LT3152191T - Pagerintas duokarmicino provaistų gavimo būdas - Google Patents

Pagerintas duokarmicino provaistų gavimo būdas

Info

Publication number
LT3152191T
LT3152191T LTEP14728565.4T LT14728565T LT3152191T LT 3152191 T LT3152191 T LT 3152191T LT 14728565 T LT14728565 T LT 14728565T LT 3152191 T LT3152191 T LT 3152191T
Authority
LT
Lithuania
Prior art keywords
duocarmycin
prodrugs
making
improved process
improved
Prior art date
Application number
LTEP14728565.4T
Other languages
English (en)
Inventor
Tijl HUIJBRGTS
Ronald Christiaan Elgersma
Patrick Henry Beusker
Johannes Albertus Frederikus Joosten
Rudy Gerardus Elisabeth Coumans
Henri Johannes Spijker
Wiro Menge
Franciscus Mariuns Hendrikus DE GROOT
Original Assignee
Synthon Biopharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals B.V. filed Critical Synthon Biopharmaceuticals B.V.
Publication of LT3152191T publication Critical patent/LT3152191T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
LTEP14728565.4T 2014-06-05 2014-06-05 Pagerintas duokarmicino provaistų gavimo būdas LT3152191T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2014/061701 WO2015185142A1 (en) 2014-06-05 2014-06-05 Improved process for making duocarmycin prodrugs

Publications (1)

Publication Number Publication Date
LT3152191T true LT3152191T (lt) 2019-08-26

Family

ID=50896304

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP14728565.4T LT3152191T (lt) 2014-06-05 2014-06-05 Pagerintas duokarmicino provaistų gavimo būdas

Country Status (13)

Country Link
US (1) US9890159B2 (lt)
EP (1) EP3152191B1 (lt)
JP (1) JP6275881B2 (lt)
CN (1) CN106458892B (lt)
CY (1) CY1122025T1 (lt)
DK (1) DK3152191T3 (lt)
ES (1) ES2738211T3 (lt)
HR (1) HRP20191378T1 (lt)
HU (1) HUE045447T2 (lt)
LT (1) LT3152191T (lt)
PL (1) PL3152191T3 (lt)
PT (1) PT3152191T (lt)
WO (1) WO2015185142A1 (lt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
EP3108886B1 (en) 2010-04-21 2020-06-17 Syntarga B.V. Conjugates of cc-1065 analogs and bifunctional linkers
JP6342517B2 (ja) 2014-01-10 2018-06-13 シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． 改善されたインビボ抗腫瘍活性を示すデュオカルマイシンａｄｃ
RU2686085C2 (ru) 2014-01-10 2019-04-24 Синтон Байофармасьютикалс Б. В. Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия
HUE056023T2 (hu) 2014-05-22 2022-01-28 Byondis Bv Kapcsolt drogok helyspecifikus konjugációja ellenanyagokhoz, és a kapott ADC-k
TWI781098B (zh) 2016-04-15 2022-10-21 美商宏觀基因股份有限公司 新穎的ｂ７-ｈ３-結合分子、其抗體藥物綴合物及其使用方法
AU2018371966B2 (en) 2017-11-24 2021-02-25 Byondis B.V. Improved process for the synthesis of linker-drug vc-seco-DUBA
MX2021005484A (es) * 2018-11-09 2021-06-18 Byondis Bv Composiciones de conjugados de anticuerpo-farmaco que contienen duocarmicina filtrable y metodos relacionados.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009017394A1 (en) 2007-08-01 2009-02-05 Syntarga B.V. Substituted cc-1065 analogs and their conjugates
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CA2742568C (en) 2008-11-03 2017-09-26 Syntarga B.V. Novel cc-1065 analogs and their conjugates
EP3108886B1 (en) 2010-04-21 2020-06-17 Syntarga B.V. Conjugates of cc-1065 analogs and bifunctional linkers
TR201810856T4 (tr) 2014-01-10 2018-08-27 Synthon Biopharmaceuticals Bv CYS'le bağlı antikor-ilaç konjugatlarını saflaştırmak için usul.
HUE056023T2 (hu) 2014-05-22 2022-01-28 Byondis Bv Kapcsolt drogok helyspecifikus konjugációja ellenanyagokhoz, és a kapott ADC-k
WO2016046173A1 (en) 2014-09-22 2016-03-31 Synthon Biopharmaceuticals B.V. Pan-reactive antibodies to duocarmycins

Also Published As

Publication number Publication date
CN106458892B (zh) 2019-10-18
JP2017516822A (ja) 2017-06-22
CN106458892A (zh) 2017-02-22
PL3152191T3 (pl) 2019-10-31
PT3152191T (pt) 2019-08-30
JP6275881B2 (ja) 2018-02-07
HRP20191378T1 (hr) 2019-11-15
DK3152191T3 (da) 2019-08-12
HUE045447T2 (hu) 2019-12-30
CY1122025T1 (el) 2020-11-25
US20170145006A1 (en) 2017-05-25
WO2015185142A1 (en) 2015-12-10
EP3152191A1 (en) 2017-04-12
ES2738211T3 (es) 2020-01-20
US9890159B2 (en) 2018-02-13
EP3152191B1 (en) 2019-05-15

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