LT3630724T - Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai - Google Patents

Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai

Info

Publication number: LT3630724T
Authority: LT; Lithuania
Prior art keywords: viral replication; replication inhibitors; indoline derivatives; dengue viral; substituted indoline
Prior art date: 2017-05-22

Application number

LTEP18729051.5T

Other languages

English (en)

Inventor

Bart Kesteleyn

Dorothée BARDIOT

Arnaud Marchand

Erwin Coesemans

Benoīt DE BOECK

Pierre Raboisson

Jean-Franēois BONFANTI

Original Assignee

Janssen Pharmaceuticals, Inc.

Katholieke Universiteit Leuven

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-05-22

Filing date

2018-05-18

Publication date

2021-08-25

2018-05-18 Application filed by Janssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven filed Critical Janssen Pharmaceuticals, Inc.

2021-08-25 Publication of LT3630724T publication Critical patent/LT3630724T/lt

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

LTEP18729051.5T 2017-05-22 2018-05-18 Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai LT3630724T (lt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP17172247		2017-05-22
PCT/EP2018/063029 WO2018215316A1 (en)	2017-05-22	2018-05-18	Substituted indoline derivatives as dengue viral replication inhibitors

Publications (1)

Publication Number	Publication Date
LT3630724T true LT3630724T (lt)	2021-08-25

Family

ID=58745159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
LTEP18729051.5T LT3630724T (lt)	2017-05-22	2018-05-18	Pakeistieji indolino dariniai, kaip dengės viruso replikacijos inhibitoriai

Country Status (29)

Country	Link
US (2)	US11053196B2 (lt)
EP (1)	EP3630724B1 (lt)
JP (1)	JP7179773B2 (lt)
KR (1)	KR102625991B1 (lt)
CN (1)	CN110753682B (lt)
AR (1)	AR111820A1 (lt)
AU (1)	AU2018274101C1 (lt)
BR (1)	BR112019024311A2 (lt)
CA (1)	CA3061026C (lt)
CL (1)	CL2019003309A1 (lt)
CO (1)	CO2019013042A2 (lt)
CR (1)	CR20190531A (lt)
DK (1)	DK3630724T3 (lt)
EA (1)	EA039702B1 (lt)
EC (1)	ECSP19083621A (lt)
ES (1)	ES2884157T3 (lt)
HR (1)	HRP20210724T1 (lt)
HU (1)	HUE054379T2 (lt)
IL (1)	IL270727B2 (lt)
LT (1)	LT3630724T (lt)
MX (1)	MX388870B (lt)
PE (1)	PE20200342A1 (lt)
PH (1)	PH12019502577A1 (lt)
SI (1)	SI3630724T1 (lt)
TW (1)	TWI771420B (lt)
UA (1)	UA125970C2 (lt)
UY (1)	UY37741A (lt)
WO (1)	WO2018215316A1 (lt)
ZA (1)	ZA201907713B (lt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB201116559D0 (en)	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors
JOP20160086B1 (ar)	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar)	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar)	2015-09-16	2022-03-14	Janssen Pharmaceuticals Inc	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
SG11201808138YA (en)	2016-03-31	2018-10-30	Janssen Pharmaceuticals Inc	Substituted indole derivatives as dengue viral replication inhibitors
MA44498A (fr)	2016-03-31	2019-02-06	Janssen Pharmaceuticals Inc	Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
EP3436004B1 (en)	2016-04-01	2024-12-11	Janssen Pharmaceuticals, Inc.	Substituted indole compound derivatives as dengue viral replication inhibitors
JOP20170069B1 (ar)	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar)	2017-03-31	2021-08-17	Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180026A1 (ar)	2017-03-31	2019-01-30	Univ Leuven Kath	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CA3060583C (en)	2017-05-22	2024-06-04	Janssen Pharmaceuticals, Inc.	Substituted indoline derivatives as dengue viral replication inhibitors
EA202190046A1 (ru)	2018-06-19	2021-03-24	Новартис Аг	N-замещенные производные тетрагидротиенопиридина и их применение
ES2942310T3 (es)	2018-12-27	2023-05-31	Servier Lab	Inhibidores aza-heterobicíclicos de MAT2A y métodos de uso para el tratamiento del cáncer
US20240368153A1 (en)	2021-07-02	2024-11-07	Mirati Therapeutics, Inc.	Aminopyridine-based MTA-Cooperative PRMT5 Inhibitors

