LT2229351T - Didelio grynumo laipsnio 2-[4-(3- arba 2-fluorbenziloksi)benzilamino]propanamidų gamybos būdas - Google Patents

Didelio grynumo laipsnio 2-[4-(3- arba 2-fluorbenziloksi)benzilamino]propanamidų gamybos būdas

Info

Publication number: LT2229351T
Authority: LT; Lithuania
Prior art keywords: propanamides; fluorobenzyloxy; benzylamino; production; high purity
Prior art date: 2007-12-11

Application number

LTEP08860373.3T

Other languages

English (en)

Inventor

Elena Barbanti

Laura Faravelli

Patricia Salvati

Renato Canevotti

Francesco Ponzini

Original Assignee

Newron Pharmaceuticals S.P.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-11

Filing date

2008-12-01

Publication date

2018-01-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39301684&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2229351(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-12-01 Application filed by Newron Pharmaceuticals S.P.A. filed Critical Newron Pharmaceuticals S.P.A.

2018-01-25 Publication of LT2229351T publication Critical patent/LT2229351T/lt

Links

-1 2-fluorobenzyloxy Chemical group 0.000 title 1
125000000440 benzylamino group Chemical group [H]N(*)C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

LTEP08860373.3T 2007-12-11 2008-12-01 Didelio grynumo laipsnio 2-[4-(3- arba 2-fluorbenziloksi)benzilamino]propanamidų gamybos būdas LT2229351T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07023937		2007-12-11
PCT/EP2008/066559 WO2009074478A1 (en)	2007-12-11	2008-12-01	Process for the production of 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides with high purity degree

Publications (1)

Publication Number	Publication Date
LT2229351T true LT2229351T (lt)	2018-01-25

Family

ID=39301684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP08860373.3T LT2229351T (lt)	2007-12-11	2008-12-01	Didelio grynumo laipsnio 2-[4-(3- arba 2-fluorbenziloksi)benzilamino]propanamidų gamybos būdas

Country Status (25)

Country	Link
US (2)	US8530701B2 (lt)
EP (2)	EP2229351B1 (lt)
JP (2)	JP5460613B2 (lt)
KR (2)	KR101593627B1 (lt)
CN (2)	CN104523668B (lt)
AR (1)	AR071267A1 (lt)
AU (1)	AU2008334778B2 (lt)
CA (2)	CA2936209C (lt)
CY (1)	CY1119991T1 (lt)
DK (1)	DK2229351T3 (lt)
EA (2)	EA030250B1 (lt)
ES (2)	ES2837000T3 (lt)
HR (1)	HRP20180210T1 (lt)
HU (1)	HUE036232T2 (lt)
IL (1)	IL205872A (lt)
LT (1)	LT2229351T (lt)
MX (1)	MX2010006278A (lt)
NO (1)	NO2229351T3 (lt)
NZ (1)	NZ585806A (lt)
PL (1)	PL2229351T3 (lt)
PT (1)	PT2229351T (lt)
RS (1)	RS56803B1 (lt)
SI (1)	SI2229351T1 (lt)
TW (1)	TWI429425B (lt)
WO (1)	WO2009074478A1 (lt)

