KR890000497A - 아실 유도체 - Google Patents
아실 유도체 Download PDFInfo
- Publication number
- KR890000497A KR890000497A KR1019880007211A KR880007211A KR890000497A KR 890000497 A KR890000497 A KR 890000497A KR 1019880007211 A KR1019880007211 A KR 1019880007211A KR 880007211 A KR880007211 A KR 880007211A KR 890000497 A KR890000497 A KR 890000497A
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- compound
- group
- carboxylic acid
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000002252 acyl group Chemical group 0.000 title claims 14
- 150000001875 compounds Chemical class 0.000 claims 49
- -1 cyano, nitro, amino, mercapto Chemical group 0.000 claims 43
- 125000000217 alkyl group Chemical group 0.000 claims 37
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 37
- 229910052739 hydrogen Inorganic materials 0.000 claims 23
- 239000001257 hydrogen Substances 0.000 claims 23
- 150000003839 salts Chemical class 0.000 claims 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 20
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 18
- 125000004432 carbon atom Chemical group C* 0.000 claims 14
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 150000002431 hydrogen Chemical class 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 150000002148 esters Chemical class 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 6
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 6
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 6
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 239000001301 oxygen Substances 0.000 claims 6
- 125000004434 sulfur atom Chemical group 0.000 claims 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 125000004442 acylamino group Chemical group 0.000 claims 5
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 5
- 208000035473 Communicable disease Diseases 0.000 claims 4
- 239000012467 final product Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000005276 alkyl hydrazino group Chemical group 0.000 claims 2
- 125000004414 alkyl thio group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006244 carboxylic acid protecting group Chemical group 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 2
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 2
- SCNWTQPZTZMXBG-UHFFFAOYSA-N 2-methyloct-2-enoic acid Chemical compound CCCCCC=C(C)C(O)=O SCNWTQPZTZMXBG-UHFFFAOYSA-N 0.000 claims 1
- WIEHERIZUJMBMS-UHFFFAOYSA-N C12SCC=C(C(O)=O)N2C(=O)C1(OC)NC(=O)CC1=CC=CS1 Chemical compound C12SCC=C(C(O)=O)N2C(=O)C1(OC)NC(=O)CC1=CC=CS1 WIEHERIZUJMBMS-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6292887A | 1987-06-16 | 1987-06-16 | |
| US062,928 | 1987-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR890000497A true KR890000497A (ko) | 1989-03-15 |
Family
ID=22045776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880007211A Withdrawn KR890000497A (ko) | 1987-06-16 | 1988-06-16 | 아실 유도체 |
Country Status (13)
| Country | Link |
|---|---|
| KR (1) | KR890000497A (fr) |
| AU (1) | AU1769288A (fr) |
| CS (1) | CS271490B2 (fr) |
| DK (1) | DK323788A (fr) |
| FI (1) | FI882885A7 (fr) |
| HU (1) | HUT47120A (fr) |
| IL (1) | IL86719A0 (fr) |
| MC (1) | MC1952A1 (fr) |
| NO (1) | NO882652L (fr) |
| NZ (1) | NZ224997A (fr) |
| PT (1) | PT87733B (fr) |
| YU (1) | YU116788A (fr) |
| ZA (1) | ZA884093B (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA877987B (en) * | 1986-11-12 | 1988-08-31 | Ici Pharma | Antibiotic compounds |
| FR2621589B1 (fr) * | 1987-10-08 | 1990-03-02 | Sanofi Sa | Derives des cephalosporines a pharmacocinetique amelioree, procede pour leur preparation et compositions pharmaceutiques les contenant |
| GB8811056D0 (en) * | 1988-05-10 | 1988-06-15 | Ici Plc | Antibiotic compounds |
-
1988
- 1988-06-08 ZA ZA884093A patent/ZA884093B/xx unknown
- 1988-06-13 NZ NZ224997A patent/NZ224997A/xx unknown
- 1988-06-13 IL IL86719A patent/IL86719A0/xx unknown
- 1988-06-13 HU HU883025A patent/HUT47120A/hu unknown
- 1988-06-14 DK DK323788A patent/DK323788A/da unknown
- 1988-06-14 MC MC881985A patent/MC1952A1/fr unknown
- 1988-06-15 AU AU17692/88A patent/AU1769288A/en not_active Abandoned
- 1988-06-15 NO NO882652A patent/NO882652L/no unknown
- 1988-06-15 PT PT87733A patent/PT87733B/pt not_active IP Right Cessation
- 1988-06-15 CS CS884158A patent/CS271490B2/cs unknown
- 1988-06-16 YU YU01167/88A patent/YU116788A/xx unknown
- 1988-06-16 FI FI882885A patent/FI882885A7/fi not_active IP Right Cessation
- 1988-06-16 KR KR1019880007211A patent/KR890000497A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| FI882885A0 (fi) | 1988-06-16 |
| PT87733B (pt) | 1992-10-30 |
| CS271490B2 (en) | 1990-10-12 |
| AU1769288A (en) | 1988-12-22 |
| HUT47120A (en) | 1989-01-30 |
| DK323788D0 (da) | 1988-06-14 |
| PT87733A (pt) | 1988-07-01 |
| CS415888A2 (en) | 1990-02-12 |
| MC1952A1 (fr) | 1989-06-30 |
| DK323788A (da) | 1988-12-17 |
| NZ224997A (en) | 1991-02-26 |
| NO882652D0 (no) | 1988-06-15 |
| FI882885A7 (fi) | 1988-12-17 |
| ZA884093B (en) | 1989-04-26 |
| YU116788A (en) | 1990-04-30 |
| IL86719A0 (en) | 1988-11-30 |
| NO882652L (no) | 1988-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19880616 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |