LT3087094T - Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai - Google Patents

Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai

Info

Publication number
LT3087094T
LT3087094T LTEPPCT/EP2013/078073T LT13078073T LT3087094T LT 3087094 T LT3087094 T LT 3087094T LT 13078073 T LT13078073 T LT 13078073T LT 3087094 T LT3087094 T LT 3087094T
Authority
LT
Lithuania
Prior art keywords
beta
elastase inhibitors
hairpin peptidomimetics
selective
selective elastase
Prior art date
Application number
LTEPPCT/EP2013/078073T
Other languages
English (en)
Inventor
Frank Otto Gombert
Daniel Obrecht
Odile Sellier-Kessler
Alexander Lederer
Christian Ludin
Manuella Schmitt-Billet
Steffen Weinbrenner
Original Assignee
Spexis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spexis Ag filed Critical Spexis Ag
Publication of LT3087094T publication Critical patent/LT3087094T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
LTEPPCT/EP2013/078073T 2013-12-27 2013-12-27 Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai LT3087094T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2013/078073 WO2015096873A1 (en) 2013-12-27 2013-12-27 Beta-hairpin peptidomimetics as selective elastase inhibitors

Publications (1)

Publication Number Publication Date
LT3087094T true LT3087094T (lt) 2022-09-26

Family

ID=49911533

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/EP2013/078073T LT3087094T (lt) 2013-12-27 2013-12-27 Beta plaukų segtuko struktūros peptidų mimetikai, kaip selektyvūs elastazės slopikliai

Country Status (26)

Country Link
US (1) US10273267B2 (lt)
EP (1) EP3087094B1 (lt)
JP (1) JP6499183B2 (lt)
KR (1) KR102214694B1 (lt)
CN (1) CN106029689B (lt)
AU (1) AU2013409200B2 (lt)
BR (1) BR112016014916B1 (lt)
CA (1) CA2933660C (lt)
CY (1) CY1125542T1 (lt)
DK (1) DK3087094T3 (lt)
EA (1) EA201691330A1 (lt)
ES (1) ES2925747T3 (lt)
HR (1) HRP20221046T1 (lt)
HU (1) HUE059846T2 (lt)
IL (1) IL246175B (lt)
LT (1) LT3087094T (lt)
MX (1) MX389053B (lt)
NZ (1) NZ722025A (lt)
PL (1) PL3087094T3 (lt)
PT (1) PT3087094T (lt)
RS (1) RS63543B1 (lt)
SG (1) SG11201605122WA (lt)
SI (1) SI3087094T1 (lt)
SM (1) SMT202200393T1 (lt)
WO (1) WO2015096873A1 (lt)
ZA (1) ZA201604821B (lt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009008843A (es) 2007-02-28 2009-08-28 Polyphor Ltd Peptidomimeticos fijados a un patron.
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトPolyphor Ag 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体
US10676723B2 (en) * 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
HUE060119T2 (hu) * 2016-05-31 2023-02-28 Spexis Ag Béta-hairpin peptidomimetikum elasztáz gátló hatással és annak aeroszolos adagolási formái
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
HUE064089T2 (hu) 2020-04-16 2024-02-28 Mereo Biopharma 4 Ltd Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
CN114573686A (zh) * 2020-11-30 2022-06-03 中国医学科学院药物研究所 含有二硫键且具有抑制丝氨酸蛋白酶活性的多肽及其应用
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
GB9825854D0 (en) * 1998-11-25 1999-01-20 Univ Bristol Peptide
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
EP1856140B1 (en) * 2005-02-17 2013-12-25 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
JP6499182B2 (ja) * 2013-12-27 2019-04-10 ポリフォー・アクチェンゲゼルシャフトPolyphor Ag 選択的エラスターゼ阻害剤としてのβ−ヘアピンペプチド模倣体

Also Published As

Publication number Publication date
AU2013409200B2 (en) 2019-08-15
MX389053B (es) 2025-03-20
SG11201605122WA (en) 2016-07-28
KR20160102313A (ko) 2016-08-29
MX2016008318A (es) 2016-10-13
ZA201604821B (en) 2017-09-27
ES2925747T3 (es) 2022-10-19
EP3087094B1 (en) 2022-06-01
US10273267B2 (en) 2019-04-30
AU2013409200A1 (en) 2016-07-21
BR112016014916B1 (pt) 2022-10-04
EA201691330A1 (ru) 2016-10-31
HRP20221046T1 (hr) 2023-01-20
HUE059846T2 (hu) 2023-01-28
KR102214694B1 (ko) 2021-02-10
JP6499183B2 (ja) 2019-04-10
BR112016014916A2 (lt) 2017-08-08
CN106029689B (zh) 2021-09-28
CA2933660C (en) 2023-05-09
WO2015096873A1 (en) 2015-07-02
PT3087094T (pt) 2022-09-05
RS63543B1 (sr) 2022-09-30
SMT202200393T1 (it) 2022-11-18
JP2017504620A (ja) 2017-02-09
CA2933660A1 (en) 2015-07-02
PL3087094T3 (pl) 2022-09-26
CN106029689A (zh) 2016-10-12
EP3087094A1 (en) 2016-11-02
DK3087094T3 (da) 2022-08-29
NZ722025A (en) 2019-06-28
US20160333053A1 (en) 2016-11-17
IL246175A0 (en) 2016-07-31
CY1125542T1 (el) 2026-02-25
IL246175B (en) 2022-04-01
SI3087094T1 (sl) 2022-11-30

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