LT2799090T - Kontrastinių agentų farmacinės kompozicijos gamybos būdas - Google Patents

Kontrastinių agentų farmacinės kompozicijos gamybos būdas

Info

Publication number
LT2799090T
LT2799090T LTEP14165008.5T LT14165008T LT2799090T LT 2799090 T LT2799090 T LT 2799090T LT 14165008 T LT14165008 T LT 14165008T LT 2799090 T LT2799090 T LT 2799090T
Authority
LT
Lithuania
Prior art keywords
preparing
pharmaceutical formulation
contrast agents
agents
contrast
Prior art date
Application number
LTEP14165008.5T
Other languages
English (en)
Inventor
Dominique Meyer
Claire Corot
Marc Port
Vincent Barbotin
Bruno Bonnemain
Original Assignee
Guerbet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40955314&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT2799090(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0851055A external-priority patent/FR2927539B1/fr
Application filed by Guerbet filed Critical Guerbet
Publication of LT2799090T publication Critical patent/LT2799090T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
LTEP14165008.5T 2008-02-19 2009-02-18 Kontrastinių agentų farmacinės kompozicijos gamybos būdas LT2799090T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0851055A FR2927539B1 (fr) 2008-02-19 2008-02-19 Procede de preparation d'une formulation pharmaceutique d'agents de contraste.
EP08154745 2008-04-17
US12/155,997 US20090208421A1 (en) 2008-02-19 2008-06-12 Process for preparing a pharmaceutical formulation of contrast agents

Publications (1)

Publication Number Publication Date
LT2799090T true LT2799090T (lt) 2016-10-10

Family

ID=40955314

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP14165006.9T LT2799089T (lt) 2008-02-19 2009-02-18 Kontrastinio agento farmacinės kompozicijos gamybos būdas
LTEP14165008.5T LT2799090T (lt) 2008-02-19 2009-02-18 Kontrastinių agentų farmacinės kompozicijos gamybos būdas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP14165006.9T LT2799089T (lt) 2008-02-19 2009-02-18 Kontrastinio agento farmacinės kompozicijos gamybos būdas

Country Status (17)

