KR840002402A - 1-옥사데티아-세펨유도체의 제조법 - Google Patents

1-옥사데티아-세펨유도체의 제조법 Download PDF

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KR840002402A
KR840002402A KR1019820005346A KR820005346A KR840002402A KR 840002402 A KR840002402 A KR 840002402A KR 1019820005346 A KR1019820005346 A KR 1019820005346A KR 820005346 A KR820005346 A KR 820005346A KR 840002402 A KR840002402 A KR 840002402A
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group
formula
general formula
derivative
compound
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KR880002089B1 (ko
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세이지(외5) 시바하라
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나카가와타케시
메이지제과 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음.

Description

1-옥사데티아-세펨유도체의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 다음 일반식(II)의 디아조합물을 카르벤도입축매와 반응시켜 폐환(ring-cloeed)시킴을 특징으로 하는 다음 일반식(III)의 1-옥사 데티아-세펨유도체의 제조법.
    위 식에서 A는 아실기, R1은 수소 또는 메톡시기, R2는 카르복시보호기이다.
  2. 다음 일반식(II)의 디아조화합물을 카르벤도입축매와 반응시켜 폐환시킴으로써 다음 일반식(III)의 1-옥사-1-데피아-3-히드록시세팔로스포린유도체를 생성하여 일반식(III)의 유도체의 3위 히드록시기를 알킬화제(alkylation reagent)와 반응시킴을 특징으로 하는 일반식(I)의 1-옥사데티아세펨유도체의 제조법.
  3. 제1항 또는 제2항에 있어서, 일반식(II)의 화합물에서 아실기 A는 식 R4CO-(R4는 아릴기, 특히 페닐기임)의 아로일기, 또는 R6CO-(R6는 아랄킬기, 특히 벤질기 또는 페녹시메틸기임)의 아실기임을 특징으로 하는 일반식(I)의 1-옥사데티아-세펨유도체의 제조법.
  4. 제1항 또는 제2항에 있어서, 카르벤도입축매는 일반식(II) 화합물에서 디아조기(N2)가 결합되는 있는 탄소원자를 카르벤으로 전화할 수 있는 물질, 특히 모듐 아세테이프, 로듐옥시드 또는 산화은임을 특징으로 하는 일반식(I)의 1-옥사데리아-세펨유도체의 제조법.
  5. 다음 일반식(II)로 표시되는 새로운 유용한 디아조화합물을 출발화합물로서 사용함을 특징으로 하는 1-옥사데티아-세펨유도체의 제조법.
    위 식에서 A는 아실기 R1은 수소원자 또는 메톡시기, R2는 카르복시보호기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8205346A 1981-12-11 1982-11-27 1-옥사데티아-세펨유도체의 제조방법 Expired KR880002089B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP198466 1981-12-11
JP56-198466 1981-12-11
JP56198466A JPS58103391A (ja) 1981-12-11 1981-12-11 １−オキサデチア−セフエム誘導体の製造法

Publications (2)

Publication Number Publication Date
KR840002402A true KR840002402A (ko) 1984-07-02
KR880002089B1 KR880002089B1 (ko) 1988-10-15

Family

ID=16391570

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8205346A Expired KR880002089B1 (ko) 1981-12-11 1982-11-27 1-옥사데티아-세펨유도체의 제조방법

Country Status (5)

Country Link
EP (1) EP0081824B1 (ko)
JP (1) JPS58103391A (ko)
KR (1) KR880002089B1 (ko)
DE (1) DE3267837D1 (ko)
PH (1) PH20594A (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936684A (ja) * 1982-08-24 1984-02-28 Shionogi & Co Ltd １−オキサセフアム化合物の製造方法
EP0133670A3 (de) * 1983-08-09 1985-12-18 Bayer Ag Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592245A (en) * 1976-08-09 1981-07-01 Shionogi & Co Intermediates for cephalosporin analogues
US4174316A (en) * 1978-08-14 1979-11-13 Merck & Co., Inc. 4-Iodomethylazetidin-2-one

Also Published As

Publication number Publication date
EP0081824B1 (en) 1985-12-04
JPS58103391A (ja) 1983-06-20
PH20594A (en) 1987-02-24
DE3267837D1 (en) 1986-01-16
EP0081824A1 (en) 1983-06-22
JPH0222757B2 (ko) 1990-05-21
KR880002089B1 (ko) 1988-10-15

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