KR970061902A - (3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 용도 - Google Patents

(3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 용도 Download PDF

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KR970061902A
KR970061902A KR1019970004335A KR19970004335A KR970061902A KR 970061902 A KR970061902 A KR 970061902A KR 1019970004335 A KR1019970004335 A KR 1019970004335A KR 19970004335 A KR19970004335 A KR 19970004335A KR 970061902 A KR970061902 A KR 970061902A
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South Korea
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alkyl
alkoxyphenyl
magnesium
chloride
magnesium chloride
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KR1019970004335A
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KR100521062B1 (ko
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미하엘 핀캄
토마스 코넨
베르너 빈터
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비르츠 프란츠, 파우쓰-베르구스
그뤼넨탈 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B49/00—Grignard reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

본 발명은 (3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 특정의 카보닐 화합물과의 반응을 위한 이의 용도에 관한 것이다.

Description

(3-알콕시페닐)마그네슘 클로라이드의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)콜로라이드를, 마그네슘 할라이드를 알칼리 금속으로 환원시켜 수득된 활성 마그네슘과 반응시킴으로써 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)마그네슘 클로라이드를 제조하는 방법.
  2. 제1항에 있어서, 활성 마그네슘이 염화마그네슘을 리튬, 나트륨 또는 칼륨으로 환원시킴으로써 수득됨을 특징으로 하는 방법.
  3. 제1항 또는 제2항에 있어서, 알콕시 라디칼이 메톡시, 에톡시, 프로폭시, 이소프로폭시, n-부톡시 또는 사이클로펜톡시인 (3-알콕시페닐)클로라이드를 활성 마그네슘과 반응시킴을 특징으로 하는 방법.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, (3-메톡시페닐)클로라이드 또는 (3-에콕시페닐)클로라이드를 활성 마그네슘과 반응시킴을 특징으로 하는 방법.
  5. 화학식(1)의 β-아미노알데히드 또는 β-아미노케톤 또는 화학식(2)의 알데히드 또는 케톤과의 반응을 위한, 알콕시 라디칼 중의 탄소수가 1 내지 5인 (3-알콕시페닐)마그네슘 클로라이드의 용도.
    상기 식에서, R1은 H 또는 C1-4알킬이고, R2는 H 또는 C1-4알킬이거나, R1과 함께하는 R2는 -(CH2)4-이거나, R3과 함께하는 R2는 C4-7사이클로알킬이거나, R4와 함께 R2는 C5-8사이클로알킬이거나, R5와 함께 R2는 5 내지 8원헤테로사이클이고, R3은 H 또는 직쇄 C1-4알킬이고, R4는 H이고, R5는 C1-3알킬이고, R|6은 C1-3알킬이고, R7과 R8은 동일하거나 상이하고 각각 H, C1-6알킬 또는 C3-6사이클로알킬이다.
  6. 제5항에 있어서, (3-알콕시페닐)마그네슘 클로라이드가 β-아미노알데히드 또는 β-아미노케톤과의 반응에 사용됨을 특징으로 하는 용도.
  7. 제5항 또는 제6항에 있어서, (3-알콕시페닐)마그네슘 클로라이드가, R1이 C1-4알킬이고, R2가 H 또는 C1-4알킬이거나, R1과 함께하는 R2가 -(CH2)4-이고 R3이 H 또는 직쇄 C1-4알킬이고, R4가 H이고, R5는 CH3이고 R6이 CH3인 화학식(1)의 β-아미노알데히드 또는 β-아미노케톤과의 반응에 사용됨을 특징으로 하는 용도.
  8. 제5항 내지 제7항 중 어느 한 항에 있어서, 알콕시 라디칼이 메톡시, 에톡시, 프로톡시, 이소프로톡시, n-부톡시 또는 사이클로펜톡시인 (3-알콕시페닐)마그네슘 클로라이드가 사용됨을 특징으로 하는 용도.
  9. 제5항 내지 제8항 중 어느 한 항에 있어서, (3-메톡시페닐)마그네슘 클로라이드 또는 (3-에톡시페닐)마그네슘 클로라이드가 사용됨을 특징으로 하는 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970004335A 1996-02-16 1997-02-14 (3-알콕시페닐)마그네슘클로라이드의제조방법및당해클로라이드를사용한알콜제조방법 Expired - Fee Related KR100521062B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19605778A DE19605778C1 (de) 1996-02-16 1996-02-16 Herstellung und Verwendung von (3-Alkoxyphenyl)magnesiumchloriden
DE19605778.7 1996-02-16

Related Child Applications (1)

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KR1020050032652A Division KR100541786B1 (ko) 1996-02-16 2005-04-20 (3-알콕시페닐)마그네슘 클로라이드를 사용한 알콜의 제조방법

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KR970061902A true KR970061902A (ko) 1997-09-12
KR100521062B1 KR100521062B1 (ko) 2006-01-12

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KR1019970004335A Expired - Fee Related KR100521062B1 (ko) 1996-02-16 1997-02-14 (3-알콕시페닐)마그네슘클로라이드의제조방법및당해클로라이드를사용한알콜제조방법
KR1020050032652A Expired - Fee Related KR100541786B1 (ko) 1996-02-16 2005-04-20 (3-알콕시페닐)마그네슘 클로라이드를 사용한 알콜의 제조방법

