly Ala Phe Ile Val Tyr Trp Leu 65 70 75 80 Leu Lys Asn Gly Tyr Thr Trp Asn Asn Ala Arg Asn Lys Gly Met Asn 85 90 95 Ala Lys Glu Phe Lys Ala Leu Ile Ser Asp Thr Asn Lys Trp Tyr Thr 100 105 110 Val Thr Val Lys Pro Lys Phe Asp Thr Val Ile Glu Phe Arg Asp Ser 115 120 125 Val Lys Leu Met Pro Met Thr Leu Asp Gln Ile Gly Ser Ala Phe Asn 130 135 140 Thr Lys His Arg Lys Leu Glu Met Glu Tyr Ile Gly Met Arg His Ala 145 150 155 160 Asn Cys Glu Ile Thr Pro Glu Glu Tyr Ala Tyr Ile Ile Asn Asp Ile 165 170 175 Tyr Val Leu Lys Glu Ala Leu Glu Val Met Ile Lys Ser Gly His Asp 180 185 190 Lys Leu Thr Ile Gly Ser Cys Cys Met Asp Glu Phe Lys Asn Lys Phe 195 200 205 Asp Ala Met Asp Phe Lys Ala Ala Phe Pro Asn Leu Lys Glu Ile Ala 210 215 220 Leu Ile Lys Tyr Glu Leu Gly Ser Asp Asn Val Asp Gln Tyr Ile Arg 225 230 235 240 Lys Ala Tyr Lys Gly Gly Tyr Cys Tyr Tyr Lys Tyr Lys Gln Arg Lys 245 250 255 His Ile Thr Gln Asn Gly Met Thr Phe Asp Val Asn Ser Leu Tyr Pro 260 265 270 Ser Val Met His Ser Lys Ser Gly Asn Tyr Tyr Pro Thr Gly Lys Pro 275 280 285 Ile Phe Phe Glu Lys Ala Ile Pro Tyr Lys Cys Leu Glu Ala Arg Val 290 295 300 Tyr Pro Phe Tyr Val Arg Leu Arg Cys Arg Phe Lys Leu Lys Asp Gly 305 310 315 320 Phe Leu Pro Thr Val Gln Ile Lys Gly Asp Tyr Lys Tyr Asn Ser Thr 325 330 335 Gln Trp Leu Glu Thr Ser Asp Ile Tyr Tyr Arg Gly Lys Tyr Tyr Arg 340 345 350 Tyr Phe Thr Asn Lys Glu Gly Gln Lys Glu Glu Ala Arg Pro Glu Leu 355 360 365 Thr Leu Phe Met Thr Asp Tyr Leu Leu Leu Leu Glu His Tyr Asp Val 370 375 380 Tyr Asp Leu Glu Ile Leu Asp Gly Cys Tyr Phe His Gly Ala Ile Gly 385 390 395 400 Leu Phe Asp Thr Tyr Ile Asp His Tyr Met Lys Ile Lys Met Thr Thr 405 410 415 Lys Asp Lys Gly Glu Arg Thr Glu Ala Lys Leu Phe Leu Asn Asn Leu 420 425 430 Tyr Gly Arg Leu Ala Ile Asn Asp Asn Ser Ser Tyr Arg Glu Pro Phe 435 440 445 Ile Asp Pro Glu Thr Asp Ser Ile Gly Phe Glu Leu His Pro Glu His 450 455 460 Glu Lys Asp Thr Leu Tyr Ile Ala Ala Gly Ala Ala Val Thr Ala Tyr 465 470 475 480 Ala Arg Tyr Phe Thr Ile Thr His Ala Gln Ala Asn Tyr Gln Asn Phe 485 490 495 Val Tyr Ser Asp Thr Asp Ser Ile His Met Leu Asp Asp Gly Gln Pro 500 505 510 Val Lys Met Ile Lys Glu His Ala Thr Glu Leu Leu His Trp Lys Arg 515 520 525 Glu Ser Asp Trp Ser Ser Ala Ile Phe Ile Arg Gln Lys Thr Tyr Ala 530 535 540 Glu Phe Val Gln Lys Glu Asp Gly Lys Lys Val Thr Gly His Trp Glu 545 550 555 560 Ile Lys Cys Ala Gly Met Pro Glu Lys Ser Lys Lys Leu Phe Leu Ala 565 570 575 Ser His Pro Ile Thr Asp Phe Lys Ile Gly Leu Lys Val Gly Gly Lys 580 585 590 Leu Lys Pro Lys Tyr Ile Ser Gly Gly Met Val Leu Val Glu Asp Phe 595 600 605 Tyr Thr Leu Arg Ala Lys Arg Cys 610 615 <210> 14 <211> 641 <212> PRT <213> Chlamydia trachomatis <400> 14 Met Lys Ala Arg Lys Phe Lys Ile Tyr Ala Ala Asp Phe Glu Thr Thr 1 5 10 15 Val Phe Lys Gly Gln Thr Phe Thr Glu Val Trp Ser Ala Cys Phe Cys 20 25 30 Glu Leu Tyr Lys Lys Asp Ala Lys Ile Met His Ser Ile Gln Asp Phe 35 40 45 Phe Asn Tyr Phe Phe Ser Leu Asn Glu Asn Ile Lys Met Tyr Phe His 50 55 60 Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Ser Tyr Leu Leu Lys Asp 65 70 75 80 Leu Lys Tyr Glu Gln Ala Tyr Glu Lys Met Asn Ala Asp Gly Ser Leu 85 90 95 Val Arg Trp Leu Glu Thr Lys Asp Met Lys Asn Asn Ser Ile Lys Tyr 100 105 110 Ser Ile Ser Glu Met Gly Gln Trp Tyr Tyr Ile Ile Ile Lys Lys Asn 115 120 125 Asn Lys Ile Ile Glu Ile Arg Asp Ser Leu Lys Leu Leu Pro Phe Ser 130 135 140 Leu Glu Ala Ile Gly Lys Ser Phe Asp Thr Glu His Lys Lys Leu Lys 145 150 155 160 Met Lys Tyr Glu Gly Tyr Arg Tyr Ala Gly Cys Glu Ile Thr Pro Glu 165 170 175 Glu Gln Ala Tyr Ile Lys Asn Asp Val Leu Val Leu Lys Glu Ala Leu 180 185 190 Glu Ile Met Phe Asn Glu Lys His Glu Ser Leu Thr Ile Gly Ser Cys 195 200 205 Cys Leu Asn Glu Tyr Lys Thr Ile Met Thr Lys Phe Leu Ile Glu Arg 210 215 220 Leu Tyr Pro Asn Ile Ala Glu Tyr Thr Val Asn Val Pro Leu Glu Phe 225 230 235 240 Lys Asn Ala Asp Glu Tyr Val Arg Lys Ser Tyr Lys Gly Gly Trp Cys 245 250 255 Tyr Leu Lys Lys Gly Cys Glu Asn Lys Ile Tyr Asn Asn Gly Thr Thr 260 265 270 Ala Asp Val Asn Ser Leu Tyr Ser Ser Val Met His Ser Glu Ser Gly 275 280 285 Asn Tyr Tyr Pro Val Gly Leu Pro Thr Phe Trp Ser Gly Asn Tyr Ile 290 295 300 Pro Glu Ile Ala Lys Glu Lys Tyr Tyr Phe Ile Arg Ile Lys Thr Arg 305 310 315 320 Phe Tyr Leu Lys Lys Arg Phe Leu Pro Cys Ile Gln Val Lys Asn Thr 325 330 335 Tyr Arg Tyr Lys Ser Thr Glu Trp Leu Glu Thr Ser Asp Phe Tyr Asp 340 345 350 Lys Lys Thr Asn Lys Tyr Tyr Lys Lys Tyr Leu Asp Ile Asn Gly Asn 355 360 365 Glu Gln Asn Thr Gln Val Ile Leu Thr Leu Thr Met Thr Asp Phe Glu 370 375 380 Leu Ile Lys Glu His Tyr Asn Leu Val Asp Phe Glu Ile Leu Asp Gly 385 390 395 400 Cys Tyr Phe Asp Lys Glu Ile Gly Leu Phe Asp Glu Tyr Ile Asn Lys 405 410 415 Tyr Lys Lys Ile Lys Leu Asn Ser Lys Gly Ala Lys Lys Thr Leu Ala 420 425 430 Lys Leu Tyr Leu Asn Asn Leu Tyr Gly Lys Thr Ala Thr Asn Thr Asp 435 440 445 Ser Ser Phe Lys Val Ala Tyr Ile Lys Asp Asp Leu Ser Leu Gly Phe 450 455 460 Tyr Gly Val Tyr Ala Cys Asp Lys Lys Pro Phe Tyr Ile Pro Val Gly 465 470 475 480 Ser Ala Ile Thr Ser Tyr Ala Arg Asn Phe Thr Ile Arg Ala Ala Gln 485 490 495 Lys Asn Tyr Lys Asn Phe Ile Tyr Ala Asp Thr Asp Ser Ile His Cys 500 505 510 Lys Cys Asn Pro Ala Glu Ile Lys Gly Ile Thr Ile Asp Asp Lys Lys 515 520 525 Phe Leu Cys Trp Lys Leu Glu Ser Cys Trp Asp Lys Gly Leu Phe Val 530 535 540 Arg Gln Lys Thr Tyr Ile Glu His Ile Thr Ala Glu Asn Leu Lys Pro 545 550 555 560 Ile Asp Lys Pro Phe Tyr Asn Val Lys Cys Ala Gly Met Pro Glu Gln 565 570 575 Cys Lys Thr Leu Phe Leu Lys Ser Ile Gly Glu Asp Val Asp Ile Ser 580 585 590 Asp Leu Asn Ile Asn Asp Asp Ala Lys Glu Phe Leu Lys Lys Lys Arg 595 600 605 Thr Ile Lys Asp Phe Lys Ala Gly Leu Ser Val Pro Leu Lys Leu Arg 610 615 620 Pro Val Gln Ile Asn Gly Gly Val Leu Leu Thr Glu Thr Phe Tyr Thr 625 630 635 640 Met <210> 15 <211> 574 <212> PRT <213> Globodera pallida <400> 15 Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg 1 5 10 15 Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg 20 25 30 Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu 35 40 45 Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn 50 55 60 Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu 65 70 75 80 Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro 85 90 95 Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr 100 105 110 Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp 115 120 125 Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe 130 135 140 Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro 145 150 155 160 Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp 165 170 175 Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met 180 185 190 Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met 195 200 205 Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile 210 215 220 Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp 225 230 235 240 Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val 245 250 255 Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly 260 265 270 Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His 275 280 285 Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly 290 295 300 His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr 305 310 315 320 Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn 325 330 335 Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala 340 345 350 Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp 355 360 365 Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg 370 375 380 Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys 405 410 415 Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val 420 425 430 Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr 435 440 445 Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr 450 455 460 Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys 465 470 475 480 Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His 485 490 495 Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr 500 505 510 Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp 515 520 525 Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu 530 535 540 Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr 545 550 555 560 Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile 565 570 <210> 16 <211> 584 <212> PRT <213> Globodera sp. <400> 16 Met Pro Leu Pro Arg Lys Lys Ala Ser Ser Asn Gly Leu Ser Lys Arg 1 5 10 15 Ile Tyr Leu Ala Asp Phe Glu Thr Thr Thr Gln Ala Glu Asp Cys Arg 20 25 30 Val Trp Ser Trp Gly Leu Cys Ser Val Glu Asn Thr Glu Asn Val Glu 35 40 45 Phe Gly Gly Asp Leu Asp Ser Phe Ile Glu Arg Ile Ser Glu Glu Asn 50 55 60 Ser Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu 65 70 75 80 Asp Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro 85 90 95 Gln Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr 100 105 110 Ser Ile Lys Val Arg Trp Glu Asn Gly Met Phe Thr Glu Phe Arg Asp 115 120 125 Ser Leu Lys Lys Leu Pro Met Ser Val Lys Gln Val Ala Lys Thr Phe 130 135 140 Lys Leu Asp Gln Ala Lys Gly Glu Ile Asp Tyr His Tyr Leu Arg Pro 145 150 155 160 Val Gly Trp Val Met Thr Pro Glu Glu Arg Glu Tyr Val Lys Asn Asp 165 170 175 Val Gln Ile Val Ala Arg Ala Leu Lys Val Gln Leu Gln Glu Gly Met 180 185 190 Thr Arg Leu Thr Val Gly Ala Asp Ser Leu Ala Gln Tyr Lys Ser Met 195 200 205 Met Gly Lys Asp Phe Glu Arg His Phe Pro Val Leu Thr Arg Thr Ile 210 215 220 Asp Ala Glu Ile Arg Arg Ala Tyr Arg Gly Gly Trp Ala Tyr Ala Asp 225 230 235 240 Glu Arg His Arg Gly Lys Val Val Gly Ala Gly Gln Thr Phe Asp Val 245 250 255 Asn Ser Leu Tyr Pro Ser Val Met Tyr Ser Lys Val Leu Pro Tyr Gly 260 265 270 Glu Pro Val Phe Tyr Pro Asn Gly Leu Pro Glu Val Thr Glu Asp His 275 280 285 Pro Leu Phe Ile Thr Cys Ile Thr Phe Thr Ala Lys Ile Arg Asp Gly 290 295 300 His Leu Pro Cys Ile Gln Ile Lys Asn Ser Ser Leu Phe Thr Pro Thr 305 310 315 320 Glu Tyr Val Lys Glu Val Leu Asp Pro Ile Thr Met Tyr Cys Thr Asn 325 330 335 Val Asp Leu Glu Leu Trp Gln Glu His Tyr Asp Met Asp Ile Leu Ala 340 345 350 Tyr Asn Gly Ala Trp Leu Phe Arg Gly Ile Arg Gly Phe Phe Asn Asp 355 360 365 Tyr Ile Asp His Trp Met Arg Ile Lys Glu Glu Ser Glu Gly Gly Arg 370 375 380 Lys Leu Ile Ala Lys Leu His Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Thr Asn Pro Asp Val Thr Pro Lys Ile Pro Ile Phe Asp Glu Glu Lys 405 410 415 Asp Ile Val Arg Leu Ile Glu Gly Pro Pro Asp Glu Arg Asn Pro Val 420 425 430 Tyr Thr Ala Met Gly Val Phe Ile Thr Ser Tyr Ala Arg Asp Leu Thr 435 440 445 Ile Arg Thr Ala Gln Asp His Tyr Asp Arg Phe Leu Tyr Ala Asp Thr 450 455 460 Asp Ser Leu His Leu Leu Thr Ser Asp Gly Thr Asn Asn Gly Arg Lys 465 470 475 480 Ser Lys Ala Leu Glu Val His Pro Ser Lys Leu Gly Tyr Trp Lys His 485 490 495 Glu Tyr Asp Phe Asp Ala Gly Leu Phe Val Arg Ala Lys Ala Tyr Thr 500 505 510 Glu Leu Met Thr Gly Glu Phe His Val Lys Ser Lys Cys Glu Cys Asp 515 520 525 Thr Pro Asn Asp Leu His Tyr Gln Thr His Ile Ala Gly Met Pro Glu 530 535 540 Ala Ile Ala Gln His Ile Thr Phe Glu Ser Tyr Arg Asp Gly Ala Thr 545 550 555 560 Phe Glu Gly Lys Leu Ala Pro Gln Arg Val Pro Gly Gly Ile Val Leu 565 570 575 Val Asp Asp Thr Phe Thr Ile Lys 580 <210> 17 <211> 548 <212> PRT <213> Lynx pardinus <220> <221> misc_feature <222> (339)..(374) <223> Xaa can be any naturally occurring amino acid <400> 17 Met Pro Ser Tyr Thr Ala Asp Phe Glu Thr Thr Thr Val Ala Asp Asp 1 5 10 15 Cys Arg Val Trp Ala Trp Ala Thr Ser Arg Ile Gly Asn Pro Asp Asp 20 25 30 Val Gln Leu Gly Asn Ser Ile Asp Thr Phe Leu Glu Trp Cys Arg Val 35 40 45 His Ser Gly Ser Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys 50 55 60 Phe Ile Leu His Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp 65 70 75 80 Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met 85 90 95 Ser Gln Phe Tyr Ser Ile Lys Leu Trp Phe Asp Glu Ser Lys Ser Ile 100 105 110 Glu Phe Leu Asp Ser Leu Lys Val Ile Pro Leu Pro Ile Ala Ala Ile 115 120 125 Pro Lys Ala Phe Gly Leu Glu Ile Glu Lys Leu Asp Leu Asp Tyr Gln 130 135 140 Ala Ser Arg Glu Val Gly His Glu Leu Thr Glu Asp Glu Lys Glu Tyr 145 150 155 160 Ile Ala His Asp Val Lys Ile Ala Ala Met Ala Met Asp Thr Met Phe 165 170 175 Ser Gln Gly Met Lys Lys Ile Thr Ala Gly Ser Asn Ala Phe Ala Asp 180 185 190 Tyr Lys Lys Thr Ile Gly Gly Lys Lys Arg Phe Arg Asp Trp Phe Pro 195 200 205 Glu Pro Glu Tyr Asp Glu Asp Leu Arg Lys Gly Gly Cys Tyr Lys Gly 210 215 220 Gly Phe Thr Ala Val Asn Pro Lys Ile Ala Gly Lys Lys Leu Gly Lys 225 230 235 240 Gly Val Ser Phe Asp Val Asn Ser Leu Tyr Pro Ser Val Met Ala Ser 245 250 255 Ser His Gly Glu Val Leu Pro Tyr Gly Glu Pro Ile Pro Tyr Asp Gly 260 265 270 Gly Tyr Glu Gln Asp Glu Asp His Pro Leu Tyr Ile Gln Phe Ile Glu 275 280 285 Ala Asp Phe Ala Val Lys Glu Asn Arg Ile Pro Cys Leu Gln Leu Lys 290 295 300 Gly Asn Val Met Phe Gly Glu Thr Glu Tyr Ile Arg Asp Ser Lys Gly 305 310 315 320 Met Gln Thr Leu Cys Leu Thr Ser Val Asp Met Glu Met Leu Phe Glu 325 330 335 His Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 340 345 350 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 355 360 365 Xaa Xaa Xaa Xaa Xaa Xaa Arg Thr Ile Ala Lys Leu Gln Leu Asn Ser 370 375 380 Leu Phe Ala Ala Asn Pro Val Lys Gln Ser Arg Met Pro Tyr Leu Asp 385 390 395 400 Glu Gly Ile Val Lys Tyr Ala Leu Leu Glu Pro Glu His Ala Glu Ala 405 410 415 Gln Tyr Leu Pro Ala Gly Ala Phe Ile Thr Ser Tyr Ala Arg Gln Phe 420 425 430 Thr Ile Arg Ala Ala Gln Ala Asn Tyr Glu Arg Trp Leu Tyr Cys Asp 435 440 445 Thr Asp Ser Val Tyr Leu Arg Gly Thr Glu Pro Pro Val Asp Met Arg 450 455 460 Val Asp Ala Tyr Glu Leu Gly Ala Trp Lys Lys Glu His Glu Phe Asp 465 470 475 480 Cys Phe Lys Ala Ile Arg Ala Lys Thr Tyr Cys Phe Glu Glu Asp Gly 485 490 495 Glu Leu Thr Val His Cys Ala Gly Met Pro Ala Arg Cys His Glu His 500 505 510 Val Thr Met Asp Asn Phe Glu Val Gly Ala Ser Phe Pro Gly Lys Leu 515 520 525 Lys Pro Lys Asp Val Asn Gly Gly Thr Ile Leu Val Glu Asp Val Phe 530 535 540 Thr Ile Arg Pro 545 <210> 18 <211> 611 <212> PRT <213> Enterococcus faecium (SK) <400> 18 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys 65 70 75 80 Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr 100 105 110 Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp 195 200 205 Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro 275 280 285 Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly 465 470 475 480 Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 485 490 495 Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His 565 570 575 His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu 595 600 605 Trp His Glu 610 <210> 19 <211> 646 <212> PRT <213> Bacillus phage Harambe <400> 19 Met Gly Asn Lys Lys Arg Lys Ile Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Leu Met Glu Ile 20 25 30 Asp Gly Lys Phe Glu Asn Tyr Lys Glu Gly Asn Asn Ile Asp Glu Phe 35 40 45 Met Glu Trp Thr Glu Gln Glu Gln Gly Asp Leu Tyr Phe His Asn Leu 50 55 60 Arg Phe Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys Gly Tyr 65 70 75 80 Arg Phe Asn Asn Thr Arg Lys Ala Gly Thr Phe Asn Ala Val Ile Ser 85 90 95 Ser Met Gly Gln Trp Tyr Lys Ile Asp Ile Tyr Tyr Gly Arg Glu Gly 100 105 110 Lys Lys Val Phe Lys Thr Ser Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Ile Glu Lys 130 135 140 Gly Asp Ile Asp Tyr Asp Ala Pro Arg Pro Val Gly His Gln Ile Thr 145 150 155 160 Pro Asp Glu Ser Lys Tyr Ile Lys Asn Asp Val Glu Ile Ile Ala Arg 165 170 175 Ala Leu His Ser Gln Leu Asn Thr Ala Lys Leu Thr Lys Met Thr Ile 180 185 190 Gly Ser Asp Ala Leu Asp Gly Phe Lys His Ser Leu His Lys Ser Pro 195 200 205 Lys Val Ser Lys Arg Met Tyr Asp His His Phe Pro Val Ile Ser Asn 210 215 220 Ala Ile His Glu Glu Phe Lys Lys Ala Tyr Arg Gly Gly Phe Thr Trp 225 230 235 240 Ala Asn Pro Lys Tyr Ala Gly Lys Val Ile Gly Asn Gly Leu Val Phe 245 250 255 Asp Val Asn Ser Leu Tyr Pro Ser Val Met Tyr Asp Lys Pro Leu Pro 260 265 270 Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu Tyr Glu Tyr Asp Glu Thr 275 280 285 His Pro Leu Phe Ile Gln His Ile Lys Cys Gly Phe Glu Leu Lys Asp 290 295 300 Gly His Ile Pro Thr Ile Gln Ile Lys Lys Asn Phe Arg Phe Ala Asp 305 310 315 320 Asn Glu Tyr Leu His Ser Ser Glu Gly Asn Ile Leu Asp Leu His Val 325 330 335 Thr Asn Val Asp Leu Ala Leu Ile Lys Glu His Tyr Thr Leu Tyr Glu 340 345 350 Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys Gln Val Thr Gly Leu Phe 355 360 365 Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys Lys Ile Asn Ala Glu Asp 370 375 380 Pro Ala Ile Arg Gln Met Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly 385 390 395 400 Lys Phe Gly Thr Ser Ile Asp Val Thr Gly Lys Glu Val Phe Leu Lys 405 410 415 Glu Asp Gly Ser Thr Gly Phe Arg Lys Gly Gln Lys Glu Glu Arg Asp 420 425 430 Pro Val Tyr Met Pro Met Gly Ala Phe Ile Thr Ala Tyr Ala Arg Asp 435 440 445 Val Thr Ile Arg Thr Ala Gln Lys Cys Tyr Asp Arg Ile Leu Tyr Cys 450 455 460 Asp Thr Asp Ser Ile His Leu Val Gly Thr Glu Ile Pro Glu Ala Ile 465 470 475 480 Lys Asp Arg Ile His Asp Lys Lys Leu Gly Tyr Trp Ala His Glu Ser 485 490 495 Thr Phe Trp Arg Ala Lys Phe Ile Arg Gln Lys Thr Tyr Ile Glu Asp 500 505 510 Leu Cys Met Arg Phe Glu Gly Glu Lys Val Asn Gly Glu Trp Lys Phe 515 520 525 Lys Met Val Glu Glu Lys Asp Ile Thr Lys Ala Thr Ala Arg Glu Leu 530 535 540 Ser Val Lys Cys Ala Gly Met Pro Ala Gln Val Lys Gln Tyr Val Thr 545 550 555 560 Phe Asp Asn Phe Gly Val Asp Phe Lys His Asp Pro Asn Asp Tyr Thr 565 570 575 Asp Glu Glu Ile Lys Arg Lys Asn Ile Lys Phe Lys Leu Lys Pro Thr 580 585 590 His Arg Lys Gly Gly Gln Val Leu Val Pro Thr Pro Phe Thr Ile Lys 595 600 605 Gly His His His His His His His His His His Gly Gly Gly Ser Gly 610 615 620 Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln 625 630 635 640 Lys Ile Glu Trp His Glu 645 <210> 20 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 20 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 21 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 21 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Glu Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Lys Leu Lys Glu 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 22 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 22 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 23 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 23 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Glu Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Ala Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp Gly Tyr Leu Lys Glu 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 24 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 24 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 25 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 25 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 26 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 26 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 27 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 27 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Ile His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Leu Ser Thr Lys Lys Phe Asn Lys Val Phe 195 200 205 Pro Lys Leu Ser Leu Pro Met Asp Lys Glu Ile Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ser Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Val Lys 355 360 365 Thr His Glu Tyr Gly Ala Lys Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly Phe Arg Val Gly Asp Glu 405 410 415 Glu Tyr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ile Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Lys Gly Tyr Leu Lys Gln 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Thr Ile Lys Lys Lys Val Thr Phe Asp Asn Phe Ala 530 535 540 Val Gly Phe Ser Ser Met Gly Lys Pro Lys Pro Val Gln Val Asn Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 28 <211> 589 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 28 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 20 25 30 Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 35 40 45 Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 65 70 75 80 Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 85 90 95 Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 100 105 110 Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 145 150 155 160 Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 180 185 190 Lys Asp Ala Leu Asp Glu Phe Val Asn Met Ser Gly Lys Leu Tyr Glu 195 200 205 Lys Leu Phe Pro Val Phe Ser Leu Glu Leu Asn Glu Glu Ile Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Pro Val Tyr Gly Gly Lys 225 230 235 240 Lys Tyr Val Lys Asp Gly Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro 245 250 255 Ser Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 260 265 270 Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 275 280 285 Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 290 295 300 Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 305 310 315 320 Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 325 330 335 Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 340 345 350 Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Arg Gln Tyr Ile Asp Lys 355 360 365 Trp Met Leu Val Lys Asn Met Ser Tyr Gly Ala Lys Lys Ala Ile Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Arg Pro Tyr Leu Arg Glu Asp Gly Ser Asn Gly Phe 405 410 415 Glu Leu Met Glu Glu Glu Phe Arg Asp Pro Val Tyr Thr Pro Val Gly 420 425 430 Ile Phe Ile Thr Ser Trp Ala Arg Tyr Thr Thr Ile Thr Ser Ala Gln 435 440 445 Lys Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Met His Leu 450 455 460 Glu Gly Leu Asp Val Pro Glu Ser Ile Lys Asp Ile Val Ala Asp Asp 465 470 475 480 Val Leu Gly Tyr Trp Glu Lys Glu Gly Gln Phe Lys Gln Gly Lys Phe 485 490 495 Ile Arg Gln Lys Thr Tyr Met Glu Glu Tyr Tyr Ala Lys Tyr Val Arg 500 505 510 Asp Glu Asn Gly Glu Ile Lys Tyr Asp Asp Glu Lys Pro Tyr Lys Thr 515 520 525 Ile Cys Asp Lys Glu Glu Ser Asp Thr Thr Ile Ile Glu Ile Lys Cys 530 535 540 Ala Gly Met Pro Asp Asn Ile Lys Lys His Val Thr Phe Asp Asn Phe 545 550 555 560 Asp Ile Gly Phe Thr Met Glu Gly Lys Leu Lys Pro Lys Gln Val Tyr 565 570 575 Gly Gly Val Val Leu Val Glu Glu Thr Tyr Thr Met Lys 580 585 <210> 29 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 29 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 30 <211> 592 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 30 Met Ala Thr Lys Lys Arg Lys Ala Tyr Ser Cys Asp Phe Glu Ala Thr 1 5 10 15 Thr Ser Thr Tyr Ser Glu Thr Glu Thr Arg Val Trp Ala Tyr Gly Trp 20 25 30 Met Glu Ile Gly Asn Thr Ser His Phe Asn Ile Gly Asp Asn Leu Asp 35 40 45 Glu Phe Met Leu Trp Thr Ser Lys Glu Cys Ala Asp Leu Tyr Phe His 50 55 60 Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn Trp Leu Leu His Lys 65 70 75 80 Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys Thr Phe Asp Thr Val 85 90 95 Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala Ile His His Glu Gly 100 105 110 Lys Gly Thr Thr Gln Ile Phe Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Lys Thr Ile Ala Lys Ala Phe Lys Leu Pro Val Leu Lys Gly Asp 130 135 140 Ile Asp Ile Asn Leu His Arg Asp Glu Asn His Val Ile Thr Ser Glu 145 150 155 160 Glu Phe Thr Tyr Ile Lys His Asp Ile Glu Ile Val Ala Arg Ala Leu 165 170 175 Asp Ile Gln Ile Asn Gln Gln Gly Leu Val Lys Met Thr Asn Gly Ala 180 185 190 Asp Ser Met Asp His Phe Ile Lys Ser Leu Asp Lys Lys Lys Lys Val 195 200 205 Ala Glu Arg Ile Tyr Asn Gln Tyr Phe Pro Lys Met Ser Ile Ala Met 210 215 220 Asp Ser Ile Phe Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Val Asn 225 230 235 240 Pro Lys Phe Lys Gly Gln Glu Val Gly Glu Gly Met Val Phe Asp Ala 245 250 255 Asn Ser Ala Tyr Pro Ser Val Met Tyr Tyr Lys Pro Leu Pro Trp Gly 260 265 270 Lys Pro Val Pro Phe Val Gly Lys Tyr Glu Glu Asp Pro Asp Phe Pro 275 280 285 Leu Tyr Ile Cys His Ile Lys Thr Gly Phe Val Leu Lys Glu Gly His 290 295 300 Ile Pro Thr Ile Gln Ile Lys Lys Asn Pro Ile Phe Gln Glu Asn Glu 305 310 315 320 Tyr Leu Glu Thr Ser Gly Gly Ala Pro Val Asp Leu His Val Thr Asn 325 330 335 Val Asp Leu Glu Leu Ile Lys Glu His Tyr Glu Leu Tyr Asp Thr Glu 340 345 350 Tyr Val Gly Gly Trp Lys Phe Arg Gln Gln Thr Gly Ile Phe Asn Asn 355 360 365 Phe Ile Asp Tyr Trp Met Lys Ile Lys Thr Asp Pro Lys Ser Thr Pro 370 375 380 Ala Ile Val Thr Leu Ala Lys Leu Gln Leu Asn Ser Leu Tyr Gly Lys 385 390 395 400 Phe Ala Ser His Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp 405 410 415 Asp Gly Ser Thr Ala Phe Lys Lys Gly Leu Pro Lys Ser Lys Asp Pro 420 425 430 Val Tyr Thr Pro Ala Gly Ala Phe Ile Thr Ala Trp Ala Arg His Met 435 440 445 Thr Ile Thr Thr Ala Gln Lys Val Tyr Asp Arg Ile Leu Tyr Cys Asp 450 455 460 Thr Asp Ser Ile His Ile Leu Gly Ile Asp Ile Pro Glu Ala Ile Lys 465 470 475 480 Asn Asp Ile His Gln Lys Glu Leu Gly Lys Trp Glu Phe Glu Cys Met 485 490 495 Phe Lys Arg Ala Lys Phe Val Arg Gln Lys Thr Tyr Val Glu Asp Met 500 505 510 Tyr Ala Lys Phe Met Lys Tyr Trp Glu Asp Gly Glu Leu Asn Tyr Tyr 515 520 525 Leu Lys Glu Cys Val Lys Glu Glu Ala Thr Ala Arg Leu Leu Asn Val 530 535 540 Lys Cys Ala Gly Met Pro Gln Ala Val Lys Lys Phe Val Thr Phe Arg 545 550 555 560 Thr Phe Ala Val Gly Phe Thr Ser Asp Thr Gly Lys Leu Lys Pro Lys 565 570 575 His Val Lys Gly Gly Gln Ile Leu Val Asp Val Pro Phe Thr Ile Lys 580 585 590 <210> 31 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 31 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 32 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 32 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 33 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 33 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 34 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 34 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 35 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 35 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser Ala Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 36 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 36 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 37 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 37 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 38 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 38 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Thr 370 375 380 Glu Val Lys Thr Thr Thr Tyr Gly Ala Arg Lys Gln Leu Ala Lys Leu 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 39 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 39 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Tyr Gly Ala Arg Lys Gln Asn Ala Lys Leu 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 565 570 <210> 40 <211> 591 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 40 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Gln Asp Trp 195 200 205 Val Lys Thr Thr Tyr Gly Lys Ser Arg Phe Lys Gln Trp Phe Pro Val 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Glu Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu 275 280 285 Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 465 470 475 480 Thr Glu Val Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu 485 490 495 Gly Tyr Trp Lys His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Tyr Met Lys Arg Val Lys Gly Tyr 515 520 525 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Glu Leu Asn Val 530 535 540 Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp 545 550 555 560 Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg 565 570 575 Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys 580 585 590 <210> 41 <211> 611 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 41 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Asp Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Lys 65 70 75 80 Glu Thr Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Glu Val Asn Tyr Thr Thr Thr 100 105 110 Lys Ser Gly Lys Thr Lys Lys Glu Lys Val Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Gln Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Ile Thr Lys Glu Arg Pro 145 150 155 160 Val Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Tyr Lys Asp Trp 195 200 205 Leu Lys Ala Thr His Gly Lys Ser Thr Phe Lys Gln Trp Phe Pro Ile 210 215 220 Leu Ser Leu Gly Phe Asp Lys Asp Leu Arg Lys Ala Tyr Lys Gly Gly 225 230 235 240 Phe Thr Trp Val Asn Lys Val Phe Gln Gly Lys Glu Ile Gly Asp Gly 245 250 255 Ile Val Phe Asp Val Asn Ser Leu Tyr Pro Ser Gln Met Tyr Val Arg 260 265 270 Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Pro 275 280 285 Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg 290 295 300 Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu 305 310 315 320 Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys Leu Gly Val 325 330 335 Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Phe 340 345 350 Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met 355 360 365 Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp Ile Asp Lys Trp Ile 370 375 380 Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys Ala Asn Ala Lys Gly 385 390 395 400 Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp Ile Thr 405 410 415 Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu Thr Leu 420 425 430 Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Val Pro Leu Ala Ser Phe 435 440 445 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Arg Cys 450 455 460 Phe Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Val Gly 465 470 475 480 Thr Asp Val Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu 485 490 495 Gly Tyr Trp Gly His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg 500 505 510 Gln Lys Thr Tyr Val Glu Glu Ile Asp Gly Glu Leu Asn Val Lys Cys 515 520 525 Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr Phe Asp Asn Phe 530 535 540 Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro Lys Arg Thr Gln 545 550 555 560 Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile Lys Gly His His 565 570 575 His His His His His His His His Gly Gly Gly Ser Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys Ile Glu 595 600 605 Trp His Glu 610 <210> 42 <211> 613 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 42 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 565 570 575 His His His His His His His His His His Gly Gly Gly Ser Gly Gly 580 585 590 Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 595 600 605 Ile Glu Trp His Glu 610 <210> 43 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 43 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 44 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 44 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Lys Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 45 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 45 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 46 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 46 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 47 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 47 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Arg Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 48 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 48 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Arg Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 49 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 49 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Arg Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 50 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 50 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Asp Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 51 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 51 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 52 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 52 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Asp Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 53 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 53 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 54 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 54 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 55 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 55 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Cys His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 56 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 56 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ser His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 57 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 57 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Thr His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 58 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 58 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 59 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 59 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 60 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 60 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser Leu Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Ala Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 61 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 61 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 62 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 62 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Asn His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 63 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 63 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Gln His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 64 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 64 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Phe 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 65 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 65 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Lys Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 66 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 66 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ser 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 67 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 67 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Asp Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 68 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 68 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Trp Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 69 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 69 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Trp Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 70 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 70 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Phe Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 71 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 71 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Ala Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 72 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 72 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Arg Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 73 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 73 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Asp 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 74 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 74 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Glu 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Lys 465 470 475 480 Gly Tyr Trp Ala His Ala Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 75 <211> 613 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 75 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 565 570 575 His His His His His His His His His His Gly Gly Gly Ser Gly Gly 580 585 590 Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 595 600 605 Ile Glu Trp His Glu 610 <210> 76 <211> 613 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 76 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys Gly 565 570 575 His His His His His His His His His His Gly Gly Gly Ser Gly Gly 580 585 590 Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 595 600 605 Ile Glu Trp His Glu 610 <210> 77 <211> 613 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 77 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys Gly 565 570 575 His His His His His His His His His His Gly Gly Gly Ser Gly Gly 580 585 590 Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala Gln Lys 595 600 605 Ile Glu Trp His Glu 610 <210> 78 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 78 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 79 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 79 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 80 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 80 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 81 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 81 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 82 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 82 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 83 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 83 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 84 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 84 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 85 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 85 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 86 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 86 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Glu Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 87 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 87 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 88 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 88 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 89 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 89 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 90 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 90 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 91 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 91 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Asn Val Asn Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 92 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 92 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 93 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 93 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 94 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 94 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 500 505 510 Leu Val Glu Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 95 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 95 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val His Gly Lys 500 505 510 Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 96 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 96 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Lys Leu Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Tyr 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Glu Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Val Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Phe 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Pro Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys His Val Asp Gly Lys 500 505 510 Leu Val Asn Gly Ser Pro Asp Asp Tyr Thr Lys Ile Lys Leu Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Asp Thr Phe Thr Ile Lys 565 570 575 <210> 97 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 97 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 98 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 98 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 99 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 99 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 100 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 100 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 260 265 270 Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 101 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 101 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 260 265 270 Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 275 280 285 Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 305 310 315 320 Val Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 102 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 102 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 260 265 270 Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 275 280 285 Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 305 310 315 320 Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala 340 345 350 Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 103 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 103 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 104 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 104 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Arg Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Leu Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Asn Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Leu Val Asn Trp Leu Glu Gln His Gly Phe Arg Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 260 265 270 Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 275 280 285 Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Asp Leu 305 310 315 320 Val Glu Leu Trp Ile Ser Gln Val Asp Ile Asp Leu Met Lys Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Ile Lys Phe Arg Ala 340 345 350 Thr Thr Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 105 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 105 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Ile Leu Pro Tyr Gly Asp Pro Ile Val Phe Asp Gly Lys Tyr 260 265 270 Val Trp Asp Asp Glu Tyr Pro Leu His Ile Gln His Ile Arg Cys Asp 275 280 285 Phe Glu Leu Lys Asp Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Leu 305 310 315 320 Val Glu Leu Tyr Val Thr Asn Ile Asp Leu Asp Leu Ile Lys Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Leu Ser Gly Leu Lys Phe Arg Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 106 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 106 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 107 <211> 582 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 107 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile 195 200 205 Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 210 215 220 Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 225 230 235 240 Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 245 250 255 Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr 260 265 270 Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr 275 280 285 Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly 290 295 300 Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn 305 310 315 320 Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser 325 330 335 Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val 340 345 350 Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys 355 360 365 Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala 370 375 380 Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe 385 390 395 400 Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn 405 410 415 Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val 420 425 430 Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr 435 440 445 Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr 450 455 460 Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp 465 470 475 480 Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe 485 490 495 Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr 500 505 510 Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr 515 520 525 Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile 530 535 540 Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys 545 550 555 560 Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp 565 570 575 Glu Thr Phe Thr Ile Lys 580 <210> 108 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 108 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 109 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 109 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 110 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 110 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 111 <211> 587 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 111 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Asp Arg Met Thr Ala Gly Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile 195 200 205 Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 210 215 220 Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 225 230 235 240 Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 245 250 255 Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr 260 265 270 Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr 275 280 285 Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg Phe Arg Leu Lys Glu Arg 290 295 300 His Ile Pro Thr Ile Gln Val Lys Gln Ser Ser Leu Phe Ile Gln Asn 305 310 315 320 Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu Gly Val Asp Glu Leu Ile 325 330 335 Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu His Tyr 340 345 350 Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser 355 360 365 Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr 370 375 380 Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser 385 390 395 400 Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro 405 410 415 Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu 420 425 430 Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp 435 440 445 Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile 450 455 460 Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro 465 470 475 480 Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu 485 490 495 His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr 500 505 510 Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly 515 520 525 Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly 530 535 540 Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val 545 550 555 560 Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly 565 570 575 Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 580 585 <210> 112 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 112 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 113 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 113 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 114 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 114 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln 260 265 270 Gly Lys Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile 275 280 285 Arg Phe Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Lys Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly 305 310 315 320 Val Glu Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile 325 330 335 Gln Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys 340 345 350 Phe Arg Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 115 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 115 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys Tyr 260 265 270 Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys Asn 290 295 300 Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu Pro 305 310 315 320 Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu His 325 330 335 Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg Glu 340 345 350 Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 116 <211> 576 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 116 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 20 25 30 Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 35 40 45 Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 65 70 75 80 Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 85 90 95 Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 100 105 110 Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 145 150 155 160 Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 180 185 190 Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 260 265 270 Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 275 280 285 Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 290 295 300 Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 305 310 315 320 Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 325 330 335 Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 340 345 350 Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 355 360 365 Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 370 375 380 Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 385 390 395 400 Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 405 410 415 Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 420 425 430 Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 435 440 445 Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 450 455 460 Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys 465 470 475 480 Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 485 490 495 Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 500 505 510 Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 515 520 525 Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe 530 535 540 Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 545 550 555 560 Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 117 <211> 576 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 117 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe Glu 260 265 270 Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys Leu 275 280 285 Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln Leu 290 295 300 Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser Ser 305 310 315 320 Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu Leu 325 330 335 Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly Trp 340 345 350 Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys Trp 355 360 365 Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 370 375 380 Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 385 390 395 400 Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 405 410 415 Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 420 425 430 Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 435 440 445 Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 450 455 460 Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys 465 470 475 480 Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 485 490 495 Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 500 505 510 Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 515 520 525 Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe 530 535 540 Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 545 550 555 560 Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 118 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 118 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Asp Val Asn Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Ile 20 25 30 Gly Lys Thr Ser Asn Tyr Lys Ile Gly Thr Asp Phe Asn Glu Phe Met 35 40 45 Glu Trp Met Ile His Ser Ser Ser Arg Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ser Phe Ile Val Asn Trp Leu Leu His Asn Gly Tyr Thr 65 70 75 80 Trp Thr Lys Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Leu Ile Ser 85 90 95 Lys Met Gly Gln Trp Tyr Gly Ile Thr Ile Cys Ser Gly Arg Asp Gly 100 105 110 Arg Lys Lys Lys Leu Thr Thr Ile His Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Arg Lys Ile Gly Lys Asp Phe Lys Leu Asn Val Leu Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Pro Arg Pro Ile Gly Tyr Glu Ile Asp 145 150 155 160 Asp Glu Glu Tyr Gln Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Glu Val Gln Thr Val Gln Gly Leu Thr Gly Met Thr Asn Gly 180 185 190 Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Asp Arg Asp Leu Pro Cys Gly Val Pro Ile Pro Phe 260 265 270 Glu Gly Glu Tyr Val Tyr Asp Lys Ser His Pro Leu Tyr Ile Gln Lys 275 280 285 Leu Thr Phe Glu Phe Glu Leu Lys Glu Asn Tyr Ile Pro Thr Ile Gln 290 295 300 Leu Lys Asn Ser Arg Phe Gly Phe Lys Gly Asn Glu Tyr Leu Ser Ser 305 310 315 320 Ser Asn Gly Glu Arg Ile Thr Ile Ser Val Ser Ser Val Asp Trp Glu 325 330 335 Leu Ile Arg Glu His Tyr His Val Tyr Asp Val Glu Phe Glu Lys Gly 340 345 350 Trp Lys Phe Arg Ser Thr Lys Gln Ala Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 119 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 119 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Phe Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 120 <211> 582 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 120 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asn Glu Lys Phe Asp Gly 50 55 60 Glu Phe Met Leu Ser Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly 85 90 95 Gln Trp Tyr Ala Leu Glu Ile Cys Trp Asn Val Lys Cys Thr Thr Thr 100 105 110 Lys Thr Gly Lys Thr Lys Lys Glu Lys Gln Arg Thr Ile Ile Tyr Asp 115 120 125 Ser Leu Lys Lys Tyr Pro Phe Pro Val Lys Glu Ile Ala Glu Ala Phe 130 135 140 Asn Phe Pro Ile Lys Lys Gly Glu Ile Asp Tyr Thr Lys Glu Arg Pro 145 150 155 160 Ile Gly Tyr Asn Pro Thr Asp Asp Glu Trp Asp Tyr Leu Lys Asn Asp 165 170 175 Ile Gln Ile Met Ala Met Ala Leu Lys Ile Gln Phe Asp Gln Gly Leu 180 185 190 Thr Arg Met Thr Arg Gly Ser Asp Ala Leu Gly Asp Phe Lys Asp Ile 195 200 205 Ile Thr Thr Lys Lys Phe Lys Lys Val Phe Pro Thr Leu Ser Leu Gly 210 215 220 Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu 225 230 235 240 Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly Glu Gly Met Val Phe Asp 245 250 255 Ala Asn Ser His Tyr Pro Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr 260 265 270 Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr 275 280 285 Pro Leu His Ile Gln His Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly 290 295 300 Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn 305 310 315 320 Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser 325 330 335 Asn Val Asp Leu Glu Leu Met Lys Glu His Tyr Asp Leu Tyr Asn Val 340 345 350 Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys 355 360 365 Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala 370 375 380 Ile Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe 385 390 395 400 Ala Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn 405 410 415 Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val 420 425 430 Tyr Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr 435 440 445 Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr 450 455 460 Asp Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp 465 470 475 480 Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe 485 490 495 Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr 500 505 510 Met Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr 515 520 525 Thr Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile 530 535 540 Lys Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys 545 550 555 560 Met Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp 565 570 575 Glu Thr Phe Thr Ile Lys 580 <210> 121 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 121 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ala Ile Glu His Leu Val Asp Ser Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 122 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 122 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 123 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 123 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 124 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 124 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Val 450 455 460 Pro Glu Ala Ile Glu His Leu Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Gln Arg Ala Lys Phe Ile Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Val Lys Lys Val Arg Gly Tyr Leu Val Gln 500 505 510 Cys Ser Pro Asp Glu Ala Thr Thr Thr Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 125 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 125 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg Ser 290 295 300 Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 126 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 126 Met Ile Lys Lys Tyr Thr Gly Asp Phe Glu Thr Thr Thr Asp Leu Asn 1 5 10 15 Asp Cys Arg Val Trp Ser Trp Gly Val Cys Asp Ile Asp Asn Val Asp 20 25 30 Asn Ile Thr Phe Gly Leu Glu Ile Asp Ser Phe Phe Glu Trp Cys Glu 35 40 45 Met Gln Gly Ser Thr Asp Ile Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 127 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 127 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 128 <211> 596 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 128 Met Val Arg Gln Ser Thr Ile Ala Ser Pro Ala Arg Gly Gly Val Arg 1 5 10 15 Arg Ser His Lys Lys Val Pro Ser Phe Cys Ala Asp Phe Glu Thr Thr 20 25 30 Thr Asp Glu Asp Asp Cys Arg Val Trp Ser Trp Gly Ile Ile Gln Val 35 40 45 Gly Lys Leu Gln Asn Tyr Val Asp Gly Ile Ser Leu Asp Gly Phe Met 50 55 60 Ser His Ile Ser Glu Arg Ala Ser His Ile Tyr Phe His Asp Leu Lys 65 70 75 80 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 85 90 95 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 100 105 110 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 115 120 125 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 130 135 140 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 145 150 155 160 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 165 170 175 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 180 185 190 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 195 200 205 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 210 215 220 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 225 230 235 240 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 245 250 255 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 260 265 270 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 275 280 285 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 290 295 300 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 305 310 315 320 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 325 330 335 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 340 345 350 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 355 360 365 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 370 375 380 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 385 390 395 400 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 405 410 415 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 420 425 430 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 435 440 445 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 450 455 460 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 465 470 475 480 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 485 490 495 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 500 505 510 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 515 520 525 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 530 535 540 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 545 550 555 560 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 565 570 575 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 580 585 590 Phe Thr Ile Lys 595 <210> 129 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 129 Met Asn Glu Tyr Ile Ser Asp Phe Glu Thr Gln Lys Asp Pro Asp Thr 1 5 10 15 Gly Val Met Ser Val Trp Ala Trp Ser Ile Val Asp Val Asn Asp Leu 20 25 30 Ser Asn Ile Gln Tyr Gly Asn Asn Ile Glu Ser Trp Leu Ser Ala Ile 35 40 45 Gln Gly Leu Pro Asn Gly Ser Leu Ile Gly Phe His Asp Leu Lys Phe 50 55 60 Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp 65 70 75 80 Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 290 295 300 Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 565 570 575 