LT3386541T - Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą - Google Patents

Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą

Info

Publication number
LT3386541T
LT3386541T LTEP16818985.0T LT16818985T LT3386541T LT 3386541 T LT3386541 T LT 3386541T LT 16818985 T LT16818985 T LT 16818985T LT 3386541 T LT3386541 T LT 3386541T
Authority
LT
Lithuania
Prior art keywords
pharmaceutical formulation
aqueous pharmaceutical
antibody avelumab
avelumab
antibody
Prior art date
Application number
LTEP16818985.0T
Other languages
English (en)
Inventor
Gianluca Rinaldi
Alessandra Del Rio
Silvia Fratarcangeli
Senta VOSS
Markus Weigandt
Original Assignee
Merck Patent Gmbh
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54838201&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LT3386541(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh, Pfizer Inc. filed Critical Merck Patent Gmbh
Publication of LT3386541T publication Critical patent/LT3386541T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
LTEP16818985.0T 2015-12-07 2016-12-05 Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą LT3386541T (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15198233 2015-12-07
PCT/EP2016/002040 WO2017097407A1 (en) 2015-12-07 2016-12-05 Aqueous pharmaceutical formulation comprising anti-pd-1 antibody avelumab

Publications (1)

Publication Number Publication Date
LT3386541T true LT3386541T (lt) 2020-10-26

Family

ID=54838201

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP16818985.0T LT3386541T (lt) 2015-12-07 2016-12-05 Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą

Country Status (34)

Country Link
US (2) US11058769B2 (lt)
EP (2) EP3747466A1 (lt)
JP (1) JP6925337B2 (lt)
KR (1) KR102697026B1 (lt)
CN (1) CN108367072B (lt)
AR (1) AR107014A1 (lt)
AU (1) AU2016368099C1 (lt)
CA (1) CA3007481C (lt)
CL (1) CL2018001488A1 (lt)
CO (1) CO2018005525A2 (lt)
CY (1) CY1123358T1 (lt)
DK (1) DK3386541T3 (lt)
EA (1) EA201891339A1 (lt)
ES (1) ES2823279T3 (lt)
HR (1) HRP20201573T1 (lt)
HU (1) HUE050811T2 (lt)
IL (1) IL259563B (lt)
LT (1) LT3386541T (lt)
MX (1) MX389289B (lt)
MY (1) MY195681A (lt)
NZ (1) NZ743964A (lt)
PE (1) PE20181400A1 (lt)
PH (1) PH12018500894A1 (lt)
PL (1) PL3386541T3 (lt)
PT (1) PT3386541T (lt)
RS (1) RS61029B1 (lt)
SA (1) SA518391743B1 (lt)
SG (1) SG11201804758QA (lt)
SI (1) SI3386541T1 (lt)
SM (1) SMT202000497T1 (lt)
TW (1) TWI630917B (lt)
UA (1) UA123270C2 (lt)
WO (1) WO2017097407A1 (lt)
ZA (1) ZA201804534B (lt)

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KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-ｐｄ-ｌ1 항체 및 그의 용도
WO2015048312A1 (en) 2013-09-26 2015-04-02 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
PE20170255A1 (es) 2014-01-24 2017-03-22 Dana Farber Cancer Inst Inc Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
HUE045065T2 (hu) 2014-01-31 2019-12-30 Novartis Ag TIM-3 antitest molekulák és felhasználásaik
KR102442436B1 (ko) 2014-03-14 2022-09-15 노파르티스 아게 Lag-3에 대한 항체 분자 및 그의 용도
KR20170060042A (ko) 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
EP4245376A3 (en) 2014-10-14 2023-12-13 Novartis AG Antibody molecules to pd-l1 and uses thereof
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
HRP20211058T8 (hr) 2015-07-29 2021-11-26 Novartis Ag Kombinirane terapije koje sadrže molekule antitijela protiv lag-3
LT3386541T (lt) 2015-12-07 2020-10-26 Merck Patent Gmbh Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą
UA126905C2 (uk) 2016-06-13 2023-02-22 Ай-Маб Байофарма Юес Лімітед Антитіло до pd-l1 та його застосування
KR20190062515A (ko) 2016-10-06 2019-06-05 화이자 인코포레이티드 암의 치료를 위한 아벨루맙의 투약 용법
BR112019018401A2 (pt) * 2017-03-06 2020-04-07 Merck Patent Gmbh formulação aquosa de anticorpo anti-pd-l1
CN110914302A (zh) 2017-06-01 2020-03-24 赛托姆克斯治疗学股份有限公司 可活化抗pdl1抗体及其使用方法
CN114632150B (zh) 2017-11-02 2023-12-19 正大天晴药业集团股份有限公司 一种抗pd-l1人源化单克隆抗体的药物组合物
WO2019124946A1 (ko) * 2017-12-22 2019-06-27 삼성바이오에피스 주식회사 Vegf 길항제를 포함하는 액상 조성물
CN111819198A (zh) * 2017-12-28 2020-10-23 尤利乌斯·马克西米利安维尔茨堡大学 具有非FcγR依赖性激动活性的肿瘤坏死因子(TNF)受体超家族(TNFRSF)受体-激活抗体融合蛋白(具有非FcγR依赖性激动活性的TNFRSF受体-激活抗体融合蛋白；TRAAFFIAA)
WO2020020307A1 (en) 2018-07-25 2020-01-30 I-Mab Biopharma Co., Ltd. Anti-cd73 anti-pd-l1 bispecific antibodies
WO2020060183A1 (ko) * 2018-09-18 2020-03-26 삼성바이오에피스 주식회사 트라스투주맙 항체 안정화 액체 제제
KR20210096640A (ko) * 2018-11-29 2021-08-05 하버 바이오메드 테라푸틱스 리미티드 항-pd-l1 항체 제제
CN120241997A (zh) 2019-02-18 2025-07-04 伊莱利利公司 治疗性抗体制剂
TWI761869B (zh) * 2019-06-25 2022-04-21 大陸商信達生物製藥（蘇州）有限公司 包含抗cd47/pd-l1雙特異性抗體的製劑及其製備方法和用途
CN111420049A (zh) * 2019-08-22 2020-07-17 Biocad股份公司 抗-pd1抗体prolgolimab的水性药物组合物及其应用
TW202535466A (zh) 2019-09-09 2025-09-16 德商百靈佳殷格翰國際股份有限公司 抗-il-23p19抗體調配物
US12121565B2 (en) 2019-09-13 2024-10-22 Duke University Methods of treatment of specific cancers with NLRP3 inhibitors and anti-PD1/PD-L1 antibodies
US12380963B2 (en) 2019-10-14 2025-08-05 The Medical College Of Wisconsin, Inc. Gene expression signature of hyperprogressive disease (HPD) in patients after anti-PD-1 immunotherapy
EP4051321A4 (en) 2019-10-30 2023-11-22 Duke University IMMUNOTHERAPY WITH COMBINATION THERAPY INCLUDING AN IMMUNOTOXIN
US20220387529A1 (en) 2019-11-04 2022-12-08 Duke University Treatment for primary and metastatic cancer
US20230054413A1 (en) * 2019-12-13 2023-02-23 Samsung Bioepis Co., Ltd. Stable anti-pd1 antibody pharmaceutical formulations
WO2021126657A1 (en) * 2019-12-18 2021-06-24 Tesaro, Inc. Biopharmaceutical compositions and related methods
KR102683876B1 (ko) * 2020-11-11 2024-07-11 가톨릭대학교 산학협력단 표적 치료제의 치료 효과 증진을 위한 항체 기반 컨쥬게이트
AU2022302143A1 (en) 2021-07-02 2024-01-18 Yale University Compositions and methods for treating cancers
EP4395832A1 (en) 2021-08-31 2024-07-10 Yale University Compositions and methods for treating cancers
CN120813375A (zh) 2023-01-30 2025-10-17 凯玛布有限公司 抗体