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19651000A1 (de)	1996-12-01	1998-06-04	Schering Ag	Oxyiminopregnancarbolactone
JP2001520998A (ja)	1997-10-27	2001-11-06	イーライ・リリー・アンド・カンパニー	インドールｓＰＬＡ２阻害剤のモルホリノ−Ｎ−エチルエステルプロドラッグ
US6861504B2 (en)	2001-05-03	2005-03-01	Cbr, Inc.	Compounds and methods for the modulation of CD154
GB0110832D0 (en)	2001-05-03	2001-06-27	Virogen Ltd	Antiviral compounds
JP2005520795A (ja)	2001-12-12	2005-07-14	コンフォーマ・セラピューティクス・コーポレイション	Ｈｓｐ９０阻害活性を有するプリン類似体
GB0215293D0 (en)	2002-07-03	2002-08-14	Rega Foundation	Viral inhibitors
US20060211698A1 (en)	2005-01-14	2006-09-21	Genelabs, Inc.	Bicyclic heteroaryl derivatives for treating viruses
AU2006221080A1 (en)	2005-02-09	2006-09-14	Migenix Inc.	Compositions and methods for treating or preventing flaviviridae infections
AU2009256390A1 (en)	2008-06-03	2009-12-10	Siga Technologies, Inc.	Small molecule inhibitors for the treatment or prevention of dengue virus infection
US8143259B2 (en)	2008-08-19	2012-03-27	Janssen Pharmaceutica, Nv	Cold menthol receptor antagonists
WO2010021378A1 (ja)	2008-08-22	2010-02-25	日本化薬株式会社	色素増感型光電変換素子
TWI453207B (zh)	2008-09-08	2014-09-21	Signal Pharm Llc	胺基三唑并吡啶，其組合物及使用其之治療方法
WO2010091413A1 (en)	2009-02-09	2010-08-12	Enanta Pharmaceuticals, Inc.	Linked dibenzimidazole derivatives
GB0910003D0 (en)	2009-06-11	2009-07-22	Univ Leuven Kath	Novel compounds for the treatment of neurodegenerative diseases
US8993604B2 (en)	2009-06-30	2015-03-31	Siga Technologies, Inc.	Treatment and prevention of dengue virus infections
US7948798B1 (en)	2009-07-22	2011-05-24	Marvell International Ltd.	Mixed multi-level cell and single level cell storage device
KR20120123678A (ko)	2010-01-15	2012-11-09	길리애드 사이언시즈, 인코포레이티드	플라비비리다에 바이러스의 억제제
US20130023532A1 (en)	2010-03-26	2013-01-24	Casillas Linda N	Indazolyl-pyrimidines as kinase inhibitors
JP5716205B2 (ja)	2011-03-29	2015-05-13	学校法人日本大学	グルコシダーゼ活性阻害用組成物及びそのスクリーニング方法
GB201116559D0 (en)	2011-09-26	2011-11-09	Univ Leuven Kath	Novel viral replication inhibitors
GB201305376D0 (en)	2013-03-25	2013-05-08	Univ Leuven Kath	Novel viral replication inhibitors
MX368158B (es)	2013-10-23	2019-09-20	Janssen Sciences Ireland Uc	Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
KR20240017118A (ko)	2014-01-31	2024-02-06	브리스톨-마이어스 스큅 컴퍼니	인자 XIa 억제제로서의 헤테로시클릭 P2' 기를 갖는 마크로사이클
PT3201176T (pt)	2014-10-01	2019-03-04	Janssen Pharmaceuticals Inc	Derivados indol mono- ou dissubstituídos como inibidores da replicação viral do dengue
NO2721243T3 (lt)	2014-10-01	2018-10-20
DK3201177T3 (en)	2014-10-01	2019-03-04	Janssen Pharmaceuticals Inc	MONO OR DISUBSTITUTED INDOLES AS INHIBITORS OF DENGUE VIRUS REPLICATION
PH12017501272B1 (en)	2015-01-16	2023-01-11	Janssen Pharmaceuticals Inc	Indole derivatives as dengue viral replication inhibitors
AR103680A1 (es)	2015-02-23	2017-05-24	Lilly Co Eli	Inhibidores selectivos de bace1
JOP20160086B1 (ar) *	2015-05-08	2021-08-17	2 Katholieke Univ Leuven Ku Leuven Research And Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JO3633B1 (ar)	2015-09-16	2020-08-27	Katholieke Univ Leuven Ku Leuven Research & Development	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20160198B1 (ar)	2015-09-16	2022-03-14	Janssen Pharmaceuticals Inc	مشتقات اندول مستبدلة احاديا او ثنائيا بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
EP3370698B1 (en)	2015-11-03	2022-01-26	Zoetis Services LLC	Sol-gel polymer composites and uses thereof
SG11201808138YA (en)	2016-03-31	2018-10-30	Janssen Pharmaceuticals Inc	Substituted indole derivatives as dengue viral replication inhibitors
MY194647A (en)	2016-03-31	2022-12-09	Takeda Pharmaceuticals Co	Heterocyclic compound
MA44498A (fr)	2016-03-31	2019-02-06	Janssen Pharmaceuticals Inc	Dérivés d'indoline substituée utilisés en tant qu'inhibiteurs de la réplication du virus de la dengue
US10603380B2 (en)	2016-04-01	2020-03-31	Kite Pharma, Inc.	Chimeric antigen and T cell receptors and methods of use
CA3015934A1 (en)	2016-04-01	2017-10-05	Basf Se	Bicyclic compounds
EP3436004B1 (en)	2016-04-01	2024-12-11	Janssen Pharmaceuticals, Inc.	Substituted indole compound derivatives as dengue viral replication inhibitors
KR102608405B1 (ko)	2016-04-01	2023-12-01	카이트 파마 인코포레이티드	키메라 수용체 및 그의 사용 방법
JOP20170069B1 (ar)	2016-04-01	2021-08-17	1 Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
KR102694879B1 (ko)	2016-04-01	2024-08-16	암젠 인크	Flt3에 대한 키메라 수용체 및 이의 사용 방법
BR112018070163A2 (pt)	2016-04-01	2019-01-29	Signal Pharm Llc	compostos de aminopurina substituída, composições e métodos de tratamento
JOP20180026A1 (ar)	2017-03-31	2019-01-30	Univ Leuven Kath	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
JOP20180025B1 (ar)	2017-03-31	2021-08-17	Janssen Pharmaceuticals Inc	مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
CA3060583C (en)	2017-05-22	2024-06-04	Janssen Pharmaceuticals, Inc.	Substituted indoline derivatives as dengue viral replication inhibitors