Thr Ile Lys <210> 130 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 130 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 131 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 131 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Gly Trp 355 360 365 Ile Asp Lys Trp Ile Glu Val Lys Asn Thr Thr Glu Gly Ala Arg Lys 370 375 380 Ala Asn Ala Lys Gly Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 530 535 540 Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 545 550 555 560 Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 565 570 575 Phe Thr Ile Lys 580 <210> 132 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 132 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 385 390 395 400 Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile 405 410 415 Val Arg Leu Thr Leu Gly Glu Glu Glu Leu Arg Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 530 535 540 Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 545 550 555 560 Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 565 570 575 Phe Thr Ile Lys 580 <210> 133 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 133 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Tyr Ser Glu 260 265 270 Gly Ala Pro Arg Thr Asn Arg Pro Leu Tyr Ile Ala Ser Ile Thr Phe 275 280 285 Thr Ala Lys Leu Lys Pro Asn His Ile Pro Cys Ile Gln Ile Lys Lys 290 295 300 Asn Leu Ser Phe Asn Pro Thr Gln Tyr Leu Glu Glu Val Lys Glu Pro 305 310 315 320 Thr Thr Val Val Ala Thr Asn Ile Asp Ile Glu Leu Trp Lys Lys His 325 330 335 Tyr Asp Phe Lys Ile Tyr Ser Trp Asn Gly Thr Phe Glu Phe Arg Gly 340 345 350 Ser His Gly Phe Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Glu Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 <210> 134 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 134 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Ile Gly Thr Pro Val Phe Phe Glu 260 265 270 Gly Lys Tyr Lys Asp Asp Pro Ile Tyr Pro Leu Tyr Ile Gln Phe Ile 275 280 285 Thr Ala Gln Phe Glu Leu Lys Lys Gly Lys Ile Pro Thr Ile Gln Ile 290 295 300 Lys Asn Asp Lys Arg Phe Asn Pro Arg Glu Tyr Val Thr Ser Thr Gly 305 310 315 320 Cys Leu Met Val Asn Leu Tyr Leu Thr Asn Val Asp Leu Glu Met Phe 325 330 335 Tyr Glu Cys Tyr Asn Ile Lys Glu Ile Gln Tyr Ile Gly Gly Tyr Lys 340 345 350 Phe Ile Gly Arg Ser Gly Ile Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile Lys 565 570 575 <210> 135 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 135 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 136 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 136 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 137 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 137 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 138 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 138 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Thr Leu Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 139 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 139 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 140 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 140 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 141 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 141 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 142 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 142 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 143 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 143 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 144 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 144 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 145 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 145 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 146 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 146 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 147 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 147 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 148 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 148 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 149 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 149 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 150 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 150 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 151 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 151 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 152 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 152 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 153 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 153 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 154 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 154 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 155 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 155 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 156 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 156 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 157 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 157 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 158 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 158 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 159 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 159 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 160 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 160 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 161 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 161 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 162 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 162 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 163 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 163 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 164 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 164 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 165 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 165 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 166 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 166 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 167 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 167 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 168 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 168 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 169 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 169 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 170 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 170 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 171 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 171 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 172 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 172 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 173 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 173 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 174 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 174 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 175 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 175 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 176 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 176 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 177 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 177 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 178 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 178 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 179 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 179 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 180 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 180 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 181 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 181 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 182 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 182 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 183 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 183 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 184 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 184 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Glu Val Asp 500 505 510 Gly Lys Leu Lys Glu Cys Ser Pro Asp Glu Ala Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 185 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 185 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Val Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Arg Cys Phe Asp Asn Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 186 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 186 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Lys Asp Phe Gln Leu Pro Leu Leu Lys Gly Asp Ile Asp 130 135 140 Tyr His Thr Glu Arg Pro Val Gly His Glu Ile Thr Pro Glu Glu Tyr 145 150 155 160 Glu Tyr Ile Lys Asn Asp Ile Glu Ile Ile Ala Arg Ala Leu Asp Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Val Lys Arg Val Asp 500 505 510 Gly Tyr Leu Val Glu Cys Ser Pro Asp Glu Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 187 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 187 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 188 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 188 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 189 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 189 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 190 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 190 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 191 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 191 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 192 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 192 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 193 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 193 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Phe Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 194 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 194 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Thr Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Phe Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 195 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 195 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 196 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 196 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 197 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 197 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 145 150 155 160 Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 198 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 198 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 145 150 155 160 Ala Tyr Leu Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 199 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 199 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Ile Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Phe Gly Tyr Lys Gly Lys Arg Lys Leu 100 105 110 His Thr Ile Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Leu Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Asp Glu Tyr 145 150 155 160 Ala Tyr Leu Lys Asn Asp Ile Gln Ile Leu Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 200 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 200 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 201 <211> 616 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 201 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys Gly His His His His His His His His His His Gly Gly Gly 580 585 590 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 595 600 605 Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 202 <211> 616 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 202 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys 65 70 75 80 Arg Pro Ser Lys Glu Gly Gln Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys Gly His His His His His His His His His His Gly Gly Gly 580 585 590 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 595 600 605 Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 203 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 203 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu 65 70 75 80 Ser Gly Arg Pro Lys Thr Phe Asp Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 204 <211> 616 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 204 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys 65 70 75 80 Glu Asn Pro Gly Val Lys Glu Phe Thr Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys Gly His His His His His His His His His His Gly Gly Gly 580 585 590 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 595 600 605 Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 205 <211> 616 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 205 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys Gly His His His His His His His His His His Gly Gly Gly 580 585 590 Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu 595 600 605 Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 206 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 206 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Thr Ala 65 70 75 80 Glu Gly Glu Pro Asn Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 207 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 207 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Lys Asn Gly Phe Lys Trp Thr Ala 65 70 75 80 Glu Gly Leu Pro Arg Thr Tyr Ser Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 208 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 208 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Tyr Lys Trp Thr Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 209 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 209 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Lys Asn Gly Tyr Lys Trp Thr Ala 65 70 75 80 Glu Gly Leu Pro Lys Thr Phe Ser Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 210 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 210 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Arg Asn Gly Tyr Val His Thr Glu 65 70 75 80 Glu Asp Arg Thr Asn Thr Pro Lys Glu Phe Thr Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 211 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 211 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp 65 70 75 80 Glu Lys Ala Pro Gln Val Lys Glu Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 290 295 300 Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 565 570 575 Thr Ile Lys <210> 212 <211> 618 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 212 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Thr Asp Gly Trp Lys Trp Ile Pro 65 70 75 80 Asp Lys Asn Asp Cys Ala Asn Arg Thr Phe Thr Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys Gly His His His His His His His His His His Gly 580 585 590 Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe 595 600 605 Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 213 <211> 617 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 213 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Glu Asn Gly Phe Lys His Ser Arg 65 70 75 80 Glu Arg Ala Leu Tyr Ser Asn Glu Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys 290 295 300 Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe 565 570 575 Thr Ile Lys Gly His His His His His His His His His His Gly Gly 580 585 590 Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe 595 600 605 Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 214 <211> 619 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 214 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn 65 70 75 80 Asp Lys Pro Lys Ala Arg Lys Ala Lys Thr Val Glu Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Lys Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu 565 570 575 Thr Phe Thr Ile Lys Gly His His His His His His His His His His 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp 595 600 605 Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu 610 615 <210> 215 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 215 Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ser Tyr Gly Trp Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 216 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 216 Met Ser Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Val Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 217 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 217 Met Ser Arg Lys Val Phe Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 218 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 218 Met Ser Arg Lys Val Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Trp Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 219 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 219 Met Ser Arg Lys Met Tyr Thr Ala Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asp Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 220 <211> 615 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 220 Met Ser Arg Lys Met Tyr Ser Ala Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ser Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys Gly His His His His His His His His His His Gly Gly Gly Ser 580 585 590 Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp Phe Phe Glu Ala 595 600 605 Gln Lys Ile Glu Trp His Glu 610 615 <210> 221 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 221 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 222 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 222 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Asn His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 223 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 223 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Phe Tyr Ile Lys Thr Thr Ser Glu Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Gln His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 224 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 224 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Phe Tyr Ile Lys Thr Arg Ser Glu Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Ala His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 225 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 225 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 226 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 226 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 227 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 227 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 228 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 228 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 229 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 229 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 230 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 230 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 231 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 231 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 232 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 232 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 233 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 233 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 234 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 234 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 235 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 235 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 236 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 236 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 237 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 237 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys <210> 238 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 238 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys <210> 239 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 239 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 240 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 240 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys <210> 241 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 241 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 242 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 242 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 243 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 243 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 244 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 244 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 245 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 245 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 246 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 246 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Gln His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Phe Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 247 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 247 Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 248 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 248 Met His Lys Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met 35 40 45 Gln Trp Val Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 249 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 249 Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 250 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 250 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 251 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 251 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 252 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 252 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 253 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 253 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 254 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 254 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 255 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 255 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 256 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 256 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Thr Leu Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 257 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 257 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 258 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 258 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Leu Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 259 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 259 Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 Asp Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr 565 570 575 Phe Thr Ile Lys 580 <210> 260 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 260 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 261 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 261 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 262 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 262 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Thr Ile Asp Glu Phe Met Gln Trp Ile 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 263 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 263 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 264 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 264 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 265 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 265 Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 266 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 266 Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 267 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 267 Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 268 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 268 Met His Lys Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Gln Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 269 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 269 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 270 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 270 Met His Lys Met Ser Lys Lys Met Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Val 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Asn Ile Asp Glu Phe Met 35 40 45 Gln Trp Ile Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 271 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 271 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 272 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 272 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 273 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 273 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 274 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 274 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 275 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 275 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 276 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 276 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 277 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 277 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 325 330 335 Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 278 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 278 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 325 330 335 Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 279 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 279 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp 325 330 335 Val Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 280 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 280 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 281 <211> 579 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 281 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe Phe His Asp Leu Lys Phe Asp 50 55 60 Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys 65 70 75 80 Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met 85 90 95 Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg 100 105 110 Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro 115 120 125 Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp 130 135 140 Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu 145 150 155 160 Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu 165 170 175 Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp 180 185 190 Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys 195 200 205 Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala 210 215 220 Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu 225 230 235 240 Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln 245 250 255 Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly 260 265 270 Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys 275 280 285 Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys 290 295 300 Gln Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn 305 310 315 320 Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp 325 330 335 Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr 340 345 350 Tyr Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile 355 360 365 Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln 370 375 380 Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn 385 390 395 400 Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu 405 410 415 Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro 420 425 430 Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr 435 440 445 Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile 450 455 460 His Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His 465 470 475 480 Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala 485 490 495 Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg 500 505 510 Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile 515 520 525 Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu 530 535 540 Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro 545 550 555 560 Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe 565 570 575 Thr Ile Lys <210> 282 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 282 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 283 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 283 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 284 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 284 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 285 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 285 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 286 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 286 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 287 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 287 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 288 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 288 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 289 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 289 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 290 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 290 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 291 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 291 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 292 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 292 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Gly Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 293 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 293 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 294 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 294 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Leu His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 295 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 295 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 296 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 296 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 297 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 297 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ser Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 298 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 298 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 299 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 299 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 300 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 300 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys 260 265 270 Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys 275 280 285 Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys 340 345 350 Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 301 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 301 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met 245 250 255 Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu 260 265 270 Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 275 280 285 Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 290 295 300 Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 305 310 315 320 Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 325 330 335 His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 340 345 350 Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile 355 360 365 Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 420 425 430 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 302 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 302 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 275 280 285 Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 290 295 300 Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 305 310 315 320 Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 325 330 335 His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 340 345 350 Gly Phe Ile Gly Phe Phe Asp Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 303 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 303 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Ser Arg Pro Leu Pro Tyr Gly Ala Pro Ile Val Phe Gln Gly Lys 260 265 270 Tyr Glu Lys Asp Glu Gln Tyr Pro Leu Tyr Ile Gln Arg Ile Arg Phe 275 280 285 Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Lys 290 295 300 Asn Pro Phe Phe Lys Gly Asn Glu Tyr Leu Lys Asn Ser Gly Val Glu 305 310 315 320 Pro Val Glu Leu Tyr Leu Thr Asn Val Asp Leu Glu Leu Ile Gln Glu 325 330 335 His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Asp Gly Phe Lys Phe Arg 340 345 350 Glu Lys Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 304 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 304 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 305 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 305 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Pro Asn Asn Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Asp Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Glu Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 306 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 306 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 307 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 307 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 308 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 308 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 309 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 309 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 340 345 350 Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 310 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 310 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 311 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 311 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Leu Leu Pro Tyr Gly Glu Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 340 345 350 Ala Thr Thr Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 312 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 312 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 313 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 313 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 314 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 314 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 315 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 315 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 316 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 316 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 317 <211> 574 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 317 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Leu Pro Val Pro Phe Ser Gly Glu 260 265 270 Tyr Glu Tyr Asp Glu Thr His Pro Leu Phe Ile Gln His Ile Lys Cys 275 280 285 Gly Phe Glu Leu Lys Asp Gly His Ile Pro Thr Ile Gln Ile Lys Lys 290 295 300 Asn Phe Arg Phe Ala Asp Asn Glu Tyr Leu His Ser Ser Glu Gly Asn 305 310 315 320 Ile Leu Asp Leu His Val Thr Asn Val Asp Leu Ala Leu Ile Lys Glu 325 330 335 His Tyr Thr Leu Tyr Glu Glu Glu Tyr Leu Gln Gly Tyr Lys Phe Lys 340 345 350 Gln Val Thr Gly Leu Phe Lys Asn Tyr Ile Asp Tyr Trp Ser Asp Lys 355 360 365 Lys Ile Asn Ala Glu Asp Pro Ala Ile Arg Gln Met Ala Lys Leu Met 370 375 380 Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly 385 390 395 400 Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly 405 410 415 Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val 420 425 430 Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr 435 440 445 Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr 450 455 460 Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly 465 470 475 480 Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln 485 490 495 Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu 500 505 510 Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys 515 520 525 Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn 530 535 540 Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val 545 550 555 560 Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 318 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 318 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 319 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 319 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 320 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 320 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 321 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 321 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 322 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 322 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 323 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 323 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Val Asn Ser Met Tyr Pro Ala Met Met 245 250 255 Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys Gly Glu 260 265 270 Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val Arg Cys 275 280 285 Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile Lys Gly 290 295 300 Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly Asp Glu 305 310 315 320 Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile Lys Lys 325 330 335 His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met Phe Lys 340 345 350 Gly Phe Ile Gly Phe Phe Asp Glu Tyr Ile Asp Arg Phe Met Glu Ile 355 360 365 Lys Asn Ser Pro Asp Ser Ser Ala Glu Gln Ser Leu Gln Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 420 425 430 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 324 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 324 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 325 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 325 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 326 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 326 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Tyr Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 327 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 327 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 328 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 328 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Lys Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 329 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 329 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 330 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 330 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 331 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 331 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 332 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 332 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 333 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 333 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 334 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 334 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 335 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 335 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 336 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 336 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 337 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 337 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 338 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 338 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 339 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 339 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 340 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 340 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 341 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 341 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 