LT2643313T - Chinazolino karboksamido azetidinai - Google Patents

Chinazolino karboksamido azetidinai

Info

Publication number: LT2643313T
Authority: LT; Lithuania
Prior art keywords: azetidines; quinazoline carboxamide; quinazoline; carboxamide; carboxamide azetidines
Prior art date: 2010-11-24

Application number

LTEP11785338.2T

Other languages

English (en)

Inventor

Bayard R. Huck

Reinaldo Jones

Yufang Xiao

Constantin Neagu

Donald Bankston

Andreas Goutopoulos

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-11-24

Filing date

2011-11-11

Publication date

2016-10-25

2011-11-11 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2016-10-25 Publication of LT2643313T publication Critical patent/LT2643313T/lt

Links

WTEATYPQEYDEKP-UHFFFAOYSA-N azetidine;quinazoline-2-carboxamide Chemical class C1CNC1.C1=CC=CC2=NC(C(=O)N)=NC=C21 WTEATYPQEYDEKP-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Reproductive Health (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

LTEP11785338.2T 2010-11-24 2011-11-11 Chinazolino karboksamido azetidinai LT2643313T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US41713110P	2010-11-24	2010-11-24
PCT/EP2011/005691 WO2012069146A1 (en)	2010-11-24	2011-11-11	Quinazoline carboxamide azetidines

Publications (1)

Publication Number	Publication Date
LT2643313T true LT2643313T (lt)	2016-10-25

Family

ID=45001695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP11785338.2T LT2643313T (lt)	2010-11-24	2011-11-11	Chinazolino karboksamido azetidinai

Country Status (30)

Country	Link
US (1)	US8946247B2 (lt)
EP (1)	EP2643313B9 (lt)
JP (1)	JP5897590B2 (lt)
KR (1)	KR101894116B1 (lt)
CN (1)	CN103228649B (lt)
AR (1)	AR093725A1 (lt)
AU (1)	AU2011334173B2 (lt)
BR (1)	BR112013012488B1 (lt)
CA (1)	CA2818706C (lt)
CL (1)	CL2013001459A1 (lt)
CO (1)	CO6721019A2 (lt)
DK (1)	DK2643313T3 (lt)
EA (1)	EA023821B1 (lt)
ES (1)	ES2594404T3 (lt)
HR (1)	HRP20161183T1 (lt)
HU (1)	HUE028967T2 (lt)
IL (1)	IL226233A (lt)
LT (1)	LT2643313T (lt)
MX (1)	MX355325B (lt)
MY (1)	MY186456A (lt)
NZ (1)	NZ612224A (lt)
PE (1)	PE20140966A1 (lt)
PL (1)	PL2643313T3 (lt)
PT (1)	PT2643313T (lt)
RS (1)	RS55204B1 (lt)
SG (1)	SG190318A1 (lt)
SI (1)	SI2643313T1 (lt)
UA (1)	UA112167C2 (lt)
WO (1)	WO2012069146A1 (lt)
ZA (1)	ZA201304637B (lt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI2755965T1 (sl)	2011-09-12	2017-12-29	Merck Patent Gmbh	Novi imidazolni amidi kot modulatorji kinazne aktivnosti
SG2014009260A (en)	2011-09-12	2014-09-26	Merck Patent Gmbh	Aminopyrimidine derivatives for use as modulators of kinase activity
JP6386467B2 (ja)	2012-11-16	2018-09-05	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	キナーゼ活性のモジュレーターとしての新規複素環式誘導体
ES2807539T3 (es)	2012-11-16	2021-02-23	Merck Patent Gmbh	Derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
WO2014085528A1 (en) *	2012-11-29	2014-06-05	Merck Patent Gmbh	Azaquinazoline carboxamide derivatives
SG11201505999VA (en)	2013-03-11	2015-08-28	Merck Patent Gmbh	6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
AU2015240094B2 (en)	2014-04-03	2020-07-30	Merck Patent Gmbh	Combinations of cancer therapeutics
CA2970394C (en) *	2014-12-11	2023-03-14	Merck Patent Gmbh	Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with a quinazoline derivative
WO2017140803A1 (en) *	2016-02-16	2017-08-24	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Modulators of tumor immune resistance for the treatment of cancer
US20190054110A1 (en) *	2016-02-16	2019-02-21	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	Modulators of ccr9 for treating tumor resistance to immune responses
WO2019170543A1 (en)	2018-03-07	2019-09-12	Bayer Aktiengesellschaft	Identification and use of erk5 inhibitors
WO2021094209A1 (en)	2019-11-12	2021-05-20	Bayer Aktiengesellschaft	Substituted pyrrolo triazine carboxamide derivatives as prostaglandin ep3 receptor antagonists
JP2023551408A (ja) *	2020-11-16	2023-12-08	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	がん処置のためのキナーゼインヒビター組み合わせ
CN116490187A (zh) *	2020-11-16	2023-07-25	默克专利股份公司	用于癌症治疗的激酶抑制剂组合
US11866421B2 (en) *	2021-05-31	2024-01-09	Epigen Biosciences, Inc.	Pyrimidine and pyridine amine compounds and usage thereof in disease treatment
CA3262155A1 (en)	2022-08-11	2024-02-15	Evexta Bio	COMPOUNDS FOR CANCER TREATMENT
WO2025168601A1 (en)	2024-02-05	2025-08-14	Evexta Bio	Quinazoline carboxamide azetidine compounds for use in treating hormone dependent diseases