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WO2015176033A1 (en) * 2014-05-15 2015-11-19 Bristol-Myers Squibb Company Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
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RU2714233C2 (ru) 2015-02-26 2020-02-13 Мерк Патент Гмбх Ингибиторы pd-1 / pd-l1 для лечения рака
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MX2017015937A (es) 2015-06-08 2018-12-11 Genentech Inc Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1.
MY193229A (en) 2015-06-16 2022-09-26 Merck Patent GmbH Pd-l1 antagonist combination treatments
JP2018529719A (ja) 2015-09-30 2018-10-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ａｌｋ陰性がんを処置するためのｐｄ−１系結合アンタゴニストおよびａｌｋ阻害剤の組合せ
LT3386541T (lt) 2015-12-07 2020-10-26 Merck Patent Gmbh Vandeninė farmacinė kompozicija, apimanti anti-pd-1 antikūną avelumabą
BR112019018401A2 (pt) 2017-03-06 2020-04-07 Merck Patent Gmbh formulação aquosa de anticorpo anti-pd-l1

Also Published As

Publication number Publication date
TW201725051A (zh) 2017-07-16
KR102697026B1 (ko) 2024-08-20
EP3386541A1 (en) 2018-10-17
US20210100903A1 (en) 2021-04-08
SI3386541T1 (sl) 2020-11-30
US11058769B2 (en) 2021-07-13
KR20180085801A (ko) 2018-07-27
CL2018001488A1 (es) 2018-09-14
JP2018536676A (ja) 2018-12-13
WO2017097407A1 (en) 2017-06-15
US20180369377A1 (en) 2018-12-27
AU2016368099A1 (en) 2018-07-19
JP6925337B2 (ja) 2021-08-25
ZA201804534B (en) 2020-11-25
SG11201804758QA (en) 2018-07-30
HRP20201573T1 (hr) 2020-12-11
AU2016368099C1 (en) 2023-10-12
CO2018005525A2 (es) 2018-08-10
BR112018010211A2 (pt) 2019-02-05
AR107014A1 (es) 2018-03-14
HUE050811T2 (hu) 2021-01-28
MX389289B (es) 2025-03-20
MX2018006875A (es) 2018-11-09
CA3007481C (en) 2024-01-30
CN108367072A (zh) 2018-08-03
IL259563A (en) 2018-07-31
RS61029B1 (sr) 2020-12-31
EP3386541B1 (en) 2020-07-08
PH12018500894A1 (en) 2018-11-05
EP3747466A1 (en) 2020-12-09
MY195681A (en) 2023-02-03
CN108367072B (zh) 2022-12-27
DK3386541T3 (da) 2020-09-28
CY1123358T1 (el) 2021-12-31
SA518391743B1 (ar) 2022-12-01
SMT202000497T1 (it) 2021-01-05
TWI630917B (zh) 2018-08-01
UA123270C2 (uk) 2021-03-10
HK1257781A1 (zh) 2019-10-25
ES2823279T3 (es) 2021-05-06
AU2016368099B2 (en) 2023-03-09
EA201891339A1 (ru) 2019-01-31
CA3007481A1 (en) 2017-06-15
IL259563B (en) 2021-05-31
PE20181400A1 (es) 2018-09-07
NZ743964A (en) 2023-03-31
PL3386541T3 (pl) 2021-04-06
PT3386541T (pt) 2020-10-12

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