LT3601297T - Junginiai, kurie slopina mcl-1 baltymą - Google Patents
Junginiai, kurie slopina mcl-1 baltymąInfo
- Publication number
- LT3601297T LT3601297T LTEPPCT/US2018/024723T LT18024723T LT3601297T LT 3601297 T LT3601297 T LT 3601297T LT 18024723 T LT18024723 T LT 18024723T LT 3601297 T LT3601297 T LT 3601297T
- Authority
- LT
- Lithuania
- Prior art keywords
- protein
- compounds
- inhibit mcl
- mcl
- inhibit
- Prior art date
Links
- 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 title 1
- 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762479230P | 2017-03-30 | 2017-03-30 | |
| US201762479171P | 2017-03-30 | 2017-03-30 | |
| PCT/US2018/024723 WO2018183418A1 (en) | 2017-03-30 | 2018-03-28 | Compounds that inhibit mcl-1 protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3601297T true LT3601297T (lt) | 2022-12-12 |
Family
ID=61972255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/US2018/024723T LT3601297T (lt) | 2017-03-30 | 2018-03-28 | Junginiai, kurie slopina mcl-1 baltymą |
Country Status (35)
| Country | Link |
|---|---|
| US (5) | US10300075B2 (lt) |
| EP (1) | EP3601297B9 (lt) |
| JP (2) | JP6453507B2 (lt) |
| KR (1) | KR102372322B1 (lt) |
| CN (1) | CN110691784B (lt) |
| AU (2) | AU2018244349B2 (lt) |
| BR (1) | BR112019020459B1 (lt) |
| CA (1) | CA3057882A1 (lt) |
| CL (1) | CL2019002777A1 (lt) |
| CO (1) | CO2019011762A2 (lt) |
| CR (1) | CR20190489A (lt) |
| DK (1) | DK3601297T5 (lt) |
| ES (1) | ES2940641T3 (lt) |
| FI (1) | FI3601297T3 (lt) |
| HR (1) | HRP20221412T2 (lt) |
| HU (1) | HUE060919T2 (lt) |
| IL (1) | IL269603B (lt) |
| JO (1) | JOP20190229B1 (lt) |
| LT (1) | LT3601297T (lt) |
| MX (1) | MX389487B (lt) |
| MY (1) | MY204294A (lt) |
| NZ (1) | NZ757606A (lt) |
| PE (1) | PE20200335A1 (lt) |
| PH (1) | PH12019502245A1 (lt) |
| PL (1) | PL3601297T3 (lt) |
| PT (1) | PT3601297T (lt) |
| RS (1) | RS63892B9 (lt) |
| SA (1) | SA519410222B1 (lt) |
| SG (1) | SG11201908945RA (lt) |
| SI (1) | SI3601297T1 (lt) |
| SM (1) | SMT202300122T1 (lt) |
| TW (1) | TWI685493B (lt) |
| UA (1) | UA124784C2 (lt) |
| UY (1) | UY37656A (lt) |
| WO (1) | WO2018183418A1 (lt) |
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| TWI781136B (zh) | 2017-01-20 | 2022-10-21 | 美商阿克思生物科學有限公司 | 用於治療癌症相關病症之唑嘧啶 |
| JP6453507B2 (ja) | 2017-03-30 | 2019-01-16 | アムジエン・インコーポレーテツド | Ｍｃｌ−１タンパク質を阻害する化合物 |
| SG11201908940UA (en) | 2017-03-30 | 2019-10-30 | Hoffmann La Roche | Isoquinolines as inhibitors of hpk1 |
| AR111307A1 (es) | 2017-03-30 | 2019-06-26 | Takeda Pharmaceuticals Co | Derivados de 1,2-dihidroespiro[ciclohexan-1,3-indol] o 1,2-dihidroespiro[ciclohexan-1,3-pirrolo[3,2-b]piridina] como inhibidores de hexakisfosfato quinasa |
| MA49908A (fr) | 2017-08-18 | 2021-04-28 | Amgen Inc | Composés inhibant la protéine mcl-1 |
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2018
- 2018-03-27 JP JP2018059341A patent/JP6453507B2/ja active Active
- 2018-03-28 PT PT187178116T patent/PT3601297T/pt unknown
- 2018-03-28 SG SG11201908945R patent/SG11201908945RA/en unknown
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2020
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