LT2940030T - P1,p4-di (uridino 5`-) tetrafosfato gamybos būdas - Google Patents
P1,p4-di (uridino 5`-) tetrafosfato gamybos būdasInfo
- Publication number
- LT2940030T LT2940030T LTEP13869663.8T LT13869663T LT2940030T LT 2940030 T LT2940030 T LT 2940030T LT 13869663 T LT13869663 T LT 13869663T LT 2940030 T LT2940030 T LT 2940030T
- Authority
- LT
- Lithuania
- Prior art keywords
- tetraphosphate
- uridine
- producing
- Prior art date
Links
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title 2
- YDHWWBZFRZWVHO-UHFFFAOYSA-H [oxido-[oxido(phosphonatooxy)phosphoryl]oxyphosphoryl] phosphate Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O YDHWWBZFRZWVHO-UHFFFAOYSA-H 0.000 title 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 title 1
- 229940045145 uridine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012287578 | 2012-12-28 | ||
| PCT/JP2013/083100 WO2014103704A1 (ja) | 2012-12-28 | 2013-12-10 | Ｐ１，ｐ４－ジ（ウリジン５'－）テトラホスフェートの製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT2940030T true LT2940030T (lt) | 2017-07-10 |
Family
ID=51020794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP13869663.8T LT2940030T (lt) | 2012-12-28 | 2013-12-10 | P1,p4-di (uridino 5`-) tetrafosfato gamybos būdas |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10179799B2 (lt) |
| EP (1) | EP2940030B1 (lt) |
| JP (1) | JP6049760B2 (lt) |
| KR (1) | KR102024700B1 (lt) |
| CN (1) | CN105026414B (lt) |
| CA (1) | CA2896455C (lt) |
| CY (1) | CY1119372T1 (lt) |
| DK (1) | DK2940030T3 (lt) |
| ES (1) | ES2629743T3 (lt) |
| HR (1) | HRP20171333T1 (lt) |
| HU (1) | HUE035675T2 (lt) |
| LT (1) | LT2940030T (lt) |
| PL (1) | PL2940030T3 (lt) |
| PT (1) | PT2940030T (lt) |
| RS (1) | RS56227B1 (lt) |
| SI (1) | SI2940030T1 (lt) |
| SM (1) | SMT201700405T1 (lt) |
| WO (1) | WO2014103704A1 (lt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109843901B (zh) * | 2016-10-25 | 2022-04-26 | Yamasa 酱油株式会社 | P1,p4-二(尿苷5’-)四磷酸的纯化方法 |
| CN108164577A (zh) * | 2017-04-28 | 2018-06-15 | 广东众生药业股份有限公司 | 一种p1，p4-二（尿苷-5’-四磷酸）钠盐的工业化制备方法 |
| CN107056859A (zh) * | 2017-04-28 | 2017-08-18 | 广东众生药业股份有限公司 | 一种高纯度p1，p4‑二（尿苷‑5’‑四磷酸）盐的制备方法 |
| KR102504764B1 (ko) | 2017-06-21 | 2023-03-02 | 주식회사 종근당 | 디뉴클레오사이드 폴리포스페이트 화합물의 제조방법 |
| CN110218233B (zh) * | 2018-03-01 | 2023-11-14 | 江苏恒瑞医药股份有限公司 | 一种p1,p4-二（尿苷5`-）四磷酸盐的制备方法 |
| CN109021049B (zh) * | 2018-06-14 | 2020-12-08 | 扬子江药业集团北京海燕药业有限公司 | 一种尿苷5′-二磷酸-苯并咪唑二钠的合成方法 |
| CN110655545B (zh) * | 2018-06-28 | 2022-09-09 | 上海致根医药科技有限公司 | P1，p4-二(尿苷5’-)四磷酸酯的制备方法 |
| KR20200106738A (ko) | 2019-03-05 | 2020-09-15 | 주식회사 파마코스텍 | P1,p4-디(우리딘 5'-)테트라포스페이트, 이의 염 또는 이의 수화물의 신규한 제조방법 |
| CN110590887B (zh) * | 2019-09-04 | 2020-12-15 | 江苏金殳医药科技有限公司 | 一种磷酸酯的制备方法 |
| CN115011113B (zh) * | 2019-12-18 | 2023-07-21 | 江苏集萃先进高分子材料研究所有限公司 | 一种阻燃材料及其制备方法 |
| KR102790402B1 (ko) * | 2019-12-18 | 2025-04-03 | 주식회사 종근당 | 우리딘 5’-디인산(udp), 이의 염 또는 이의 수화물의 제조방법 |
| CN113527394A (zh) * | 2020-04-18 | 2021-10-22 | 上海键合医药科技有限公司 | 一种地夸磷索的纯化方法 |