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ES2339021T3 (es) *	2003-08-25	2010-05-14	Newron Pharmaceuticals S.P.A.	Derivados de alfa-aminoamida utiles como agentes antiinflamatorios.
DK2474521T3 (en)	2006-06-19	2016-10-31	Newron Pharm Spa	High-purity 2- [4- (3- and 2-fluorobenzyloxy) benzylamino] propanamides for use as pharmaceuticals and pharmaceutical formulations thus
KR101593627B1 (ko) *	2007-12-11	2016-02-11	뉴론 파마슈티칼즈 에스. 피. 에이.	고순도의 ２［４（３ 또는 ２플루오로벤질옥시）벤질아미노］프로판아미드의 제조방법
EP2314569A1 (en)	2009-10-22	2011-04-27	Merck Patent GmbH	Novel polymorphic forms of (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide mesylate salt and processes of manufacturing thereof
NZ602648A (en) *	2010-04-27	2014-10-31	Newron Pharm Spa	Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers
CN103201260B (zh)	2010-11-11	2015-05-27	莱德克斯制药有限公司	药物衍生物
CN103044279B (zh) *	2012-12-21	2015-07-08	苏州永健生物医药有限公司	一种n-香豆酰多巴胺的合成方法
WO2015102390A1 (ko) *	2013-12-30	2015-07-09	이화여자대학교 산학협력단	신규한 아미드 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 통증의 예방 또는 치료용 약학적 조성물
CN104292128A (zh) *	2014-07-01	2015-01-21	南京正科制药有限公司	一种沙芬酰胺晶型a
CN105017060B (zh) *	2015-07-03	2017-06-16	南京正大天晴制药有限公司	一种沙芬酰胺新晶型及其制备方法
CN106365966A (zh) *	2015-07-24	2017-02-01	上海医药集团股份有限公司	一种苄基芳基醚的制备方法
CN105061245A (zh) *	2015-08-25	2015-11-18	成都维恒医药科技有限公司	一种高纯度沙芬酰胺的制备方法
CN106565521B (zh) *	2016-08-24	2019-03-08	浙江美诺华药物化学有限公司	(s)-2-[3-(3-氟苄基)-4-(3-氟苄氧基)苄氨基]丙酰胺及其盐的制备方法
CN106565442B (zh) *	2016-08-24	2019-07-16	浙江美诺华药物化学有限公司	3-(3-氟苄基)-4-(3-氟苄氧基)苯甲醛的制备方法
CN106632223B (zh) *	2016-08-24	2019-04-23	浙江美诺华药物化学有限公司	2-(3-溴-4-(3-氟苄氧基)苯基)-1,3-二氧戊环及其制备方法
CN106596828B (zh) *	2016-12-15	2018-09-25	扬子江药业集团有限公司	一种甲磺酸沙芬酰胺有关物质的检测方法
WO2019167085A1 (en) *	2018-03-01	2019-09-06	Msn Laboratories Private Limited, R&D Center	Process for the preparation of (s)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino propanamide methanesulfonate
WO2020136671A1 (en) *	2018-12-27	2020-07-02	Natco Pharma Limited	Improved process for the preparation of lapatinib base and it's anhydrous ditosylate salt
EP3725768A1 (en) *	2019-04-17	2020-10-21	Newron Pharmaceuticals S.p.A.	Process for the production of substituted 2-[2-(phenyl) ethylamino]alkaneamide derivatives
US11111208B2 (en)	2019-06-17	2021-09-07	RK Pharma Solutions LLC	Process for the preparation of safinamide mesylate intermediate
ES2977486T3 (es)	2019-08-06	2024-08-26	Medichem Sa	Proceso para preparar safinamida
CN113444010B (zh) *	2020-03-28	2023-09-05	南京正大天晴制药有限公司	一种沙芬酰胺有关物质的制备方法
CN112028754A (zh) *	2020-06-17	2020-12-04	浙江美诺华药物化学有限公司	一种甲磺酸沙芬酰胺中间体的制备方法
CN114088830B (zh) *	2021-11-10	2022-09-23	石家庄四药有限公司	一种4-(3-氟苄氧基)苯甲醛中异构体的检测方法

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GB9727523D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Alpha-aminoamide derivatives useful as analgesic agents
NZ521870A (en)	2000-03-31	2004-08-27	Euro Celtique S	Aminopyridines and their use as anticonvulsants and sodium channel blockers
SI1423168T1 (sl)	2001-09-03	2006-06-30	Newron Pharm Spa	Farmacevtski sestavek, ki vsebuje gabapentin ali njegov analog in alfa-aminoamid, in njegova analgetska uporaba
EP1438956A1 (en) *	2003-01-16	2004-07-21	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives useful as antimigraine agents
JP2006515326A (ja) *	2003-01-30	2006-05-25	ダイノジェンファーマシューティカルズ，インコーポレイテッド	胃腸管障害を処置するためのナトリウムチャネルモジュレーターの使用
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TW200507850A (en)	2003-07-25	2005-03-01	Kyowa Hakko Kogyo Kk	Pharmaceutical composition
ES2339021T3 (es)	2003-08-25	2010-05-14	Newron Pharmaceuticals S.P.A.	Derivados de alfa-aminoamida utiles como agentes antiinflamatorios.
EP1557166A1 (en)	2004-01-21	2005-07-27	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) *	2004-04-22	2005-10-26	Newron Pharmaceuticals S.p.A.	Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
US20080096965A1 (en) *	2004-09-10	2008-04-24	Newron Pharmaceuticals S.P.A.	(Halobenzyloxy) Benzylamino-Propanamides as Sodium and/or Calcium Channel Selective Modulators
DK2474521T3 (en) *	2006-06-19	2016-10-31	Newron Pharm Spa	High-purity 2- [4- (3- and 2-fluorobenzyloxy) benzylamino] propanamides for use as pharmaceuticals and pharmaceutical formulations thus
KR101593627B1 (ko) *	2007-12-11	2016-02-11	뉴론 파마슈티칼즈 에스. 피. 에이.	고순도의 ２［４（３ 또는 ２플루오로벤질옥시）벤질아미노］프로판아미드의 제조방법

