KR920700213A - 인지질 유도체 - Google Patents

인지질 유도체

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Publication number
KR920700213A
KR920700213A KR1019900702335A KR900702335A KR920700213A KR 920700213 A KR920700213 A KR 920700213A KR 1019900702335 A KR1019900702335 A KR 1019900702335A KR 900702335 A KR900702335 A KR 900702335A KR 920700213 A KR920700213 A KR 920700213A
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KR
South Korea
Prior art keywords
formula
represent
same
group
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
KR1019900702335A
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English (en)
Other versions
KR0148362B1 (ko
Inventor
가즈미 오가따
교오조 야마모또
다까히로 마쓰모또
Original Assignee
요시다 소우지
센쥬 세이야꾸 가부시끼가이샤
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Application filed by 요시다 소우지, 센쥬 세이야꾸 가부시끼가이샤 filed Critical 요시다 소우지
Publication of KR920700213A publication Critical patent/KR920700213A/ko
Application granted granted Critical
Publication of KR0148362B1 publication Critical patent/KR0148362B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

내용 없음

Description

인지질 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기식으로서 표시되는 인지질 유도체.
    또는
    〔상기식중, R1및 R2는 서로 동일 또는 상이한 알킬기 또는 아실기를 나타내는데, 단 각식은 입체 배위를 나타내는 것은 아니다.〕
  2. 제1항에 있어서, R1또는 R2가 C1∼C18의 알킬기 또는 아실기인 인지질 유도체.
  3. 하기식
    〔식중, R1및 R2는 서로 동일 또는 상이한 알킬기 또는 아실기이고; X는 할로겐을 나타내는데, 단 각식은 입체 배위를 나타내는 것은 아니다〕로서 표시되는 글리세린 할로 인산 에스테르를 5, 6위치가 보호된 아스코르빈산과 반응시킨 다음, 보호기를 이탈시키는 것을 특징으로 하는 하기식
    〔식중 R1및 R2는 상기 정의와 동일하다. 상기의 각 식은 입체 배위를 나타내는 것은 아니다.〕로서 표시되는 인지질 유도체.
  4. 제3항에 있어서, 글리세린 할로 인산 에스테르 유도체가 글리세린의 3개의 수산기 중 임의의 2개의 수산기의 수소가 각각 R1및 R2〔단, R1및 R2는 상기 정의와 동일하다〕로 치환된 화합물에 할로인 에스테르화제를 탈산제의 존재하에 작용시키는 제조법.
  5. 제3항에 있어서, 5, 6 위치가 보호된 아스코르빈산의 보호기가 이소프로필리덴기이며, 보호기를 염산 또는 황산으로 이탈시키는 제조법.
  6. 하기식
    또는
    〔식중, R1및 R2는 서로 동일 또는 상이한 알킬기 또는 아실기를 나타내는데, 단 각식은 입체 배위를 나타내는 것은 아니다〕로서 표시되는 인지질 유도체로서된 항산화제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900702335A 1989-04-27 1990-04-24 인지질 유도체 Expired - Fee Related KR0148362B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10999289 1989-04-27
JP109992/89 1989-04-27
PCT/JP1990/000534 WO1990012800A1 (en) 1989-04-27 1990-04-24 Phospholipid derivatives

Publications (2)

Publication Number Publication Date
KR920700213A true KR920700213A (ko) 1992-02-19
KR0148362B1 KR0148362B1 (ko) 1999-02-01

Family

ID=14524340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900702335A Expired - Fee Related KR0148362B1 (ko) 1989-04-27 1990-04-24 인지질 유도체

Country Status (12)

Country Link
US (1) US5098898A (ko)
EP (1) EP0423366B1 (ko)
JP (1) JP2782117B2 (ko)
KR (1) KR0148362B1 (ko)
AT (1) ATE118500T1 (ko)
CA (1) CA2031505C (ko)
DE (1) DE69016914T2 (ko)
DK (1) DK0423366T3 (ko)
ES (1) ES2067739T3 (ko)
RU (1) RU2002753C1 (ko)
UA (1) UA19385A1 (ko)
WO (1) WO1990012800A1 (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA19385A1 (uk) * 1989-04-27 1997-12-25 Сендзю Фармасьютікал Ко. Лтд. Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
FR2690343B1 (fr) * 1992-04-28 1995-09-01 Inocosm Laboratoires Composition anti-radicalaire et anti-lipoperoxydante.
TW252918B (ko) * 1993-03-31 1995-08-01 Senju Pharma Co
EP0843554B1 (en) * 1996-05-14 1999-12-08 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
JP2007070239A (ja) * 2005-09-05 2007-03-22 Toyo Beauty Kk 乳化組成物
JP5111822B2 (ja) * 2006-10-11 2013-01-09 東洋ビューティ株式会社 コラーゲン産生促進剤および抗老化化粧料

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4815605B1 (ko) * 1969-05-16 1973-05-16
JPS59219295A (ja) * 1983-05-30 1984-12-10 Senjiyu Seiyaku Kk リン酸ジエステルまたはその塩およびそれらの製造法
US4647672A (en) * 1985-06-25 1987-03-03 Kansas State University Research Foundation Ascorbate 2-polyphosphate esters and method of making same
US4939128A (en) * 1988-04-25 1990-07-03 Takeda Chemical Industries, Ltd. Ester of ascorbic acid 2-phosphate and pharmaceutical use
UA19385A1 (uk) * 1989-04-27 1997-12-25 Сендзю Фармасьютікал Ко. Лтд. Фофоліпідhі похідhі та композиція, яка має аhтиоксидаhтhу та іhгібуючу активhість щодо пероксидів ліпідів
US5013850A (en) * 1990-03-30 1991-05-07 Allergan, Inc. 4-ethyl and 4-ethenyl-5-hydroxy-2(5H)-furanones substituted on alpha carbon of the ethyl or ethenyl side chain with a long chain alkyl group and on the beta carbon with a polar group, as anti-inflammatory agents

Also Published As

Publication number Publication date
ATE118500T1 (de) 1995-03-15
EP0423366A4 (en) 1991-09-11
US5098898A (en) 1992-03-24
DK0423366T3 (da) 1995-06-19
JP2782117B2 (ja) 1998-07-30
KR0148362B1 (ko) 1999-02-01
CA2031505C (en) 1999-03-23
EP0423366A1 (en) 1991-04-24
DE69016914D1 (de) 1995-03-23
ES2067739T3 (es) 1995-04-01
RU2002753C1 (ru) 1993-11-15
UA19385A1 (uk) 1997-12-25
WO1990012800A1 (en) 1990-11-01
CA2031505A1 (en) 1990-10-28
DE69016914T2 (de) 1995-06-08
EP0423366B1 (en) 1995-02-15

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