LT3394266T - Nukleorūgštys, koduojančios pasikartojančias aminorūgščių sekas, turtingas prolino ir alanino liekanomis, kurios turi mažai kartotinų nukleotidų sekų - Google Patents
Nukleorūgštys, koduojančios pasikartojančias aminorūgščių sekas, turtingas prolino ir alanino liekanomis, kurios turi mažai kartotinų nukleotidų sekųInfo
- Publication number
- LT3394266T LT3394266T LTEP16828736.5T LT16828736T LT3394266T LT 3394266 T LT3394266 T LT 3394266T LT 16828736 T LT16828736 T LT 16828736T LT 3394266 T LT3394266 T LT 3394266T
- Authority
- LT
- Lithuania
- Prior art keywords
- repetitive
- proline
- amino acid
- nucleic acids
- acids encoding
- Prior art date
Links
- 230000003252 repetitive effect Effects 0.000 title 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 title 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/68—Stabilisation of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15202093 | 2015-12-22 | ||
| PCT/EP2016/082407 WO2017109087A1 (en) | 2015-12-22 | 2016-12-22 | Nucleic acids encoding repetitive amino acid sequences rich in proline and alanine residues that have low repetitive nucleotide sequences |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3394266T true LT3394266T (lt) | 2021-08-25 |
Family
ID=55129435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP16828736.5T LT3394266T (lt) | 2015-12-22 | 2016-12-22 | Nukleorūgštys, koduojančios pasikartojančias aminorūgščių sekas, turtingas prolino ir alanino liekanomis, kurios turi mažai kartotinų nukleotidų sekų |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US11401305B2 (lt) |
| EP (2) | EP3919623A1 (lt) |
| JP (1) | JP7065772B2 (lt) |
| KR (1) | KR102654180B1 (lt) |
| CN (1) | CN109153996B (lt) |
| AU (1) | AU2016378646B2 (lt) |
| BR (1) | BR112018012784A2 (lt) |
| CA (1) | CA3005115A1 (lt) |
| DK (1) | DK3394266T3 (lt) |
| EA (1) | EA201891127A1 (lt) |
| ES (1) | ES2877539T3 (lt) |
| HU (1) | HUE055267T2 (lt) |
| IL (1) | IL259352B (lt) |
| LT (1) | LT3394266T (lt) |
| MX (1) | MX2018007680A (lt) |
| PL (1) | PL3394266T3 (lt) |
| SG (1) | SG11201803958WA (lt) |
| SI (1) | SI3394266T1 (lt) |
| WO (1) | WO2017109087A1 (lt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| WO2015105955A1 (en) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| US10174302B1 (en) | 2017-06-21 | 2019-01-08 | Xl-Protein Gmbh | Modified L-asparaginase |
| US11548931B2 (en) | 2017-11-16 | 2023-01-10 | Xl-Protein Gmbh | PASylated VEGFR/PDGFR fusion proteins and their use in therapy |
| CN111406071B (zh) * | 2017-11-16 | 2024-01-16 | 成都硕德药业有限公司 | Pas化的vegfr/pdgfr融合蛋白及其在治疗中的用途 |
| KR102439221B1 (ko) | 2017-12-14 | 2022-09-01 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| US12016889B2 (en) | 2018-02-23 | 2024-06-25 | 9 Meters Biopharma, Inc. | Compositions and methods for treating or preventing intestinal paracellular permeability |
| CN110038120B (zh) * | 2019-04-02 | 2022-12-23 | 河南师范大学 | 豹蛙抗瘤酶融合蛋白作为治疗肿瘤药物的应用 |
| KR102209198B1 (ko) * | 2019-04-02 | 2021-02-02 | 주식회사 바이오앱 | 식물에서의 발현이 최적화된 재조합 이리신 유전자 및 이를 이용한 재조합 이리신 단백질의 생산 방법 |