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200306819A (en)	2002-01-25	2003-12-01	Vertex Pharma	Indazole compounds useful as protein kinase inhibitors
JPWO2004014873A1 (ja) *	2002-08-09	2005-12-02	杏林製薬株式会社	４−置換キナゾリン−８−カルボン酸アミド誘導体とその薬理上許容される付加塩
US7135575B2 (en) *	2003-03-03	2006-11-14	Array Biopharma, Inc.	P38 inhibitors and methods of use thereof
WO2004092154A1 (en)	2003-04-03	2004-10-28	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of protein kinases
CN100412066C (zh)	2003-09-30	2008-08-20	Irm责任有限公司	用作蛋白激酶抑制剂的化合物和组合物
JP4800216B2 (ja)	2003-10-24	2011-10-26	エグゼリクシス，インコーポレイテッド	ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
JP2007511575A (ja)	2003-11-21	2007-05-10	ノバルティスアクチエンゲゼルシャフト	タンパク質キナーゼ阻害剤としての１ｈ−イミダゾキノリン誘導体
TR200808208T1 (tr)	2003-12-09	2008-12-22	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Bir immün tepkinin bastırılması veya proliferatif bir hastalığın tedavisi
WO2005117909A2 (en)	2004-04-23	2005-12-15	Exelixis, Inc.	Kinase modulators and methods of use
US7994172B2 (en)	2004-12-28	2011-08-09	Exelixis, Inc.	[1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
GB0501999D0 (en)	2005-02-01	2005-03-09	Sentinel Oncology Ltd	Pharmaceutical compounds
EP1902032A1 (en)	2005-06-22	2008-03-26	Astex Therapeutics Limited	Pharmaceutical compounds
UA99284C2 (ru)	2007-05-11	2012-08-10	Елі Ліллі Енд Компані	ИНГИБИТОРЫ р70 S6-КИНАЗЫ
DE102007032739A1 (de)	2007-07-13	2009-01-15	Merck Patent Gmbh	Chinazolinamidderivate
BRPI1008325A2 (pt) *	2009-02-11	2020-08-25	Merck Patent Gmbh	carboxamidas azaeterocíclicas de amino
UA110113C2 (xx) *	2010-07-29	2015-11-25		Біциклічні азагетероциклічні карбоксаміди
BR112013002212A2 (pt) *	2010-07-29	2017-09-26	Merck Patent Gmbh	carboxamidas aza-heterocíclicas de aminas cíclicas

2011
- 2011-11-11 WO PCT/EP2011/005691 patent/WO2012069146A1/en not_active Ceased
- 2011-11-11 ES ES11785338.2T patent/ES2594404T3/es active Active
- 2011-11-11 UA UAA201307880A patent/UA112167C2/uk unknown
- 2011-11-11 SG SG2013038054A patent/SG190318A1/en unknown
- 2011-11-11 PE PE2013001281A patent/PE20140966A1/es active IP Right Grant
- 2011-11-11 LT LTEP11785338.2T patent/LT2643313T/lt unknown
- 2011-11-11 PL PL11785338T patent/PL2643313T3/pl unknown
- 2011-11-11 HU HUE11785338A patent/HUE028967T2/en unknown
- 2011-11-11 KR KR1020137015932A patent/KR101894116B1/ko active Active
- 2011-11-11 MX MX2013005751A patent/MX355325B/es active IP Right Grant
- 2011-11-11 EA EA201300610A patent/EA023821B1/ru not_active IP Right Cessation
- 2011-11-11 MY MYPI2013700817A patent/MY186456A/en unknown
- 2011-11-11 NZ NZ612224A patent/NZ612224A/en unknown
- 2011-11-11 AU AU2011334173A patent/AU2011334173B2/en active Active
- 2011-11-11 HR HRP20161183TT patent/HRP20161183T1/hr unknown
- 2011-11-11 CN CN201180056687.5A patent/CN103228649B/zh active Active
- 2011-11-11 BR BR112013012488-1A patent/BR112013012488B1/pt active IP Right Grant
- 2011-11-11 EP EP11785338.2A patent/EP2643313B9/en active Active
- 2011-11-11 PT PT117853382T patent/PT2643313T/pt unknown
- 2011-11-11 CA CA2818706A patent/CA2818706C/en active Active
- 2011-11-11 RS RS20160817A patent/RS55204B1/sr unknown
- 2011-11-11 JP JP2013540255A patent/JP5897590B2/ja active Active
- 2011-11-11 SI SI201130973A patent/SI2643313T1/sl unknown
- 2011-11-11 DK DK11785338.2T patent/DK2643313T3/en active
- 2011-11-11 US US13/989,199 patent/US8946247B2/en active Active
- 2011-11-23 AR ARP110104360A patent/AR093725A1/es not_active Application Discontinuation
2013
- 2013-05-08 IL IL226233A patent/IL226233A/en active IP Right Grant
- 2013-05-22 CL CL2013001459A patent/CL2013001459A1/es unknown
- 2013-06-17 CO CO13144136A patent/CO6721019A2/es unknown
- 2013-06-21 ZA ZA2013/04637A patent/ZA201304637B/en unknown