2018
- 2018-05-18 SI SI201830306T patent/SI3630724T1/sl unknown
- 2018-05-18 CA CA3061026A patent/CA3061026C/en active Active
- 2018-05-18 HU HUE18729051A patent/HUE054379T2/hu unknown
- 2018-05-18 CN CN201880033731.2A patent/CN110753682B/zh active Active
- 2018-05-18 CR CR20190531A patent/CR20190531A/es unknown
- 2018-05-18 MX MX2019013878A patent/MX388870B/es unknown
- 2018-05-18 JP JP2019564452A patent/JP7179773B2/ja active Active
- 2018-05-18 LT LTEP18729051.5T patent/LT3630724T/lt unknown
- 2018-05-18 EA EA201992784A patent/EA039702B1/ru unknown
- 2018-05-18 IL IL270727A patent/IL270727B2/en unknown
- 2018-05-18 ES ES18729051T patent/ES2884157T3/es active Active
- 2018-05-18 UA UAA201912061A patent/UA125970C2/uk unknown
- 2018-05-18 TW TW107116922A patent/TWI771420B/zh not_active IP Right Cessation
- 2018-05-18 AU AU2018274101A patent/AU2018274101C1/en active Active
- 2018-05-18 US US16/614,715 patent/US11053196B2/en active Active
- 2018-05-18 BR BR112019024311-9A patent/BR112019024311A2/pt not_active Application Discontinuation
- 2018-05-18 DK DK18729051.5T patent/DK3630724T3/da active
- 2018-05-18 KR KR1020197037345A patent/KR102625991B1/ko active Active
- 2018-05-18 HR HRP20210724TT patent/HRP20210724T1/hr unknown
- 2018-05-18 PE PE2019002416A patent/PE20200342A1/es unknown
- 2018-05-18 WO PCT/EP2018/063029 patent/WO2018215316A1/en not_active Ceased
- 2018-05-18 EP EP18729051.5A patent/EP3630724B1/en active Active
- 2018-05-22 UY UY0001037741A patent/UY37741A/es unknown
- 2018-05-22 AR ARP180101352A patent/AR111820A1/es not_active Application Discontinuation
2019
- 2019-11-18 PH PH12019502577A patent/PH12019502577A1/en unknown
- 2019-11-18 CL CL2019003309A patent/CL2019003309A1/es unknown
- 2019-11-21 ZA ZA2019/07713A patent/ZA201907713B/en unknown
- 2019-11-22 EC ECSENADI201983621A patent/ECSP19083621A/es unknown
- 2019-11-22 CO CONC2019/0013042A patent/CO2019013042A2/es unknown
2021
- 2021-05-28 US US17/334,432 patent/US11702387B2/en active Active

