LT3369724T - Iopamidolio gamybos būdas - Google Patents

Iopamidolio gamybos būdas

Info

Publication number
LT3369724T
LT3369724T LTEP18162482.6T LT18162482T LT3369724T LT 3369724 T LT3369724 T LT 3369724T LT 18162482 T LT18162482 T LT 18162482T LT 3369724 T LT3369724 T LT 3369724T
Authority
LT
Lithuania
Prior art keywords
iopamidol
manufacture
Prior art date
Application number
LTEP18162482.6T
Other languages
English (en)
Inventor
Elisa Battistini
Federica Buonsanti
Daniela IMPERIO
Luciano Lattuada
Roberta Napolitano
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of LT3369724T publication Critical patent/LT3369724T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
LTEP18162482.6T 2013-11-05 2014-11-04 Iopamidolio gamybos būdas LT3369724T (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13191551 2013-11-05

Publications (1)

Publication Number Publication Date
LT3369724T true LT3369724T (lt) 2021-02-25

Family

ID=49517391

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP18162482.6T LT3369724T (lt) 2013-11-05 2014-11-04 Iopamidolio gamybos būdas
LTEP14796024.9T LT3066071T (lt) 2013-11-05 2014-11-04 Jopamidolio gamybos būdas

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP14796024.9T LT3066071T (lt) 2013-11-05 2014-11-04 Jopamidolio gamybos būdas

Country Status (22)

Country Link
US (3) US9950991B2 (lt)
EP (2) EP3369724B1 (lt)
JP (1) JP6454351B2 (lt)
KR (2) KR102382351B1 (lt)
CN (1) CN105705483B (lt)
AU (1) AU2014345727B2 (lt)
BR (1) BR112016010223B1 (lt)
CA (2) CA3001399C (lt)
DK (2) DK3369724T3 (lt)
ES (2) ES2674279T3 (lt)
HR (2) HRP20181122T1 (lt)
HU (2) HUE053751T2 (lt)
IL (1) IL245457B (lt)
LT (2) LT3369724T (lt)
MX (2) MX380203B (lt)
PL (2) PL3369724T3 (lt)
PT (2) PT3066071T (lt)
RU (1) RU2657238C2 (lt)
SI (2) SI3369724T1 (lt)
TR (1) TR201808527T4 (lt)
WO (1) WO2015067601A1 (lt)
ZA (1) ZA201602970B (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106366015B (zh) * 2015-07-22 2019-01-25 正大天晴药业集团股份有限公司 一种碘普罗胺的制备方法及其中间体
CN106366016B (zh) * 2015-07-22 2019-03-05 连云港润众制药有限公司 一种碘普罗胺的制备方法及其中间体
US11999757B2 (en) 2017-11-01 2024-06-04 Melinta Subsidiary Corp. Synthesis of boronate ester derivatives and uses thereof
CN109293526A (zh) * 2018-10-23 2019-02-01 湖北天舒药业有限公司 一种碘帕醇的合成及其合成中间体的制备
CN115397802B (zh) * 2020-02-14 2025-02-18 西恩斯科公司 用于矿物回收的新的起泡剂及其制备和使用方法
GB202009917D0 (en) * 2020-06-29 2020-08-12 Ge Healthcare As Process for the preparation of iopamidol
JP2024514435A (ja) 2021-03-22 2024-04-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニ セリノールの工業的合成
EP4359465A1 (en) * 2021-06-24 2024-05-01 Align Technology, Inc. Recovery of monomeric and oligomeric building blocks from polymeric materials
JP2024545278A (ja) 2021-12-20 2024-12-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニ 2,4,6-トリヨードイソフタル酸ビスアミドの製造方法
CN115010617B (zh) * 2022-07-11 2024-06-11 安徽普利药业有限公司 一种碘帕醇的制备方法
EP4534526A1 (en) 2023-10-04 2025-04-09 Bracco Imaging SPA Optimized process for the preparation of iopamidol