| US12431219B2 (en) | 2019-04-15 | 2025-09-30 | Bruker Daltonics GmbH & Co. KG | Methods for determining isomeric amino acid residues of proteins and peptides |
| WO2020227341A1 (en) | 2019-05-06 | 2020-11-12 | 9 Meters Biopharma, Inc. | Compositions and methods for treating sjogren's syndrome |
| CA3156066A1 (en) | 2019-10-25 | 2021-04-29 | Mi Rim Choi | Recombinant l-asparaginase |
| KR20230124637A (ko) | 2020-12-22 | 2023-08-25 | 엑스엘-프로테인 게엠베하 | 구조적으로 무질서한 서열에 대해 특이적인 항체 |
| WO2022211829A1 (en) | 2021-03-30 | 2022-10-06 | Jazz Pharmaceuticals Ireland Ltd. | Dosing of recombinant l-asparaginase |
| CA3218973A1 (en) * | 2021-05-14 | 2022-11-17 | Antlia Bioscience, Inc. | Modified b-type natriuretic peptide |
| CN113340864B (zh) * | 2021-06-07 | 2023-04-07 | 郑州轻工业大学 | 基于mef效应二次放大ins信号的适体传感器及其制备方法和应用 |
| CN114470170B (zh) * | 2022-02-22 | 2023-09-19 | 广州新济药业科技有限公司 | 一种司美格鲁肽可溶性微针组合物及其制备方法 |
| WO2024042236A1 (en) | 2022-08-26 | 2024-02-29 | Ethris Gmbh | Stable lipid or lipidoid nanoparticle suspensions |
| GB202218084D0 (en) | 2022-12-01 | 2023-01-18 | Volution Immuno Pharmaceuticals Sa | Fusion proteins |
| WO2024124142A2 (en) * | 2022-12-08 | 2024-06-13 | Insmed Incorporated | Uricase conjugates and methods of use thereof |
| CN115851667B (zh) * | 2023-01-17 | 2026-01-30 | 陕西科技大学 | 一种调控重组核酸酶活性的方法 |
| CN121729225A (zh) | 2023-08-25 | 2026-03-24 | 埃泽瑞斯公司 | 具有增强药物应用的特定表面活性剂性质的稳定脂质和类脂质纳米颗粒制剂 |
| WO2025088193A1 (en) | 2023-10-27 | 2025-05-01 | Xl-Protein Gmbh | Methods for efficient recombinant production of polypeptides |
| WO2025088192A1 (en) | 2023-10-27 | 2025-05-01 | Xl-Protein Gmbh | Methods for the coupling of di(alkyl)amines to polypeptides |
| WO2025233381A1 (en) | 2024-05-07 | 2025-11-13 | Technische Universität München, in Vertretung des Freistaates Bayern | Enzymes that eliminate pyrimidine and/or purine nucleosides for treating cancer |
| CN118979069B (zh) * | 2024-07-31 | 2025-03-18 | 广东省农业科学院植物保护研究所 | Chorion protein 36蛋白在调控雌性瓜实蝇生殖中的应用 |
| CN119162200B (zh) * | 2024-11-04 | 2025-11-11 | 福建农林大学 | 一种水稻新鲜种子抗穗发芽OsRDR3基因及其InDel标记与应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| JP3626187B2 (ja) | 1993-06-07 | 2005-03-02 | バイカル インコーポレイテッド | 遺伝子治療に適するプラスミド |
| CA2225460A1 (en) | 1995-06-23 | 1997-01-09 | Winston Campbell Patterson | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| US7378506B2 (en) | 1997-07-21 | 2008-05-27 | Ohio University | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| US20060252120A1 (en) | 2003-05-09 | 2006-11-09 | Kieliszewski Marcia J | Synthetic genes for plant gums and other hydroxyproline-rich glycoproteins |
| EP2021489A2 (en) | 2006-05-30 | 2009-02-11 | Dow Global Technologies Inc. | Codon optimization method |
| SI2173890T1 (sl) | 2007-06-21 | 2011-06-30 | Univ Muenchen Tech | Biološko aktivni proteini, ki imajo povečano in vivo in/ali in vitro stabilnost |
| US9221882B2 (en) * | 2010-05-21 | 2015-12-29 | Technische Universitat Munchen | Biosynthetic proline/alanine random coil polypeptides and their uses |