Also Published As

Publication number	Publication date
PE20200342A1 (es)	2020-02-14
CL2019003309A1 (es)	2020-03-20
ES2884157T3 (es)	2021-12-10
ZA201907713B (en)	2022-03-30
US11053196B2 (en)	2021-07-06
IL270727B (en)	2022-11-01
UA125970C2 (uk)	2022-07-20
CN110753682B (zh)	2023-06-30
TWI771420B (zh)	2022-07-21
EA039702B1 (ru)	2022-03-01
TW201900611A (zh)	2019-01-01
CN110753682A (zh)	2020-02-04
US20200181083A1 (en)	2020-06-11
CO2019013042A2 (es)	2020-01-17
CA3061026A1 (en)	2018-11-29
AR111820A1 (es)	2019-08-21
AU2018274101B2 (en)	2022-04-21
WO2018215316A1 (en)	2018-11-29
PH12019502577A1 (en)	2020-07-20
EP3630724A1 (en)	2020-04-08
HUE054379T2 (hu)	2021-09-28
AU2018274101A1 (en)	2019-11-07
CR20190531A (es)	2020-03-05
AU2018274101C1 (en)	2022-09-15
KR102625991B1 (ko)	2024-01-16
UY37741A (es)	2018-11-30
MX2019013878A (es)	2020-01-20
SI3630724T1 (sl)	2021-08-31
IL270727A (en)	2020-01-30
EP3630724B1 (en)	2021-04-28
IL270727B2 (en)	2023-03-01
DK3630724T3 (da)	2021-07-26
CA3061026C (en)	2024-01-30
JP7179773B2 (ja)	2022-11-29
EA201992784A1 (ru)	2020-04-23
HRP20210724T1 (hr)	2021-10-15
MX388870B (es)	2025-03-20
JP2020520950A (ja)	2020-07-16
ECSP19083621A (es)	2019-11-30
KR20200010355A (ko)	2020-01-30
US20210300868A1 (en)	2021-09-30
BR112019024311A2 (pt)	2020-07-28
US11702387B2 (en)	2023-07-18

Publication	Publication Date	Title
ZA201906395B (en)	2021-05-26	Substituted indoline derivatives as dengue viral replication inhibitors
ZA201907713B (en)	2022-03-30	Substituted indoline derivatives as dengue viral replication inhibitors
IL269657A (en)	2019-11-28	Transduced indulin derivatives as inhibitors of dengue virus replication
ZA201806482B (en)	2021-04-28	Substituted indoline derivatives as dengue viral replication inhibitors
IL270726A (en)	2020-01-30	Transduced indulin derivatives as inhibitors of dengue virus replication
ZA202002435B (en)	2023-03-29	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
IL261943A (en)	2018-10-31	Transformed indulin derivatives as inhibitors of dengue virus replication
IL261947A (en)	2018-10-31	History of converted indole compounds as inhibitors of dengue virus replication
ZA201806473B (en)	2020-05-27	Substituted indole derivatives as dengue viral replication inhibitors
ZA201704783B (en)	2019-01-30	Indole derivatives as dengue viral replication inhibitors
IL258043B (en)	2021-08-31	Mono- or di-converted indoles as inhibitors of dengue virus replication
ZA201801764B (en)	2021-04-28	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
SG11201702463YA (en)	2017-04-27	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
SI3625224T1 (sl)	2021-11-30	N-substituirani indolni derivati
HK40013981A (en)	2020-08-14	Substituted indoline derivatives as dengue viral replication inhibitors
HK1261847A1 (en)	2020-01-03	Substituted indoline derivatives as dengue viral replication inhibitors
HK1260967A1 (en)	2019-12-27	Substituted indoline derivatives as dengue viral replication inhibitors
PT3294738T (pt)	2021-06-30	Derivados mono ou di-substituídos de indol como inibidores da replicação viral da dengue