Also Published As

Publication number	Publication date
CN103228649B (zh)	2015-11-25
AU2011334173A1 (en)	2013-05-02
EA023821B1 (ru)	2016-07-29
KR20130130753A (ko)	2013-12-02
CN103228649A (zh)	2013-07-31
PL2643313T3 (pl)	2017-03-31
HUE028967T2 (en)	2017-01-30
SG190318A1 (en)	2013-06-28
BR112013012488A2 (pt)	2016-07-19
CO6721019A2 (es)	2013-07-31
PE20140966A1 (es)	2014-08-06
HRP20161183T1 (hr)	2016-11-04
WO2012069146A1 (en)	2012-05-31
ES2594404T3 (es)	2016-12-20
EP2643313A1 (en)	2013-10-02
MY186456A (en)	2021-07-22
SI2643313T1 (sl)	2016-11-30
PT2643313T (pt)	2016-10-11
UA112167C2 (uk)	2016-08-10
US20130252942A1 (en)	2013-09-26
AU2011334173B2 (en)	2015-07-16
IL226233A0 (en)	2013-07-31
ZA201304637B (en)	2014-03-26
JP2013544257A (ja)	2013-12-12
CL2013001459A1 (es)	2013-12-27
MX2013005751A (es)	2013-08-01
RS55204B1 (sr)	2017-01-31
EP2643313B1 (en)	2016-06-29
EP2643313B9 (en)	2017-02-22
MX355325B (es)	2018-04-16
HK1188444A1 (zh)	2014-05-02
AR093725A1 (es)	2015-06-24
BR112013012488B1 (pt)	2021-08-31
CA2818706A1 (en)	2012-05-31
IL226233A (en)	2017-07-31
KR101894116B1 (ko)	2018-08-31
JP5897590B2 (ja)	2016-03-30
US8946247B2 (en)	2015-02-03
NZ612224A (en)	2015-01-30
CA2818706C (en)	2019-07-23
EA201300610A1 (ru)	2013-12-30
DK2643313T3 (en)	2016-10-24

Publication	Publication Date	Title
ZA201304637B (en)	2014-03-26	Quinazoline carboxamide azetidines
IL226904A (en)	2015-05-31	Inganol-3-acetylates iii and Inganol-3-carbamates
EP2566328A4 (en)	2013-10-16	indazoles
IL220939A0 (en)	2012-09-24	Compounds and methods
EP2523664A4 (en)	2013-06-26	COMPOUNDS AND METHODS
SI3184136T1 (sl)	2021-11-30	Injektor
GB201213680D0 (en)	2012-09-12	Tent
EP2589693A4 (en)	2014-05-14	NANO FIBER
IL220812A0 (en)	2012-08-30	Compounds and methods
ZA201303073B (en)	2014-09-25	Construction block
TWI372081B (en)	2012-09-11	Showerhead
PL2385261T3 (pl)	2013-09-30	Śruba samogwintująca
PL2577075T3 (pl)	2015-01-30	Zespół mocujący
PL2577074T3 (pl)	2016-06-30	Wkręt samowiercący
PL2590966T3 (pl)	2017-05-31	Związki chinazolinowe
GB201004450D0 (en)	2010-05-05	Compounds and methods relating thereto
PL2468952T3 (pl)	2013-11-29	Rafinator
SG10201508549UA (en)	2015-11-27	Modified tamavidin
GB201004491D0 (en)	2010-05-05	Quinazoline analogues
PL2430948T3 (pl)	2014-01-31	Wyciąg szafy
PL119374U1 (pl)	2012-04-10	Anemostat
TWM388579U (en)	2010-09-11	Self-drilling screw
AU4937P (en)	2014-10-21	FlatinsulGL Myoporum insulare
PL392421A1 (pl)	2012-03-26	Kształtownik
GB201012097D0 (en)	2010-09-01	Optionzeyes threading