Country Link
US (6) US20090208421A1 (lt)
EP (6) EP3159014A1 (lt)
JP (3) JP5469615B2 (lt)
KR (1) KR101063060B1 (lt)
CN (1) CN101977633B (lt)
BR (1) BRPI0908221B1 (lt)
CA (1) CA2714118C (lt)
CY (2) CY1115259T1 (lt)
DE (1) DE202008010019U1 (lt)
DK (3) DK2799090T4 (lt)
ES (3) ES2593127T5 (lt)
HR (2) HRP20140537T1 (lt)
HU (2) HUE031091T2 (lt)
LT (2) LT2799089T (lt)
PL (3) PL2242515T3 (lt)
PT (3) PT2242515E (lt)
WO (1) WO2009103744A2 (lt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
FR2945448B1 (fr) * 2009-05-13 2012-08-31 Guerbet Sa Procede de preparation d'une formulation pharmaceutique de chelate de lanthanide sous forme de poudre.
EP2338874A1 (en) * 2009-12-16 2011-06-29 Bracco Imaging S.p.A Process for the preparation of chelated compounds
PT2941233T (pt) * 2013-01-07 2020-11-13 Univ Pennsylvania Composições e métodos para tratar linfoma cutâneo de células t
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
EP2786768A1 (en) 2013-04-04 2014-10-08 Agfa Healthcare Process for preparing a material comprising a macrocyclic ligand and for producing a pharmaceutical formulation comprising said ligand with a lanthanide
KR102231121B1 (ko) * 2013-04-26 2021-03-23 게르브 조영제 제형 및 이와 관련된 제조 방법
KR101466602B1 (ko) * 2013-05-31 2014-12-01 동국제약 주식회사 메글루민 가도테레이트를 포함하는 조영제 조성물의 제조방법
AT516104B1 (de) 2014-07-31 2016-08-15 Sanochemia Pharmazeutika Ag Verfahren zum Herstellen einer flüssigen pharmazeutischen Zubereitung
KR101646211B1 (ko) * 2014-11-12 2016-08-05 (주)디아이테크 자기공명영상용 조영제의 제조방법
GB201421162D0 (en) 2014-11-28 2015-01-14 Ge Healthcare As Lanthanide complex formulations
GB201421163D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Formulations of metal complexes
GB201421161D0 (en) * 2014-11-28 2015-01-14 Ge Healthcare As Metal complex formulations
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
US20170035461A1 (en) * 2015-08-03 2017-02-09 Jeffery Deal Reversible tattoo colorant and method
DE102015013939A1 (de) 2015-09-15 2017-03-16 be imaging GmbH Verfahren zur Herstellung von Gadotersäure (Gd-DOTA)- Komplexen
JP6415715B2 (ja) 2015-09-30 2018-10-31 デューク・ユニヴァーシティ アスコルベート製剤及び造影剤としての使用方法
KR101625656B1 (ko) * 2015-10-16 2016-05-30 최경석 자기공명영상용 조영제의 제조방법
WO2017093336A1 (en) * 2015-11-30 2017-06-08 Ge Healthcare As Formulations comprising a combination of mri contrast agents
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
WO2018069179A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
WO2018069176A1 (en) 2016-10-12 2018-04-19 T2Pharma Gmbh Method of preparing formulations of lanthanide metal complexes of macrocyclic chelates
EP3315141B1 (de) * 2016-10-28 2020-10-21 B.E. Imaging GmbH Verfahren zur herstellung von pharmazeutischen formulierungen enthaltend chelatkomplexe von gadolinium mit reduziertem gehalt an toxischen verunreinigungen
RU2755181C2 (ru) 2016-11-28 2021-09-14 Байер Фарма Акциенгезельшафт Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
WO2018115314A1 (en) 2016-12-21 2018-06-28 Ge Healthcare As Tetraazabicyclo-macrocycle based manganese chelate compounds suitable as mri imaging agents
CN110114093A (zh) * 2016-12-29 2019-08-09 创意有限责任公司 无溶剂钆造影剂
US20190269805A1 (en) * 2016-12-29 2019-09-05 Inventure, LLC Solvent-free gadolinium contrast agents
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
AU2018261888B2 (en) 2017-05-05 2022-06-30 Centre For Probe Development And Commercialization Pharmacokinetic enhancements of bifunctional chelates and uses thereof
WO2018204872A2 (en) 2017-05-05 2018-11-08 Fusion Pharmaceuticals Inc. Igf-1r monoclonal antibodies and uses thereof
WO2019020662A1 (de) * 2017-07-27 2019-01-31 Sanochemia Pharmazeutika Ag Zubereitung enthaltend ein kontrastmittel, und verfahren zum herstellen
FR3072281B1 (fr) * 2017-10-13 2020-12-04 Nh Theraguix Nanovecteurs et utilisations, en particulier pour le traitement de tumeurs
CN111712477B (zh) 2017-12-20 2024-02-02 通用电气公司 阴离子螯合物化合物
AT521001B1 (de) * 2018-02-23 2020-10-15 Sanochemia Pharmazeutika Ag Herstellungsverfahren für ein Kontrastmittel
IL321215B2 (en) 2018-11-23 2026-05-01 Bayer Ag Contrast media formulation and process for its preparation
JP2022517193A (ja) * 2019-01-03 2022-03-07 アイオンパス， インク． イオンビームイメージングのための組成物および試薬
FR3091873B1 (fr) * 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
MX2021015467A (es) * 2019-06-14 2022-01-24 Edinburgh Molecular Imaging Ltd Compuestos y metodos de uso.
EP4048322A1 (en) 2019-10-25 2022-08-31 Bracco Imaging SPA Pharmaceutical compositions of gd-based contrast agents
GB201919073D0 (en) 2019-12-20 2020-02-05 Ge Healthcare As Novel manufacturing process
TWI779284B (zh) * 2020-05-06 2022-10-01 商之器科技股份有限公司 用於影像資料標註的裝置
JP2023529488A (ja) 2020-06-10 2023-07-10 ジャステザ イマゲン，エス．エー．ユー 高純度テトラキセタン（ｄｏｔａ）からガドテル酸メグルミンを得るための手順および注射用ガレヌス製剤の調製におけるその使用
WO2022165424A1 (en) 2021-02-01 2022-08-04 Inventure, LLC Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents
CN113801071B (zh) * 2021-09-14 2023-04-07 安徽普利药业有限公司 一种钆特酸葡甲胺的精制方法
US20250041460A1 (en) * 2023-08-04 2025-02-06 Inventure, LLC Lanthanide-based contrast agents having improved stability and methods for their production and purification
CN119612783B (zh) * 2024-12-23 2025-09-02 欣格瑞(山东)化学有限公司 一种硫酸钡锶除垢剂的制备方法及其应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US5082649A (en) 1987-06-30 1992-01-21 Mallinckrodt Medical, Inc. Method for enhancing the safety of metal-ligand chelates as magnetic resonance imaging agents by addition of calcium ions
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3640708C2 (de) 1986-11-28 1995-05-18 Schering Ag Verbesserte metallhaltige Pharmazeutika
US5049667A (en) † 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3854717T3 (de) 1987-06-30 1999-04-15 Mallinckrodt, Inc. (N.D.Ges.Des Staates Delaware), St. Louis, Mo. Verfahren zur erhöhung der sicherheit von metall-ligandchelaten als röntgenstrahlen-kontrastmittel.
JP2854905B2 (ja) * 1988-09-27 1999-02-10 サリユーター・インコーポレイテツド キレート組成物
JPH02173483A (ja) 1988-12-23 1990-07-04 Komatsu Ltd 高速流量制御弁
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US4967447A (en) 1989-09-25 1990-11-06 Romaine Jeffrey L Fish slicer and method of frying fish
US5650133A (en) 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
GB9000564D0 (en) 1990-01-10 1990-03-14 Dow Rheinmuenster Modified polyoxyethlene epoxy resin amphiphiles and stable aqueous epoxy dispersions thereof
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
US7385041B2 (en) * 1990-04-25 2008-06-10 Bracco International B.V. Dual functioning excipient for metal chelate contrast agents
CA2039399C (en) 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
SG52470A1 (en) * 1992-04-13 1998-09-28 Dow Chemical Co Process for preparing macrocyclic chelating agents and formation of chelates and conjugates thereof
GB9318550D0 (en) 1993-09-07 1993-10-20 Nycomed Salutar Inc Chelants
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
TWI284539B (en) 2001-07-30 2007-08-01 Epix Pharm Inc A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
JP2005534697A (ja) * 2002-08-06 2005-11-17 エピックス ファーマシューティカルズ， インコーポレイテッド ペプチド凝集体
US20100098640A1 (en) 2005-06-20 2010-04-22 Cohen Seth M Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US20090053137A1 (en) 2006-03-15 2009-02-26 Moore Dennis A Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof
WO2007121453A2 (en) 2006-04-17 2007-10-25 The Regents Of The University Of California 2-hydroxy-1-oxo 1,2 dihydro isoquinoline chelating agents
US20090208421A1 (en) * 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents

Also Published As

Publication number Publication date
PL2799090T3 (pl) 2017-08-31
US20160235867A1 (en) 2016-08-18
BRPI0908221A2 (pt) 2018-03-20
HUE030219T2 (en) 2017-04-28
US20110129425A1 (en) 2011-06-02
ES2593127T5 (es) 2020-09-25
ES2593127T9 (es) 2017-05-08
DK2799090T3 (en) 2016-10-03
HUE031091T2 (en) 2017-06-28
US20090208421A1 (en) 2009-08-20
WO2009103744A3 (en) 2009-12-17
CY1115259T1 (el) 2017-01-04
DE202008010019U1 (de) 2009-08-06
EP2242515B9 (en) 2014-10-01
EP2799090B9 (en) 2016-12-21
KR101063060B1 (ko) 2011-09-07
DK2799090T4 (da) 2020-05-18
JP6422460B2 (ja) 2018-11-14
EP2799090A2 (en) 2014-11-05
LT2799089T (lt) 2016-11-10
US20130336898A1 (en) 2013-12-19
US9655983B2 (en) 2017-05-23
JP2016117778A (ja) 2016-06-30
EP2799089A3 (en) 2015-03-04
EP3159014A1 (en) 2017-04-26
US9907866B2 (en) 2018-03-06
PL2799090T5 (pl) 2020-07-13
CA2714118C (en) 2017-03-28
ES2477541T3 (es) 2014-07-17
PT2799089T (pt) 2016-10-25
EP2799090B1 (en) 2016-06-29
KR20100133976A (ko) 2010-12-22
CN101977633A (zh) 2011-02-16
JP5469615B2 (ja) 2014-04-16
EP2799089B1 (en) 2016-08-03
HRP20161312T1 (hr) 2016-12-16
ES2593127T3 (es) 2016-12-05
BRPI0908221B1 (pt) 2021-07-13
EP2799090B2 (en) 2020-03-04
DK2799089T3 (en) 2016-11-21
PL2799089T3 (pl) 2017-08-31
JP2014114306A (ja) 2014-06-26
US20160235868A1 (en) 2016-08-18
CN101977633B (zh) 2012-08-29
DK2242515T3 (da) 2014-07-07
EP2799090A3 (en) 2015-01-14
HRP20140537T1 (hr) 2014-07-18
PL2242515T3 (pl) 2014-08-29
PT2799090T (pt) 2016-09-28
EP2799089B9 (en) 2017-09-06
CA2714118A1 (en) 2009-08-27
WO2009103744A2 (en) 2009-08-27
HRP20161312T2 (hr) 2018-01-26
EP2799089A2 (en) 2014-11-05
JP2011514334A (ja) 2011-05-06
JP5985523B2 (ja) 2016-09-06
EP3620179A1 (en) 2020-03-11
EP2242515A2 (en) 2010-10-27
ES2597782T3 (es) 2017-01-23
US20170189563A1 (en) 2017-07-06
EP2591807A1 (en) 2013-05-15
CY1118985T1 (el) 2018-01-10
EP2242515B1 (en) 2014-04-02
DK2799090T5 (en) 2017-04-18
US9636427B2 (en) 2017-05-02
PT2242515E (pt) 2014-07-11

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