| WO2015132004A1 (en) | 2014-03-05 | 2015-09-11 | Merz Pharma Gmbh & Co. Kgaa | Novel recombinant clostridial neurotoxins with increased duration of effect |
| SG11201912625QA (en) | 2017-06-21 | 2020-01-30 | Jazz Pharmaceuticals Ireland Ltd | Modified l-asparaginase |
| CN110891612A (zh) | 2017-06-21 | 2020-03-17 | Xl-蛋白有限责任公司 | 蛋白质药物与p/a肽的缀合物 |
| EP3418383A1 (en) | 2017-06-21 | 2018-12-26 | XL-protein GmbH | Modified l-asparaginase |
| US10174302B1 (en) | 2017-06-21 | 2019-01-08 | Xl-Protein Gmbh | Modified L-asparaginase |
| US11548931B2 (en) | 2017-11-16 | 2023-01-10 | Xl-Protein Gmbh | PASylated VEGFR/PDGFR fusion proteins and their use in therapy |
-
2016
- 2016-12-22 WO PCT/EP2016/082407 patent/WO2017109087A1/en not_active Ceased
- 2016-12-22 CA CA3005115A patent/CA3005115A1/en active Pending
- 2016-12-22 PL PL16828736T patent/PL3394266T3/pl unknown
- 2016-12-22 EP EP21166789.4A patent/EP3919623A1/en not_active Withdrawn
- 2016-12-22 ES ES16828736T patent/ES2877539T3/es active Active
- 2016-12-22 LT LTEP16828736.5T patent/LT3394266T/lt unknown
- 2016-12-22 BR BR112018012784-1A patent/BR112018012784A2/pt active Search and Examination
- 2016-12-22 AU AU2016378646A patent/AU2016378646B2/en active Active
- 2016-12-22 KR KR1020187020867A patent/KR102654180B1/ko active Active
- 2016-12-22 DK DK16828736.5T patent/DK3394266T3/da active
- 2016-12-22 EA EA201891127A patent/EA201891127A1/ru unknown
- 2016-12-22 US US16/064,951 patent/US11401305B2/en active Active
- 2016-12-22 SG SG11201803958WA patent/SG11201803958WA/en unknown
- 2016-12-22 EP EP16828736.5A patent/EP3394266B1/en active Active
- 2016-12-22 JP JP2018532638A patent/JP7065772B2/ja active Active
- 2016-12-22 HU HUE16828736A patent/HUE055267T2/hu unknown
- 2016-12-22 CN CN201680072372.2A patent/CN109153996B/zh active Active
- 2016-12-22 SI SI201631254T patent/SI3394266T1/sl unknown
- 2016-12-22 MX MX2018007680A patent/MX2018007680A/es unknown
-
2018
- 2018-05-14 IL IL259352A patent/IL259352B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018012784A2 (pt) | 2019-02-05 |
| SI3394266T1 (sl) | 2021-08-31 |
| IL259352B (en) | 2022-02-01 |
| MX2018007680A (es) | 2018-11-14 |
| US20190010192A1 (en) | 2019-01-10 |
| KR20180088484A (ko) | 2018-08-03 |
| JP2019508020A (ja) | 2019-03-28 |
| AU2016378646A1 (en) | 2018-06-14 |
| CA3005115A1 (en) | 2017-06-29 |
| CN109153996A (zh) | 2019-01-04 |
| DK3394266T3 (da) | 2021-06-07 |
| CN109153996B (zh) | 2022-03-25 |
| NZ742902A (en) | 2023-12-22 |
| JP7065772B2 (ja) | 2022-05-12 |
| EP3394266A1 (en) | 2018-10-31 |
| US11401305B2 (en) | 2022-08-02 |
| HUE055267T2 (hu) | 2021-11-29 |
| SG11201803958WA (en) | 2018-07-30 |
| PL3394266T3 (pl) | 2021-12-13 |
| WO2017109087A1 (en) | 2017-06-29 |
| EA201891127A1 (ru) | 2019-01-31 |
| AU2016378646B2 (en) | 2023-03-09 |
| KR102654180B1 (ko) | 2024-04-04 |
| ES2877539T3 (es) | 2021-11-17 |
| EP3394266B1 (en) | 2021-04-14 |
| IL259352A (en) | 2018-07-31 |
| EP3919623A1 (en) | 2021-12-08 |
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