342 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 342 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ile Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Thr Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 343 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 343 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Lys Asn Lys Leu Leu Pro Tyr Gly Glu Pro Val Met Phe Lys 260 265 270 Gly Glu Tyr Lys Lys Asn Val Glu Tyr Pro Leu Tyr Ile Gln Gln Val 275 280 285 Arg Cys Phe Phe Glu Leu Lys Lys Asp Lys Ile Pro Cys Ile Gln Ile 290 295 300 Lys Gly Asn Ala Arg Phe Gly Gln Asn Glu Tyr Leu Ser Thr Ser Gly 305 310 315 320 Asp Glu Tyr Val Asp Leu Tyr Val Thr Asn Val Asp Trp Glu Leu Ile 325 330 335 Lys Lys His Tyr Asp Ile Phe Glu Glu Glu Phe Ile Gly Gly Phe Met 340 345 350 Phe Lys Gly Met Phe Lys Asp Phe Ile Asp Lys Trp Phe Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe Val Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 344 <211> 576 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 344 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 260 265 270 Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 275 280 285 Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 290 295 300 Ile Lys Arg Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 305 310 315 320 Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 325 330 335 Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 340 345 350 Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 355 360 365 Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 370 375 380 Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 385 390 395 400 Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 405 410 415 Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser 420 425 430 Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala 435 440 445 Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 450 455 460 Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys 465 470 475 480 Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 485 490 495 Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys Gly 500 505 510 Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 515 520 525 Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe 530 535 540 Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 545 550 555 560 Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 345 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 345 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 346 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 346 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 347 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 347 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 348 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 348 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser 290 295 300 Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 349 <211> 576 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 349 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe 260 265 270 Glu Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His 275 280 285 Ile Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln 290 295 300 Ile Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser 305 310 315 320 Gly Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu 325 330 335 Met Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu 340 345 350 Lys Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp 355 360 365 Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys 370 375 380 Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val 385 390 395 400 Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg 405 410 415 Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val 420 425 430 Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala 435 440 445 Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr 450 455 460 Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys 465 470 475 480 Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu 485 490 495 Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly 500 505 510 Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser 515 520 525 Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe 530 535 540 Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val 545 550 555 560 Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 350 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 350 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 351 <211> 572 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 351 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys Tyr 260 265 270 Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys Glu 275 280 285 Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln Ser 290 295 300 Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu Ile 305 310 315 320 Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu His 325 330 335 Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys Ala 340 345 350 Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile Lys 355 360 365 Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu Asn 370 375 380 Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys Val 385 390 395 400 Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu Glu 405 410 415 Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr Ala 420 425 430 Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp Arg 435 440 445 Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys Ile 450 455 460 Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr Trp 465 470 475 480 Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys Thr 485 490 495 Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val Gln 500 505 510 Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys Ala 515 520 525 Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe Lys 530 535 540 Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro Gly 545 550 555 560 Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 352 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 352 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu Gly Lys 260 265 270 Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile Arg Cys 275 280 285 Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln 290 295 300 Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys Phe Lys 340 345 350 Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 353 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 353 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 420 425 430 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 354 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 354 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 355 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 355 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala Ser Phe 420 425 430 Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 356 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 356 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp Tyr Pro Leu His Ile Gln His Ile 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Asp Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Asp Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Lys Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 357 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 357 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 358 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 358 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 359 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 359 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 360 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 360 Met Lys His Met Pro Arg Lys Met Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Val Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 361 <211> 575 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 361 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Ser Arg Leu Leu Pro Tyr Gly Glu Pro Ile Val Phe Glu 260 265 270 Gly Lys Tyr Val Trp Asp Glu Asp His Pro Leu His Ile Gln His Leu 275 280 285 Arg Cys Glu Phe Glu Leu Lys Glu Gly Tyr Ile Pro Cys Ile Gln Ile 290 295 300 Lys Gln Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly 305 310 315 320 Gly Glu Ile Ala Glu Leu Trp Leu Ser Asn Val Asp Leu Glu Leu Met 325 330 335 Lys Glu His Tyr Glu Leu Tyr Asn Val Glu Tyr Ile Ser Gly Leu Lys 340 345 350 Phe Arg Ala Thr Thr Gly Leu Phe Lys Asp Phe Ile Asp Lys Trp Thr 355 360 365 Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu 370 375 380 Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr 385 390 395 400 Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu 405 410 415 Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe 420 425 430 Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys 435 440 445 Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly 450 455 460 Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys Lys Leu 465 470 475 480 Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg 485 490 495 Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr 500 505 510 Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val 515 520 525 Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu 530 535 540 Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln 545 550 555 560 Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 575 <210> 362 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 362 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 363 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 363 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 364 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 364 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 365 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 365 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 366 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 366 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 367 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 367 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 368 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 368 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 369 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 369 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 370 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 370 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 371 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 371 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Val Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 372 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 372 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 373 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 373 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 374 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 374 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 375 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 375 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 376 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 376 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gln His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 377 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 377 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 378 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 378 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 379 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 379 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 380 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 380 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Val Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Gly Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 381 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 381 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Asp Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 382 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 382 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Leu Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 383 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 383 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Val Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Ile Thr Leu Thr Asn Val Asp Val 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 384 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 384 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 385 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 385 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 386 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 386 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 387 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 387 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 388 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 388 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 389 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 389 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 390 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 390 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 391 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 391 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 392 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 392 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 393 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 393 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 394 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 394 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 395 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 395 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys <210> 396 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 396 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 397 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 397 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 398 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 398 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 399 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 399 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 400 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 400 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr 565 570 575 Ile Lys <210> 401 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 401 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 402 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 402 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Arg Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Asp Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 403 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 403 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 404 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 404 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Glu 115 120 125 Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Asn 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Asn Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Glu Ile Pro Asp Val Ile Lys Asp Ile Val Asp Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Lys 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Lys Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Glu Thr Phe Thr Ile 565 570 575 Lys <210> 405 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 405 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 406 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 406 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 407 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 407 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 408 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 408 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 409 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 409 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 410 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 410 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 411 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 411 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 412 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 412 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 413 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 413 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Glu Lys Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Glu Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 414 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 414 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 415 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 415 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 416 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 416 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 417 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 417 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 418 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 418 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 419 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 419 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 420 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 420 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 421 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 421 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 422 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 422 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 423 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 423 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 424 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 424 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 425 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 425 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 426 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 426 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 427 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 427 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 428 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 428 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn 275 280 285 Leu Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 429 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 429 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 430 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 430 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 431 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 431 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 432 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 432 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 433 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 433 Met Lys His Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 434 <211> 581 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 434 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys 65 70 75 80 Trp Cys Lys Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser 85 90 95 Arg Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly 100 105 110 Lys Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro 115 120 125 Phe Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys 130 135 140 Gly Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr 145 150 155 160 Pro Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu 165 170 175 Ala Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly 180 185 190 Ser Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe 195 200 205 Lys Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg 210 215 220 Lys Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly 225 230 235 240 Lys Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro 245 250 255 Ala Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr 260 265 270 Glu Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn 275 280 285 Ile Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln 290 295 300 Val Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser 305 310 315 320 Val Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn 325 330 335 Val Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His 340 345 350 Tyr Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp 355 360 365 Phe Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile 370 375 380 Lys Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala 385 390 395 400 Ser Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly 405 410 415 Ala Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr 420 425 430 Thr Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile 435 440 445 Thr Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp 450 455 460 Ser Ile His Leu Thr Gly Thr Lys Val Pro Asp Ala Ile Lys Asp Leu 465 470 475 480 Val His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys 485 490 495 Arg Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Val Gln Asp Ile Tyr Met 500 505 510 Lys Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr 515 520 525 Asp Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys 530 535 540 Glu Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met 545 550 555 560 Lys Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser 565 570 575 Val Phe Thr Ile Lys 580 <210> 435 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 435 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 436 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 436 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 437 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 437 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 438 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 438 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 439 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 439 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 440 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 440 Met Lys His Met Ser Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn Leu Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 441 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 441 Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 1 5 10 15 Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 442 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 442 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 20 25 30 Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 443 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 443 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 35 40 45 Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 444 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 444 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 20 25 30 Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 35 40 45 Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 445 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 445 Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 1 5 10 15 Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Ala Trp Ala 35 40 45 Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 446 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 446 Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr Thr Lys Val 1 5 10 15 Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile Glu Asp His 20 25 30 Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp 385 390 395 400 Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe 405 410 415 Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 447 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 447 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn Leu Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 448 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 448 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Leu Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile 20 25 30 Gly Asn His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Gln Trp Ala Met Lys Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser 385 390 395 400 Asn Pro Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala 405 410 415 Leu Gly Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Met Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Ala Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu 530 535 540 Glu Val Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys 545 550 555 560 Pro Lys Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val 565 570 575 Phe Thr Ile Lys 580 <210> 449 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 449 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 450 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 450 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 385 390 395 400 Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 405 410 415 Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val 530 535 540 Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu 545 550 555 560 Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr 565 570 575 Ile Lys <210> 451 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 451 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 385 390 395 400 Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 405 410 415 Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 452 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 452 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro 385 390 395 400 Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg 405 410 415 Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val 530 535 540 Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu 545 550 555 560 Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr 565 570 575 Ile Lys <210> 453 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 453 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly 420 425 430 Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 454 <211> 580 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 454 Met Lys His Met Pro Arg Lys Arg Tyr Ser Cys Asp Phe Glu Thr Thr 1 5 10 15 Thr Lys Val Glu Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Asn Ile 20 25 30 Glu Asp His Ser Glu Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met 35 40 45 Ala Trp Ala Leu Lys Val Gln Ala Asp Leu Tyr Phe His Asn Leu Lys 50 55 60 Phe Asp Gly Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys 65 70 75 80 Trp Ser Ala Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg 85 90 95 Met Gly Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys 100 105 110 Arg Lys Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe 115 120 125 Pro Val Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly 130 135 140 Asp Ile Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro 145 150 155 160 Glu Glu Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala 165 170 175 Leu Leu Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser 180 185 190 Asp Ser Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys 195 200 205 Lys Val Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys 210 215 220 Ala Tyr Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys 225 230 235 240 Glu Ile Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala 245 250 255 Gln Met Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu 260 265 270 Gly Glu Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile 275 280 285 Lys Val Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val 290 295 300 Lys Gln Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val 305 310 315 320 Asn Lys Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val 325 330 335 Asp Leu Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr 340 345 350 Thr Tyr Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe 355 360 365 Ile Asp Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys 370 375 380 Gln Leu Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr 385 390 395 400 Asn Pro Asp Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile 405 410 415 Val Arg Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr 420 425 430 Pro Leu Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr 435 440 445 Thr Ala Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser 450 455 460 Ile His Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val 465 470 475 480 His Pro Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg 485 490 495 Ala Lys Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys 500 505 510 Arg Val Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp 515 520 525 Ile Lys Phe Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu 530 535 540 Leu Val Thr Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys 545 550 555 560 Leu Leu Pro Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met 565 570 575 Phe Thr Ile Lys 580 <210> 455 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 455 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr 530 535 540 Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro 545 550 555 560 Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile 565 570 575 Lys <210> 456 <211> 577 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 456 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala 65 70 75 80 Asp Gly Leu Pro Asn Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln 85 90 95 Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys Ile 100 105 110 His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val Lys 115 120 125 Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile Asp 130 135 140 Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu Tyr 145 150 155 160 Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu Ile 165 170 175 Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser Leu 180 185 190 Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val Phe 195 200 205 Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr Arg 210 215 220 Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile Gly 225 230 235 240 Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met Tyr 245 250 255 Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu Tyr 260 265 270 Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val Arg 275 280 285 Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln Ser 290 295 300 Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys Leu 305 310 315 320 Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp 325 330 335 Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly 340 345 350 Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys 355 360 365 Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala 370 375 380 Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Gly Thr Asn Pro Asp 385 390 395 400 Ile Thr Gly Lys Val Pro Tyr Met Gly Glu Asp Gly Ile Val Arg Leu 405 410 415 Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu Ala 420 425 430 Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala Gln 435 440 445 Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu 450 455 460 Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys 465 470 475 480 Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr 485 490 495 Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg 500 505 510 Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe 515 520 525 Ser Val Lys Cys Ala Gly Met Pro Asp Arg Ile Lys Glu Leu Val Thr 530 535 540 Phe Asp Asn Phe Glu Val Gly Phe Ser Ser Tyr Gly Lys Leu Leu Pro 545 550 555 560 Lys Arg Thr Gln Gly Gly Val Val Leu Val Asp Thr Met Phe Thr Ile 565 570 575 Lys <210> 457 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 457 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Gln 290 295 300 Ser Leu Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Lys 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 458 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 458 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 459 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 459 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Arg 290 295 300 Ser Arg Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Asp Leu Phe Phe Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 460 <211> 573 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 460 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Gly Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Gly Tyr Ile Pro Thr Ile Gln Ile Lys Arg 290 295 300 Ser Arg Phe Tyr Lys Gly Asn Glu Tyr Leu Lys Ser Ser Gly Gly Glu 305 310 315 320 Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu Glu Leu Met Lys Glu 325 330 335 His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr Gly Tyr Met Phe Arg 340 345 350 Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp Lys Trp Thr Tyr Ile 355 360 365 Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu Ala Lys Leu Met Leu 370 375 380 Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro Asp Val Thr Gly Lys 385 390 395 400 Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly Phe Arg Leu Gly Glu 405 410 415 Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met Gly Val Phe Ile Thr 420 425 430 Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala Gln Ala Cys Tyr Asp 435 440 445 Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His Leu Thr Gly Thr Lys 450 455 460 Ile Pro Asp Val Ile Lys Asp Ile Val His Pro Lys Lys Leu Gly Tyr 465 470 475 480 Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys Tyr Leu Arg Gln Lys 485 490 495 Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val Arg Gly Tyr Leu Val 500 505 510 Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys Phe Ser Val Lys Cys 515 520 525 Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val Thr Phe Glu Asn Phe 530 535 540 Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys Pro Val Gln Val Pro 545 550 555 560 Gly Gly Val Val Leu Val Asp Ser Val Phe Thr Ile Lys 565 570 <210> 461 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 461 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 462 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 462 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser His Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 463 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 463 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 464 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 464 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Phe Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 465 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 465 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Val Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 466 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 466 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 467 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 467 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Ile Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Leu Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Glu Lys Ile Ala Lys Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Ile His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ala Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Met 420 425 430 Gly Val Phe Ile Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Ala Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Lys Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 468 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 468 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 469 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 469 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 470 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 470 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 471 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 471 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 472 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 472 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 473 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 473 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Leu Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 474 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 474 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 475 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 475 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ala Leu Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 476 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 476 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Arg 405 410 415 Leu Thr Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 477 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 477 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asp Gly Ile Val Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 478 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 478 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 479 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 479 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 480 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 480 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Val Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 481 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 481 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 482 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 482 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 483 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 483 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 484 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 484 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 485 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 485 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 486 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 486 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 487 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 487 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 488 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 488 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 489 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 489 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Val Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 490 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 490 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 491 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 491 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 492 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 492 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Gln Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Asn Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 493 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 493 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ala Leu Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 494 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 494 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 495 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 495 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Lys Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 496 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 496 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 497 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 497 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 498 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 498 Met Ser