| CN111662350B (zh) * | 2020-07-07 | 2022-06-07 | 南京宸翔医药研究有限责任公司 | 一种绿色化智能化高纯度地夸磷索四钠的制备方法 |
| WO2022212442A1 (en) | 2021-03-31 | 2022-10-06 | Modernatx, Inc. | Synthesis of trinucleotide and tetranucleotide caps for mrna production |
| WO2024185734A1 (ja) | 2023-03-03 | 2024-09-12 | 株式会社ナティアス | ポリリン酸化ヌクレオシド、ポリリン酸化ヌクレオシドの合成に用いられるリン酸部活性化ヌクレオチド及びその合成方法、ならびにリン酸部活性化ヌクレオチドを用いたポリリン酸化ヌクレオシドの合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008024169A1 (en) * | 2006-07-21 | 2008-02-28 | Glsynthesis, Inc. | Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use |
| JP5051422B2 (ja) | 2006-07-21 | 2012-10-17 | アイシン精機株式会社 | タイヤ空気圧監視システム |
| JP5193040B2 (ja) | 2006-07-26 | 2013-05-08 | ヤマサ醤油株式会社 | ジ（ピリミジンヌクレオシド５’−）ポリホスフェートの製造法 |
-
2013
- 2013-12-10 US US14/758,102 patent/US10179799B2/en active Active
- 2013-12-10 RS RS20170824A patent/RS56227B1/sr unknown
- 2013-12-10 PL PL13869663T patent/PL2940030T3/pl unknown
- 2013-12-10 EP EP13869663.8A patent/EP2940030B1/en active Active
- 2013-12-10 DK DK13869663.8T patent/DK2940030T3/en active
- 2013-12-10 LT LTEP13869663.8T patent/LT2940030T/lt unknown
- 2013-12-10 SI SI201330744T patent/SI2940030T1/sl unknown
- 2013-12-10 HU HUE13869663A patent/HUE035675T2/hu unknown
- 2013-12-10 KR KR1020157017372A patent/KR102024700B1/ko active Active
- 2013-12-10 JP JP2014554298A patent/JP6049760B2/ja active Active
- 2013-12-10 CN CN201380074088.5A patent/CN105026414B/zh active Active
- 2013-12-10 ES ES13869663.8T patent/ES2629743T3/es active Active
- 2013-12-10 CA CA2896455A patent/CA2896455C/en active Active
- 2013-12-10 HR HRP20171333TT patent/HRP20171333T1/hr unknown
- 2013-12-10 PT PT138696638T patent/PT2940030T/pt unknown
- 2013-12-10 SM SM20170405T patent/SMT201700405T1/it unknown
- 2013-12-10 WO PCT/JP2013/083100 patent/WO2014103704A1/ja not_active Ceased
-
2017
- 2017-09-07 CY CY20171100946T patent/CY1119372T1/el unknown
-
2018
- 2018-11-30 US US16/206,380 patent/US11208428B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN105026414B (zh) | 2017-06-23 |
| US10179799B2 (en) | 2019-01-15 |
| PT2940030T (pt) | 2017-09-11 |
| WO2014103704A1 (ja) | 2014-07-03 |
| CA2896455A1 (en) | 2014-07-03 |
| CY1119372T1 (el) | 2018-02-14 |
| RS56227B1 (sr) | 2017-11-30 |
| HUE035675T2 (hu) | 2018-05-28 |
| SI2940030T1 (sl) | 2017-09-29 |
| KR102024700B1 (ko) | 2019-09-24 |
| SMT201700405T1 (it) | 2017-09-07 |
| JP6049760B2 (ja) | 2016-12-21 |
| DK2940030T3 (en) | 2017-07-24 |
| US20160194347A1 (en) | 2016-07-07 |
| CA2896455C (en) | 2021-04-20 |
| US20190092803A1 (en) | 2019-03-28 |
| EP2940030A1 (en) | 2015-11-04 |
| ES2629743T3 (es) | 2017-08-14 |
| KR20150100708A (ko) | 2015-09-02 |
| EP2940030B1 (en) | 2017-06-14 |
| JPWO2014103704A1 (ja) | 2017-01-12 |
| HRP20171333T1 (hr) | 2017-11-03 |
| EP2940030A4 (en) | 2016-09-14 |
| PL2940030T3 (pl) | 2017-11-30 |
| CN105026414A (zh) | 2015-11-04 |
| US11208428B2 (en) | 2021-12-28 |
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