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Country Link
US (1) US5852216A (ko)
EP (1) EP0790251B1 (ko)
JP (1) JP3893180B2 (ko)
KR (2) KR100521062B1 (ko)
CN (1) CN1075075C (ko)
AR (1) AR005775A1 (ko)
AT (1) ATE229025T1 (ko)
AU (1) AU707621B2 (ko)
BR (1) BR9700208A (ko)
CA (1) CA2197616C (ko)
CO (1) CO4770991A1 (ko)
CZ (1) CZ290270B6 (ko)
DE (2) DE19605778C1 (ko)
DK (1) DK0790251T3 (ko)
ES (1) ES2187690T3 (ko)
HU (1) HU219060B (ko)
IL (1) IL120224A (ko)
IN (1) IN192277B (ko)
MY (1) MY113636A (ko)
NO (1) NO315943B1 (ko)
NZ (1) NZ299965A (ko)
PE (1) PE1098A1 (ko)
PL (1) PL185309B1 (ko)
PT (1) PT790251E (ko)
RU (1) RU2177931C2 (ko)
SI (1) SI0790251T1 (ko)
SK (1) SK282190B6 (ko)
UA (1) UA46740C2 (ko)
UY (1) UY24460A1 (ko)
ZA (1) ZA971232B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19757499A1 (de) * 1997-12-23 1999-06-24 Studiengesellschaft Kohle Mbh Verfahren zur Synthese von Organomagnesium-Verbindungen unter Einsatz von Katalysatoren
US6531597B2 (en) * 2001-02-13 2003-03-11 Hoffmann-La Roche Inc. Process for preparation of 2-phenyl acetic acid derivatives
RU2345057C2 (ru) * 2003-10-13 2009-01-27 Митени, С.П.А. Способ получения 3,5-бис(трифторметил)бензилового спирта
EP1785412A1 (en) * 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
US9882245B2 (en) 2013-08-23 2018-01-30 Ut-Battelle, Llc Alkoxide-based magnesium electrolyte compositions for magnesium batteries

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2959596A (en) 1957-11-22 1960-11-08 Metal & Thermit Corp Aryl chloride-cyclic ether grignard reagents
US3706809A (en) * 1970-09-17 1972-12-19 Takasago Perfumery Co Ltd Process for preparing highly reactive organo-magnesium compounds
US4133824A (en) * 1977-08-17 1979-01-09 Texas Alkyls, Inc. Organo-magnesium complexes and process for their preparation
JPS5818323A (ja) * 1981-07-27 1983-02-02 Sumitomo Chem Co Ltd アルコ−ル類の製造方法
JPS6072833A (ja) * 1983-09-29 1985-04-24 Hokko Chem Ind Co Ltd 芳香族ビニル化合物の改良製造法
US4731203A (en) * 1983-11-09 1988-03-15 Studiengesellschaft Kohle Mbh Process for using finely divided highly reactive magnesium
CA1284665C (en) * 1984-07-26 1991-06-04 Eric George Delmar Process for hydroxymethylation
US5273686A (en) * 1987-07-11 1993-12-28 Studiengesellschaft Kohle Mbh Soluble magnesium hydrides, method of preparing them, and use thereof
EP0307106B1 (en) 1987-09-11 1992-01-15 Hokko Chemical Industry Co., Ltd P- or m-tert butoxyphenethyl alcohol and process for preparing the same
JP3107920B2 (ja) 1992-08-28 2000-11-13 花王株式会社 歯磨剤の製造方法
US5358670A (en) * 1993-07-02 1994-10-25 Ferro Corporation Process for preparing grignard reagents in diethylene glycol dibutyl ether

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HU9700441D0 (en) 1997-04-28
AR005775A1 (es) 1999-07-14
EP0790251B1 (de) 2002-12-04
NZ299965A (en) 1998-01-26
KR100541786B1 (ko) 2006-01-11
US5852216A (en) 1998-12-22
PL185309B1 (pl) 2003-04-30
CZ43097A3 (en) 1997-09-17
CZ290270B6 (cs) 2002-06-12
HUP9700441A2 (en) 1997-10-28
KR100521062B1 (ko) 2006-01-12
PT790251E (pt) 2003-04-30
CO4770991A1 (es) 1999-04-30
HUP9700441A3 (en) 2000-03-28
IL120224A (en) 2002-05-23
IL120224A0 (en) 1997-06-10
DE19605778C1 (de) 1997-04-17
BR9700208A (pt) 1998-10-27
EP0790251A2 (de) 1997-08-20
EP0790251A3 (de) 1999-09-22
SK282190B6 (sk) 2001-12-03
UY24460A1 (es) 1997-04-14
ES2187690T3 (es) 2003-06-16
RU2177931C2 (ru) 2002-01-10
HU219060B (hu) 2001-02-28
PL318486A1 (en) 1997-08-18
UA46740C2 (uk) 2002-06-17
NO970698L (no) 1997-08-18
HK1004812A1 (en) 1998-12-11
ATE229025T1 (de) 2002-12-15
SK20297A3 (en) 1997-09-10
MY113636A (en) 2002-04-30
AU1471597A (en) 1997-08-21
SI0790251T1 (en) 2003-06-30
PE1098A1 (es) 1998-02-21
CA2197616A1 (en) 1997-08-17
ZA971232B (en) 1997-08-25
CN1075075C (zh) 2001-11-21
JPH09227575A (ja) 1997-09-02
AU707621B2 (en) 1999-07-15
IN192277B (ko) 2004-03-27
NO315943B1 (no) 2003-11-17
CA2197616C (en) 2005-08-16
DE59708849D1 (de) 2003-01-16
DK0790251T3 (da) 2003-03-17
JP3893180B2 (ja) 2007-03-14
NO970698D0 (no) 1997-02-14
CN1166491A (zh) 1997-12-03

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