KR920008024A - 퀴놀린 유도체 - Google Patents

퀴놀린 유도체 Download PDF

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KR920008024A
KR920008024A KR1019910018237A KR910018237A KR920008024A KR 920008024 A KR920008024 A KR 920008024A KR 1019910018237 A KR1019910018237 A KR 1019910018237A KR 910018237 A KR910018237 A KR 910018237A KR 920008024 A KR920008024 A KR 920008024A
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hydrogen atom
halogen atom
alkyl group
alkoxy
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KR100206200B1 (ko
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히로시 하세가와
카주오 이소마에
다케시 고쯔가이
노리아끼 시오이리
구미꼬 세키네
나오가따 타이도
스스무 사또
다다유끼 구라이시
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다이또 나오가따
에스에스 세이야꾸 가부시끼가이샤
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Publication of KR920008024A publication Critical patent/KR920008024A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

퀴놀린 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식( I )로 표시되는 퀴놀린 유도체 또는 그의 염.
    상기식에서〉A-는〉N-(CH2)n-, 〉C=, 〉C=CH(CH2)n-, 또는 〉CH(CH2)n-기를 나타내며(여기서, n은 1-7의 정수임.), Y는 〉C=O 또는 〉CHOH기를 나타내고, R1은 수소원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이며, R2는 수소원자, 할로겐, 알킬기, 히드록시기, 알콕시기, 치환기를 가질수 있는 페닐기, 페놀시기, 알카노일옥시기 또는 치환기를 가져도 좋은 아미노기이며, R3는 수소원자, 할로겐원자, 알킬기, 또는 알콕시기이며, m은 1-3의 정수다.
  2. 하기 일반식( I )의 퀴놀린 유도체 또는 그의 염과 약학적으로 허용되는 담체로 구성된 아세틸콜린에스테라제 저해 조성물.
    상기식에서〉A-는〉N-(CH2)n-, 〉C=, 〉C=CH(CH2)n-, 또는 〉CH(CH2)n-기를 나타내며(여기서, n은 1-7의 정수임.), Y는 〉C=O 또는 〉CHOH기를 나타내고, R1은 수소원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이며, R2는 수소원자, 할로겐원자, 알킬기, 히드록시기, 알콕시기, 치환기를 가질수 있는 페닐기, 페놀시기, 알카노일옥시기 또는 치환기를 가져도 좋은 아미노기이며, R3는 수소원자, 할로겐원자, 알킬기, 또는 알콕시기이며, m은 1-3의 정수다.
  3. 하기 일반식( I )의 퀴놀린 유도체 또는 그의 염의 유효량을 치매 또는 치매의 위험으로 고통받는 사람에게 투여하는 것을 특징으로 하는 치매의 예방 및 치료방법.
    상기식에서〉A-는〉N-(CH2)n-, 〉C=, 〉C=CH(CH2)n-, 또는 〉CH(CH2)n-기를 나타내며(여기서, n은 1-7의 정수임.), Y는 〉C=O 또는 〉CHOH기를 나타내고, R1은 수소원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이며, R2는 수소원자, 할로원자, 알킬기, 히드록시기, 알콕시기, 치환기를 가질수 있는 페닐기, 페놀시기, 알카노일옥시기 또는 치환기를 가져도 좋은 아미노기이며, R3는 수소원자, 할로겐원자, 알킬기, 또는 알콕시기이며, m은 1-3의 정수다.
  4. 하기 일반식(Ⅱ)로 표시되는 피페리딘 유도체 또는 그의 염.
    상기 식에서 R1은 수소 원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이고, R3은 수소원자, 할로겐원자, 알킬기 또는 알콕시기이고 n은 0-7의 정수이며, 점선은 단일 결합 또는 이중결합이 임의로 존재함을 나타낸다.
  5. 하기 일반식(Ⅱ)의 피페리딘 유도체 또는 그의 염과 약학적으로 허용되는 담체로 구성된 아세틸콜린에스테라제 저해 조성물.
    상기 식에서 R1은 수소 원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이고, R3은 수소원자, 할로겐원자, 알킬기 또는 알콕시기이고 n은 0-7의 정수이며, 점선은 단일 결합 또는 이중결합이 임의로 존재함을 나타낸다.
  6. 하기 일반식( I )의 피페리딘 유도체 또는 그의 염의 유효량을 치매 또는 치매의 위험으로 고통받는 사람에게 투여하는 것을 특징으로 하는 치매의 예방 및 치료방법.
    상기 식에서 R1은 수소 원자, 할로겐 원자, 알킬기, 알콕시기 또는 알킬티오기이고, R3은 수소원자, 할로겐원자, 알킬기 또는 알콕시기이고 n은 0-7의 정수이며, 점선은 단일 결합 또는 이중결합이 임의로 존재함을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910018237A 1990-10-19 1991-10-16 퀴놀린유도체 Expired - Fee Related KR100206200B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP90-281094 1990-10-19
JP28109390 1990-10-19
JP28109490 1990-10-19
JP90-281093 1990-10-19

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KR920008024A true KR920008024A (ko) 1992-05-27
KR100206200B1 KR100206200B1 (ko) 1999-07-01

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US (2) US5190951A (ko)
EP (2) EP0987262A1 (ko)
KR (1) KR100206200B1 (ko)
CA (1) CA2053640C (ko)
DE (1) DE69132519T2 (ko)
ES (1) ES2156853T3 (ko)
SG (1) SG44523A1 (ko)

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CN102875602B (zh) * 2012-10-25 2015-05-20 江苏神龙药业有限公司 一种米诺膦酸水合物的制备方法
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
NZ760341A (en) 2013-12-20 2021-12-24 Agenebio Inc Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
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US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
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CN112601749B (zh) 2018-06-19 2024-03-26 艾吉因生物股份有限公司 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法
CN112608326B (zh) * 2021-01-22 2021-10-01 河南大学 呋喃并[2,3-b]喹啉-3,4（2H,9H)-二酮衍生物、其制备方法及应用
CN114989180B (zh) * 2022-05-26 2024-06-04 广东海洋大学 杨叶肖槿内生真菌来源的化合物及其制备方法与应用
CN120584115A (zh) 2022-08-19 2025-09-02 艾吉因生物股份有限公司 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法

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NZ216720A (en) * 1985-07-08 1990-09-26 Bristol Myers Co Diazinylpiperidine derivatives and pharmaceutical compositions
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Publication number Publication date
EP0481429B1 (en) 2001-01-24
EP0481429A2 (en) 1992-04-22
EP0481429A3 (en) 1992-08-19
CA2053640C (en) 2001-12-25
US5300517A (en) 1994-04-05
US5190951A (en) 1993-03-02
ES2156853T3 (es) 2001-08-01
SG44523A1 (en) 1997-12-19
EP0987262A1 (en) 2000-03-22
KR100206200B1 (ko) 1999-07-01
DE69132519D1 (de) 2001-03-01
HK1011351A1 (en) 1999-07-09
DE69132519T2 (de) 2001-06-13
CA2053640A1 (en) 1992-04-20

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