Arg Lys Arg Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Ala 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 499 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 499 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Leu Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Ile Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Leu Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Ile Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp His Pro Leu Tyr Ile Gln Asn Leu Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Cys Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Glu Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Glu Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Arg Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ile Val Gly 405 410 415 Phe Arg Val Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Arg Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Thr Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 500 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 500 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 405 410 415 Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 501 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 501 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Asp Asp Gly Ser Leu Gly 405 410 415 Phe Arg Val Gly Asp Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Thr Ile Lys Glu Glu Val 530 535 540 Thr Phe Asp Asn Phe Ala Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 502 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 502 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Val Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 503 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 503 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Lys Leu Thr Thr Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 504 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 504 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 505 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 505 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gln Arg Thr Ile Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 506 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 506 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Asn His Val Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 507 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 507 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Asn His Val Val Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 508 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 508 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Gly Thr Thr Gln Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 509 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 509 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Phe Arg Val Glu Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 510 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 510 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Phe Arg Val Glu Phe Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Arg Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 511 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 511 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Asp Lys Tyr Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 512 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 512 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Tyr Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 513 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 513 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Pro Lys Phe Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 514 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 514 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asn Pro Arg Tyr Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 515 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 515 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asp Pro Lys Tyr Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 516 <211> 578 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 516 Met Ser Arg Lys Met Phe Ser Cys Asp Phe Glu Thr Thr Thr Lys Leu 1 5 10 15 Asp Asp Cys Arg Val Trp Ala Tyr Gly Tyr Met Glu Ile Gly Asn Leu 20 25 30 Asp Asn Tyr Lys Ile Gly Asn Ser Leu Asp Glu Phe Met Gln Trp Val 35 40 45 Met Glu Ile Gln Ala Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly 50 55 60 Ala Phe Ile Val Asn Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys 65 70 75 80 Glu Ala Lys Glu Glu Arg Thr Phe Ser Thr Ile Ile Ser Arg Met Gly 85 90 95 Gln Trp Tyr Met Ile Asp Ile Cys Ile Gly Tyr Lys Gly Lys Arg Lys 100 105 110 Ile His Thr Val Ile Tyr Asp Ser Leu Lys Lys Leu Pro Phe Pro Val 115 120 125 Lys Lys Ile Ala Gln Asp Phe Lys Leu Thr Val Lys Lys Gly Asp Ile 130 135 140 Asp Tyr His Lys Glu Arg Pro Val Gly Tyr Lys Ile Thr Pro Glu Glu 145 150 155 160 Tyr Ala Tyr Ile Lys Asn Asp Ile Gln Ile Ile Ala Glu Ala Leu Leu 165 170 175 Ile Gln Phe Lys Gln Gly Leu Asp Arg Met Thr Ala Gly Ser Asp Ser 180 185 190 Leu Lys Asp Phe Lys Asp Ile Ile Thr Thr Lys Lys Phe Lys Lys Val 195 200 205 Phe Pro Thr Leu Ser Leu Gly Leu Asp Lys Glu Val Arg Lys Ala Tyr 210 215 220 Arg Gly Gly Phe Thr Trp Leu Asp Pro Arg Tyr Lys Gly Lys Glu Ile 225 230 235 240 Gly Glu Gly Met Val Phe Asp Ile Asn Ser Ala Tyr Pro Ala Gln Met 245 250 255 Tyr Val Arg Pro Leu Pro Tyr Gly Thr Pro Leu Phe Tyr Glu Gly Glu 260 265 270 Tyr Lys Glu Asn Ile Asp Tyr Pro Leu Tyr Ile Gln Asn Ile Lys Val 275 280 285 Arg Phe Arg Leu Lys Glu Arg His Ile Pro Thr Ile Gln Val Lys Gln 290 295 300 Ser Ser Leu Phe Ile Gln Asn Glu Tyr Leu Glu Ser Ser Val Asn Lys 305 310 315 320 Leu Gly Val Asp Glu Leu Ile Asp Leu Thr Leu Thr Asn Val Asp Leu 325 330 335 Asp Leu Phe Phe Glu His Tyr Asp Ile Leu Glu Ile His Tyr Thr Tyr 340 345 350 Gly Tyr Met Phe Lys Ala Ser Cys Asp Met Phe Lys Asp Phe Ile Asp 355 360 365 Lys Trp Thr Tyr Ile Lys Thr Thr Ser Tyr Gly Ala Ile Lys Gln Leu 370 375 380 Ala Lys Leu Met Leu Asn Ser Leu Tyr Gly Lys Phe Ala Ser Asn Pro 385 390 395 400 Asp Val Thr Gly Lys Val Pro Tyr Leu Lys Glu Asn Gly Ala Leu Gly 405 410 415 Phe Arg Leu Gly Glu Glu Glu Thr Lys Asp Pro Val Tyr Thr Pro Leu 420 425 430 Ala Ser Phe Val Thr Ala Trp Gly Arg Tyr Thr Thr Ile Thr Thr Ala 435 440 445 Gln Ala Cys Tyr Asp Arg Ile Ile Tyr Cys Asp Thr Asp Ser Ile His 450 455 460 Leu Thr Gly Thr Lys Ile Pro Asp Val Ile Lys Asp Ile Val His Pro 465 470 475 480 Lys Lys Leu Gly Tyr Trp Glu His Glu Ser Thr Phe Lys Arg Ala Lys 485 490 495 Tyr Leu Arg Gln Lys Thr Tyr Ile Gln Asp Ile Tyr Met Lys Arg Val 500 505 510 Arg Gly Tyr Leu Val Gln Gly Ser Pro Asp Asp Tyr Thr Asp Ile Lys 515 520 525 Phe Ser Val Lys Cys Ala Gly Met Thr Asp Lys Ile Lys Glu Glu Val 530 535 540 Thr Phe Glu Asn Phe Lys Val Gly Phe Ser Arg Lys Met Lys Pro Lys 545 550 555 560 Pro Val Gln Val Pro Gly Gly Val Val Leu Val Asp Ser Val Phe Thr 565 570 575 Ile Lys <210> 517 <211> 27 <212> PRT <213> Artificial sequence <220> <223> Synthetic polypeptide <400> 517 Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Leu Asn Asp 1 5 10 15 Phe Phe Glu Ala Gln Lys Ile Glu Trp His Glu 20 25 <210> 518 <211> 53 <212> PRT <213> Bacillus phage phi29 <400> 518 Asp Leu Tyr Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Ile Asn 1 5 10 15 Trp Leu Glu Arg Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn 20 25 30 Thr Tyr Asn Thr Ile Ile Ser Arg Met Gly Gln Trp Tyr Met Ile Asp 35 40 45 Ile Cys Leu Gly Tyr 50 <210> 519 <211> 53 <212> PRT <213> Bacteriophage M2Y <400> 519 Asp Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ala Phe Ile Val Asn 1 5 10 15 Trp Leu Glu Gln His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn 20 25 30 Thr Tyr Asn Thr Ile Ile Ser Lys Met Gly Gln Trp Tyr Met Ile Asp 35 40 45 Ile Cys Phe Gly Tyr 50 <210> 520 <211> 54 <212> PRT <213> Lucilia cuprina <400> 520 Arg Leu Tyr Phe His Asp Leu Lys Phe Asp Gly Ser Phe Ile Val Asn 1 5 10 15 Trp Leu Leu His Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu 20 25 30 Gly Gln Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Trp Tyr Gly Ile 35 40 45 Thr Ile Cys Ser Gly Arg 50 <210> 521 <211> 54 <212> PRT <213> Enterococcus faecium <400> 521 Asp Ile Tyr Phe His Asp Glu Lys Phe Asp Gly Glu Phe Met Leu Ser 1 5 10 15 Trp Leu Phe Lys Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu 20 25 30 Arg Thr Phe Ser Thr Leu Ile Ser Asn Met Gly Gln Trp Tyr Ala Leu 35 40 45 Glu Ile Cys Trp Asn Val 50 <210> 522 <211> 56 <212> PRT <213> Bacillus phage GA-1 <400> 522 Asp Ile Tyr Phe His Asn Leu Lys Phe Asp Gly Ser Phe Ile Leu Pro 1 5 10 15 Trp Trp Leu Arg Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn 20 25 30 Thr Pro Lys Glu Phe Thr Thr Thr Ile Ser Gly Met Gly Gln Trp Tyr 35 40 45 Ala Val Asp Val Cys Ile Asn Thr 50 55 <210> 523 <211> 53 <212> PRT <213> Bacillus phage VMY22 <400> 523 Asp Leu Tyr Phe His Asp Leu Arg Tyr Asp Gly Glu Phe Ile Val Asn 1 5 10 15 Trp Leu Leu His Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys 20 25 30 Thr Phe Asp Thr Val Ile Ser Lys Gly Gly Gln Trp Tyr Lys Ile Ala 35 40 45 Ile His His Glu Gly 50 <210> 524 <211> 54 <212> PRT <213> Actinomyces phage AV-1 <400> 524 His Ile Tyr Phe His Asn Leu Ala Phe Asp Gly Thr Phe Ile Leu Asp 1 5 10 15 Trp Leu Leu Lys His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val 20 25 30 Lys Glu Phe Thr Ser Leu Ile Ser Arg Met Gly Lys Tyr Tyr Ser Ile 35 40 45 Thr Val Val Phe Glu Thr 50 <210> 525 <211> 55 <212> PRT <213> Globodera sp. <400> 525 Ile Thr Phe Phe His Asn Leu Lys Phe Asp Gly Ala Phe Ile Leu Asp 1 5 10 15 Arg Leu Phe Arg Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln 20 25 30 Val Lys Glu Phe Ser Thr Leu Ile Ser Lys Met Gly Gln Phe Tyr Ser 35 40 45 Ile Lys Val Arg Trp Glu Asn 50 55 <210> 526 <211> 56 <212> PRT <213> Lynx pardinus <400> 526 Arg Val Tyr Phe His Asn Leu Lys Phe Asp Gly Lys Phe Ile Leu His 1 5 10 15 Lys Ile Leu Thr Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys 20 25 30 Ala Asn Arg Thr Phe Thr Thr Leu Ile Ser Asp Met Ser Gln Phe Tyr 35 40 45 Ser Ile Lys Leu Trp Phe Asp Glu 50 55 <210> 527 <211> 55 <212> PRT <213> Candidatus Moranbacteria <400> 527 Glu Val Phe Phe His Asn Leu Lys Tyr Asp Gly Asp Phe Ile Val Lys 1 5 10 15 Phe Leu Leu Glu Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr 20 25 30 Ser Asn Glu Phe Ser Thr Leu Ile Ser Asp Thr Gly Thr Trp Tyr Glu 35 40 45 Ile Lys Ile Cys Phe His Ala 50 55 <210> 528 <211> 57 <212> PRT <213> Eggerthella sp. <400> 528 Leu Ile Gly Phe His Asn Leu Lys Phe Asp Gly Ser Tyr Ile Leu Ser 1 5 10 15 Tyr Leu Leu Gly Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala 20 25 30 Arg Lys Ala Lys Thr Val Glu Cys Leu Ile Ser Ser Ile Gly Val His 35 40 45 Tyr Asn Tyr Arg Ile Asn Phe Thr Lys 50 55 <210> 529 <211> 12 <212> PRT <213> Bacillus phage phi29 <400> 529 Asn Gly Phe Lys Trp Ser Ala Asp Gly Leu Pro Asn 1 5 10 <210> 530 <211> 12 <212> PRT <213> Bacteriophage M2Y <400> 530 His Gly Phe Lys Trp Ser Asn Glu Gly Leu Pro Asn 1 5 10 <210> 531 <211> 13 <212> PRT <213> Lucilia cuprina <400> 531 Asn Gly Tyr Thr Trp Thr Lys Arg Pro Ser Lys Glu Gly 1 5 10 <210> 532 <211> 13 <212> PRT <213> Enterococcus faecium <400> 532 Asn Gly Phe Lys Trp Cys Lys Glu Ala Lys Glu Glu Arg 1 5 10 <210> 533 <211> 15 <212> PRT <213> Bacillus phage GA-1 <400> 533 Asn Gly Tyr Val His Thr Glu Glu Asp Arg Thr Asn Thr Pro Lys 1 5 10 15 <210> 534 <211> 12 <212> PRT <213> Bacillus phage VMY22 <400> 534 Lys Gly Tyr Glu Cys Asn Glu Ser Gly Arg Pro Lys 1 5 10 <210> 535 <211> 13 <212> PRT <213> Actinomyces phage AV-1 <400> 535 His Gly Tyr Arg Trp Thr Lys Glu Asn Pro Gly Val Lys 1 5 10 <210> 536 <211> 14 <212> PRT <213> Globodera sp. <400> 536 Leu Gly Tyr Glu Phe Thr Asp Glu Lys Ala Pro Gln Val Lys 1 5 10 <210> 537 <211> 15 <212> PRT <213> Lynx pardinus <400> 537 Asp Gly Trp Lys Trp Ile Pro Asp Lys Asn Asp Cys Ala Asn Arg 1 5 10 15 <210> 538 <211> 14 <212> PRT <213> Eggerthella sp. <400> 538 Asn Gly Phe Lys His Ser Arg Glu Arg Ala Leu Tyr Ser Asn 1 5 10 <210> 539 <211> 16 <212> PRT <213> Eggerthella sp. <400> 539 Val Ala Lys Trp Glu Tyr Asn Asp Lys Pro Lys Ala Arg Lys Ala Lys 1 5 10 15

Claims (1)

  1. 표 1로부터 선택된 제1 중합 효소에 기초한 재조합 중합 효소이며, 여기서 제1 중합 효소의 적어도 하나의 아미노산 절편이 표 1로부터 선택된 제2 중합 효소로부터의 상응하는 아미노산 절편으로 대체되었고, 제1 중합 효소와 제2 중합 효소가 상이하고, 임의로 재조합 중합 효소가 표 1의 제1 및/또는 제2 중합 효소의 서열과 비교하여 하나 이상의 아미노산 삽입, 결실, 또는 치환을 추가로 포함하는 것인 재조합 중합 효소.
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230052995A (ko) 2016-12-19 2023-04-20 퀀텀-에스아이 인코포레이티드 시퀀싱 반응을 위한 중합 효소
JP7167024B2 (ja) 2016-12-19 2022-11-08 クアンタム－エスアイ インコーポレイテッド 分析するための分子の試料ウェル中へのローディング
MX2019013111A (es) 2017-05-05 2019-12-16 Quantum Si Inc Sustratos que tienen reactividad de superficie modificada y propiedades antiincrustantes en reacciones biologicas.
ES2983417T3 (es) 2018-01-29 2024-10-23 St Jude Childrens Res Hospital Inc Método para la amplificación de ácidos nucleicos
US10934533B1 (en) 2018-10-10 2021-03-02 New England Biolabs, Inc. Variant DNA polymerases having improved properties and method for improved isothermal amplification of a target DNA
US10865441B2 (en) * 2019-03-13 2020-12-15 Abclonal Science, Inc. Mutant Taq polymerase for faster amplification
WO2020234200A1 (en) * 2019-05-17 2020-11-26 4basebio Sl Phi29 dna polymerase mutants with improved primer recognition
JP2022539560A (ja) * 2019-06-28 2022-09-12 クアンタム－エスアイ インコーポレイテッド 配列決定反応のための重合酵素
EP4028570A1 (en) 2019-10-11 2022-07-20 Quantum-Si Incorporated Surface modification in the vapor phase
AU2021219665A1 (en) * 2020-02-10 2022-09-01 BioSkryb Genomics, Inc. Phi29 mutants and use thereof
AU2021401791A1 (en) 2020-12-15 2023-07-06 Quantum-Si Incorporated Molecular barcode analysis by single-molecule kinetics
CN116083393B (zh) * 2023-02-14 2025-09-23 南方科技大学 一种dna装配分子机器及其应用
WO2025067248A1 (zh) * 2023-09-25 2025-04-03 成都今是科技有限公司 用于单分子测序的核酸聚合酶及其突变株
CN119082075B (zh) * 2024-09-12 2025-06-27 湖南艾科瑞生物工程有限公司 性能提升的phi29 DNA聚合酶突变体及其制备方法与应用

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4435728A1 (de) 1994-01-19 1995-07-20 Boehringer Mannheim Gmbh Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
US5654419A (en) 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
GB2333597B (en) 1996-10-29 2001-04-18 Univ Nebraska At Lincoln Method for detecting point mutations in dna utilizing fluorescence energy transfer
DE19810879A1 (de) 1998-03-13 1999-09-16 Roche Diagnostics Gmbh Polymerasenchimären
US6153442A (en) 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
WO2000036151A1 (en) 1998-12-14 2000-06-22 Li-Cor, Inc. A heterogeneous assay for pyrophosphate detection
US6914128B1 (en) 1999-03-25 2005-07-05 Abbott Gmbh & Co. Kg Human antibodies that bind human IL-12 and methods for producing
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
DK2322631T3 (en) 2001-04-19 2015-01-12 Scripps Research Inst Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
US20100035254A1 (en) 2003-04-08 2010-02-11 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
US7745116B2 (en) 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
GB0324456D0 (en) 2003-10-20 2003-11-19 Isis Innovation Parallel DNA sequencing methods
EP1725572B1 (de) 2003-11-05 2017-05-31 AGCT GmbH Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
WO2007070572A2 (en) 2005-12-12 2007-06-21 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Probe for nucleic acid sequencing and methods of use
AU2006330947B2 (en) * 2005-12-22 2012-04-12 Pacific Biosciences Of California, Inc. Polymerases for nucleotide analogue incorporation
US8084734B2 (en) 2006-05-26 2011-12-27 The George Washington University Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays
WO2009097368A2 (en) 2008-01-28 2009-08-06 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
EP2263087B1 (en) 2008-03-13 2017-08-09 Pacific Biosciences of California, Inc. Labeled reactants and their uses
EP3045542B1 (en) 2008-03-28 2016-11-16 Pacific Biosciences of California, Inc. Methods for nucleic acid sequencing
EP2286217B1 (en) 2008-03-31 2015-02-18 Pacific Biosciences of California, Inc. Single molecule loading methods and compositions
CA2720046C (en) 2008-03-31 2018-07-24 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8420366B2 (en) 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
US9127259B2 (en) * 2008-03-31 2015-09-08 Pacific Biosciences Of California, Inc. Enzymes resistant to photodamage
ES2571446T3 (es) 2008-11-03 2016-05-25 Kapa Biosystems Inc ADN polimerasas quiméricas
US8252910B2 (en) 2008-11-19 2012-08-28 Pacific Biosciences Of California, Inc. Modular nucleotide compositions and uses therefor
WO2010065322A1 (en) 2008-12-01 2010-06-10 Research Triangle Institute Concurrent identification of multitudes of polypeptides
KR101063981B1 (ko) 2009-01-12 2011-09-14 서강대학교산학협력단 자유 라디칼 개시제 및 이를 이용한 펩타이드 서열의 동정방법
DE102009013653B4 (de) 2009-03-18 2014-09-18 Bruker Daltonik Gmbh Protein-Sequenzierung mit MALDI-Massenspektrometrie
US20100255487A1 (en) 2009-03-27 2010-10-07 Life Technologies Corporation Methods and apparatus for single molecule sequencing using energy transfer detection
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
EP3964586A1 (en) 2009-04-03 2022-03-09 Sequenom, Inc. Nucleic acid preparation compositions and methods
ES2359058B1 (es) * 2009-07-02 2012-03-27 Consejo Superior De Investigaciones Cient�?Ficas (Csic) Quimera de adn polimerasa del fago ph1 29.
US9566335B1 (en) 2009-09-25 2017-02-14 The Governing Council Of The University Of Toronto Protein sequencing method and reagents
WO2011040971A2 (en) * 2009-09-30 2011-04-07 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
JP2013527769A (ja) 2010-05-06 2013-07-04 アイビス バイオサイエンシズ インコーポレイティッド 統合された試料調製システムおよび安定化酵素混合物
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US8906660B2 (en) * 2012-02-01 2014-12-09 Pacific Biosciences Of California, Inc. Recombinant polymerases with increased phototolerance
US9062091B2 (en) 2012-02-15 2015-06-23 Pacific Biosciences Of California, Inc. Polymerase enzyme substrates with protein shield
US9399766B2 (en) * 2012-10-01 2016-07-26 Pacific Biosciences Of California, Inc. Recombinant polymerases for incorporation of protein shield nucleotide analogs
US9435810B2 (en) 2013-03-15 2016-09-06 Washington University Molecules and methods for iterative polypeptide analysis and processing
CN105308073B (zh) 2013-06-14 2019-08-13 加利福尼亚太平洋生物科学股份有限公司 双生物素化标签
US10544449B2 (en) 2013-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Bis-biotinylation tags
WO2015021079A1 (en) 2013-08-05 2015-02-12 Pacific Biosciences Of California, Inc. Protected fluorescent reagent compounds
CA2961493C (en) 2014-09-15 2023-10-03 Board Of Regents, The University Of Texas System Improved single molecule peptide sequencing
EP3204511B1 (en) 2014-10-07 2021-07-28 Oxford Nanopore Technologies Limited Mutant pores
WO2016126941A1 (en) 2015-02-04 2016-08-11 Pacific Biosciences Of California, Inc. Multimeric protected fluorescent reagents
EP3371194B1 (en) 2015-10-16 2020-12-30 Andrew Emili Protein sequencing method
US10814299B2 (en) 2015-11-18 2020-10-27 Pacific Biosciences Of California, Inc. Loading nucleic acids onto substrates
US10676788B2 (en) 2015-11-20 2020-06-09 Pacific Biosciences Of California, Inc. Modified nucleotide reagents
KR20230052995A (ko) * 2016-12-19 2023-04-20 퀀텀-에스아이 인코포레이티드 시퀀싱 반응을 위한 중합 효소
WO2019040825A1 (en) 2017-08-24 2019-02-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services CONFORMATIONAL RESTRICTION OF CYANINE FLUOROPHORES IN A FAR RED RANGE AND CLOSE INFRARED
US10836798B2 (en) 2018-11-08 2020-11-17 Government Of The United States Of America, As Represented By The Secretary Of Commerce Amino acid-specific binder and selectively identifying an amino acid
JP2022539560A (ja) * 2019-06-28 2022-09-12 クアンタム－エスアイ インコーポレイテッド 配列決定反応のための重合酵素

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