2008
- 2008-12-01 KR KR1020107015305A patent/KR101593627B1/ko active Active
- 2008-12-01 CN CN201410639898.7A patent/CN104523668B/zh active Active
- 2008-12-01 DK DK08860373.3T patent/DK2229351T3/en active
- 2008-12-01 CA CA2936209A patent/CA2936209C/en active Active
- 2008-12-01 LT LTEP08860373.3T patent/LT2229351T/lt unknown
- 2008-12-01 EA EA201400105A patent/EA030250B1/ru unknown
- 2008-12-01 ES ES17181175T patent/ES2837000T3/es active Active
- 2008-12-01 KR KR1020167002929A patent/KR101709498B1/ko active Active
- 2008-12-01 EA EA201070719A patent/EA019898B1/ru unknown
- 2008-12-01 EP EP08860373.3A patent/EP2229351B1/en active Active
- 2008-12-01 US US12/747,008 patent/US8530701B2/en active Active
- 2008-12-01 HR HRP20180210TT patent/HRP20180210T1/hr unknown
- 2008-12-01 JP JP2010537377A patent/JP5460613B2/ja active Active
- 2008-12-01 RS RS20180078A patent/RS56803B1/sr unknown
- 2008-12-01 ES ES08860373.3T patent/ES2655706T3/es active Active
- 2008-12-01 MX MX2010006278A patent/MX2010006278A/es active IP Right Grant
- 2008-12-01 SI SI200831910T patent/SI2229351T1/en unknown
- 2008-12-01 WO PCT/EP2008/066559 patent/WO2009074478A1/en not_active Ceased
- 2008-12-01 PT PT88603733T patent/PT2229351T/pt unknown
- 2008-12-01 HU HUE08860373A patent/HUE036232T2/hu unknown
- 2008-12-01 AU AU2008334778A patent/AU2008334778B2/en active Active
- 2008-12-01 CN CN200880120328.XA patent/CN101896456B/zh active Active
- 2008-12-01 CA CA2706789A patent/CA2706789C/en active Active
- 2008-12-01 NO NO08860373A patent/NO2229351T3/no unknown
- 2008-12-01 NZ NZ585806A patent/NZ585806A/en unknown
- 2008-12-01 EP EP17181175.5A patent/EP3257842B1/en active Active
- 2008-12-01 PL PL08860373T patent/PL2229351T3/pl unknown
- 2008-12-09 TW TW097147775A patent/TWI429425B/zh active
- 2008-12-11 AR ARP080105372A patent/AR071267A1/es active IP Right Grant
2010
- 2010-05-20 IL IL205872A patent/IL205872A/en active IP Right Grant
2013
- 2013-08-07 US US13/961,693 patent/US8846763B2/en active Active
2014
- 2014-01-10 JP JP2014002958A patent/JP6023727B2/ja active Active
2018
- 2018-01-03 CY CY20181100007T patent/CY1119991T1/el unknown

Also Published As

Publication number	Publication date
HK1204960A1 (en)	2015-12-11
EP3257842B1 (en)	2020-11-18
US20100324141A1 (en)	2010-12-23
CA2936209A1 (en)	2009-06-18
CA2706789C (en)	2016-09-06
US8530701B2 (en)	2013-09-10
EP3257842A1 (en)	2017-12-20
AU2008334778B2 (en)	2013-05-23
KR20160017140A (ko)	2016-02-15
TW200932209A (en)	2009-08-01
RS56803B1 (sr)	2018-04-30
ES2655706T3 (es)	2018-02-21
NZ585806A (en)	2011-09-30
KR101709498B1 (ko)	2017-02-23
DK2229351T3 (en)	2018-01-22
CN101896456B (zh)	2014-10-22
SI2229351T1 (en)	2018-02-28
EA201400105A1 (ru)	2014-05-30
HRP20180210T1 (hr)	2018-03-09
NO2229351T3 (lt)	2018-04-07
JP2014159407A (ja)	2014-09-04
PT2229351T (pt)	2018-01-19
EA030250B1 (ru)	2018-07-31
PL2229351T3 (pl)	2018-04-30
AR071267A1 (es)	2010-06-09
CA2936209C (en)	2020-02-11
HUE036232T2 (hu)	2018-06-28
CY1119991T1 (el)	2018-12-12
US20140051758A1 (en)	2014-02-20
HK1145673A1 (en)	2011-04-29
KR101593627B1 (ko)	2016-02-11
EP2229351B1 (en)	2017-11-08
TWI429425B (zh)	2014-03-11
KR20100103571A (ko)	2010-09-27
AU2008334778A1 (en)	2009-06-18
JP2011506375A (ja)	2011-03-03
JP6023727B2 (ja)	2016-11-09
BRPI0820657A2 (pt)	2015-06-16
US8846763B2 (en)	2014-09-30
EA201070719A1 (ru)	2010-12-30
EP2229351A1 (en)	2010-09-22
WO2009074478A1 (en)	2009-06-18
EA019898B1 (ru)	2014-07-30
CA2706789A1 (en)	2009-06-18
IL205872A0 (en)	2010-11-30
JP5460613B2 (ja)	2014-04-02
AU2008334778A2 (en)	2010-07-08
MX2010006278A (es)	2010-08-31
CN104523668B (zh)	2020-06-09
CN101896456A (zh)	2010-11-24
ES2837000T3 (es)	2021-06-29
IL205872A (en)	2015-06-30
CN104523668A (zh)	2015-04-22

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