KR860000278A - Method for preparing tetrahydro-β-carboline derivative - Google Patents

Method for preparing tetrahydro-β-carboline derivative Download PDF

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Publication number
KR860000278A
KR860000278A KR1019850003845A KR850003845A KR860000278A KR 860000278 A KR860000278 A KR 860000278A KR 1019850003845 A KR1019850003845 A KR 1019850003845A KR 850003845 A KR850003845 A KR 850003845A KR 860000278 A KR860000278 A KR 860000278A
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KR
South Korea
Prior art keywords
formula
compound
lower alkyl
hydrogen
carboxy
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Abandoned
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KR1019850003845A
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Korean (ko)
Inventor
이꾸오 이이지마 (외 4)
Original Assignee
마쓰바라 이찌로
다나베 세이야꾸 가부시끼 가이샤
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Application filed by 마쓰바라 이찌로, 다나베 세이야꾸 가부시끼 가이샤 filed Critical 마쓰바라 이찌로
Publication of KR860000278A publication Critical patent/KR860000278A/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음No content

Description

테르라히드로-β-카르볼린 유도체의 제조방법Method for preparing terahydro-β-carboline derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (1)

a)다음식(Ⅰ)의 화합물(Ⅰ)을 얻기위헤 다음식(Ⅱ)의 화합물을 반응시키거나; 또는 b) 다음식(Ⅰ-d)의 화합물을 얻기위해 다음식(Ⅳ)의 화합물과 디아조-저급알칸; 저급알카노산 또는 그의 반응성 유도체; 및 불포화된 산소-함유 모노시클릭헤테로고리 화합물로 구성되는 기로부터 선택된 화합물을 반응시키고; 및 c) 필요하다면, 그의 염으로 전환시킴을 특징으로하는 다음식(Ⅰ)의 화합물의 제조방법a) reacting the compound of formula (II) to obtain compound (I) of formula (I); Or b) a compound of formula (IV) and a diazo-lower alkane to obtain a compound of formula (I-d); Lower alkanoic acid or reactive derivatives thereof; And a compound selected from the group consisting of unsaturated oxygen-containing monocyclic heterocyclic compounds; And c) a process for the preparation of a compound of formula (I) characterized by conversion to salts thereof, if necessary (Ⅰ) (Ⅰ) 상기 식에서 R2는 저급알킬이고, 및 A) R1늠 히드록시메틸 또는 카르복시이고,R3및 R4는 모두 수소이고, X는 할로겐, 저급알킬, 저급알콕시, 히드록시 또는 벤질옥시이거나, 또는 B) R1은 수소, 카르복시-저급알킬 또는 식; -CH2OY(식중, Y는 저급알킬, 저급알카노일 또는 산소함유 모노시클릭헤테로고리기임)의 기이고, R3는 수소, 히드록시-저급알킬 또는 카르복시이고, R4는 수소 또는 히드록시-저급알킬이고 및 X는 수소이다.Wherein R 2 is lower alkyl, and A) R 1 is hydroxymethyl or carboxy, R 3 and R 4 are both hydrogen, X is halogen, lower alkyl, lower alkoxy, hydroxy or benzyloxy, or B) R 1 is hydrogen, carboxy-loweralkyl or a formula; -CH 2 OY, wherein Y is a lower alkyl, lower alkanoyl or oxygen-containing monocyclic heterocyclic group, R 3 is hydrogen, hydroxy-lower alkyl or carboxy, and R 4 is hydrogen or hydroxy Lower alkyl and X is hydrogen. (Ⅱ) (Ⅱ) 상기 식에서 R1,R3,R4및 X는 상기에 정의한 바와 같다.Wherein R 1 , R 3 , R 4 and X are as defined above. R2-X1(Ⅲ)R 2 -X 1 (III) 상기 식에서 X1은 할로겐이고, R2는 상기에 정의한 바와 같다.Wherein X 1 is halogen and R 2 is as defined above. (Ⅳ) (Ⅳ) 상기 식에서 R2는 상기에 정의한 바와 같다.Wherein R 2 is as defined above. (Ⅰ-d) (I-d) 상기 식에서 Y눈 저급알킬, 저급알카노일 또는 산소함유모노시클릭 헤테로고리기이다.Y is lower alkyl, lower alkanoyl or oxygen-containing monocyclic heterocyclic group. ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019850003845A 1984-06-06 1985-06-01 Method for preparing tetrahydro-β-carboline derivative Abandoned KR860000278A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB84/14409 1984-06-06
GB848414409A GB8414409D0 (en) 1984-06-06 1984-06-06 Tetrahydro-beta-carboline derivative

Publications (1)

Publication Number Publication Date
KR860000278A true KR860000278A (en) 1986-01-27

Family

ID=10562001

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850003845A Abandoned KR860000278A (en) 1984-06-06 1985-06-01 Method for preparing tetrahydro-β-carboline derivative

Country Status (3)

Country Link
KR (1) KR860000278A (en)
CN (1) CN85104455A (en)
GB (1) GB8414409D0 (en)

Also Published As

Publication number Publication date
GB8414409D0 (en) 1984-07-11
CN85104455A (en) 1986-12-10

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