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (lt) * 1974-12-13 1978-12-29 Savac Ag
IT1256162B (it) 1992-10-27 1995-11-29 Zambon Spa Processo per la preparazione di un intermedio della sintesi organica
IT1274027B (it) 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1274676B (it) * 1994-04-14 1997-07-24 Zambon Spa Processo per la preparazione di 5-ammino-2,2-dialchil-1,3-diossani
IT1282674B1 (it) 1996-02-23 1998-03-31 Bracco Spa Processo per la purificazione di agenti contrastografici opacizzanti
US5763650A (en) 1995-05-23 1998-06-09 Fructamine S.P.A. Process for the preparation of a halosubstituted aromatic acid
KR100269080B1 (ko) 1995-05-23 2000-10-16 안토니오 칸탈루피 디카르복실산디클로라이드의제조방법
DE69601525T2 (de) 1995-05-23 1999-06-24 Fructamine S.P.A., Mozzo Verfahren zur herstellung von dicarbonsäurechlorid
IT1288114B1 (it) 1996-06-13 1998-09-10 Fructamine Spa Processo per la purificazione di un intermedio
IT1286522B1 (it) 1996-12-04 1998-07-15 Dibra Spa Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
IT1289520B1 (it) * 1996-12-24 1998-10-15 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
GB2331098A (en) 1997-11-07 1999-05-12 Nycomed Imaging As An N-Alkylation process
IT1299202B1 (it) 1998-05-08 2000-02-29 Dibra Spa Processo per la preparazione della s-n,n'-bis (2-idrossi-1- (idrossimetil)etil) -5-((2-idrossi-1-ossopropil)ammino)-2,4,6-triiodo
GB9825095D0 (en) 1998-11-16 1999-01-13 Nycomed Imaging As Chemical process
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319670B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'-
IT1319671B1 (it) * 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
WO2005019229A1 (en) * 2003-08-26 2005-03-03 Biocon Limited Process for purification of boronic acid and its derivatives
KR101318807B1 (ko) 2005-10-21 2013-10-16 비디오 테잎드 트랜스크립츠 피티와이 엘티디 천공된 역반사 트림을 제조하는 방법
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
JP5536087B2 (ja) * 2008-11-18 2014-07-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニ ヨウ化造影剤の製造方法
EP2243767A1 (en) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Process for the iodination of aromatic compounds
WO2011003894A1 (en) 2009-07-07 2011-01-13 Bracco Imaging Spa Process for the preparation of a iodinating agent
EP2394984A1 (en) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Process for the iodination of phenolic derivatives

Also Published As

Publication number Publication date
MX380203B (es) 2025-03-12
CN105705483B (zh) 2018-09-04
JP6454351B2 (ja) 2019-01-16
MX2016005829A (es) 2017-03-10
IL245457B (en) 2020-07-30
MX2020010367A (es) 2021-03-03
HRP20181122T1 (hr) 2018-09-21
HRP20210324T1 (hr) 2021-04-02
AU2014345727B2 (en) 2018-07-05
PT3369724T (pt) 2021-02-10
EP3066071B1 (en) 2018-04-18
RU2657238C2 (ru) 2018-06-09
EP3369724B1 (en) 2021-01-06
CA3001399C (en) 2020-06-30
DK3369724T3 (da) 2021-03-29
HUE053751T2 (hu) 2021-07-28
PL3369724T3 (pl) 2021-06-14
KR102265049B1 (ko) 2021-06-16
US10377700B2 (en) 2019-08-13
CA2927706C (en) 2018-05-29
ES2862349T3 (es) 2021-10-07
MX375753B (es) 2025-03-06
US9950991B2 (en) 2018-04-24
RU2016122022A (ru) 2017-12-11
US20160237026A1 (en) 2016-08-18
BR112016010223A2 (pt) 2018-05-02
LT3066071T (lt) 2018-09-10
TR201808527T4 (tr) 2018-07-23
DK3066071T3 (en) 2018-07-30
WO2015067601A1 (en) 2015-05-14
KR20210072832A (ko) 2021-06-17
US20190071392A1 (en) 2019-03-07
CA3001399A1 (en) 2015-05-14
KR20160081965A (ko) 2016-07-08
PL3066071T3 (pl) 2018-09-28
US20190077745A1 (en) 2019-03-14
PT3066071T (pt) 2018-06-25
IL245457A0 (en) 2016-06-30
ES2674279T3 (es) 2018-06-28
EP3066071A1 (en) 2016-09-14
EP3369724A1 (en) 2018-09-05
HUE039440T2 (hu) 2018-12-28
SI3066071T1 (en) 2018-08-31
ZA201602970B (en) 2017-07-26
CA2927706A1 (en) 2015-05-14
KR102382351B1 (ko) 2022-04-04
SI3369724T1 (sl) 2021-04-30
AU2014345727A1 (en) 2016-05-12
CN105705483A (zh) 2016-06-22
BR112016010223B1 (pt) 2021-05-25
JP2016539181A (ja) 2016-12-15

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